Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	3.92e-07	884	45	12	GO:0004930
GeneOntologyMolecularFunction	neuropeptide binding	CMKLR2 NPY4R2 GALR1 NPY4R	1.41e-06	37	45	4	GO:0042923
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 ROS1 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	5.65e-06	1353	45	13	GO:0004888
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	2.97e-05	4	45	2	GO:0001602
GeneOntologyMolecularFunction	gap junction channel activity involved in cell communication by electrical coupling	GJC2 GJB6	1.77e-04	9	45	2	GO:1903763
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPY4R2 GALR1 NPY4R	2.32e-04	53	45	3	GO:0008188
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC9B1P1 GJC2 SLC7A13 SLC30A1 SLC25A25 CLCC1 PIEZO1 GJB6 SLC43A1 RYR2	2.39e-04	1180	45	10	GO:0022857
GeneOntologyMolecularFunction	peptide hormone binding	CMKLR2 GALR1 NPY4R	2.59e-04	55	45	3	GO:0017046
GeneOntologyMolecularFunction	antiporter activity	SLC9B1P1 SLC7A13 SLC30A1 SLC25A25	2.61e-04	138	45	4	GO:0015297
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	2.70e-04	11	45	2	GO:0004983
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T2 OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	3.90e-04	431	45	6	GO:0004984
GeneOntologyMolecularFunction	transporter activity	SLC9B1P1 GJC2 SLC7A13 SLC30A1 SLC25A25 CLCC1 PIEZO1 GJB6 SLC43A1 RYR2	4.84e-04	1289	45	10	GO:0005215
GeneOntologyMolecularFunction	gap junction channel activity	GJC2 GJB6	1.44e-03	25	45	2	GO:0005243
GeneOntologyMolecularFunction	hormone binding	CMKLR2 GALR1 NPY4R	1.62e-03	103	45	3	GO:0042562
GeneOntologyMolecularFunction	wide pore channel activity	GJC2 GJB6	3.15e-03	37	45	2	GO:0022829
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPY4R2 GALR1 NPY4R	3.34e-03	133	45	3	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPY4R2 GALR1 NPY4R	3.86e-03	140	45	3	GO:0001653
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC9B1P1 SLC7A13 SLC30A1 SLC25A25	4.37e-03	296	45	4	GO:0015291
GeneOntologyMolecularFunction	amide binding	CMKLR2 GALR1 NPY4R RYR2	4.53e-03	299	45	4	GO:0033218
GeneOntologyMolecularFunction	peptide binding	CMKLR2 NPY4R2 GALR1 NPY4R	5.63e-03	318	45	4	GO:0042277
GeneOntologyMolecularFunction	channel activity	GJC2 CLCC1 PIEZO1 GJB6 RYR2	6.33e-03	525	45	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	GJC2 CLCC1 PIEZO1 GJB6 RYR2	6.38e-03	526	45	5	GO:0022803
GeneOntologyBiologicalProcess	detection of stimulus	OPN1LW OR2T2 OR4C12 OR10A2 OR1I1 OR4A16 PIEZO1 RYR2 OR10A5	2.15e-05	722	45	9	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	3.10e-05	1395	45	12	GO:0007186
GeneOntologyBiologicalProcess	cell communication by electrical coupling	GJC2 GJB6 RYR2	6.05e-05	35	45	3	GO:0010644
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2T2 OR4C12 OR10A2 OR1I1 OR4A16 RYR2 OR10A5	1.29e-04	524	45	7	GO:0009593
GeneOntologyBiologicalProcess	neuropeptide signaling pathway	CMKLR2 NPY4R2 GALR1 NPY4R	1.53e-04	124	45	4	GO:0007218
GeneOntologyCellularComponent	proximal neuron projection	TRIM46 GJC2	4.51e-05	5	45	2	GO:1990769
