Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	3.54e-05	8	23	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D	5.68e-05	10	23	2	GO:0140999
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D	2.38e-04	20	23	2	GO:0042800
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	NFATC2 SOX7 RFX6 KMT2D SOX30	3.77e-04	560	23	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	NFATC2 SOX7 RFX6 KMT2D SOX30	3.96e-04	566	23	5	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NFATC2 SOX7 RFX6 CPHXL2 KMT2D CPHXL SOX30	7.80e-04	1412	23	7	GO:0000981
GeneOntologyMolecularFunction	14-3-3 protein binding	NFATC2 IRS2	1.06e-03	42	23	2	GO:0071889
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C KMT2D	1.17e-03	44	23	2	GO:0140938
GeneOntologyMolecularFunction	histone modifying activity	KMT2C KMT2D EYA2	2.23e-03	229	23	3	GO:0140993
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NFATC2 SOX7 RFX6 CPHXL2 CPHXL SOX30	2.33e-03	1244	23	6	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	NFATC2 SOX7 RFX6 CPHXL2 CPHXL SOX30	2.59e-03	1271	23	6	GO:0000987
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C KMT2D	2.76e-03	68	23	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C KMT2D	2.84e-03	69	23	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C KMT2D	3.01e-03	71	23	2	GO:0042054
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NFATC2 SOX7 RFX6 CPHXL2 CPHXL SOX30	5.16e-03	1459	23	6	GO:0000977
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2C KMT2D	6.21e-03	103	23	2	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	KMT2C KMT2D	6.45e-03	105	23	2	GO:0008170
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C KMT2D	6.93e-05	12	22	2	GO:0044666
HumanPheno	Expressive language delay	KMT2C KMT2D PTCH1	4.27e-05	56	7	3	HP:0002474
HumanPheno	Language delay	KMT2C KMT2D PTCH1	4.27e-05	56	7	3	HP:0002336
HumanPheno	Alobar holoprosencephaly	KMT2D PTCH1	5.80e-05	9	7	2	HP:0006988
HumanPheno	Anteriorly placed anus	RFX6 KMT2D PTCH1	7.67e-05	68	7	3	HP:0001545
HumanPheno	Abnormal anus morphology	KMT2C RFX6 KMT2D PTCH1	1.15e-04	224	7	4	HP:0034915
HumanPheno	Abnormality of the anus	KMT2C RFX6 KMT2D PTCH1	1.66e-04	246	7	4	HP:0004378
HumanPheno	Ectopic anus	RFX6 KMT2D PTCH1	1.96e-04	93	7	3	HP:0004397
HumanPheno	Proboscis	KMT2D PTCH1	3.36e-04	21	7	2	HP:0012806
HumanPheno	B-cell lymphoma	NFATC2 RASGRP1	3.69e-04	22	7	2	HP:0012191
MousePheno	fast extinction of fear memory	SHISA7 BEGAIN	3.28e-05	7	18	2	MP:0012319
Domain	HMG_box	SOX7 KMT2C KMT2D SOX30	3.34e-07	53	21	4	PF00505
Domain	HMG	SOX7 KMT2C KMT2D SOX30	3.60e-07	54	21	4	SM00398
Domain	HMG_box_dom	SOX7 KMT2C KMT2D SOX30	7.65e-07	65	21	4	IPR009071
Domain	FYrich_C	KMT2C KMT2D	1.20e-05	5	21	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	1.20e-05	5	21	2	IPR003888
Domain	FYRC	KMT2C KMT2D	1.20e-05	5	21	2	SM00542
Domain	FYRN	KMT2C KMT2D	1.20e-05	5	21	2	SM00541
Domain	FYRN	KMT2C KMT2D	1.20e-05	5	21	2	PF05964
Domain	FYRC	KMT2C KMT2D	1.20e-05	5	21	2	PF05965
Domain	FYRC	KMT2C KMT2D	1.20e-05	5	21	2	PS51543
Domain	FYRN	KMT2C KMT2D	1.20e-05	5	21	2	PS51542
Domain	-	SOX7 KMT2D SOX30	3.10e-05	55	21	3	1.10.30.10
Domain	PostSET	KMT2C KMT2D	1.43e-04	16	21	2	SM00508
Domain	Post-SET_dom	KMT2C KMT2D	1.43e-04	16	21	2	IPR003616
Domain	POST_SET	KMT2C KMT2D	1.43e-04	16	21	2	PS50868
Domain	EPHD	KMT2C KMT2D	2.74e-04	22	21	2	PS51805
Domain	SET	KMT2C KMT2D	9.62e-04	41	21	2	PF00856
Domain	SET	KMT2C KMT2D	1.21e-03	46	21	2	SM00317
Domain	SET_dom	KMT2C KMT2D	1.43e-03	50	21	2	IPR001214
Domain	SET	KMT2C KMT2D	1.43e-03	50	21	2	PS50280
Domain	HMG_BOX_2	SOX7 SOX30	1.66e-03	54	21	2	PS50118
Domain	C1	KMT2C RASGRP1	2.40e-03	65	21	2	SM00109
Domain	PE/DAG-bd	KMT2C RASGRP1	2.47e-03	66	21	2	IPR002219
Domain	PHD	KMT2C KMT2D	3.18e-03	75	21	2	PF00628
Domain	Znf_PHD-finger	KMT2C KMT2D	3.52e-03	79	21	2	IPR019787
Domain	ZF_RING_2	KMT2C KMT2D RNF111	4.32e-03	298	21	3	PS50089
Domain	PHD	KMT2C KMT2D	4.45e-03	89	21	2	SM00249
Domain	RING	KMT2C KMT2D RNF111	4.61e-03	305	21	3	SM00184
