Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptidyltransferase activity	GGT2P GGT1	3.32e-04	6	95	2	GO:0000048
GeneOntologyMolecularFunction	leukotriene-C(4) hydrolase	GGT2P GGT1	3.32e-04	6	95	2	GO:0002951
GeneOntologyMolecularFunction	leukotriene C4 gamma-glutamyl transferase activity	GGT2P GGT1	6.16e-04	8	95	2	GO:0103068
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	GAPVD1 ARHGAP40 CYTH3 CYTH2 TBC1D25 ARHGEF10L NPRL2 DENND2C DOCK6	6.94e-04	507	95	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	GAPVD1 ARHGAP40 CYTH3 CYTH2 TBC1D25 ARHGEF10L NPRL2 DENND2C DOCK6	6.94e-04	507	95	9	GO:0030695
GeneOntologyMolecularFunction	glutathione hydrolase activity	GGT2P GGT1	7.89e-04	9	95	2	GO:0036374
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	GAPVD1 CYTH3 CYTH2 ARHGEF10L DENND2C DOCK6	8.28e-04	231	95	6	GO:0005085
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	9.83e-04	10	95	2	GO:0001849
GeneOntologyMolecularFunction	enzyme regulator activity	PDC GAPVD1 ARHGAP40 CYTH3 CYTH2 RPS6KA3 BIRC2 TBC1D25 ARHGEF10L PARP6 NPRL2 DENND2C C4A C4B DOCK6 NOS1AP	1.01e-03	1418	95	16	GO:0030234
GeneOntologyCellularComponent	cell body	RELN NTRK1 GRIA1 SLC12A2 NF2 MTOR KCNJ4 VPS35 ENTPD2 C4A C4B CACNA1G ATP1A3 HTT	1.07e-04	929	98	14	GO:0044297
HumanPheno	Heterotopias/abnormal migration	RELN RPS6KA3 TOGARAM1 TSEN54 FLVCR2 GGT1 NPRL2 TMTC3 MTOR SMARCD1 CDK5RAP2 ATP1A3 CPLANE1 DOCK6 MED12	9.94e-06	477	46	15	HP:0007317
HumanPheno	Abnormality of neuronal migration	RELN RPS6KA3 TOGARAM1 TSEN54 FLVCR2 GGT1 NPRL2 TMTC3 MTOR SMARCD1 CDK5RAP2 ATP1A3 CPLANE1 DOCK6 MED12	9.94e-06	477	46	15	HP:0002269
Domain	SWIB_MDM2_domain	EIF2D SMARCD1 SMARCD2	2.44e-06	6	94	3	IPR003121
Domain	-	EIF2D SMARCD1 SMARCD2	2.44e-06	6	94	3	1.10.245.10
Domain	HEAT	TNPO1 TOGARAM1 PIK3R4 MTOR HTT	1.08e-05	58	94	5	IPR000357
Domain	HEAT_REPEAT	TNPO1 TOGARAM1 PIK3R4 MTOR HTT	2.71e-05	70	94	5	PS50077
Domain	SWIB_domain	SMARCD1 SMARCD2	7.49e-05	3	94	2	IPR019835
Domain	SWIB	SMARCD1 SMARCD2	7.49e-05	3	94	2	SM00151
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.48e-04	5	94	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.48e-04	5	94	2	IPR001840
Domain	SWIB	SMARCD1 SMARCD2	2.48e-04	5	94	2	PF02201
Domain	ZnF_U1	TUT7 ZFHX4 ZNF638	4.10e-04	29	94	3	SM00451
Domain	Znf_U1	TUT7 ZFHX4 ZNF638	4.10e-04	29	94	3	IPR003604
Domain	ANATO	C4A C4B	5.18e-04	7	94	2	SM00104
Domain	ANATO	C4A C4B	5.18e-04	7	94	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	5.18e-04	7	94	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	5.18e-04	7	94	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	5.18e-04	7	94	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	6.88e-04	8	94	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	6.88e-04	8	94	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	6.88e-04	8	94	2	IPR019742
Domain	-	TNPO1 TOGARAM1 PIK3R4 MTOR MED12 HTT	8.99e-04	222	94	6	1.25.10.10
Domain	A2M_N	C4A C4B	1.10e-03	10	94	2	PF01835
Domain	A2M_N	C4A C4B	1.10e-03	10	94	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.10e-03	10	94	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.10e-03	10	94	2	PS00477
Domain	A2M	C4A C4B	1.10e-03	10	94	2	PF00207
Domain	A2M_N_2	C4A C4B	1.10e-03	10	94	2	IPR011625
Domain	A2M_comp	C4A C4B	1.10e-03	10	94	2	IPR011626
Domain	A2M_N_2	C4A C4B	1.10e-03	10	94	2	PF07703
Domain	A2M_recep	C4A C4B	1.10e-03	10	94	2	PF07677
Domain	A2M_comp	C4A C4B	1.10e-03	10	94	2	PF07678
