Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of ventricular cardiac muscle cell action potential

CACNA1C RYR2

5.28e-0512192GO:0098911
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

CACNA1C RYR2

5.28e-0512192GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

CACNA1C RYR2

5.28e-0512192GO:0086016
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

CACNA1C RYR2

8.38e-0515192GO:0086067
GeneOntologyBiologicalProcessatrial cardiac muscle cell to AV node cell communication

CACNA1C RYR2

1.36e-0419192GO:0086066
GeneOntologyBiologicalProcessatrial cardiac muscle cell to AV node cell signaling

CACNA1C RYR2

1.36e-0419192GO:0086026
GeneOntologyBiologicalProcessatrial cardiac muscle cell action potential

CACNA1C RYR2

1.36e-0419192GO:0086014
GeneOntologyBiologicalProcesspositive regulation of insulin secretion

CACNA1C NCOA6 IRS2

1.74e-04120193GO:0032024
GeneOntologyBiologicalProcesspositive regulation of protein transport

CACNA1C NCOA6 CEP131 IRS2

1.81e-04319194GO:0051222
GeneOntologyBiologicalProcessregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

CACNA1C RYR2

1.84e-0422192GO:0010881
GeneOntologyBiologicalProcesscell communication by electrical coupling involved in cardiac conduction

CACNA1C RYR2

2.58e-0426192GO:0086064
GeneOntologyBiologicalProcessregulation of cardiac muscle contraction by calcium ion signaling

CACNA1C RYR2

3.00e-0428192GO:0010882
GeneOntologyBiologicalProcesspositive regulation of transport

AHSG CACNA1C NCOA6 CEP131 IRS2 RYR2

3.07e-041081196GO:0051050
GeneOntologyBiologicalProcessregulation of cardiac muscle cell action potential

CACNA1C RYR2

3.44e-0430192GO:0098901
GeneOntologyBiologicalProcesspositive regulation of peptide hormone secretion

CACNA1C NCOA6 IRS2

3.83e-04157193GO:0090277
GeneOntologyBiologicalProcesspositive regulation of peptide secretion

CACNA1C NCOA6 IRS2

4.13e-04161193GO:0002793
GeneOntologyBiologicalProcessregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

CACNA1C RYR2

4.17e-0433192GO:0010880
GeneOntologyBiologicalProcesspositive regulation of establishment of protein localization

CACNA1C NCOA6 CEP131 IRS2

4.41e-04403194GO:1904951
GeneOntologyBiologicalProcesscell-cell signaling involved in cardiac conduction

CACNA1C RYR2

4.43e-0434192GO:0086019
GeneOntologyBiologicalProcesscell communication by electrical coupling

CACNA1C RYR2

4.70e-0435192GO:0010644
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

CACNA1C RYR2

5.25e-0437192GO:0014808
GeneOntologyBiologicalProcessventricular cardiac muscle cell action potential

CACNA1C RYR2

5.25e-0437192GO:0086005
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

CACNA1C RYR2

5.84e-0439192GO:1903514
GeneOntologyBiologicalProcesscalcium ion transport into cytosol

CACNA1C RYR2

6.77e-0442192GO:0060402
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

CACNA1C RYR2

7.10e-0443192GO:0086004
GeneOntologyBiologicalProcesspositive regulation of protein secretion

CACNA1C NCOA6 IRS2

7.10e-04194193GO:0050714
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

CACNA1C RYR2

7.43e-0444192GO:0070296
GeneOntologyBiologicalProcesspositive regulation of hormone secretion

CACNA1C NCOA6 IRS2

8.34e-04205193GO:0046887
GeneOntologyBiologicalProcessregulation of actin filament-based movement

CACNA1C RYR2

1.08e-0353192GO:1903115
GeneOntologyBiologicalProcessregulation of insulin secretion

CACNA1C NCOA6 IRS2

1.18e-03231193GO:0050796
GeneOntologyBiologicalProcesscell communication involved in cardiac conduction

