Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK5 GRIN2D

2.19e-0417262GO:0004970
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK5 GRIN2D

4.42e-0424262GO:0099507
GeneOntologyMolecularFunctionglutamate receptor activity

GRIK5 GRIN2D

5.61e-0427262GO:0008066
GeneOntologyMolecularFunctionglycolipid binding

CLIP3 CLN3

1.85e-0349262GO:0051861
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIK5 GRIN2D

2.49e-0357262GO:1904315
GeneOntologyMolecularFunctionprotein kinase A binding

NBEA LRBA

2.58e-0358262GO:0051018
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIK5 GRIN2D

2.75e-0360262GO:0099529
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIK5 GRIN2D

3.22e-0365262GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIK5 GRIN2D

3.22e-0365262GO:0022824
GeneOntologyBiologicalProcessionotropic glutamate receptor signaling pathway

GRIK5 GRIN2D CLN3

4.51e-0627253GO:0035235
GeneOntologyBiologicalProcessligand-gated ion channel signaling pathway

GRIK5 GRIN2D CLN3

1.51e-0540253GO:1990806
GeneOntologyBiologicalProcesscellular response to L-glutamate

GRIN2D AMIGO1

3.93e-058252GO:1905232
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRIK5 GRIN2D CLN3

4.89e-0559253GO:0007215
GeneOntologyBiologicalProcessregulation of protein localization to cell periphery

CLIP3 NBEA TMEM108 CLN3

5.04e-05171254GO:1904375
GeneOntologyBiologicalProcessregulation of protein localization to membrane

CLIP3 NBEA TMEM108 CLN3

1.78e-04237254GO:1905475
GeneOntologyBiologicalProcessresponse to L-glutamate

GRIN2D AMIGO1

2.13e-0418252GO:1902065
GeneOntologyBiologicalProcessregulation of neurotransmitter receptor localization to postsynaptic specialization membrane

NBEA TMEM108

4.16e-0425252GO:0098696
GeneOntologyBiologicalProcessmRNA modification

APOBEC1 PUS7

4.50e-0426252GO:0016556
GeneOntologyBiologicalProcessautophagosome organization

LRBA C9orf72 CLN3

4.97e-04129253GO:1905037
GeneOntologyBiologicalProcessexcitatory postsynaptic potential

TMEM108 GRIK5 GRIN2D

5.08e-04130253GO:0060079
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

GRIK5 GRIN2D CLN3

5.32e-04132253GO:0035249
GeneOntologyBiologicalProcessregulation of presynaptic membrane potential

GRIK5 GRIN2D

6.84e-0432252GO:0099505
GeneOntologyBiologicalProcesschemical synaptic transmission, postsynaptic

TMEM108 GRIK5 GRIN2D

7.27e-04147253GO:0099565
GeneOntologyBiologicalProcessregulation of protein localization to synapse

NBEA TMEM108

9.65e-0438252GO:1902473
GeneOntologyBiologicalProcessmacroautophagy

LRBA C9orf72 SPTLC2 CLN3

9.95e-04374254GO:0016236
GeneOntologyBiologicalProcessregulation of receptor localization to synapse

NBEA TMEM108

1.02e-0339252GO:1902683
GeneOntologyBiologicalProcesssynapse organization

MDGA2 NBEA TMEM108 CLN3 AMIGO1

1.22e-03685255GO:0050808
GeneOntologyBiologicalProcessregulation of postsynaptic membrane potential

TMEM108 GRIK5 GRIN2D

1.31e-03180253GO:0060078
GeneOntologyBiologicalProcessprotein localization to membrane

CLIP3 NBEA TMEM108 GRIK5 CLN3

1.38e-03705255GO:0072657
GeneOntologyBiologicalProcessregulation of macroautophagy

C9orf72 SPTLC2 CLN3

1.43e-03186253GO:0016241
GeneOntologyBiologicalProcessprotein localization to cell periphery

CLIP3 NBEA TMEM108 CLN3

1.55e-03422254GO:1990778
GeneOntologyBiologicalProcessneurotransmitter receptor localization to postsynaptic specialization membrane

NBEA TMEM108

1.60e-0349252GO:0099645
GeneOntologyBiologicalProcessprotein localization to postsynaptic specialization membrane

NBEA TMEM108

1.60e-0349252GO:0099633
GeneOntologyBiologicalProcesstransport along microtubule

CLIP3 TMEM108 CLN3

1.69e-03197253GO:0010970
GeneOntologyBiologicalProcesscell recognition

ACR SPON2 AMIGO1

1.71e-03198253GO:0008037
GeneOntologyCellularComponenthippocampal mossy fiber to CA3 synapse