Domain	Macroglobln_a2	C4A C4B	1.10e-03	10	94	2	IPR001599
Domain	ARM-type_fold	TNPO1 TOGARAM1 PIK3R4 URB1 MTOR VPS35 HTT	1.62e-03	339	94	7	IPR016024
Domain	HEAT	TNPO1 PIK3R4 HTT	1.81e-03	48	94	3	PF02985
Domain	Cadherin_CS	PCDHA11 PCDHA10 CDH15 CDHR4	2.24e-03	109	94	4	IPR020894
Domain	ARM-like	TNPO1 TOGARAM1 PIK3R4 MTOR MED12 HTT	2.43e-03	270	94	6	IPR011989
Domain	-	CYTH3 CYTH2	2.52e-03	15	94	2	1.10.1000.11
Domain	Sec7	CYTH3 CYTH2	2.52e-03	15	94	2	PF01369
Domain	Sec7_alpha_orthog	CYTH3 CYTH2	2.52e-03	15	94	2	IPR023394
Domain	CADHERIN_1	PCDHA11 PCDHA10 CDH15 CDHR4	2.55e-03	113	94	4	PS00232
Domain	Cadherin	PCDHA11 PCDHA10 CDH15 CDHR4	2.55e-03	113	94	4	PF00028
Domain	CADHERIN_2	PCDHA11 PCDHA10 CDH15 CDHR4	2.63e-03	114	94	4	PS50268
Domain	-	PCDHA11 PCDHA10 CDH15 CDHR4	2.63e-03	114	94	4	2.60.40.60
Domain	CA	PCDHA11 PCDHA10 CDH15 CDHR4	2.72e-03	115	94	4	SM00112
Domain	Cadherin-like	PCDHA11 PCDHA10 CDH15 CDHR4	2.80e-03	116	94	4	IPR015919
Domain	AGC-kinase_C	RPS6KA3 GRK5 PRKACB	2.82e-03	56	94	3	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA3 GRK5 PRKACB	2.82e-03	56	94	3	PS51285
Domain	S_TK_X	RPS6KA3 GRK5 PRKACB	2.82e-03	56	94	3	SM00133
Domain	Sec7	CYTH3 CYTH2	2.87e-03	16	94	2	SM00222
Domain	SEC7	CYTH3 CYTH2	2.87e-03	16	94	2	PS50190
Domain	Sec7_dom	CYTH3 CYTH2	2.87e-03	16	94	2	IPR000904
Domain	Cadherin	PCDHA11 PCDHA10 CDH15 CDHR4	2.98e-03	118	94	4	IPR002126
Domain	C345C	C4A C4B	3.24e-03	17	94	2	SM00643
Domain	-	CYTH3 CYTH2 PLEKHN1 ARHGEF10L NF2 MTMR3 NOS1AP	3.59e-03	391	94	7	2.30.29.30
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	3.64e-03	18	94	2	IPR008930
Domain	NTR	C4A C4B	4.05e-03	19	94	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	4.05e-03	19	94	2	IPR018933
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 SEMA3F CYTH3 GRK5 TBC1D25 TMEM127 ARHGEF10L URB1 NF2 MTOR PCNX4 ENTPD2 MTMR3 DOCK6 MED12 HTT	7.97e-08	1105	98	16	35748872
Pubmed	Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.	PIK3R4 MTOR HTT	3.52e-06	11	98	3	32093570
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	7.86e-06	2	98	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	7.86e-06	2	98	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	7.86e-06	2	98	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	7.86e-06	2	98	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	7.86e-06	2	98	2	19933335
Pubmed	Gamma glutamyl transferase activity is independently associated with oxidative stress rather than SYNTAX score.	GGT2P GGT1	7.86e-06	2	98	2	25180444
Pubmed	Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg.	AMHR2 MED12	7.86e-06	2	98	2	29126187
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	7.86e-06	2	98	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	7.86e-06	2	98	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	7.86e-06	2	98	2	12207352
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	7.86e-06	2	98	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	7.86e-06	2	98	2	22387014
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	7.86e-06	2	98	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	7.86e-06	2	98	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	7.86e-06	2	98	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	7.86e-06	2	98	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	7.86e-06	2	98	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	7.86e-06	2	98	2	6950384
