Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	HEXA SPAM1 GALC TREH IDUA GAA KLB	1.29e-07	103	76	7	GO:0004553
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	HEXA SPAM1 GALC TREH IDUA GAA KLB	1.26e-06	144	76	7	GO:0016798
GeneOntologyBiologicalProcess	maintenance of location in cell	HEXA DRD1 ABL1 ASPM TSPO TWF2 FASLG GAA GP5	3.25e-07	259	73	9	GO:0051651
GeneOntologyBiologicalProcess	maintenance of location	HEXA DAND5 DRD1 ABL1 ASPM TSPO TWF2 FASLG GAA GP5	1.29e-06	396	73	10	GO:0051235
GeneOntologyBiologicalProcess	disaccharide metabolic process	TREH IDUA GAA	9.15e-06	12	73	3	GO:0005984
GeneOntologyCellularComponent	lysosomal lumen	HEXA GALC IDUA FASLG GAA	2.72e-05	98	75	5	GO:0043202
GeneOntologyCellularComponent	vacuolar lumen	HEXA GALC IDUA FASLG GAA	4.51e-04	178	75	5	GO:0005775
Domain	Glycoside_hydrolase_SF	HEXA SPAM1 GALC IDUA GAA KLB	5.28e-08	53	72	6	IPR017853
Domain	-	HEXA GALC IDUA KLB	9.71e-06	35	72	4	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	HEXA GALC IDUA KLB	1.36e-05	38	72	4	IPR013781
Domain	ARM-type_fold	HGH1 PIK3C2B INTS1 ASPM XPO4 USP35	1.95e-03	339	72	6	IPR016024
Domain	Hemopexin-like_dom	MMP28 HPX	3.52e-03	23	72	2	IPR000585
Domain	Hemopexin-like_repeat	MMP28 HPX	3.52e-03	23	72	2	IPR018487
Domain	Hemopexin	MMP28 HPX	3.52e-03	23	72	2	PF00045
Domain	HEMOPEXIN	MMP28 HPX	3.52e-03	23	72	2	PS00024
Domain	-	MMP28 HPX	3.52e-03	23	72	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP28 HPX	3.52e-03	23	72	2	PS51642
Domain	HX	MMP28 HPX	3.52e-03	23	72	2	SM00120
Domain	fn3	PTPRO ROBO1 OSMR USH2A	3.55e-03	162	72	4	PF00041
Domain	CTCK_2	DAND5 SSPOP	4.15e-03	25	72	2	PS01225
Domain	FN3	PTPRO ROBO1 OSMR USH2A	5.68e-03	185	72	4	SM00060
Domain	FN3	PTPRO ROBO1 OSMR USH2A	7.32e-03	199	72	4	PS50853
Pathway	KEGG_GLYCOSAMINOGLYCAN_DEGRADATION	HEXA SPAM1 IDUA	6.01e-05	21	52	3	M3624
Pubmed	Pilot study of newborn screening for six lysosomal storage diseases using Tandem Mass Spectrometry.	GALC IDUA GAA	2.08e-07	6	77	3	27238910
Pubmed	Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1.	USP35 SNAI1	4.84e-06	2	77	2	38250150
Pubmed	The role of MAPK-ERK pathway in 67-kDa laminin receptor-induced FasL expression in human cholangiocarcinoma cells.	RPSA FASLG	4.84e-06	2	77	2	20101459
Pubmed	Reelin is involved in transforming growth factor-β1-induced cell migration in esophageal carcinoma cells.	RELN SNAI1	1.45e-05	3	77	2	22393371
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	COG1 INTS1 USP35 KCNT1 SYT13	2.36e-05	153	77	5	10718198
Pubmed	N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.	HGH1 FAM111B	2.89e-05	4	77	2	22814378
Pubmed	Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis.	BMP4 SNAI1	2.89e-05	4	77	2	14699574
Pubmed	Development and maturation of invariant NKT cells in the presence of lysosomal engulfment.	GALC IDUA	4.82e-05	5	77	2	19637231
Pubmed	Animal models of lysosomal disease: an overview.	HEXA GALC	7.22e-05	6	77	2	9728334
Pubmed	The role of Robo3 in the development of cortical interneurons.	RELN ROBO1	7.22e-05	6	77	2	19366869
Pubmed	Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.	BMP4 RELN ROBO1	8.32e-05	38	77	3	18579678
Pubmed	Molecular mechanisms of cleft lip formation in CL/Fr mice.	BMP4 SNAI1	1.34e-04	8	77	2	18830900
