Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCC3 BRIP1 DNAH10 MYO19 KIF1B MCM4 HSP90AA5P MACF1 DHX32 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.25e-0644113114GO:0016887
GeneOntologyMolecularFunctionATP-dependent protein folding chaperone

HSP90AA5P HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

6.16e-06401315GO:0140662
GeneOntologyMolecularFunctionATP-dependent activity

ABCC3 BRIP1 DNAH10 MYO19 KIF1B MCM4 HSP90AA5P MYO5C MACF1 DHX32 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.24e-0561413115GO:0140657
GeneOntologyMolecularFunctionCTP binding

HSP90AA1 HSP90AB1

4.27e-0521312GO:0002135
GeneOntologyMolecularFunctionprotein folding chaperone

HSP90AA5P HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.18e-04731315GO:0044183
GeneOntologyMolecularFunctionsulfonylurea receptor binding

HSP90AA1 HSP90AB1

1.28e-0431312GO:0017098
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCC3 BRIP1 DNAH10 MYO19 KIF1B MCM4 HSP90AA5P RRAGC MACF1 DHX32 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.74e-0477513115GO:0017111
GeneOntologyMolecularFunctionUTP binding

HSP90AA1 HSP90AB1

2.54e-0441312GO:0002134
GeneOntologyMolecularFunctionpyrophosphatase activity

ABCC3 BRIP1 DNAH10 MYO19 KIF1B MCM4 HSP90AA5P RRAGC MACF1 DHX32 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.05e-0483913115GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ABCC3 BRIP1 DNAH10 MYO19 KIF1B MCM4 HSP90AA5P RRAGC MACF1 DHX32 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.10e-0484013115GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ABCC3 BRIP1 DNAH10 MYO19 KIF1B MCM4 HSP90AA5P RRAGC MACF1 DHX32 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.10e-0484013115GO:0016818
GeneOntologyMolecularFunctionpyrimidine ribonucleotide binding

HSP90AA1 HSP90AB1

4.22e-0451312GO:0032557
GeneOntologyMolecularFunctiondATP binding

HSP90AA1 HSP90AB1

4.22e-0451312GO:0032564
GeneOntologyMolecularFunctionadenyl deoxyribonucleotide binding

HSP90AA1 HSP90AB1

6.30e-0461312GO:0032558
GeneOntologyMolecularFunctionactin filament binding

FLNB FLNC MYO19 ITPRID2 NEB MYO5C MACF1

7.58e-042271317GO:0051015
GeneOntologyMolecularFunctioncytoskeletal protein binding

FLNB FLNC AMPD1 MYO19 KIF1B CAPN6 ITPRID2 NEB KRIT1 MYO5C TTLL12 MACF1 USH2A NOS2 HSP90AA1 HSP90AB1 MYBPC3

8.57e-04109913117GO:0008092
GeneOntologyMolecularFunctionpurine deoxyribonucleotide binding

HSP90AA1 HSP90AB1

8.78e-0471312GO:0032554
GeneOntologyMolecularFunctionTPR domain binding

HSP90AA1 HSP90AB1

1.17e-0381312GO:0030911
GeneOntologyMolecularFunctionunfolded protein binding

HSP90AA5P HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.46e-031261315GO:0051082
GeneOntologyMolecularFunctiondeoxyribonucleotide binding

HSP90AA1 HSP90AB1

1.49e-0391312GO:0032552
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

AMPD1 ADAR MTHFD2L

1.68e-03361313GO:0016814
GeneOntologyMolecularFunctionnitric-oxide synthase regulator activity

HSP90AA1 HSP90AB1

1.86e-03101312GO:0030235
GeneOntologyMolecularFunctioncell adhesion molecule binding

FLNB CDH23 THBS1 NRXN3 PTPRB PTPRZ1 MACF1 NOS2 HSPA5 CNTN1 HSP90AB1

1.99e-0359913111GO:0050839
GeneOntologyMolecularFunctiondisordered domain specific binding

HSP90AA1 HSP90AA2P HSP90AB1

2.12e-03391313GO:0097718
GeneOntologyMolecularFunctionlarge ribosomal subunit rRNA binding

RPLP0 RPLP0P6

2.26e-03111312GO:0070180
GeneOntologyMolecularFunctionpyrimidine nucleotide binding

HSP90AA1 HSP90AB1

2.26e-03111312GO:0019103
GeneOntologyMolecularFunctionmyosin binding

AMPD1 MYO19 USH2A MYBPC3

2.38e-03851314GO:0017022
DomainFilamin

FLNB FLNC MYCBP2

4.53e-05111243PF00630
DomainFILAMIN_REPEAT

FLNB FLNC MYCBP2

4.53e-05111243PS50194
DomainFilamin/ABP280_rpt

FLNB FLNC MYCBP2

4.53e-05111243IPR001298
DomainFilamin/ABP280_repeat-like

FLNB FLNC MYCBP2

4.53e-05111243IPR017868
DomainHeat_shock_protein_90_CS

HSP90AA1 HSP90AB1

1.31e-0431242IPR019805
DomainFN3

FLNC EPHA6 PTPRB PTPRZ1 USH2A CNTN1 MYBPC3

2.37e-041851247SM00060
DomainHsp90_fam

HSP90AA1 HSP90AB1

2.60e-0441242IPR001404
DomainHsp90_N

HSP90AA1 HSP90AB1

2.60e-0441242IPR020575
DomainHSP90

HSP90AA1 HSP90AB1

2.60e-0441242PF00183
DomainHSP90

HSP90AA1 HSP90AB1

2.60e-0441242PS00298
DomainPHR

BTBD6 MYCBP2

4.32e-0451242IPR012983
DomainPHR

BTBD6 MYCBP2

4.32e-0451242PF08005
DomainACTININ_2

FLNB FLNC MACF1

4.59e-04231243PS00020
DomainACTININ_1

FLNB FLNC MACF1

4.59e-04231243PS00019
DomainActinin_actin-bd_CS

FLNB FLNC MACF1

4.59e-04231243IPR001589
DomainFN3_dom

FLNC EPHA6 PTPRB PTPRZ1 USH2A CNTN1 MYBPC3

4.95e-042091247IPR003961
DomainIg_E-set

FLNB FLNC MYCBP2 SNRNP200 EBF4

6.48e-041041245IPR014756
Domainfn3

EPHA6 PTPRB PTPRZ1 USH2A CNTN1 MYBPC3

7.46e-041621246PF00041
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

HNRNPDL FLNB FLNC RPLP0 MYCBP2 MATR3 MCM4 ITPRID2 PRPF8 TRRAP ADAR HP1BP3 MYO5C NRP1 SUPT5H CKAP2L MACF1 FLOT1 SNRNP200 HSPA5 HSP90AB1

3.75e-1010241332124711643
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

HNRNPDL BRIP1 RPLP0 PTBP2 RPLP0P6 MATR3 LIN54 MCM4 ICE1 PAF1 PRPF8 ADAR HP1BP3 TASOR2 RBM27 QSER1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

7.05e-109541332036373674
Pubmed

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.

HNRNPDL MYCBP2 MATR3 MCM4 ADAR PER2 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.59e-091751331025756610
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

HNRNPDL FLNC GBF1 GDAP2 MATR3 MCM4 ADAR PER2 PIK3C2A WDR62 USP47

1.70e-092321331125515538
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

FLNB FRMPD4 RPLP0 SPOUT1 RPLP0P6 MATR3 MCM4 ITPRID2 PRPF8 ADAR HSP90AA5P HP1BP3 MYO5C FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.14e-099491331936574265
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

HNRNPDL FLNB FLNC SPOUT1 MYCBP2 MYO19 MATR3 ADNP2 MCM4 PRPF8 TRRAP ADAR NEK9 PIK3C2A WASHC5 MACF1 TANC1 PPIH SNRNP200 HSPA5 HSP90AA1 HSP90AB1

9.77e-0913531332229467282
Pubmed

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

HNRNPDL FLNB FLNC RPLP0 MATR3 MCM4 PRPF8 TTLL12 SUPT5H MACF1 PPIH FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.42e-087071331619738201
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

HNRNPDL FLNB FLNC GBF1 RPLP0 MYCBP2 MATR3 MCM4 PAF1 PRPF8 ADAR NEK9 TTLL12 RBM27 MACF1 PPIH SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.62e-0811491332035446349
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

FLNB FLNC CDH23 PRPF8 TRRAP SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

2.67e-082351331030258100
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

FLNB FLNC PTBP2 MATR3 MCM4 PAF1 PRPF8 ADAR HSP90AA5P KIAA2013 MACF1 FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

2.81e-088471331735235311
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

HNRNPDL FLNB FLNC RPLP0 MATR3 PRPF8 ADAR NEK9 TASOR2 N4BP2 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.91e-085511331434728620
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

FLNB FLNC RPLP0 MYCBP2 MCM4 PRPF8 TRRAP HP1BP3 TASOR2 TTLL12 IARS2 SUPT5H MACF1 SNRNP200 USP47

3.41e-086531331522586326
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

HNRNPDL FLNB MATR3 ITPRID2 PAF1 PRPF8 ADAR RRAGC HP1BP3 PIK3C2A SUPT5H MACF1 PPIH FLOT1 SNRNP200

3.92e-086601331532780723
Pubmed

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

HNRNPDL RPLP0 MATR3 PRPF8 ADAR SNRNP200

4.92e-0852133624591637
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

FLNB LPAR3 TMEM144 EPHA6 SLC16A9 MYCBP2 PTBP2 KIF1B AGPAT3 TRRAP CASC2 NEK9 HP1BP3 TASOR2 NRP1 PTPRB PCNX4 MACF1 TANC1 QSER1 MMP16 NBR1

5.32e-0814891332228611215
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

HNRNPDL FLNC RPLP0 MYCBP2 MATR3 KIF1B MCM4 PRPF8 HP1BP3 IARS2 TANC1 SNRNP200 HSPA5 WDR62 HSP90AA1 HSP90AB1

9.05e-088091331632129710
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

HNRNPDL DCAF15 MATR3 LIN54 PRPF8 SKP2 NEK9 TASOR2 TTLL12 THBS1 PER2 WASHC5 KCTD5 PPIH FLOT1 SNRNP200 WDR62 USP47 HSP90AA1

9.28e-0811551331920360068
Pubmed

A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.