GeneOntologyCellularComponent	COPII vesicle coat	SEC24D SEC24C	5.33e-04	16	45	2	GO:0030127
Domain	GPCR_Rhodpsn_7TM	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	2.28e-08	670	43	12	IPR017452
Domain	7tm_1	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	2.55e-08	677	43	12	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	2.91e-08	685	43	12	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	3.20e-08	691	43	12	PS50262
Domain	GPCR_Rhodpsn	OPN1LW CMKLR2 OR2T2 CCR3 OR4C12 NPY4R2 OR10A2 GALR1 OR1I1 NPY4R OR4A16 OR10A5	3.25e-08	692	43	12	IPR000276
Domain	NPY4_rcpt	NPY4R2 NPY4R	5.18e-06	2	43	2	IPR001933
Domain	Sec23/24_helical_dom	SEC24D SEC24C	7.72e-05	6	43	2	IPR006900
Domain	Sec23/24_trunk_dom	SEC24D SEC24C	7.72e-05	6	43	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC24D SEC24C	7.72e-05	6	43	2	IPR006895
Domain	Sec23_24_beta_S	SEC24D SEC24C	7.72e-05	6	43	2	IPR012990
Domain	zf-Sec23_Sec24	SEC24D SEC24C	7.72e-05	6	43	2	PF04810
Domain	Sec23_trunk	SEC24D SEC24C	7.72e-05	6	43	2	PF04811
Domain	Sec23_helical	SEC24D SEC24C	7.72e-05	6	43	2	PF04815
Domain	Sec23_BS	SEC24D SEC24C	7.72e-05	6	43	2	PF08033
Domain	NPY_rcpt	NPY4R2 NPY4R	1.84e-04	9	43	2	IPR000611
Domain	Olfact_rcpt	OR2T2 OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	2.64e-04	393	43	6	IPR000725
Domain	Gelsolin	SEC24D SEC24C	4.63e-04	14	43	2	PF00626
Domain	Gelsolin-like_dom	SEC24D SEC24C	4.63e-04	14	43	2	IPR007123
Domain	CONNEXINS_1	GJC2 GJB6	8.64e-04	19	43	2	PS00407
Domain	Connexin_N	GJC2 GJB6	9.58e-04	20	43	2	IPR013092
Domain	CONNEXINS_2	GJC2 GJB6	9.58e-04	20	43	2	PS00408
Domain	Connexin	GJC2 GJB6	9.58e-04	20	43	2	PF00029
Domain	Connexin_CCC	GJC2 GJB6	9.58e-04	20	43	2	SM01089
Domain	Connexin_CS	GJC2 GJB6	9.58e-04	20	43	2	IPR017990
Domain	Connexin	GJC2 GJB6	9.58e-04	20	43	2	IPR000500
Domain	Connexin_CCC	GJC2 GJB6	9.58e-04	20	43	2	IPR019570
Domain	CNX	GJC2 GJB6	9.58e-04	20	43	2	SM00037
Domain	-	SEC24D SEC24C	1.38e-03	24	43	2	3.40.20.10
Domain	ADF-H/Gelsolin-like_dom	SEC24D SEC24C	1.38e-03	24	43	2	IPR029006
Domain	EF-hand_8	SLC25A25 RYR2	2.77e-03	34	43	2	PF13833
Domain	ARM-type_fold	MROH7 INF2 LYST NEK10	7.54e-03	339	43	4	IPR016024
Domain	-	SEC24D SEC24C	1.26e-02	74	43	2	3.40.50.410
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OPN1LW CMKLR2 CCR3 GALR1 OR1I1 NPY4R OR10A5	1.90e-06	260	33	7	M39397
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OPN1LW CCR3 OR10A2 GALR1 NPY4R OR10A5	4.01e-06	186	33	6	MM15994
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T2 OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	2.50e-04	389	33	6	M14091
Pathway	KEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION	SEC24D SEC24C	3.46e-04	12	33	2	M47770
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T2 OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	3.63e-04	417	33	6	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OPN1LW OR2T2 OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	5.63e-04	636	33	7	M41834
Pathway	WP_GPCRS_PEPTIDE	CCR3 GALR1 NPY4R	5.75e-04	70	33	3	MM15959
Pathway	WP_PEPTIDE_GPCRS	CCR3 GALR1 NPY4R	7.04e-04	75	33	3	M39696