Pubmed	Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.	ABL1 ROBO1	1.34e-04	8	77	2	10892742
Pubmed	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	ABL1 STS CHEK2 FASLG	1.36e-04	117	77	4	19124506
Pubmed	Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia.	BMP4 RELN	1.72e-04	9	77	2	12668639
Pubmed	Axis development and early asymmetry in mammals.	HEXA BMP4	1.72e-04	9	77	2	9988215
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	ROBO1 USH2A	1.72e-04	9	77	2	23144817
Pubmed	Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.	BMP4 SNAI1	1.72e-04	9	77	2	19648291
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERV3-1 ERVFC1-1	2.15e-04	10	77	2	12970426
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	HEXA AUNIP ARHGEF10 PROSER3 NFRKB ROBO1 ALDH9A1 GGCX	2.19e-04	733	77	8	34672954
Pubmed	Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.	BMP4 SNAI1	2.63e-04	11	77	2	27297885
Pubmed	Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.	ABL1 ALK	2.63e-04	11	77	2	16135792
Pubmed	The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure.	BMP4 SNAI1	3.15e-04	12	77	2	17442300
Pubmed	Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway.	BMP4 RELN	3.15e-04	12	77	2	11719201
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERV3-1 ERVFC1-1	3.15e-04	12	77	2	14557543
Pubmed	Bmp signaling represses Vegfa to promote outflow tract cushion development.	BMP4 SNAI1	3.15e-04	12	77	2	23863481
Pubmed	RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects.	BMP4 SNAI1	3.15e-04	12	77	2	30061196
Pubmed	Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.	RELN ROBO1	3.71e-04	13	77	2	31070778
Pubmed	Genome-wide analysis of gene transcription in the hypothalamus.	MAGEL2 PTPRO	3.71e-04	13	77	2	15870395
Pubmed	Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.	BMP4 SNAI1	4.33e-04	14	77	2	15525667
Pubmed	NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development.	BMP4 SNAI1	4.33e-04	14	77	2	32655758
Pubmed	Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis.	RELN SNAI1	4.33e-04	14	77	2	25245104
Pubmed	Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis.	BMP4 SNAI1	4.33e-04	14	77	2	17075876
Pubmed	Differential gene expression in migratory streams of cortical interneurons.	RELN PTPRO	4.33e-04	14	77	2	22103416
Pubmed	Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse.	BMP4 DAND5	4.99e-04	15	77	2	12361961
Pubmed	Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression.	RELN MAGEL2	4.99e-04	15	77	2	23523356
Pubmed	The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes.	BMP4 RELN	4.99e-04	15	77	2	17928452
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	ABL1 CHEK2 ALK	5.35e-04	71	77	3	28319113
Pubmed	Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development.	BMP4 SNAI1 FASLG	5.58e-04	72	77	3	37702066
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	BMP4 SNAI1 SSPOP	6.28e-04	75	77	3	20637190
Pubmed	Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.	BMP4 RELN	6.44e-04	17	77	2	22461901
Pubmed	Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.	BMP4 DAND5	6.44e-04	17	77	2	18697220
Pubmed	Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.	RELN ROBO1	6.44e-04	17	77	2	17376983
