Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine kinase activity

CSNK2A1 CSNK2A3 MAP3K19

8.82e-04363113GO:0106310
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CSNK2A1 CSNK2A3 MAP3K19

1.60e-03446113GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

CSNK2A1 CSNK2A3 MAP3K19

3.72e-03600113GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

CSNK2A1 CSNK2A3 MAP3K19

5.94e-03709113GO:0016773
GeneOntologyMolecularFunctionkinase activity

CSNK2A1 CSNK2A3 MAP3K19

7.31e-03764113GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CSNK2A1 CSNK2A3 MAP3K19

1.28e-02938113GO:0016772
GeneOntologyCellularComponentprotein kinase CK2 complex

CSNK2A1 CSNK2A3

1.24e-064102GO:0005956
DomainF-box_dom

FBXW10 FBXW10B

8.55e-0475112IPR001810
DomainSer/Thr_kinase_AS

CSNK2A1 CSNK2A3 MAP3K19

1.02e-03357113IPR008271
DomainS_TKc

CSNK2A1 CSNK2A3 MAP3K19

1.04e-03359113SM00220
DomainPROTEIN_KINASE_ST

CSNK2A1 CSNK2A3 MAP3K19

1.06e-03362113PS00108
DomainG-protein_beta_WD-40_rep

FBXW10 FBXW10B

1.10e-0385112IPR020472
DomainProtein_kinase_ATP_BS

CSNK2A1 CSNK2A3 MAP3K19

1.21e-03379113IPR017441
DomainPkinase

CSNK2A1 CSNK2A3 MAP3K19

1.23e-03381113PF00069
DomainPROTEIN_KINASE_ATP

CSNK2A1 CSNK2A3 MAP3K19

2.10e-03459113PS00107
DomainProt_kinase_dom

CSNK2A1 CSNK2A3 MAP3K19

2.52e-03489113IPR000719
DomainPROTEIN_KINASE_DOM

CSNK2A1 CSNK2A3 MAP3K19

2.58e-03493113PS50011
DomainKinase-like_dom

CSNK2A1 CSNK2A3 MAP3K19

3.37e-03542113IPR011009
DomainWD40_repeat_CS

FBXW10 FBXW10B

4.00e-03164112IPR019775
DomainWD40

FBXW10 FBXW10B

9.70e-03259112PF00400
DomainWD40

FBXW10 FBXW10B

1.04e-02268112SM00320
DomainWD40_repeat

FBXW10 FBXW10B

1.07e-02272112IPR001680
DomainWD_REPEATS_1

FBXW10 FBXW10B

1.11e-02278112PS00678
DomainWD_REPEATS_2

FBXW10 FBXW10B

1.12e-02279112PS50082
DomainWD_REPEATS_REGION

FBXW10 FBXW10B

1.12e-02279112PS50294
DomainWD40_repeat_dom

FBXW10 FBXW10B

1.26e-02297112IPR017986
Domain-

FBXW10 FBXW10B

1.57e-023331122.130.10.10
DomainWD40/YVTN_repeat-like_dom

FBXW10 FBXW10B

1.59e-02335112IPR015943
PathwayKEGG_MEDICUS_VARIANT_OLIGOMERIC_CONFORMATION_PRPC_TO_ANTEROGRADE_AXONAL_TRANSPORT

CSNK2A1 CSNK2A3

2.82e-051392M47763
PathwayWP_ALZHEIMERS_DISEASE

CSNK2A1 IRS2 CSNK2A3

4.85e-0426193M42565
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

FBXW10 CDC23 FBXW10B

7.22e-0429993MM15711
PathwayWP_ALZHEIMERS_DISEASE_AND_MIRNA_EFFECTS

CSNK2A1 IRS2 CSNK2A3

9.28e-0432693M39379
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

FBXW10 CDC23 FBXW10B

1.08e-0334393MM15712
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

CSNK2A1 CSNK2A3

1.38e-038992M39563
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

CSNK2A1 CSNK2A3

1.67e-039892M39731
PathwayREACTOME_PROTEIN_FOLDING

CSNK2A1 FBXW10

1.67e-039892M776
PathwayWP_WNT_SIGNALING_WP428

CSNK2A1 CSNK2A3

2.21e-0311392M39669
PathwayWP_MEASLES_VIRUS_INFECTION

CSNK2A1 CSNK2A3

3.18e-0313692M42547
PathwayWP_BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING

CSNK2A1 IRS2

3.56e-0314492M39691
PathwayWP_BREAST_CANCER_PATHWAY

CSNK2A1 CSNK2A3

4.06e-0315492M39739
PathwayREACTOME_METABOLISM_OF_LIPIDS

CSNK2A1 ARSB SRD5A3

5.83e-0362093MM15193
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

FBXW10 ARSB FBXW10B SRD5A3

7.88e-03138994MM15307
PathwayREACTOME_NEDDYLATION

FBXW10 FBXW10B

8.55e-0322692MM15543
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

FBXW10 CDC23 FBXW10B

8.81e-0371993MM14540
PathwayREACTOME_METABOLISM_OF_LIPIDS

CSNK2A1 ARSB SRD5A3

1.02e-0275793M27451
PathwayREACTOME_DISEASES_OF_METABOLISM

ARSB SRD5A3

1.04e-0225092M27554
PathwayREACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS

CSNK2A1 IRS2

1.05e-0225292MM15585
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

CSNK2A1 IRS2

1.13e-0226192MM15676
Pubmed

Assignment of casein kinase 2 alpha sequences to two different human chromosomes.

CSNK2A1 CSNK2A3

9.09e-0821121577469
Pubmed

Molecular cloning of the human casein kinase II alpha subunit.

CSNK2A1 CSNK2A3

9.09e-0821122752008
Pubmed

Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.

FBXW10 FBXW10B

9.09e-08211237450367
Pubmed

FBXW10 promotes hepatocarcinogenesis in male patients and mice.

FBXW10 FBXW10B

9.09e-08211231400758
Pubmed

Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.

CSNK2A1 CSNK2A3

9.09e-0821128420794
Pubmed

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.

CSNK2A1 CSNK2A3

9.09e-08211212860116
Pubmed

Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.

CSNK2A1 CSNK2A3

9.09e-08211214646071
Pubmed

Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.

CSNK2A1 CSNK2A3

2.73e-07311212102635
Pubmed

Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.

CSNK2A1 CSNK2A3

2.73e-07311215684395
Pubmed

Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.

CSNK2A1 CSNK2A3

2.73e-0731121766873
Pubmed

Crystallization and preliminary characterization of crystals of human protein kinase CK2.

CSNK2A1 CSNK2A3

2.73e-07311211092945
Pubmed

Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

CSNK2A1 CSNK2A3

2.73e-0731122174700
Pubmed

Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.

CSNK2A1 CSNK2A3

2.73e-07311220625391
Pubmed

FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males.

FBXW10 FBXW10B

9.09e-07511237277019
Pubmed

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

CSNK2A1 CSNK2A3

1.91e-06711211239457
Pubmed

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

CSNK2A1 CSNK2A3

2.54e-06811212393879
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

CSNK2A1 IRS2 CSNK2A3 CDC23

1.26e-0549711436774506
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

CSNK2A1 MRPL39 CSNK2A3

4.59e-0523111336597993
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CSNK2A1 IRS2 FBXW10 FBXW10B

5.65e-0573011434857952
Pubmed

The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.

FBXW10 FBXW10B

1.10e-045011226275350
Pubmed

Systematic analysis and nomenclature of mammalian F-box proteins.

FBXW10 FBXW10B

1.65e-046111215520277
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

CSNK2A1 IRS2 FBXW10 CDC23

2.20e-04103811426673895
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CSNK2A1 IRS2 CDC23 ARSB