Pathway	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	SEC24D SEC24C	1.54e-03	25	33	2	MM15713
Pubmed	Panglial gap junctional communication is essential for maintenance of myelin in the CNS.	GJC2 GJB6	1.64e-06	2	45	2	22649229
Pubmed	A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export.	SEC24D SEC24C	4.91e-06	3	45	2	22404651
Pubmed	Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells.	GJC2 GJB6	4.91e-06	3	45	2	25037920
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	4.91e-06	3	45	2	8643460
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2T2 OR4C12 OR10A2 OR1I1 OR10A5	9.41e-06	219	45	5	12213199
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	9.81e-06	4	45	2	7592911
Pubmed	The physical and genetic map surrounding the Lyst gene on mouse chromosome 13.	LYST RYR2	9.81e-06	4	45	2	9070932
Pubmed	Murine SEC24D can substitute functionally for SEC24C during embryonic development.	SEC24D SEC24C	9.81e-06	4	45	2	34702932
Pubmed	Mammalian COPII coat component SEC24C is required for embryonic development in mice.	SEC24D SEC24C	1.63e-05	5	45	2	24876386
Pubmed	A contextual model for axonal sorting into glomeruli in the mouse olfactory system.	OR10A2 OR10A5	1.63e-05	5	45	2	15186781
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	1.63e-05	5	45	2	7493937
Pubmed	Sec24 proteins and sorting at the endoplasmic reticulum.	SEC24D SEC24C	2.45e-05	6	45	2	10075675
Pubmed	A family of mammalian proteins homologous to yeast Sec24p.	SEC24D SEC24C	2.45e-05	6	45	2	10329445
Pubmed	Selective export of human GPI-anchored proteins from the endoplasmic reticulum.	SEC24D SEC24C	3.42e-05	7	45	2	20427317
Pubmed	Genomic analysis of orthologous mouse and human olfactory receptor loci.	OR10A2 OR10A5	5.86e-05	9	45	2	11416212
Pubmed	Comparative mapping in the beige-satin region of mouse chromosome 13.	LYST RYR2	7.32e-05	10	45	2	9027500
Pubmed	The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope.	SEC24D SEC24C	7.32e-05	10	45	2	17499046
Pubmed	Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.	SEC24D SEC24C	7.32e-05	10	45	2	18843296
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	7.69e-05	340	45	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	7.69e-05	340	45	5	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	8.01e-05	343	45	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4C12 OR10A2 OR1I1 OR4A16 OR10A5	8.34e-05	346	45	5	14611657
Pubmed	Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.	SEC24D SEC24C	1.07e-04	12	45	2	20215345
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	LYST RYR2	1.47e-04	14	45	2	11472062
Pubmed	An expression atlas of connexin genes in the mouse.	GJC2 GJB6	2.47e-04	18	45	2	15081111
Pubmed	The novel mouse connexin39 gene is expressed in developing striated muscle fibers.	GJC2 GJB6	2.47e-04	18	45	2	15466892
Pubmed	An update on connexin genes and their nomenclature in mouse and man.	GJC2 GJB6	2.76e-04	19	45	2	14681012
Pubmed	The ULK1-FBXW5-SEC23B nexus controls autophagy.	SEC24D SEC24C	3.06e-04	20	45	2	30596474
Pubmed	Use of (alternative) coreceptors for HIV entry.	CMKLR2 CCR3	3.38e-04	21	45	2	22842622