CACNA1C RYR2

1.33e-0359192GO:0086065
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA1C RYR2

1.47e-0362192GO:0086002
GeneOntologyBiologicalProcessregulation of protein transport

CACNA1C NCOA6 CEP131 IRS2

1.51e-03560194GO:0051223
GeneOntologyBiologicalProcesspositive regulation of protein localization

CACNA1C NCOA6 CEP131 IRS2

1.84e-03591194GO:1903829
GeneOntologyBiologicalProcesspositive regulation of transmembrane transport

CACNA1C IRS2 RYR2

1.90e-03273193GO:0034764
GeneOntologyBiologicalProcessinsulin secretion

CACNA1C NCOA6 IRS2

1.92e-03274193GO:0030073
GeneOntologyBiologicalProcessregulation of peptide hormone secretion

CACNA1C NCOA6 IRS2

1.98e-03277193GO:0090276
GeneOntologyBiologicalProcessregulation of peptide transport

CACNA1C NCOA6 IRS2

2.08e-03282193GO:0090087
GeneOntologyBiologicalProcessregulation of peptide secretion

CACNA1C NCOA6 IRS2

2.08e-03282193GO:0002791
HumanPhenoAborted sudden cardiac death

CACNA1C RYR2

6.93e-06462HP:0031628
MousePhenoabnormal fetal cardiomyocyte physiology

CACNA1C NCOA6 RYR2

2.54e-0555153MP:0011390
MousePhenoabnormal heart layer morphology

CACNA1C BCAS3 NCOA6 RYR2 HSD17B7

5.72e-05422155MP:0010545
MousePhenoabnormal muscle morphology

AHSG CACNA1C NCOA6 IRS2 RYR2 HSD17B7 EPC1

6.95e-051106157MP:0002108
MousePhenoabnormal epicardium morphology

NCOA6 RYR2

1.45e-0417152MP:0003057
DomainEF-hand-dom_pair

CACNA1C RPTN RYR2

3.89e-03287213IPR011992
DomainIon_trans_dom

CACNA1C RYR2

7.19e-03114212IPR005821
DomainIon_trans

CACNA1C RYR2

7.19e-03114212PF00520
DomainEF-hand_1

RPTN RYR2

1.25e-02152212PF00036
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1C RYR2

7.48e-0511172M47958
PathwayKEGG_MEDICUS_REFERENCE_CARDIAC_TYPE_VGCC_RYR_SIGNALING

CACNA1C RYR2

2.84e-0421172M47950
Pubmed

Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit.

CACNA1C RYR2

3.47e-07221211576544
Pubmed

An NGS-based genotyping in LQTS; minor genes are no longer minor.

CACNA1C RYR2

1.04e-06321232681117
Pubmed

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias.

CACNA1C RYR2

2.08e-06421219383796
Pubmed

Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.

CACNA1C RYR2

3.47e-06521231663850
Pubmed

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.

CACNA1C RYR2

5.20e-06621216352659
Pubmed

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.

CACNA1C RYR2

5.20e-06621224952909
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

CACNA1C RYR2

9.70e-06821211784029
Pubmed

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels.

CACNA1C RYR2

1.56e-051021226897459
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

CACNA1C RYR2

2.28e-051221219095005
Pubmed

Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

CACNA1C RYR2

4.70e-051721227725084
Pubmed

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.

CACNA1C RYR2

1.03e-042521238877142
Pubmed

LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

CACNA1C RYR2

1.93e-043421226378152
Pubmed

Heart neurons use clock genes to control myocyte proliferation.

CACNA1C RYR2

2.28e-043721234851661
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1C RYR2

2.41e-043821230786075
Pubmed

Hdac6 regulates Tip60-p400 function in stem cells.

