Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	1.25e-06	5	101	3	GO:0030156
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA2 ATP13A2 ATP2C1 ABCB9 ATP2C2 ABCC2	1.92e-05	109	101	6	GO:0042626
GeneOntologyMolecularFunction	P-type manganese transporter activity	ATP2C1 ATP2C2	2.53e-05	2	101	2	GO:0140613
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCA2 ATP13A2 NDUFS1 ATP2C1 ABCB9 ATP2C2 ABCC2	3.38e-05	178	101	7	GO:0015399
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA2 RECQL MCM5 SRCAP ATP13A2 ATP2C1 ABCB9 ATP2C2 ABCC2 POLQ	7.98e-05	441	101	10	GO:0016887
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA2 ATP13A2 ABCB9 ABCC2	1.10e-04	49	101	4	GO:0140359
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA2 RECQL MCM5 SRCAP ATP13A2 ATP2C1 ABCB9 ATP2C2 KIFC3 ABCC2 POLQ	2.76e-04	614	101	11	GO:0140657
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ABCA2 RECQL MCM5 SRCAP ATP13A2 ARHGAP5 ATP2C1 ABCB9 MTIF2 ATP2C2 ABCC2 POLQ	5.40e-04	775	101	12	GO:0017111
GeneOntologyMolecularFunction	poly(U) RNA binding	PABPC1 PNPT1 PABPC3	6.71e-04	34	101	3	GO:0008266
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP13A2 ATP2C1 ATP2C2	7.94e-04	36	101	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP13A2 ATP2C1 ATP2C2	7.94e-04	36	101	3	GO:0015662
GeneOntologyMolecularFunction	poly-purine tract binding	PABPC1 PNPT1 PABPC3	8.61e-04	37	101	3	GO:0070717
GeneOntologyMolecularFunction	protein-glutamine gamma-glutamyltransferase activity	TGM6 F13A1	8.91e-04	9	101	2	GO:0003810
GeneOntologyMolecularFunction	poly-pyrimidine tract binding	PABPC1 PNPT1 PABPC3	1.01e-03	39	101	3	GO:0008187
GeneOntologyMolecularFunction	pyrophosphatase activity	ABCA2 RECQL MCM5 SRCAP ATP13A2 ARHGAP5 ATP2C1 ABCB9 MTIF2 ATP2C2 ABCC2 POLQ	1.08e-03	839	101	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ABCA2 RECQL MCM5 SRCAP ATP13A2 ARHGAP5 ATP2C1 ABCB9 MTIF2 ATP2C2 ABCC2 POLQ	1.09e-03	840	101	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ABCA2 RECQL MCM5 SRCAP ATP13A2 ARHGAP5 ATP2C1 ABCB9 MTIF2 ATP2C2 ABCC2 POLQ	1.09e-03	840	101	12	GO:0016818
GeneOntologyMolecularFunction	manganese ion transmembrane transporter activity	ATP2C1 ATP2C2	1.11e-03	10	101	2	GO:0005384
GeneOntologyMolecularFunction	P-type calcium transporter activity	ATP2C1 ATP2C2	1.35e-03	11	101	2	GO:0005388
GeneOntologyCellularComponent	mitochondrial intermembrane space	DUSP18 HTRA2 NDUFS1 PNPT1 PRELID3A HSD3B1	4.83e-06	88	103	6	GO:0005758
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C SPAG17 RIMBP3B	1.04e-05	28	103	4	GO:0002177
GeneOntologyCellularComponent	organelle envelope lumen	DUSP18 HTRA2 NDUFS1 PNPT1 PRELID3A HSD3B1	1.13e-05	102	103	6	GO:0031970
GeneOntologyCellularComponent	mCRD-mediated mRNA stability complex	PABPC1 PABPC3	3.56e-04	6	103	2	GO:0106002
Domain	P-type_ATPase_IIA_PMR1	ATP2C1 ATP2C2	2.67e-05	2	97	2	IPR006413
Domain	Cation_ATPase_N	ATP13A2 ATP2C1 ATP2C2	1.05e-04	18	97	3	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP13A2 ATP2C1 ATP2C2	1.24e-04	19	97	3	IPR004014
Domain	PolyA	PABPC1 PABPC3	2.64e-04	5	97	2	SM00517
Domain	-	PABPC1 PABPC3	2.64e-04	5	97	2	1.10.1900.10
Domain	PABP	PABPC1 PABPC3	2.64e-04	5	97	2	PF00658
Domain	PABP_1234	PABPC1 PABPC3	2.64e-04	5	97	2	IPR006515
Domain	PABC	PABPC1 PABPC3	2.64e-04	5	97	2	PS51309