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	7.86e-06	2	98	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	7.86e-06	2	98	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	7.86e-06	2	98	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	7.86e-06	2	98	2	21345967
Pubmed	NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway.	NPRL2 MTOR	7.86e-06	2	98	2	32234375
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	7.86e-06	2	98	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	7.86e-06	2	98	2	2302180
Pubmed	Association between serum γ-glutamyltranspeptidase and atherosclerosis: a population-based cross-sectional study.	GGT2P GGT1	7.86e-06	2	98	2	25280803
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	7.86e-06	2	98	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	7.86e-06	2	98	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	7.86e-06	2	98	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	7.86e-06	2	98	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	7.86e-06	2	98	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	7.86e-06	2	98	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	7.86e-06	2	98	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	7.86e-06	2	98	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	7.86e-06	2	98	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	7.86e-06	2	98	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	7.86e-06	2	98	2	2387317
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	7.86e-06	2	98	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	7.86e-06	2	98	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	7.86e-06	2	98	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	7.86e-06	2	98	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	7.86e-06	2	98	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	7.86e-06	2	98	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	7.86e-06	2	98	2	6881182
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	7.86e-06	2	98	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	7.86e-06	2	98	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	7.86e-06	2	98	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	7.86e-06	2	98	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	7.86e-06	2	98	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	7.86e-06	2	98	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	7.86e-06	2	98	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	7.86e-06	2	98	2	3794341
Pubmed	HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.	HDAC4 HTT	7.86e-06	2	98	2	24302884
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	7.86e-06	2	98	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	7.86e-06	2	98	2	32691186
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	7.86e-06	2	98	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	7.86e-06	2	98	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	7.86e-06	2	98	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	7.86e-06	2	98	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	7.86e-06	2	98	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	7.86e-06	2	98	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	7.86e-06	2	98	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	7.86e-06	2	98	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	7.86e-06	2	98	2	6559257