FLNB FLNC GBF1 RPLP0 PAF1 HSPA5 HSP90AA1 HSP90AB1

1.44e-07153133827462432
Pubmed

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.

FLNB MATR3 PRPF8 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.59e-07104133736055981
Pubmed

Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.

HNRNPDL FLNB RPLP0 MCM4 PAF1 PRPF8 HSP90AA5P MACF1 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.66e-075381331328524877
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

FLNC RPLP0 MYCBP2 PTBP2 MATR3 PRPF8 TRRAP ADAR HP1BP3 RBM27 SUPT5H MACF1 PPIH FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.77e-0710821331838697112
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

HNRNPDL RPLP0 RPLP0P6 MATR3 MCM4 PAF1 PRPF8 TRRAP ADAR HSP90AA5P HP1BP3 KCTD5 SUPT5H DHX32 PPIH SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.85e-0713351332029229926
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

HNRNPDL FLNB BRIP1 RPLP0 MATR3 ITPRID2 PRPF8 ADAR HP1BP3 FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.28e-076521331431180492
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

FLNB RPLP0 MATR3 NEB PRPF8 ADAR MACF1 SNRNP200 HSP90AB1

3.20e-07234133936243803
Pubmed

The HSP90 family of genes in the human genome: insights into their divergence and evolution.

HSP90AA5P HSP90AA1 HSP90AA2P HSP90AB1

3.59e-0716133416269234
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

HNRNPDL RPLP0 RPLP0P6 MATR3 MCM4 PAF1 PRPF8 HSP90AA5P HP1BP3 ZNF12 RBM27 MACF1 PPIH SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.47e-0711531331829845934
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

HNRNPDL FLNB FLNC BRIP1 MATR3 MCM4 ITPRID2 HP1BP3 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

4.79e-074941331226831064
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

FLNC MYCBP2 TRRAP NEK9 MACF1 USP47

4.90e-0776133627542412
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

FLNB FLNC AMPD1 MYCBP2 KIF1B NEB PAF1 NEK9 PIK3C2A MACF1 HSP90AA1 HSP90AB1

5.11e-074971331223414517
Pubmed

Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth.

PTPRB PTPRZ1 CNTN1

5.44e-075133312700241
Pubmed

Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.

FLNB FLNC RPLP0 TRRAP KCTD5 HSPA5 HSP90AA1 HSP90AB1

5.88e-07184133823402259
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

RPLP0 MATR3 MCM4 ICE1 PAF1 PRPF8 ADAR NEK9 HP1BP3 IARS2 RBM27 MACF1 SNRNP200 WDR62 HSP90AA1 HSP90AB1

6.16e-079341331633916271
Pubmed

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

HNRNPDL RPLP0 MATR3 PRPF8 TTLL12 SUPT5H SNRNP200 HSPA5 HSP90AA1 HSP90AB1

6.21e-073301331032529326
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

FLNB MCM4 PAF1 PRPF8 TTLL12 SUPT5H SNRNP200 HSPA5 HSP90AA1 HSP90AB1

6.56e-073321331032786267
Pubmed

Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.

HNRNPDL FLNC AMPD1 RPLP0 PTBP2 MATR3 MCM4 PRPF8 ADAR HP1BP3 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

8.06e-077251331427025967
Pubmed

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.

MYCBP2 RPLP0P6 ITPRID2 PRPF8 NEK9 MYO5C FLOT1 SNRNP200 HSPA5

8.76e-07264133932814769
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

FLNB RPLP0 SPOUT1 MATR3 PRPF8 TRRAP ADAR HP1BP3 RBM27 WASHC5 PPIH FLOT1 SNRNP200 WDR62 HSP90AA1

9.40e-078471331535850772
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

FLNB MATR3 PRPF8 HP1BP3 MYO5C FLOT1 SNRNP200 HSP90AA1 HSP90AB1

9.92e-07268133933024031
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RPLP0 MYCBP2 TMEM126B ITPRID2 PAF1 PRPF8 HP1BP3 TTLL12 IARS2 PIK3C2A N4BP2 MACF1 SENP2 CHID1 TANC1 FLOT1 SNRNP200 NBR1 HSPA5 WDR62

1.00e-0614871332033957083
Pubmed

Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy.

HSPA5 HSP90AA1 HSP90AB1

1.08e-066133332206096
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

FLNC GBF1 LIN54 MCM4 PRPF8 SKP2 TRRAP ADAR IARS2 QSER1 SNRNP200 NBR1 USP47 HSP90AA1 HSP90AB1

1.09e-068571331525609649
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

HNRNPDL FLNB GBF1 PTBP2 MCM4 PRPF8 ADAR NEK9 TTLL12 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.13e-066381331333239621
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

HNRNPDL FLNB FLNC AMPD1 GBF1 LIN54 KIF1B PRPF8 ADAR RRAGC HP1BP3 IARS2 PIK3C2A WASHC5 SUPT5H HSPA5 MVK HSP90AA1 HSP90AB1

1.19e-0613671331932687490
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

FLNB GBF1 ICE1 ITPRID2 PRPF8 MYO5C THBS1 SNRNP200

1.19e-06202133833005030
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

BRIP1 RPLP0 MATR3 PAF1 ADAR SUPT5H SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.26e-063571331037059091
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

HNRNPDL FLNB FLNC RPLP0 SPOUT1 MATR3 MCM4 PAF1 PRPF8 ADAR RBM27 SUPT5H SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.30e-069891331636424410
Pubmed

A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.

GBF1 CNTLN HSPA5 HSP90AA1 HSP90AB1

1.40e-0650133523703321
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

HNRNPDL FLNB RPLP0 SPOUT1 MATR3 ITPRID2 PRPF8 ADAR HP1BP3 TASOR2 THBS1 IARS2 RBM27 FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.53e-0612571331836526897
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

HNRNPDL BRIP1 GBF1 RPLP0 MYCBP2 MATR3 KIF1B MCM4 ITPRID2 TRRAP SNRNP200 WDR62 USP47 HSP90AB1

1.73e-067741331415302935
Pubmed

Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.

HSPA5 HSP90AA1 HSP90AB1

1.89e-067133312471035
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

HNRNPDL FLNB BTBD6 SPOUT1 MCM4 ITPRID2 CNTLN PAF1 HP1BP3 SUPT5H PPIH USH2A SNRNP200

1.93e-066701331322990118
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

FLNB MYCBP2 KIF1B ADNP2 PRPF8 MTMR10 KRIT1 TTLL12 THBS1 SUPT5H MACF1 REPS2 FLOT1 SNRNP200 HSPA5 USP47 HSP90AA1 HSP90AB1

2.09e-0612851331835914814
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

FLNB FLNC MATR3 MCM4 PRPF8 IARS2 RBM27 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.42e-064771331131300519
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

HNRNPDL FLNB FLNC RPLP0 PTBP2 MATR3 LIN54 NEB PRPF8 KIAA2013 HP1BP3 TASOR2 ADAMTS12 NRXN3 N4BP2 MACF1 HSPA5 HSP90AA1 HSP90AB1

2.59e-0614421331935575683
Pubmed

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

FLNB PAF1 IARS2 SUPT5H SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.65e-06225133825277244
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

HNRNPDL RPLP0 MATR3 PRPF8 TRRAP PPIH SNRNP200 HSPA5 HSP90AA2P HSP90AB1

2.78e-063901331017643375
Pubmed

Linking nuclear matrix-localized PIAS1 to chromatin SUMOylation via direct binding of histones H3 and H2A.Z.

FLNB FLNC MATR3 ADAR HP1BP3 USH2A HSPA5

2.81e-06159133734537242
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

HNRNPDL FLNB RPLP0 SPOUT1 PTBP2 MATR3 PRPF8 ADAR RBM27 SUPT5H MACF1 SNRNP200 HSP90AA1 HSP90AB1

2.81e-068071331422681889
Pubmed

A human MAP kinase interactome.

FLNC ZBTB8OS ADNP2 ITPRID2 NEB N4BP2 MACF1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.89e-064861331120936779
Pubmed

Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes.

SKP2 HSP90AA1 HSP90AB1

3.02e-068133318818696
Pubmed

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.

