Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptide lactyltransferase (CoA-dependent) activity

CREBBP EP300

1.39e-052752GO:0120300
GeneOntologyMolecularFunctionhistone H3K27 acetyltransferase activity

CREBBP EP300

1.39e-052752GO:0044017
GeneOntologyMolecularFunctionhistone H3K18 acetyltransferase activity

CREBBP EP300

4.17e-053752GO:0043993
GeneOntologyMolecularFunctionSUMO ligase activity

PIAS4 ZMIZ2 ZMIZ1

5.54e-0520753GO:0061665
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

NCOA3 CREBBP EP300

6.45e-0521753GO:0042975
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

PCF11 NCOA3 CREBBP TBP

1.11e-0466754GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

PCF11 NCOA3 CREBBP TBP

1.11e-0466754GO:0001098
GeneOntologyMolecularFunctionTFIIB-class transcription factor binding

CREBBP TBP

2.07e-046752GO:0001093
GeneOntologyMolecularFunctionSMAD binding

JUN ZMIZ1 CREBBP EP300

3.09e-0486754GO:0046332
GeneOntologyMolecularFunctionSUMO transferase activity

PIAS4 ZMIZ2 ZMIZ1

3.32e-0436753GO:0019789
GeneOntologyMolecularFunctioncAMP response element binding

JUN E4F1

8.97e-0412752GO:0035497
GeneOntologyMolecularFunctionhistone acetyltransferase activity

NCOA3 CREBBP EP300

9.31e-0451753GO:0004402
GeneOntologyMolecularFunctiontranscription coactivator activity

NCOA3 KMT2C ZMIZ2 ZMIZ1 CREBBP EP300

9.72e-04303756GO:0003713
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

NCOA3 CREBBP EP300

1.16e-0355753GO:0061733
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

NCOA3 JUN ZNF628 NFYA POU3F2 E2F4 E4F1 MEIS2

1.18e-03560758GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

NCOA3 JUN ZNF628 NFYA POU3F2 E2F4 E4F1 MEIS2

1.26e-03566758GO:0001216
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

CREBBP EP300

1.42e-0315752GO:0010484
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

NCOA3 CREBBP EP300

1.49e-0360753GO:0034212
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

NCOA3 ZMIZ2 ZMIZ1

1.57e-0361753GO:0030374
GeneOntologyMolecularFunctionprotein antigen binding

EP400 EP300

1.61e-0316752GO:1990405
GeneOntologyMolecularFunctionsnRNP binding

SNRPB SNRPN

1.61e-0316752GO:0070990
GeneOntologyMolecularFunctionchromatin binding

NCOA3 JUN EP400 YBX1 POLG E2F4 CREBBP EP300 HELLS

1.76e-03739759GO:0003682
GeneOntologyMolecularFunctiongeneral transcription initiation factor binding

JUN CREBBP TBP

1.80e-0364753GO:0140296
GeneOntologyMolecularFunctiontranscription coregulator binding

ZNF618 NFYA CREBBP EP300

1.91e-03140754GO:0001221
GeneOntologyMolecularFunctiontranscription factor binding

NCOA3 JUN ZNF618 NFYA E4F1 CREBBP EP300 MEIS2 TBP

2.00e-03753759GO:0008134
GeneOntologyMolecularFunctionp53 binding

YBX1 CREBBP EP300

3.05e-0377753GO:0002039
GeneOntologyMolecularFunctionN-acetyltransferase activity

NCOA3 CREBBP EP300

3.16e-0378753GO:0008080
GeneOntologyMolecularFunctionHMG box domain binding

JUN POU3F2

3.35e-0323752GO:0071837
GeneOntologyMolecularFunctionglutamate receptor activity

GRIN2C GRM7

4.60e-0327752GO:0008066
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor binding

CREBBP TBP

4.60e-0327752GO:0001091
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

NCOA3 JUN E4F1 CREBBP EP300 TBP

4.79e-03417756GO:0061629
GeneOntologyMolecularFunctiontranscription coregulator activity

PIAS4 NCOA3 KMT2C ZMIZ2 ZMIZ1 CREBBP EP300

5.13e-03562757GO:0003712
GeneOntologyBiologicalProcesspeptidyl-lysine modification

PIAS4 DIP2B ZMIZ2 ZMIZ1 CREBBP EP300

2.55e-05162746GO:0018205
GeneOntologyBiologicalProcessGolgi ribbon formation

GORASP1 MYO18A FHDC1

7.46e-0523743GO:0090161
GeneOntologyBiologicalProcessN-terminal peptidyl-lysine acetylation

CREBBP EP300

7.58e-054742GO:0018076
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

NCOA3 KMT2C JUN YBX1 ZMIZ2 NFYA POU3F2 E2F4 E4F1 ZMIZ1 CREBBP EP300 MEIS2 CDON TBP

1.04e-0413907415GO:0045944
GeneOntologyCellularComponentchromatin

PIAS4 NCOA3 JUN EP400 ZNF618 ZMIZ2 NFYA POU3F2 E2F4 ZMIZ1 CREBBP EP300 MEIS2 TBP HELLS

1.80e-0414807415GO:0000785
GeneOntologyCellularComponenthistone pre-mRNA 3'end processing complex

YBX1 SNRPB

1.84e-046742GO:0071204
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

NCOA3 JUN NFYA E2F4 CREBBP TBP

4.06e-04272746GO:0090575
GeneOntologyCellularComponentU4/U6 x U5 tri-snRNP complex

SNRPB LSM5 SNRPN

6.17e-0447743GO:0046540
GeneOntologyCellularComponentspliceosomal tri-snRNP complex

SNRPB LSM5 SNRPN

6.57e-0448743GO:0097526
GeneOntologyCellularComponentU4 snRNP

SNRPB SNRPN

9.40e-0413742GO:0005687
GeneOntologyCellularComponentnuclear protein-containing complex

PCF11 NCOA3 KMT2C JUN EP400 YBX1 NFYA E2F4 SNRPB LSM5 CREBBP SNRPN TBP

1.00e-0313777413GO:0140513
GeneOntologyCellularComponenttranscription regulator complex

NCOA3 JUN NFYA POU3F2 E2F4 CREBBP EP300 TBP

1.20e-03596748GO:0005667
GeneOntologyCellularComponentU2-type prespliceosome

SNRPB SNRPN

1.82e-0318742GO:0071004
GeneOntologyCellularComponentprespliceosome

SNRPB SNRPN

1.82e-0318742GO:0071010
HumanPhenoPrecocious puberty

KMT2C GRM7 METTL27 CREBBP SNRPN EP300 LETM1 CDON

1.73e-06186258HP:0000826
HumanPhenoEarly onset of sexual maturation

KMT2C GRM7 METTL27 CREBBP SNRPN EP300 LETM1 CDON

1.95e-06189258HP:0100000
HumanPhenoSporadic

CREBBP SNRPN EP300 LETM1 CDON TBP

7.66e-06103256HP:0003745
HumanPhenoPlantar crease between first and second toes

CREBBP EP300

2.31e-052252HP:0008107
HumanPhenoAortic isthmus hypoplasia

CREBBP EP300

2.31e-052252HP:0034227
HumanPhenoHigh axial triradius

CREBBP EP300

2.31e-052252HP:0001042
HumanPhenoNasogastric tube feeding in infancy

GRM7 CREBBP SNRPN EP300

2.67e-0537254HP:0011470
HumanPhenoBroad toe

ZMYM2 ZMIZ1 CREBBP EP300 MEIS2

5.25e-0587255HP:0001837
HumanPhenoLaryngeal cartilage malformation

CREBBP EP300

6.92e-053252HP:0008752
HumanPhenoPhobia

CREBBP EP300

6.92e-053252HP:5200232
HumanPhenoAgoraphobia

CREBBP EP300

6.92e-053252HP:0000756
HumanPhenoHumoral immunodeficiency

CREBBP EP300

6.92e-053252HP:0005363
HumanPhenoProminent nasal septum

CREBBP EP300

6.92e-053252HP:0005322
HumanPhenoRadial deviation of thumb terminal phalanx

CREBBP EP300

6.92e-053252HP:0005895
HumanPhenoShort finger

COL10A1 ZMYM2 ZMIZ1 GRM7 CREBBP EP300 LETM1 MEIS2

1.04e-04325258HP:0009381
HumanPhenoNarrow nasal bridge

CREBBP SNRPN EP300 CDON

1.12e-0453254HP:0000446
HumanPhenoTrichiasis

CREBBP EP300

1.38e-044252HP:0001128
HumanPhenoVisceral hemangioma

CREBBP EP300

1.38e-044252HP:0410266
HumanPhenoTalon cusp

CREBBP EP300

1.38e-044252HP:0011087
HumanPhenoWidened distal phalanges

CREBBP EP300

1.38e-044252HP:0006200
HumanPhenoVascular ring

CREBBP EP300

1.38e-044252HP:0010775
HumanPhenoHepatic hemangioma

CREBBP EP300

1.38e-044252HP:0031207
HumanPhenoAbnormal esophagus physiology

KMT2C POLG ZMYM2 SNRPB GRM7 METTL27 CREBBP EP300 LETM1 MEIS2 MYORG CDON TBP

1.41e-049332513HP:0025270
HumanPhenoCarious teeth

ZMYM2 SNRPB METTL27 CREBBP SNRPN EP300

1.50e-04174256HP:0000670
HumanPhenoCerebral visual impairment

POLG COG5 GRM7 D2HGDH SNRPN CDON

1.76e-04179256HP:0100704
HumanPhenoAplasia/hypoplasia involving bones of the upper limbs

