Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC46A2 SLC35C1 SLC35A2 SLC28A2	9.65e-05	59	81	4	GO:1901505
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SLC46A2 SLC35C1 SLC35A2 SLC28A2	9.65e-05	59	81	4	GO:0015932
GeneOntologyMolecularFunction	aspartic endopeptidase activity, intramembrane cleaving	PSEN1 PSEN2	4.48e-04	8	81	2	GO:0042500
GeneOntologyCellularComponent	cell surface	SLC46A2 PSEN1 CEACAM21 CIITA ADGRG2 TREM2 KCNN2 IL17RC TNFRSF11A DCSTAMP ADGRE2 IL3RA BTN2A1 JAM3	1.12e-04	1111	83	14	GO:0009986
GeneOntologyCellularComponent	endoplasmic reticulum membrane	OR8K1 PSEN1 DNAJC14 PSEN2 RAB3GAP2 UBXN8 SLC35A2 UBAC2 LRRC59 DCSTAMP CYP39A1 PGRMC1 MBOAT2 PLPP6 PIGM	1.56e-04	1293	83	15	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	OR8K1 PSEN1 DNAJC14 PSEN2 RAB3GAP2 UBXN8 SLC35A2 UBAC2 LRRC59 DCSTAMP CYP39A1 PGRMC1 MBOAT2 PLPP6 PIGM	1.64e-04	1299	83	15	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	OR8K1 PSEN1 DNAJC14 PSEN2 RAB3GAP2 UBXN8 SLC35A2 UBAC2 LRRC59 DCSTAMP CYP39A1 PGRMC1 MBOAT2 PLPP6 PIGM	2.07e-04	1327	83	15	GO:0042175
GeneOntologyCellularComponent	gamma-secretase complex	PSEN1 PSEN2	3.23e-04	7	83	2	GO:0070765
GeneOntologyCellularComponent	smooth endoplasmic reticulum	PSEN1 KCNN2 PGRMC1	8.10e-04	46	83	3	GO:0005790
HumanPheno	Semantic dementia	PSEN1 PSEN2 TREM2	6.35e-06	7	30	3	HP:0030219
HumanPheno	Finger agnosia	PSEN1 PSEN2 TREM2	6.35e-06	7	30	3	HP:0010525
HumanPheno	Deposits immunoreactive to beta-amyloid protein	PSEN1 PSEN2 TREM2	1.51e-05	9	30	3	HP:0003791
HumanPheno	Anomic aphasia	PSEN1 PSEN2 TREM2	1.51e-05	9	30	3	HP:0030784
HumanPheno	Senile plaques	PSEN1 PSEN2 TREM2	2.95e-05	11	30	3	HP:0100256
Domain	Peptidase_A22A	PSEN1 PSEN2	1.81e-05	2	80	2	IPR001108
Domain	Presenilin	PSEN1 PSEN2	1.81e-05	2	80	2	PF01080
Domain	Fringe-like	C1GALT1 LFNG	1.80e-04	5	80	2	IPR003378
Domain	Fringe	C1GALT1 LFNG	1.80e-04	5	80	2	PF02434
Domain	PSN	PSEN1 PSEN2	3.75e-04	7	80	2	SM00730
Domain	Preselin/SPP	PSEN1 PSEN2	3.75e-04	7	80	2	IPR006639
Domain	V-set	CEACAM21 TREM2 CD300E BTN2A1 JAM3	1.16e-03	184	80	5	PF07686
Domain	Ig_V-set	CEACAM21 TREM2 CD300E BTN2A1 JAM3	1.64e-03	199	80	5	IPR013106
Domain	ConA-like_dom	NBEAL2 TRIM65 BTN2A1 RSPRY1 CRB2	2.50e-03	219	80	5	IPR013320
Pathway	REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3	PSEN1 PSEN2	4.91e-04	8	60	2	M27887
Pathway	REACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS	SLC35C1 SLC35A2	6.29e-04	9	60	2	M27688
Pathway	REACTOME_TRANSPORT_OF_NUCLEOTIDE_SUGARS	SLC35C1 SLC35A2	6.29e-04	9	60	2	MM15421
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC7A2 SLC44A1 SLC39A2 SLC35C1 SLC35A2 SLC28A2	6.45e-04	249	60	6	M5988
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLC35C1 SLC35A2 SLC28A2	6.96e-04	41	60	3	MM15075
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLC35C1 SLC35A2 SLC28A2	8.01e-04	43	60	3	M881
Pathway	WP_NOTCH_SIGNALING_WP268	PSEN1 PSEN2 LFNG	9.16e-04	45	60	3	M39571
Pathway	REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS	PSEN1 PSEN2	9.56e-04	11	60	2	M27882
Pathway	REACTOME_TGFBR3_PTM_REGULATION	PSEN1 PSEN2	9.56e-04	11	60	2	M48251
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	PSEN1 PSEN2	9.56e-04	11	60	2	M47865
Pathway	WP_INCLUSION_BODY_MYOSITIS	PSEN1 PSEN2	9.56e-04	11	60	2	M42545
Pathway	REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR	PSEN1 PSEN2	9.56e-04	11	60	2	M2661
Pathway	WP_NOTCH_SIGNALING_PATHWAY	PSEN1 PSEN2 LFNG	9.77e-04	46	60	3	MM15971
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	PSEN1 PSEN2 LFNG	1.04e-03	47	60	3	M7946
Pubmed	Evaluation of the Clinical Features Accompanied by the Gene Mutations: The 2 Novel PSEN1 Variants in a Turkish Early-onset Alzheimer Disease Cohort.	PSEN1 PSEN2 TREM2	1.26e-08	3	82	3	33769986
Pubmed	Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.	PSEN1 PSEN2 LFNG	2.74e-06	12	82	3	19779553
Pubmed	Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.	PSEN1 PSEN2	5.49e-06	2	82	2	21285369
Pubmed	Novel PSEN1 and PSEN2 Mutations Identified in Sporadic Early-onset Alzheimer Disease and Posterior Cortical Atrophy.	PSEN1 PSEN2	5.49e-06	2	82	2	33973882
Pubmed	Novel role of presenilins in maturation and transport of integrin beta 1.	PSEN1 PSEN2	5.49e-06	2	82	2	18293935
Pubmed	gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.	PSEN1 PSEN2	5.49e-06	2	82	2	16135086
Pubmed	Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.	PSEN1 PSEN2	5.49e-06	2	82	2	12460542
Pubmed	Alzheimer's Disease Associated Presenilin 1 and 2 Genes Dysregulation in Neonatal Lymphocytes Following Perinatal Asphyxia.	PSEN1 PSEN2	5.49e-06	2	82	2	34067945