Pubmed	Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.	RELN ASPM	7.23e-04	18	77	2	28272472
Pubmed	Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice.	DAND5 SNAI1	7.23e-04	18	77	2	16801545
Pubmed	Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.	BMP4 SNAI1	7.23e-04	18	77	2	22912414
Pubmed	BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.	BMP4 DAND5	8.07e-04	19	77	2	18981480
Pubmed	The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.	BMP4 SNAI1	8.07e-04	19	77	2	16950123
Pubmed	FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical Connections.	RELN ROBO1	8.96e-04	20	77	2	30392794
Pubmed	Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels.	RELN ROBO1	8.96e-04	20	77	2	29961574
Pubmed	Early dorsomedial tissue interactions regulate gyrification of distal neocortex.	BMP4 RELN	9.89e-04	21	77	2	31729356
Pubmed	Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.	BMP4 SNAI1	9.89e-04	21	77	2	23055936
Pubmed	Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala.	RELN DRD1 MAGEL2	1.00e-03	88	77	3	21491433
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	ACY1 KCNT1	1.09e-03	22	77	2	26494785
Pubmed	Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation.	BMP4 SNAI1	1.09e-03	22	77	2	22669107
Pubmed	Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning.	BMP4 SNAI1	1.19e-03	23	77	2	19235731
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	BMP4 RELN HGH1 TWF2	1.24e-03	210	77	4	16537572
Pubmed	Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation.	BMP4 SNAI1	1.29e-03	24	77	2	23552073
Pubmed	CPEB2-eEF2 interaction impedes HIF-1α RNA translation.	CPEB3 GAA	1.29e-03	24	77	2	22157746
Pubmed	Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism.	BMP4 SNAI1	1.29e-03	24	77	2	32521258
Pubmed	Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.	ABL1 FASLG	1.29e-03	24	77	2	27709293
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	TREH CPS1	1.29e-03	24	77	2	24625756
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	GLT8D2 GAA	1.40e-03	25	77	2	2283726
Pubmed	Patterning the dorsal telencephalon: a role for sonic hedgehog?	BMP4 RELN	1.40e-03	25	77	2	17959802
Pubmed	GATA6 is essential for embryonic development of the liver but dispensable for early heart formation.	BMP4 ABL1	1.40e-03	25	77	2	15767668
Pubmed	FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.	RELN KLB	1.40e-03	25	77	2	18625063
Pubmed	The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development.	BMP4 RELN	1.40e-03	25	77	2	22479201
Pubmed	Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development.	BMP4 SNAI1	1.40e-03	25	77	2	23560082
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	ABL1 NFRKB ISX PKN1 ALK	1.43e-03	372	77	5	22939624
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	GLT8D2 GAA	1.52e-03	26	77	2	8218172
Pubmed	Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription.	ABL1 POLG2	1.52e-03	26	77	2	24140708
Pubmed	Endothelial cells regulate neural crest and second heart field morphogenesis.	BMP4 SNAI1	1.52e-03	26	77	2	24996922
Pubmed	GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea.	BMP4 RPSA	1.64e-03	27	77	2	23666531
Pubmed	Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse.	BMP4 SNAI1	1.64e-03	27	77	2	31308417