HNRNPDL FLNB RPLP0 MATR3 MCM4 PRPF8 HP1BP3 TTLL12 PPIH SNRNP200 HSP90AB1

3.19e-064911331122623428
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

HNRNPDL FLNB GBF1 RPLP0 MATR3 PRPF8 TTLL12 THBS1 MACF1 MTX1 SNRNP200 HSPA5 HSP90AB1

3.69e-067111331333022573
Pubmed

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

PRPF8 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

3.80e-0661133519875381
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

HNRNPDL DCAF15 RPLP0 MATR3 MCM4 PRPF8 ADAR HP1BP3 PPIH SNRNP200 HSPA5 HSP90AA1 HSP90AB1

3.86e-067141331328302793
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

HNRNPDL RPLP0 MATR3 PAF1 PRPF8 ADAR HP1BP3 SUPT5H SNRNP200 HSPA5 HSP90AA1 HSP90AB1

3.91e-066051331228977666
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF355P ZNF716 ZNF43 ZNF679

4.51e-0629133414563677
Pubmed

A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response.

SKP2 HSP90AA1 HSP90AB1

4.52e-069133337250795
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

FLNB FLNC RPLP0 RPLP0P6 MATR3 MCM4 NEB PRPF8 MACF1 DHX32 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

4.69e-068441331425963833
Pubmed

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.

HNRNPDL MATR3 SKP2 ADAR HP1BP3 PYHIN1 HSPA5 HSP90AB1

4.82e-06244133830349055
Pubmed

SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.

MATR3 MCM4 TRRAP HSP90AA1 HSP90AB1

4.82e-0664133526511642
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

KLHL6 FLNB MCM4 PRPF8 ADAR THBS1 MACF1 HSP90AA1 HSP90AB1

5.70e-06332133937433992
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

HNRNPDL FLNB RPLP0 PRPF8 PTPRB KCTD5 SNRNP200 HSPA5 HSP90AA1

5.84e-06333133932665550
Pubmed

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.

HNRNPDL PTBP2 SUPT5H HSPA5 HSP90AA1 HSP90AB1

5.87e-06116133637117180
Pubmed

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.

FLNB FLNC PRPF8

6.43e-0610133336357400
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

HNRNPDL RPLP0 MATR3 PRPF8 ADAR RBM27 WASHC5 SNRNP200 HSPA5

6.90e-06340133924332808
Pubmed

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.

RPLP0 MCM4 PRPF8 ADAR SNRNP200 HSPA5 HSP90AA1 HSP90AB1

7.25e-06258133821081666
Pubmed

Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.

HNRNPDL RPLP0 SPOUT1 LIPH PPIH HSPA5 HSP90AA1 HSP90AB1

7.46e-0625913389811942
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

FLNB FLNC RPLP0 MCM4 PRPF8 TRRAP RRAGC SUPT5H SNRNP200

7.58e-06344133930333137
Pubmed

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.

MTX1 NBR1 HSP90AA1 HSP90AB1

7.67e-0633133429149599
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

HNRNPDL FLNB GBF1 RPLP0 DNAH10 MATR3 MCM4 PRPF8 ADAR NEK9 TTLL12 IARS2 SUPT5H FLOT1 SNRNP200 NBR1 HSPA5 HSP90AB1

8.68e-0614251331830948266
Pubmed

Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.

FLNC TRRAP USH2A

8.82e-0611133324349473
Pubmed

Proteomic and functional evidence for a P2X7 receptor signalling complex.

P2RX7 PTPRZ1 HSP90AA1

8.82e-0611133311707406
Pubmed

BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.

MATR3 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

9.25e-0673133532347575
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

FLNB FLNC MACF1 FLOT1 HSPA5 HSP90AA1 HSP90AB1

9.37e-06191133733762435
Pubmed

Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.

RPLP0 MATR3 MCM4 CCDC7 KCTD5 HSPA5 HSP90AA1 HSP90AB1

9.82e-06269133830442662
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

RPLP0 MATR3 TRRAP ADAR SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.06e-05272133831010829
Pubmed

Defining the membrane proteome of NK cells.

GBF1 RPLP0 MYCBP2 MATR3 AGPAT3 MCM4 PRPF8 ADAR KIAA2013 PIK3C2A CHID1 FLOT1 NBR1 HSPA5 HSP90AA1 HSP90AB1

1.06e-0511681331619946888
Pubmed

In vitro nuclear interactome of the HIV-1 Tat protein.

MATR3 PAF1 PRPF8 TRRAP ADAR HP1BP3 SNRNP200

1.07e-05195133719454010
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

FLNB MATR3 ITPRID2 ADAR RBM27 HSPA5 HSP90AA1 HSP90AB1

1.12e-05274133834244482
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

FLNB FLNC GBF1 RPLP0 KIF1B MCM4 PAF1 NEK9 TTLL12 WASHC5 SUPT5H MACF1 SNRNP200 HSPA5 MVK USP47 HSP90AA1 HSP90AB1

1.15e-0514551331822863883
Pubmed

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.

KIF1B HSPA5 HSP90AA1

1.17e-0512133323569248
Pubmed

Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.

RPLP0 MCM4 HSPA5 HSP90AB1

1.22e-053713349798653
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

KLHL6 HNRNPDL RPLP0 MATR3 PRPF8 RBM27 KCTD5 QSER1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.23e-056781331230209976
Pubmed

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.

RPLP0 PTBP2 MATR3 PAF1 PRPF8 TTLL12 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.25e-054631331034901782
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

HNRNPDL FLNB RPLP0 EPHA6 MATR3 MCM4 PRPF8 HP1BP3 IARS2 FLOT1 HSPA5 HSP90AA1 HSP90AB1

1.35e-058031331336517590
Pubmed

A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.

RPLP0 MATR3 HSPA5 HSP90AA1

1.36e-0538133418247557
Pubmed

CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.

FLNB FLNC RPLP0 ITPRID2 KCTD5 MTX1 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.37e-054681331036042349
Pubmed

Profiling of Parkin-binding partners using tandem affinity purification.

HNRNPDL RPLP0 MATR3 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.39e-05203133724244333
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

FLNB FLNC RPLP0 MYCBP2 MATR3 PRPF8 HP1BP3 IARS2 MACF1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.42e-058071331330575818
Pubmed

Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process.

NOS2 HSP90AB1

1.45e-052133221357526
InteractionCRY2 interactions

KLHL6 HNRNPDL DCAF15 MYCBP2 MATR3 MCM4 ADAR PER2 SNRNP200 HSP90AA1 HSP90AB1

5.31e-0819413011int:CRY2
InteractionAR interactions

MYCBP2 RPLP0P6 MATR3 LIN54 GRB7 ITPRID2 PRPF8 SKP2 TRRAP ADAR NEK9 MYO5C TTLL12 RBM27 SENP2 QSER1 REPS2 FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

3.65e-0799213022int:AR
InteractionEED interactions

HNRNPDL FLNB RPLP0 SPOUT1 MYCBP2 MYO19 MATR3 CAPN6 MCM4 PRPF8 TRRAP ADAR NEK9 HP1BP3 TASOR2 TTLL12 PIK3C2A WASHC5 SUPT5H MACF1 TANC1 FLOT1 SNRNP200 NBR1 HSPA5 HSP90AA1 HSP90AB1

4.38e-07144513027int:EED
InteractionCALD1 interactions

FLNB FLNC GBF1 RPLP0 MYO19 ITPRID2 MYO5C IARS2 FLOT1 HSPA5 HSP90AA1

1.21e-0626513011int:CALD1
InteractionITGB3 interactions

FLNB FLNC MCM4 PRPF8 TRRAP THBS1 PTPRZ1 SUPT5H SNRNP200

1.61e-061701309int:ITGB3
InteractionACTN4 interactions

GBF1 RPLP0 MYO19 KIF1B NEB PRPF8 MYO5C NRP1 PER2 PIK3C2A NOS2 HSPA5 HSP90AB1

1.96e-0640013013int:ACTN4
InteractionKCTD9 interactions

FLNB MATR3 PRPF8 TASOR2 NRP1 KCTD5 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.04e-0622513010int:KCTD9
InteractionFBXW11 interactions

HNRNPDL FLNC GBF1 GDAP2 MATR3 MCM4 ADAR PYHIN1 PER2 PIK3C2A TANC1 WDR62 USP47 HSP90AA1

2.32e-0647313014int:FBXW11
InteractionSVIL interactions

MYCBP2 MYO19 MTMR10 MYO5C PTPRB P2RX7 FLOT1 HSPA5 HSP90AA1 HSP90AB1

2.79e-0623313010int:SVIL
InteractionSMC5 interactions

HNRNPDL BRIP1 RPLP0 PTBP2 RPLP0P6 MATR3 LIN54 MCM4 ICE1 PAF1 PRPF8 ADAR HP1BP3 TASOR2 RBM27 QSER1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

6.32e-06100013020int:SMC5
InteractionSPDL1 interactions

FLNB FLNC CDH23 PRPF8 TRRAP NEK9 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

6.37e-0631513011int:SPDL1
InteractionMYH9 interactions

DCAF15 FLNB GBF1 MYO19 ITPRID2 TRRAP MYO5C THBS1 IARS2 PIK3C2A MACF1 FLOT1 HSPA5 USP47 HSP90AA1 HSP90AB1 MYBPC3

7.21e-0675413017int:MYH9
InteractionCHMP4C interactions

HNRNPDL FLNB FLNC RPLP0 RPLP0P6 MATR3 PRPF8 ADAR HSP90AA5P IARS2 MACF1 SNRNP200 USP47 HSP90AA1 HSP90AA2P HSP90AB1

9.17e-0668713016int:CHMP4C
InteractionSFN interactions

GBF1 MYCBP2 GRK4 MATR3 KIF1B GRB7 ITPRID2 NEB PRPF8 RRAGC PIK3C2A MACF1 TANC1 HSPA5 WDR62 USP47

1.00e-0569213016int:SFN
InteractionATOH1 interactions

FLNC MYCBP2 TRRAP NEK9 MACF1 USP47

1.30e-05801306int:ATOH1
InteractionKIF20A interactions

HNRNPDL FLNB FLNC RPLP0 PTBP2 GDAP2 MATR3 MCM4 ITPRID2 PRPF8 TRRAP ADAR HSP90AA5P PIK3C2A MACF1 FLOT1 CCDC171 SNRNP200 HSP90AA2P HSP90AB1