Domain	PABP_HYD	PABPC1 PABPC3	2.64e-04	5	97	2	IPR002004
Domain	-	AP1G1 AP3B2	3.95e-04	6	97	2	2.60.40.1230
Domain	Clathrin_g-adaptin_app	AP1G1 AP3B2	3.95e-04	6	97	2	IPR008153
Domain	ATPase_P-typ_P_site	ATP13A2 ATP2C1 ATP2C2	8.56e-04	36	97	3	IPR018303
Domain	P_typ_ATPase	ATP13A2 ATP2C1 ATP2C2	8.56e-04	36	97	3	IPR001757
Domain	ATPASE_E1_E2	ATP13A2 ATP2C1 ATP2C2	8.56e-04	36	97	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP13A2 ATP2C1 ATP2C2	9.28e-04	37	97	3	IPR008250
Domain	E1-E2_ATPase	ATP13A2 ATP2C1 ATP2C2	9.28e-04	37	97	3	PF00122
Domain	Transglut_N	TGM6 F13A1	9.39e-04	9	97	2	PF00868
Domain	TRANSGLUTAMINASES	TGM6 F13A1	9.39e-04	9	97	2	PS00547
Domain	-	TGM6 F13A1	9.39e-04	9	97	2	3.90.260.10
Domain	Gln_gamma-glutamylTfrase_euk	TGM6 F13A1	9.39e-04	9	97	2	IPR023608
Domain	Transglutaminase_AS	TGM6 F13A1	9.39e-04	9	97	2	IPR013808
Domain	Transglutaminase_N	TGM6 F13A1	9.39e-04	9	97	2	IPR001102
Domain	Transglut_C	TGM6 F13A1	9.39e-04	9	97	2	PF00927
Domain	Transglutaminase_C	TGM6 F13A1	1.17e-03	10	97	2	IPR008958
Domain	ABC_transporter_CS	ABCA2 ABCB9 ABCC2	1.35e-03	42	97	3	IPR017871
Domain	Filamin	MYCBP2 TRIM71	1.42e-03	11	97	2	PF00630
Domain	Transglutaminase-like	TGM6 F13A1	1.42e-03	11	97	2	IPR002931
Domain	FILAMIN_REPEAT	MYCBP2 TRIM71	1.42e-03	11	97	2	PS50194
Domain	Filamin/ABP280_rpt	MYCBP2 TRIM71	1.42e-03	11	97	2	IPR001298
Domain	Filamin/ABP280_repeat-like	MYCBP2 TRIM71	1.42e-03	11	97	2	IPR017868
Domain	TGc	TGM6 F13A1	1.42e-03	11	97	2	SM00460
Domain	Transglut_core	TGM6 F13A1	1.42e-03	11	97	2	PF01841
Domain	P-loop_NTPase	ABCA2 RECQL MCM5 SRCAP ARHGAP5 LRRIQ1 ABCB9 SBNO1 MTIF2 KIFC3 ABCC2 POLQ	1.46e-03	848	97	12	IPR027417
Domain	Coatomer/clathrin_app_Ig-like	AP1G1 AP3B2	1.70e-03	12	97	2	IPR013041
Domain	ARM-type_fold	APOB TRRAP MAP3K1 RYR3 SCYL2 AP1G1 AP3B2	1.94e-03	339	97	7	IPR016024
Domain	ABC_tran	ABCA2 ABCB9 ABCC2	1.98e-03	48	97	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA2 ABCB9 ABCC2	1.98e-03	48	97	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA2 ABCB9 ABCC2	2.10e-03	49	97	3	PS00211
Domain	Ig_E-set	MYCBP2 TRIM71 TGM6 F13A1	2.11e-03	104	97	4	IPR014756
Domain	ABC_transporter-like	ABCA2 ABCB9 ABCC2	2.23e-03	50	97	3	IPR003439
Domain	-	MAG SDK2 MYCBP2 TRIM71 TGM6 LRIT3 F13A1 RIMBP3 RIMBP3C RIMBP3B	2.32e-03	663	97	10	2.60.40.10
Domain	Clathrin/coatomer_adapt-like_N	AP1G1 AP3B2	2.68e-03	15	97	2	IPR002553
Domain	Adaptin_N	AP1G1 AP3B2	2.68e-03	15	97	2	PF01602
Domain	ATPase_P-typ_TM_dom	ATP2C1 ATP2C2	3.06e-03	16	97	2	IPR023298
Domain	-	ATP2C1 ATP2C2	3.06e-03	16	97	2	1.20.1110.10
Domain	ATPase_P-typ_cation-transptr_C	ATP2C1 ATP2C2	3.45e-03	17	97	2	IPR006068
Domain	Cation_ATPase_C	ATP2C1 ATP2C2	3.45e-03	17	97	2	PF00689
Domain	Acyl_Trfase/lysoPLipase	FASN PNPLA8	3.45e-03	17	97	2	IPR016035
Domain	Ig-like_fold	MAG SDK2 MYCBP2 TRIM71 TGM6 LRIT3 F13A1 RIMBP3 RIMBP3C RIMBP3B	3.64e-03	706	97	10	IPR013783
Domain	FN3	SDK2 LRIT3 RIMBP3 RIMBP3C RIMBP3B	3.81e-03	199	97	5	PS50853
Domain	Cation_ATPase_N	ATP2C1 ATP2C2	3.87e-03	18	97	2	PF00690
Domain	FN3_dom	SDK2 LRIT3 RIMBP3 RIMBP3C RIMBP3B	4.69e-03	209	97	5	IPR003961
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.04e-07	4	104	3	19091768
Pubmed	Functional cloning of genes that suppress oxidative stress-induced cell death: TCTP prevents hydrogen peroxide-induced cell death.	TPT1 PABPC1 PABPC3	1.04e-07	4	104	3	19328788