Domain	Znf_PHD	KMT2C KMT2D	4.64e-03	91	21	2	IPR001965
Domain	ZF_PHD_2	KMT2C KMT2D	5.05e-03	95	21	2	PS50016
Domain	ZF_PHD_1	KMT2C KMT2D	5.15e-03	96	21	2	PS01359
Domain	Znf_RING	KMT2C KMT2D RNF111	5.55e-03	326	21	3	IPR001841
Domain	-	PLEKHN1 IRS2 TNS4	9.15e-03	391	21	3	2.30.29.30
Domain	PH_dom-like	PLEKHN1 IRS2 TNS4	1.15e-02	426	21	3	IPR011993
Domain	Znf_FYVE_PHD	KMT2C KMT2D	1.17e-02	147	21	2	IPR011011
Domain	-	KMT2C KMT2D RNF111	1.33e-02	449	21	3	3.30.40.10
Domain	Znf_RING/FYVE/PHD	KMT2C KMT2D RNF111	1.41e-02	459	21	3	IPR013083
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D PTCH1	2.53e-10	3	23	3	22183980
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	4.18e-07	2	23	2	28483418
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	4.18e-07	2	23	2	36869380
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	4.18e-07	2	23	2	28967912
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	4.18e-07	2	23	2	34156443
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	4.18e-07	2	23	2	25346535
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	4.18e-07	2	23	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	4.18e-07	2	23	2	27280393
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	4.18e-07	2	23	2	36601880
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	1.25e-06	3	23	2	23932714
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	1.25e-06	3	23	2	21683083
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	2.51e-06	4	23	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	2.51e-06	4	23	2	34645806
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	2.51e-06	4	23	2	28398509
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	2.51e-06	4	23	2	24081332
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	2.51e-06	4	23	2	23129768
Pubmed	Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development.	CPHXL2 CPHXL	4.18e-06	5	23	2	26360614
Pubmed	Eyes absent: a gene family found in several metazoan phyla.	NFATC2 EYA2	4.18e-06	5	23	2	9195991
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	4.18e-06	5	23	2	32601106
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	4.18e-06	5	23	2	31127101
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	4.18e-06	5	23	2	26744420
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	6.26e-06	6	23	2	17021013
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	8.77e-06	7	23	2	30604749
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	8.77e-06	7	23	2	36598580
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	8.77e-06	7	23	2	19556342
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	1.17e-05	8	23	2	30335158
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D	1.17e-05	8	23	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D	1.17e-05	8	23	2	22266653
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	1.17e-05	8	23	2	21447625
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D	1.50e-05	9	23	2	22665483
Pubmed	CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma.	KMT2D PTCH1	1.88e-05	10	23	2	26290144
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	2.29e-05	11	23	2	37012455
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D	2.75e-05	12	23	2	27563068
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D	3.25e-05	13	23	2	17761849
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	3.25e-05	13	23	2	21502505
Pubmed	Depletion of definitive gut endoderm in Sox17-null mutant mice.	SOX7 PTCH1	3.79e-05	14	23	2	11973269
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	3.79e-05	14	23	2	12482968
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2C KMT2D	4.37e-05	15	23	2	17925232
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX7 SOX30	4.37e-05	15	23	2	30871468
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2D	4.99e-05	16	23	2	24368734
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C KMT2D	5.66e-05	17	23	2	26180087