COL10A1 ZMYM2 ZMIZ1 SNRPB GRM7 CREBBP SNRPN EP300 LETM1 MEIS2

2.00e-045722510HP:0006496
HumanPhenoPapillary cystadenoma of the epididymis

CREBBP EP300

2.29e-045252HP:0009715
HumanPhenoSupernumerary cusp

CREBBP EP300

2.29e-045252HP:0033777
HumanPhenoEpididymal neoplasm

CREBBP EP300

2.29e-045252HP:0030421
HumanPhenoAplasia/Hypoplasia of fingers

COL10A1 ZMYM2 ZMIZ1 GRM7 CREBBP EP300 LETM1 MEIS2

2.40e-04366258HP:0006265
HumanPhenoPhonophobia

METTL27 CREBBP EP300

2.52e-0426253HP:0002183
HumanPhenoPerimembranous ventricular septal defect

CREBBP EP300 MEIS2

2.52e-0426253HP:0011682
HumanPhenoAbnormal upper limb bone morphology

COL10A1 SNRPB GRM7 METTL27 CREBBP SNRPN EP300 LETM1 MEIS2

2.98e-04484259HP:0040070
HumanPhenoAbnormal lateral ventricle morphology

COG5 CREBBP D2HGDH SNRPN EP300

3.41e-04129255HP:0030047
HumanPhenoLarge foramen magnum

CREBBP EP300

3.43e-046252HP:0002700
HumanPhenoShort columella

THUMPD1 CREBBP EP300

3.51e-0429253HP:0002000
HumanPhenoMicrocephaly

KMT2C POLG ZMYM2 THUMPD1 COG5 SNRPB GRM7 METTL27 CREBBP SNRPN EP300 LETM1 MEIS2 MYORG CDON

3.83e-0413412515HP:0000252
HumanPhenoPreaxial foot polydactyly

CREBBP EP300 LETM1

3.89e-0430253HP:0001841
HumanPhenoDiagnostic behavioral phenotype

KMT2C POLG ZMYM2 ZMIZ1 COG5 GRM7 METTL27 CREBBP SNRPN EP300 MEIS2

3.90e-047472511HP:0025783
HumanPhenoDecreased head circumference

KMT2C POLG ZMYM2 THUMPD1 COG5 SNRPB GRM7 METTL27 CREBBP SNRPN EP300 LETM1 MEIS2 MYORG CDON

4.29e-0413542515HP:0040195
HumanPhenoAbnormal hallux morphology

ZMIZ1 METTL27 CREBBP EP300 LETM1 MEIS2

4.41e-04212256HP:0001844
HumanPhenoBroad hallux

ZMIZ1 CREBBP EP300 MEIS2

4.56e-0476254HP:0010055
HumanPhenoTethered cord

ZMYM2 CREBBP LETM1

4.72e-0432253HP:0002144
HumanPhenoTube feeding

COG5 GRM7 CREBBP SNRPN EP300 CDON

4.75e-04215256HP:0033454
HumanPhenoDeviated nasal septum

CREBBP EP300

4.78e-047252HP:0004411
HumanPhenoGastroesophageal reflux

KMT2C POLG SNRPB METTL27 CREBBP EP300 LETM1 MEIS2 CDON

4.91e-04517259HP:0002020
HumanPhenoAbnormal conus terminalis morphology

ZMYM2 CREBBP LETM1

5.17e-0433253HP:0031938
HumanPhenoObstructive sleep apnea

ZMYM2 CREBBP SNRPN EP300

5.29e-0479254HP:0002870
HumanPhenoVesicoureteral reflux

KMT2C ZMYM2 ZMIZ1 METTL27 CREBBP EP300

5.51e-04221256HP:0000076
HumanPhenoAspiration

GRM7 CREBBP EP300

5.65e-0434253HP:0002835
HumanPhenoAbnormal esophagus morphology

KMT2C POLG ZMYM2 SNRPB GRM7 METTL27 CREBBP EP300 LETM1 MEIS2 MYORG CDON TBP

6.36e-0410782513HP:0002031
HumanPhenoBroad phalanx

COL10A1 GRM7 CREBBP EP300 MEIS2

6.42e-04148255HP:0006009
HumanPhenoBroad phalanges of the hand

COL10A1 GRM7 CREBBP EP300 MEIS2

6.42e-04148255HP:0009768
HumanPhenoAplasia/hypoplasia involving bones of the hand

COL10A1 ZMYM2 ZMIZ1 GRM7 CREBBP SNRPN EP300 LETM1 MEIS2

6.60e-04538259HP:0005927
HumanPhenoHydrocele testis

ZMYM2 CREBBP EP300

6.70e-0436253HP:0000034
HumanPhenoShort stature

KMT2C COL10A1 ZMYM2 THUMPD1 COG5 SNRPB GRM7 METTL27 CREBBP SNRPN EP300 LETM1 MEIS2 CDON HELLS

6.74e-0414072515HP:0004322
HumanPhenoBrachydactyly (hand)

COL10A1 ZMYM2 ZMIZ1 GRM7 CREBBP EP300 LETM1 MEIS2

7.21e-04430258HP:0100667
HumanPhenoAuditory sensitivity

METTL27 CREBBP EP300

7.27e-0437253HP:0025112
HumanPhenoAccessory spleen

CREBBP EP300 LETM1

7.27e-0437253HP:0001747
HumanPhenoAuditory hypersensitivity

METTL27 CREBBP EP300

7.27e-0437253HP:5200060
HumanPhenoBroad finger

COL10A1 GRM7 CREBBP EP300 MEIS2

7.70e-04154255HP:0001500
HumanPhenoAbnormal forearm bone morphology

COL10A1 METTL27 CREBBP SNRPN EP300 LETM1

7.81e-04236256HP:0040072
HumanPhenoNatal tooth

KMT2C CREBBP EP300

7.87e-0438253HP:0000695
HumanPhenoAbnormal morphology of bones of the upper limbs