Pubmed	Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.	RIOX1 TRRAP SBNO1	2.59e-07	5	104	3	17308053
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	2.59e-07	5	104	3	17855024
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TPT1 KRT12 CFL2 CCDC150 MCM5 APOB SRCAP PABPC1 NDUFS1 OR10G4 FASN ABCB9 SBNO1 PABPC3 ABCC2 SPAG17 POLQ	1.30e-06	1442	104	17	35575683
Pubmed	Secretory pathway Ca2+ -ATPases promote in vitro microcalcifications in breast cancer cells.	ATP2C1 ATP2C2	8.86e-06	2	104	2	28618103
Pubmed	Factor XIII A subunit Val34Leu polymorphism in patients suffering atherothrombotic ischemic stroke.	F8 F13A1	8.86e-06	2	104	2	20609463
Pubmed	The promoter of the Poly(A) binding protein 2 (Pabp2) retroposon is derived from the 5'-untranslated region of the Pabp1 progenitor gene.	PABPC1 PABPC3	8.86e-06	2	104	2	10534404
Pubmed	Factor XIII Val34Leu variant protects against coronary artery disease. A meta-analysis.	F8 F13A1	8.86e-06	2	104	2	17334514
Pubmed	Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses.	ATP2C1 ATP2C2	8.86e-06	2	104	2	16332677
Pubmed	Nucleotide sequence of a mouse testis poly(A) binding protein cDNA.	PABPC1 PABPC3	8.86e-06	2	104	2	1630930
Pubmed	Developmental expression of poly(A) binding protein mRNAs during spermatogenesis in the mouse.	PABPC1 PABPC3	8.86e-06	2	104	2	7893484
Pubmed	Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.	PABPC1 PABPC3	8.86e-06	2	104	2	19020299
Pubmed	Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.	PABPC1 PABPC3	8.86e-06	2	104	2	26971890
Pubmed	Levels of free PABP are limited by newly polyadenylated mRNA in early Spisula embryogenesis.	PABPC1 PABPC3	8.86e-06	2	104	2	10954604
Pubmed	Alginate oligosaccharide protects endothelial cells against oxidative stress injury via integrin-α/FAK/PI3K signaling.	ITGA1 PTK2	8.86e-06	2	104	2	32986180
Pubmed	The mouse gene encoding the testis-specific isoform of Poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes.	PABPC1 PABPC3	8.86e-06	2	104	2	9732454
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	9.23e-06	14	104	3	17662146
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FAM120B LRWD1 MYCBP2 ACOT7 RECQL MCM5 SRCAP TRRAP PABPC1 NDUFS1 PTK2 FASN GTF2H4 AP1G1 ZNF638	1.21e-05	1353	104	15	29467282
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	MYCBP2 MCM5 PABPC1 SCYL2 FASN PABPC3	1.50e-05	175	104	6	25756610
Pubmed	Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.	APOB GCKR AP3B2	2.43e-05	19	104	3	23118302
Pubmed	STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.	CUL4A AIMP1 RECQL PABPC1 NDUFS1 MAP3K1	2.54e-05	192	104	6	32176739
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCA2 LRWD1 MYCBP2 HECTD4 EML2 MCM5 SRCAP TRRAP ATP13A2 FASN KIFC3 MBD5 TTC5	2.64e-05	1105	104	13	35748872
Pubmed	MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression.	PTK2 MAP3K1	2.65e-05	3	104	2	12458213
Pubmed	Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence.	PABPC1 PABPC3	2.65e-05	3	104	2	26134869
Pubmed	Human testis expresses a specific poly(A)-binding protein.	PABPC1 PABPC3	2.65e-05	3	104	2	11328870
Pubmed	Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos.	PABPC1 PABPC3	2.65e-05	3	104	2	25034140
Pubmed	SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport.	PABPC1 PABPC3	2.65e-05	3	104	2	28756945