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	7.86e-06	2	98	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	7.86e-06	2	98	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	7.86e-06	2	98	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	7.86e-06	2	98	2	26800705
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	7.86e-06	2	98	2	15390104
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	7.86e-06	2	98	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	7.86e-06	2	98	2	2997024
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	7.86e-06	2	98	2	3624865
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	7.86e-06	2	98	2	21857912
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	7.86e-06	2	98	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	7.86e-06	2	98	2	4514997
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	7.86e-06	2	98	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	7.86e-06	2	98	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	7.86e-06	2	98	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	7.86e-06	2	98	2	30041577
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	7.86e-06	2	98	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	7.86e-06	2	98	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	7.86e-06	2	98	2	18360261
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	7.86e-06	2	98	2	26814963
Pubmed	Clinical application value of hepatitis B virus basal core promoter 1762/1764 and GGTII and GGT in patients with HBV-DNA-positive primary liver cancer.	GGT2P GGT1	7.86e-06	2	98	2	37904480
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	7.86e-06	2	98	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	7.86e-06	2	98	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	7.86e-06	2	98	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	7.86e-06	2	98	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	7.86e-06	2	98	2	6167582
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	7.86e-06	2	98	2	1438267
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	7.86e-06	2	98	2	19150565
Pubmed	Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling.	GGT2P GGT1	7.86e-06	2	98	2	23682772
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	7.86e-06	2	98	2	17506029
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	7.86e-06	2	98	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	7.86e-06	2	98	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	7.86e-06	2	98	2	2993295
Pubmed	Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.	CYTH3 CYTH2	7.86e-06	2	98	2	31601460
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	7.86e-06	2	98	2	3944109
Interaction	YWHAH interactions	NSUN4 GAPVD1 HDAC4 NTRK1 CYTH2 RPS6KA3 TBC1D25 PIK3R4 SLC12A2 ALMS1 MTOR SHCBP1 DENND2C MTMR3 ZNF638 DOCK6 HTT NOS1AP	4.59e-06	1102	97	18	int:YWHAH
Cytoband	Ensembl 112 genes in cytogenetic band chr16q11	SHCBP1 VPS35	2.94e-04	12	98	2	chr16q11
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	3.00e-04	9	53	2	1234
GeneFamily	CD molecules\|Gamma-glutamyltransferases	GGT2P GGT1	6.44e-04	13	53	2	564
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	INPP1 GGT1 PARP6 URB1 SHCBP1 MED12	2.33e-06	173	98	6	090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	INPP1 GGT1 PARP6 URB1 SHCBP1 MED12	2.41e-06	174	98	6	a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell	droplet-Lung-nan-21m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMHR2 ARHGAP40 TMPRSS6 PRR15L GGT1 CDH15	3.32e-06	184	98	6	7cc3b9bba1f600b40b02fe2456b5d007dbf9fa37
