Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 MRGPRX1 FPR1 GPR82 OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	1.13e-08	884	72	17	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 OR52E1 OR2A5 OR11H12 OR8B2 OR11H2 OR8B3	3.86e-07	431	72	11	GO:0004984
GeneOntologyMolecularFunction	transporter activity	ATP6V1A ANO2 CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A SLC5A7 MTTP ABCC5 TRPV6 APOB SLC43A3 SLC4A5 ANKH TRPV5 SLC38A6	4.94e-07	1289	72	18	GO:0005215
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ATP6V1A ANO2 CNNM2 KCNC2 ATP13A1 SLC15A4 SCN10A SLC5A7 ABCC5 TRPV6 SLC4A5 ANKH TRPV5	2.75e-06	758	72	13	GO:0015318
GeneOntologyMolecularFunction	transmembrane transporter activity	ATP6V1A ANO2 CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A SLC5A7 ABCC5 TRPV6 SLC43A3 SLC4A5 ANKH TRPV5 SLC38A6	3.56e-06	1180	72	16	GO:0022857
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 MRGPRX1 FPR1 GPR82 OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	4.63e-06	1353	72	17	GO:0004888
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ATP6V1A CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A SLC5A7 TRPV6 SLC4A5 TRPV5	2.42e-05	664	72	11	GO:0008324
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ATP6V1A ANO2 CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A SLC5A7 TRPV6 SLC4A5 TRPV5	2.43e-05	793	72	12	GO:0015075
GeneOntologyMolecularFunction	ribosome binding	NOMO2 NEMF GCN1 NOMO3 NOMO1	7.31e-05	120	72	5	GO:0043022
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	ATP6V1A CNNM2 KCNC2 ATP13A1 SLC15A4 SCN10A SLC5A7 TRPV6 SLC4A5 TRPV5	8.05e-05	627	72	10	GO:0022890
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CNNM2 KCNC2 ATP13A1 SCN10A SLC5A7 TRPV6 SLC4A5 TRPV5	2.64e-04	465	72	8	GO:0046873
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC15A4 ABCC5 SLC43A3 SLC4A5 ANKH SLC38A6	6.58e-04	293	72	6	GO:0008514
GeneOntologyMolecularFunction	ribonucleoprotein complex binding	NOMO2 NEMF GCN1 NOMO3 NOMO1	8.89e-04	206	72	5	GO:0043021
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC15A4 ABCC5 ANKH	1.26e-03	59	72	3	GO:1901505
GeneOntologyMolecularFunction	monoatomic ion channel activity	ATP6V1A ANO2 KCNC2 CNGB3 SCN10A TRPV6 TRPV5	1.32e-03	459	72	7	GO:0005216
GeneOntologyMolecularFunction	monoatomic cation channel activity	ATP6V1A KCNC2 CNGB3 SCN10A TRPV6 TRPV5	1.48e-03	343	72	6	GO:0005261
GeneOntologyMolecularFunction	oligopeptide transmembrane transporter activity	SLC15A4 ABCC5	1.49e-03	16	72	2	GO:0035673
GeneOntologyMolecularFunction	active transmembrane transporter activity	ATP6V1A ATP13A1 SLC15A4 SLC5A7 ABCC5 SLC4A5 ANKH	1.64e-03	477	72	7	GO:0022804
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	KCNC2 SCN10A	1.68e-03	17	72	2	GO:0099508
GeneOntologyMolecularFunction	channel activity	ATP6V1A ANO2 KCNC2 CNGB3 SCN10A TRPV6 TRPV5	2.81e-03	525	72	7	GO:0015267
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	PIGN DPAGT1	2.83e-03	22	72	2	GO:0016780
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ATP6V1A ANO2 KCNC2 CNGB3 SCN10A TRPV6 TRPV5	2.84e-03	526	72	7	GO:0022803
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC15A4 SLC5A7 SLC38A6	3.36e-03	83	72	3	GO:0015101
GeneOntologyMolecularFunction	cholesterol transfer activity	MTTP APOB	3.36e-03	24	72	2	GO:0120020
