Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aldehyde dehydrogenase (NAD+) activity	ADH5 ALDH1L1	3.27e-04	15	36	2	GO:0004029
GeneOntologyMolecularFunction	aldehyde dehydrogenase [NAD(P)+] activity	ADH5 ALDH1L1	4.23e-04	17	36	2	GO:0004030
GeneOntologyMolecularFunction	death receptor binding	FEM1B RIPK1	9.24e-04	25	36	2	GO:0005123
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	ADH5 ALDH1L1	3.38e-03	48	36	2	GO:0016620
Domain	AcylCo_DH/oxidase_C	FANCG ACOX1	4.26e-04	16	36	2	IPR009075
Domain	BTB-kelch_protein	KLHL41 KLHL40	3.10e-03	43	36	2	IPR017096
Domain	-	KLHL41 KLHL40	3.85e-03	48	36	2	2.120.10.80
Domain	TPR	TTC7A FEM1B FANCG	3.90e-03	165	36	3	PS50005
Domain	TPR_REGION	TTC7A FEM1B FANCG	3.90e-03	165	36	3	PS50293
Domain	ARM-type_fold	SCYL2 NBEAL1 DOCK9 RTTN	3.97e-03	339	36	4	IPR016024
Domain	Kelch-typ_b-propeller	KLHL41 KLHL40	5.03e-03	55	36	2	IPR015915
Domain	Kelch	KLHL41 KLHL40	5.58e-03	58	36	2	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KLHL41 KLHL40	5.77e-03	59	36	2	IPR011043
Domain	BACK	KLHL41 KLHL40	5.96e-03	60	36	2	SM00875
Domain	BACK	KLHL41 KLHL40	6.15e-03	61	36	2	PF07707
Domain	BACK	KLHL41 KLHL40	6.15e-03	61	36	2	IPR011705
Domain	Kelch_1	KLHL41 KLHL40	8.03e-03	70	36	2	PF01344
Domain	Kelch_1	KLHL41 KLHL40	8.03e-03	70	36	2	IPR006652
Domain	TPR-like_helical_dom	TTC7A TRAPPC10 FANCG	1.01e-02	233	36	3	IPR011990
Domain	Cys-rich_flank_reg_C	LRRC4C ELFN1	1.30e-02	90	36	2	IPR000483
Domain	LRRCT	LRRC4C ELFN1	1.30e-02	90	36	2	SM00082
Pubmed	Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy.	KLHL41 KLHL40	1.56e-05	6	36	2	30986853
Pubmed	KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.	KLHL41 KLHL40	2.18e-05	7	36	2	28826497
Pubmed	Nemaline Myopathy – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	KLHL41 KLHL40	4.66e-05	10	36	2	20301465
Pubmed	Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity.	SLC6A18 UNC93A	6.83e-05	12	36	2	28406212
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIGW ORC1 SYNJ1 DOCK9 RTTN EIF2B3 SLC52A3	1.19e-04	1105	36	7	35748872
Pubmed	KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.	KLHL41 KLHL40	1.24e-04	16	36	2	24960163
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	SCYL2 TRAPPC10 SYNJ1 NBEAL1	2.12e-04	285	36	4	34369648
Pubmed	A systematic survey of loss-of-function variants in human protein-coding genes.	SLC6A18 UNC93A	2.38e-04	22	36	2	22344438
Pubmed	Identification of a large set of rare complete human knockouts.	SLC6A18 UNC93A	2.83e-04	24	36	2	25807282