2.90e-04111611431753913
InteractionFBXW10B interactions

FBXW10 FBXW10B

6.65e-073102int:FBXW10B
InteractionCFAP97 interactions

CSNK2A1 CSNK2A3 CDC23

2.54e-0657103int:CFAP97
InteractionCT45A3 interactions

CSNK2A1 CSNK2A3

7.96e-069102int:CT45A3
InteractionF2RL3 interactions

CSNK2A1 CSNK2A3

7.96e-069102int:F2RL3
InteractionEFCAB14 interactions

CSNK2A1 CSNK2A3

9.95e-0610102int:EFCAB14
InteractionANKRD36C interactions

CSNK2A1 CSNK2A3

1.46e-0512102int:ANKRD36C
InteractionIPMK interactions

CSNK2A1 CSNK2A3

1.72e-0513102int:IPMK
InteractionHAGHL interactions

CSNK2A1 CSNK2A3

1.72e-0513102int:HAGHL
InteractionFBXW10 interactions

FBXW10 FBXW10B

1.72e-0513102int:FBXW10
InteractionPCDH18 interactions

CSNK2A1 CSNK2A3

2.65e-0516102int:PCDH18
InteractionKLHL6 interactions

CSNK2A1 CSNK2A3

6.08e-0524102int:KLHL6
InteractionCT45A1 interactions

CSNK2A1 CSNK2A3

7.16e-0526102int:CT45A1
InteractionFBXO22 interactions

CSNK2A1 IRS2 CSNK2A3 CDC23

9.41e-05540104int:FBXO22
InteractionANKRD36 interactions

CSNK2A1 CSNK2A3

1.09e-0432102int:ANKRD36
InteractionNAP1L4 interactions

CSNK2A1 MRPL39 CDC23

1.20e-04206103int:NAP1L4
InteractionGPATCH2 interactions

CSNK2A1 CSNK2A3

1.38e-0436102int:GPATCH2
InteractionMMP1 interactions

CSNK2A1 CSNK2A3

1.46e-0437102int:MMP1
InteractionAUTS2 interactions

CSNK2A1 CSNK2A3

1.71e-0440102int:AUTS2
InteractionABR interactions

CSNK2A1 CSNK2A3

1.80e-0441102int:ABR
InteractionLEO1 interactions

CSNK2A1 MRPL39 CDC23

2.90e-04278103int:LEO1
InteractionLYST interactions

CSNK2A1 CSNK2A3

3.01e-0453102int:LYST
InteractionANKRD36B interactions

CSNK2A1 CSNK2A3

3.86e-0460102int:ANKRD36B
InteractionPRKCI interactions

CSNK2A1 MRPL39 CSNK2A3

4.11e-04313103int:PRKCI
InteractionSH3KBP1 interactions

CSNK2A1 CSNK2A3 CDC23

4.18e-04315103int:SH3KBP1
InteractionGPATCH2L interactions

CSNK2A1 CSNK2A3

5.56e-0472102int:GPATCH2L
InteractionGRAMD1B interactions

CSNK2A1 CSNK2A3

6.03e-0475102int:GRAMD1B
InteractionSNAPC4 interactions

CSNK2A1 CDC23

6.19e-0476102int:SNAPC4
InteractionHIRIP3 interactions

CSNK2A1 CSNK2A3

8.11e-0487102int:HIRIP3
InteractionNKTR interactions

CSNK2A1 CSNK2A3

8.67e-0490102int:NKTR
InteractionPCGF3 interactions

CSNK2A1 CSNK2A3

8.67e-0490102int:PCGF3
InteractionPRKCZ interactions

CSNK2A1 MRPL39 CSNK2A3

9.15e-04412103int:PRKCZ
InteractionOPTN interactions

CSNK2A1 CSNK2A3 CDC23

9.80e-04422103int:OPTN
InteractionPIP4K2B interactions

CSNK2A1 CSNK2A3

9.86e-0496102int:PIP4K2B
InteractionRNF111 interactions

CSNK2A1 CSNK2A3

1.01e-0397102int:RNF111
InteractionEIF3CL interactions

CSNK2A1 CSNK2A3

1.03e-0398102int:EIF3CL
InteractionPCGF5 interactions

CSNK2A1 CSNK2A3

1.09e-03101102int:PCGF5
InteractionFBRS interactions

CSNK2A1 CSNK2A3

1.11e-03102102int:FBRS
InteractionSAP30BP interactions

CSNK2A1 CSNK2A3

1.18e-03105102int:SAP30BP
InteractionZNF687 interactions

CSNK2A1 CSNK2A3

1.41e-03115102int:ZNF687
InteractionARK2N interactions

CSNK2A1 CSNK2A3

1.43e-03116102int:ARK2N
InteractionSKP1 interactions

CSNK2A1 FBXW10 CDC23

1.46e-03484103int:SKP1
InteractionHDAC1 interactions

CSNK2A1 IRS2 CSNK2A3 CDC23

1.46e-031108104int:HDAC1
Cytoband17p12

FBXW10 FBXW10B

6.10e-054911217p12
CytobandEnsembl 112 genes in cytogenetic band chr11p15

CSNK2A3 OLFML1

7.70e-03564112chr11p15
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW10 FBXW10B

