Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF529 ZNF492 ZNF540 KMT2D ZNF699 SALL1 SCRT1 ZBTB22	7.99e-05	1412	22	8	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZBTB22	1.01e-04	1459	22	8	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZBTB22	2.66e-04	1244	22	7	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZBTB22	3.04e-04	1271	22	7	GO:0000987
HumanPheno	Choanal atresia or stenosis	BRCA1 ZNF335 KMT2D SALL1 MSL3	2.65e-06	134	10	5	HP:0000416
HumanPheno	Abnormal choanae morphology	BRCA1 ZNF335 KMT2D SALL1 MSL3	2.65e-06	134	10	5	HP:0000415
HumanPheno	Echogenic fetal bowel	KMT2D ZNF699	3.46e-05	5	10	2	HP:0010943
HumanPheno	Bilateral renal hypoplasia	KMT2D ZNF699	5.18e-05	6	10	2	HP:0012584
HumanPheno	Choanal atresia	BRCA1 ZNF335 KMT2D SALL1	6.08e-05	123	10	4	HP:0000453
Domain	-	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	3.42e-08	679	22	9	3.30.160.60
Domain	zf-C2H2	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	4.08e-08	693	22	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	4.13e-08	694	22	9	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	1.06e-07	775	22	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	1.09e-07	777	22	9	PS00028
Domain	Znf_C2H2-like	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	1.34e-07	796	22	9	IPR015880
Domain	Znf_C2H2	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	1.47e-07	805	22	9	IPR007087
Domain	ZnF_C2H2	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	1.52e-07	808	22	9	SM00355
Domain	zf-C2H2_6	ZNF492 ZNF540 ZNF699 SCRT1 ZNF234	2.71e-05	314	22	5	PF13912
Domain	KRAB	ZNF529 ZNF492 ZNF540 ZNF699 ZNF234	5.07e-05	358	22	5	PS50805
Domain	KRAB	ZNF529 ZNF492 ZNF540 ZNF699 ZNF234	5.07e-05	358	22	5	PF01352
Domain	KRAB	ZNF529 ZNF492 ZNF540 ZNF699 ZNF234	5.85e-05	369	22	5	SM00349
Domain	KRAB	ZNF529 ZNF492 ZNF540 ZNF699 ZNF234	5.92e-05	370	22	5	IPR001909
Pubmed	BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site.	BRCA1 IGF1	3.82e-07	2	22	2	22739988
Pubmed	Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women.	BRCA1 IGF1	3.82e-07	2	22	2	12389335
Pubmed	Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families.	BRCA1 IGF1	3.82e-07	2	22	2	17484040
Pubmed	Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families.	BRCA1 IGF1	1.15e-06	3	22	2	17010055
Pubmed	Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.	BRCA1 IGF1	1.15e-06	3	22	2	18045956
Pubmed	Glucose Concentration in Cell Culture Medium Influences the BRCA1-Mediated Regulation of the Lipogenic Action of IGF-I in Breast Cancer Cells.	BRCA1 IGF1	1.15e-06	3	22	2	33212987
Pubmed	Prospective multicenter cohort study of estrogen and insulin-like growth factor system in BRCA mutation carriers.	BRCA1 IGF1	1.15e-06	3	22	2	26006218
Pubmed	DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.	BRCA1 KMT2D	2.29e-06	4	22	2	25079327
Pubmed	Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.	BRCA1 IGF1	1.07e-05	8	22	2	19843326
Pubmed	Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women.	BRCA1 IGF1	3.46e-05	14	22	2	19672706
Pubmed	The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.	BRCA1 IGF1	1.53e-04	29	22	2	19094228
Pubmed	Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.	IGF1 SALL1	2.38e-04	36	22	2	29891551