Pubmed	Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.	BMP4 SNAI1	1.64e-03	27	77	2	23824573
Pubmed	An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.	BMP4 SNAI1	1.64e-03	27	77	2	27144312
Pubmed	Lamination of the cerebral cortex is disturbed in Gli3 mutant mice.	BMP4 RELN	1.64e-03	27	77	2	18448089
Pubmed	TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling.	BMP4 SNAI1	1.76e-03	28	77	2	27760115
Pubmed	Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.	CTTNBP2 SKIDA1	1.76e-03	28	77	2	33953184
Pubmed	The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.	BMP4 SNAI1	1.76e-03	28	77	2	28839193
Pubmed	Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells.	BMP4 RELN	1.76e-03	28	77	2	27178193
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	PTPRO TREH HPX TSPO ACY1 ALDH9A1 ALK GAA	1.83e-03	1016	77	8	19056867
Pubmed	EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.	BMP4 SNAI1	1.89e-03	29	77	2	18794329
Pubmed	Impaired Interneuron Development after Foxg1 Disruption.	RELN ROBO1	1.89e-03	29	77	2	26620267
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	PIK3C2B CEP85L FASLG	1.95e-03	111	77	3	22558309
Pubmed	Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids.	HEXA ABL1	2.02e-03	30	77	2	1914521
Pubmed	Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain.	RELN ROBO1	2.02e-03	30	77	2	17470284
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	BMP4 SNAI1	2.02e-03	30	77	2	32882513
Pubmed	HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development.	BMP4 SNAI1	2.02e-03	30	77	2	28538179
Pubmed	Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.	RELN ASPM	2.02e-03	30	77	2	19054571
Pubmed	Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.	BMP4 ROBO1	2.16e-03	31	77	2	22282597
GeneFamily	Fibronectin type III domain containing	PTPRO ROBO1 OSMR USH2A	4.64e-04	160	41	4	555
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ROBO1 PKD1L2 CPS1 USH2A SSPOP	7.43e-07	184	76	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ROBO1 PKD1L2 CPS1 USH2A SSPOP	7.43e-07	184	76	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN ROBO1 PKD1L2 CPS1 USH2A SSPOP	7.43e-07	184	76	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRD1 SPAM1 FASLG SSPOP FMO6P	4.20e-06	140	76	5	7ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRD1 SPAM1 FASLG SSPOP FMO6P	4.20e-06	140	76	5	1a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RELN MAGEL2 PTPRO ALK GAA	9.91e-06	167	76	5	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGEF10 CEP85L ANO7 CPS1 PDZD2	1.85e-05	190	76	5	d0297d678498e346e56cf95fe9e3db7d3ad3b837
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HEXA SIGLEC7 TSPO TWF2 GAA	2.14e-05	196	76	5	173d2c38a01c9ae1c50657d5fc383238aed4aacb
ToppCell	mLN-B_cell-Follicular_B_cell\|B_cell / Region, Cell class and subclass	TAPT1 ERV3-1 TSPO RPSA FAM111B	2.36e-05	200	76	5	8fbd27ffcfd0702ad3c340d32455e36a01617139
Drug	heptitol	TREH HPX GAA	4.22e-06	10	76	3	CID000101748
Drug	Bendroflumethiazide [73-48-3]; Up 200; 9.4uM; MCF7; HT_HG-U133A	DRD1 SPAM1 STS CPEB3 CPS1 ALK BDKRB2	4.76e-06	200	76	7	3840_UP
Drug	periodic acid	HEXA SPAM1 GALC SNAI1 ACY1 IDUA GP5	5.60e-06	205	76	7	CID000065185
Drug	4-methylumbelliferyl	HEXA GALC STS IDUA GAA	8.59e-06	83	76	5	CID000011833