Pubmed	Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes.	SLC6A18 UNC93A	5.07e-04	32	36	2	32487729
Pubmed	The mutational constraint spectrum quantified from variation in 141,456 humans.	SLC6A18 UNC93A	5.07e-04	32	36	2	32461654
Pubmed	Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).	KLHL41 ACOX1	6.78e-04	37	36	2	16396496
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ADH5 FEM1B TRAPPC10 PIGW SYNJ1 DOCK9	7.91e-04	1084	36	6	11544199
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL41 KLHL40	8.33e-04	41	36	2	23676014
Cytoband	12q24.22	RNFT2 FBXO21	2.68e-05	10	36	2	12q24.22
GeneFamily	Kelch like\|BTB domain containing	KLHL41 KLHL40	2.20e-03	42	30	2	617
Coexpression	GSE41867_NAIVE_VS_DAY8_LCMV_EFFECTOR_CD8_TCELL_UP	ORC1 MRPS16 RIPK1 HIBCH EIF2B3	7.65e-06	200	36	5	M9467
Disease	peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease	ELFN1 CCKBR	3.93e-04	24	36	2	EFO_0003948, EFO_0009923, MONDO_0004247
Disease	cholestasis (biomarker_via_orthology)	ADH5 ALDH1L1	1.64e-03	49	36	2	DOID:13580 (biomarker_via_orthology)
Disease	urinary metabolite measurement	UNC93A HIBCH ACOX1	3.30e-03	245	36	3	EFO_0005116

Protein segments in the cluster

Peptide	Gene	Start	Entry
THYIMTILGCLFGMV	ELFN1	416	P0C7U0
TCKGKTILHYMGTST	ADH5	131	P11766
IFGTVICKAVSYLMG	CCKBR	121	P32239
ICKAVSYLMGVSVSV	CCKBR	126	P32239
LGGCLVEYMAKVHAL	BFSP2	111	Q13515
KVHTFLDYIMGGCQI	CPNE6	291	O95741
HSGMLVVAVCTKREY	NBEAL1	636	Q6ZS30
CQKPYVALIHGITMG	HIBCH	131	Q6NVY1
VCYSIGLIMKHKRYG	FBXO21	501	O94952
TCLMIAAYKGHTDVV	FEM1B	156	Q9UK73
HTYCGKGVCLLTGIM	KCNN3	516	Q9UGI6
AIKGVHSVRYLCMGA	FGF19	91	O95750
NVISHKGMIYCLGGK	KLHL41	441	O60662
TVLSHMDLVYVIGGK	KLHL40	456	Q2TBA0
GTVMTHGAYKVRIAV	LRRC4C	391	Q9HCJ2
VQVYTALGSCHRKMG	FANCG	246	O15287
MYGFMDVVCIGLIIH	MARCHF9	226	Q86YJ5
LVVIKSTMHYAGGLF	HFM1	626	A2PYH4
KLLDHTGGCMYISGV	ORC1	521	Q13415
YVHIMKEGLCSRVST	EIF2B3	301	Q9NR50
QVHSGKLVCGMVSYL	ACOX1	441	Q15067
KVLQGSITHCAEPYM	DOCK9	481	Q9BZ29
HKLGIAVCIGMASTF	RNFT2	181	Q96EX2
MVHLTTLLCKAYRGG	MRPS16	1	Q9Y3D3
LVLGALGETMCYHKS	RTTN	441	Q86VV8
FSGCLSYVKVMLGVV	SLC52A3	406	Q9NQ40
GDTMLHYLVLVTGCM	SYNJ1	71	O43426
HYLVLVTGCMSVGKI	SYNJ1	76	O43426
VGHGMICKAYAILLV	SMYD1	411	Q8NB12
AVLMGILGIYKCTFT	SCYL2	541	Q6P3W7
EIIEGMCYLHGKGVI	RIPK1	121	Q13546
IISTLGYVAIHMAGV	PIGW	306	Q7Z7B1
MCVIRGIETTGKVIY	SLC6A18	196	Q96N87
AGAVYTLALKTHVGM	ALDH1L1	511	O75891
VLYVLGAVTHVSCMI	UNC93A	321	Q86WB7
KVMGHSSLNCYIRVG	ZNF443	111	Q9Y2A4
CEAMLILGKLHYVEG	TTC7A	121	Q9ULT0
HVGGVLCVEITMYSQ	TRAPPC10	601	P48553