Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Numb_domain	NUMBL NUMB	2.67e-05	2	97	2	IPR010449
Domain	Numb/numb-like	NUMBL NUMB	2.67e-05	2	97	2	IPR016698
Domain	NumbF	NUMBL NUMB	2.67e-05	2	97	2	PF06311
Domain	PHR	BTBD1 BTBD2	2.64e-04	5	97	2	PF08005
Domain	PHR	BTBD1 BTBD2	2.64e-04	5	97	2	IPR012983
Domain	WHIM1	RSF1 BAZ1A	2.64e-04	5	97	2	PF15612
Domain	WHIM1_dom	RSF1 BAZ1A	2.64e-04	5	97	2	IPR028942
Domain	DDT	RSF1 BAZ1A	3.95e-04	6	97	2	PS50827
Domain	Glyco_transf_10	FUT5 FUT6	7.32e-04	8	97	2	PF00852
Domain	Glyco_tran_10_N	FUT5 FUT6	7.32e-04	8	97	2	PF17039
Domain	Glyco_trans_10	FUT5 FUT6	7.32e-04	8	97	2	IPR001503
Domain	Glyco_tran_10_N	FUT5 FUT6	7.32e-04	8	97	2	IPR031481
Pubmed	Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling.	NUMBL NUMB	8.02e-06	2	99	2	21893032
Pubmed	EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation.	NUMBL NUMB	8.02e-06	2	99	2	31433979
Pubmed	α6 Integrin (α6high)/Transferrin Receptor (CD71)low Keratinocyte Stem Cells Are More Potent for Generating Reconstructed Skin Epidermis Than Rapid Adherent Cells.	ITGA6 TFRC	8.02e-06	2	99	2	28134816
Pubmed	Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis.	NUMB PLK1	8.02e-06	2	99	2	22593191
Pubmed	Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway.	NUMBL NUMB	8.02e-06	2	99	2	34124033
Pubmed	Enrichment of corneal epithelial stem/progenitor cells using cell surface markers, integrin alpha6 and CD71.	ITGA6 TFRC	8.02e-06	2	99	2	18155160
Pubmed	The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia.	KIF16B TFRC	8.02e-06	2	99	2	23749212
Pubmed	Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.	NUMBL NUMB	8.02e-06	2	99	2	27383182
Pubmed	Numb and Numblike regulate sarcomere assembly and maintenance.	NUMBL NUMB	8.02e-06	2	99	2	35104799
Pubmed	Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24.	BTBD1 BTBD2	8.02e-06	2	99	2	11179693
Pubmed	Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike.	NUMBL NUMB	8.02e-06	2	99	2	17513721
Pubmed	Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain.	FUT5 FUT6	8.02e-06	2	99	2	17604274
Pubmed	Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.	NUMBL NUMB	8.02e-06	2	99	2	26069237
Pubmed	Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.	FUT5 FUT6	8.02e-06	2	99	2	1339443
Pubmed	The leukotriene B4 receptor BLT2 protects barrier function via actin polymerization with phosphorylation of myosin phosphatase target subunit 1 in human keratinocytes.	PPP1R12A LTB4R2	8.02e-06	2	99	2	26896822
Pubmed	Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors.	NUMBL NUMB	8.02e-06	2	99	2	31129078
Pubmed	Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.	FUT5 FUT6	2.40e-05	3	99	2	7650030
Pubmed	Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.	FUT5 FUT6	2.40e-05	3	99	2	30808544
Pubmed	Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.	NUMBL NUMB	2.40e-05	3	99	2	10551880
Pubmed	Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21.	FUT5 FUT6	2.40e-05	3	99	2	7782074
Pubmed	Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.	NUMBL NUMB	2.40e-05	3	99	2	25319694
