Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	9.02e-05	82	110	5	GO:1990756
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	PIGK SENP6 USP48 CTSK SENP7	1.13e-04	86	110	5	GO:0004197
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	1.81e-04	95	110	5	GO:0140767
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	2.39e-04	55	110	4	GO:0042974
GeneOntologyMolecularFunction	peptidase activity	DPP6 ZC3H12A PIGK RNPEPL1 BACE1 ST14 THOP1 SENP6 KLK13 USP48 CTSK SENP7	2.59e-04	654	110	12	GO:0008233
GeneOntologyMolecularFunction	ankyrin binding	SPTBN1 OBSCN IQCJ-SCHIP1	2.66e-04	23	110	3	GO:0030506
GeneOntologyMolecularFunction	transcription coactivator activity	TRIM15 TRIM31 DYRK1A NCOA4 TRIM22 CNOT9 RNF20 MED12L	2.75e-04	303	110	8	GO:0003713
GeneOntologyMolecularFunction	calmodulin binding	IQCF5 MYO1G MYO1E SPTBN1 OBSCN STRN4 IQCJ-SCHIP1	2.86e-04	230	110	7	GO:0005516
GeneOntologyMolecularFunction	ubiquitin-like protein-specific endopeptidase activity	SENP6 SENP7	2.97e-04	5	110	2	GO:0070137
GeneOntologyMolecularFunction	SUMO-specific endopeptidase activity	SENP6 SENP7	2.97e-04	5	110	2	GO:0070139
GeneOntologyMolecularFunction	phosphatidylinositol binding	MYO1G AMER1 ADAP1 MYO1E PIGK OBSCN ITPR2 FES	3.65e-04	316	110	8	GO:0035091
GeneOntologyMolecularFunction	ATP-dependent activity	MYO1G MYO1E CPOX HELQ KIF7 EIF4A1 ABCB11 DDX60L ATP6V0D2 ATP12A DYNC1H1	5.77e-04	614	110	11	GO:0140657
GeneOntologyMolecularFunction	endopeptidase activity	PIGK BACE1 ST14 THOP1 SENP6 KLK13 USP48 CTSK SENP7	6.25e-04	430	110	9	GO:0004175
GeneOntologyMolecularFunction	cysteine-type peptidase activity	ZC3H12A PIGK SENP6 USP48 CTSK SENP7	6.84e-04	192	110	6	GO:0008234
GeneOntologyMolecularFunction	phospholipid binding	MYO1G AMER1 ADAP1 MYO1E PIGK SPTBN1 OBSCN ITPR2 CPNE3 FES	8.99e-04	548	110	10	GO:0005543
GeneOntologyMolecularFunction	P-type sodium transporter activity	CPOX ATP12A	1.31e-03	10	110	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	CPOX ATP12A	1.31e-03	10	110	2	GO:0005391
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	CPOX ATP12A	1.60e-03	11	110	2	GO:0008556
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	TRIM15 PRAMEF9 PRAMEF15 TRIM31 DYRK1A PRAMEF4 NCOA4 TRIM22 CNOT9 TONSL RNF20 STRN4 MED12L PRAMEF27 PRAMEF11	1.73e-03	1160	110	15	GO:0030674
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	4.13e-06	47	107	5	GO:0031462
GeneOntologyCellularComponent	spectrin	SPTA1 SPTBN1 SPTBN5	1.07e-05	9	107	3	GO:0008091
GeneOntologyCellularComponent	cuticular plate	MYO1E SPTA1 SPTBN1	3.59e-05	13	107	3	GO:0032437
GeneOntologyCellularComponent	protein phosphatase 4 complex	PPP4R3A PPP4R3B	3.84e-04	6	107	2	GO:0030289
GeneOntologyCellularComponent	cortical cytoskeleton	MYO1E SPTA1 SPTBN1 SPTBN5 PDE4DIP	5.32e-04	129	107	5	GO:0030863
Domain	SMK-1	PPP4R3A PPP4R3B	3.19e-05	2	106	2	PF04802
Domain	DUF625	PPP4R3A PPP4R3B	3.19e-05	2	106	2	IPR006887
Domain	PRAME_family	PRAMEF15 PRAMEF4 PRAMEF27	1.61e-04	19	106	3	IPR026271
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTA1 SPTBN1 SPTBN5	1.98e-05	10	79	3	MM15112
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	4.41e-07	20	110	4	26694250