COL10A1 GRM7 METTL27 CREBBP SNRPN EP300 LETM1 MEIS2

7.91e-04436258HP:0040065
HumanPhenoDeviation of the hallux

ZMIZ1 METTL27 CREBBP EP300

7.97e-0488254HP:0010051
HumanPhenoAutistic behavior

KMT2C ZMYM2 ZMIZ1 COG5 GRM7 METTL27 CREBBP SNRPN EP300 MEIS2

8.11e-046782510HP:0000729
HumanPhenoPilomatrixoma

CREBBP EP300

8.15e-049252HP:0030434
HumanPhenoCervical cord compression

CREBBP EP300

8.15e-049252HP:0002341
HumanPhenoAbnormal forearm morphology

COL10A1 METTL27 CREBBP SNRPN EP300 LETM1

8.35e-04239256HP:0002973
HumanPhenoBroad long bones

COL10A1 GRM7 CREBBP EP300 MEIS2

8.41e-04157255HP:0005622
HumanPhenoCellular immunodeficiency

CREBBP EP300 HELLS

8.49e-0439253HP:0005374
HumanPhenoAbnormal long bone morphology

COL10A1 ZMIZ1 COG5 SNRPB GRM7 METTL27 CREBBP SNRPN EP300 LETM1 MEIS2

8.96e-048212511HP:0011314
HumanPhenoAbnormal ureter physiology

KMT2C ZMYM2 ZMIZ1 METTL27 CREBBP EP300

9.52e-04245256HP:0025634
HumanPhenoScoliosis

KMT2C COL10A1 POLG ZMYM2 ZMIZ1 SNRPB METTL27 CREBBP SNRPN EP300 LETM1 MEIS2 CDON

9.54e-0411222513HP:0002650
HumanPhenoHip dysplasia

COL10A1 SNRPB CREBBP SNRPN EP300 LETM1

9.93e-04247256HP:0001385
HumanPhenoFrontal hirsutism

CREBBP EP300

1.02e-0310252HP:0011335
HumanPhenoAbnormal ulnar metaphysis morphology

COL10A1 SNRPN

1.02e-0310252HP:0004039
HumanPhenoConvex nasal ridge

CREBBP EP300 LETM1 MEIS2

1.06e-0395254HP:0000444
HumanPhenoBrain imaging abnormality

KMT2C GRM7 CREBBP SNRPN EP300

1.11e-03167255HP:0410263
HumanPhenoAbnormal columella morphology

THUMPD1 ZMIZ1 CREBBP EP300

1.15e-0397254HP:0009929
HumanPhenoAbnormal subclavian artery morphology

CREBBP EP300

1.24e-0311252HP:0031251
HumanPhenoAbnormal spinal cord morphology

POLG ZMYM2 SNRPB METTL27 CREBBP EP300 LETM1

1.25e-03357257HP:0002143
HumanPhenoFunctional abnormality of the bladder

KMT2C POLG ZMYM2 ZMIZ1 COG5 METTL27 CREBBP EP300 TBP

1.30e-03590259HP:0000009
HumanPhenoSupernumerary spleens

CREBBP EP300 LETM1 CDON

1.34e-03101254HP:0009799
HumanPhenoConstipation

POLG ZMIZ1 METTL27 CREBBP SNRPN EP300 CDON TBP

1.34e-03472258HP:0002019
HumanPhenoAdvanced eruption of teeth

KMT2C CREBBP EP300

1.38e-0346253HP:0006288
HumanPhenoSleep abnormality

ZMYM2 GRM7 METTL27 CREBBP SNRPN EP300 LETM1 CDON TBP

1.40e-03596259HP:0002360
HumanPhenoAbnormally increased volition

KMT2C POLG ZMYM2 ZMIZ1 GRM7 METTL27 CREBBP SNRPN EP300 CDON TBP

1.46e-038692511HP:5200263
HumanPhenoBroad phalanx of the toes

GRM7 CREBBP EP300

1.47e-0347253HP:0010174
HumanPhenoAbnormality of dental structure

ZMYM2 SNRPB METTL27 CREBBP SNRPN EP300 LETM1

1.49e-03368257HP:0011061
HumanPhenoAbnormality of the palpebral fissures

KMT2C ZMYM2 THUMPD1 ZMIZ1 SNRPB METTL27 CREBBP SNRPN EP300 LETM1 MEIS2

1.63e-038802511HP:0008050
HumanPhenoAbnormal nasal bridge morphology

ZMYM2 ZMIZ1 COG5 GRM7 METTL27 CREBBP SNRPN EP300 LETM1 MEIS2 CDON HELLS

1.64e-0310292512HP:0000422
HumanPhenoTracheomalacia

KMT2C POLG SNRPB

1.66e-0349253HP:0002779
HumanPhenoAbnormal stomach morphology

KMT2C POLG SNRPB METTL27 CREBBP SNRPN EP300 LETM1 MEIS2 CDON

1.66e-037422510HP:0002577
HumanPhenoEpicanthus

ZMYM2 THUMPD1 ZMIZ1 SNRPB METTL27 CREBBP EP300 LETM1 HELLS

1.73e-03614259HP:0000286
HumanPhenoFacial grimacing

CREBBP EP300

1.75e-0313252HP:0000273
HumanPhenoKeloids

CREBBP EP300

1.75e-0313252HP:0010562
HumanPhenoSmooth philtrum

THUMPD1 ZMIZ1 CREBBP EP300 MEIS2

1.76e-03185255HP:0000319
HumanPhenoProminent nose

COG5 CREBBP SNRPN EP300

1.84e-03110254HP:0000448
HumanPhenoPatent ductus arteriosus

ZMYM2 ZMIZ1 SNRPB METTL27 CREBBP SNRPN EP300

1.85e-03382257HP:0001643
DomainNuc_rcpt_coact

NCOA3 CREBBP EP300

1.28e-066763IPR009110
Domainzf-MIZ

PIAS4 ZMIZ2 ZMIZ1

2.24e-067763PF02891
DomainZF_SP_RING

PIAS4 ZMIZ2 ZMIZ1

2.24e-067763PS51044
DomainZnf_MIZ

PIAS4 ZMIZ2 ZMIZ1

3.57e-068763IPR004181
DomainNuc_rcpt_coact_CREBbp

CREBBP EP300

1.63e-052762IPR014744
DomainHAT_KAT11

CREBBP EP300

1.63e-052762PF08214
DomainKIX

CREBBP EP300

1.63e-052762PS50952
DomainZnF_TAZ

CREBBP EP300

1.63e-052762SM00551
DomainCBP_P300_HAT

CREBBP EP300

1.63e-052762IPR031162
DomainDUF902

CREBBP EP300

1.63e-052762PF06001
Domain-

CREBBP EP300

1.63e-0527621.20.1020.10
DomainRING_CBP-p300

CREBBP EP300

1.63e-052762IPR010303
Domain-

CREBBP EP300

1.63e-0527621.10.1630.10
DomainCreb_binding

CREBBP EP300

1.63e-052762PF09030
DomainsnRNP-assoc_SmB/SmN

SNRPB SNRPN

1.63e-052762IPR017131
Domain-

CREBBP EP300

1.63e-0527621.10.246.20
Domainzf-TAZ

CREBBP EP300

1.63e-052762PF02135
DomainZF_TAZ

CREBBP EP300

1.63e-052762PS50134
DomainHistone_AcTrfase_Rtt109/CBP

CREBBP EP300

1.63e-052762IPR013178
DomainKAT11

CREBBP EP300

1.63e-052762SM01250
DomainZnf_TAZ

CREBBP EP300

1.63e-052762IPR000197
DomainKIX_dom

CREBBP EP300

1.63e-052762IPR003101
DomainKIX

CREBBP EP300

1.63e-052762PF02172
DomainCBP_P300_HAT

CREBBP EP300

1.63e-052762PS51727
DomainSm

SNRPB LSM5 SNRPN

5.99e-0519763SM00651
DomainLSM

SNRPB LSM5 SNRPN

5.99e-0519763PF01423
DomainLSM_dom_euk/arc

SNRPB LSM5 SNRPN

5.99e-0519763IPR001163
DomainLSM_dom

SNRPB LSM5 SNRPN

9.43e-0522763IPR010920
DomainNUT

NUTM2B NUTM2A

1.62e-045762IPR024310
DomainNUT_N

NUTM2B NUTM2A

1.62e-045762IPR024309
DomainNUT

NUTM2B NUTM2A

1.62e-045762PF12881
DomainFH2

FHDC1 FMNL1

1.66e-0315762PS51444
DomainFH2_Formin

FHDC1 FMNL1

1.66e-0315762IPR015425
DomainFH2

FHDC1 FMNL1

1.66e-0315762PF02181
DomainFH2

FHDC1 FMNL1

1.66e-0315762SM00498
DomainZZ

CREBBP EP300

2.40e-0318762PF00569
DomainZF_ZZ_2

CREBBP EP300

2.40e-0318762PS50135
DomainZF_ZZ_1

CREBBP EP300

2.40e-0318762PS01357
DomainZnf_ZZ

CREBBP EP300

2.67e-0319762IPR000433
DomainZnF_ZZ

CREBBP EP300

2.67e-0319762SM00291
DomainTSPN

THBS4 COL16A1

3.91e-0323762SM00210
DomainBromodomain_CS

CREBBP EP300

4.99e-0326762IPR018359
DomainSNF2_N

EP400 HELLS

7.49e-0332762IPR000330
DomainSNF2_N

EP400 HELLS

7.49e-0332762PF00176
PathwayWP_ANDROGEN_RECEPTOR_SIGNALING

PIAS4 NCOA3 JUN ZMIZ1 CREBBP EP300

1.89e-0691586M39700
PathwayPID_RB_1PATHWAY

JUN E2F4 CREBBP EP300 TBP

6.76e-0665585M279
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

PIAS4 JUN E2F4 CREBBP EP300

2.12e-0582585M2
PathwayPID_HNF3A_PATHWAY

NCOA3 JUN CREBBP EP300

3.10e-0544584M285
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

NFYA CREBBP EP300

3.56e-0516583M27940
PathwayWP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS

JUN YBX1 NFYA POU3F2 CREBBP EP300

4.67e-05159586M39373
PathwayPID_AR_TF_PATHWAY

JUN ZMIZ2 CREBBP EP300

6.50e-0553584M151
PathwayBIOCARTA_VDR_PATHWAY

NCOA3 CREBBP EP300

9.63e-0522583MM1370
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

NCOA3 KMT2C JUN CREBBP EP300

1.42e-04122585M29689
PathwayBIOCARTA_CARM_ER_PATHWAY

CREBBP EP300 TBP

1.61e-0426583M2499
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

1.65e-045582MM1575
PathwayREACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES

CREBBP EP300

1.65e-045582M48020
PathwayREACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES

CREBBP EP300

1.65e-045582M48023
PathwayREACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

CREBBP EP300

1.65e-045582M27228
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

2.47e-046582M22062
PathwayBIOCARTA_RARRXR_PATHWAY

NCOA3 TBP

2.47e-046582MM1447
PathwayPID_RETINOIC_ACID_PATHWAY

NCOA3 CREBBP EP300

2.48e-0430583M207
PathwayWP_ESTROGEN_SIGNALING

JUN CREBBP EP300 TBP

2.79e-0477584MM15934
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

3.45e-047582MM1573
PathwayPID_REG_GR_PATHWAY

JUN CREBBP EP300 TBP

3.55e-0482584M115
PathwayREACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

NCOA3 JUN CREBBP EP300 TBP

3.60e-04149585M27888
PathwayKEGG_TGF_BETA_SIGNALING_PATHWAY

THBS4 E2F4 CREBBP EP300

4.26e-0486584M2642
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

YBX1 E2F4 EP300

4.29e-0436583M633
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

4.58e-048582M22058
PathwayREACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES

CREBBP EP300

4.58e-048582M48022
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

CREBBP EP300

4.58e-048582M48024
PathwayREACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

CREBBP EP300

4.58e-048582M46443
PathwayPID_IFNG_PATHWAY

PIAS4 CREBBP EP300

5.86e-0440583M161
PathwayBIOCARTA_PCAF_PATHWAY

JUN CREBBP

5.88e-049582MM1533
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

CREBBP EP300

5.88e-049582M47451
PathwayREACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION

CREBBP EP300

7.33e-0410582M27945
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

PIAS4 CREBBP EP300

7.77e-0444583M27295
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

JUN NFYA CREBBP EP300

7.83e-04101584M39387
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

JUN NFYA CREBBP EP300

7.83e-04101584MM15829
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

8.93e-0411582MM1521
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

CREBBP EP300

8.93e-0411582M48021
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EP300

8.93e-0411582M26924
PathwayREACTOME_SIGNALING_BY_NOTCH3

YBX1 CREBBP EP300

1.06e-0349583M618
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

1.07e-0312582M7968
PathwayREACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

1.07e-0312582M27765
PathwayWP_WNT_SIGNALING_PATHWAY

PIAS4 JUN EP300 TBP

1.08e-03110584MM15977
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

YBX1 E2F4 EP300

1.20e-0351583M665
PathwayBIOCARTA_PCAF_PATHWAY

JUN CREBBP

1.26e-0313582M22007
PathwayBIOCARTA_PPARA_PATHWAY

JUN CREBBP EP300

1.27e-0352583M2404
PathwayWP_TGFBETA_SIGNALING_PATHWAY

JUN CREBBP EP300

1.34e-0353583MM15880
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NCOA3 NFYA CREBBP EP300

1.40e-03118584M27316
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

PIAS4 EP400 ZMYM2 CREBBP EP300 HELLS

1.44e-03301586MM15983
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP EP300

1.47e-0314582M27808
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

JUN CREBBP EP300

1.49e-0355583M39351
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.69e-0315582MM1339
PathwayBIOCARTA_HIF_PATHWAY

JUN EP300

1.69e-0315582M13324
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.69e-0315582M10183
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.69e-0315582MM1439
PathwayWP_RUBINSTEINTAYBI_SYNDROME_1

NCOA3 CREBBP

1.69e-0315582M48323
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

CREBBP EP300

1.69e-0315582M953
PathwayPID_P53_REGULATION_PATHWAY

E4F1 CREBBP EP300

1.82e-0359583M261
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

JUN CREBBP EP300

1.82e-0359583M39886
PathwayWP_SIDS_SUSCEPTIBILITY_PATHWAYS

YBX1 NFYA EP300

1.82e-0359583MM15838
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP EP300

1.92e-0316582M27121
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

1.92e-0316582M1296
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

1.92e-0316582MM1420
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.92e-0316582M8516
PathwayREACTOME_ESR_MEDIATED_SIGNALING

NCOA3 JUN CREBBP EP300 TBP

2.07e-03220585M27794
PathwayBIOCARTA_ETS_PATHWAY

JUN E2F4

2.17e-0317582M14449
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

2.17e-0317582MM1509
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

CREBBP EP300

2.17e-0317582M48025
PathwayBIOCARTA_ETS_PATHWAY

JUN E2F4

2.17e-0317582MM1435
PathwayPID_MYC_REPRESS_PATHWAY

NFYA EP300 TBP

2.20e-0363583M254
PathwayPID_ERA_GENOMIC_PATHWAY

NCOA3 JUN EP300

2.30e-0364583M200
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

KMT2C CREBBP EP300

2.41e-0365583M39682
PathwayPID_P53_DOWNSTREAM_PATHWAY

JUN NFYA CREBBP EP300

2.41e-03137584M145
PathwayREACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS

MYO18A ZMYM2

2.44e-0318582M673
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP EP300

2.44e-0318582M26942
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G2_CELL_CYCLE_ARREST

E2F4 EP300

2.44e-0318582M27633
PathwayPID_HIF1_TFPATHWAY

JUN CREBBP EP300

2.52e-0366583M255
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION

NFYA CREBBP EP300

2.52e-0366583M27938
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

2.72e-0319582M18933
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

MYO18A ZMYM2

2.72e-0319582M41732
PathwayREACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES

CREBBP EP300

2.72e-0319582M46442
PathwayKEGG_RENAL_CELL_CARCINOMA

JUN CREBBP EP300

2.98e-0370583M13266
PathwayKEGG_LONG_TERM_POTENTIATION

GRIN2C CREBBP EP300

2.98e-0370583M3115
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

3.01e-0320582M27881
PathwayWP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX

CREBBP EP300

3.32e-0321582M39593
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

CREBBP EP300

3.32e-0321582M27485
PathwayWP_MECP2_AND_ASSOCIATED_RETT_SYNDROME

YBX1 POU3F2 CDON

3.35e-0373583M39401
PathwayPID_E2F_PATHWAY

E2F4 CREBBP EP300

3.35e-0373583M40
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

3.65e-0322582MM1443
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

3.98e-0323582M2821
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

YBX1 E2F4 EP300 HELLS

4.31e-03161584M27871
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

4.33e-0324582M13404
Pubmed

Human transcription factor protein interaction networks.

PCF11 NCOA3 KMT2C JUN NOL4L EP400 ADRM1 YBX1 ZMIZ2 DGKK NFYA MYO18A ZMYM2 R3HDM2 ZMIZ1 CREBBP EP300 TBP HELLS

2.13e-101429771935140242
Pubmed

Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.

EP400 CREBBP EP300

1.04e-0837739590171
Pubmed

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.

NCOA3 CREBBP EP300

1.04e-08377311823864
Pubmed

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.

NCOA3 CREBBP EP300 TBP

2.98e-08157749267036
Pubmed

Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes.

CREBBP EP300 TBP

4.17e-0847738995708
Pubmed

Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).

NCOA3 CREBBP EP300

4.17e-08477316227615
Pubmed

Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma.

NCOA3 CREBBP EP300

4.17e-08477333589584
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C CREBBP EP300

4.17e-08477328398509
Pubmed

CBP/p300 interact with and function as transcriptional coactivators of BRCA1.

NCOA3 CREBBP EP300

4.17e-08477310655477
Pubmed

Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB.

JUN CREBBP EP300

4.17e-08477312437352
Pubmed

Binding and modulation of p53 by p300/CBP coactivators.

EP400 CREBBP EP300

4.17e-0847739194565
Pubmed

A transcriptional switch mediated by cofactor methylation.