GRIK5 GRIN2D C9orf72

7.76e-0567263GO:0098686
GeneOntologyCellularComponentglutamatergic synapse

MDGA2 NBEA TMEM108 GRIK5 GRIN2D C9orf72

4.12e-04817266GO:0098978
GeneOntologyCellularComponenttrans-Golgi network

CLIP3 NBEA LRBA CLN3

5.22e-04306264GO:0005802
GeneOntologyCellularComponentpostsynaptic density membrane

TMEM108 GRIK5 GRIN2D

9.52e-04157263GO:0098839
GeneOntologyCellularComponentionotropic glutamate receptor complex

GRIK5 GRIN2D

1.43e-0345262GO:0008328
GeneOntologyCellularComponentpostsynaptic membrane

NBEA TMEM108 GRIK5 GRIN2D

1.48e-03405264GO:0045211
GeneOntologyCellularComponentneurotransmitter receptor complex

GRIK5 GRIN2D

1.76e-0350262GO:0098878
GeneOntologyCellularComponentpostsynaptic specialization membrane

TMEM108 GRIK5 GRIN2D

1.93e-03201263GO:0099634
GeneOntologyCellularComponentGolgi apparatus subcompartment

CLIP3 NBEA LRBA CLN3

2.06e-03443264GO:0098791
GeneOntologyCellularComponentperikaryon

GRIK5 C9orf72 AMIGO1

2.60e-03223263GO:0043204
DomainDUF1088

NBEA LRBA

1.72e-062252PF06469
DomainDUF1088

NBEA LRBA

1.72e-062252IPR010508
DomainDUF4704

NBEA LRBA

1.72e-055252PF15787
DomainDUF4704

NBEA LRBA

1.72e-055252IPR031570
DomainPH_BEACH

NBEA LRBA

2.57e-056252PF14844
DomainPH-BEACH_dom

NBEA LRBA

4.79e-058252IPR023362
DomainPH_BEACH

NBEA LRBA

4.79e-058252PS51783
Domain-

NBEA LRBA

4.79e-0582522.30.29.40
DomainBeach

NBEA LRBA

6.16e-059252PF02138
Domain-

NBEA LRBA

6.16e-0592521.10.1540.10
DomainBEACH_dom

NBEA LRBA

6.16e-059252IPR000409
DomainBeach

NBEA LRBA

6.16e-059252SM01026
DomainBEACH

NBEA LRBA

6.16e-059252PS50197
Domainig

OBSCN MDGA2 PTGFRN AMIGO1

1.11e-04190254PF00047
DomainImmunoglobulin

OBSCN MDGA2 PTGFRN AMIGO1

1.11e-04190254IPR013151
DomainIontro_rcpt

GRIK5 GRIN2D

2.60e-0418252IPR001320
DomainLig_chan

GRIK5 GRIN2D

2.60e-0418252PF00060
DomainLig_chan-Glu_bd

GRIK5 GRIN2D

2.60e-0418252PF10613
DomainPBPe

GRIK5 GRIN2D

2.60e-0418252SM00079
DomainIono_rcpt_met

GRIK5 GRIN2D

2.60e-0418252IPR001508
DomainGlu/Gly-bd

GRIK5 GRIN2D

2.60e-0418252IPR019594
DomainLig_chan-Glu_bd

GRIK5 GRIN2D

2.60e-0418252SM00918
DomainANF_receptor

GRIK5 GRIN2D

1.11e-0337252PF01094
DomainANF_lig-bd_rcpt

GRIK5 GRIN2D

1.11e-0337252IPR001828
DomainPeripla_BP_I

GRIK5 GRIN2D

1.24e-0339252IPR028082
DomainIg_I-set

OBSCN MDGA2 AMIGO1

2.02e-03190253IPR013098
DomainI-set

OBSCN MDGA2 AMIGO1

2.02e-03190253PF07679
DomainIG

OBSCN MDGA2 PTGFRN AMIGO1

2.21e-03421254SM00409
DomainIg_sub

OBSCN MDGA2 PTGFRN AMIGO1

2.21e-03421254IPR003599
DomainIg_V-set

OBSCN PTGFRN AMIGO1

2.31e-03199253IPR013106
DomainConA-like_dom

MDGA2 NBEA LRBA

3.02e-03219253IPR013320
DomainIG_LIKE

OBSCN MDGA2 PTGFRN AMIGO1

3.85e-03491254PS50835
DomainIg-like_dom

OBSCN MDGA2 PTGFRN AMIGO1

4.20e-03503254IPR007110
DomainIGv

OBSCN PTGFRN

4.50e-0375252SM00406
DomainARM-like

PKP1 NBEA LRBA

5.43e-03270253IPR011989
Domain-

NBEA LRBA

7.12e-03952522.60.120.200
DomainARM-type_fold

PKP1 NBEA LRBA

1.01e-02339253IPR016024
Domain-

OBSCN MDGA2 PTGFRN AMIGO1

1.10e-026632542.60.40.10
DomainIg-like_fold

OBSCN MDGA2 PTGFRN AMIGO1

1.36e-02706254IPR013783
Pubmed

The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.