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AARS1 MYO1E SPTBN1 DYRK1A VPS26A JAKMIP3 PPP4R3B THOP1 MTIF2 EIF4A1 SH3D19 PDE4DIP LRP2 SENP6 PLCG1 DYNC1H1 CAP2	6.05e-07	1285	110	17	35914814
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	6.63e-07	22	110	4	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	1.14e-06	25	110	4	37451217
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	1.83e-06	28	110	4	25089626
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	AARS1 LMNB2 SF3B3 PI4KA EIF4A1 RARS2 DYNC1H1	3.27e-06	197	110	7	31620119
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	4.60e-06	35	110	4	19389355
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	AARS1 SPTA1 SPTBN1 EPG5 DUOX1 THOP1 SF3B3 EIF4A1 TONSL RNF20 CPNE3 DYNC1H1	9.89e-06	807	110	12	30575818
Pubmed	Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.	PPP4R3A PPP4R3B	9.91e-06	2	110	2	16107728
Pubmed	Conformational change of erythroid alpha-spectrin at the tetramerization site upon binding beta-spectrin.	SPTA1 SPTBN1	9.91e-06	2	110	2	17905835
Pubmed	High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1.	LRP2 ABCB11	9.91e-06	2	110	2	10556425
Pubmed	Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7.	SENP6 SENP7	9.91e-06	2	110	2	18799455
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NEDD4L SPTBN1 DYRK1A LMNB2 JAKMIP3 KIF7 PI4KA EIF4A1 SH3D19 PDE4DIP STRN4 DYNC1H1 CAP2	1.16e-05	963	110	13	28671696
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DOCK4 UFC1 DYRK1A PPP4R3A DERA PPP4R3B FADS1 SF3B3 EIF4A1 TONSL STRN4 FES RARS2 ELL DYNC1H1	1.31e-05	1284	110	15	17353931
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DOCK4 KRT14 PPP4R3A BRAP PPP4R3B SF3B3 PI4KA TONSL CPNE3 SENP6	1.82e-05	588	110	10	38580884
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF15 PRAMEF4 PRAMEF11	2.03e-05	17	110	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF15 PRAMEF4 PRAMEF11	2.03e-05	17	110	3	37781892
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF15 PRAMEF4 PRAMEF11	2.43e-05	18	110	3	23894331
Pubmed	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.	TRIM15 TRIM31 TRIM22	2.43e-05	18	110	3	23077300
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF15 PRAMEF4 PRAMEF11	2.43e-05	18	110	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF15 PRAMEF4 PRAMEF11	2.43e-05	18	110	3	29731491
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTA1 SPTBN1 SPTBN5	2.43e-05	18	110	3	12119179
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF15 PRAMEF4 PRAMEF11	2.43e-05	18	110	3	14675769
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF15 PRAMEF4 PRAMEF11	2.43e-05	18	110	3	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF15 PRAMEF4 PRAMEF11	2.87e-05	19	110	3	28604677
Pubmed	Neuronal Localization of SENP Proteins with Super Resolution Microscopy.	SENP6 SENP7	2.97e-05	3	110	2	33113832
Pubmed	Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury.	ST14 NPHS2	2.97e-05	3	110	2	32907879
Pubmed	Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation.	KRT14 ST14	2.97e-05	3	110	2	16980306
Pubmed	The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons.	SEMA3A FES	2.97e-05	3	110	2	18053124