Pubmed	The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.	PABPC1 PABPC3	2.65e-05	3	104	2	26843391
Pubmed	Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.	PTK2 PAK1	2.65e-05	3	104	2	27542844
Pubmed	Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs.	PABPC1 PABPC3	2.65e-05	3	104	2	21940797
Pubmed	The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs.	PABPC1 PABPC3	2.65e-05	3	104	2	10076007
Pubmed	Epab and Pabpc1 are differentially expressed during male germ cell development.	PABPC1 PABPC3	2.65e-05	3	104	2	22814100
Pubmed	De novo variants in the PABP domain of PABPC1 lead to developmental delay.	PABPC1 PABPC3	2.65e-05	3	104	2	35511136
Pubmed	Epab is dispensable for mouse spermatogenesis and male fertility.	PABPC1 PABPC3	2.65e-05	3	104	2	24599567
Pubmed	Differential 3' Processing of Specific Transcripts Expands Regulatory and Protein Diversity Across Neuronal Cell Types.	PABPC1 PABPC3	2.65e-05	3	104	2	29578408
Pubmed	FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.	PTK2 MAP3K1	2.65e-05	3	104	2	17409352
Pubmed	Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs.	PABPC1 PABPC3	2.65e-05	3	104	2	29701755
Pubmed	Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response.	PABPC1 PABPC3	2.65e-05	3	104	2	28635594
Pubmed	Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke.	F8 F13A1	2.65e-05	3	104	2	17927806
Pubmed	Epab and Pabpc1 are differentially expressed in the postnatal mouse ovaries.	PABPC1 PABPC3	2.65e-05	3	104	2	25370180
Pubmed	Store-independent activation of Orai1 by SPCA2 in mammary tumors.	ATP2C1 ATP2C2	2.65e-05	3	104	2	20887894
Pubmed	Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.	PABPC1 PABPC3	2.65e-05	3	104	2	28611064
Pubmed	A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway.	PABPC1 PABPC3	2.65e-05	3	104	2	37665675
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYCBP2 RECQL MCM5 TRRAP PABPC1 NDUFS1 PPM1G PNPT1 FASN ZNF638	2.72e-05	653	104	10	22586326
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ABCA2 MYCBP2 HECTD4 ARMCX4 PTK2 RYR3 SCYL2 ARHGAP5 SBNO1 MTIF2 PAK1 CCDC15 ZNF76 KIFC3	2.95e-05	1285	104	14	35914814
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	TPT1 FLOT2 AIMP1 CFL2 MCM5 SRCAP PABPC1 PPM1G PABPC3 AP3B2 UBFD1	4.77e-05	847	104	11	35235311
Pubmed	Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.	PABPC1 PABPC3	5.29e-05	4	104	2	16804161
Pubmed	Orc2 protects ORCA from ubiquitin-mediated degradation.	CUL4A LRWD1	5.29e-05	4	104	2	22935713
Pubmed	Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.	PABPC1 PABPC3	5.29e-05	4	104	2	18490513
Pubmed	Stress granules inhibit apoptosis by reducing reactive oxygen species production.	PABPC1 PABPC3	5.29e-05	4	104	2	23230274
Pubmed	Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.	TGM6 F13A1	5.29e-05	4	104	2	21939789
Pubmed	Transthyretin Upregulates Long Non-Coding RNA MEG3 by Affecting PABPC1 in Diabetic Retinopathy.	PABPC1 PABPC3	5.29e-05	4	104	2	31847264
Pubmed	RNA-binding proteins in mouse oocytes and embryos: expression of genes encoding Y box, DEAD box RNA helicase, and polyA binding proteins.	PABPC1 PABPC3	5.29e-05	4	104	2	9883581
Pubmed	Lack of association between FXIII-Val34Leu, FVII-323 del/ins, and transforming growth factor beta1 (915G/T) gene polymorphisms and bronchopulmonary dysplasia: a single-center study.	F8 F13A1	5.29e-05	4	104	2	19778283