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C KMT2D	6.36e-05	18	23	2	17500065
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2C KMT2D QSER1	6.58e-05	119	23	3	23508102
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C KMT2D	7.89e-05	20	23	2	29785026
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2C KMT2D	7.89e-05	20	23	2	19047629
Pubmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.	KMT2C KMT2D	7.89e-05	20	23	2	33431871
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX7 SOX30	8.72e-05	21	23	2	12815626
Pubmed	Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.	EYA2 PTCH1	8.72e-05	21	23	2	23055936
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D	8.72e-05	21	23	2	27626377
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	NFATC2 EYA2	9.59e-05	22	23	2	24301466
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C KMT2D	9.59e-05	22	23	2	26886794
Pubmed	Holoprosencephaly Overview	KMT2D PTCH1	1.24e-04	25	23	2	20301702
Pubmed	A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings.	SOX7 PTCH1	1.24e-04	25	23	2	19369396
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C KMT2D	1.92e-04	31	23	2	20516061
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	FNDC3B KMT2C KMT2D QSER1	2.14e-04	457	23	4	32344865
Pubmed	MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.	KMT2C KMT2D	2.18e-04	33	23	2	32439762
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	RFX6 IRS2	2.32e-04	34	23	2	33505018
Pubmed	Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.	RFX6 PTCH1	2.60e-04	36	23	2	27736991
Pubmed	Permissive ureter specification by TBX18-mediated repression of metanephric gene expression.	EYA2 PTCH1	2.60e-04	36	23	2	36960826
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2C KMT2D	3.72e-04	43	23	2	33472061
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	NFATC2 SOX30	4.25e-04	46	23	2	21779340
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KMT2C KMT2D	5.03e-04	50	23	2	37974198
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2C KMT2D	6.53e-04	57	23	2	18022353
Interaction	PAX9 interactions	KMT2C KMT2D QSER1 EYA2	9.09e-06	130	21	4	int:PAX9
Interaction	KDM6A interactions	SOX7 KMT2C KMT2D EYA2	2.16e-05	162	21	4	int:KDM6A
Interaction	KMT2D interactions	SOX7 KMT2C KMT2D EYA2	2.56e-05	169	21	4	int:KMT2D
Interaction	ERG interactions	KMT2C KMT2D QSER1 RNF111	7.53e-05	223	21	4	int:ERG
Interaction	SOX7 interactions	SOX7 KMT2C KMT2D	8.19e-05	82	21	3	int:SOX7
Interaction	IRF4 interactions	NFATC2 KMT2C KMT2D	9.12e-05	85	21	3	int:IRF4
Interaction	GSC interactions	KMT2C KMT2D QSER1	9.77e-05	87	21	3	int:GSC
Interaction	EN1 interactions	KMT2C KMT2D QSER1	1.96e-04	110	21	3	int:EN1
Interaction	PAX8 interactions	KMT2C KMT2D QSER1	2.01e-04	111	21	3	int:PAX8
Interaction	TBR1 interactions	KMT2C KMT2D QSER1	2.12e-04	113	21	3	int:TBR1
Interaction	TBXT interactions	KMT2C KMT2D QSER1	2.29e-04	116	21	3	int:TBXT
Interaction	LGALS4 interactions	RFX6 EYA2	2.58e-04	23	21	2	int:LGALS4
Interaction	UTY interactions	KMT2C KMT2D	2.58e-04	23	21	2	int:UTY
Interaction	CATSPER1 interactions	RFX6 EYA2 BEGAIN	2.92e-04	126	21	3	int:CATSPER1
Interaction	KMT2C interactions	SOX7 KMT2C KMT2D	3.50e-04	134	21	3	int:KMT2C
Interaction	RFX2 interactions	RFX6 EYA2	3.85e-04	28	21	2	int:RFX2
Interaction	NFIB interactions	SOX7 KMT2C KMT2D	4.15e-04	142	21	3	int:NFIB
Interaction	PAXIP1 interactions	SOX7 KMT2C KMT2D SOX30	4.66e-04	359	21	4	int:PAXIP1
Interaction	PAX6 interactions	KMT2C KMT2D QSER1 RNF111	5.01e-04	366	21	4	int:PAX6
Interaction	SOX5 interactions	SOX7 KMT2D QSER1	6.10e-04	162	21	3	int:SOX5
Interaction	MAFK interactions	NFATC2 KMT2D	6.74e-04	37	21	2	int:MAFK
Interaction	FHL2 interactions	SOX30 QSER1 RNF111 PTCH1	6.74e-04	396	21	4	int:FHL2
Interaction	EGR2 interactions	KMT2C KMT2D QSER1	7.13e-04	171	21	3	int:EGR2
Interaction	TLX1 interactions	KMT2C KMT2D QSER1	7.63e-04	175	21	3	int:TLX1
Interaction	RBM20 interactions	SOX7 EYA2	7.88e-04	40	21	2	int:RBM20