Pubmed	Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus.	PSEN1 PSEN2	5.49e-06	2	82	2	36710361
Pubmed	Presenilin 1 and 2 are expressed differentially in the cerebral cortex of mice during development.	PSEN1 PSEN2	5.49e-06	2	82	2	22796216
Pubmed	Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex.	PSEN1 PSEN2	5.49e-06	2	82	2	27177724
Pubmed	Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.	PSEN1 PSEN2	5.49e-06	2	82	2	11715026
Pubmed	Clinical Phenotype and Mutation Spectrum of Alzheimer's Disease with Causative Genetic Mutation in a Chinese Cohort.	PSEN1 PSEN2	5.49e-06	2	82	2	34102969
Pubmed	Selective expression of the neurexin substrate for presenilin in the adult forebrain causes deficits in associative memory and presynaptic plasticity.	PSEN1 PSEN2	5.49e-06	2	82	2	34662541
Pubmed	Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.	PSEN1 PSEN2	5.49e-06	2	82	2	10518543
Pubmed	Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice.	PSEN1 PSEN2	5.49e-06	2	82	2	29867447
Pubmed	MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice.	PSEN1 PSEN2	5.49e-06	2	82	2	28879407
Pubmed	Late onset familial Alzheimer's disease: novel presenilin 2 mutation and PS1 E318G polymorphism.	PSEN1 PSEN2	5.49e-06	2	82	2	18350357
Pubmed	Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.	PSEN1 PSEN2	5.49e-06	2	82	2	16620965
Pubmed	Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.	PSEN1 PSEN2	5.49e-06	2	82	2	23365231
Pubmed	Changes in cholesterol metabolism are associated with PS1 and PS2 gene regulation in SK-N-BE.	PSEN1 PSEN2	5.49e-06	2	82	2	17401156
Pubmed	Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.	PSEN1 PSEN2	5.49e-06	2	82	2	36944398
Pubmed	Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	24018889
Pubmed	Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks.	PSEN1 PSEN2	5.49e-06	2	82	2	32992716
Pubmed	Identification of Structural Calcium Binding Sites in Membrane-Bound Presenilin 1 and 2.	PSEN1 PSEN2	5.49e-06	2	82	2	32420742
Pubmed	Presence of a mutation in PSEN1 or PSEN2 gene is associated with an impaired brain endothelial cell phenotype in vitro.	PSEN1 PSEN2	5.49e-06	2	82	2	33413468
Pubmed	Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.	PSEN1 PSEN2	5.49e-06	2	82	2	31167792
Pubmed	Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene.	PSEN1 PSEN2	5.49e-06	2	82	2	7651536
Pubmed	Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	37465679
Pubmed	Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	31376499
Pubmed	Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism.	PSEN1 PSEN2	5.49e-06	2	82	2	18367332
Pubmed	Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.	PSEN1 PSEN2	5.49e-06	2	82	2	29078389
Pubmed	Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria.	PSEN1 PSEN2	5.49e-06	2	82	2	19834068
Pubmed	Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.	PSEN1 PSEN2	5.49e-06	2	82	2	18971484
Pubmed	Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications.	PSEN1 PSEN2	5.49e-06	2	82	2	38227890
Pubmed	Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development.	PSEN1 PSEN2	5.49e-06	2	82	2	25652771
Pubmed	Alpha7 nicotinic acetylcholine receptor agonist PHA-543613 improves memory deficits in presenilin 1 and presenilin 2 conditional double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	36370840
Pubmed	Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients.	PSEN1 PSEN2	5.49e-06	2	82	2	22503161
Pubmed	Age-related neuropsychiatric symptoms in presenilins conditional double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	23792007
Pubmed	Loss of presenilin function enhances tau phosphorylation and aggregation in mice.	PSEN1 PSEN2	5.49e-06	2	82	2	34593029
Pubmed	Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.	PSEN1 PSEN2	5.49e-06	2	82	2	12684521
Pubmed	Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.	PSEN1 PSEN2	5.49e-06	2	82	2	25204494
Pubmed	Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules.	PSEN1 PSEN2	5.49e-06	2	82	2	11987239
Pubmed	Adult neurogenesis is functionally associated with AD-like neurodegeneration.	PSEN1 PSEN2	5.49e-06	2	82	2	17980611
Pubmed	Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.	PSEN1 PSEN2	5.49e-06	2	82	2	16014629
Pubmed	Increased inflammatory response both in brain and in periphery in presenilin 1 and presenilin 2 conditional double knock-out mice.	PSEN1 PSEN2	5.49e-06	2	82	2	19584449