ToppCell	droplet-Lung-nan-21m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMHR2 ARHGAP40 TMPRSS6 PRR15L GGT1 CDH15	3.32e-06	184	98	6	53b71c4ac86dc5e42763b8f64fbc917177531017
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ZFHX4 ENTPD2 SLIT3 C4B	4.00e-06	190	98	6	dc7e92f1b18d0f5efec11d09d56ba954d4f8b3bd
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ZFHX4 ENTPD2 SLIT3 C4B	4.00e-06	190	98	6	0bb06df3d5a50416854370f234718c6cec3d773b
ToppCell	facs-SCAT-Fat-24m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ZFHX4 ENTPD2 SLIT3 C4B	4.00e-06	190	98	6	008290bb5c79446681dd6bf354336c57ad0d6f13
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE ALMS1 ZFHX4 ENTPD2 ATP1A3	4.38e-05	176	98	5	c0a084f7a8645262d61971f094689e02bf15b113
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACE ALMS1 ZFHX4 ENTPD2 ATP1A3	4.38e-05	176	98	5	cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMHR2 TMPRSS6 PRR15L SLC12A2 HABP2	4.50e-05	177	98	5	2af09028014f4ec3b7d2a4c286f1ae5e84a9f590
ToppCell	AT1_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	TMPRSS6 GRK5 GGT1 LRRC1 TACSTD2	4.87e-05	180	98	5	e1964002681f80d8d62406b6ee52a01e1829ccf2
ToppCell	15-Airway-Epithelial-Submucosal_gland\|Airway / Age, Tissue, Lineage and Cell class	PRR15L SLC12A2 LRRC1 TACSTD2 NOS1AP	4.87e-05	180	98	5	283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP40 TMPRSS6 KCNJ4 SLIT3 PDE7B	5.13e-05	182	98	5	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP40 TMPRSS6 KCNJ4 SLIT3 PDE7B	5.13e-05	182	98	5	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-club_cell-club_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AMHR2 ARHGAP40 TMPRSS6 PRR15L CDH15	5.41e-05	184	98	5	204d16c48f822c98dc4118ac97a4f99f7e1163c8
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial-club_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AMHR2 ARHGAP40 TMPRSS6 PRR15L CDH15	5.41e-05	184	98	5	9365cdc52a2419e3f27e1c1c9310fa707d1e506b
ToppCell	IPF-Myeloid-Mast\|IPF / Disease state, Lineage and Cell class	AMHR2 CYTH3 NTRK1 TSEN54 PDE7B	5.41e-05	184	98	5	c3baf21f10b45cf91ac99997a59f353bcf3de8b7
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	CYTH3 GRK5 SLC12A2 DOCK6 PDE7B	5.55e-05	185	98	5	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	facs-Heart-LA-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	5.69e-05	186	98	5	ed0a91f47e77fe21d4c7678d0f2a7c5f97d63dda
ToppCell	facs-Trachea-nan-24m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	5.84e-05	187	98	5	71385068e3fd0bfa7822ae176113a49460c8636b
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	5.84e-05	187	98	5	f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCell	facs-SCAT-Fat-3m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP40 PRR15L GGT1 SLC12A2 TACSTD2	5.84e-05	187	98	5	08f2ecce3c08f35d995187b21bb7407a99dee4c2
ToppCell	facs-SCAT-Fat-3m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP40 PRR15L GGT1 SLC12A2 TACSTD2	5.84e-05	187	98	5	939a068ac0913b9eeb5da4a9cb267d51cb711999
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	5.84e-05	187	98	5	1669df899b1759c338ffce196fe009840123cfcd