Pubmed	p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor.	ADAP1 PLCG1	2.97e-05	3	110	2	16341594
Pubmed	A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.	BRAP PLCG1	2.97e-05	3	110	2	22022282
Pubmed	IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.	IQCJ IQCJ-SCHIP1	2.97e-05	3	110	2	17045569
Pubmed	Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin.	NPHS2 LRP2	2.97e-05	3	110	2	32200668
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF15 PRAMEF4 PRAMEF11	3.37e-05	20	110	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF15 PRAMEF4 PRAMEF11	3.37e-05	20	110	3	21425410
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AMER1 SPTBN1 PRAMEF15 OBSCN DYRK1A PRAMEF4 NCOA4 THOP1 PI4KA CPNE3 LRP2 PLCG1 PRAMEF11	3.96e-05	1084	110	13	11544199
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF15 PRAMEF4 PRAMEF11	5.21e-05	23	110	3	19480014
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	AARS1 APOO PIGK DYRK1A CPOX PPP4R3A SEMA3A THOP1 FADS1 SF3B3 MTIF2 EIF4A1 RNF20 RARS2 USP6NL	5.35e-05	1451	110	15	30550785
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	AARS1 MYO1E EEF1E1 SPTBN1 VPS26A PPP4R3A DERA PPP4R3B THOP1 RNF20 STRN4 PLCG1 USP48 DYNC1H1 CAP2	5.51e-05	1455	110	15	22863883
Pubmed	Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells.	PPP4R3A PPP4R3B	5.92e-05	4	110	2	21423269
Pubmed	Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.	PI4KA PLCG1	5.92e-05	4	110	2	7761838
Pubmed	Abolishment of proximal tubule albumin endocytosis does not affect plasma albumin during nephrotic syndrome in mice.	NPHS2 LRP2	5.92e-05	4	110	2	29032953
Pubmed	IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.	ERN1 ITPR2	5.92e-05	4	110	2	26193638
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTA1 SPTBN1	5.92e-05	4	110	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTA1 SPTBN1	5.92e-05	4	110	2	3862089
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTA1 SPTBN1	5.92e-05	4	110	2	21412925
Pubmed	Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis.	PPP4R3A PPP4R3B	5.92e-05	4	110	2	20876121
Pubmed	Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A.	SPTBN1 SEMA3A	5.92e-05	4	110	2	34812142
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTA1 SPTBN1	5.92e-05	4	110	2	12820899
Pubmed	PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.	DYRK1A PPP4R3A PDE4DIP	5.94e-05	24	110	3	24710276
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	AARS1 KRT14 APOO MYO1E PIGK SF3B3 CPNE3 DYNC1H1	6.13e-05	422	110	8	27342126
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF15 PRAMEF4 PRAMEF11	6.73e-05	25	110	3	12620990
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTA1 SPTBN1 SPTBN5	6.73e-05	25	110	3	8493579
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF15 PRAMEF4 PRAMEF11	7.59e-05	26	110	3	18500982
Pubmed	MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.	MYO1G AARS1 MYO1E HLA-DRB4 SPTBN1 PI4KA EIF4A1 CPNE3 DYNC1H1	8.03e-05	565	110	9	20458337
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	AARS1 UFC1 CPOX KLHL11 PI4KA EIF4A1 A2ML1 CPNE3 DYNC1H1	8.69e-05	571	110	9	37167062
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	MYO1G MYO1E VPS26A CPNE3 DYNC1H1	9.48e-05	143	110	5	30397336