Pubmed	Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling.	PSEN1 PSEN2	5.49e-06	2	82	2	20701429
Pubmed	Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway.	PSEN1 PSEN2	5.49e-06	2	82	2	28619096
Pubmed	Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.	PSEN1 PSEN2	5.49e-06	2	82	2	8574969
Pubmed	In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.	PSEN1 PSEN2	5.49e-06	2	82	2	12846562
Pubmed	Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3.	PSEN1 PSEN2	5.49e-06	2	82	2	8940094
Pubmed	Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release.	PSEN1 PSEN2	5.49e-06	2	82	2	29229705
Pubmed	Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.	PSEN1 PSEN2	5.49e-06	2	82	2	21206757
Pubmed	Notch receptor cleavage depends on but is not directly executed by presenilins.	PSEN1 PSEN2	5.49e-06	2	82	2	11891288
Pubmed	Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.	PSEN1 PSEN2	5.49e-06	2	82	2	8755489
Pubmed	Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.	PSEN1 PSEN2	5.49e-06	2	82	2	37864790
Pubmed	Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.	PSEN1 PSEN2	5.49e-06	2	82	2	10662508
Pubmed	Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	34758364
Pubmed	Ibuprofen partially attenuates neurodegenerative symptoms in presenilin conditional double-knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	24699228
Pubmed	A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.	PSEN1 PSEN2	5.49e-06	2	82	2	14566063
Pubmed	Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease.	PSEN1 PSEN2	5.49e-06	2	82	2	9073509
Pubmed	Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	17499883
Pubmed	Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer's Disease.	PSEN1 PSEN2	5.49e-06	2	82	2	32556937
Pubmed	Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.	PSEN1 PSEN2	5.49e-06	2	82	2	15287885
Pubmed	Novel presenilin mutations within Moroccan patients with Early-Onset Alzheimer's Disease.	PSEN1 PSEN2	5.49e-06	2	82	2	24704512
Pubmed	A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.	PSEN1 PSEN2	5.49e-06	2	82	2	15537629
Pubmed	Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.	PSEN1 PSEN2	5.49e-06	2	82	2	12885769
Pubmed	Age and sex dependent alteration in presenilin expression in mouse cerebral cortex.	PSEN1 PSEN2	5.49e-06	2	82	2	17874292
Pubmed	Role of presenilins in neuronal calcium homeostasis.	PSEN1 PSEN2	5.49e-06	2	82	2	20573903
Pubmed	Two homologous genes causing early-onset familial Alzheimer's disease.	PSEN1 PSEN2	5.49e-06	2	82	2	9246482
Pubmed	A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.	PSEN1 PSEN2	5.49e-06	2	82	2	16103124
Pubmed	Impaired default network functional connectivity in autosomal dominant Alzheimer disease.	PSEN1 PSEN2	5.49e-06	2	82	2	23884042
Pubmed	Molecular genetics of Alzheimer's disease: presenilin 1 gene analysis in a cohort of patients from the Poznań region.	PSEN1 PSEN2	5.49e-06	2	82	2	12817569
Pubmed	Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants.	PSEN1 PSEN2	5.49e-06	2	82	2	28106563
Pubmed	Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.	PSEN1 PSEN2	5.49e-06	2	82	2	17268505
Pubmed	Dimorphic effects of Notch signaling in bone homeostasis.	PSEN1 PSEN2	5.49e-06	2	82	2	18297084
Pubmed	Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.	PSEN1 PSEN2	5.49e-06	2	82	2	15128703
Pubmed	Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors.	PSEN1 PSEN2	5.49e-06	2	82	2	11876645
Pubmed	Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex.	PSEN1 PSEN2	5.49e-06	2	82	2	25429133
Pubmed	Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.	PSEN1 PSEN2	5.49e-06	2	82	2	21414900
Pubmed	Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.	PSEN1 PSEN2	5.49e-06	2	82	2	21914807
Pubmed	Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.	PSEN1 PSEN2	5.49e-06	2	82	2	17614943
Pubmed	Clinical and neuroimaging characterization of Chinese dementia patients with PSEN1 and PSEN2 mutations.	PSEN1 PSEN2	5.49e-06	2	82	2	25323700
Pubmed	Genetic analyses of early-onset Alzheimer's disease using next generation sequencing.	PSEN1 PSEN2	5.49e-06	2	82	2	31182772
Pubmed	Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction.	PSEN1 PSEN2	5.49e-06	2	82	2	20854432
Pubmed	Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.	PSEN1 PSEN2	5.49e-06	2	82	2	17560791
Pubmed	PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach.	PSEN1 PSEN2	5.49e-06	2	82	2	24927704
Pubmed	Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.	PSEN1 PSEN2	5.49e-06	2	82	2	22311977