Interaction	NUP35 interactions	FNDC3B KMT2C KMT2D QSER1	8.70e-04	424	21	4	int:NUP35
Interaction	HNF1B interactions	KMT2C KMT2D QSER1	9.68e-04	190	21	3	int:HNF1B
Interaction	RFX6 interactions	PLEKHN1 RFX6	9.97e-04	45	21	2	int:RFX6
Interaction	KLF5 interactions	KMT2C KMT2D QSER1	1.04e-03	195	21	3	int:KLF5
Interaction	GATA2 interactions	KMT2C KMT2D QSER1	1.11e-03	199	21	3	int:GATA2
GeneFamily	SRY-boxes	SOX7 SOX30	1.09e-04	19	15	2	757
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D	3.55e-04	34	15	2	487
GeneFamily	PHD finger proteins	KMT2C KMT2D	2.47e-03	90	15	2	88
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHN1 IRS2	1.23e-02	206	15	2	682
Coexpression	GSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_24H_CD4_TCELL_UP	SECISBP2L FNDC3B SOX7 IRS2	1.96e-05	195	22	4	M4195
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHN1 NFATC2 RASGRP1	5.10e-05	141	23	3	c7043f3b024bb16bbc89e33075f5b6ced5cb9185
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFATC2 ZFR2 EYA2	7.70e-05	162	23	3	1ef3084b5766641ec07c6f488c1756239cf3fd61
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFATC2 ZFR2 EYA2	7.70e-05	162	23	3	eb2900a250fb3e08e479c727c7d3200cbcf37fbc
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRP1 SOX30 EYA2	9.35e-05	173	23	3	0a355386210a13927ea29b10b64cb059459952d4
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RASGRP1 SOX30 EYA2	9.35e-05	173	23	3	3678b300cad4effd7f49bfb043305ed512693848
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP1 SOX30 EYA2	9.51e-05	174	23	3	d9489c4196d103ead8cb6279492bbe563a222e45
ToppCell	Healthy_Control-Lymphoid-NK-CD8_T\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	PLEKHN1 RASGRP1 TNS4	9.51e-05	174	23	3	5dddb822fa51b4020e4d9318acacd19c726091d6
ToppCell	facs-Lung-EPCAM-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP1 SOX30 EYA2	9.51e-05	174	23	3	aae7ab9df5a78716034ddfd5bd47adc69912d624
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SOX7 TNS4 BEGAIN	9.84e-05	176	23	3	fc5787946f5a10056d326d070620575ae4081836
ToppCell	Nasal_Brush-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SOX7 TNS4 BEGAIN	9.84e-05	176	23	3	5daaba0853afe7d20d4635169ccd4f96e735b938
ToppCell	COPD-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	SOX7 TNS4 EYA2	1.02e-04	178	23	3	441d1dba720141891b11f404744c59834d80e6c5
ToppCell	10x3'2.3-week_17-19-Lymphocytic_T-T_NK-NK_T_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ADHFE1 SOX30 PTCH1	1.02e-04	178	23	3	a34bb693b72684cbd97ac9efff77d2d14e41be75
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	NFATC2 IRS2 QSER1	1.02e-04	178	23	3	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLEKHN1 TNS4 EYA2	1.09e-04	182	23	3	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PLEKHN1 TNS4 EYA2	1.09e-04	182	23	3	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	Adult-Immune-natural_killer_cell-D231\|Adult / Lineage, Cell type, age group and donor	NFATC2 RASGRP1 PTCH1	1.09e-04	182	23	3	dbf47bf4754d8ec3bc3ab1d5be7a6c47a7afbf43
ToppCell	Control-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	SOX7 TNS4 EYA2	1.14e-04	185	23	3	d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KMT2C RFX6 IRS2	1.16e-04	186	23	3	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 RASGRP1 PTCH1	1.20e-04	188	23	3	f8e6247bedc0ba494c5bb551539cb8ba5a97f557
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 RASGRP1 PTCH1	1.20e-04	188	23	3	8155bc5476fc333bedcc78c5ddcc8e4912536caa
ToppCell	IPF-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	SOX7 TNS4 EYA2	1.23e-04	190	23	3	4f15842b424eefadbfe451875e517cf70e29607f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 RASGRP1 PTCH1	1.27e-04	192	23	3	58a7829b411b02b422ef75e2277a868969cc23e8
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 RASGRP1 PTCH1	1.27e-04	192	23	3	ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FNDC3B KMT2C RNF111	1.29e-04	193	23	3	779276e775cb2492e8dd36436295a536084a6415