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	MYO1E SPTBN1 OBSCN DMXL1 SF3B3 ABCB11 DYNC1H1	9.48e-05	333	110	7	32665550
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	AARS1 SPTBN1 LMNB2 VPS26A CXXC1 SF3B3 PI4KA EIF4A1 A2ML1 RNF20 CPNE3 DDX60L PLCG1 DYNC1H1	9.58e-05	1353	110	14	29467282
Pubmed	Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.	IQCJ IQCJ-SCHIP1	9.85e-05	5	110	2	18550753
Pubmed	Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.	ATP6V0D2 CTSK	9.85e-05	5	110	2	22806935
Pubmed	Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7.	SENP6 SENP7	9.85e-05	5	110	2	21878624
Pubmed	T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.	SPTA1 SPTBN1	9.85e-05	5	110	2	29720258
Pubmed	Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice.	PLCG1 ADGRE1	9.85e-05	5	110	2	19056831
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF15 PRAMEF4 PRAMEF11	1.17e-04	30	110	3	38786026
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	ITPR2 PI4KA EIF4A1 TONSL DYNC1H1	1.19e-04	150	110	5	30154076
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF15 PRAMEF4 PRAMEF11	1.43e-04	32	110	3	37889087
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR2 PLCG1	1.47e-04	6	110	2	21762810
Pubmed	Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene.	SPTA1 PLCG1	1.47e-04	6	110	2	7517397
Pubmed	UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages.	ERN1 UFC1	1.47e-04	6	110	2	33372156
Pubmed	A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.	DPP6 ITPR2	1.47e-04	6	110	2	19193627
Pubmed	Analysis of erythrocyte and platelet membrane proteins in various forms of beta-thalassemia.	SPTA1 SPTBN1	1.47e-04	6	110	2	15310273
Pubmed	Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.	MYO1G MYO1E	1.47e-04	6	110	2	12486594
Pubmed	Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.	KRT14 ST14	1.47e-04	6	110	2	14638864
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF15 PRAMEF4 THOP1 FAM193A PDE4DIP PRAMEF11 SENP7	1.61e-04	363	110	7	14691545
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	IQCF5 KRT14 AMER1 ADAP1 SPTA1 SPTBN1 LMNB2 CPOX CXXC1 SF3B3 H4C7 EIF4A1 STRN4 ATP12A	1.86e-04	1442	110	14	35575683
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYO1E RNPEPL1 OBSCN DYRK1A LMNB2 ST14 ITPR2 PI4KA STRN4 PLCG1 ELL DYNC1H1	2.01e-04	1105	110	12	35748872
Pubmed	Exportin 7 defines a novel general nuclear export pathway.	VPS26A EIF4A1	2.06e-04	7	110	2	15282546
Pubmed	Parallel mechanisms suppress cochlear bone remodeling to protect hearing.	ATP6V0D2 CTSK	2.06e-04	7	110	2	27085457
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	NEDD4L TRIM31 BRAP RNF20	2.42e-04	95	110	4	29643511
Pubmed	A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.	CNOT9 EIF4A1	2.74e-04	8	110	2	24768540
Pubmed	NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.	ADGRE1 CTSK	2.74e-04	8	110	2	16680826
Pubmed	A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.	PPP4R3A PPP4R3B	2.74e-04	8	110	2	18614045
Pubmed	The semaphorin 3A receptor may directly regulate the activity of small GTPases.	SEMA3A FES	2.74e-04	8	110	2	11108845