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ANO2 ABCC5 SLC4A5 ANKH	3.40e-03	171	72	4	GO:0015103
GeneOntologyMolecularFunction	sterol transfer activity	MTTP APOB	3.65e-03	25	72	2	GO:0120015
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	ATP6V1A ATP13A1 SLC15A4 SLC5A7 SLC4A5	4.62e-03	301	72	5	GO:0022853
GeneOntologyMolecularFunction	purine nucleotide transmembrane transporter activity	ABCC5 ANKH	4.89e-03	29	72	2	GO:0015216
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	4.34e-09	547	71	14	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 SCN10A OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 OR8B3	9.52e-09	582	71	14	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 OR8B3	9.60e-09	485	71	13	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 OR8B3	2.40e-08	524	71	13	GO:0009593
GeneOntologyBiologicalProcess	sensory perception	OR1N1 OR5AC1 OR13D1 SFRP5 OR11H1 OR13C5 TAS1R3 CNGB3 SCN10A OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	9.39e-08	1072	71	17	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 SCN10A OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 OR8B3	1.39e-07	722	71	14	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 OR52E1 OR2A5 OR11H12 OR8B2 OR11H2 OR8B3	2.48e-07	432	71	11	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 OR52E1 OR2A5 OR11H12 OR8B2 OR11H2 OR8B3	5.15e-07	465	71	11	GO:0007608
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	3.23e-06	9	71	3	GO:0160063
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 MRGPRX1 FPR1 GPR82 OR52E1 OR2A5 TAS2R40 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	3.69e-06	1395	71	17	GO:0007186
GeneOntologyBiologicalProcess	protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	1.64e-04	31	71	3	GO:0045048
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	ATP6V1A ANO2 CNNM2 KCNC2 ATP13A1 SLC15A4 SCN10A ABCC5 TRPV6 SLC4A5 ANKH TRPV5	1.68e-04	1017	71	12	GO:0098660
GeneOntologyBiologicalProcess	negative regulation of nodal signaling pathway	NOMO3 NOMO1	2.43e-04	7	71	2	GO:1900108
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	ATP6V1A CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A ABCC5 TRPV6 SLC4A5 TRPV5	3.53e-04	942	71	11	GO:0098655
GeneOntologyBiologicalProcess	organic anion transport	SLC15A4 MTTP ABCC5 PLA2G4A SLC43A3 SLC4A5 ANKH SLC38A6	3.83e-04	515	71	8	GO:0015711
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	ATP6V1A ANO2 CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A ABCC5 TRPV6 SLC4A5 TRPV5	3.90e-04	1115	71	12	GO:0034220
GeneOntologyBiologicalProcess	regulation of nodal signaling pathway	NOMO3 NOMO1	4.14e-04	9	71	2	GO:1900107
GeneOntologyBiologicalProcess	lipoprotein biosynthetic process	PIGN ZDHHC6 MTTP APOB	4.91e-04	106	71	4	GO:0042158
GeneOntologyBiologicalProcess	determination of left/right asymmetry in lateral mesoderm	NOMO3 NOMO1	5.16e-04	10	71	2	GO:0003140
GeneOntologyBiologicalProcess	monoatomic cation transport	ATP6V1A CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A SLC5A7 ABCC5 TRPV6 SLC4A5 TRPV5	5.44e-04	1157	71	12	GO:0006812
GeneOntologyBiologicalProcess	protein insertion into membrane	NOMO2 NOMO3 NOMO1	6.82e-04	50	71	3	GO:0051205
GeneOntologyBiologicalProcess	monoatomic ion transport	ATP6V1A ANO2 CNNM2 KCNC2 ATP13A1 SLC15A4 CNGB3 SCN10A SLC5A7 ABCC5 TRPV6 SLC4A5 TRPV5	7.41e-04	1374	71	13	GO:0006811