Pubmed	Evolution of complexity in the zebrafish synapse proteome.	PABPC1 PABPC3	5.29e-05	4	104	2	28252024
Pubmed	SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry in a model of lactation.	ATP2C1 ATP2C2	5.29e-05	4	104	2	23840669
Pubmed	An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.	PABPC1 PABPC3	5.29e-05	4	104	2	15630085
Pubmed	UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.	PABPC1 PABPC3	5.29e-05	4	104	2	15314026
Pubmed	Factor XIII activity mediates red blood cell retention in venous thrombi.	F8 F13A1	5.29e-05	4	104	2	24983320
Pubmed	P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.	PTK2 PAK1	5.29e-05	4	104	2	20811717
Pubmed	The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.	MYCBP2 ATP13A2	5.29e-05	4	104	2	27278822
Pubmed	Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.	PABPC1 PABPC3	5.29e-05	4	104	2	24129315
Pubmed	cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.	PABPC1 PABPC3	5.29e-05	4	104	2	28910620
Pubmed	ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.	PABPC1 PABPC3	5.29e-05	4	104	2	22956915
Pubmed	HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.	PABPC1 PABPC3	8.80e-05	5	104	2	19956697
Pubmed	AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis.	PABPC1 PABPC3	8.80e-05	5	104	2	24648398
Pubmed	MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty.	PABPC1 PABPC3	8.80e-05	5	104	2	33744966
Pubmed	Interaction of HuDA and PABP at 5'UTR of mouse insulin2 regulates insulin biosynthesis.	PABPC1 PABPC3	8.80e-05	5	104	2	29590218
Pubmed	Poly(A) tail length regulates PABPC1 expression to tune translation in the heart.	PABPC1 PABPC3	8.80e-05	5	104	2	28653618
Pubmed	Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice.	PABPC1 PABPC3	8.80e-05	5	104	2	26492470
Pubmed	Isolation of cDNAs from a mouse astroglial cell line by a subtracted cDNA library.	PABPC1 PABPC3	8.80e-05	5	104	2	1701491
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	ABCA2 APOB GCKR	8.97e-05	29	104	3	20167577
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FLOT2 DUSP18 FAM120B MYCBP2 HECTD4 TRIM71 SRCAP TRRAP NDUFS1 PNPT1 ZNF638 PROX1	9.65e-05	1082	104	12	38697112
Pubmed	Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.	PTK2 ARHGAP5 PAK1	9.94e-05	30	104	3	24472646
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	TPT1 FLOT2 CFL2 ATP13A2 PABPC1 NDUFS1 ATP2C1 ABCB9 ZNF638 KIFC3 UBFD1	1.04e-04	925	104	11	28986522
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	MAG TRRAP PABPC1 NDUFS1 PTK2 FASN AP1G1 PABPC3 AP3B2	1.06e-04	621	104	9	22794259
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PLIN4 MCM5 ITGA1 PABPC1 NDUFS1 F13A1 FABP4 PNPT1 FASN AKAP9 AP1G1 MTIF2 PABPC3 KIFC3	1.08e-04	1451	104	14	30550785
Pubmed	Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.	PTK2 PAK1	1.32e-04	6	104	2	25456130
Pubmed	Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.	PABPC1 PABPC3	1.32e-04	6	104	2	17927953
Pubmed	Translation of insulin granule proteins are regulated by PDI and PABP.	PABPC1 PABPC3	1.32e-04	6	104	2	32248978
Pubmed	MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival.	CUL4A MAP3K1	1.32e-04	6	104	2	34251884
Pubmed	The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics.	PTK2 PAK1	1.32e-04	6	104	2	18086875