Pubmed	Abnormalities in periodontal and salivary tissues in conditional presenilin 1 and presenilin 2 double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	20953898
Pubmed	Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.	PSEN1 PSEN2	5.49e-06	2	82	2	18834536
Pubmed	Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.	PSEN1 PSEN2	5.49e-06	2	82	2	28994238
Pubmed	Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.	PSEN1 PSEN2	5.49e-06	2	82	2	22002539
Pubmed	Presence of presenilin 1/2 affects the invasion and replication of Salmonella typhimurium.	PSEN1 PSEN2	5.49e-06	2	82	2	15922300
Pubmed	Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease.	PSEN1 PSEN2	5.49e-06	2	82	2	35949106
Pubmed	Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice.	PSEN1 PSEN2	5.49e-06	2	82	2	18539391
Pubmed	Presenilin mutations in Alzheimer's disease.	PSEN1 PSEN2	5.49e-06	2	82	2	9521418
Pubmed	Biology of presenilins as causative molecules for Alzheimer disease.	PSEN1 PSEN2	5.49e-06	2	82	2	10361981
Pubmed	Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.	PSEN1 PSEN2	5.49e-06	2	82	2	9450754
Pubmed	The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.	PSEN1 PSEN2	5.49e-06	2	82	2	22505025
Pubmed	Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation.	PSEN1 PSEN2	5.49e-06	2	82	2	9298903
Cytoband	Xp22.3	ARSD IL3RA	7.97e-04	23	83	2	Xp22.3
Cytoband	3p21.31	LSMEM2 NBEAL2 DHX30	8.12e-04	100	83	3	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr3p13	GXYLT2 GPR27	3.31e-03	47	83	2	chr3p13
Cytoband	16q24.3	CDH15 SLC22A31	4.04e-03	52	83	2	16q24.3
GeneFamily	Solute carriers	SLC46A2 SLC7A2 SLC44A1 SLC39A2 SLC10A5 SLC35C1 SLC35A2 SLC28A2 SLC22A31	8.64e-06	395	63	9	752
GeneFamily	Beta 3-glycosyltransferases	C1GALT1 LFNG B3GNT8	7.75e-05	24	63	3	426
GeneFamily	Adenosine receptors\|V-set domain containing	CEACAM21 TREM2 CD300E BTN2A1 JAM3	2.58e-04	163	63	5	590
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SLC44A1 KEL TNFRSF11A ADGRE2 IL3RA CD300E	2.46e-03	394	63	6	471
Coexpression	GSE13411_NAIVE_VS_IGM_MEMORY_BCELL_DN	VOPP1 TNFSF9 SLC35C1 ADGRE2 CYP39A1 JAM3 TFF2	2.97e-06	198	82	7	M3240
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	CMTM6 SLC44A1 TNFSF9 SGCB RAB3GAP2 UBXN8 MSH5 THOC2 CYP39A1 MBOAT2 JAM3 PLPP6 TCTN2	3.60e-05	1102	82	13	M2369
Coexpression	GSE3982_BASOPHIL_VS_CENT_MEMORY_CD4_TCELL_UP	RNASE2 SLC44A1 PSEN1 TREM2 ADGRE2 BTN2A1	3.96e-05	200	82	6	M5559
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	CMTM6 SLC44A1 TNFSF9 SGCB RAB3GAP2 UBXN8 MSH5 THOC2 CYP39A1 MBOAT2 JAM3 PLPP6 TCTN2	4.41e-05	1124	82	13	MM1070
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG2 TREM2 KEL TNFRSF11A DCSTAMP	1.24e-05	162	82	5	2787be283b7a705647058aeb9bc54006ce5ffe95
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA TNFRSF11A DCSTAMP CD300E LFNG	1.32e-05	164	82	5	758e85e2f5e7236b345e16c78344d5e0bf17d8dc
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC46A2 TNFRSF11A ADGRE2 CD300E LFNG	1.52e-05	169	82	5	c3d410a5e98000ba872141b62e17ef4ed3d1a8eb
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC46A2 RNASE2 ADGRE2 CD300E SLC22A31	1.57e-05	170	82	5	1c3c03821c90d41de92fef3278f71093a7fd709c
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	RNASE2 TREM2 TNFRSF11A IL3RA CD300E	2.54e-05	188	82	5	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	RNASE2 TREM2 TNFRSF11A IL3RA CD300E	2.54e-05	188	82	5	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RNASE2 ADGRE2 CD300E ADAMTSL4 ERVFRD-1	2.60e-05	189	82	5	2aebea7a6c2f83112d7c504b742f2c04b92e459a
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNASE2 CIITA GPR42 ADGRE2 CD300E	2.60e-05	189	82	5	984b5f21e84dd8273d8437ac2a5a9de4e9484b9a
ToppCell	droplet-Marrow-nan-21m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC35C1 TREM2 CYP39A1 IL3RA B3GNT8	2.67e-05	190	82	5	6c6d3259e23ec90c08756f500ae8a7aff8b8a5b3
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte1_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RNASE2 CIITA DCSTAMP ADGRE2 CD300E	2.74e-05	191	82	5	79c83a710aa17fc06f286e4ea2011ed9e30e3bc6
ToppCell	Smart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_monocytic\|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CMTM6 RNASE2 NBEAL2 ADGRE2 CD300E	3.02e-05	195	82	5	ae98215b7b7f22f1aca690920ce6092dc4a3c7db
ToppCell	Smart-seq2-thymus_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte\|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CMTM6 RNASE2 NBEAL2 ADGRE2 CD300E	3.02e-05	195	82	5	6fcab7aa4db958ccad0300adea9aaae52ace5bff