ToppCell	CV-Moderate-6\|Moderate / Virus stimulation, Condition and Cluster	NFATC2 KMT2C RASGRP1	1.33e-04	195	23	3	2b8a72d7e755b9655c7a496000d10ff06e50862b
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	NFATC2 RASGRP1 PTCH1	1.33e-04	195	23	3	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFATC2 RASGRP1 PTCH1	1.35e-04	196	23	3	0f3c7fd450aaa1f866b8558692534c0ea2a34e75
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NFATC2 RASGRP1 PTCH1	1.35e-04	196	23	3	4e1f8828413896ab8a4ec92a89d6789e8e37e05a
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NFATC2 RASGRP1 PTCH1	1.35e-04	196	23	3	6beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFATC2 RASGRP1 PTCH1	1.35e-04	196	23	3	c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	NFATC2 KMT2C RASGRP1	1.35e-04	196	23	3	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	NFATC2 RASGRP1 PTCH1	1.35e-04	196	23	3	418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFATC2 RASGRP1 PTCH1	1.35e-04	196	23	3	581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	2b3a56bb1d40bc1284a5931c4e7b373660de5402
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD8+_Tem\|COVID-19_Severe / Disease group, lineage and cell class	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	f0bac4d5c3160933ac3786cec8dadffb35d711ea
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	f73ece3aca28c0db5db0f12e026d42c6c36b9efb
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	bce0135a96910d2bace62a3408a1a6fdac0cf0df
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	ff34be81ee77efe60618641fa7c1084442b991d7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	e70e7d97823a762def3970d94a0e897981a6c922
ToppCell	T_cells-CTLs\|World / Immune cells in Kidney/Urine in Lupus Nephritis	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	2de34e20915a247bee75aa40495e23c20bb23e18
ToppCell	COVID_vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NFATC2 RASGRP1 PTCH1	1.37e-04	197	23	3	d4dfb3b561d0783cdbee4e8d27009ad81df695cb
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFATC2 RASGRP1 PTCH1	1.39e-04	198	23	3	a1b310274aa9b3d2aa1fe9488d67422bf4ac81d2
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NFATC2 RASGRP1 PTCH1	1.39e-04	198	23	3	a781fd35a7cda8b7760c2e3ddccaac7aac26c979
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NFATC2 RASGRP1 PTCH1	1.39e-04	198	23	3	76aff381403bc5a8a9cc73eb1e5dbdc0bac7de6c
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-gd_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NFATC2 RASGRP1 PTCH1	1.39e-04	198	23	3	df399674345c45738d765a8354ea8d1484572c34
ToppCell	COVID-19_Mild-Lymphoid_T/NK-gd_T\|COVID-19_Mild / Disease group, lineage and cell class	NFATC2 RASGRP1 PTCH1	1.39e-04	198	23	3	6aea5d00c417708f05b6d2dfe5a962d80864f8eb
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-gd_T\|COVID-19_Mild / Disease, condition lineage and cell class	NFATC2 RASGRP1 PTCH1	1.44e-04	200	23	3	6560753d3df2f87860b52052d4881aa45410f666
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD8+_Tem\|COVID-19_Severe / Disease, condition lineage and cell class	NFATC2 RASGRP1 PTCH1	1.44e-04	200	23	3	31859b8db7ea17e48b7b54e92f0d76aeb755e7ca
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	NFATC2 RASGRP1 PTCH1	1.44e-04	200	23	3	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IRS2 ENTPD8 EYA2	1.44e-04	200	23	3	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefh_(Cerebellum_basket_cells_1)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RFX6 SOX30	2.66e-04	47	23	2	59811807a4b5baec55505bb4c38ac684b0a49c9a
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefh_(Cerebellum_basket_cells_1)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	RFX6 SOX30	2.66e-04	47	23	2	74ed0dc55bcfe6e5f7bab42ee060692d51a39e5a
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e-Excitatory_Neuron.Sc17a7.Sema3e-Onecut2_(Layer_6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RFX6 SOX30	5.58e-04	68	23	2	5af7170acc5e4503375d84472d538e7f5dc92e1d