Pubmed	Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation.	MAP3K1 PAK1	1.32e-04	6	104	2	12228228
Pubmed	The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.	PABPC1 PABPC3	1.32e-04	6	104	2	10358005
Pubmed	Embryonic poly(A)-binding protein is differently expressed and interacts with the messenger RNAs in the mouse oocytes and early embryos.	PABPC1 PABPC3	1.32e-04	6	104	2	30302808
Pubmed	Expression of genes involved in mammalian meiosis during the transition from egg to embryo.	MCM5 PABPC1 PABPC3	1.33e-04	33	104	3	11389549
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	TPT1 ABCA2 MYCBP2 ACOT7 SRCAP PABPC1 FASN AKAP9 AP1G1 SPAG17	1.57e-04	807	104	10	30575818
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	FAT4 ABCA2 MCM5 APOB NDUFS1 AP3B2 SPAG17 TTC33	1.58e-04	513	104	8	25798074
Pubmed	Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.	APOB GCKR	1.84e-04	7	104	2	20657596
Pubmed	Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.	FAT4 FAT3	1.84e-04	7	104	2	22510986
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	FAT4 FAT3	1.84e-04	7	104	2	16059920
Pubmed	E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.	PABPC1 PABPC3	1.84e-04	7	104	2	34143182
Pubmed	Genetic imbalances in preleukemic thymuses.	PABPC1 PABPC3	1.84e-04	7	104	2	11322760
Pubmed	Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes.	PABPC1 PABPC3	1.84e-04	7	104	2	10543404
Pubmed	NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.	PABPC1 PABPC3	1.84e-04	7	104	2	34784943
Pubmed	Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.	MAG PAK1	1.84e-04	7	104	2	27583434
Pubmed	A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells.	PTK2 PAK1	2.45e-04	8	104	2	15673687
Pubmed	An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line.	KRT12 MAP3K1	2.45e-04	8	104	2	34078823
Pubmed	Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.	PABPC1 PABPC3	2.45e-04	8	104	2	21262862
Interaction	LINC01588 interactions	FAT4 FAT3 PPM1G TTC5	3.90e-06	22	100	4	int:LINC01588
GeneFamily	Transglutaminases	TGM6 F13A1	6.16e-04	9	76	2	773
GeneFamily	ATPases Ca2+ transporting	ATP2C1 ATP2C2	6.16e-04	9	76	2	1209
GeneFamily	Parkinson disease associated genes	HTRA2 ATP13A2	2.01e-03	16	76	2	672
GeneFamily	Cadherin related	FAT4 FAT3	2.28e-03	17	76	2	24
ToppCell	droplet-Marrow-BM-30m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA2 ACOT7 ITGA1 F13A1 FASN UBFD1	5.31e-06	188	104	6	bf77e59b9001c7f7ca17f81073f935f281a25a1f
ToppCell	droplet-Marrow-BM-30m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA2 ACOT7 ITGA1 F13A1 FASN UBFD1	5.31e-06	188	104	6	b2472a294b25fc2f0da7f18519fdcb9ca166c6f0
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2C1 ATP2C2	1.59e-04	6	97	2	DOID:0050429 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	ZNF569 CFL2 RECQL PKDREJ PABPC1 MAP3K1 FABP4 FASN AKAP9 SBNO1 PAK1 CDH10	2.10e-04	1074	97	12	C0006142
Disease	Squamous cell carcinoma of esophagus	FAT4 FAT3 FASN ABCC2	2.78e-04	95	97	4	C0279626
Disease	lipoprotein-associated phospholipase A(2) measurement	APOB GCKR AP3B2	3.11e-04	40	97	3	EFO_0004746
Disease	Thrombophilia	F8 F13A1	3.79e-04	9	97	2	C0398623
Disease	cortical surface area measurement	MYCBP2 FAT3 EML2 TRIM71 MND1 ACVR2A ATP13A2 MAP3K1 LRRIQ1 ELF2 SPAG17 PTPN20 PDZD2	4.58e-04	1345	97	13	EFO_0010736