NBEA LRBA

1.61e-06326228814779
Pubmed

BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function.

NBEA LRBA

5.37e-06526212160729
Pubmed

An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan.

NBEA LRBA

8.05e-06626219482073
Pubmed

Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.

GRIK5 GRIN2D

1.50e-05826219125103
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ENDOD1 PTGFRN SPTLC2 PUS7 AMIGO1

2.88e-0549326515368895
Pubmed

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.

NBEA PUS7

8.16e-051826227984743
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIK5 GRIN2D

1.47e-042426235746896
Pubmed

Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses.

NBEA LRBA

1.86e-042726219723784
Pubmed

Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer.

TMEM108 SPTLC2

2.01e-042826225356737
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

OBSCN PTGFRN AMIGO1

2.38e-0416226325826454
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

NBEA PUS7

2.47e-043126225838543
Pubmed

Expression profiles and pathway analysis in HEK 293 T cells overexpressing HIV-1 Tat and nucleocapsid using cDNA microarray.

APOBEC1 BRPF1

4.12e-044026218051367
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA LRBA

2.63e-0591621230
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

OBSCN MDGA2

8.71e-03161162593
GeneFamilyAdenosine receptors|V-set domain containing

PTGFRN AMIGO1

8.92e-03163162590
GeneFamilyImmunoglobulin like domain containing

MDGA2 PTGFRN

1.23e-02193162594
GeneFamilyWD repeat domain containing

NBEA LRBA

2.20e-02262162362
DrugGAMs

GRIK5 GRIN2D ACR

1.09e-0538263CID000002935
Diseaselifestyle measurement, alcohol consumption measurement

GRIK5 LRBA SPON2

1.25e-04115253EFO_0007878, EFO_0010724
Diseaseautism spectrum disorder (implicated_via_orthology)

PKP1 NBEA LRBA

2.84e-04152253DOID:0060041 (implicated_via_orthology)
Diseasebipolar disorder, body mass index

CLN3 PUS7

1.70e-0372252EFO_0004340, MONDO_0004985
DiseaseR-6-hydroxywarfarin measurement

LRBA PUS7

4.19e-03114252EFO_0803327
Diseasestroke outcome severity measurement

MDGA2 GRIK5

4.19e-03114252EFO_0009603
Diseasecigarettes per day measurement

MDGA2 LRBA CLN3

5.86e-03438253EFO_0006525
Diseaselifestyle measurement, anxiety disorder measurement

GRIK5 LRBA

5.99e-03137252EFO_0007795, EFO_0010724
DiseaseIntellectual Disability

NBEA GRIN2D PUS7

6.20e-03447253C3714756
Diseaseclostridium difficile infection

GRIK5 LRBA

6.59e-03144252EFO_0009130

Protein segments in the cluster

PeptideGeneStartEntry
QLFSHWQYRQLSSVM

AMIGO1

231

Q86WK6
DYIEHGWQSYTMRQR

ERVK13-1

116

Q9NX77
IQIMRASEYYHCWRN

APOBEC1

141

P41238
WMVSLQIFTYNSHRY

ACR

56

P10323
QNWSLQDHYRMYSPI

CCDC14

191

Q49A88
MTQSFQERWYVNLHS

ENDOD1

166

O94919
MTQRWQHREISNFEY

LRBA

2211

P50851
NIYADNQVMHFYRWL

POLE

1811

Q07864
NRHRVYSYSLQWTQM

MDGA2

646

Q7Z553
YLWQMLSATQYLHNQ

OBSCN

7771

Q5VST9
RMYHSWQVERDTYQQ

GLT1D1

321

Q96MS3
RSRWTNMNALHYAAY

CLIP3

156

Q96DZ5
TFFQNSRYQTYQRMW

GRIK5

676

Q16478
SRYQTYQRMWNYMQS

GRIK5

681

Q16478
WYKGVTYRLTHQNMN

C5orf34

336

Q96MH7
YNQRRYMRSELTAFW

C9orf72

326

Q96LT7
RFSSYSQMENWSRHY

PKP1

116

Q13835
SWYYRMNRRSDNVVT

PTGFRN

446

Q9P2B2
AHSSDYSMWRKNQYV

SPON2

76

Q9BUD6
YMISIVHIYNRWRNS

NBEA

326

Q8NFP9
NRLMYIHSYQSYVWN

PUS7

471

Q96PZ0
QRKSQFMQRLHSYWT

BRPF1

531

P55201
TSLSHAQQYRWYQML

CLN3

311

Q13286
FYTRNLYMRIRDNWN

SPTLC2

121

O15270
TQKVQNNIFHMWRYY

TMED6

166

Q8WW62
SYWNNTITMDYFNRH

TMEM108

506

Q6UXF1
HRYFMNITWDNRDYS

GRIN2D

361

O15399