Pubmed	The tripartite motif family identifies cell compartments.	TRIM15 TRIM31 TRIM22	3.01e-04	41	110	3	11331580
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	AARS1 KIF7 ITPR2 RNF20 ABCB11 RARS2	3.02e-04	285	110	6	32838362
Pubmed	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	DPP6 PTPRT ITPR2 NPHS2	3.05e-04	101	110	4	18519826
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK4 NEDD4L POGK EPG5 PDE4DIP DYNC1H1 SENP7	3.23e-04	407	110	7	12693553
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	AARS1 SPTBN1 SF3B3 DYNC1H1	3.42e-04	104	110	4	36055981
Pubmed	A lineage of myeloid cells independent of Myb and hematopoietic stem cells.	KRT14 ADGRE1	3.52e-04	9	110	2	22442384
Pubmed	Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesis.	PPP4R3A PPP4R3B	3.52e-04	9	110	2	28467410
Pubmed	Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.	SPTBN1 USP48 ELL	3.97e-04	45	110	3	33596420
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF15 PRAMEF4 PRAMEF11	4.23e-04	46	110	3	17287250
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	KRT14 GLT1D1 SPTBN1 PRAMEF15 OBSCN PRAMEF4 PI4KA PRAMEF11	4.39e-04	564	110	8	21565611
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTA1 SPTBN1	4.39e-04	10	110	2	22159418
Pubmed	A B-Myb complex containing clathrin and filamin is required for mitotic spindle function.	SPTA1 SPTBN1	4.39e-04	10	110	2	18548008
Pubmed	Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.	NPHS2 LRP2	4.39e-04	10	110	2	30046000
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	AARS1 KRT14 MYO1E SPTBN1 LMNB2 DYNC1H1	4.87e-04	312	110	6	37120454
Pubmed	Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.	KRT14 NEDD4L	5.35e-04	11	110	2	21505443
Pubmed	Nucleoplasmic calcium regulates cell proliferation through legumain.	AARS1 SF3B3	5.35e-04	11	110	2	21237226
Cytoband	1p36.21	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11	1.73e-05	63	111	4	1p36.21
Cytoband	3q12	CPOX SENP7	5.77e-05	5	111	2	3q12
Cytoband	Ensembl 112 genes in cytogenetic band chr18q21	NEDD4L GRP CXXC1 EPG5	1.59e-03	205	111	4	chr18q21
Cytoband	2p16.1	PPP4R3B MTIF2	2.74e-03	32	111	2	2p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2p16	SPTBN1 PPP4R3B MTIF2	3.22e-03	121	111	3	chr2p16
GeneFamily	PRAME family	PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11	4.59e-08	24	76	5	686
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTBN1 SPTBN5	2.47e-06	7	76	3	1113
GeneFamily	SUMO specific peptidases	SENP6 SENP7	3.61e-04	7	76	2	984
GeneFamily	Myosins, class I	MYO1G MYO1E	4.80e-04	8	76	2	1097
GeneFamily	Helix-turn-helix CENPB type domain containing	TIGD7 POGK	1.32e-03	13	76	2	533
Drug	tetrathionate	SPTA1 SPTBN1 LMNB2 SPTBN5 FES	3.37e-06	49	107	5	CID000026259
Disease	corpus callosum anterior volume measurement	PPP4R3A SEMA3A IQCJ IQCJ-SCHIP1	1.05e-05	39	103	4	EFO_0010295
Disease	congenital muscular dystrophy (implicated_via_orthology)	LMNB2 DYNC1H1	1.79e-04	6	103	2	DOID:0050557 (implicated_via_orthology)
Disease	triglyceride change measurement, response to long-chain n-3 PUFA dietary supplementation	IQCJ IQCJ-SCHIP1	3.33e-04	8	103	2	EFO_0007681, EFO_0009308