Disease	level of Triacylglycerol (51:3) in blood serum	APOB GCKR	4.73e-04	10	97	2	OBA_2045163
Disease	phospholipids in medium LDL measurement	APOB GCKR ITGA1	5.69e-04	49	97	3	EFO_0022183
Disease	level of Diacylglycerol (18:1_18:1) in blood serum	APOB GCKR	5.77e-04	11	97	2	OBA_2045170
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	APOB GCKR PPM1G	6.40e-04	51	97	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	total lipids in LDL measurement	APOB GCKR ITGA1	6.77e-04	52	97	3	EFO_0022308
Disease	phosphatidylcholine 34:4 measurement	GCKR MBD5	6.91e-04	12	97	2	EFO_0010378
Disease	alcohol consumption measurement, alcohol drinking	HECTD4 GCKR	6.91e-04	12	97	2	EFO_0004329, EFO_0007878
Disease	phospholipids in large LDL measurement	APOB GCKR ITGA1	7.16e-04	53	97	3	EFO_0022174
Disease	total lipids in large LDL	APOB GCKR ITGA1	8.86e-04	57	97	3	EFO_0022163
Disease	cholesterol in large LDL measurement	APOB GCKR ITGA1	8.86e-04	57	97	3	EFO_0021901
Disease	phospholipids in LDL measurement	APOB GCKR ITGA1	9.32e-04	58	97	3	EFO_0022294
Disease	phospholipids in small LDL measurement	APOB GCKR ITGA1	9.80e-04	59	97	3	EFO_0022297
Disease	triacylglycerol 52:3 measurement	APOB GCKR	1.09e-03	15	97	2	EFO_0010415
Disease	glycerate measurement	RYR3 SLC23A1	1.09e-03	15	97	2	EFO_0021029
Disease	Hypertriglyceridemia	APOB GCKR	1.09e-03	15	97	2	C0020557
Disease	diacylglycerol 44:7 measurement	GCKR PPM1G	1.25e-03	16	97	2	EFO_0020069
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	APOB GCKR PPM1G	1.54e-03	69	97	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	obsolete_red blood cell distribution width	DAGLB CUL4A MAG AVL9 HECTD4 APOB GCKR F8 PTK2 MAP3K1 ZNF611 SLC23A1	1.55e-03	1347	97	12	EFO_0005192
Disease	Paroxysmal atrial fibrillation	CUL4A CFL2 PTK2 MBD5	1.78e-03	156	97	4	C0235480
Disease	familial atrial fibrillation	CUL4A CFL2 PTK2 MBD5	1.78e-03	156	97	4	C3468561
Disease	Persistent atrial fibrillation	CUL4A CFL2 PTK2 MBD5	1.78e-03	156	97	4	C2585653
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	HECTD4 APOB GCKR ITGA1 TAF11	1.82e-03	264	97	5	EFO_0008317, EFO_0020944
Disease	Atrial Fibrillation	CUL4A CFL2 PTK2 MBD5	1.95e-03	160	97	4	C0004238
Disease	Deep Vein Thrombosis	F8 F13A1	2.16e-03	21	97	2	C0149871
Disease	Venous Thrombosis	F8 F13A1	2.16e-03	21	97	2	C0042487
Disease	Parkinson disease	HTRA2 ATP13A2	2.37e-03	22	97	2	cv:C0030567
Disease	alcohol drinking	FAT3 HECTD4 GCKR	2.44e-03	81	97	3	EFO_0004329
Disease	reticulocyte measurement	CUL4A FLOT2 HECTD4 GCKR ITGA1 MND1 PABPC1 MAP3K1 SLC23A1 PDZD2	2.44e-03	1053	97	10	EFO_0010700
Disease	Hypertrophic obstructive cardiomyopathy	NDUFS1 FASN	3.05e-03	25	97	2	C4551472
Disease	fasting blood glucose measurement, HOMA-B, fasting blood insulin measurement	GCKR PROX1	3.05e-03	25	97	2	EFO_0004465, EFO_0004466, EFO_0004469

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSKHSVEVQVNVMSE	ACOT7	131	O00154
KVIVSMSIAFAQQTE	AKAP9	1446	Q99996
VTHRESIMNVNVKGT	HSD3B1	91	P14060
KANMVATSTAVISGV	APOL6	76	Q9BWW8
MVSENVIQSTAVTTV	AIMP1	91	Q12904
TEDIVTVVTMVTNVD	ACVR2A	491	P27037
ALTVTGVAQVKIMTE	FLOT2	66	Q14254
GTVTGDTMVNITVKD	FAT4	871	Q6V0I7
NGSTVKMETVVGVQS	ARMCX4	41	Q5H9R4
KMETVVGVQSQTLAI	ARMCX4	46	Q5H9R4
ESKVVAGTLVMTEAV	ARMCX4	116	Q5H9R4
IKMITGDSQETAVAI	ATP2C1	566	P98194