ToppCell	facs-Trachea-nan-24m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	5.84e-05	187	98	5	b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCell	facs-Trachea-nan-24m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	5.84e-05	187	98	5	e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCell	facs-SCAT-Fat-3m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP40 PRR15L GGT1 SLC12A2 TACSTD2	5.84e-05	187	98	5	e02e7f608506b9a48384f07727944f1cb8f7c575
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 NTRK1 TMPRSS6 ENTPD2 SLIT3	6.14e-05	189	98	5	f0a2d4ef9896d764971ebbc6952510c128bb76e8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC4 ARHGEF10L SHCBP1 PDE7B NOS1AP	6.14e-05	189	98	5	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 NTRK1 TMPRSS6 ENTPD2 SLIT3	6.14e-05	189	98	5	378f26f751ab4b470948c35dd8347de72dd12ff7
ToppCell	facs-GAT-Fat-24m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	6.30e-05	190	98	5	3720e64129f3f3268b1dc14031a76f41c38241c2
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	6.30e-05	190	98	5	73a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCell	facs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	6.30e-05	190	98	5	b55cf1fb586b724295b7b038483249847bb344fc
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NTRK1 TMPRSS6 ENTPD2 SLIT3 C4B	6.45e-05	191	98	5	2b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 CHD1 ZFHX4 ENTPD2 CDH15	6.45e-05	191	98	5	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC4 ARHGEF10L SHCBP1 PDE7B NOS1AP	6.61e-05	192	98	5	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 CHD1 ZFHX4 ENTPD2 SLIT3	6.61e-05	192	98	5	11088878043a6ff95ba1970361256a82e434b80a
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	6.61e-05	192	98	5	2d9e2262f1342fe17735f21f733c029d1275e955
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HDAC4 ARHGEF10L SHCBP1 PDE7B NOS1AP	6.61e-05	192	98	5	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 GRIA1 KCNJ4 ATP1A3 NOS1AP	6.78e-05	193	98	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ZFHX4 ENTPD2 SLIT3 C4B	6.78e-05	193	98	5	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ZFHX4 ENTPD2 SLIT3 C4B	6.78e-05	193	98	5	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	6.78e-05	193	98	5	49600db68ed65cafc67bd45a285b364e4f5f88af
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 GRIA1 KCNJ4 ATP1A3 NOS1AP	6.78e-05	193	98	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 GRIA1 KCNJ4 ATP1A3 NOS1AP	6.78e-05	193	98	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ZFHX4 ENTPD2 SLIT3 C4B	6.78e-05	193	98	5	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RELN CACNA1G ATP1A3 CDH15	6.78e-05	193	98	5	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS6 ACE ENTPD2 SLIT3 C4B	6.78e-05	193	98	5	45b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PCDHA10 ENTPD2 C4A C4B PDE7B	7.65e-05	198	98	5	7a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SEMA3F INPP1 ACE SLC12A2 DOCK6	7.83e-05	199	98	5	14a7c4cf4bb3d43fd32ec9cc74f6625b225ffaa1
Disease	Schizophrenia	RELN HDAC4 NTRK1 GRIA1 ACE NPRL2 SLC12A2 MTOR VPS35 SLIT3 PDE7B MED12 NOS1AP	6.48e-06	883	97	13	C0036341
Disease	Etat Marbre	TSEN54 SLC12A2 HTT	5.81e-05	23	97	3	C0266487
Disease	Movement Disorders	TSEN54 SLC12A2 HTT	1.18e-04	29	97	3	C0026650
Disease	liver cirrhosis (is_marker_for)	RELN ACE GGT1 ENTPD2	1.58e-04	82	97	4	DOID:5082 (is_marker_for)
Disease	Mental Depression	RELN HDAC4 GRIA1 ATP1A3 MED12 HTT	1.97e-04	254	97	6	C0011570
Disease	aflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)	GGT2P GGT1	2.22e-04	7	97	2	DOID:5022 (biomarker_via_orthology)