Disease	corpus callosum volume measurement	PPP4R3A SEMA3A IQCJ IQCJ-SCHIP1	4.25e-04	100	103	4	EFO_0010299
Disease	mean corpuscular hemoglobin concentration	RNPEPL1 SPTA1 NCOA4 DMXL1 BRAP ITPR2 FADS1 RNF20 ABCB11 IQCJ-SCHIP1 ELL SENP7	4.77e-04	1105	103	12	EFO_0004528
Disease	left ventricular systolic function measurement	NEDD4L MYO1E OBSCN	4.93e-04	44	103	3	EFO_0008206
Disease	esophagus squamous cell carcinoma (is_implicated_in)	CHRNA5 PTPRT FES	5.27e-04	45	103	3	DOID:3748 (is_implicated_in)
Disease	Cognitive impairment	PTPRT DMXL1	6.50e-04	11	103	2	HP_0100543
Disease	corpus callosum posterior volume measurement	SEMA3A IQCJ IQCJ-SCHIP1	8.06e-04	52	103	3	EFO_0010298
Disease	Familial idiopathic steroid-resistant nephrotic syndrome	MYO1E NPHS2	9.18e-04	13	103	2	cv:C4273714
Disease	pursuit maintenance gain measurement	MYO1G EPG5 DDX60L CAP2	9.25e-04	123	103	4	EFO_0008433
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	MYO1E FADS1	1.07e-03	14	103	2	OBA_2045142
Disease	bone mineral accretion measurement, response to corticosteroid	DPP6 PTPRT	1.07e-03	14	103	2	EFO_0007591, GO_0031960
Disease	lung small cell carcinoma (is_marker_for)	GRP CHRNA5	1.40e-03	16	103	2	DOID:5409 (is_marker_for)
Disease	Charcot-Marie-Tooth disease type 2	AARS1 DYNC1H1	1.59e-03	17	103	2	cv:C0270914
Disease	Microcephaly	UFC1 DYRK1A DYNC1H1	1.68e-03	67	103	3	C0025958
Disease	triacylglycerol 56:3 measurement	FADS1 MAP3K15	1.78e-03	18	103	2	EFO_0010430
Disease	level of Phosphatidylethanolamine (18:0_20:4) in blood serum	MYO1E FADS1	1.99e-03	19	103	2	OBA_2045140
Disease	glucose measurement	ERN1 FADS1 ABCB11 C1QTNF1 MAP3K15 PLCG1	2.20e-03	380	103	6	EFO_0004468
Disease	colorectal cancer (is_marker_for)	AMER1 EEF1E1 GRP PLCG1	2.27e-03	157	103	4	DOID:9256 (is_marker_for)
Disease	total iron binding capacity	FADS1 H4C7 IQCJ-SCHIP1	2.60e-03	78	103	3	EFO_0006334
Disease	triacylglycerol 58:9 measurement	CPOX PTPRT	2.66e-03	22	103	2	EFO_0010443
Disease	Cleft Palate	AMER1 NEDD4L KIF7	2.89e-03	81	103	3	C0008925
Disease	apolipoprotein A 1 measurement	POU6F2 ADAP1 BACE1 NCOA4 CXXC1 FADS1 FES ABCB11 ELL	2.90e-03	848	103	9	EFO_0004614
Disease	triacylglycerol 54:8 measurement	EEF1E1 PTPRT	2.91e-03	23	103	2	EFO_0010426
Disease	coronary artery disease	DPP6 LMNB2 DMXL1 EPG5 SF3B3 FES RPRD2 C1QTNF1 PLCG1 USP48 ELL	3.03e-03	1194	103	11	EFO_0001645
Disease	level of Phosphatidylethanolamine (16:0_18:2) in blood serum	MYO1E FADS1	3.17e-03	24	103	2	OBA_2045136

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYNNKVDEISRRLIW	CTSK	36	P43235
VRLFNVYILWLEDEN	EPG5	1401	Q9HCE0
REWYYEVIIVRVEIN	BACE1	256	P56817
LESQRIYWENKIVRI	BRAP	416	Q7Z569
KRLIAEYDQRQLQAW	ELL	606	P55199
YWSQFDENIRIILKR	RNF20	96	Q5VTR2
KANTYWYREVEREQL	A2ML1	261	A8K2U0
QVDREKIYQWINELS	CNOT9	16	Q92600
QWYEVERTERIKNCL	CPNE3	41	O75131
VERYEKNLVFAQRWG	ABCB11	301	O95342
KQLLYWELRREQLEA	AMER1	566	Q5JTC6
EQWIRAKYERQEFIY	ADAP1	106	O75689
AYDRVEQEWVAIKII	DYRK1A	176	Q13627
VKRLWQYLVKQEEIQ	DMXL1	2591	Q9Y485
LTEDWELFKQRRFIE	FAM193A	156	P78312
LQEWEFLEREVYRVK	MSANTD5	46	A0A3B3IT52
KIIQRAWREYLQRQE	IQCJ	51	Q1A5X6
RRVKVYTLNEDRQWD	PPP4R3A	6	Q6IN85
AWDYRNIIEKLQDVV	ITPR2	1596	Q14571
LWIRETIRKYETQQQ	KLK13	256	Q9UKR3
KIYFIWVTRTQRQFE	DUOX1	1416	Q9NRD9