NCOA3 CREBBP EP300

4.17e-08477311701890
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

NCOA3 JUN ZMIZ2 R3HDM2 ZMIZ1 CREBBP EP300

4.93e-0815277738360978
Pubmed

Interaction network of human early embryonic transcription factors.

PIAS4 NCOA3 KMT2C EP400 ZMIZ2 ZMYM2 ZMIZ1 CREBBP EP300

8.65e-0835177938297188
Pubmed

Human p300 protein is a coactivator for the transcription factor MyoD.

CREBBP EP300 TBP

1.04e-0757738621548
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

NCOA3 JUN CREBBP EP300

1.05e-072077411877444
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PCF11 TPP2 NCOA3 KMT2C JUN NOL4L EP400 YBX1 ZMIZ2 ZMYM2 LSM5 CREBBP EP300 HELLS

1.25e-071103771434189442
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PIAS4 KMT2C JUN ZNF628 EP400 ZMIZ2 POLG ARHGAP44 TXNRD3 RIPOR1 METTL27 D2HGDH EP300 MYORG

1.28e-071105771435748872
Pubmed

Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.

NCOA3 CREBBP EP300

2.08e-07677311076796
Pubmed

A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.

PIAS4 ZMIZ2 ZMIZ1

2.08e-07677320159969
Pubmed

Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.

POU3F2 EP300 TBP

2.08e-07677311029584
Pubmed

The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A.

JUN CREBBP EP300

2.08e-07677310327051
Pubmed

Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation.

JUN CREBBP EP300

2.08e-07677310497212
Pubmed

Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III.

EP400 EP300 TBP

2.08e-07677326871568
Pubmed

The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter.

JUN NFYA EP300

3.63e-07777321565167
Pubmed

Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype.

POU3F2 CREBBP TBP

3.63e-07777316858508
Pubmed

Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.

JUN CREBBP TBP

5.80e-07877316055710
Pubmed

Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression.

NCOA3 CREBBP EP300

5.80e-07877317475621
Pubmed

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.

NCOA3 CREBBP EP300

5.80e-07877310490106
Pubmed

The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.

CREBBP EP300 TBP

8.68e-07977314612417
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA3 JUN EP400 ZMYM2 EP300

1.18e-068377528794006
Pubmed

NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.

NFYA EP300 TBP

1.24e-061077315601870
Pubmed

Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein.

NCOA3 CREBBP EP300

1.24e-061077311163245
Pubmed

A human MAP kinase interactome.

KMT2C JUN NFYA MYO18A ZMYM2 COG5 CREBBP EP300 WDR44

1.31e-0648677920936779
Pubmed

Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.

CREBBP EP300 TBP

1.70e-061177310454579
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

NCOA3 KMT2C EP400 ZMYM2 TBP HELLS

2.00e-0616777620362541
Pubmed

Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.

NCOA3 CREBBP EP300

2.26e-061277314645221
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

JUN EP400 NFYA ZMYM2 THUMPD1 E4F1 COG5 CREBBP EP300 TBP HELLS

2.90e-06857771125609649
Pubmed

A functional interaction between the survival motor neuron complex and RNA polymerase II.

SNRPB SNRPN TBP

2.94e-061377311149922
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

PIAS4 NCOA3 JUN NFYA ZMYM2 E2F4 E4F1 CREBBP EP300 MEIS2 TBP

3.61e-06877771120211142
Pubmed

E protein silencing by the leukemogenic AML1-ETO fusion protein.

CREBBP EP300 TBP

3.73e-061477315333839
Pubmed

A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

JUN CREBBP TBP

4.66e-061577310567404
Pubmed

Loss of p300 accelerates MDS-associated leukemogenesis.

CREBBP EP300

4.84e-06277227881875
Pubmed

Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.

CREBBP EP300

4.84e-06277234845315
Pubmed

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

CREBBP EP300

4.84e-06277219729597
Pubmed

Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.

CREBBP EP300

4.84e-06277215860545
Pubmed

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.

CREBBP EP300

4.84e-06277229460469
Pubmed

Quantifying Protection in Disordered Proteins Using Millisecond Hydrogen Exchange-Mass Spectrometry and Peptic Reference Peptides.

NCOA3 CREBBP

4.84e-06277228675294
Pubmed

Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.

CREBBP EP300

4.84e-06277224551300
Pubmed

Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor.

NFYA TBP

4.84e-06277221705419
Pubmed

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

CREBBP EP300

4.84e-06277233911074
Pubmed

The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

CREBBP EP300

4.84e-0627729018065
Pubmed

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.

CREBBP EP300

4.84e-06277224648406
Pubmed

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

CREBBP EP300

4.84e-06277230135524
Pubmed

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.

CREBBP EP300

4.84e-06277239287984
Pubmed

Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.

CREBBP EP300

4.84e-06277216596650
Pubmed

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

CREBBP EP300

4.84e-06277229217654
Pubmed

Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.

CREBBP EP300

4.84e-06277220717166
Pubmed

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.

CREBBP EP300

4.84e-06277210049825
Pubmed

CBP/p300 acetyltransferase activity in hematologic malignancies.

CREBBP EP300

4.84e-06277227380996
Pubmed

CREBBP and p300 lysine acetyl transferases in the DNA damage response.

CREBBP EP300

4.84e-06277229170789
Pubmed

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

CREBBP EP300

4.84e-06277225893291
Pubmed

Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.

CREBBP EP300

4.84e-06277211559821
Pubmed

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

CREBBP EP300

4.84e-06277221555743
Pubmed

CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.

CREBBP EP300

4.84e-06277212646247
Pubmed

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

CREBBP EP300

4.84e-06277232576962
Pubmed

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.

CREBBP EP300

4.84e-06277219822209
Pubmed

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

CREBBP EP300

4.84e-06277224522976
Pubmed

Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.

CREBBP EP300

4.84e-06277211867645
Pubmed

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

CREBBP EP300

4.84e-06277221847097
Pubmed

The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein.

SNRPB SNRPN

4.84e-0627728510173
Pubmed

Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.

CREBBP EP300

4.84e-06277211963968
Pubmed

Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer.

GAL3ST2 D2HGDH

4.84e-06277227322736
Pubmed

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

CREBBP EP300

4.84e-06277234813504
Pubmed

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.

CREBBP EP300

4.84e-0627729528808
Pubmed

Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.

CREBBP EP300

4.84e-06277212696060
Pubmed

Rubinstein-Taybi Syndrome

CREBBP EP300

4.84e-06277220301699
Pubmed

CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.

CREBBP EP300

4.84e-06277236109165
Pubmed

Potential biomarker of metformin action.

CREBBP EP300

4.84e-06277224639469
Pubmed

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

CREBBP EP300

4.84e-06277237816914
Pubmed

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.

NCOA3 CREBBP

4.84e-06277221632823
Pubmed

Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.

CREBBP EP300

4.84e-06277212242694
Pubmed

Spatial and temporal expression of Zimp7 and Zimp10 PIAS-like proteins in the developing mouse embryo.

ZMIZ2 ZMIZ1

4.84e-06277218053775
Pubmed

Binding of p300/CBP co-activators by polyoma large T antigen.

CREBBP EP300

4.84e-06277211438528
Pubmed

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.

CREBBP EP300

4.84e-06277210918613
Pubmed

Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects.

POLG PPIF

4.84e-06277217122057
Pubmed

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.

CREBBP EP300

4.84e-06277231182547
Pubmed

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.

CREBBP EP300

4.84e-06277235502657
Pubmed

Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.

CREBBP EP300

4.84e-06277230635043
Pubmed

p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.

CREBBP EP300

4.84e-06277231898871
Pubmed

Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.

CREBBP EP300

4.84e-06277227648933
Pubmed

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.

CREBBP EP300

4.84e-06277230888860
Pubmed

Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity.

NFYA EP300

4.84e-06277218815279
Pubmed

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.

CREBBP EP300

4.84e-06277227881443
Pubmed

Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.

CREBBP EP300

4.84e-06277219272189
Pubmed

Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.

CREBBP EP300

4.84e-06277210610021
Pubmed

Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.

CREBBP EP300

4.84e-06277237314181
Pubmed

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.

CREBBP EP300

4.84e-06277212397173
Pubmed

CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.

CREBBP EP300

4.84e-06277215641773
Pubmed

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.