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO2 NOMO3 NOMO1	3.24e-06	9	72	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO2 NOMO3 NOMO1	1.39e-05	14	72	3	GO:0072379
Domain	DUF2012	NOMO2 NOMO3 NOMO1	2.01e-07	4	70	3	PF09430
Domain	DUF2012	NOMO2 NOMO3 NOMO1	2.01e-07	4	70	3	IPR019008
Domain	GPCR_Rhodpsn_7TM	OR1N1 OR13D1 OR11H1 OR13C5 MRGPRX1 FPR1 GPR82 OR2A5 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	1.05e-06	670	70	13	IPR017452
Domain	G_PROTEIN_RECEP_F1_2	OR1N1 OR13D1 OR11H1 OR13C5 MRGPRX1 FPR1 GPR82 OR2A5 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	1.48e-06	691	70	13	PS50262
Domain	GPCR_Rhodpsn	OR1N1 OR13D1 OR11H1 OR13C5 MRGPRX1 FPR1 GPR82 OR2A5 OR11H12 OR8B2 OR11H2 VN1R1 OR8B3	1.50e-06	692	70	13	IPR000276
Domain	Carb-bd-like_fold	NOMO2 NOMO3 NOMO1	2.79e-06	8	70	3	IPR013784
Domain	G_PROTEIN_RECEP_F1_1	OR1N1 OR13D1 OR11H1 OR13C5 MRGPRX1 FPR1 GPR82 OR2A5 OR11H12 OR8B2 VN1R1 OR8B3	8.14e-06	685	70	12	PS00237
Domain	Vitellinogen_b-sht_N	MTTP APOB	1.38e-05	2	70	2	IPR015816
Domain	Lipid_transp_b-sht_shell	MTTP APOB	1.38e-05	2	70	2	IPR015819
Domain	LPD_N	MTTP APOB	1.38e-05	2	70	2	SM00638
Domain	Lipid_transpt_N	MTTP APOB	1.38e-05	2	70	2	IPR001747
Domain	TRPV5/TRPV6	TRPV6 TRPV5	1.38e-05	2	70	2	IPR008344
Domain	-	MTTP APOB	1.38e-05	2	70	2	2.30.230.10
Domain	-	MTTP APOB	1.38e-05	2	70	2	1.25.10.20
Domain	VITELLOGENIN	MTTP APOB	1.38e-05	2	70	2	PS51211
Domain	Vitellogenin_N	MTTP APOB	1.38e-05	2	70	2	PF01347
Domain	CarboxyPept_regulatory_dom	NOMO2 NOMO3 NOMO1	1.40e-05	13	70	3	IPR014766
Domain	-	NOMO2 NOMO3 NOMO1	1.40e-05	13	70	3	2.60.40.1120
Domain	Olfact_rcpt	OR1N1 OR13D1 OR11H1 OR13C5 OR2A5 OR11H12 OR8B2 OR11H2 OR8B3	1.55e-05	393	70	9	IPR000725
Domain	CarboxyPept-like_regulatory	NOMO2 NOMO3 NOMO1	3.30e-05	17	70	3	IPR008969
Domain	7tm_1	OR1N1 OR13D1 OR11H1 OR13C5 MRGPRX1 FPR1 GPR82 OR2A5 OR11H12 OR8B2 OR8B3	4.04e-05	677	70	11	PF00001
Domain	Vitellinogen_superhlx	MTTP APOB	4.14e-05	3	70	2	IPR011030
Domain	Ion_trans_dom	KCNC2 CNGB3 SCN10A TRPV6 TRPV5	6.84e-05	114	70	5	IPR005821
Domain	Ion_trans	KCNC2 CNGB3 SCN10A TRPV6 TRPV5	6.84e-05	114	70	5	PF00520
Domain	MAC_perforin	BRINP3 ASTN1	6.11e-04	10	70	2	IPR001862
Domain	TRP_channel	TRPV6 TRPV5	7.45e-04	11	70	2	IPR004729
Domain	-	CNNM2 CNGB3 GGCX	7.73e-04	48	70	3	2.60.120.10
Domain	MACPF	BRINP3 ASTN1	8.92e-04	12	70	2	SM00457
Domain	MACPF	BRINP3 ASTN1	8.92e-04	12	70	2	IPR020864
Domain	RmlC-like_jellyroll	CNNM2 CNGB3 GGCX	9.23e-04	51	70	3	IPR014710
Domain	HEAT_REPEAT	MROH2A HEATR5B GCN1	2.31e-03	70	70	3	PS50077
Domain	DAPIN	NLRP11 NLRP5	3.05e-03	22	70	2	PS50824
Domain	PYRIN	NLRP11 NLRP5	3.05e-03	22	70	2	PF02758
Domain	DAPIN	NLRP11 NLRP5	3.05e-03	22	70	2	IPR004020
Domain	PYRIN	NLRP11 NLRP5	3.05e-03	22	70	2	SM01289
Domain	NACHT	NLRP11 NLRP5	3.33e-03	23	70	2	PS50837
Domain	NACHT_NTPase	NLRP11 NLRP5	3.33e-03	23	70	2	IPR007111
Pathway	REACTOME_SENSORY_PERCEPTION	OR1N1 ANO2 OR5AC1 OR13D1 OR11H1 OR13C5 TAS1R3 OR52E1 APOB OR2A5 TAS2R40 OR8B2 OR11H2 OR8B3	7.64e-08	636	54	14	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1N1 ANO2 OR5AC1 OR13D1 OR11H1 OR13C5 OR52E1 OR2A5 OR8B2 OR11H2 OR8B3	4.05e-07	417	54	11	M4072
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ATP6V1A ANO2 ATP13A1 SLC15A4 SLC5A7 MTTP ABCC5 TRPV6 APOB SLC4A5 ANKH TRPV5	7.75e-06	681	54	12	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ATP6V1A ANO2 ATP13A1 SLC15A4 SLC5A7 MTTP ABCC5 TRPV6 APOB SLC4A5 ANKH TRPV5	1.70e-05	736	54	12	M27287