Pubmed	Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.	DOK6 DOK5	2.40e-05	3	99	2	15286081
Pubmed	Chk2-dependent phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) regulates centrosome maturation.	PPP1R12A PLK1	2.40e-05	3	99	2	31416392
Pubmed	Purification and characterization of a human factor that assembles and remodels chromatin.	RSF1 BAZ1A	2.40e-05	3	99	2	10747848
Pubmed	The Notch regulator Numb links the Notch and TCR signaling pathways.	NUMBL NUMB	2.40e-05	3	99	2	15634911
Pubmed	Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis.	NUMBL NUMB	2.40e-05	3	99	2	21571219
Pubmed	Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms.	RSF1 PLK1	2.40e-05	3	99	2	34635673
Pubmed	The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.	RSF1 PLK1	2.40e-05	3	99	2	26259146
Pubmed	Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1.	CNTNAP1 DCC	2.40e-05	3	99	2	18945908
Pubmed	Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I.	BTBD1 BTBD2	2.40e-05	3	99	2	11818025
Pubmed	Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection.	BTBD1 BTBD2	2.40e-05	3	99	2	21092135
Pubmed	The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.	NUMBL NUMB	2.40e-05	3	99	2	24336247
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	GABRG2 SLC3A1 KCNJ6	4.34e-05	24	99	3	22534482
Pubmed	Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.	PPP1R12A PLK1	4.79e-05	4	99	2	29154753
Pubmed	Numb-deficient satellite cells have regeneration and proliferation defects.	NUMBL NUMB	4.79e-05	4	99	2	24170859
Pubmed	miR-125a-3p/FUT5-FUT6 axis mediates colorectal cancer cell proliferation, migration, invasion and pathological angiogenesis via PI3K-Akt pathway.	FUT5 FUT6	4.79e-05	4	99	2	28771224
Pubmed	Numb is required to prevent p53-dependent senescence following skeletal muscle injury.	NUMBL NUMB	4.79e-05	4	99	2	26503169
Pubmed	GABAA receptor subunit mRNA expression in the weaver cerebellum: modulation by cell-cell interactions.	GABRG2 KCNJ6	4.79e-05	4	99	2	8665663
Pubmed	Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.	FUT5 FUT6	4.79e-05	4	99	2	19349624
Pubmed	Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.	NUMBL NUMB	4.79e-05	4	99	2	8755477
Pubmed	Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.	NUMBL NUMB	4.79e-05	4	99	2	17174898
Pubmed	Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.	NUMBL NUMB	4.79e-05	4	99	2	9169836
Pubmed	The Lnx family proteins function as molecular scaffolds for Numb family proteins.	NUMBL NUMB	4.79e-05	4	99	2	11922143
Pubmed	Beclin 1 regulates recycling endosome and is required for skin development in mice.	ITGA6 ATG14 TFRC	6.23e-05	27	99	3	30701202
Pubmed	Galanin receptor 3 - A new pharmacological target in retina degeneration.	ABCA4 GALR3	7.98e-05	5	99	2	36693600
Pubmed	Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.	PPP1R12A PLK1	7.98e-05	5	99	2	18477460
Pubmed	The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.	NUMBL NUMB	7.98e-05	5	99	2	12011466
Pubmed	Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.	FUT5 FUT6	7.98e-05	5	99	2	29593094
Pubmed	BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.	BTBD1 BTBD2	7.98e-05	5	99	2	12878161