1.33e-05105213020int:KIF20A
InteractionCIT interactions

HNRNPDL FLNB FLNC RPLP0 SPOUT1 RPLP0P6 MATR3 MCM4 PAF1 PRPF8 TRRAP ADAR HP1BP3 PYHIN1 RBM27 SUPT5H MACF1 PPIH FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.68e-05145013024int:CIT
InteractionDBN1 interactions

DCAF15 FLNB RPLP0 MYCBP2 MYO19 ITPRID2 MYO5C PIK3C2A SUPT5H FLOT1 HSPA5 HSP90AB1

1.68e-0541713012int:DBN1
InteractionFLNA interactions

DCAF15 FLNB FLNC MYO19 CAPN6 ITPRID2 PRPF8 MYO5C PER2 PIK3C2A FLOT1 NBR1 HSPA5 HSP90AA1 HSP90AB1

1.91e-0564813015int:FLNA
InteractionOBSL1 interactions

HNRNPDL FLNB FLNC RPLP0 MATR3 PRPF8 TRRAP ADAR HP1BP3 TASOR2 ZNF12 P2RX7 SUPT5H MACF1 FLOT1 SNRNP200 HSPA5 HSP90AB1

1.99e-0590213018int:OBSL1
InteractionDCTN2 interactions

FLNB GBF1 DNAH10 MYO19 MATR3 KIF1B MCM4 MYO5C IARS2 N4BP2 HSP90AB1

2.00e-0535613011int:DCTN2
InteractionCCDC8 interactions

FLNB RPLP0 MYCBP2 MATR3 MCM4 ITPRID2 PRPF8 MYO5C NRP1 CKAP2L MACF1 FLOT1 SNRNP200 HSPA5 HSP90AB1

2.21e-0565613015int:CCDC8
InteractionFUS interactions

HNRNPDL MYCBP2 PTBP2 MATR3 PAF1 PRPF8 ADAR HP1BP3 GIMAP8 SUPT5H PPIH SNRNP200 NBR1 HSPA5 HSP90AA1 HSP90AB1

3.01e-0575713016int:FUS
InteractionTNIP1 interactions

FLNB FRMPD4 RPLP0 SPOUT1 RPLP0P6 MATR3 MCM4 ITPRID2 PRPF8 ADAR HSP90AA5P HP1BP3 MYO5C NRP1 FLOT1 SNRNP200 NBR1 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

3.34e-05121713021int:TNIP1
InteractionNUPR1 interactions

HNRNPDL FLNB MATR3 ITPRID2 PAF1 PRPF8 ADAR RRAGC HP1BP3 PIK3C2A SUPT5H MACF1 PPIH FLOT1 SNRNP200

3.51e-0568313015int:NUPR1
InteractionENO1 interactions

ZNF355P FLNC GBF1 KIF1B NEB PAF1 PRPF8 PER2 SUPT5H SENP2 QSER1 NOS2 MVK HSP90AA1 HSP90AB1

4.72e-0570113015int:ENO1
InteractionLRRC31 interactions

FLNB GBF1 ICE1 ITPRID2 PRPF8 MYO5C THBS1 SNRNP200

5.62e-052051308int:LRRC31
InteractionFGD5 interactions

FLNB FLNC TRRAP MACF1 FLOT1 HSPA5 HSP90AA1 HSP90AB1

6.02e-052071308int:FGD5
InteractionCDKL4 interactions

HSP90AA5P HSP90AA1 HSP90AB1

7.15e-05131303int:CDKL4
InteractionA1BG interactions

GRB7 MTX1 WDR62 HSP90AA1

7.41e-05351304int:A1BG
InteractionSTIP1 interactions

HNRNPDL FLNB GBF1 PTBP2 GRK4 MCM4 NEB PRPF8 ADAR HSP90AA5P NEK9 TTLL12 NOS2 SNRNP200 NBR1 HSPA5 HSP90AA1 HSP90AB1

8.21e-05100613018int:STIP1
InteractionDOCK5 interactions

BRIP1 MYCBP2 TRRAP IARS2 HSP90AA1 HSP90AB1

8.35e-051111306int:DOCK5
InteractionYWHAB interactions

GBF1 MYCBP2 MATR3 KIF1B ITPRID2 CNTLN NEB SKP2 TRRAP PIK3C2A MACF1 TANC1 SNRNP200 HSPA5 WDR62 USP47 HSP90AA1 HSP90AB1

9.07e-05101413018int:YWHAB
InteractionSIRT7 interactions

FLNB FLNC RPLP0 MYCBP2 MCM4 PRPF8 TRRAP HP1BP3 TASOR2 TTLL12 IARS2 SUPT5H MACF1 SNRNP200 USP47

9.21e-0574413015int:SIRT7
InteractionFOXM1 interactions

DCAF15 LIN54 PRPF8 TRRAP SNRNP200 HSP90AA1

9.22e-051131306int:FOXM1
InteractionAVIL interactions

BRIP1 MYO5C WDR62 USP47

9.26e-05371304int:AVIL
InteractionPRMT1 interactions

HNRNPDL FLNB FLNC GBF1 RPLP0 MATR3 MCM4 PRPF8 ADAR NEK9 TASOR2 SUPT5H N4BP2 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.00e-0492913017int:PRMT1
InteractionTULP2 interactions

BRIP1 KIF1B PAF1 MYO5C

1.14e-04391304int:TULP2
InteractionFN1 interactions

HNRNPDL FLNB FLNC RPLP0 MATR3 PRPF8 TTLL12 THBS1 SUPT5H MACF1 PPIH FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.15e-0484813016int:FN1
InteractionCUL2 interactions

HNRNPDL FLNB FLNC RPLP0 EPHA6 MATR3 SKP2 KCTD5 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.18e-0459113013int:CUL2
InteractionBGLT3 interactions

MATR3 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

1.24e-04751305int:BGLT3
InteractionPGK1 interactions

MYO5C CCDC7 PYHIN1 PER2 PIK3C2A SUPT5H MACF1 TANC1 HSP90AA1 HSP90AB1

1.36e-0436713010int:PGK1
InteractionSSRP1 interactions

HNRNPDL MATR3 MCM4 PAF1 PRPF8 TRRAP ADAR NEK9 NRP1 PYHIN1 SUPT5H PPIH SNRNP200 HSPA5

1.39e-0468513014int:SSRP1
InteractionCDK9 interactions

FLNB RPLP0 MATR3 PAF1 SKP2 TRRAP ADAR HSP90AA5P HP1BP3 RBM27 SUPT5H HSPA5 HSP90AA1 HSP90AB1

1.39e-0468513014int:CDK9
InteractionYWHAG interactions

GBF1 MYCBP2 MATR3 KIF1B ITPRID2 CNTLN TRRAP PYHIN1 TTLL12 IARS2 PIK3C2A N4BP2 MACF1 TANC1 NOS2 SNRNP200 NBR1 WDR62 HSP90AA1 HSP90AB1

1.45e-04124813020int:YWHAG
InteractionSENP3 interactions

RPLP0 MYCBP2 MATR3 MCM4 PAF1 TRRAP PYHIN1 HSP90AA1 HSP90AB1

1.49e-043011309int:SENP3
InteractionPLS3 interactions

DCAF15 FLNB FLNC GBF1 PRPF8 PYHIN1 NBR1 HSPA5

1.54e-042371308int:PLS3
InteractionDUSP16 interactions

ITPRID2 PRPF8 TASOR2 PIK3C2A N4BP2 SNRNP200 NBR1 WDR62

1.54e-042371308int:DUSP16
InteractionFASN interactions

HNRNPDL DCAF15 FLNB FLNC GBF1 MATR3 LYSMD4 PRPF8 TRRAP PER2 KCTD5 CKAP2L MTX1 NOS2 NBR1 HSPA5 HSP90AA1 HSP90AB1

1.62e-04106213018int:FASN
InteractionSCG2 interactions

SKP2 HSP90AA1 HSP90AB1

1.67e-04171303int:SCG2
InteractionPRC1 interactions

HNRNPDL FLNB FLNC GBF1 RPLP0 RPLP0P6 MATR3 GRB7 MCM4 PRPF8 TRRAP ADAR HP1BP3 FLOT1 SNRNP200 HSP90AA2P HSP90AB1

1.75e-0497313017int:PRC1
InteractionRUVBL2 interactions

MATR3 PRPF8 TRRAP ADAR RRAGC HP1BP3 SENP2 NOS2 SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.78e-0461613013int:RUVBL2
InteractionNPAS1 interactions