7.06e-061172559
GeneFamilyWD repeat domain containing

FBXW10 FBXW10B

4.19e-0326272362
CoexpressionMIKKELSEN_MEF_LCP_WITH_H3K4ME3

FBXW10 OLFML1 FBXW10B

2.49e-05142113MM840
CoexpressionGSE3982_DC_VS_NEUTROPHIL_LPS_STIM_UP

MRPL39 CDC23 SRD5A3

6.80e-05199113M5391
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma-5|TCGA-Breast / Sample_Type by Project: Shred V9

CSNK2A1 CSNK2A3

2.71e-04101112f4db710b2510cdbee26dd5c3b581c85fe6f0be00
ToppCellSevere-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

IRS2 MAP3K19

5.57e-04145112a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCellThalamus-Macroglia-POLYDENDROCYTE|Thalamus / BrainAtlas - Mouse McCarroll V32

CSNK2A1 ARSB

7.37e-041671121e144c03409df94ccd39760842590e8ea7487e29
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IRS2 FBXW10

7.81e-04172112cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

IRS2 FBXW10

7.81e-041721123a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCellSevere-B_naive-8|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

IRS2 MAP3K19

7.99e-04174112f3f8c924420f46321bd47e2b97f18c7241541599
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

IRS2 FBXW10

8.36e-0417811291bf3c7c05d2e67ee590389a1b36c517d0ed7ebf
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

IRS2 FBXW10

8.36e-04178112be4976bbfd9ebbc568155ede99a07670c43aa372
ToppCellEndothelial-B-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

OLFML1 MAP3K19

8.64e-041811124fe0215d08f03d4e24749d70fce01b7aa22906fd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OLFML1 SRD5A3

8.64e-041811126d80795f96aac11fec1c946d1f2d16cfe6e38d9a
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MRPL39 SRD5A3

9.72e-04192112efbd52b3d2b6d3fb9ed6bc3f36aca9f4f1fcbc49
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Myeloid|GW10 / Sample Type, Dataset, Time_group, and Cell type.

FBXW10 MAP3K19

9.92e-041941124f28841c7f37884fc34c6689cd6976c6559d23f1
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Myeloid-Microglia|GW10 / Sample Type, Dataset, Time_group, and Cell type.

FBXW10 MAP3K19

9.92e-04194112459e836bcdb6742333684ac23d960efa5e99702f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBXW10 MAP3K19

9.92e-041941124a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Deuterosomal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FBXW10 FBXW10B

1.02e-03197112861e8df9bd74dc5e17bafdc1fb3fef546753c73a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBXW10 OLFML1

1.04e-03199112c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBXW10 OLFML1

1.04e-03199112dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell(03)_KRT6B+|World / shred by cell type by condition

IRS2 SRD5A3

1.04e-031991129feaf8649b3f68f30b8cb6b045a2caa2dd343c7f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

FBXW10 MAP3K19

1.05e-032001125c638c80661017c85f9390f1b398ac7728c8f001
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell|GW10 / Sample Type, Dataset, Time_group, and Cell type.

FBXW10 MAP3K19

1.05e-03200112604a88633d4162337e394155c7346dbdef8b9f5a
DrugCotinine (-) [486-56-6]; Up 200; 22.6uM; MCF7; HT_HG-U133A

IRS2 ARSB SRD5A3

1.03e-041991131511_UP
Diseasemyocardial infarction (biomarker_via_orthology)

CSNK2A1 CSNK2A3

1.56e-03160112DOID:5844 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GAWTLMGHEYMEMKN

CDC23

366

Q9UJX2
VMAWSMVGKYERCLM

FBXW10

596

Q5XX13
VMAWSMVGKYERCLM

FBXW10B

596

O95170
KMMDTHGSWMKDAVY

OLFML1

156

Q6UWY5
GMMMFIWSSAHQYKC

SRD5A3

206

Q9H8P0
GYMRMWCGSKLSMEH

IRS2

741

Q9Y4H2
YSLDMWRLGCMLASM

CSNK2A3

211

Q8NEV1
YSLDMWSLGCMLASM

CSNK2A1

211

P68400
HMVGKWHLGMYRKEC

ARSB

141

P15848
SDMLKSMHGTPYWMA

MAP3K19

1221

Q56UN5
GEVNKAYWRSCAMMM

MRPL39

136

Q9NYK5
KCVKGFMMEMASWDG

C12orf4

496

Q9NQ89