Pubmed	Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models.	NUMBL NUMB	1.19e-04	6	99	2	36260685
Pubmed	SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling.	NUMBL NUMB	1.19e-04	6	99	2	37843276
Pubmed	A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.	NUMBL NUMB	1.19e-04	6	99	2	7568168
Pubmed	β1-integrin is a cell-autonomous factor mediating the Numb pathway for cardiac progenitor maintenance.	NUMBL NUMB	1.19e-04	6	99	2	29653101
Pubmed	Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance.	NUMBL NUMB	1.19e-04	6	99	2	31054872
Pubmed	Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.	NUMBL NUMB	1.19e-04	6	99	2	12410312
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	DOK6 DOK5 NUMBL NUMB	1.31e-04	90	99	4	16273093
Pubmed	The enigma of the numb-Notch relationship during mammalian embryogenesis.	NUMBL NUMB	1.67e-04	7	99	2	16508312
Pubmed	NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.	NUMBL NUMB	1.67e-04	7	99	2	28974699
Pubmed	Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.	NUMBL NUMB	1.67e-04	7	99	2	25535389
Pubmed	Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors.	NUMBL NUMB	1.67e-04	7	99	2	24843018
Pubmed	Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.	NUMBL NUMB	1.67e-04	7	99	2	15598981
Pubmed	A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.	DCLRE1B TFRC	1.67e-04	7	99	2	18202258
Pubmed	Capturing novel mouse genes encoding chromosomal and other nuclear proteins.	PPP1R12A BAZ1A	1.67e-04	7	99	2	9701556
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DENND4A PMPCB DIABLO IARS1 RBM26 GEMIN5 DARS2 TFRC BAZ1A NUP133 RBM15B CSTF1 TAF5L	2.03e-04	1425	99	13	30948266
Pubmed	Exosomal MicroRNA Transport from Salivary Mesenchyme Regulates Epithelial Progenitor Expansion during Organogenesis.	NUMBL NUMB	2.22e-04	8	99	2	28041903
Pubmed	Numb regulates somatic cell lineage commitment during early gonadogenesis in mice.	NUMBL NUMB	2.22e-04	8	99	2	28360133
Pubmed	Search for cellular partners of human papillomavirus type 16 E2 protein.	BTBD1 BTBD2	2.85e-04	9	99	2	18305892
Pubmed	Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.	NUMBL NUMB	2.85e-04	9	99	2	9303539
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	IARS1 PPP1R12A RSF1 RHOT2 BAZ1A NAPRT ARMC5 NUMB CERCAM PLK1	3.11e-04	925	99	10	28986522
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PPP1R12A RSF1 CUL9 EMILIN3 RHOT2 RMDN3 HRES1 ZFHX3 TAF5L IQCM ARHGAP33	3.39e-04	1116	99	11	31753913
Pubmed	Tetraspanin CD151 promotes cell migration by regulating integrin trafficking.	ITGA6 TFRC	3.56e-04	10	99	2	17716972
Pubmed	A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.	BTBD1 BTBD2	3.56e-04	10	99	2	17543862
Pubmed	The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis.	NUMBL NUMB	3.56e-04	10	99	2	34571841
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	IARS1 CNTNAP1 GEMIN5 RHOT2 TFRC NUP133 CERCAM PLK1	3.73e-04	613	99	8	22268729
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	RBM26 IPP BTBD1 BTBD2	3.94e-04	120	99	4	27565346