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	RNASE2 TREM2 ADGRE2 CD300E B3GNT8	3.10e-05	196	82	5	7c8aa5853d7096628e35af665097c0299c329753
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNASE2 TREM2 ADGRE2 CD300E B3GNT8	3.10e-05	196	82	5	f60b220ed117bcc33e0f7bbf5b53d3b1422ebaca
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNASE2 TREM2 ADGRE2 CD300E B3GNT8	3.10e-05	196	82	5	bcd274db4955ea76ca26267a272c7d1929db24f4
ToppCell	3'_v3-Lung-Myeloid_Monocytic-Nonclassical_monocytes\|Lung / Manually curated celltypes from each tissue	CMTM6 GPR42 ADGRE2 CD300E LFNG	3.10e-05	196	82	5	7fe97109a5a06b35fc081a85f341ea78da131323
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNASE2 TREM2 ADGRE2 CD300E B3GNT8	3.10e-05	196	82	5	80b9139d91dda4de69830d2d443859e047ab5503
ToppCell	Mild_COVID-19-Myeloid-MoAM1\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	RNASE2 TREM2 ADGRE2 CD300E B3GNT8	3.10e-05	196	82	5	ea3fbe81b4ecb6ccc8031f6d99da93c9f9f8c1aa
ToppCell	control-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SLC46A2 CIITA KEL CD300E ADAMTSL4	3.25e-05	198	82	5	35499a5231818e3432cf69b5c4a58c02f7771db8
ToppCell	Severe_COVID-19-Myeloid-MoAM3\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	RNASE2 SLC44A1 IL3RA CD300E ADAMTSL4	3.33e-05	199	82	5	30523cf08815ca214877e33a2c52197ff8318557
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CIITA TREM2 DCSTAMP ADGRE2 ADAMTSL4	3.33e-05	199	82	5	98c0d57c247d39bc771d81f4387f8dd01222628e
ToppCell	BAL-Severe-Myeloid-MoAM-MoAM3\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RNASE2 SLC44A1 IL3RA CD300E ADAMTSL4	3.33e-05	199	82	5	105709b97c55826a852aed27658e3b4af1738c8a
ToppCell	BAL-Severe-Myeloid-MoAM-MoAM3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNASE2 SLC44A1 IL3RA CD300E ADAMTSL4	3.33e-05	199	82	5	0892957a49304ce4b6daa3657d76d8365ce0dd19
ToppCell	BAL-Severe-Myeloid-MoAM-MoAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNASE2 SLC44A1 IL3RA CD300E ADAMTSL4	3.33e-05	199	82	5	b2dc3d0af6ecd3ab01779aaa1f061cb0f941cae8
ToppCell	BAL-Severe-Myeloid-MoAM-MoAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNASE2 SLC44A1 IL3RA CD300E ADAMTSL4	3.33e-05	199	82	5	961ad44199871be8e09d31904d383edc865ba262
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CIITA TREM2 DCSTAMP ADGRE2 ADAMTSL4	3.33e-05	199	82	5	b818d46a39c8782188d82dc8931b8eec9d549dd1
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RNASE2 CIITA TREM2 ADGRE2 CD300E	3.41e-05	200	82	5	1a080564de59abd59d3208a73441b6346e1c7cd8
ToppCell	Tracheal-10x5prime-Immune_Myeloid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNASE2 CIITA TREM2 ADGRE2 CD300E	3.41e-05	200	82	5	fc6aebc20ecaa67606154540a691242dc0aea867
ToppCell	mLN-(6)_Macrophage-(61)_LYVE1_Macrophage\|mLN / shred on region, Cell_type, and subtype	RNASE2 TREM2 ADGRE2 CD300E ADAMTSL4	3.41e-05	200	82	5	a20f5ec61d492d8a2adf695ec304b5d57296aa8f
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|mLN / Region, Cell class and subclass	RNASE2 TREM2 ADGRE2 CD300E ADAMTSL4	3.41e-05	200	82	5	89cf739a3c2f5d30e547404f2f2ec6500cd1d65d
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_other\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNASE2 CIITA TREM2 ADGRE2 CD300E	3.41e-05	200	82	5	1438b84096de9b4abe9e6213caa07f6bdff67358
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature\|E18.5-samps / Age Group, Lineage, Cell class and subclass	RNASE2 FBXO24 ADGRG2 CD300E	1.10e-04	134	82	4	a4b9163af68e92d047b0005fd2f98aa63846b65b
ToppCell	remission-multiplets\|remission / disease stage, cell group and cell class	FBXO24 SERINC4 SLC28A2 SLC22A31	1.65e-04	149	82	4	e9974260a5f2999b363f306cae005698c912893a
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PHKB RNASE2 CIITA PLPP6	1.65e-04	149	82	4	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PHKB RNASE2 CIITA PLPP6	1.70e-04	150	82	4	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNASE2 ADGRE2 IL3RA CD300E	1.83e-04	153	82	4	5fbb90b8477f9fdabf3be19efd3068fbf70abee6
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNASE2 ADGRE2 IL3RA CD300E	1.83e-04	153	82	4	2c46183481e6d5a7fa190a743062509465f88e56
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	RNASE2 ADGRE2 IL3RA CD300E	1.83e-04	153	82	4	decc4f3098a9374a6b65c015a9d36380986290bf
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNASE2 ADGRE2 IL3RA CD300E	1.83e-04	153	82	4	36a28805c0545c2f410c74a6ca0a70d840e75715
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA DCSTAMP ADGRE2 CD300E	1.88e-04	154	82	4	1e088b0d4a44267f46a9b643f46a1aba784686b1