Pubmed	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.	DHH RYR2	3.38e-04	21	45	2	31712577
Pubmed	The COPII cargo adapter SEC24C is essential for neuronal homeostasis.	SEC24D SEC24C	5.22e-04	26	45	2	29939162
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	MROH7 CMKLR2 DYM	5.76e-04	125	45	3	17062627
Pubmed	The human olfactory receptor gene family.	OR2T2 OR4C12 OR10A2 OR4A16 OR10A5	6.54e-04	541	45	5	14983052
Pubmed	Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.	GJC2 GALR1	6.96e-04	30	45	2	27568567
Pubmed	Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.	OPN1LW ESRRB	7.92e-04	32	45	2	25757744
Pubmed	The developing mouse coronal suture at single-cell resolution.	SOST GJB6	1.06e-03	37	45	2	34376651
Pubmed	The transcription factor XBP1 is selectively required for eosinophil differentiation.	SEC24D CCR3	1.06e-03	37	45	2	26147683
Pubmed	mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia.	OPN1LW EPAS1	1.24e-03	40	45	2	34677125
Cytoband	1q22	TRIM46 TSACC	1.45e-03	57	45	2	1q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	TRIM46 TSACC	2.24e-03	71	45	2	chr1q22
GeneFamily	Gap junction proteins	GJC2 GJB6	5.63e-04	22	29	2	314
GeneFamily	Solute carriers	SLC7A13 SLC30A1 SLC25A25 SLC43A1	3.46e-03	395	29	4	752
GeneFamily	Olfactory receptors, family 10	OR10A2 OR10A5	5.00e-03	66	29	2	157
GeneFamily	Actins\|Deafness associated genes	GJB6 ESRRB	1.41e-02	113	29	2	1152
GeneFamily	Olfactory receptors, family 4	OR4C12 OR4A16	1.81e-02	129	29	2	151

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCGYKEPLLSCLIIM	EPAS1	211	Q99814
VCLARQYLMGCLPLV	BICC1	341	Q9H694
SCQELCRILYLLIPL	MROH7	956	Q68CQ1
TCCIIPLAIIMLCYL	OPN1LW	226	P04000
LLILPNCQKIMCIYF	PABIR3	136	Q6P4D5
YACCVLMLLIPLSVI	OR2T2	201	Q6IF00
MCDLYPLLKLVCIDT	OR4C12	176	Q96R67
MEACCLLQLPQRLLL	LDLRAD2	1	Q5SZI1
CLLCQPLTAVYTIMD	NPY4R	91	P50391
MYVVSCLCLLLNLCE	GJC2	271	Q5T442
AMQLLCLLTCPLIGY	SLC43A1	361	O75387
LICLRLLMRDPCYQE	NEK10	136	Q6ZWH5
VCDMYPLLELLCLDT	OR4A16	176	Q8NH70
RYLVLMCSPVCGLLL	OR1I1	131	O60431
LLLLAIPCYQLRIEC	INF2	706	Q27J81
IPCYQLRIECMLLCE	INF2	711	Q27J81
ILVVMIPCLLILCSY	OR10A2	191	Q9H208
LPLLLICFCYAKVLN	GALR1	211	P47211
MLVPLAKLSCLAYQC	ETFDH	1	Q16134
LTMKEYHCLLQLLCP	CSTPP1	96	Q9H6J7
FCLVLPLLVMAICYT	CCR3	206	P51677
LLCCLMQLITDIPLL	DYM	151	Q7RTS9
MALLTNLLPLCCLAL	DHH	1	O43323
ICMLLNVAELCYLLL	GJB6	201	O95452
CELQFPQCLLLVVVM	C1orf112	336	Q9NSG2
IIYPEICMLELNLLS	LYST	1266	Q99698
CEYMLNAIPKRLCLV	ESRRB	91	O95718
ELLCCRKDVLMILPY	HELQ	376	Q8TDG4
ILPECMKLLPVYLNC	SEC24C	896	P53992
PVKLQMCLLLQYLCD	RYR2	1901	Q92736
PMLLVALVLGAYCLC	HS3ST6	31	Q96QI5
LVVMIPCLLILCSYT	OR10A5	206	Q9H207
LLCPVCQEMYKQPLV	TRIM46	31	Q7Z4K8
LCVRILNIYLLMCFA	SLC9B1P1	176	A6NJY1
MQLPLALCLVCLLVH	SOST	1	Q9BQB4
VLPVYMNCLLKNCVL	SEC24D	841	O94855
LFPLLTMSICYLCLI	CMKLR2	216	P46091
DPYNVLMVLLCLLCI	CLCC1	181	Q96S66
MLCLCLYVPVIGEAQ	SLC25A25	1	Q6KCM7
ECLGLLECMYANLQL	TSACC	61	Q96A04
YCILPLTVAMLICRL	YIPF6	156	Q96EC8
CLLCQPLTAVYTIMD	NPY4R2	91	P0DQD5
CLLNEPQYIILELME	ROS1	2016	P08922
KMTCYLQLLFNICLP	SLC7A13	451	Q8TCU3
ICLYCYQMPLAQALL	PIEZO1	261	Q92508
LDPTLCVVMVCILLY	SLC30A1	316	Q9Y6M5
LTCECKDLIYRMLQP	TSSK2	241	Q96PF2