CREBBP EP300

4.84e-06277232690000
InteractionETS1 interactions

PIAS4 NCOA3 JUN EP400 THUMPD1 ZMIZ1 CREBBP EP300 TBP

5.97e-10121749int:ETS1
InteractionSPIB interactions

JUN E2F4 CREBBP EP300 TBP

8.64e-0920745int:SPIB
InteractionNFYB interactions

YBX1 NFYA POU3F2 CREBBP EP300 TBP

1.39e-0765746int:NFYB
InteractionETV4 interactions

NCOA3 JUN ZMIZ2 ZMIZ1 CREBBP EP300

1.99e-0769746int:ETV4
InteractionCRX interactions

PIAS4 SMAP1 NCOA3 KMT2C EP400 ZMIZ2 ZMIZ1 CREBBP EP300

3.77e-07254749int:CRX
InteractionPOU3F2 interactions

NFYA POU3F2 EP300 TBP

7.76e-0720744int:POU3F2
InteractionGTF2B interactions

NCOA3 JUN POU3F2 LSM5 CREBBP EP300 TBP

8.60e-07141747int:GTF2B
InteractionCTBP1 interactions

JUN NOL4L ADSS2 EP400 ZMYM2 E2F4 CREBBP SNRPN EP300 TBP

2.25e-064067410int:CTBP1
InteractionNFYA interactions

JUN NFYA POU3F2 CREBBP EP300 TBP

2.41e-06105746int:NFYA
InteractionSPI1 interactions

JUN NFYA CREBBP EP300 TBP

4.71e-0667745int:SPI1
InteractionKLF5 interactions

NCOA3 KMT2C JUN EP400 CREBBP EP300 TBP

7.42e-06195747int:KLF5
InteractionHNF4A interactions

PIAS4 NCOA3 KMT2C EP400 ZMYM2 CREBBP EP300 TBP

7.51e-06275748int:HNF4A
InteractionBANP interactions

JUN COL10A1 ZMIZ2 NFYA SNRPB SAPCD1 EP300 PPIF

7.92e-06277748int:BANP
InteractionCEBPA interactions

PCF11 TPP2 NCOA3 KMT2C JUN NOL4L EP400 YBX1 ZMIZ2 NFYA ZMYM2 E2F4 LSM5 CREBBP EP300 HELLS

9.12e-0612457416int:CEBPA
InteractionHDAC1 interactions

PIAS4 JUN EP400 ADRM1 ZMIZ2 NFYA ZMYM2 E2F4 E4F1 ZMIZ1 CREBBP EP300 TMEM33 TBP HELLS

9.87e-0611087415int:HDAC1
InteractionSMAD2 interactions

PIAS4 NCOA3 KMT2C JUN RHOD ZMYM2 E2F4 CREBBP EP300

1.14e-05385749int:SMAD2
InteractionSOX7 interactions

NCOA3 KMT2C ZMIZ2 CREBBP EP300

1.27e-0582745int:SOX7
InteractionAR interactions

PCF11 PIAS4 NCOA3 KMT2C JUN EP400 ZMIZ2 MYO18A ZMYM2 E2F4 ZMIZ1 CREBBP EP300 TBP

1.29e-059927414int:AR
InteractionSP7 interactions

PCF11 NCOA3 KMT2C EP400 ZMIZ2 ZMIZ1 CREBBP EP300

1.55e-05304748int:SP7
InteractionPPP1R13L interactions

JUN E2F4 CREBBP D2HGDH EP300

1.80e-0588745int:PPP1R13L
InteractionTOP3B interactions

PIAS4 KMT2C JUN ZNF628 EP400 YBX1 ZMIZ2 POLG ARHGAP44 TXNRD3 RIPOR1 R3HDM2 SNRPB METTL27 D2HGDH EP300 MYORG

1.81e-0514707417int:TOP3B
InteractionFOS interactions

NCOA3 KMT2C JUN EP400 MYO18A CREBBP EP300 TBP

1.87e-05312748int:FOS
InteractionSMAD4 interactions

PIAS4 NCOA3 JUN RHOD MYO18A ZMYM2 E2F4 ZMIZ1 CREBBP EP300

2.31e-055307410int:SMAD4
InteractionPIAS3 interactions

ZMIZ2 ZMIZ1 CREBBP EP300 TBP

2.61e-0595745int:PIAS3
InteractionSOX9 interactions

NCOA3 KMT2C EP400 CREBBP EP300

2.88e-0597745int:SOX9
InteractionEYA4 interactions

NCOA3 JUN ZMIZ2 R3HDM2 ZMIZ1 CREBBP EP300

3.08e-05243747int:EYA4
InteractionFMNL3 interactions

JUN MYO18A FHDC1 FMNL1

3.13e-0549744int:FMNL3
InteractionSMAD3 interactions

PIAS4 NCOA3 JUN YBX1 ZMYM2 E2F4 ZMIZ1 CREBBP EP300

3.70e-05447749int:SMAD3
InteractionEGR2 interactions

NCOA3 KMT2C EP400 ZMIZ2 CREBBP EP300

3.93e-05171746int:EGR2
InteractionTBP interactions

NCOA3 JUN NFYA POU3F2 CREBBP EP300 TBP

3.98e-05253747int:TBP
InteractionPIAS1 interactions

PIAS4 NCOA3 JUN ZMIZ2 ZMYM2 CREBBP EP300 TBP

4.51e-05353748int:PIAS1
InteractionELF3 interactions

JUN CREBBP EP300 TBP

4.61e-0554744int:ELF3
InteractionCIITA interactions

EP400 CREBBP EP300 TBP

4.96e-0555744int:CIITA
InteractionBCL3 interactions

JUN CREBBP EP300 TBP

5.32e-0556744int:BCL3
InteractionJUN interactions

ANKRD35 NCOA3 KMT2C JUN NFYA SNRPB CREBBP EP300 TBP

5.45e-05470749int:JUN
InteractionPAX6 interactions

NCOA3 KMT2C EP400 ZMYM2 CREBBP EP300 MEIS2 TBP

5.82e-05366748int:PAX6
InteractionZBTB7B interactions

DIP2B JUN ZNF628 ADRM1 YBX1 POLG EP300 TBP

5.82e-05366748int:ZBTB7B
InteractionETS2 interactions

NCOA3 JUN CREBBP EP300

7.46e-0561744int:ETS2
InteractionMYOD1 interactions

NCOA3 KMT2C JUN EP400 CREBBP EP300

7.92e-05194746int:MYOD1
InteractionCEBPD interactions

PIAS4 NCOA3 CREBBP EP300

7.95e-0562744int:CEBPD
InteractionCITED2 interactions

CREBBP EP300 TBP

7.98e-0523743int:CITED2
InteractionSUMO1 interactions

PIAS4 NCOA3 JUN ZMYM2 CREBBP D2HGDH EP300

8.80e-05287747int:SUMO1
InteractionHCFC1 interactions

KMT2C JUN EP400 YBX1 E2F4 SNRPB SNRPN

1.00e-04293747int:HCFC1
InteractionVDR interactions

TPP2 NCOA3 JUN CREBBP EP300

1.04e-04127745int:VDR
InteractionGCM1 interactions

NCOA3 KMT2C CREBBP EP300

1.14e-0468744int:GCM1
InteractionTDG interactions

JUN NFYA CREBBP EP300

1.21e-0469744int:TDG
InteractionEGR1 interactions

JUN CREBBP EP300 TBP

1.43e-0472744int:EGR1
InteractionPLRG1 interactions

PCF11 JUN YBX1 E2F4 SNRPB EP300

1.43e-04216746int:PLRG1
InteractionCWF19L1 interactions

E2F4 SNRPB FMNL1 EP300

1.59e-0474744int:CWF19L1
InteractionNUP35 interactions

PCF11 NCOA3 KMT2C THUMPD1 ZMIZ1 CREBBP EP300 TMEM33

1.61e-04424748int:NUP35
InteractionETV1 interactions

NCOA3 JUN EP300

1.62e-0429743int:ETV1
InteractionTGS1 interactions

SNRPB CREBBP SNRPN EP300

1.67e-0475744int:TGS1
InteractionGPBP1 interactions

TSC22D2 CREBBP EP300 TBP

1.67e-0475744int:GPBP1
InteractionWDR5 interactions

KMT2C ADRM1 YBX1 MYO18A ZMYM2 E2F4 SNRPB LSM5 CREBBP EP300 MEIS2 TBP HELLS

1.68e-0411017413int:WDR5
InteractionERG interactions

NCOA3 KMT2C JUN ZMYM2 CREBBP EP300

1.70e-04223746int:ERG
InteractionNCOA6 interactions

KMT2C JUN CREBBP EP300 TBP

1.94e-04145745int:NCOA6
InteractionNCOA1 interactions

NCOA3 JUN CREBBP EP300 TBP

2.01e-04146745int:NCOA1
InteractionHNF1A interactions

NCOA3 KMT2C CREBBP EP300

2.14e-0480744int:HNF1A
InteractionANKRD35 interactions

ANKRD35 JUN YBX1

2.18e-0432743int:ANKRD35
InteractionIRF1 interactions

YBX1 CREBBP EP300 TBP

2.47e-0483744int:IRF1
InteractionSP3 interactions