Pubmed	LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.	PPP1R12A PLK1	4.34e-04	11	99	2	22641346
Pubmed	De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.	RSF1 BAZ1A	4.34e-04	11	99	2	31045206
Pubmed	Analysis of Netrin 1 receptors during inner ear development.	ITGA6 DCC	4.34e-04	11	99	2	17616930
Pubmed	The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.	RSF1 BAZ1A	4.34e-04	11	99	2	24800743
Pubmed	Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.	DOK5 CSTF1	4.34e-04	11	99	2	12881723
Pubmed	RBM24 is a major regulator of muscle-specific alternative splicing.	NUMBL NUMB	5.20e-04	12	99	2	25313962
Pubmed	Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath.	CNTNAP1 ITGA6	5.20e-04	12	99	2	18579745
Pubmed	The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.	BTBD1 BTBD2	5.20e-04	12	99	2	19995937
Pubmed	Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.	PPP1R12A PLK1	5.20e-04	12	99	2	24785407
Pubmed	Molecular physiology of renal organic anion transporters.	SLC22A25 SLC22A12	6.13e-04	13	99	2	16403838
Pubmed	Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.	FAM83E FUT6	6.13e-04	13	99	2	24941225
Pubmed	Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.	IARS1 DARS2	6.13e-04	13	99	2	9878398
Pubmed	Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.	SLC22A25 SLC22A12	6.13e-04	13	99	2	15369770
Pubmed	Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.	CUL9 PLK1	7.14e-04	14	99	2	22653443
Pubmed	Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.	GABRG2 GEMIN5	7.14e-04	14	99	2	26449520
Pubmed	Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.	NUMBL NUMB	7.14e-04	14	99	2	14687546
Pubmed	Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis.	NUMBL NUMB	7.14e-04	14	99	2	31300538
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	NUMBL NUMB	7.14e-04	14	99	2	15273690
Pubmed	Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.	NUMBL NUMB	7.14e-04	14	99	2	22865640
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	IARS1 PPP1R12A RBM26 CUL9 DARS2 RMDN3 BAZ1A NUP133 TAF5L	7.70e-04	857	99	9	25609649
Pubmed	Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.	FUT5 FUT6	8.22e-04	15	99	2	11698403
Pubmed	Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.	MAST1 ARHGAP33	9.38e-04	16	99	2	11441184
Pubmed	Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.	SLC22A25 SLC22A12	9.38e-04	16	99	2	19679677
Pubmed	Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.	ITLN1 RBM26	9.38e-04	16	99	2	20014019
Pubmed	Sorting out the cellular functions of sorting nexins.	KIF16B ARHGAP33	1.06e-03	17	99	2	12461558
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GABRG2 DPPA3 BAZ1A NUP133 LY75 PLK1	2.41e-06	174	98	6	65147b0f8c2ccadd5685430d31081520c157536a
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	DOK6 SLC22A12 SLC3A1 MIA2 SLC5A8 FUT6	3.32e-06	184	98	6	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTNAP1 EMILIN3 PTCHD1 FAT2 MAST1 ST8SIA5	3.65e-06	187	98	6	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	mild_COVID-19-RBC\|World / disease group, cell group and cell class (v2)	SLC6A16 SLC25A37 FAM177B FUT5 PLK1	6.11e-06	117	98	5	85210be67ddc31903764b7fa6d7029d9656753d3