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	TREM2 DCSTAMP IL3RA ADAMTSL4	1.92e-04	155	82	4	03fd443740272dcb547e39deaf7ae89b8307f241
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	TREM2 DCSTAMP CD300E ADAMTSL4	1.92e-04	155	82	4	84221a285277292f7225eb69508c887541abeed1
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CIITA GPR42 ADGRE2 CD300E	1.92e-04	155	82	4	77ae0b8d30bc3db4a73fd5340f99691a73d2684f
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA C1GALT1 TNFRSF11A LFNG	2.02e-04	157	82	4	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR27 CIITA ADGRE2 B3GNT8	2.12e-04	159	82	4	323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	LSMEM2 TREM2 IL3RA ADAMTSL4	2.22e-04	161	82	4	5cd483b73bcb3615ea56eb81c1c293e61b84b66d
ToppCell	Mild_COVID-19-Myeloid-MoAM2\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	RNASE2 ADGRE2 IL3RA CD300E	2.28e-04	162	82	4	e5fc80ab19d513af6a7e677a5e67bfebca2e963b
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	KCNN2 ADGRE2 CD300E TFF2	2.39e-04	164	82	4	3c15e9b8403b03d67f6ecd7861dc19f1261e3244
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFDC3 VOPP1 SERINC4 KEL	2.39e-04	164	82	4	f3772227f5aa75a3672d945f8d5bf3fa0b4e456b
ToppCell	PND01-03-samps-Myeloid-Macrophage\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SLC7A2 RNASE2 SLC39A2 TREM2	2.39e-04	164	82	4	49733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCell	droplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA TNFSF9 DCSTAMP CRB2	2.50e-04	166	82	4	c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCell	CTRL-Myeloid-Monocyte\|CTRL / Disease state, Lineage and Cell class	RNASE2 GPR42 ADGRE2 CD300E	2.61e-04	168	82	4	13dca90c7b811e4d5e8fa44f5e892e29be9787a6
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBEAL2 CD300E LFNG PEX26	2.61e-04	168	82	4	e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCell	droplet-Marrow-BM-30m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VOPP1 KEL MBOAT2 LFNG	2.67e-04	169	82	4	8e7a30eb546fc6fa184ebb76f54b74b278005a84
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RNASE2 CEACAM21 TREM2 MSH5	2.67e-04	169	82	4	818ab7a6fd1940a22d3bd99fe15f0af888af6b3e
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-7\|TCGA-Lung / Sample_Type by Project: Shred V9	ARSD LRRC31 B3GNT8 SLC22A31	2.67e-04	169	82	4	5f522a10b6ec24a353f53bec2f779a81cd5f9581
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RNASE2 CEACAM21 TREM2 MSH5	2.67e-04	169	82	4	f982f2e0d341fa27229f443ebe5c0e4a9e63bda6
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIITA TNFSF9 DCSTAMP CRB2	2.67e-04	169	82	4	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Ptprz1_(Ptprz1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SMIM9 SLC10A5 WNT2B	2.68e-04	68	82	3	9ce22a6dea3c17d5352572ea0dabe6c6120b9f82
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Ptprz1_(Ptprz1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SMIM9 SLC10A5 WNT2B	2.68e-04	68	82	3	89d337147899a978a7467db24e876a613bdd2288
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM219 TNFSF9 TREM2 RSPRY1	2.74e-04	170	82	4	7534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG2 TREM2 TNFRSF11A DCSTAMP	2.74e-04	170	82	4	8d3c51364a332020810836e2055c60893c10d7f3
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|390C / Donor, Lineage, Cell class and subclass (all cells)	GPR27 CIITA TREM2 IL3RA	2.74e-04	170	82	4	3a7121d045f9ae54583b0f5f7436abf3665a1bce
ToppCell	Monocytes-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	RNASE2 ADGRE2 CD300E LFNG	2.74e-04	170	82	4	4e93b66b3033e6e4d5f6d2f41974623a53108f5e
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage\|368C / Donor, Lineage, Cell class and subclass (all cells)	CIITA TREM2 IL3RA ADAMTSL4	2.92e-04	173	82	4	bba8265a58f8f5659dc7b9da2fe27b15033fce34
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	WNT2B HRCT1 KCNN2 CRB2	2.92e-04	173	82	4	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Alveolar_Mac\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	TREM2 DCSTAMP IL3RA ADAMTSL4	2.92e-04	173	82	4	4efa0878ed1ede8fa5d6c191a76d4f70558ba761
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG2 MROH2B WNT2B ADAMTSL4	2.92e-04	173	82	4	11e95a60b5f6f07f27154a23203bac431e7528c6
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	CIITA SLC35A2 ADGRE2 IL3RA	3.12e-04	176	82	4	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC46A2 CIITA ADGRE2 CD300E	3.12e-04	176	82	4	926ed37e636fe4dd3a18731cea15761f0c2c285a