SNRPB CREBBP EP300 TBP

2.59e-0484744int:SP3
InteractionHOXA9 interactions

JUN CREBBP MEIS2

2.62e-0434743int:HOXA9
InteractionIRF4 interactions

NCOA3 KMT2C ZMIZ2 EP300

2.71e-0485744int:IRF4
InteractionCTNNB1 interactions

ANKRD35 JUN RHOD EP400 YBX1 ZMIZ2 NFYA ZMIZ1 SAPCD1 CREBBP EP300 CDON

2.89e-0410097412int:CTNNB1
InteractionGSC interactions

NCOA3 KMT2C CREBBP EP300

2.96e-0487744int:GSC
InteractionSTAT6 interactions

NCOA3 JUN CREBBP EP300

2.96e-0487744int:STAT6
InteractionE2F5 interactions

E2F4 CREBBP EP300

3.11e-0436743int:E2F5
InteractionHOXB2 interactions

ZMIZ2 CREBBP EP300

3.11e-0436743int:HOXB2
InteractionMAPK14 interactions

NCOA3 KMT2C JUN ADSS2 SNRPB SNRPN EP300

3.13e-04353747int:MAPK14
InteractionSOX10 interactions

NCOA3 JUN POU3F2 EP300

3.67e-0492744int:SOX10
InteractionFOXI1 interactions

NCOA3 KMT2C CREBBP EP300

3.67e-0492744int:FOXI1
InteractionPHOX2A interactions

JUN CREBBP

3.67e-048742int:PHOX2A
InteractionPHAX interactions

PCF11 YBX1 NFYA SNRPB EP300

3.74e-04167745int:PHAX
InteractionNANOG interactions

TPP2 KMT2C EP400 ZMYM2 ZMIZ1 SNRPB EP300 HELLS

3.77e-04481748int:NANOG
InteractionSERTAD2 interactions

CREBBP EP300 HELLS

3.95e-0439743int:SERTAD2
InteractionLSM6 interactions

E2F4 SNRPB LSM5 SNRPN

3.98e-0494744int:LSM6
InteractionNCOR2 interactions

NCOA3 JUN ZSCAN5A E2F4 CREBBP EP300

4.20e-04264746int:NCOR2
InteractionTFF1 interactions

NCOA3 CREBBP EP300

4.58e-0441743int:TFF1
InteractionTLX1 interactions

NCOA3 KMT2C CREBBP EP300 MEIS2

4.63e-04175745int:TLX1
InteractionATF4 interactions

JUN CREBBP EP300 TBP

4.66e-0498744int:ATF4
InteractionSS18L1 interactions

ZMIZ2 SNRPB CREBBP EP300

4.66e-0498744int:SS18L1
InteractionHOXB3 interactions

CREBBP EP300

4.71e-049742int:HOXB3
InteractionARGFX interactions

CREBBP EP300

4.71e-049742int:ARGFX
InteractionTEAD1 interactions

KMT2C JUN CREBBP EP300 TBP

4.75e-04176745int:TEAD1
InteractionNFYC interactions

SMAP1 EP400 NFYA POU3F2 TBP

4.88e-04177745int:NFYC
InteractionBRF2 interactions

SMAP1 TMEM33 TBP

4.92e-0442743int:BRF2
InteractionNPAS2 interactions

NCOA3 CREBBP EP300

4.92e-0442743int:NPAS2
InteractionJDP2 interactions

JUN CREBBP EP300

4.92e-0442743int:JDP2
InteractionPRKRIP1 interactions

YBX1 SNRPB SNRPN

5.28e-0443743int:PRKRIP1
InteractionRARB interactions

NCOA3 EP300 TBP

6.44e-0446743int:RARB
InteractionHNF1B interactions

NCOA3 KMT2C EP400 CREBBP EP300

6.72e-04190745int:HNF1B
InteractionKLF15 interactions

NCOA3 KMT2C NOL4L EP400 CREBBP EP300

6.88e-04290746int:KLF15
InteractionEN1 interactions

KMT2C JUN EP400 EP300

7.21e-04110744int:EN1
InteractionPAX8 interactions

NCOA3 KMT2C CREBBP EP300

7.46e-04111744int:PAX8
InteractionFOSB interactions

JUN CREBBP EP300

7.76e-0449743int:FOSB
InteractionAKAP7 interactions

SNRPB LSM5 SNRPN

7.76e-0449743int:AKAP7
InteractionTBR1 interactions

NCOA3 KMT2C ZMIZ1 EP300

7.97e-04113744int:TBR1
InteractionTFAP2A interactions

JUN YBX1 MYO18A EP300

8.24e-04114744int:TFAP2A
InteractionGATA2 interactions

NCOA3 KMT2C JUN CREBBP EP300

8.28e-04199745int:GATA2
InteractionE2F1 interactions

NCOA3 E2F4 CREBBP EP300 TBP

8.47e-04200745int:E2F1
Cytoband10q22.3

NUTM2E NUTM2B ZMIZ1

5.33e-054377310q22.3
CytobandEnsembl 112 genes in cytogenetic band chr10q22

NUTM2E NUTM2B ZMIZ1 PPIF

4.28e-04208774chr10q22
GeneFamilyZinc fingers MIZ-type

PIAS4 ZMIZ2 ZMIZ1

5.01e-07745385
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA3 CREBBP EP300

9.56e-0617453486
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

9.04e-041845291
GeneFamilyAtaxins|Trinucleotide repeat containing

NCOA3 EP400

1.75e-0325452775
GeneFamilyCollagens

COL10A1 COL16A1

5.85e-0346452490
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000

NCOA3 TENM4 ZNF618 ZMIZ1 CREBBP MEIS2 HELLS

3.63e-05259757gudmap_developingGonad_e12.5_epididymis_k3_1000
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_1000

NCOA3 TENM4 ZNF618 CREBBP MEIS2 CDON HELLS

5.55e-05277757gudmap_developingGonad_e12.5_ovary_k3_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_500

NCOA3 COL16A1 ZMIZ1 GRM7 CREBBP MEIS2 CDON HELLS

9.19e-05406758gudmap_developingGonad_e16.5_epididymis_500
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

NCOA3 KMT2C COL16A1 TENM4 ZNF618 ZMIZ1 GRM7 CREBBP MEIS2 CDON HELLS

9.84e-057907511gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500

NCOA3 TENM4 ZMIZ1 GRM7 CREBBP MEIS2 CDON HELLS

1.03e-04413758gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000

NCOA3 KMT2C COL16A1 TENM4 ZNF618 ZMIZ1 GRM7 CREBBP MEIS2 CDON HELLS

1.11e-048017511gudmap_developingGonad_e14.5_ epididymis_1000
DiseaseMenke-Hennekam syndrome

CREBBP EP300

6.37e-062752cv:C5681632
DiseaseRubinstein-Taybi syndrome (implicated_via_orthology)

CREBBP EP300

6.37e-062752DOID:1933 (implicated_via_orthology)
DiseaseRubinstein-Taybi syndrome

CREBBP EP300

6.37e-062752cv:C0035934
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

6.37e-062752C4551859
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

6.37e-062752180849
DiseaseRubinstein-Taybi syndrome due to CREBBP mutations

CREBBP EP300

6.37e-062752cv:C4551859
DiseaseRubinstein-Taybi syndrome (is_implicated_in)

CREBBP EP300

6.37e-062752DOID:1933 (is_implicated_in)
DiseaseRubinstein-Taybi Syndrome

CREBBP EP300

6.37e-062752C0035934
DiseaseEndometrial Stromal Sarcoma

NUTM2B NUTM2A

6.34e-055752C0206630
DiseaseClear cell sarcoma of kidney

NUTM2E NUTM2B

9.50e-056752C0334488
DiseaseCarcinoma, Transitional Cell

KMT2C CREBBP EP300

1.57e-0441753C0007138
Diseasetauopathy (implicated_via_orthology)

SNRPB SNRPN

2.83e-0410752DOID:680 (implicated_via_orthology)
Diseasecancer antigen 125 measurement