MYO19 ADAR THBS1 WASHC5 N4BP2 DHX32 QSER1 HSP90AB1

1.93e-042451308int:NPAS1
InteractionNPHP1 interactions

FLNB FLNC TTLL12 HSPA5 HSP90AA1 HSP90AB1

1.99e-041301306int:NPHP1
InteractionSTK36 interactions

FRMPD4 TRRAP HSP90AA5P HSP90AA1

2.01e-04451304int:STK36
InteractionDNAJA2 interactions

PRPF8 TRRAP NEK9 IARS2 PIK3C2A N4BP2 FLOT1 NOS2 HSPA5 WDR62 HSP90AA1 HSP90AB1

2.05e-0454213012int:DNAJA2
InteractionSIRT6 interactions

FLNB RPLP0 MYCBP2 MATR3 MCM4 PRPF8 SKP2 TRRAP ADAR TASOR2 RBM27 SUPT5H SNRNP200

2.14e-0462813013int:SIRT6
InteractionMECP2 interactions

FLNC RPLP0 SPOUT1 MYCBP2 PTBP2 MATR3 PRPF8 TRRAP ADAR HP1BP3 PYHIN1 RBM27 SUPT5H MACF1 PPIH FLOT1 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.18e-04128713020int:MECP2
InteractionSRPK2 interactions

GBF1 RPLP0 MYCBP2 PTBP2 MATR3 MCM4 PRPF8 ADAR HP1BP3 PYHIN1 RBM27 MACF1 SNRNP200 HSP90AA2P

2.22e-0471713014int:SRPK2
InteractionITGA4 interactions

HNRNPDL FLNB RPLP0 MATR3 MCM4 PRPF8 HP1BP3 TTLL12 ST8SIA4 PPIH SNRNP200 HSP90AB1

2.24e-0454713012int:ITGA4
InteractionCCT8 interactions

DCAF15 ZNF705A FLNB FLNC GBF1 PRPF8 ZNF705G PER2 MACF1 SENP2 NOS2 HSPA5

2.35e-0455013012int:CCT8
InteractionTNNI3K interactions

HSP90AA1 HSP90AB1 MYBPC3

2.36e-04191303int:TNNI3K
InteractionYAP1 interactions

FLNB GBF1 RPLP0 RPLP0P6 MATR3 PAF1 PRPF8 SKP2 TRRAP ADAR NEK9 THBS1 FLOT1 SNRNP200 HSPA5 USP47 HSP90AA1 HSP90AB1

2.36e-04109513018int:YAP1
InteractionTSSK6 interactions

SPOUT1 HSP90AA5P HSP90AA1 HSP90AB1

2.38e-04471304int:TSSK6
InteractionGLDC interactions

FLNB MATR3 CAPN6 ITPRID2 ADAR RBM27 HSPA5 HSP90AA1 HSP90AB1

2.41e-043211309int:GLDC
InteractionPPP1R12A interactions

HNRNPDL DCAF15 MYCBP2 MYO19 MYO5C TTLL12 MACF1 USP47 HSP90AB1

2.46e-043221309int:PPP1R12A
InteractionTTC9C interactions

MYO19 SKP2 ADAR TTLL12 HSP90AA1 HSP90AB1

2.54e-041361306int:TTC9C
InteractionCHMP4B interactions

FLNB FLNC RPLP0 MYCBP2 RPLP0P6 MYO19 MATR3 ITPRID2 PRPF8 ADAR FLOT1 SNRNP200 HSP90AA2P HSP90AB1

2.56e-0472713014int:CHMP4B
InteractionMETTL14 interactions

HNRNPDL FLNC RPLP0 MATR3 MCM4 PRPF8 ADAR USH2A SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.68e-0455813012int:METTL14
InteractionBAP1 interactions

HNRNPDL FLNB FLNC GBF1 RPLP0 MYCBP2 MATR3 MCM4 PAF1 PRPF8 ADAR NEK9 TTLL12 RBM27 MACF1 PPIH SNRNP200 HSPA5 HSP90AA1 HSP90AB1

2.86e-04131413020int:BAP1
InteractionWARS1 interactions

HNRNPDL FLNB FLNC GBF1 TRRAP HSPA5 MVK

2.94e-041971307int:WARS1
InteractionSNRPA interactions

HNRNPDL PTBP2 MATR3 PAF1 PRPF8 TRRAP ADAR IARS2 SUPT5H SNRNP200 NBR1

2.94e-0448213011int:SNRPA
InteractionPDIK1L interactions

HSP90AA5P HSP90AA1 HSP90AB1

3.20e-04211303int:PDIK1L
InteractionUBR4 interactions

FLNB MYCBP2 PRPF8 NRP1 SUPT5H SNRNP200 NBR1 HSP90AA1 HSP90AB1

3.22e-043341309int:UBR4
InteractionPTPRB interactions

HP1BP3 PTPRB P2RX7 CNTN1

3.27e-04511304int:PTPRB
InteractionNELFE interactions

HNRNPDL PTBP2 SUPT5H NBR1 HSPA5 HSP90AA1 HSP90AB1

3.32e-042011307int:NELFE
InteractionKIF23 interactions

HNRNPDL FLNB RPLP0 RPLP0P6 MATR3 GRB7 PRPF8 ADAR HSP90AA5P MYO5C PER2 MACF1 FLOT1 SNRNP200 HSPA5 HSP90AA2P HSP90AB1

3.44e-04103113017int:KIF23
InteractionUNC45B interactions

HSP90AA5P HSP90AA1 HSP90AB1

3.69e-04221303int:UNC45B
InteractionSPTAN1 interactions

MYCBP2 MYO19 TRRAP MYO5C TANC1 FLOT1 MTX1 NBR1 HSPA5 HSP90AA1 HSP90AB1

3.75e-0449613011int:SPTAN1
InteractionSMC1A interactions

HNRNPDL DCAF15 MATR3 MCM4 PRPF8 TRRAP ADAR NEK9 SNRNP200 HSP90AB1

3.86e-0441813010int:SMC1A
InteractionCAP1 interactions

FLNB GBF1 MCM4 NEK9 HSPA5 HSP90AA1 HSP90AB1

3.96e-042071307int:CAP1
InteractionCEBPA interactions

HNRNPDL MYCBP2 MATR3 LIN54 MCM4 PAF1 SKP2 TRRAP ADAR HP1BP3 CCDC7 TTLL12 RBM27 MACF1 QSER1 PPIH SNRNP200 HSPA5 MVK

3.98e-04124513019int:CEBPA
InteractionMCM5 interactions

FLNB FLNC MATR3 MCM4 PRPF8 NEK9 SNRNP200 WDR62 HSP90AA1 HSP90AB1

4.01e-0442013010int:MCM5
InteractionGBP2 interactions

TRRAP HSP90AA5P HSP90AA1 HSP90AB1

4.07e-04541304int:GBP2
InteractionSPTBN1 interactions

MYCBP2 MYO19 KIF1B TRRAP ADAR MYO5C FLOT1 MTX1 HSPA5 HSP90AA1

4.08e-0442113010int:SPTBN1
InteractionDHX15 interactions

HNRNPDL FLNB MATR3 TMEM126B GRB7 PRPF8 TRRAP ADAR SNRNP200 HSPA5 HSP90AB1

4.15e-0450213011int:DHX15
InteractionNUDCD2 interactions

HNRNPDL FLNB RPLP0 PRPF8 PTPRB KCTD5 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

4.32e-0442413010int:NUDCD2
InteractionMEPCE interactions

HNRNPDL RPLP0 RPLP0P6 MATR3 PRPF8 HSP90AA5P HP1BP3 PYHIN1 MACF1 PPIH SNRNP200 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.33e-0485913015int:MEPCE
InteractionHSP90AA2P interactions

HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.37e-04551304int:HSP90AA2P
InteractionDNAJC7 interactions

PRPF8 TRRAP PYHIN1 IARS2 PIK3C2A NOS2 HSPA5 WDR62 HSP90AA1 HSP90AB1

4.40e-0442513010int:DNAJC7
InteractionCSNK2A1 interactions

KLHL6 HNRNPDL GBF1 RPLP0 ZNF177 KIF1B PAF1 PRPF8 TRRAP HP1BP3 NRP1 SUPT5H MACF1 HSPA5 HSP90AA1 HSP90AB1

4.41e-0495613016int:CSNK2A1
InteractionIQGAP1 interactions

FLNB RPLP0 MYCBP2 MYO19 MATR3 ITPRID2 PRPF8 MYO5C PIK3C2A FLOT1 HSPA5 HSP90AB1

4.49e-0459113012int:IQGAP1
InteractionSUMO2 interactions

FLNB MCM4 PAF1 PRPF8 HP1BP3 TTLL12 SUPT5H SENP2 SNRNP200 HSPA5 HSP90AA1 HSP90AB1

4.49e-0459113012int:SUMO2
InteractionMYEF2 interactions

RPLP0 MYCBP2 MATR3 ADNP2 PYHIN1 FLOT1

4.61e-041521306int:MYEF2
InteractionHSP90AB1 interactions

GBF1 RPLP0 EPHA6 MYCBP2 RPLP0P6 MYO19 NEB PRPF8 HSP90AA5P IARS2 NOS2 NBR1 HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

4.62e-0496013016int:HSP90AB1
InteractionCRYL1 interactions

BRIP1 MYO5C PIK3C2A HSP90AB1

4.68e-04561304int:CRYL1
InteractionLIMA1 interactions

FLNB GBF1 MYCBP2 MYO19 PRPF8 MTMR10 MYO5C PIK3C2A FLOT1 HSPA5

4.73e-0442913010int:LIMA1
InteractionLAMTOR5 interactions

KLHL6 KIF1B RRAGC MTHFD2L HSPA5 USP47

4.77e-041531306int:LAMTOR5
InteractionRFLNB interactions

DCAF15 CAPN6 TRRAP

4.81e-04241303int:RFLNB
InteractionPLEC interactions

GBF1 MYO19 PRPF8 PER2 N4BP2 MACF1 QSER1 FLOT1 NOS2 HSPA5

4.82e-0443013010int:PLEC
GeneFamilyFibronectin type III domain containing

EPHA6 PTPRB PTPRZ1 USH2A CNTN1 MYBPC3

1.01e-04160846555
GeneFamilyHeat shock 90kDa proteins

HSP90AA1 HSP90AB1

2.11e-045842586
CoexpressionGSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_UP