Pubmed	Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.	BRCA1 IGF1	3.40e-04	43	22	2	30733279
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	BRCA1 MCM9 SALL1	3.61e-04	222	22	3	37071664
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF529 ZNF492 ZNF540 ZNF335 ZNF699 SALL1 SCRT1 ZNF234 ZBTB22	8.24e-09	718	18	9	28
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_RAG2_KO_NK_CELL_DN	ZNF529 SALL1 MS4A2 CEMIP	1.92e-05	194	22	4	M8864
Coexpression	GSE27786_NEUTROPHIL_VS_MONO_MAC_DN	BRCA1 MCM9 MS4A2 CEMIP	2.12e-05	199	22	4	M4883
Computational	Neighborhood of RAP1A	BRCA1 ZBTB22 MSL3	4.37e-04	140	12	3	MORF_RAP1A
Computational	Neighborhood of PSMF1	BRCA1 ZBTB22 MSL3	7.31e-04	167	12	3	MORF_PSMF1
Computational	Neighborhood of NF1	BRCA1 ZBTB22 MSL3	7.70e-04	170	12	3	MORF_NF1
Computational	Neighborhood of ESR1	BRCA1 ZBTB22 MSL3	7.96e-04	172	12	3	MORF_ESR1
Computational	Neighborhood of PPP2R5B	BRCA1 ZBTB22 MSL3	8.10e-04	173	12	3	MORF_PPP2R5B
Computational	Neighborhood of BNIP1	BRCA1 ZBTB22 MSL3	1.06e-03	190	12	3	MORF_BNIP1
Computational	Neighborhood of ATRX	BRCA1 ZBTB22 MSL3	1.52e-03	215	12	3	MORF_ATRX
Computational	Neighborhood of REV3L	BRCA1 ZBTB22	1.82e-03	58	12	2	MORF_REV3L
Computational	Neighborhood of TFDP2	BRCA1 ZBTB22 MSL3	1.84e-03	230	12	3	MORF_TFDP2
Computational	Neighborhood of IL13	BRCA1 ZBTB22 MSL3	1.94e-03	234	12	3	MORF_IL13
Computational	Neighborhood of IL16	BRCA1 ZBTB22 MSL3	2.06e-03	239	12	3	MORF_IL16
Computational	Neighborhood of MSH3	BRCA1 ZBTB22 MSL3	2.16e-03	243	12	3	MORF_MSH3
Computational	Neighborhood of BRCA1	BRCA1 ZBTB22 MSL3	2.70e-03	263	12	3	MORF_BRCA1
Computational	Neighborhood of PTEN	ZBTB22 MSL3	3.87e-03	85	12	2	MORF_PTEN
Computational	Genes in the cancer module 486.	ALPK2 KMT2D	5.32e-03	100	12	2	MODULE_486
Disease	HOMA-IR	IGF1 MCM9	2.28e-04	33	20	2	EFO_0004501
Disease	Congenital small ears	KMT2D SALL1	3.52e-04	41	20	2	C0152423
Disease	esophagus squamous cell carcinoma (is_implicated_in)	BRCA1 KMT2D	4.25e-04	45	20	2	DOID:3748 (is_implicated_in)
Disease	breast carcinoma (is_marker_for)	BRCA1 KMT2D	9.12e-04	66	20	2	DOID:3459 (is_marker_for)
Disease	family history of Alzheimer’s disease	ALPK2 MS4A2	1.05e-03	71	20	2	EFO_0009268
Disease	hypothyroidism (biomarker_via_orthology)	IGF1 PLOD3	1.34e-03	80	20	2	DOID:1459 (biomarker_via_orthology)
Disease	pancreatic cancer (is_implicated_in)	BRCA1 IGF1	2.59e-03	112	20	2	DOID:1793 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IHSCQKFFETKCFMA	MS4A2	161	Q01362
LKMDHTAFFKKFLTC	ALPK2	1381	Q86TB3
FAFCSMKGCERIKIK	CEMIP	1151	Q8WUJ3
IKDMCIKCFHFSSVK	CFAP44	666	Q96MT7
MAFCKSFRDKGIFLH	PLOD3	491	O60568
HLGECKSFKEKFMKC	COX19	26	Q49B96
GMKFKFHSGEKVLCF	MSL3	6	Q8N5Y2
STKCDHIFCKFCMLK	BRCA1	36	P38398
LFKCCFCDFLKVKMH	IGF1	11	P05019
FFKHKCRFCAKVFGS	SALL1	446	Q9NSC2
MCNKCKHVFVIKADF	MCM9	146	Q9NXL9
FKHFQCKRCKKSFAL	SCRT1	301	Q9BWW7
YMCKKCDKGFFSRLE	ZNF540	271	Q8NDQ6
RKCTEKFLCFMKGHF	MIS12	61	Q9H081
CKVFRFCKSKCHKNF	RSL24D1	26	Q9UHA3
KCNECGKSFRMKIHY	ZNF234	401	Q14588
FKCKECEKSFCMLSH	ZNF492	141	Q9P255
KCMECGKDFRFHSQL	ZNF529	311	Q6P280
KECGKAFHFLACFKK	ZNF699	226	Q32M78
MCDKCGKSFKKRYTF	ZNF335	591	Q9H4Z2
FLCHCGKAFSHKSMR	ZBTB22	486	O15209
ACAIRAKCMFFKDKT	KMT2D	5116	O14686