EPC1 HDX

3.85e-044821224302573
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

NCOA6 IRS2 HSD17B7

4.44e-0425021318660489
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

NCOA6 CNOT10

5.82e-045921228813667
GeneFamilyEF-hand domain containing

RPTN RYR2

1.21e-02219142863
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1C RYR2 ATP8B4

6.70e-051702133f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

FYB1 RYR2 ATP8B4

6.70e-051702134232fe937909f93d3736988c707b8f95ce993398
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1C BCAS3 RYR2

8.61e-05185213a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

IRS2 EPPIN SANBR

8.75e-05186213ed9b1a784f67e8a297e2a10993a6d97df60581ac
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C RYR2 SANBR

9.03e-051882139cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C RYR2 SANBR

9.03e-051882136468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1C RYR2 SANBR

9.03e-051882137a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FYB1 IRS2 ATP8B4

9.47e-05191213468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

CACNA1C BCAS3 RYR2

9.76e-051932135896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C IRS2 RYR2

9.91e-05194213e93de9428c986b8943fc169258847c650cfab0e5
ToppCellCOPD-Lymphoid-T|COPD / Disease state, Lineage and Cell class

FYB1 RYR2 EPC1

1.02e-0419621330e53b8050d2a041f855d0e39bbd8f923c64c489
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PCDHB8 CACNA1C RYR2

1.04e-04197213cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-5|TCGA-Uvea / Sample_Type by Project: Shred V9

PCDHB8 EPPIN

7.07e-0484212dc3d0733ef9d15b92784713c3b64b5d42b4ee932
ToppCellLA-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

CACNA1C RYR2

7.75e-04882127232b13a9788f89600411222c0d93bdc3788816f
ToppCellLA-06._Ventricular_Cardiomyocyte_II|LA / Chamber and Cluster_Paper

CACNA1C RYR2

8.47e-0492212fad2e02ae858e3a9bbe51ad1c689f7e31d11ce0e
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AHSG FYB1

9.41e-0497212442201932dc318846dc45f6c753e30b0d9a69f73
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AHSG FYB1

9.99e-04100212c50714a0819a40917d7a360623220576473f52ad
ToppCellRV-03._Atrial_Cardiomyocyte|RV / Chamber and Cluster_Paper

CACNA1C RYR2

1.10e-0310521249e16b11f16e83a7d17d162c14bce991201bcc2a
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

RYR2 ATP8B4

1.10e-031052128f31edf4183587f5b53941475453c5aa49f10bbd
ToppCellLV-03._Atrial_Cardiomyocyte|LV / Chamber and Cluster_Paper

CACNA1C RYR2

1.43e-031202123b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCellRV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

CACNA1C RYR2

1.48e-031222121cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCellLV-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

CACNA1C RYR2

1.68e-03130212a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FYB1 CEP131

1.68e-03130212c63f402d6ab71c2fcef12174b3139e55a727266c
ToppCellRA-06._Ventricular_Cardiomyocyte_II|RA / Chamber and Cluster_Paper

CACNA1C RYR2

1.73e-0313221282674ec4b0a416e4f08372b86c2a475afe3f38a5
ToppCellRA-15._Ventricular_Cardiomyocyte_III|RA / Chamber and Cluster_Paper

CACNA1C RYR2

1.78e-0313421260ee3accc54108e5b9a0018f6aa8488dc39d5ade
ToppCellRA-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

CACNA1C RYR2

1.81e-031352126121b1d30d05b7d476661b932f51191da09dfeeb
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|343B / Donor, Lineage, Cell class and subclass (all cells)

FYB1 ZSCAN4

1.86e-03137212885e4cfc237eca1fa2eb1f2fd8d84f151e21ecfa
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCAS3 HSD17B7

1.86e-03137212e9b88ad86b75454a8292a94879c5b665adc42744
ToppCellRA-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

CACNA1C RYR2

1.89e-031382125a713f24f633de463ef47ca37fbb2bb60c7fdb77
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

KIAA1210 RYR2

2.00e-031422127b6678a73d04feac12bbc909f2df478215511de0
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