LPAR3 TBC1D30 GRK4 NRP1 CKAP2L PPIH MTX1 USP47

7.47e-061991318M8103
CoexpressionGSE24726_WT_VS_E2_2_KO_PDC_DAY6_POST_DELETION_UP

NIPAL3 MTMR10 RRAGC HP1BP3 NRP1 ZNF12 SENP2 PPIH

7.75e-062001318M8063
CoexpressionLAKE_ADULT_KIDNEY_C24_ENDOTHELIAL_CELLS_AEA_AND_DVR

RPLP0 PTPRB PIK3C2A MACF1 HSPA5 HSP90AA1 HSP90AB1

1.17e-051521317M39243
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|368C / Donor, Lineage, Cell class and subclass (all cells)

LIN54 MCM4 MYO5C CFAP65 LIPH CKAP2L REPS2 WDR62

5.78e-081751338fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|368C / Donor, Lineage, Cell class and subclass (all cells)

LIN54 MCM4 MYO5C CFAP65 LIPH CKAP2L REPS2 WDR62

5.78e-08175133836c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FRMPD4 EPHA6 DNAH10 NEB SCN10A CES4A USH2A

5.86e-071621337bf886e22ff2a20353499004b53f25fb9e6574896
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 MATR3 HP1BP3 PYHIN1 THBS1 MACF1 ST8SIA4

1.38e-0618413371154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

BRIP1 GBF1 MYCBP2 MCM4 MACF1 ST8SIA4 HSPA5

1.48e-0618613378571956890fc9894d766ba294a28e376b4aba428
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 FLNB NRP1 PTPRB GIMAP8 ST8SIA4 REPS2

1.53e-0618713373699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHL6 FLNB NRP1 PTPRB GIMAP8 ST8SIA4 REPS2

1.53e-061871337033ba52c0c2f9978784947098fa697368ae44834
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRMPD4 EPHA6 CCDC7 SCN10A CES4A USH2A

4.95e-06145133696712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CATSPERE NRP1 MACF1 CATSPERB REPS2 CNTN1

8.70e-0616013360293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CATSPERE NRP1 MACF1 CATSPERB REPS2 CNTN1

8.70e-0616013363eaae86fa08f7651021316f8e5811bf48055591e
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MYO5C PER2 LIPH MACF1 CATSPERB TANC1

1.65e-0517913366e965e424eebef50f0202cff75f458be395cfca1
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LPAR3 NRXN3 LIPH SPDYA REPS2 NOS2

1.81e-051821336818b5155ec81f0059048d6070a108116ecd72e3c
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

KLHL6 GBF1 DNAH10 MATR3 GIMAP8 PIK3C2A

1.92e-051841336ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

GBF1 MYCBP2 MCM4 MACF1 ST8SIA4 HSPA5

1.98e-051851336a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

EPHA6 GRB7 MYO5C PTPRZ1 CKAP2L WDR62

2.37e-05191133639220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

GBF1 MYCBP2 MCM4 MACF1 ST8SIA4 HSPA5

2.37e-0519113369454f642c3621370fa23640b631301346b300950
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

EPHA6 GRB7 MYO5C NRXN3 PTPRZ1 CKAP2L

2.44e-05192133625378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

THBS1 PER2 PIK3C2A HSPA5 HSP90AA1 HSP90AB1

2.44e-0519213366bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

THBS1 PER2 PIK3C2A HSPA5 HSP90AA1 HSP90AB1

2.52e-051931336dbf0fe496254320c894568c31e5f9ce63707d1b5
ToppCellcritical-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FLNB SLC16A9 ITPRID2 HP1BP3 PER2 PTPRZ1

2.74e-051961336dbf14f5851c2b779a8b35e820c4584ea9096e49d
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CAPN6 NRP1 MMP16 HSPA5 CNTN1 HSP90AB1

2.82e-05197133605e303fff86db31f7b742324c64980eb2b9cff9a
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPLP0 CAPN6 NRP1 MMP16 HSPA5 CNTN1

2.90e-051981336d9ffc6589ed510ffa60c591f2a0fe123210f1455
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABCC3 FLNB MYCBP2 ITPRID2 HP1BP3 PTPRZ1

2.99e-05199133632bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLNB ITPRID2 NRP1 PTPRB PIK3C2A MACF1

3.07e-052001336dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellVE|World / Condition, Cell_class and T cell subcluster

HNRNPDL MYCBP2 ADAR HP1BP3 MACF1 HSP90AA1

3.07e-0520013368ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellsevere|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HNRNPDL HP1BP3 FLOT1 HSPA5 HSP90AA1 HSP90AB1

3.07e-052001336accc618d6b960bff30cb531c1226295bfc8650f6
ToppCellsevere-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HNRNPDL HP1BP3 PYHIN1 HSPA5 HSP90AA1 HSP90AB1

3.07e-0520013366aa77955017d073a96324e4db6b9950a2ec46cf8
ToppCellCOVID-19|World / Disease, condition lineage and cell class

MYCBP2 ADAR MACF1 HSPA5 HSP90AA1 HSP90AB1

3.07e-0520013367dec470c379cd89f05a0f37c8628b21f136e52f0
DrugAC1L9PMA

NOS2 HSP90AA1 HSP90AA2P HSP90AB1

1.24e-06151284CID000451405
Drugchaetochromin

NOS2 HSP90AA1 HSP90AA2P

1.72e-0651283CID000053277
DrugCalpain inhibitor I

ABCC3 CAPN6 SKP2 SENP2 NOS2 HSPA5 MVK HSP90AA1 HSP90AA2P HSP90AB1

4.27e-0628012810CID000004332
Drugdimethyl pimelimidate

MYO5C HSP90AA1 HSP90AA2P HSP90AB1

4.31e-06201284CID000065403
Drugdienochlor

HSPA5 HSP90AA1 HSP90AA2P

5.98e-0671283CID000016686
DrugNSC330499

HSP90AA1 HSP90AA2P HSP90AB1

5.98e-0671283CID000433447
Drugtamoxifen aziridine

KRIT1 HSP90AA1 HSP90AA2P HSP90AB1

6.45e-06221284CID003033894
Drugphenyldichloroarsine

HSP90AA1 HSP90AA2P HSP90AB1

9.52e-0681283CID000012762
Drug5,8-quinolinedione

HSP90AA1 HSP90AA2P HSP90AB1

1.42e-0591283CID000388306
DrugAdenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; PC3; HT_HG-U133A

GRK4 GRB7 NIPAL3 SKP2 THBS1 NRXN3 SCN10A WDR62

1.55e-0519612886760_DN
DrugIndoprofen [31842-01-0]; Up 200; 14.2uM; PC3; HT_HG-U133A

ABCC3 NEB SKP2 CCDC7 KCNV1 THBS1 MMP16 CNTN1

1.61e-0519712884249_UP
DrugFlunixin meglumine [42461-84-7]; Up 200; 8.2uM; PC3; HT_HG-U133A

ABCC3 DCAF15 AMPD1 GRK4 GRB7 THBS1 SCN10A MMP16

1.67e-0519812884273_UP
DrugPropranolol hydrochloride [318-98-9]; Down 200; 13.6uM; PC3; HT_HG-U133A

BRIP1 TBC1D30 GRB7 NIPAL3 SKP2 NEK9 QSER1 MMP16

1.73e-0519912886759_DN
Drugformetanate

HSPA5 HSP90AA1 HSP90AA2P

2.02e-05101283CID000031099
DrugPu-3

HSP90AA1 HSP90AA2P HSP90AB1

2.77e-05111283CID000448965
Drug3-amino-5-chlorobenzoic acid

HSP90AA1 HSP90AA2P

3.14e-0521282CID010986726
Drugmonocillin III

HSP90AA1 HSP90AA2P

3.14e-0521282CID006478910
Drugpochonin A

HSP90AA1 HSP90AA2P

3.14e-0521282CID006478909
DrugPU-H71

HSP90AA1 HSP90AA2P

3.14e-0521282CID009549213
Drug9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine

HSP90AA1 HSP90AB1

3.14e-0521282DB02754
Drug1uyc

HSP90AA1 HSP90AA2P

3.14e-0521282CID000448969
DrugPU-9

HSP90AA1 HSP90AA2P

3.14e-0521282CID000448971
DrugP u 0

HSP90AA1 HSP90AA2P

3.14e-0521282CID000448974
Drug2qf6

HSP90AA1 HSP90AA2P

3.14e-0521282CID013373715
DrugGeldanamycin

HSP90AA1 HSP90AB1

3.14e-0521282DB02424
DrugCHEBI:42139

HSP90AA1 HSP90AA2P

3.14e-0521282CID011562562
Drug2qfo

HSP90AA1 HSP90AA2P

3.14e-0521282CID000600769
Drug3eko

HSP90AA1 HSP90AA2P

3.14e-0521282CID011160307
Drug8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE

HSP90AA1 HSP90AB1

3.14e-0521282DB07877
Drug1uyi

HSP90AA1 HSP90AA2P

3.14e-0521282CID005289232
Drug4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL

HSP90AA1 HSP90AB1

3.14e-0521282DB07594
DrugNSC683666

HSP90AA1 HSP90AA2P

3.14e-0521282CID005469153
DrugH 64

HSP90AA1 HSP90AA2P

3.14e-0521282CID006914564
DrugSureCN4151355

HSP90AA1 HSP90AA2P

3.14e-0521282CID015942101
DrugAC1L3HJJ

HP1BP3 HSP90AA1 HSP90AA2P

4.76e-05131283CID000089287
DrugAC1L85F0

IARS2 HSP90AA1 HSP90AA2P

4.76e-05131283CID000372766
Drug2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone

TMEM144 MATR3 KIF1B ITPRID2 PER2 FLOT1 HSP90AA1 CNTN1 HSP90AB1

8.44e-053201289ctd:C030370
Drugpochonin D

HSP90AA1 HSP90AA2P

9.37e-0531282CID006478913
Drugazaquinone

HSP90AA1 HSP90AA2P

9.37e-0531282CID000099132
Drugd 1 v

HSP90AA1 HSP90AA2P

9.37e-0531282CID000683940
DrugAC1MD0RC

HSP90AA1 HSP90AA2P

9.37e-0531282CID002829073
DrugHM-9

HSP90AA1 HSP90AA2P

9.37e-0531282CID000433437
DrugGlyoxylspermidine

HSP90AA1 HSP90AA2P

9.37e-0531282CID000133564
Druggeldanamycin; Down 200; 1uM; PC3; HT_HG-U133A

BRIP1 MCM4 CNTLN NEK9 THBS1 NRXN3 MVK

1.02e-0419012874452_DN
DrugTrimethobenzamide hydrochloride [554-92-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A

ABCC3 AMPD1 NAALAD2 CNPY4 NIPAL3 SKP2 HP1BP3

1.09e-0419212874180_UP
DrugAC1L1JAF

HSPA5 HSP90AA1 HSP90AA2P HSP90AB1

1.19e-04451284CID000004952
DrugSB 202190; Down 200; 1uM; PC3; HT_HG-U133A

TBC1D30 AGPAT3 SKP2 NRP1 MTHFD2L MMP16 MVK

1.20e-0419512877058_DN
DrugCisapride [81098-60-4]; Down 200; 8.6uM; PC3; HT_HG-U133A

ABCC3 DCAF15 SKP2 NRP1 THBS1 SENP2 WDR62

1.20e-0419512876706_DN
DrugNitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; MCF7; HT_HG-U133A

AMPD1 SFRP4 GRK4 CNPY4 NRP1 PYHIN1 SCN10A

1.20e-0419512874705_UP
DrugAnabasine [494-52-0]; Up 200; 24.6uM; MCF7; HT_HG-U133A

ABCC3 DCAF15 TMEM144 SFRP4 TBC1D30 THBS1 MMP16

1.24e-0419612876774_UP
DrugAminohippuric acid [61-78-9]; Up 200; 20.6uM; HL60; HT_HG-U133A

CCDC7 NRP1 CATSPERB REPS2 MMP16 SNRNP200 CNTN1

1.28e-0419712873076_UP
Drug3-Acetamidocoumarin [779-30-6]; Up 200; 19.6uM; PC3; HT_HG-U133A

TBC1D30 NIPAL3 NEK9 KRIT1 PYHIN1 PTPRB WDR62

1.32e-0419812874601_UP
DrugDoxycycline hydrochloride [10592-13-9]; Up 200; 8.4uM; HL60; HT_HG-U133A

NAALAD2 RNLS GRK4 GRB7 NIPAL3 PTPRB MMP16

1.32e-0419812872737_UP
DrugBuflomedil hydrochloride [35543-24-9]; Up 200; 11.6uM; PC3; HT_HG-U133A

NIPAL3 NEK9 ADAMTS12 TAS2R8 NRXN3 P2RX7 ST8SIA4

1.32e-0419812874258_UP
DrugHomatropine hydrobromide (R,S) [51-56-9]; Up 200; 11.2uM; PC3; HT_HG-U133A

HNRNPDL ABCC3 MCM4 SKP2 HP1BP3 ZNF43 MVK

1.32e-0419812871806_UP
DrugGalanthamine hydrobromide [1953-04-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

SFRP4 RNLS NEB SCN10A MMP16 SNRNP200 WDR62

1.36e-0419912872787_UP
DrugProcaine hydrochloride [51-05-8]; Up 200; 14.6uM; PC3; HT_HG-U133A

ABCC3 TBC1D30 CNPY4 THBS1 SCN10A MMP16 MYBPC3

1.40e-0420012876329_UP
DrugICI 182,780

ABCC3 GRB7 SKP2 THBS1 NOS2 HSP90AA1 HSP90AA2P HSP90AB1

1.56e-042721288CID000104741
Drugovalicin

SLA2 HSP90AA1 HSP90AA2P

1.84e-04201283CID000284995
DrugUM-272

KRIT1 PIK3C2A

1.87e-0441282CID000038088
DrugN-(5-methylisoxazol-3-yl)-2-(4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio)acetamide

HSP90AA1 HSP90AB1

1.87e-0441282ctd:C576667
Druguranyl chloride

HSP90AA1 HSP90AA2P

1.87e-0441282CID000082259
DrugTaylor D

KRIT1 MYBPC3

1.87e-0441282CID000394229
Drugmethoxyhydroquinone

HSP90AA1 HSP90AA2P

1.87e-0441282CID000069988
Drug11p110

HSP90AA1 HSP90AA2P

1.87e-0441282CID002382787
DiseaseDown syndrome (biomarker_via_orthology)

RPLP0 RPLP0P6

1.78e-0521252DOID:14250 (biomarker_via_orthology)
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNB FLNC

5.33e-0531252DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNB FLNC

5.33e-0531252DOID:0111190 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

FLNB BRIP1 CATSPERE GRB7 ADAR RHD THBS1 PER2 N4BP2 MACF1 DHX32 REPS2 NOS2 HSP90AA1

1.89e-04107412514C0006142
Diseaseretinitis pigmentosa (implicated_via_orthology)

PRPF8 USH2A SNRNP200

2.02e-04271253DOID:10584 (implicated_via_orthology)
DiseaseDepression, Postpartum

HP1BP3 PER2

3.69e-0471252C0221074
Diseaseretinitis pigmentosa (is_implicated_in)

PRPF8 USH2A SNRNP200

7.03e-04411253DOID:10584 (is_implicated_in)
Diseasecerebral amyloid deposition measurement

RNLS NRXN3 MMP16 CNTN1

7.26e-04951254EFO_0007707
DiseaseColorectal Carcinoma

ABCC3 FLNC AMPD1 SFRP4 CAPN6 P2RX7 ZNF43 ST8SIA4 SNRNP200 CNTN1

8.31e-0470212510C0009402
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

KIF1B PTPRZ1

1.35e-03131252DOID:332 (biomarker_via_orthology)
DiseasePneumoconiosis

CDH23 PTPRZ1

1.57e-03141252C0032273
DiseaseBagassosis

CDH23 PTPRZ1

1.57e-03141252C0004681
Diseaserevision of total hip arthroplasty

ICE1 ADAMTS12

1.57e-03141252EFO_0020973
DiseaseAsbestosis

NOS2 HSPA5

1.57e-03141252C0003949
DiseasePulmonary Fibrosis - from Asbestos Exposure

NOS2 HSPA5

1.57e-03141252C2930617
Diseaseneutrophil count

FLNB MYCBP2 GDAP2 LIN54 KIF1B CDH23 ADAR RRAGC TTLL12 ZNF12 SUPT5H MTHFD2L MVK USP47

2.19e-03138212514EFO_0004833
Diseaseessential hypertension (is_implicated_in)

RNLS GRK4

2.61e-03181252DOID:10825 (is_implicated_in)
DiseaseTourette syndrome, schizophrenia

DNAH10 MYO19

2.61e-03181252EFO_0004895, MONDO_0005090
Diseaseintrahepatic cholangiocarcinoma (is_marker_for)

HSP90AA1 HSP90AB1

2.90e-03191252DOID:4928 (is_marker_for)
DiseaseRetinitis pigmentosa

PRPF8 USH2A SNRNP200

3.86e-03741253cv:C0035334
Diseasecervical squamous cell carcinoma (is_marker_for)

BRIP1 ADAR

3.89e-03221252DOID:3744 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
KHPQGTEVKAITYSA