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RFX6 SOX30	6.43e-04	73	23	2	51bcbb57ee6c45cad88cb3e2cedab2cf3503b2a5
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	ADHFE1 ENTPD8	1.58e-03	115	23	2	f3062a7247b376e9978dc01109fb94d6dd960052
ToppCell	Control-B_memory-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RASGRP1 PTCH1	1.84e-03	124	23	2	3e987915026f503e8d072a837b6e7a34252e5c63
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZFR2 BEGAIN	1.98e-03	129	23	2	e7a15f98c3e6e4ee317e21958be3e413e3acd101
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	RASGRP1 EYA2	2.01e-03	130	23	2	6c6a8b77af08b30b424d4f5def37315d3c6e28b2
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_fibroblast-mesenchymal_B\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	RASGRP1 EYA2	2.01e-03	130	23	2	0706092f6b466585b3b4808b3b982a122d66cfcf
ToppCell	LPS-IL1RA-Lymphocytic_NKT-T_cells-iNKT-MAIT\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NFATC2 RASGRP1	2.14e-03	134	23	2	92981dc68c1b3cdc53f9cf83386c47f0c6c98ae7
ToppCell	PND01-03-samps-Mesenchymal-Pericyte-pericyte_E\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SHISA7 SOX30	2.17e-03	135	23	2	35928195cf34f055b353562c96f451aef2344d64
ToppCell	Control-B_memory-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RASGRP1 PTCH1	2.20e-03	136	23	2	94f23bef50c0beb54ed39b1a4b340f7aec4e75cd
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD8-positive,_alpha-beta_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NFATC2 RASGRP1	2.20e-03	136	23	2	9d7080f695de4ef183e3dbdc18ba464a3b8e3469
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX7 RFX6	2.23e-03	137	23	2	b831d917f5073ccff158662adb281d34f023126a
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	SHISA7 ENTPD8	2.23e-03	137	23	2	576ca865b8e8e59d23aa35cb9dafee0cf7d38e6a
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX7 RFX6	2.23e-03	137	23	2	cf3e928d9a7a7349840bb87475a42a07f65b94f0
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX7 RFX6	2.23e-03	137	23	2	5d82d6c7eef4ec7a7fae60e37fb956488314987e
ToppCell	Lymphoid-T_cells_(Cd8+_T_cell)\|World / shred on cell class and cell subclass (v4)	RASGRP1 TNS4	2.30e-03	139	23	2	c85f50fb536f4df6fa4dbdebe48e1ecea1df1121
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	PLEKHN1 SOX7	2.36e-03	141	23	2	73b3e967357cba7585d97ec9e9d48d3e94ebe31e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related-Oligodendrocyte/OPC\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	RASGRP1 EYA2	2.40e-03	142	23	2	43e72e4b9ae33768672ef90c8bbfd2ca1818c746
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	RASGRP1 EYA2	2.40e-03	142	23	2	d2d150e3019a5b7b143e50b1c1c2b6764abf36bf
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TNS4 EYA2	2.43e-03	143	23	2	28e936c298a45f88d14f0146caf3d5a22d483cd5
ToppCell	facs-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IRS2 TNS4	2.53e-03	146	23	2	26493014daa432db721613ef480d133f3da9eb58
ToppCell	Healthy-B_cell\|World / disease group, cell group and cell class	NFATC2 RASGRP1	2.53e-03	146	23	2	588359d3df6ad7090b7fa6c7f8d29cc1717e7f4f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RASGRP1 ZFR2	2.53e-03	146	23	2	deeb2c90a478deac7805e1f0d1466bf5bc42f746
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX30 PTCH1	2.53e-03	146	23	2	669001b772b6d6109a09727619ed5829122b48db
ToppCell	Mild/Remission-B_naive-4\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SECISBP2L IRS2	2.60e-03	148	23	2	dd5e1bc02824e743e1c030a303e32f27a359a8ca
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASGRP1 TNS4	2.60e-03	148	23	2	438fe292d29be0206e1d9fd59ede5f8368f13665
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNS4 EYA2	2.63e-03	149	23	2	dede8ffc14ce63e0058bde1394b31bb4088996b3
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CPHXL2 PTCH1	2.63e-03	149	23	2	aedbae2dffa1e880e5c6a146b6d5a135e7f54308