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Macrophage\|GI_small-bowel / Manually curated celltypes from each tissue	TREM2 DCSTAMP IL3RA ADAMTSL4	3.12e-04	176	82	4	4be270f6bb7da4070f972aca403109751646d155
ToppCell	Monocytes-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	RNASE2 GPR27 ADGRE2 CD300E	3.12e-04	176	82	4	5b5f8655b0c6c56f98f70bce13e71f017d4b75a5
ToppCell	VE-mono2-\|VE / Condition, Cell_class and T cell subcluster	RNASE2 MROH2B HRCT1 TREM2	3.40e-04	180	82	4	188e7c65e9a86771f89029b18dfb3216b2c9d7d7
ToppCell	VE-mono2\|VE / Condition, Cell_class and T cell subcluster	RNASE2 MROH2B HRCT1 TREM2	3.40e-04	180	82	4	494d00672f20ceffa7054a31e617fb7ec72e56e9
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Igfbp4\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SLC46A2 SMIM9 CIITA	3.45e-04	74	82	3	08874e430b4c9fcb2c1758c4178cb0c45671b125
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC46A2 RNASE2 ADGRE2 CD300E	3.47e-04	181	82	4	8657d35cd3dff6c89d0fde67d7e7e81e1d6c8884
ToppCell	5'-Adult-LymphNode-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNASE2 GPR27 ADGRE2 CD300E	3.54e-04	182	82	4	1fb9bdf2e9f0a9c230f109b471672f9c31e27c82
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC7A2 RNASE2 SLC35C1 TNFRSF11A	3.54e-04	182	82	4	57f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC44A1 KCNN2 CSMD1 MBOAT2	3.54e-04	182	82	4	82ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CEACAM21 KCNN2 TNFRSF11A IL3RA	3.54e-04	182	82	4	f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCell	cellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	VOPP1 CIITA OR5H6 TNFRSF11A	3.62e-04	183	82	4	e01dacb08a9c36cf09c0b6764ce032a7232d4cdc
ToppCell	wk_08-11-Hematologic-Myeloid-Non-cla._mono.\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SLC46A2 TREM2 ADGRE2 CD300E	3.69e-04	184	82	4	324f91b70913bda3509e234aaf23b46fad91e076
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GXYLT2 SLC7A2 FBXO24 IL17RC	3.69e-04	184	82	4	235890e8b424f4386b6ea52d173d20a00898df73
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNASE2 GPR42 TNFRSF11A ADGRE2	3.69e-04	184	82	4	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	UBAC2 CSMD1 ADGRE2 CD300E	3.69e-04	184	82	4	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC46A2 RNASE2 ADGRE2 CD300E	3.77e-04	185	82	4	00a991e63e9ac6de3f48a96e3be6073f90cbb442
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNASE2 GPR42 ADGRE2 CD300E	3.77e-04	185	82	4	f8de11dd53b34d36368a2082f24ec1416cb7dbae
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBEAL2 HRCT1 TNFRSF11A MBOAT2	3.85e-04	186	82	4	4046b701aa29712d9f7c774f8955215122c3c003
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CMTM6 DNAJC14 SLC35A2 TREM2	3.85e-04	186	82	4	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNFRSF11A ADGRE2 CD300E ADAMTSL4	3.85e-04	186	82	4	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	Myeloid-B_(Activated_Macrophage)\|World / shred on cell class and cell subclass (v4)	SLC7A2 RNASE2 PSEN2 SLC35C1	3.85e-04	186	82	4	33d731a7883d75e4e7db83b641cdb1e9a39938bf
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNASE2 GPR42 ADGRE2 CD300E	3.85e-04	186	82	4	0859737021747518731aa67fe181d4ca4fdc0721
ToppCell	5'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBEAL2 HRCT1 TNFRSF11A MBOAT2	3.85e-04	186	82	4	bd5837033c1ffcbe5dd30195cc4846a2ba351bcd
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TNFRSF11A ADGRE2 CD300E ADAMTSL4	3.85e-04	186	82	4	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFDC3 CYP39A1 ADAMTSL4 TFF2	3.92e-04	187	82	4	9aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CMTM6 DNAJC14 SLC35A2 TREM2	3.92e-04	187	82	4	816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG2 TNFSF9 C1GALT1 ADAMTSL4	4.00e-04	188	82	4	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	SLC44A1 UBAC2 ADGRE2 CD300E	4.09e-04	189	82	4	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	SLC44A1 UBAC2 ADGRE2 CD300E	4.09e-04	189	82	4	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	368C-Myeloid-Macrophage\|368C / Donor, Lineage, Cell class and subclass (all cells)	CEACAM21 TREM2 IL3RA ADAMTSL4	4.09e-04	189	82	4	e62355be0d136e2b7c739848022292e9c6af7392
Disease	Alzheimer's disease 3 (implicated_via_orthology)	PSEN1 PSEN2	6.90e-06	2	78	2	DOID:0110042 (implicated_via_orthology)
Disease	bowel opening frequency	FBXO24 GPR42 LFNG	6.85e-05	30	78	3	EFO_0600084
Disease	early-onset Parkinson's disease (implicated_via_orthology)	PSEN1 PSEN2	1.03e-04	6	78	2	DOID:0060894 (implicated_via_orthology)