KIAA1210 RYR2

2.00e-03142212347f5832a86f4e41752e36e3e737df7ca6f79e90
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.05e-031442121efa434e577d1f87e02df01667782f414d63bd60
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.05e-03144212c0c5f254a960ba5e5f1354599d54e77360e6c2ac
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor|bone_marrow / Manually curated celltypes from each tissue

ATP8B4 SANBR

2.11e-03146212035393166f3ad5ab95602a8ae11b7d0ee4b1d691
ToppCellLA-15._Ventricular_Cardiomyocyte_III|LA / Chamber and Cluster_Paper

CACNA1C RYR2

2.14e-031472128970eb6b82589f39439c61a57d999661ec8342de
ToppCellE16.5-samps-Myeloid-Fetal_macrophage-Proliferative_Myeloid|E16.5-samps / Age Group, Lineage, Cell class and subclass

FYB1 ATP8B4

2.28e-03152212e427758a6e39052616a0d8ecec0c1299e81d1d3c
ToppCellE16.5-samps-Myeloid-Fetal_macrophage|E16.5-samps / Age Group, Lineage, Cell class and subclass

FYB1 ATP8B4

2.31e-03153212e9567966fe4426176e2f2dc0be4832c769c9903a
ToppCellNS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ZSCAN4 HDX

2.31e-03153212859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high|E18.5-samps / Age Group, Lineage, Cell class and subclass

NCOA6 RYR2

2.34e-03154212212c340a096a3a9669d1aebd61c045cf1402a868
ToppCellCOVID-19-Myeloid-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

FYB1 ATP8B4

2.40e-03156212a07a9096799e4ba663841c70035b4b32c1fda4f9
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FYB1 ZSCAN4

2.40e-03156212f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.43e-03157212904cd98ae85ed6459e0663f077ac462842bf12df
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.43e-03157212552fd5d09bbe81f58404ec38166feb30fc84def5
ToppCellfacs-Lung-Endomucin_-18m-Myeloid|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.43e-031572122b60de520edf167f5ca790b478557a778435b3d9
ToppCellE15.5-Hematopoietic-Immune-immune_cell_unspecified|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FYB1 ATP8B4

2.43e-031572124263627911657e788a1d0230690ee434e8a4f9a1
ToppCellE15.5-Hematopoietic-Immune|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FYB1 ATP8B4

2.43e-03157212de689a133863ed74d848eba0a4f392357ac28245
ToppCellE15.5-Hematopoietic|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FYB1 ATP8B4

2.43e-031572126315aef4b9bf673069d43a730d4e940011509ac1
ToppCellMonocytes-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

FYB1 IRS2

2.46e-03158212c3096b3a914a1a15ebe3664613e94b951f8555fc
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.46e-03158212ac7aef01eda1dca80d6c5b508649fcad55803a67
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

CACNA1C RYR2

2.46e-031582128d64c0c9de910a3f4658778642d183c8b9b6f6a2
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.46e-03158212ad1040bce6ad655c2502d9abb02507ecff177f83
ToppCellE17.5-Hematopoietic|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FYB1 ATP8B4

2.49e-03159212a5648f731f1a22d1af1be2b0e1b80e29d05bae04
ToppCellAdult-Mesenchymal-chondrocyte|Adult / Lineage, Cell type, age group and donor

CACNA1C RYR2

2.49e-031592123f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.49e-03159212dd9059f98eec43adbcc0cd42bb155670f7a3a479
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CEP131 ATP8B4

2.49e-031592127c2f70a7cba880115ccd676fb6c5f18488a5b74f
ToppCellcontrol-NK_CD56bright|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FYB1 ATP8B4

2.52e-03160212f49c810072604c4dee51025073c9e088c00daf4a
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.52e-031602123a5a7984d9ffcb0fbada02b95ffd7aca091acf30
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.52e-0316021232a105b99fc565c944672f518d6947dcf9ea8832
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