RRVFKVFLENVIWYA	H4C7	56	Q99525
ILSNWREERYQDDIK	MED12L	1496	Q86YW9
RKLLTQEWVQENYLE	MAGEA8	246	P43361
REVVDWRKYEQEQEK	MTIF2	441	P46199
LRGYIVIEDLWKENF	APOO	171	Q9BUR5
ADLEVKIRDWYQRQR	KRT14	141	P02533
WRIKRQVLEGEEIAY	LMNB2	501	Q03252
RTLINLRVEWEKDYV	ATP12A	896	P54707
RQKWVERIRYVIFDE	DDX60L	856	Q5H9U9
KWRVEYQEDRNDLVI	CAP2	331	P40123
IRQFYINVEREEWKL	EIF4A1	246	P60842
SLKQQLREYIRWEEA	GRP	66	P07492
QQRLVYWLEVALERQ	KIF7	1131	Q2M1P5
YIWIDFLVQRFEIAK	PI4KA	1296	P42356
IWFCVKVVQEYERVI	NPHS2	121	Q9NP85
VFVELWLKNRTLDEY	PRAMEF15	151	P0DUQ1
WIEEKQALYRRNQEL	JAKMIP3	566	Q5VZ66
RNEQSLQEIWDYVKR	L1RE1	141	Q9UN81
FIWRRDVQRVYVELK	EPHB3	96	P54753
RVEKRLYWIDTQRQV	LRP2	3236	P98164
LYWIDTQRQVIERMF	LRP2	3241	P98164
WEVLTEQQKALYREV	POGK	61	Q9P215
RRVKVYTLNEDRQWD	PPP4R3B	6	Q5MIZ7
RRRMVLEFYVQQEWA	IQCF5	56	A8MTL0
VEDYEKQLNRQRIWD	DRC1	266	Q96MC2
WQKRRYNELLFIIDT	PIGK	191	Q92643
VVRRLEKWQEQYDGR	PTPRT	1356	O14522
KRRWEEEYTVRIQLQ	IFFO1	256	Q0D2I5
VWQEREDSVRKYLLQ	OBSCN	5971	Q5VST9
REVWLYEQVDLIYQL	NCOA4	66	Q13772
LKDLFQDYERWVRPV	CHRNA5	51	P30532
VRVWYKLDELFEQER	CXXC1	606	Q9P0U4
VVLKWYENFQRRLAQ	HIKESHI	176	Q53FT3
LKWVQRNAEERERYF	KLHL11	271	Q9NVR0
REQDQVWVRLYKGER	C1QTNF1	241	Q9BXJ1
ERQREQYWEEKEQTL	CARD14	316	Q9BXL6
VLKWYVDRITEAERQ	DOCK4	681	Q8N1I0
WQVERDTYQQLIRKL	GLT1D1	326	Q96MS3
VVAFYVWQREGLRKV	ERN1	226	O75460
IKWEEQTSEQIFRLY	MTFMT	251	Q96DP5
ERVWNLIRYIYNQEE	HLA-DRB4	51	P13762
CEERWLVIDRKVYNI	FADS1	31	O60427
EFLKQIREVWNTYEL	DYNC1H1	1461	Q14204
EEFWVYRALLVELTK	HELQ	986	Q8TDG4
FIYREQKGTVRLWNV	DPP6	156	P42658
ERVRQWEIYVLQNIE	CCDC201	161	A0A1B0GTI1
GQWEALYDEIRQFRK	DERA	166	Q9Y315
ERIFKIWEDRNVYPE	RPRD2	121	Q5VT52
EKLWQQLRRGRYVEF	CPOX	381	P36551
EEKAIVQQWLEYRVT	EEF1E1	66	O43324
IRERQQLRKTYSEQW	FES	106	P07332
RRAILYKILWEEQNQ	MAP3K15	1011	Q6ZN16
WQKFRDLSIEEYIRV	RARS2	241	Q5T160
IRIRWLQIVVRNDYY	RNPEPL1	601	Q9HAU8
QNLREYLEVEWEVKL	SENP7	951	Q9BQF6
VLEEEKNFLLSRIYW	TRIM31	191	Q9BZY9
EIIILKEYVNEEWAR	SH3D19	596	Q5HYK7
AEKLNYDREVVRVWF	POU6F2	641	P78424
VFVELWLKNRTLDEY	PRAMEF27	151	A3QJZ7
VYWQFQRRNEERKEE	SEMA3A	606	Q14563
KIIQRAWREYLQRQE	IQCJ-SCHIP1	51	B3KU38
YEQLVADLLRWIAEK	SPTBN5	311	Q9NRC6
ARKDNVIRLWEYLLE	SPTBN1	501	Q01082
RERIIYIREQWANLE	SPTBN1	716	Q01082
LLNGQVREEYKRWIT	ADGRE1	846	Q14246
VFVELWLKNRTLDEY	PRAMEF4	151	O60810
ELWVQRLKEEYQSLI	UFC1	26	Q9Y3C8
NLRIWDIYIFEGERV	USP6NL	281	Q92738
YRDLQGERQEWKRFI	ZC3H12A	246	Q5D1E8
VLEIWNLVFIQYNRE	AARS1	211	P49588
ETLQQWVKLYRRDLD	TONSL	636	Q96HA7
VFVELWLKNRTLDEY	PRAMEF9	151	P0DUQ2
VWHLQYRDVRVQKVF	ST14	76	Q9Y5Y6
LRELEQQIWKERDEY	TRIM15	191	Q9C019
LQIERWLRKQFYSVD	PLCG1	151	P19174
VFVELWLKNRTLDEY	PRAMEF11	151	O60813
NVVKILREYLEVEWE	SENP6	986	Q9GZR1
IEERYAALLKRWEQL	SPTA1	2006	P02549
FLWFLKRERQEEYIE	SLAMF7	246	Q9NQ25
WVRYKRNENQLIIFA	SF3B3	1011	Q15393
EEWKLLDTAQQIVYR	ZNF10	26	P21506
EEDRRYFKQQEIILW	VPS26A	281	O75436
WKEGRQLLRQYLEEV	STRN4	171	Q9NRL3
EDVYQRIVWLQEKVQ	THOP1	116	P52888
LYRWKQLEESLVIFE	TIGD7	341	Q6NT04
VLYIVSQFFVEEWRK	USP48	741	Q86UV5
RQERTAWKNYIQIER	TRIM22	166	Q8IYM9
YKNLREIVVNNRITW	TDH	106	Q8IZJ6
AYVKLKEQEIRNIVW	ATP6V0D2	316	Q8N8Y2
LKAEQEEYVQEGIRW	MYO1E	421	Q12965
AKAVYQRLFEWVVNR	MYO1G	356	B0I1T2
QQLRAWEAEKYNEIR	PDE4DIP	416	Q5VU43
NENKREYIDLVIQWR	NEDD4L	801	Q96PU5
EYIDLVIQWRFVNRV	NEDD4L	806	Q96PU5