Disease	Asphyxia Neonatorum	PSEN1 PSEN2	1.03e-04	6	78	2	C0004045
Disease	Acute Confusional Senile Dementia	PSEN1 PSEN2 TREM2 PGRMC1	1.41e-04	99	78	4	C0546126
Disease	Alzheimer's Disease, Focal Onset	PSEN1 PSEN2 TREM2 PGRMC1	1.41e-04	99	78	4	C0750900
Disease	Alzheimer Disease, Early Onset	PSEN1 PSEN2 TREM2 PGRMC1	1.41e-04	99	78	4	C0750901
Disease	Presenile dementia	PSEN1 PSEN2 TREM2 PGRMC1	1.41e-04	99	78	4	C0011265
Disease	Alzheimer Disease, Late Onset	PSEN1 PSEN2 TREM2 PGRMC1	1.41e-04	99	78	4	C0494463
Disease	Frontotemporal dementia	PSEN1 TREM2	1.44e-04	7	78	2	C0338451
Disease	Semantic Dementia	PSEN1 TREM2	1.44e-04	7	78	2	C0338462
Disease	Early-onset autosomal dominant Alzheimer disease	PSEN1 PSEN2	1.44e-04	7	78	2	cv:CN043596
Disease	Familial Alzheimer Disease (FAD)	PSEN1 PSEN2 TREM2 PGRMC1	1.46e-04	100	78	4	C0276496
Disease	Alzheimer's Disease	PSEN1 PSEN2 TREM2 PGRMC1	1.52e-04	101	78	4	C0002395
Disease	Alzheimer disease	PSEN1 PSEN2	1.91e-04	8	78	2	cv:C0002395
Disease	Primary Progressive Nonfluent Aphasia	PSEN1 TREM2	1.91e-04	8	78	2	C0751706
Disease	Behavioral variant of frontotemporal dementia	PSEN1 TREM2	2.45e-04	9	78	2	C4011788
Disease	Osteitis Deformans	TNFRSF11A DCSTAMP	2.45e-04	9	78	2	C0029401
Disease	Cardiomyopathy, Dilated	PSEN1 PSEN2 SGCB	2.82e-04	48	78	3	C0007193
Disease	Alzheimer's disease (implicated_via_orthology)	PSEN1 PSEN2 TM2D2	4.69e-04	57	78	3	DOID:10652 (implicated_via_orthology)
Disease	osteitis deformans	TNFRSF11A DCSTAMP	5.28e-04	13	78	2	EFO_0004261
Disease	Dementia	PSEN2 TREM2	9.14e-04	17	78	2	C0497327
Disease	L-arginine measurement	SLC7A2 ADGRG2	2.32e-03	27	78	2	EFO_0006524

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSLPVLLFLCLLLKT	ARSD	16	P51689
QCLLLLLDAFGLLES	ANAPC2	106	Q9UJX6
YLLLLLSLPQLCLDQ	ADAMTSL4	11	Q6UY14
RFQSLLLLLGLLVLC	CSMD1	6	Q96PZ7
LLLAALTFLLCKAIQ	ADGRE2	551	Q9UHX3
GLFQKKLLRGCTLLL	CIITA	531	P33076
LVAALVCFLLLRKTG	CEACAM21	251	Q3KPI0
ALLLLCLSGCLSLKG	CD300E	6	Q496F6
PSKILIQLCAALLLL	ADGRG2	661	Q8IZP9
IQLCAALLLLNLVFL	ADGRG2	666	Q8IZP9
ALLFCTVGILLRKLQ	DHX30	531	Q7L2E3
CLILLLAGLLSFGVK	SLC7A2	171	P52569
LLSCLNNLFLLLKEL	ITSN2	636	Q9NZM3
GLLQFCANKLKLLQL	RAB3GAP2	631	Q9H2M9
TRFLKLLGALLLLAL	DNAJC14	321	Q6Y2X3
LALAGALLACLLVLT	LFNG	11	Q8NES3
KLLVCGLSLLFHLTI	MBOAT2	236	Q6ZWT7
AVLKLLLLLLLFGVA	LRRC59	246	Q96AG4
CACLLLLLLGLLSGI	CRB2	1231	Q5IJ48
LCLLLIIGLFANLSS	GPR155	661	Q7Z3F1
KCLISLSTIILLGLI	KCNN2	171	Q9H2S1
VLLLLLLLATCLFHG	HRCT1	21	Q6UXD1
AALGLKLATLSLLLC	GPR27	16	Q9NS67
LLKLACSDTFLIGLL	OR4X2	176	Q8NGF9
NLLLLGLCIFLLYKI	PGRMC1	31	O00264
PFKKSLLAALILCLL	PEX26	251	Q7Z412
KNLGLFFLPILIHLC	DCSTAMP	291	Q9H295
KAAALLLLALAALLL	GXYLT2	6	A0PJZ3
CVGGNLKLLLETLKL	LRRC31	406	Q6UY01
LLLFRGCLIGAVNLK	JAM3	21	Q9BX67
LNLLALVVFVGKLRC	GPR42	31	O15529
SCLGVQCLLLSLLLL	PCDHA10	6	Q9Y5I2
LCIQLLVLSFIGGLL	OR5H6	156	Q8NGV6
LLLKKVLFALCALNA	FAM189A2	81	Q15884
VNACILFLPLLLLLG	SLC35C1	236	Q96A29
LTLLLIALPCLLQTK	IL3RA	6	P26951
LLLLLSLCALVSAQF	BTN2A1	16	Q7KYR7
LALSLPAKILFCALG	FBXO24	351	O75426
GGFLLLLALLVLTCL	LSMEM2	96	Q8N112
SKEIILGLCLLSLVL	SLC44A1	211	Q8WWI5
LLCSQLFSILLGEKV	C1GALT1	21	Q9NS00
ILGCLALFLLLQRKN	CYP39A1	11	Q9NYL5
CLLCLSALLTLLGLK	B3GNT8	6	Q7Z7M8
FASLAVLALLCVLLL	SLC22A31	491	A6NKX4
LLVLGLLAQSLCLSL	CDH15	6	P55291
CLLFAAALSLILLLK	IL17RC	546	Q8NAC3
CLASQAILLGILLKR	PHKB	736	Q93100
CLLTVRALGGLLKFL	MSH5	176	O43196
LLSPGILEYLLQCLK	RSPRY1	221	Q96DX4
IGLCLTLLLLAIFKK	PSEN1	416	P49768
EQALLLLKLFIILCR	NBEAL2	76	Q6ZNJ1
LELIILIFSGCNLLF	OR8K1	201	Q8NGG5
KGNLAICVIILLFIL	SGCB	61	Q16585
ELFTLLLKLVSCTLG	MROH2B	1161	Q7Z745
LILPLILLNKCAFGC	SLC10A5	146	Q5PT55
FTSQICLLLLLGLLA	RNASE2	6	P10153
LFKKILLGLLCLAYA	SLC28A2	76	O43868
VLKGLTCLLLLFAQK	SLC35A2	76	P78381
GIKLGCLFALLALTL	SLC39A2	6	Q9NP94
LKGLQLLLSLLAFIC	CMTM6	41	Q9NX76
LFLLKALLALGSLES	WFDC3	6	Q8IUB2
AKVAALLLGLLLECT	VOPP1	6	Q96AW1
LLLCGQAALLLGNLL	TM2D2	11	Q9BX73
LILENIKSLIGCFNL	THOC2	191	Q8NI27
VSLLLLLLFGPCLLN	ERVFRD-1	491	P60508
LLIIGFLLCSLTCLL	SMIM9	6	A6NGZ8
LLKLLFLLGLCAIAF	SERINC4	156	A6NH21
AQLLAALLVLGLCAL	TFF2	6	Q03403
LIGLCLTLLLLAVFK	PSEN2	396	P49810
LLLLACIFLIKILAA	TREM2	176	Q9NZC2
LVAGLLLLLLLAAAC	TNFSF9	31	P41273
FALLLDLLLVALIKG	PLPP6	171	Q8IY26
LAVLTCGLFLILLAL	ZDHHC23	171	Q8IYP9
FLLSRLGLLLKVLLD	SLC46A2	116	Q9BY10
VCATLILLLLGLSGL	TMEM219	21	Q86XT9
LSLLLALLLPHCQKL	UBAC2	26	Q8NBM4
ICFLTDQLLLILVGK	WDCP	391	Q9H6R7
LKQLLSRLCGLLLEE	TRIM65	276	Q6PJ69
LAGLFFLLINCSILI	PIGM	391	Q9H3S5
SLECLLGLLSLLLVK	TMEM271	226	A0A286YF58
SQCVAKGLLLLLFLT	TCTN2	666	Q96GX1
IKDFLLLCGRILLLL	UBXN8	31	O00124
SARLGLACLLLLLLL	WNT2B	36	Q93097
LFALLLLCALLARLQ	TNFRSF11A	11	Q9Y6Q6
AILILGLLLCFSVLL	KEL	51	P23276