CACNA1C RYR2

2.52e-03160212fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.52e-031602129e238e7cb31070a5b9da73b4bfddde54b969b0fd
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.56e-03161212f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

CACNA1C RYR2

2.56e-0316121264891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCellE17.5-Hematopoietic-Immune|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FYB1 ATP8B4

2.56e-03161212e3ff08d0b9c686253556c56ee88648206751ef2b
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.56e-0316121258a32a1033f379579697bda1bbf047a088e4a34f
ToppCellE17.5-Hematopoietic-Immune-immune_cell_unspecified|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FYB1 ATP8B4

2.56e-0316121230741ca6548db2dfb5cf1faecf0d7412c91d0077
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.56e-0316121216f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.62e-0316321245a0a03d642a9751f522b2f068598ab5de4a87bd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CEP131 ATP8B4

2.62e-031632121c014e373667be290d7fb5d24c06c6f313ac8fa3
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C HSD17B7

2.62e-031632128f24cef152f5965727bbeee116bd26c75cbba82a
ToppCellBasal_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

NCOA6 RYR2

2.65e-03164212b15a26130a1ea1b370b6e3be21f02a0d6aaf6b3c
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

CACNA1C RYR2

2.65e-031642122ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CNOT10 ATP8B4

2.65e-031642123a4ecc632be003d09b765c992804134348d2278b
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CNOT10 ATP8B4

2.65e-031642124b10b78d4d76023c3c5bcd427757218fdd5465ca
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.68e-03165212475905d608fac628960188ae4a18010b8097417e
ToppCellE18.5-Immune-Immune_Myeloid|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.68e-0316521257de10d9237e56fafaa58995792f998fecc77e7a
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C RYR2

2.68e-031652128a82e20c9b1156bb4bbc16f7785abb04458d671b
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FYB1 ATP8B4

2.71e-03166212f03f78cae6272c89618c0bda032ce45c4fc96baa
ToppCellfacs-Heart-LA-24m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPTN RYR2

2.71e-03166212c43aec09578975df8984886993d15b42a10190c8
ToppCellfacs-Heart-LA-24m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPTN RYR2

2.71e-03166212829a8998ce68739a58202851afd73e049ab0f84f
ToppCellNS-critical-d_0-4-Epithelial-unknown_epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCOA6 HDX

2.71e-03166212dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.71e-03166212d80c2522cf314d56730d60f160b1247933443378
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D122|Adult / Lineage, Cell type, age group and donor

FYB1 ATP8B4

2.71e-03166212be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Lymphocytic-mature_NK_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.71e-03166212410843ad44f9b22d5476119ac0d7c9168e17ac4b
ToppCellDendritic_Cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

FYB1 IRS2

2.71e-03166212fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FYB1 ATP8B4

2.71e-03166212f2593e2f1043a8cedaa677a73e6b28393991b910
ToppCellPND01-03-samps-Myeloid|PND01-03-samps / Age Group, Lineage, Cell class and subclass

FYB1 ATP8B4

2.71e-0316621299dc8a186ec12d3563e81fa4618a814740332c73
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-TRGV5/7_gdT|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FYB1 ATP8B4

2.75e-0316721218e336faa2d2429ab49d1c6ae9bbf9923d74aa8d
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th1|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FYB1 RYR2

2.75e-031672129c55ec8f70b86d4d3d5c2a6ecd9bff2dafe68c11
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.75e-031672128aacb102c1b0067a86eb6c2acedd07667198487d
ToppCellE18.5-Immune|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FYB1 ATP8B4

2.75e-031672120878ea803621a139c91016a7fb49b59ccc502c1a
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FYB1 ATP8B4

2.75e-031672120d187e40a5b96b595761f7aea1a0835462d8270f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CEP131 IRS2

2.75e-03167212b4ef07117d14da3d5fbced949e4dfcb01c392295
ToppCellsevere-CD4+_T_naive|severe / disease stage, cell group and cell class