ToppCell	mild_COVID-19-RBC\|mild_COVID-19 / disease group, cell group and cell class (v2)	SLC6A16 SLC25A37 FAM177B FUT5 PLK1	6.91e-06	120	98	5	cccea760901558ec18d5cbb71c7971c5a51da571
ToppCell	droplet-Lung-21m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZMYND15 MAMDC4 DPPA3 PTCHD1 ZFHX3	3.51e-05	168	98	5	aaafa7243c44e6852d92e3445335fc4a1018f416
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	GABRG2 DOK6 EMILIN3 CHST1 ADARB2	3.93e-05	172	98	5	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAM83E SYNE4 DISP2 ST8SIA5 CNGA4	4.50e-05	177	98	5	43dce527392f3b8364bb6a55268ce9d6518d3a29
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FA2H HIBADH SLC3A1 ST8SIA5 SLC5A8	4.62e-05	178	98	5	dfed0fbf7a73b8a9e00178ec58dc4592b271c344
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A25 ABCA4 KIF16B DCC IRAG2	4.62e-05	178	98	5	f7f88879a05b2b5fa92cf5317b76f7a3064d1358
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FA2H HIBADH SLC3A1 ST8SIA5 SLC5A8	4.75e-05	179	98	5	d0fa700648db8ce76a8aa689879a25048299fa40
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FA2H HIBADH SLC3A1 ST8SIA5 SLC5A8	4.75e-05	179	98	5	2e49b215b71438400aebb483f2c2c08d5e956961
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A25 ABCA4 KIF16B DCC IRAG2	4.87e-05	180	98	5	2ae39e26a8e7d5d4d3e1e71609a8ec36fd9855aa
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A25 ABCA4 KIF16B DCC IRAG2	5.00e-05	181	98	5	6e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DCC SLC22A12 SLC3A1 SLC5A8 FUT6	5.00e-05	181	98	5	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DCC SLC22A12 SLC3A1 SLC5A8 FUT6	5.00e-05	181	98	5	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A25 ABCA4 KIF16B DCC IRAG2	5.27e-05	183	98	5	b5d041d0a3506c33de72bf14fa0443f4410fddf1
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ATG4A DENND4A ATG14 SLC25A37 TFRC	5.55e-05	185	98	5	e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FA2H ITGA6 ARL4D FAT2 PLK1	6.45e-05	191	98	5	0f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCell	15-Trachea-Epithelial-Neuroendocrine\|Trachea / Age, Tissue, Lineage and Cell class	CRYBB1 MIA2 KCNJ6 DISP2 ST8SIA5	6.45e-05	191	98	5	76311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ATG4A DENND4A ATG14 SLC25A37 TFRC	6.78e-05	193	98	5	305e15ee467826ee08b2617c69f250ad39c11b19
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GABRG2 KCNJ6 MAST1 DISP2 ST8SIA5	6.78e-05	193	98	5	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-erythrocytic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ATG4A DENND4A ATG14 SLC25A37 TFRC	6.78e-05	193	98	5	dd376664906caccc9c2065f8e7a364509e18a5cc
ToppCell	tumor_Lung-B_lymphocytes-GC_B_cells_in_the_DZ\|B_lymphocytes / Location, Cell class and cell subclass	PHF19 RCCD1 TCL1A IRAG2 PLK1	7.12e-05	195	98	5	339e81a3a5b1f71c0d15ef1ef0f6999378704923
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-41\|World / Primary Cells by Cluster	GABRG2 DOK6 DCC KCNJ6 DISP2	7.29e-05	196	98	5	dee0984cd63a1a2fdebb4421af48ab566a5b684e