Drug	valiolamine	HEXA TREH GAA	9.98e-06	13	76	3	CID000174312
Drug	Sialic acids	HEXA SPAM1 STS SIGLEC7 COG1 HPX SNAI1 GP5	1.40e-05	329	76	8	CID000349960
Drug	1-deoxynojirimycin hydrochloride	HEXA GALC TREH ACY1 GAA	2.35e-05	102	76	5	CID000001374
Drug	AMPT	DRD1 TREH SNAI1	2.81e-05	18	76	3	CID000002112
Drug	trimethylantimony dichloride	DAND5 TSPO	3.29e-05	3	76	2	CID000097653
Drug	CD 86022	HEXA IDUA GAA	3.33e-05	19	76	3	CID000122617
Drug	SR121463	AVPR2 SNAI1 UCN2	3.33e-05	19	76	3	CID000158348
Drug	type-IV	HEXA SPAM1 SIGLEC7 COG1 HPX SNAI1 GP5	4.28e-05	281	76	7	CID000000906
Drug	Phenethicillin potassium salt [132-93-4]; Up 200; 10uM; HL60; HT_HG-U133A	GALC STS SIGLEC7 SNAI1 CPS1 GP5	5.59e-05	200	76	6	2542_UP
Drug	ginsenoside	HEXA TREH GAA	6.03e-05	23	76	3	CID000092797
Drug	NSC145118	CTTNBP2 ACY1	6.57e-05	4	76	2	CID000422576
Drug	trimethylantimony	DAND5 TSPO	6.57e-05	4	76	2	CID000011656
Drug	triethylenephosphoramide	DRD1 SNAI1 ALDH9A1 FASLG	6.65e-05	65	76	4	CID000011016
Drug	chondroitin sulfate	HEXA BMP4 SPAM1 GALC STS COG1 HPX IDUA	7.04e-05	413	76	8	CID000024766
Disease	glycine measurement, amino acid measurement	PKD1L2 CPS1	3.81e-05	4	75	2	EFO_0005134, EFO_0009767
Disease	Parkinson's disease (biomarker_via_orthology)	DRD1 ABL1 FASLG	6.09e-05	30	75	3	DOID:14330 (biomarker_via_orthology)
Disease	ureteral obstruction (biomarker_via_orthology)	DRD1 ABL1 AVPR2	2.07e-04	45	75	3	DOID:5199 (biomarker_via_orthology)
Disease	Papillary Renal Cell Carcinoma	PIDD1 ACY1 ALK FAM111B	3.24e-04	128	75	4	C1306837
Disease	Renal Cell Carcinoma	PIDD1 ACY1 ALK FAM111B	3.24e-04	128	75	4	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	PIDD1 ACY1 ALK FAM111B	3.24e-04	128	75	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	PIDD1 ACY1 ALK FAM111B	3.24e-04	128	75	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	PIDD1 ACY1 ALK FAM111B	3.24e-04	128	75	4	C1266044
Disease	Cardiomyopathies	AVPR2 FASLG BDKRB2 GAA	3.43e-04	130	75	4	C0878544
Disease	pyroglutamine measurement	RELN ABL1 CPS1	4.40e-04	58	75	3	EFO_0005408
Disease	cortical thickness	BMP4 DAND5 RELN CTTNBP2 ROBO1 RPSA USP35 OSMR IDUA PDZD2	5.02e-04	1113	75	10	EFO_0004840
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	PIDD1 ACY1 ALK FAM111B	5.60e-04	148	75	4	C0279702
Disease	cortical surface area measurement	DAND5 RELN CTTNBP2 TREH SKIDA1 ROBO1 RPSA USP35 CPS1 IDUA PDZD2	5.68e-04	1345	75	11	EFO_0010736
Disease	Cardiomyopathies, Primary	AVPR2 FASLG BDKRB2	7.33e-04	69	75	3	C0033141
Disease	Myocardial Diseases, Secondary	AVPR2 FASLG BDKRB2	7.33e-04	69	75	3	C0036529
Disease	ureidopropionic acid measurement	ZNF704 CPS1	7.48e-04	16	75	2	EFO_0010542
Disease	Rheumatoid Arthritis	BMP4 STS FASLG BDKRB2	1.02e-03	174	75	4	C0003873
Disease	chronic myeloid leukemia (is_implicated_in)	ABL1 FASLG	1.30e-03	21	75	2	DOID:8552 (is_implicated_in)
Disease	gastric ulcer (biomarker_via_orthology)	IDUA FASLG	1.30e-03	21	75	2	DOID:10808 (biomarker_via_orthology)
Disease	Autism Spectrum Disorders	RELN CTTNBP2 USH2A	1.34e-03	85	75	3	C1510586
Disease	seminoma (is_marker_for)	CHEK2 FASLG	1.42e-03	22	75	2	DOID:4440 (is_marker_for)
Disease	neuroimaging measurement	DAND5 RELN CTTNBP2 PROSER3 SKIDA1 ROBO1 RPSA IDUA SH2D5	1.53e-03	1069	75	9	EFO_0004346