FYB1 BCAS3

2.75e-0316721202a8215fca59c357c1cdaa5738849eacf98c0bcc
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CEP131 IRS2

2.75e-0316721294fc7df7ca55cd722a8dbd153201a29891217473
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CEP131 IRS2

2.75e-03167212eff3723fe60755272eca237459165e436e919ece
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZBTB5 ZSCAN4

2.75e-03167212d1a13d6ada572d8ddb2da95e6e122d2b705fad7f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

FYB1 EPC1

2.75e-03167212ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP8B4 HSD17B7

2.78e-031682129e7b4b9b977e90e083f5164013e79df8bc2d492e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IRS2 ATP8B4

2.78e-0316821226fce414439ccd204e3acb41f2b4f75072df5a26
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ATP8B4 SANBR

2.78e-03168212d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
Diseaseextrapulmonary tuberculosis

ZBTB5 CACNA1C

2.58e-0512192MONDO_0000368
Diseasecalcium measurement

AHSG BCAS3 NCOA6 IRS2 SANBR

3.90e-05628195EFO_0004838
DiseaseHypertrophic Cardiomyopathy

CACNA1C RYR2

6.14e-0457192C0007194
Diseasemetabolite measurement, diet measurement

AHSG BCAS3

9.51e-0471192EFO_0004725, EFO_0008111
Diseaseplatelet component distribution width

FYB1 CACNA1C IRS2 EPC1

1.21e-03755194EFO_0007984
Diseaseforced expiratory volume

BCAS3 NCOA6 RYR2 ATP8B4

1.43e-03789194EFO_0004314
Diseasered blood cell density measurement

FYB1 CACNA1C BCAS3 IRS2

2.13e-03880194EFO_0007978
Diseasecreatinine measurement, glomerular filtration rate

BCAS3 NCOA6

2.55e-03117192EFO_0004518, EFO_0005208
Diseaseplatelet crit

FYB1 CACNA1C BCAS3 IRS2

2.83e-03952194EFO_0007985
Diseasesleep measurement

FYB1 RYR2

3.38e-03135192EFO_0004870
Diseasetype 2 diabetes mellitus (is_implicated_in)

AHSG IRS2

5.35e-03171192DOID:9352 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
QNLASNQQKSGFRLN

EPC1

621

Q9H2F5
AKQNLFGQNRNFSNG

ATP8B4

716

Q8TF62
GKLNSQDSYNNFTNN

BCAS3

496

Q9H6U6
QLRLSQNQNNYQISG

HDX

406

Q7Z353
GIQARKNLFNNQGNA

FYB1

31

O15117
ATNAQQGQRNASQGK

NFYC

271

Q13952
SAGHFGVNNKQNNTN

NCOA6

896

Q14686
NNNNNNNNHSVRKCG

IRS2

21

Q9Y4H2
SNANINNANNTALGR

CACNA1C

1811

Q13936
AALAAFNAQNNGSNF

AHSG

166

P02765
ALNRNFNQQGLYSNV

HSD17B7

206

P56937
GDGNNNQHANLSNQD

KIAA1210

1456

Q9ULL0
NSDFQNYLRTQTGNN

RYR2

3851

Q92736
NFTANNRSNKGAVGN

CEP131

166

Q9UPN4
QNSNFRNGFGFSLQL

PCDHB8

786

Q9UN66
VYGGCQGNNNNFQSK

EPPIN

106

O95925
MSRGYSENNNFLNNN

SANBR

1

Q6NSI8
QGNNNKNGKNETGNN

CNOT10

181

Q9H9A5
NFLNKSRGNNFTANQ

ZBTB5

411

O15062
SRGNNFTANQNNDDN

ZBTB5

416

O15062
NNLGSENSAFQQSQG

ZSCAN4

16

Q8NAM6
NQGQGFQSRDSQQNG

RPTN

631

Q6XPR3