ToppCell	Neuronal-Excitatory-eC(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC22A25 ABCA4 KIF16B DCC IRAG2	8.02e-05	200	98	5	8c803a0ce25e140b46036f6aabefc5502601f408
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC22A25 ABCA4 KIF16B DCC IRAG2	8.02e-05	200	98	5	82caaee79e697ed4ddea7dd49e99b7abe849604f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAM83E ADARB2 ACOT11 FAM177B FUT6	8.02e-05	200	98	5	ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC22A25 ABCA4 KIF16B DCC IRAG2	8.02e-05	200	98	5	0d559f7d8bfd24bcdc770fe2f3baebfddda9b640
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC22A25 ABCA4 KIF16B DCC IRAG2	8.02e-05	200	98	5	32231471987dd5647c9f7c430ff62dc366b5aea8
ToppCell	Neuronal-Excitatory-eC(RORB)-ESR1---L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC22A25 ABCA4 KIF16B DCC IRAG2	8.02e-05	200	98	5	622ca21b7949ec3d40e17ea08ce4212bbfb963db
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FA2H ITGA6 ADARB2 ACOT11 FUT6	8.02e-05	200	98	5	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	RCCD1 LTB4R2 CERCAM ZFHX3	8.55e-05	105	98	4	8f31edf4183587f5b53941475453c5aa49f10bbd
Disease	serum carcinoembryonic antigen measurement	FAM83E FUT5 FUT6	3.43e-05	20	94	3	EFO_0005760
Disease	alpha-(1;3)-fucosyltransferase 5 measurement	FUT5 FUT6	6.00e-05	4	94	2	EFO_0021979
Disease	mucocutaneous lymph node syndrome	RHBDD1 BTBD1 MICB ZFHX3	1.04e-04	76	94	4	EFO_0004246
Disease	galactoside 3(4)-L-fucosyltransferase measurement	FUT5 FUT6	2.09e-04	7	94	2	EFO_0021853
Disease	alpha-(1,3)-fucosyltransferase 5 measurement	FUT5 FUT6	2.09e-04	7	94	2	EFO_0020136
Disease	immature reticulocyte measurement	DENND4A SLC25A37 TFRC	2.84e-04	40	94	3	EFO_0803545
Disease	breast cancer	ADARB2 KCNJ6	3.56e-04	9	94	2	MONDO_0007254
Disease	underweight body mass index status	DCC ST8SIA5	3.56e-04	9	94	2	EFO_0005936
Disease	metabolite measurement	FAM47A RPH3AL FA2H DCC SLC22A12 NAPRT FBXO39 FUT6	4.27e-04	560	94	8	EFO_0004725
Disease	ovarian carcinoma	FAM47A ABCA4 RCCD1 ADARB2 PTCHD1 ZFHX3	5.77e-04	321	94	6	EFO_0001075
Disease	galectin-3 measurement	ATG14 FUT6	1.17e-03	16	94	2	EFO_0008137
Disease	sweet liking measurement	KIF16B DCC	1.49e-03	18	94	2	EFO_0010156
Disease	phosphatidylethanolamine measurement	GABRG2 PNLIPRP1 DIABLO BAZ1A	2.31e-03	173	94	4	EFO_0010228
Disease	Ovarian Serous Adenocarcinoma	SNRK MAST1	2.43e-03	23	94	2	C1335177
Disease	gestational diabetes	NUMBL PPP1R12A	2.43e-03	23	94	2	EFO_0004593
Disease	brain cancer (implicated_via_orthology)	NUMBL NUMB	3.10e-03	26	94	2	DOID:1319 (implicated_via_orthology)
Disease	myeloperoxidase measurement	NUP133 TAF5L	3.10e-03	26	94	2	EFO_0005243

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSRGYLVRSQWSRIS	NT5C1B	111	Q96P26
RDISTSGYSWLRDRA	MAMDC4	76	Q6UXC1
LSDISARLWFTYRRK	ATG4A	46	Q8WYN0
GRLAVSFRFRTWDLT	CNTNAP1	381	P78357
LWRSYTRRTDGLVFV	ARL4D	86	P49703
SRRSIWDLLLKYRSG	ABCA4	1096	P78363
KLAEARRTTYLSGRW	ATG14	236	Q6ZNE5
TWSSSYRSDRLMSFR	CRYBB1	126	P53674
YSWGLESRSKGRRSD	ACOT11	561	Q8WXI4
GSFRSLRSWLISEGY	ARMC5	451	Q96C12
SWLSRSVTSFFRYRQ	DIABLO	6	Q9NR28
VRTYWLLGERGSSTR	NPR1	1046	P16066
WSLRRAGTARLFFLS	DCLRE1B	16	Q9H816