ZBTB8OS

136

Q8IWT0
QVLDTGKRKRHVPYS

CNPY4

66

Q8N129
AYIRKVLQHTTPKGF

CATSPERB

586

Q9H7T0
GQKPVIHTVLKRKVY

CATSPERE

156

Q5SY80
TNTVGKPTYKVLHAA

CCDC7

1361

Q96M83
SHTAVPTRVNREKYK

CNTLN

956

Q9NXG0
GATRTVPAHKYVLAV

BTBD6

146

Q96KE9
KYGLRGHVPITKSTA

CCDC171

956

Q6TFL3
IAQGPVKTYTHRRLK

AMPD1

251

P23109
VAQLHPLSGYSITKK

DHX32

646

Q7L7V1
SVPDHVGYAKVKITL

CDH23

436

Q9H251
LKSKVIAPGVIYDVH

ADAMTS12

461

P58397
GIHSKSLVPVYVKVR

ADNP2

846

Q6IQ32
TTALKKYVLENHPGT

HP1BP3

361

Q5SSJ5
QTSGAYVLNKVPVKH

RBM27

736

Q9P2N5
VPIGYKGSTFHRVIK

PPIH

56

O43447
VHSQVYRSSKVEKLP

QSER1

356

Q2KHR3
PVKKLLESRYHQIGS

HNRNPDL

286

O14979
VERKTISPGYAITIH

ABCC3

616

O15438
VRGKQHIQIPKLYTS

NOS2

686

P35228
AARFIIHTVGPKYKS

GDAP2

121

Q9NXN4
VNPRVSNVKSVYKTH

MCM4

401

P33991
PYVTTKTVGIEKLAH

SLC16A9

416

Q7RTY1
VVKKHSQFIGYPITL

HSP90AB1

201

P08238
VPHKRYLVSIKVQSA

PTPRB

1416

P23467
SASGVPYRVLEHTKK

NIPAL3

391

Q6P499
KSYTHIRRIVPGAVS

KLHL6

606

Q8WZ60
IQVPGSKFHYVRLVT

LIN54

351

Q6MZP7
VFGKPVRVHLSQKYK

MATR3

461

P43243
YALKSVKIPVRNHGI

LYSMD4

111

Q5XG99
FYKIRTIAPGKTHTA

NEK9

596

Q8TD19
AITKSHPQRSDVYKS

MTMR10

316

Q9NXD2
KLKPHVFTVGEQTYR

MYO19

101

Q96H55
IRPSSVVSKKGYLHF

KIF1B

1696

O60333
IGVTVKPEQKYVHFT

CFAP65

1286

Q6ZU64
IPGVDVKLHYNSKTL

KIAA1109

3876

Q2LD37
PHTRLGKLAVVVASY

KCNV1

61

Q6PIU1
KSEKVYTRHGVPISV

FLOT1

51

O75955
SVEYLPKVTGLHKVT

FLNB

316

O75369
IVKKHSQFIGYPITL

HSP90AA5P

36

Q58FG0
SYSSTIVHVGDKKPQ

PER2

671

O15055
IPGKKYVANTVFHSI

PCNX4

131

Q63HM2
PIVYSIKTKEIHGAI

OR51J1

291

Q9H342
HTNSVPGTVTKKGYV

PIK3C2A

816

O00443
ALHTKRPQVVTKYGT

CES4A

21

Q5XG92
TITVRYAPTEKGLHQ

FLNC

1821

Q14315
KRYISVVPSSFIGHL

NRXN3

821

Q9Y4C0
RVTKTYKRKNIEPTH

MACF1

3066

O94854
VYVKRKTNVLSPHTS

LPAR3

211

Q9UBY5
TKASPSNHKVIPVYV

KRIT1

646

O00522
SNHKVIPVYVGVNIK

KRIT1

651

O00522
NVTKKTTFIVHGFRP

LIPH

66

Q8WWY8
KKEPQISTTTHYNRI

PTPRZ1

456

P23471
SVPHSIINGYKRVLA

RPLP0

236

P05388
HVPATYQLGLTKSKR

ITPRID2

481

P28290
STKGTSKDPRHLQYV

GRB7

261

Q14451
SKIPKIYFGTRTHKQ

BRIP1

241

Q9BX63
LYVRPGKAHSVQVRK

OR6V1

256

Q8N148
QKGKVARLVSPVVYS

NRP1

701

O14786
SHVGTLRVKLRYQKP

NRP1

731

O14786
AQKSISQHYSKPRVT

PAF1

186

Q8N7H5
YQRKEPVISSVHTKV

P2RX7

51

Q99572
PVIRSHVYVGNISKK

ICE1

1931

Q9Y2F5
VNHPKVGRVSIYDSK

ADAR

1101

P55265
RHIPGVVEVTLSYKS

EBF4

311

Q9BQW3
VGPRYGISHVINTKT

FRMPD4

441

Q14CM0
KVTVTNPDTGRYVHK

CNTN1

756

Q12860
SGYPHTQENVSKLIK

GIMAP8

631

Q8ND71
IPKINILHKQTSGYI

PYHIN1

311

Q6K0P9
QTHTTPQIYTQLKGK

CASC2

51

Q8IU53
KPSVLSRVSHQVAYG

GBF1

1231

Q92538
DSKTSQVPVKHVYRV

KCTD5

146

Q9NXV2
IVKKHSQFIGYPITL

HSP90AA1

206

P07900
PVTKNTFRHYRVLGK

GRK4

181

P32298
LGKKVTHAVVTVPAY

HSPA5

161

P11021
RGYPKVVTQITVHSA

CAPN6

511

Q9Y6Q1
VVHTNTGKAPKLASY

DNAH10

846

Q8IVF4
KKSRSGRHVVFYPTL

CHID1

346

Q9BWS9
GQLRPKTYHTSLKVA

DCAF15

506

Q66K64
IVKKHSQLIGYPITL

HSP90AA2P

206

Q14568
TYHGKVVSSQDPRTK

SPOUT1

241

Q5T280
IITGLKPATKYVFHI

EPHA6

501

Q9UF33
LTYARFTGAPLKVHK

MTX1

176

Q13505
HGVKTTQFVPKQYRL

SENP2

261

Q9HC62
HGSTRSVAVTYKTKP

USH2A

1131

O75445
SVPHSIINGYKRVLA

RPLP0P6

236

Q8NHW5
VYVKSGSNRSHQPKK

SPDYA

16

Q5MJ70
RLHITVSKAYKVNPD

RRAGC

156

Q9HB90
YGKIIRVTLSKHQTV

PTBP2

401

Q9UKA9
SGREYNIPSVHVAKV

SLA2

76

Q9H6Q3
FTKNGRLATKYHTVP

TMEM126B

161

Q8IUX1
AGKKPLAHYSSLVRV

NBR1

106

Q14596
SVVKSSFKPGDVIHY

ST8SIA4

96

Q92187
RGHLVIKSASYKVVP

TANC1

716

Q9C0D5
YKVVKTGPSGHNIRS

MYCBP2

2591

O75592
AARKRAPYKTVIVHG

IARS2

641

Q9NSE4
QIKSVVAPEHVKGYI

SUPT5H

211

O00267
TKIRSYPVTEQRVKH

CKAP2L

316

Q8IYA6
YPVTEQRVKHTKPRT

CKAP2L

321

Q8IYA6
IETVQKETIHPRKSY

PRPF8

1606

Q6P2Q9
SHFTTIARPTIGNKK

SKP2

391

Q13309
SPAIRTNYIGHKTKD

THBS1

251

P07996
ITQRLLTHSGKKPYV

ZNF705A

131

Q6ZN79
GIHNPLNKIYITTKR

WASHC5

1021

Q12768
GKAFTVPSSLQKHVR

ZNF177

346

Q13360
KYHLLPRTKGFTTAV

AGPAT3

201

Q9NRZ7
SSLAHPQGKISKTYV

RHD

256

Q02161
PQGKISKTYVHSAVL

RHD

261

Q02161
HITYSIKNVTPKVGD

MMP16

131

P51512
LHGTKVQIPYLTTEK

REPS2

156

Q8NFH8
VAPQGISSIIKHYLK

RNLS

106

Q5VYX0
GSTFVPIIYIKDHSK

TMEM144

201

Q7Z5S9
YHQGKISSLKRSPAL

MVK

216

Q03426
SHRKPDIYINKRGTS

SCN10A

291

Q9Y5Y9
SYVIHAKIKAVQRSG

SFRP4

196

Q6FHJ7
SLQKVIPRRYGKSGH

ZNF679

106

Q8IYX0
TGHRVTYSPRKEKAL

USP47

1346

Q96K76
STLTNYKRIHTGEKP

ZNF716

281

A6NP11
HQVYIRADKGPVTSI

TBC1D30

656

Q9Y2I9
ITQCLLTHSGKKPYV

ZNF705G

131

A8MUZ8
HRESTPKVVSKYIES

TTLL12

441

Q14166
TVTIAHRYTPKEQLK

MTHFD2L

241

Q9H903
IITKHKRINTGEKPY

ZNF43

216

P17038
EKQGQVYTPKHIVRS

ZSWIM2

311

Q8NEG5
KKRSGHPRQDTYVST

WDR62

771

O43379
LPAHTVIIKGTQVYS

SNRNP200

821

O75643
HTKQIKLYATGSRDP

TAS2R8

211

Q9NYW2
SRKVVEHSNPAKYVS

TASOR2

811

Q5VWN6
GLTIQKRIHTEEKPY

ZNF355P

226

Q9NSJ1
SVGYHIIKPDVISKL

ZNF12

46

P17014
KLHYVVTEVQGPSIT

TRRAP

911

Q9Y4A5
KTIPNVIISHRYKAQ

TRRAP

996

Q9Y4A5
QGIKHSLQKVIPRTY

ZNF722

101

A0A1W2PQL4
YLHVSVESRGQPVKI

KIAA2013

506

Q8IYS2
IKPLKETTTSVRYHQ

NAALAD2

31

Q9Y3Q0
QVIKPNSKHFRTTVG

MYO5C

611

Q9NQX4
PVSQVVRKKTSYVGL

N4BP2

426

Q86UW6
PAYQVSKGHKIRLTV

MYBPC3

371

Q14896
VKKHLAQGSYTTLPE

NEB

5656

P20929
TAYKHAKTTELPQQR

NEB

6576

P20929