Disease	Cardiovascular Diseases	GRK5 ACE SLC12A2	2.27e-04	36	97	3	C0007222
Disease	calcium measurement	TNPO1 HDAC4 GRK5 GGT1 SLC12A2 PCNX4 EXOC3L2 ATP1A3 PDE7B	2.29e-04	628	97	9	EFO_0004838
Disease	Graves' disease (is_implicated_in)	TSHR C4A C4B	2.89e-04	39	97	3	DOID:12361 (is_implicated_in)
Disease	alcohol dependence (biomarker_via_orthology)	GGT2P GGT1	2.96e-04	8	97	2	DOID:0050741 (biomarker_via_orthology)
Disease	mitral valve prolapse (is_implicated_in)	TSHR ACE	3.79e-04	9	97	2	DOID:988 (is_implicated_in)
Disease	Coffin-Siris syndrome (implicated_via_orthology)	SMARCD1 SMARCD2	3.79e-04	9	97	2	DOID:1925 (implicated_via_orthology)
Disease	Depressive disorder	RELN GRIA1 ACE ATP1A3 MED12 HTT	3.93e-04	289	97	6	C0011581
Disease	middle cerebral artery infarction (implicated_via_orthology)	ACE SLC12A2 MTOR	4.42e-04	45	97	3	DOID:3525 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	GRK5 PRKACB SMARCD1 SMARCD2 ATP1A3	4.72e-04	195	97	5	DOID:1574 (implicated_via_orthology)
Disease	2-ketocaprylate measurement	ALMS1 PCNX4	4.73e-04	10	97	2	EFO_0800110
Disease	iron biomarker measurement, serum iron measurement	TMPRSS6 TFR2	6.91e-04	12	97	2	EFO_0004461, EFO_0006332
Disease	Intellectual Disability	HDAC4 GRIA1 TSEN54 MTOR SMARCD1 CACNA1G HTT	6.95e-04	447	97	7	C3714756
Disease	Malignant neoplasm of breast	CATSPERE HDAC4 TMPRSS6 RPS6KA3 BIRC2 PIK3R4 NF2 MTOR MTMR3 SMARCD1 MED12	8.06e-04	1074	97	11	C0006142
Disease	iron biomarker measurement, transferrin saturation measurement	TMPRSS6 TFR2	9.49e-04	14	97	2	EFO_0004461, EFO_0006333
Disease	transferrin saturation measurement	TMPRSS6 TFR2	1.25e-03	16	97	2	EFO_0006333
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	ACE MTOR	1.25e-03	16	97	2	DOID:0110861 (implicated_via_orthology)
Disease	Major Depressive Disorder	RELN ACE MTOR SLIT3 MED12	1.27e-03	243	97	5	C1269683
Disease	mean reticulocyte volume	TNPO1 CHD1 TFR2 TMTC3 MTOR ZNF638 EXOC3L2 CDH15 NOS1AP	1.28e-03	799	97	9	EFO_0010701
Disease	Huntington Disease	RELN HTT	1.41e-03	17	97	2	C0020179
Disease	obsolete_red blood cell distribution width	TNPO1 NTRK1 TMPRSS6 TUT7 FAM219B TFR2 NPRL2 SLC12A2 EXOC3L2 DOCK6 PDE7B CDH15	1.55e-03	1347	97	12	EFO_0005192
Disease	dentures	PRUNE2 MTMR3 MED12	1.61e-03	70	97	3	EFO_0010078
Disease	dental caries, dentures	PRUNE2 MTMR3 MED12	1.61e-03	70	97	3	EFO_0003819, EFO_0010078
Disease	Unipolar Depression	RELN ACE MTOR SLIT3 MED12	1.68e-03	259	97	5	C0041696
Disease	Autistic Disorder	RELN INPP1 GRIA1 ACE C4B	1.73e-03	261	97	5	C0004352
Disease	end stage renal disease (implicated_via_orthology)	ACE MTOR	1.96e-03	20	97	2	DOID:783 (implicated_via_orthology)
Disease	epilepsy (biomarker_via_orthology)	GRIA1 NF2	2.16e-03	21	97	2	DOID:1826 (biomarker_via_orthology)
Disease	Mood Disorders	RELN HDAC4 TBC1D25 HTT	2.33e-03	168	97	4	C0525045
Disease	nephrotic syndrome (implicated_via_orthology)	GAPVD1 ACE	2.82e-03	24	97	2	DOID:1184 (implicated_via_orthology)
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	ACE SLIT3	2.82e-03	24	97	2	DOID:3827 (biomarker_via_orthology)
Disease	antiphospholipid syndrome	GRK5 TSHR	2.82e-03	24	97	2	EFO_0002689
Disease	Left Ventricular Hypertrophy	ACE MTOR	3.05e-03	25	97	2	C0149721

Protein segments in the cluster

Peptide	Gene	Start	Entry
QDEPYQALVAELHRR	EXOC3L2	216	Q2M3D2
AHQPGAERNLLYEDA	ARHGEF10L	141	Q9HCE6
LEEYQLPRKHIQGLE	EIF2D	561	P41214
LDDGTIQIQDYPLHL	CATSPERE	556	Q5SY80