GLRRGWFTSRLELYS	DISP2	941	A7MBM2
GRSYKTVLDRWRESL	BAZ1A	1106	Q9NRL2
LDETWTVFRRYSRFR	KIF16B	1211	Q96L93
AFSYICRDGTTRRWI	NUMBL	156	Q9Y6R0
LESTWPSRSRSGYFL	DENND4A	856	Q7Z401
PSRSRSGYFLWTKVR	DENND4A	861	Q7Z401
ASWSYTAFVTRGGRL	RCCD1	46	A6NED2
YSRSVRSRSGERWGA	RBM15B	566	Q8NDT2
SRSYSRSRSRSWSKE	RBM26	176	Q5T8P6
LSARWARLYGRLSTR	ADARB2	671	Q9NS39
AFYDWRGFVLTRSFR	IQCM	191	A0A1B0GVH7
YTRLQGGRWSDSRAL	IPP	296	Q9Y573
FRAQRSARGSTFSLW	ARHGEF19	341	Q8IW93
SSAARRRLWGFSESL	PMPCB	11	O75439
SVLWDRERSSFYSLT	NUP133	276	Q8WUM0
SEVRLYTVRWRTSFS	DCC	876	P43146
WRNSSLLRYRTDTGF	ITLN1	161	Q8WWA0
ARSSYITSEILWGYR	KCNJ6	321	P48051
YLRFWAGRIASTSFS	FAM177B	66	A6PVY3
KRIYTFRVRASDWGS	FAT2	526	Q9NYQ8
SNFARWRYGVSITLS	PNLIPRP1	351	P54315
WRYRTITFSGRPSRV	FBXO39	56	Q8N4B4
SLRKYFWTGLRDVDS	LY75	551	O60449
LSALRRYGRDTTWFT	DOK5	181	Q9P104
RYGRDTTWFTFEAGR	DOK5	186	Q9P104
ARASYRRFRTWPSAT	HRES1	71	P13985
RASSFYPRNITLTWR	MICB	226	Q29980
LRSRLWNSTFLEEYS	ITGA6	991	P23229
FSFASSRRADGRRWS	MAST1	76	Q9Y2H9
TWSETGDRYLLKLFR	PAN3	801	Q58A45
WVRRGARLYDLSSFV	FA2H	26	Q7L5A8
GRSWPVLRSYDDFRS	ARHGAP33	91	O14559
SLAYGRTLRFLWAAV	GALR3	201	O60755
LSSLRRYGRDSTWFT	DOK6	181	Q6PKX4
RYGRDSTWFTFESGR	DOK6	186	Q6PKX4
RWGYSGTSDRIRFTV	BTBD1	341	Q9H0C5
RRLGVLATAWLTFYD	HACD1	66	B0YJ81
DTRSWRLYQFSFVGL	GABRG2	231	P18507
LSYFRWRETLRPRSF	FUT6	316	P51993
STRWYRAPEVLLRSS	MAK	161	P20794
DRFSRRSSSWRILGS	IRAG2	396	Q12912
RLFARRGWTYDSVKT	FAM47A	756	Q5JRC9
WVFRQRSEFSSRSGY	CUL9	361	Q8IWT3
SSSSYSGESLRELRW	CCDC177	251	Q9NQR7
ASRYSLYTTGWRPRL	EMILIN3	36	Q9NT22
SDDFRARFWYRRSTT	CSTF1	416	Q05048
SYWTLAYALRLAGAR	CERCAM	471	Q5T4B2
ESRWGYSGTSDRIRF	BTBD2	381	Q9BX70
TGSRTRGRWKYSSND	RSF1	846	Q96T23
ASDRFGRRLVLTWSY	SLC22A12	166	Q96S37
LSDRFGRKFVLRWSY	SLC22A25	166	Q6T423
DEWLYSRRGVRTLLS	DPPA3	76	Q6W0C5
FLWRSFRSVRSRLYV	MIA2	666	Q96PC5
AFSYICRDGTTRRWI	NUMB	126	P49757
SSETSRIYTWARGRV	RPH3AL	191	Q9UNE2
SYFRWRETLRPRSFS	FUT5	331	Q11128
RYDLRRPSFTRTWSG	RPUSD2	16	Q8IZ73
RTARLWSFDRTYPLR	TAF5L	406	O75529
GSRQDFLWRLARAYS	RMDN3	271	Q96TC7
WGSLYRSLLQSSQRR	DARS2	26	Q6PI48
SWAYGARRFLADLTI	SLC6A16	586	Q9GZN6
ERRLGSRWFAYVITA	RHBDD1	96	Q8TEB9
RGDWLLSFVYRTSSV	TMCO4	461	Q5TGY1
RALGAYRDSIFRRLW	SYNE4	181	Q8N205
LWSLTSETTLRRLRY	TMEM191B	316	P0C7N4
RVISGSYSFTWSDAR	FAM83E	246	Q2M2I3
SYSFTWSDARLHRGL	FAM83E	251	Q2M2I3
YSVTLARLRGARWGS	LTB4R2	201	Q9NPC1
TTWTILRRFGYSDAL	RHOT2	266	Q8IXI1
WYRFLLTARFSEDTA	PTCHD1	456	Q96NR3
RTVWRTEGLGAFYRS	SLC25A37	186	Q9NYZ2
SRYWLSLGVRAKRIS	ST8SIA5	286	O15466
IWFQLSRTRTGKYTD	SLC3A1	221	Q07837
PYFRSLSERSLSWIS	SLC5A8	371	Q8N695
RYSAEWKSTVSRLGR	IARS1	126	P41252
WLYSARGDFFRATSR	TFRC	641	P02786
RRRLDKDSGFTYSWH	SNRK	551	Q9NRH2
DGRYRSSDSSFWRLV	TCL1A	81	P56279
YWSRRLRPAAGSFAA	HIBADH	16	P31937
ASRSETFRDTYRLWR	CHST1	241	O43916
DKGRISSRYVRTWSF	CNGA4	101	Q8IV77
SSRYVRTWSFFLDLA	CNGA4	106	Q8IV77
SWRRKYTLFSASSEG	GEMIN5	316	Q8TEQ6
SLSYDSRWTVGSRKR	PHF19	461	Q5T6S3
RAFQGLLDTYSVWRS	NAPRT	281	Q6XQN6
AFRFTWRLARGVIST	TMEM81	116	Q6P7N7
RTDFKASTGWLFRFR	TIGD7	116	Q6NT04
EAFLASRGLTRGYWT	ZMYND15	391	Q9H091
QEYWGSKRSSRTRFT	ZFHX3	2236	Q15911
WSRVGGQRFYSRVLS	UNQ9165/PRO28630	86	Q6UXU0
ARLPYLRTWFRTRSA	PLK1	506	P53350
SLRTSSSYTRRKWED	PPP1R12A	521	O14974