Disease	Malignant neoplasm of breast	BMP4 ABL1 AVPR2 CEP85L CHEK2 ROBO1 SNAI1 ACY1 ALK	1.58e-03	1074	75	9	C0006142
Disease	aspartate measurement	TSPO CPS1	1.70e-03	24	75	2	EFO_0010462
Disease	optic disc size measurement	BMP4 ARHGEF10 CHEK2 PDZD2	1.87e-03	205	75	4	EFO_0004832

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETWNPEKAASWNQAP	SYT13	146	Q7L8C5
NWFWEGDDTSFDPNP	BHLHB9	176	Q6PI77
EAPNTWQAPSGLYWI	ERV3-1	406	Q14264
PFWAITISNNFDWLF	BDKRB2	111	P30411
WNYPFQIASWKSAPA	ALDH9A1	156	P49189
SALARWAADPANTAW	ARHGEF10	216	O15013
WAADPANTAWMENPE	ARHGEF10	221	O15013
FVWFGWANSSLNPII	DRD1	316	P21728
APWARLWALQDGFAN	CHEK2	91	O96017
DFSDVGWNDWIVAPP	BMP4	316	P12644
QGFTWWLNFILTPDD	ASPM	701	Q8IZT6
PSAQDQLASAWFPAW	ISX	186	Q2M1V0
AKFPEPNFWSNWSSW	OSMR	121	Q99650
PNQASNWSAGLLAWL	ANO7	196	Q6IWH7
PQSWAAANQTWALGP	DAND5	31	Q8N907
LQASLAAWQAPQPAW	MAGEL2	51	Q9UJ55
TAPLNQWVSEAGPLW	GIGYF1	811	O75420
WFSAAPNWAELVLPA	NFRKB	416	Q6P4R8
KWDNWPPESDRNFFL	INTS1	626	Q8N201
NLQISDPWDPRWASG	ERVFC1-1	181	P60608
WVWEAGLSPNANPAA	CFAP65	961	Q6ZU64
NAWRDAFWPSQILAG	FER1L4	1361	A9Z1Z3
FNDSSSEINWAPILW	KCNT1	136	Q5JUK3
AWAAGAPAYPQWASQ	PDZD2	1486	O15018
PGNWAFKDQVAALSW	CES5A	191	Q6NT32
WFTPPRTSNQWLDFW	POLG2	241	Q9UHN1
VHNDLWESWFVPDPA	GLT8D2	326	Q9H1C3
GAAIPTADLQAWWAA	FMO6P	376	O60774
AATYWLAAALAWAAP	MFSD3	171	Q96ES6
SWGAPISWEQADPFA	MFSD14A	221	Q96MC6
QDAKTPATAFRWWQP	RELN	1566	P78509
PWSWQGSSLRPDAAD	PKD1L2	1076	Q7Z442
QPYWWDSASAAPESE	PTPRO	296	Q16827
LWPATQENPSARWSA	PIK3C2B	756	O00750
DWLNANNVPATPVAW	CPS1	1396	P31327
WSESPNDLPSDAAWV	COG1	476	Q8WTW3
LPTPSNISAWWNFGS	MT-CYB	21	P00156
QSVNAAWSAPSNPWG	CPEB3	246	Q8NE35
PWSVGQSFAQSPWDF	CTTNBP2	1061	Q8WZ74
GLTNSDAWEAWYNLP	C19orf71	66	A6NCJ1
DAWEAWYNLPRAPAS	C19orf71	71	A6NCJ1
AWFPSESSWQLPQLP	LINC02875	151	Q86X59
WQWNPSDRPSFAEIH	ABL1	476	P00519
PDYSSAWLPANESLW	CEP85L	26	Q5SZL2
WSLPQPWRADVTYAA	IDUA	306	P35475
AFPDFTNPTALAWWE	GAA	486	P10253
LAPNSSEPWVWAQPV	GP5	496	P40197
WAEPANPYADSHWRA	KLB	746	Q86Z14
NVPFLWAWNAPSEFC	SPAM1	46	P38567
PDNWFSIEPWLKVSN	FAM111B	526	Q6SJ93
WTDIPVNFPKNGWAA	GALC	651	P54803
NNWNWDLGPFPNSPW	AUNIP	311	Q9H7T9
YWAPPAATWDDITAQ	PIDD1	556	Q9HB75
PQWPWAEEAAAALAN	HGH1	116	Q9BTY7
LWSNVSALEFWEAPA	MMP28	161	Q9H239
FAGRATALWPWPQNF	HEXA	16	P06865
WPQGPSAVDAAFSWE	HPX	301	P02790
DWSAQPATEDWSAAP	RPSA	266	P08865
NYNPSAIWEPLDWQS	USH2A	1681	O75445
FPRNWDDLDPAVWTF	SSPOP	2181	A2VEC9
WTPNPAFREAESWSQ	PRDM15	126	P57071
LSAREAFPAAWEAWP	SH2D5	261	Q6ZV89
SPAEWNLQSWAPKAS	SKIDA1	516	Q1XH10
WNDWQPRTDSASADP	nan	21	Q6P435
LPEVPDQFSWNNFLW	STS	541	P08842
DISWKAPVATNNPAW	SIGLEC7	71	Q9Y286
QPAGPTPADFWWLQS	PROSER3	121	Q2NL68
WWLQSDSPDPSSQSA	PROSER3	131	Q2NL68
SWKPCGPNAWDQSFT	PKN1	406	Q16512
YSPPLHDLRNQSWSW	ALK	276	Q9UM73
PTDDSNPWWAAFSRV	ACY1	316	Q03154
WDSVLAPQAQPIAWA	SNAI1	61	O95863
AAWSPFQRTSWVQPL	GGCX	491	P38435
WWNLAKQFASRSPPL	XPO4	726	Q9C0E2
SASWTPWFSPGTQQD	USP35	506	Q9P2H5
LQPWTPADWKDSPQF	TREH	101	O43280
QWDFPNAWAPLQDLV	TREH	461	O43280
NISEPAAQPWLADTW	ROBO1	966	Q9Y6N7
AAQPWLADTWPNTGN	ROBO1	971	Q9Y6N7
QIYWVDSSASSPWAP	FASLG	11	P48023
WSWSAPSDQSNPSTP	ZNF704	131	Q6ZNC4
ESPSAAPTWPWAAQS	UCN2	46	Q96RP3
EQFSWNPDHLWVLFP	TAPT1	326	Q6NXT6
QNAQGFEWLFLAWSP	TWF2	76	Q6IBS0
FEWLFLAWSPDNSPV	TWF2	81	Q6IBS0
TGQLALNWAWPPIFF	TSPO	86	P30536
PFFLVQLWAAWDPEA	AVPR2	286	P30518