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNS4 EYA2	2.63e-03	149	23	2	97015942c4ac797e1c12a1673cd147c10450b15a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNS4 EYA2	2.67e-03	150	23	2	65ad642cd237ba0db4bde7371533884db2fa0aae
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KMT2D QSER1	2.74e-03	152	23	2	0652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCell	Adult-Epithelial-basal_cell-D175\|Adult / Lineage, Cell type, age group and donor	TNS4 EYA2	2.77e-03	153	23	2	9ee3e7f3f19a2474283c1c79045269686f35a541
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial-Progenitor_(NEUROG3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RFX6 EYA2	2.77e-03	153	23	2	20786807bba3bcd70ce744f8b6454e064199ed9f
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 RASGRP1	2.81e-03	154	23	2	ec920cae12ea1d14b6c973f6e903f895f80e3c50
ToppCell	Adult-Epithelial-basal_cell-D122\|Adult / Lineage, Cell type, age group and donor	TNS4 EYA2	2.81e-03	154	23	2	38d346402417960044ae999e61f0092b46f2b591
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASGRP1 TNS4	2.81e-03	154	23	2	d0a1ff02a7e91f6923aa85b65094f78e357e377d
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NFATC2 RASGRP1	2.81e-03	154	23	2	c663e9834be0b45389a862dc3c13a1f988a3e5ee
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SHISA7 RFX6	2.85e-03	155	23	2	498e52e2364ff44d3c0c707ba22468217031f5bd
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFATC2 BEGAIN	2.85e-03	155	23	2	d76a0f99ec35560d18820f9c92b69364ef2250e3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFATC2 BEGAIN	2.85e-03	155	23	2	82e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NFATC2 RNF111	2.85e-03	155	23	2	b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFATC2 BEGAIN	2.85e-03	155	23	2	979c1d53b435a82c57d16707eed8ba7346326866
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADHFE1 RNF111	2.92e-03	157	23	2	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TNS4 EYA2	2.92e-03	157	23	2	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	Basal_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	TNS4 EYA2	2.95e-03	158	23	2	51e3ed1b91b010404d66e3e7efdbffc0c815e25b
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TNS4 EYA2	2.95e-03	158	23	2	d78e7e52657dc094430291fec07e9c298be9e584
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX7 SOX30	2.95e-03	158	23	2	f296ca24fdedc33f1d24b79e7660763114ce7fa3
Drug	Plant Oils	SECISBP2L NFATC2 IRS2 TNS4 QSER1	7.33e-05	496	21	5	ctd:D010938
Drug	acetophenone	ADHFE1 PTCH1	3.95e-04	32	21	2	CID000007410
Drug	BW-B 70C; Up 200; 31.6uM; MCF7; HT_HG-U133A_EA	SECISBP2L FNDC3B IRS2	4.84e-04	169	21	3	1132_UP
Drug	fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA	IRS2 QSER1 PTCH1	5.10e-04	172	21	3	1017_UP
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	IRS2 QSER1 PTCH1	5.18e-04	173	21	3	1016_UP
Drug	Isoflupredone acetate [338-98-7]; Up 200; 9.6uM; HL60; HT_HG-U133A	SECISBP2L IRS2 PTCH1	5.27e-04	174	21	3	1873_UP
Drug	Chlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; MCF7; HT_HG-U133A	FNDC3B IRS2 PTCH1	5.45e-04	176	21	3	5291_UP
Drug	pyrvinium pamoate; Up 200; 1.25uM; MCF7; HT_HG-U133A_EA	RASGRP1 IRS2 KMT2D	5.54e-04	177	21	3	870_UP
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	SECISBP2L IRS2 PTCH1	6.40e-04	186	21	3	1664_UP
Drug	TE 5	SOX7 KMT2C	6.50e-04	41	21	2	CID003083341
Drug	Thonzonium bromide [553-08-2]; Up 200; 6.8uM; MCF7; HT_HG-U133A	IRS2 BEGAIN PTCH1	6.50e-04	187	21	3	5678_UP
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; MCF7; HT_HG-U133A	IRS2 QSER1 BEGAIN	7.23e-04	194	21	3	5531_UP
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; HL60; HT_HG-U133A	KMT2D BEGAIN PTCH1	7.34e-04	195	21	3	2333_UP
Drug	Fluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A	SECISBP2L QSER1 PTCH1	7.56e-04	197	21	3	6219_UP
Drug	Thiocolchicoside [602-41-5]; Up 200; 7uM; MCF7; HT_HG-U133A	IRS2 BEGAIN PTCH1	7.68e-04	198	21	3	5520_UP
Drug	Acacetin [480-44-4]; Up 200; 14uM; PC3; HT_HG-U133A	TNS4 SOX30 EYA2	7.68e-04	198	21	3	3767_UP