EGAIHREELVYELNP	C4B	936	P0C0L5
REELVYELNPLDHRG	C4B	941	P0C0L5
YELNPLDHRGRTLEI	C4B	946	P0C0L5
FEDDLEHLYQQLEPL	ACE	236	P12821
RQLLQDGYHLDEIPD	FAM219B	151	Q5XKK7
YQQALLDSHLPEEAL	ALMS1	821	Q8TCU4
NPEYLDIRHLERGLQ	BIVM	386	Q86UB2
HEGLELRDYQLNGLN	CHD1	476	O14646
EVHLLGPLDYEQQRL	CDHR4	496	A6H8M9
QAERALYELPGLQHD	AMHR2	241	Q16671
IEEDNLTYQHLLPES	CDK5RAP2	1336	Q96SN8
EGEYLPLDQRDLNVG	KCNJ4	231	P48050
LLENLDDHYPELAEE	C22orf15	96	Q8WYQ4
VYALQPLDHEELELL	PCDHA11	516	Q9Y5I1
LDLPQLVYHVENEGA	INPP1	346	P49441
HLPGAENLTELYIEN	NTRK1	61	P04629
EEELREHQALLDEPY	HDAC4	526	P56524
EHQALLDEPYLDRLP	HDAC4	531	P56524
EYVNLHNELRGDVIP	GLIPR1L2	56	Q4G1C9
TEEIEILLRYGQHPN	RPS6KA3	461	P51812
YPNQDGDILRDQVLH	GAPVD1	1331	Q14C86
PHLNLGDSIRRDYED	DDX60L	381	Q5H9U9
PAEDRASEVQLHLYG	ENTPD2	216	Q9Y5L3
DDEERYSIQAHPLLL	PCNX4	1131	Q63HM2
LNEYGLLPEREVHVL	PDC	221	P20941
QAPLHLLDEDYLGQA	PDE7B	91	Q9NP56
YPHRLLDNEDGENPQ	MED12	1326	Q93074
ERIHYIGQNEPELLV	HMOX2	136	P30519
LEELDLGNNEIYNLP	LRRC1	176	Q9BTT6
VRHDYILLPEDALTN	RELN	3001	P78509
VDALGLHIYDPENRL	NF2	236	P35240
ILHSYVPEEIRDGNQ	NSUN4	216	Q96CB9
VYALQPLDHEELELL	PCDHA10	516	Q9Y5I2
YNERDEIPHNDIALL	HABP2	401	Q14520
SDILNYIDHGDPQVR	HTT	751	P42858
RDLKPENLLIDHQGY	PRKACB	166	P22694
LIGPDQKEYHRELER	DOCK6	1991	Q96HP0
GIEYHEQPEELTNAL	CACNA1G	761	O43497
YLNELAEKRGQEHDP	CPLANE1	2911	Q9H799
QEEALRDRHGNLPYD	JMJD4	261	Q9H9V9
NEGGDLPEELLRNLY	CYTH2	221	Q99418
NEGGDLPEELLRNLY	CYTH3	226	O43739
RNPHYQTLERDLIEL	DENND2C	471	Q68D51
RENSADEHLIPQLGY	BRWD1	611	Q9NSI6
LVPNIEDRDELAYHI	FLVCR2	236	Q9UPI3
GEPQLELHTLDLRDY	LEFTY2	231	O00292
SIHETEDPNDNRYLL	ATP1A3	481	P13637
EEYGVGDLIHNRLPD	EFHB	521	Q8N7U6
GPVHYEDIRENEARQ	CCDC174	231	Q6PII3
KYNLVDDGHDLRIPL	NOS1AP	6	O75052
RPELQDALISIIDHY	GRIA1	126	P42261
DLKPENILLDDYGHI	GRK5	311	P34947
HGPQDDLRDNVLNYD	CDH15	641	P55291
EGAIHREELVYELNP	C4A	936	P0C0L4
REELVYELNPLDHRG	C4A	941	P0C0L4
YELNPLDHRGRTLEI	C4A	946	P0C0L4
EDLNNYRAELIEHPL	GGT2P	251	P36268
EDENLQVPFLELHGE	MTMR3	26	Q13615
LAENPNLFDDHEEGR	PRR15L	86	Q9BU68
AADLYRHPQLDADIE	PARP6	31	Q2NL67
TLADEEEDPLIYQHR	MTOR	1221	P42345
LEHGADRNIPDEYGN	POTED	226	Q86YR6
QYGLTLSDLDRHPEI	RPIA	141	P49247
YHELLENLQFSPGIE	SPACA7	96	Q96KW9
HYIPGTDILDLENQR	PLEKHN1	56	Q494U1
IDEDLLREPEHFLYG	PRUNE2	2361	Q8WUY3
YVLSLDLHDINREPL	SEMA3F	76	Q13275
EQGRQRLHPEEALYL	TSEN54	106	Q7Z6J9
TYLNHEGQLSRPEEL	TBC1D25	206	Q3MII6
VIELDKDLYGPDNHL	SMARCD1	241	Q96GM5
DTNLHDYLREAPEDI	GIMAP4	161	Q9NUV9
RPSEHALVDNDGLYD	TACSTD2	91	P09758
EDRVPSGLIVDYHNL	SHCBP1	236	Q8NEM2
DQSLLLLPEYHQRVE	SKIV2L	1046	Q15477
SYHELDERLENDPNI	NPRL2	361	Q8WTW4
LQGDLDDFLPLIHVY	URB1	1261	O60287
LVIELDKELYGPDNH	SMARCD2	256	Q92925
DEIQGRYPHLLEQLL	BIRC2	346	Q13490
ERDSVGQLQLYRHPD	ATF6B	561	Q99941
EYILPGIAHLAQDDA	PIK3R4	461	Q99570
REELGLIEQAYDNPH	PRPF8	861	Q6P2Q9
ELYLEGNHLTAVPRE	SLIT3	756	O75094
AGHPELSEAELQQLY	ZFHX4	1401	Q86UP3
YEVGGNINEHRLDPD	ARHGAP40	586	Q5TG30
NINEHRLDPDAYLLD	ARHGAP40	591	Q5TG30
YQESPHDAEDILLLL	SPEM2	16	Q0P670
DENQLYLIAHLPRLE	TBCE	266	Q15813
HLLRSEDPDQQYLIL	VPS35	496	Q96QK1
APVHADDLREGAQYL	SLC12A2	856	P55011
QEDTPDLLHEDRLQY	nan	66	Q1RN00
LDVLANVYRDELLPH	TNPO1	391	Q92973
EGSDHDYLPLVRLQE	VWA5B2	1051	Q8N398
ATLDYALEDPHQGQR	TSPYL6	11	Q8N831
IPQELHSRLLDQEDY	TOGARAM1	351	Q9Y4F4
LETLALAPHEEYIQR	TMTC3	796	Q6ZXV5
DDDFRRGHPQQDYLI	TUT7	21	Q5VYS8
DVNYEPDLDFHQGRL	TFR2	121	Q9UP52
LRHYPTEEEEQALEL	TMEM127	196	O75204
IYDRFVHLDNLPEDG	ZNF638	1006	Q14966
DYDVALLQLDHPVVR	TMPRSS6	666	Q8IU80
PLHQEYEENLGDSIV	TSHR	321	P16473
EDLNNYRAELIEHPL	GGT1	251	P19440