VQVLSESGVSVKMIT	ATP2C2	586	O75185
AAQLTVNSEKMVIGT	AP3B2	1056	Q13367
QMVRVGSKTEVATEI	RIMBP3B	946	A6NNM3
QMVRVGSKTEVATEI	RIMBP3C	946	A6NJZ7
ATKAVTEMNGRIVAT	PABPC1	346	P11940
LGQVVTKTMVNTVVA	LRWD1	611	Q9UFC0
VMEKVTTNGPTEIVQ	AP1G1	586	O43747
AVASKVQTAVTMKGV	CHMP1A	71	Q9HD42
TSANVMVIFVDIGIV	OR10G4	191	Q8NGN3
ADISVNVISMGVTNV	OR13C7	191	P0DN81
HMAVVELVVGNTQAT	OR52W1	186	Q6IF63
AQTVAEQVEMKAKVV	TRIM71	346	Q2Q1W2
VIVEMNSSVEAIEGS	MAG	241	P20916
KTVVQEMVNGEVVSS	KRT12	471	Q99456
VLVVAADDGVMKQTV	MTIF2	256	P46199
AMEQQTISIAKAGIT	MCM5	461	P33992
MASGVTVNDEVIKVF	CFL2	1	Q9Y281
GITAMSVKEVLQSLV	MND1	41	Q9BWT6
SATGMVQLVVASKEN	PDZD2	406	O15018
KVRGTQVVGSDMTVT	F13A1	636	P00488
QVVGSDMTVTVEFTN	F13A1	641	P00488
TVGETVNLMSVDAQK	ABCC2	416	Q92887
VDFQKTMKVTGVTTQ	F8	2251	P00451
KNLAGMSEAVVTVTV	LRIT3	331	Q3SXY7
VEQVQEAFGETMTSV	HECTD4	1241	Q9Y4D8
VTEVKENMTFGSTLV	ITGA1	106	P56199
VIFNTTDTMINIEGK	LRRIQ1	656	Q96JM4
ATKAVTEMNGRIVAT	PABPC3	346	Q9H361
SESILTTMVQVAGKV	GCKR	76	Q14397
IIRMFQVVEKSTGTS	PTPN20	296	Q4JDL3
TAMDVATGQEVAIKQ	PAK1	286	Q13153
VTQAEGAKQTEATMT	APOB	1036	P04114
AVMVTGDNLQTAVTV	ATP13A2	746	Q9NQ11
EVIGVNTMKVTAGIS	HTRA2	316	O43464
IQEMGSTVEVERKQV	CCDC150	241	Q8NCX0
EMSVVGTSVVQVTAT	CDH10	171	Q9Y6N8
KESVVVAVRGTMSLQ	DAGLB	366	Q8NCG7
KIGNVMVTTSRNVVQ	AVL9	591	Q8NBF6
MVTTSRNVVQTGKAV	AVL9	596	Q8NBF6
QIQMKETVEEQVSTT	CUL4A	671	Q13619
VVQVAQIVKNEMESA	POLQ	2551	O75417
MSVEVTDGTNVAVTQ	FAT3	1431	Q8TDW7
SLAQVFSKMEQVSGV	ABCA2	2326	Q9BZC7
VVMTSLGQKISTVAV	ELF2	396	Q15723
AVVDAASKGMQVVIT	MBD5	1091	Q9P267
ASKGMQVVITTAVNS	MBD5	1096	Q9P267
DMVTIATGQVAGTTK	EML2	116	O95834
MIISVNGDVITIKSE	FABP4	41	P15090
VGILVETMSTNDTIV	FASN	2066	P49327
IEVAAMTSKGQGQVS	SDK2	966	Q58EX2
VLASVSGTNVKMQIV	SBNO1	1321	A3KN83
QQVTMVSDTEILKVA	FAM120B	566	Q96EK7
MSGENVTKVSTFILV	OR6B2	1	Q6IFH4
QDVGTGTLMAVKQVT	MAP3K1	1261	Q13233
SDVFSQNVIVGTVKM	PNPLA8	511	Q9NP80
MNVAKGTIQTGVDTT	PLIN4	331	Q96Q06
MGAVNVAKGTVQTSV	PLIN4	691	Q96Q06
IDVMDAVGSNIVVST	NDUFS1	251	P28331
QMVRVGSKTEVATEI	RIMBP3	946	Q9UFD9
VSQNVVIAMSGISKV	TAF11	146	Q15544
MVVQVSPVEKNTSET	KIFC3	741	Q9BVG8
VSTLVEIGQVVMTIT	PKDREJ	746	Q9NTG1
ENVTGLVKAVIEMSS	PTK2	926	Q05397
LNTAMSQVVDTVVKV	PROX1	356	Q92786
VMSSQEVVDFIQSKI	PPM1G	446	O15355
TNAAVGDMVTVVKTE	PRDM11	46	Q9NQV5
MTVLTQEAIITVKGI	PRELID3A	121	Q96N28
TVTKVTADVTSAVMG	SCYL2	11	Q6P3W7
GVASTEEETQAVMKV	MYCBP2	1211	O75592
VSMEVTVNAVAGALK	ARHGAP5	1321	Q13017
TMVNNTGVVKIVVRQ	SRCAP	1301	Q6ZRS2
AVVQSGDTAVMVTAV	PNPT1	71	Q8TCS8
VNVGAQLTTETEVHM	RIOX1	536	Q9H6W3
VNGTVMTTREDKVVI	SPAG17	1426	Q6Q759
IVIQKSMDQFSTAVV	ABCB9	216	Q9NP78
VKPDTQAVEMKVQVT	CCDC15	356	Q0P6D6
VQVVGTSSEVVAMTL	CHRD	441	Q9H2X0
MVVAQVTRESVQQAI	GTF2H4	341	Q92759
QLETINVTMAGKEVF	RECQL	96	P46063
TVEMVIKVFVATSSG	SH3BGR	61	P55822
MVVGSTINDVLAVNT	UBFD1	151	O14562
MKEVLSTGQGNTEVI	ZNF578	71	Q96N58
VQGAIMVSSVVEVVI	SLC23A1	156	Q9UHI7
EVMVNVLGTEKSQIA	RYR3	2071	Q15413
GTESTVITGVDIVMN	TPT1	61	P13693
EKTLQQMEEVVGSVQ	TTC5	51	Q8N0Z6
QMEEVVGSVQGKAQV	TTC5	56	Q8N0Z6
VVSSMAQKVTQAQTE	TRAV19	16	A0A0A6YYK7
MTESQGTVTFKDVAI	ZNF569	1	Q5MCW4
MKEVLSTGQGNTEVI	ZNF611	71	Q8N823
VLAQVTGKSVTVIME	TRRAP	1266	Q9Y4A5
AMVGVAVTVEVTVVN	TGM6	616	O95932
ISGITQTMVEAVAEV	ZNF638	1251	Q14966
TAAMQQGAVTLETTV	ZNF76	551	P36508
LAKSSIVEDGVMVQI	ZFYVE9	1216	O95405
KGAAVEVNLNTMTSV	UGT2A2	416	P0DTE5
IESVIMQISATLVKG	UBE2Q1	366	Q7Z7E8
MVIVSASGAIETVTE	TTC33	231	Q6PID6
ITMVINVSVEVVNTL	DUSP18	46	Q8NEJ0