Drug	Aztreonam [78110-38-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	ZFR2 IRS2 SOX30	7.90e-04	200	21	3	5535_UP
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	4.82e-07	2	21	2	DOID:0080598 (implicated_via_orthology)
Disease	hemoglobin A1 measurement	FNDC3B SOX7 RASGRP1 IRS2 EYA2	2.69e-05	520	21	5	EFO_0007629
Disease	lung squamous cell carcinoma (is_implicated_in)	KMT2D PTCH1	1.32e-04	24	21	2	DOID:3907 (is_implicated_in)
Disease	Sezary Syndrome	KMT2C KMT2D	1.68e-04	27	21	2	C0036920
Disease	Adult Medulloblastoma	IRS2 PTCH1	4.28e-04	43	21	2	C0278876
Disease	Childhood Medulloblastoma	IRS2 PTCH1	4.28e-04	43	21	2	C0278510
Disease	Melanotic medulloblastoma	IRS2 PTCH1	4.28e-04	43	21	2	C1275668
Disease	Medullomyoblastoma	IRS2 PTCH1	4.28e-04	43	21	2	C0205833
Disease	Desmoplastic Medulloblastoma	IRS2 PTCH1	4.28e-04	43	21	2	C0751291
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2C KMT2D	4.69e-04	45	21	2	DOID:3748 (is_implicated_in)
Disease	lung adenocarcinoma (is_implicated_in)	KMT2C PTCH1	5.56e-04	49	21	2	DOID:3910 (is_implicated_in)
Disease	Medulloblastoma	IRS2 PTCH1	5.79e-04	50	21	2	C0025149
Disease	Drugs used in diabetes use measurement	NFATC2 RASGRP1 PTCH1	7.56e-04	255	21	3	EFO_0009924
Disease	congenital heart disease (implicated_via_orthology)	KMT2C KMT2D	1.10e-03	69	21	2	DOID:1682 (implicated_via_orthology)
Disease	stomach cancer (is_implicated_in)	KMT2C PTCH1	1.20e-03	72	21	2	DOID:10534 (is_implicated_in)
Disease	esophagus squamous cell carcinoma (is_marker_for)	KMT2D PTCH1	1.26e-03	74	21	2	DOID:3748 (is_marker_for)
Disease	chronic obstructive pulmonary disease	FNDC3B RFX6 QSER1 PTCH1	1.28e-03	688	21	4	EFO_0000341
Disease	non-small cell lung carcinoma	SECISBP2L BEGAIN	1.30e-03	75	21	2	EFO_0003060
Disease	lung adenocarcinoma (is_marker_for)	KMT2C SOX30	1.66e-03	85	21	2	DOID:3910 (is_marker_for)
Disease	hypertrophic cardiomyopathy	FNDC3B KMT2C	1.94e-03	92	21	2	EFO_0000538
Disease	Squamous cell carcinoma of esophagus	KMT2C KMT2D	2.07e-03	95	21	2	C0279626
Disease	serum alanine aminotransferase measurement	FNDC3B SOX7 EYA2 PTCH1	3.00e-03	869	21	4	EFO_0004735
Disease	smoking behavior, BMI-adjusted waist circumference	FNDC3B PTCH1	3.38e-03	122	21	2	EFO_0004318, EFO_0007789
Disease	BMI-adjusted waist circumference, physical activity measurement	FNDC3B PTCH1	3.44e-03	123	21	2	EFO_0007789, EFO_0008002
Disease	Acute Myeloid Leukemia, M1	KMT2C RASGRP1	3.55e-03	125	21	2	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	KMT2C RASGRP1	3.55e-03	125	21	2	C1879321
Disease	hip bone mineral density	ENTPD8 PTCH1	3.60e-03	126	21	2	EFO_0007702
Disease	allergic rhinitis	NFATC2 EYA2	4.00e-03	133	21	2	EFO_0005854
Disease	lung non-small cell carcinoma (is_implicated_in)	KMT2C KMT2D	4.36e-03	139	21	2	DOID:3908 (is_implicated_in)
Disease	Bladder Neoplasm	KMT2C KMT2D	4.42e-03	140	21	2	C0005695
Disease	Malignant neoplasm of urinary bladder	KMT2C KMT2D	4.49e-03	141	21	2	C0005684
Disease	stomach cancer (is_marker_for)	KMT2D PTCH1	4.55e-03	142	21	2	DOID:10534 (is_marker_for)
Disease	prostate cancer (is_marker_for)	KMT2C KMT2D	5.46e-03	156	21	2	DOID:10283 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSPLCHPAYADSVPT	BEGAIN	166	Q9BUH8
DTLYVLPSPTSPCPS	RASGRP1	701	O95267
LPYTPPSSESCHDGY	QSER1	1111	Q2KHR3
SHCSTYPEPIYPTLP	RFX6	676	Q8HWS3
PYYPQHPMVAESPSC	NFATC2	706	Q13469
SYHTYCLDPPLQTVP	KMT2C	1031	Q8NEZ4
PLYESPCVHATPPLS	ENTPD8	286	Q5MY95
CPASSPKVAYHPYPE	IRS2	616	Q9Y4H2
NSAECLHPPPSSVPY	CPHXL2	221	A0A1W2PPK0
PECYPPSYPSAMSPT	FNDC3B	106	Q53EP0
YNSAECLHPPPSSVP	CPHXL	246	A0A1W2PPM1
YTTLPYHLRSPCPSN	ADHFE1	251	Q8IWW8
SYNPPYVPASSICPS	EYA2	181	O00167
PYSPEYAPSPLHCSH	SOX7	241	Q9BT81
SHSPLYADPYTPPAT	PLEKHN1	451	Q494U1
TDTHDNTRYSPPPPY	PTCH1	631	Q13635
PPPSPSLHYSTLSCS	SHISA7	281	A6NL88
EPTPIPSYLITCYPF	SECISBP2L	46	Q93073
PHYFPSSTCPYSRPP	SOX30	621	O94993
SIVTSYPPPSYNPTC	ZFR2	181	Q9UPR6
QPSLSSCRHYMPPPY	RNF111	636	Q6ZNA4
APSPSLPPQCSYYTT	TNS4	31	Q8IZW8
SYHTYCLDPPLLTVP	KMT2D	1451	O14686