GAL3ST2 D2HGDH

2.83e-0410752EFO_0010603
Diseasemyelodysplastic syndrome (implicated_via_orthology)

POLG CREBBP

6.55e-0415752DOID:0050908 (implicated_via_orthology)
Disease2-hydroxyglutarate measurement

GAL3ST2 D2HGDH

7.48e-0416752EFO_0021506
Diseasecigarettes per day measurement

PIAS4 NOL4L ZNF618 ZMIZ2 MYO18A GRM7

8.78e-04438756EFO_0006525
DiseaseLeukemia, Myelocytic, Acute

KMT2C SYNGR1 CREBBP EP300

1.00e-03173754C0023467
Diseasecolorectal adenoma (is_marker_for)

JUN TXNRD3

1.18e-0320752DOID:0050860 (is_marker_for)
Diseaselung adenocarcinoma (is_marker_for)

KMT2C COL10A1 SNRPB

1.34e-0385753DOID:3910 (is_marker_for)
Diseasechronic widespread pain

DIP2B CDON

1.56e-0323752EFO_0010099
DiseaseSchizophrenia

JUN TENM4 ADSS2 SYNGR1 GRIN2C GRM7 TAPBP TBP

1.79e-03883758C0036341
DiseaseSquamous cell carcinoma of esophagus

KMT2C CREBBP EP300

1.85e-0395753C0279626
DiseaseAdenoid Cystic Carcinoma

KMT2C CREBBP EP300

2.14e-03100753C0010606
DiseaseSezary Syndrome

KMT2C CREBBP

2.15e-0327752C0036920
DiseaseTonic Seizures

POLG D2HGDH LETM1

2.26e-03102753C0270844
DiseaseAbsence Seizures

POLG D2HGDH LETM1

2.26e-03102753C4316903
DiseaseMyoclonic Seizures

POLG D2HGDH LETM1

2.39e-03104753C4317123
DiseaseTonic - clonic seizures

POLG D2HGDH LETM1

2.39e-03104753C0494475
Diseasefacial width measurement

POU3F2 SNRPN CDON

2.45e-03105753EFO_0007855
Diseasesmoking status measurement, Cannabis use, schizophrenia

NOL4L POU3F2

2.48e-0329752EFO_0006527, EFO_0007585, MONDO_0005090
Diseaseglutamate measurement

POU3F2 COG5

2.48e-0329752EFO_0010487

Protein segments in the cluster

PeptideGeneStartEntry
QQPGLVTPVAQGMGS

EP300

311

Q09472
ASPMGVNGGVGVQTP

EP300

511

Q09472
APGPVVMQTVSQAGA

EP400

1671

Q96L91
GAAQFAAAMGVPEIP

ASRGL1

121

Q7L266
QGTVTDMAGRPGQPG

COL16A1

731

Q07092
SQAGGQPMGATGVNP

CREBBP

281

Q92793
GGTVAEPVGPAAMNQ

ANKRD35

476

Q8N283
SGPGVVVMQLNVPNG

R3HDM2

701

Q9Y2K5
QGVLVQPGVDQPGMV

QRICH2

491

Q9H0J4
GPASPQADGQNMVEP

OR5H15

261

A6NDH6
GAAAFGELQNQMPGP

PTPRN2

466

Q92932
GNIATAPGFMIGQTP

FHDC1

16

Q9C0D6
MDRGAAAAQGTAPPQ

DGKK

1

Q5KSL6
PAGSGGSEAPAMVEQ

HELLS

6

Q9NRZ9
VEPVGPSTPNMAAGQ

KMT2C

3661

Q8NEZ4
TSAAQPVNGAGMVAP

JUN

131

P05412
PVNGAGMVAPAVASV

JUN

136

P05412
PEGQPMGSFVLDGQQ

MEIS2

361

O14770
QAGKLAPANGMPTGE

LETM1

631

O95202
PANGSGLPQFVVQMG

PLXNB3

1216

Q9ULL4
MIVDTPGFQNPEQGG

MYO18A

786

Q92614
GVGPASVMVGNLVAG

DIP2B

951

Q9P265
QIFGQGGEMPGEAAV

POLG

86

P54098
QGDPAFPEMNGNGAV

NOL4L

61

Q96MY1
MGLGVSAEQPAGGAE

GORASP1

1

Q9BQQ3
GNNITMLVPGGEGPE

LSM5

76

Q9Y4Y9
VDGSPGMLEQAQAPG

METTL27

96

Q8N6F8
GNFGNIPAPMTVGNI

PCF11

1201

O94913
MTAAQAAGEEAPPGV

RHOD

1

O00212
NPAPANMEGGGGSVA

COG5

26

Q9UP83
LFGGQAEGPPVTNIM

GAL3ST2

41

Q9H3Q3
AVPGSAEVQGMAGPA

E2F4

251

Q16254
VNGGGMYTAVPQIDP

CDON

1091

Q4KMG0
MGNAAGSAEQPAGPA

FMNL1

1

O95466
ALGGMGPDTAPQAQV

KLHDC8B

131

Q8IXV7
AGTPVMFNKNGDAPG

GRM7

461

Q14831
DGEMAEAPGSPRQQG

E4F1

156

Q66K89
GNTGMVGGSVPVFDE

D2HGDH

131

Q8N465
PIMVQAVPGGQGQTI

NFYA

76

P23511
AVPGGQGQTIMQVPV

NFYA

81

P23511
AAPVVPVMAAQVVGG

NUTM2A

251

Q8IVF1
AAPVVPVMAAQVVGG

NUTM2B

251

A6NNL0
AAPVVPVMAAQVVGG

NUTM2E

251

B1AL46
VRGVGGPSQQVMTPQ

SNRPN

131

P63162
AMAPRTGPAQGGQVA

TSC22D2

436

O75157
GMGQQPDPAFGRVSS

NCOA3

1316

Q9Y6Q9
VRGVGGPSQQVMTPQ

SNRPB

131

P14678
GPGVLSMANAGPNTN

PPIF

136

P30405
TGLGMPPQNVGEVYG

ADSS2

281

P30520
MGSQGSGGVPLVQAP

SAPCD1

1

Q5SSQ6
ASIVHAEPPGGMQQG

POU3F2

16

P20265
GQPGAMADQSAGQPS

ARHGAP44

661

Q17R89
PPQEGMVPVAQAGSS

SCARF1

541

Q14162
PGVMDGVPSANNYQG

HIBADH

261

P31937
LATMNVPAGPAGGQQ

ADRM1

271

Q16186
PGQAVMPEGFIKAGQ

COL10A1

516

Q03692
DACPVGFTGPMVQGV

THBS4

351

P35443
MNQPGGAAAPQADGA

ZNF618

1

Q5T7W0
PPVQGEVMEGADNQG

YBX1

211

P67809
AQGLASPQGAMTPGI

TBP

11

P20226
TPGLNGQMPAAQEGA

TAPBP

221

O15533
GVDPGAPGMQVTTDG

TPP2

46

P29144
ATPVGNRESPGQAGM

ZSCAN5A

316

Q9BUG6
DGQTVAGEVMGPQRP

WDR44

326

Q5JSH3
VSQQPPVIGSIMGNG

TENM4

1196

Q6N022
DPAGMGGTYQQPANT

SYNGR1

206

O43759
AAPGLIGNVMGQSPS

SMAP1

351

Q8IYB5
MGPAVLGQGQEGQPE

UBE2Q2L

1

H0YL09
GPVGSMENGKPGADV

PIAS4

451

Q8N2W9
ATQSQVLGNPMGPAG

ZMIZ2

51

Q8NF64
VGPFNPGRMNVAGDV

ZMYM2

256

Q9UBW7
GPNAGEVTQGFAAAM

TXNRD3

586

Q86VQ6
MAVQTPVPTAAGGSG

RIPOR1

776

Q6ZS17
MADTTPNGPQGAGAV

TMEM33

1

P57088
MAAPAQQTTQPGGGK

THUMPD1

1

Q9NXG2
GMNAAINTGPAPAVT

TEX38

76

Q6PEX7
GQAGAQGASDMPEPS

ZMIZ1

1016

Q9ULJ6
PGAPASQMVQVVPAG

ZNF628

1016

Q5EBL2
SQMVQVVPAGAGPGV

ZNF628

1021

Q5EBL2
FLPAMIGGQEGQASP

MYO7B

921

Q6PIF6
PDMVGGNAVPQRTAG

MYORG

551

Q6NSJ0
LGPGQGEQGMTVAVV

GRIN2C

21

Q14957