Pathway	REACTOME_VLDL_ASSEMBLY	MTTP APOB	1.43e-04	5	54	2	M27760
Pathway	REACTOME_VLDL_ASSEMBLY	MTTP APOB	1.43e-04	5	54	2	MM15505
Pathway	REACTOME_LDL_REMODELING	MTTP APOB	2.14e-04	6	54	2	M42520
Pathway	WP_GPCRS_ODORANT	TAS1R3 MRGPRX1 GPR82 OR8B2 OR8B3	3.27e-04	157	54	5	MM15872
Pathway	REACTOME_CHYLOMICRON_ASSEMBLY	MTTP APOB	5.10e-04	9	54	2	MM15558
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP6V1A ANO2 ATP13A1 TRPV6 TRPV5	5.53e-04	176	54	5	MM15718
Pathway	REACTOME_CHYLOMICRON_ASSEMBLY	MTTP APOB	6.35e-04	10	54	2	M27838
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP6V1A ANO2 ATP13A1 TRPV6 TRPV5	6.60e-04	183	54	5	M997
Pathway	REACTOME_SENSORY_PERCEPTION	TAS1R3 APOB TAS2R40 OR8B2 OR8B3	7.81e-04	190	54	5	MM15687
Pathway	WP_FEMALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM	MTTP APOB	1.27e-03	14	54	2	M48059
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO2 NOMO3 NOMO1	8.51e-09	3	72	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO2 NOMO3 NOMO1	8.51e-09	3	72	3	25576386
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO2 NOMO3 NOMO1	3.40e-08	4	72	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO2 NOMO3 NOMO1	3.40e-08	4	72	3	9267806
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO2 NOMO3 NOMO1	4.73e-07	8	72	3	15257293
Pubmed	Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.	CNNM2 TRPV6 TRPV5	4.73e-07	8	72	3	33859252
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO2 NOMO3 NOMO1	7.08e-07	9	72	3	36261522
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO2 NOMO3 NOMO1	1.39e-06	11	72	3	32820719
Pubmed	Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.	TRPV6 TRPV5	4.23e-06	2	72	2	20405023
Pubmed	Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects.	MTTP APOB	4.23e-06	2	72	2	27487388
Pubmed	Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.	TRPV6 TRPV5	4.23e-06	2	72	2	20178461
Pubmed	A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion.	MTTP APOB	4.23e-06	2	72	2	10713055
Pubmed	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.	TRPV6 TRPV5	4.23e-06	2	72	2	22354706
Pubmed	Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.	TRPV6 TRPV5	4.23e-06	2	72	2	16564089
Pubmed	A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.	TRPV6 TRPV5	4.23e-06	2	72	2	11846401
Pubmed	First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.	TRPV6 TRPV5	4.23e-06	2	72	2	25164318
Pubmed	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.	TRPV6 TRPV5	4.23e-06	2	72	2	19295174
Pubmed	Identification of patients with abetalipoproteinemia and homozygous familial hypobetalipoproteinemia in Tunisia.	MTTP APOB	4.23e-06	2	72	2	19056372
Pubmed	Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.	TRPV6 TRPV5	4.23e-06	2	72	2	23968883
Pubmed	Novel mutations in abetalipoproteinaemia and homozygous familial hypobetalipoproteinaemia.	MTTP APOB	4.23e-06	2	72	2	18027103
Pubmed	Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.	TRPV6 TRPV5	4.23e-06	2	72	2	12390878
Pubmed	Human placenta secretes apolipoprotein B-100-containing lipoproteins.	MTTP APOB	4.23e-06	2	72	2	15504742
Pubmed	Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.	TRPV6 TRPV5	4.23e-06	2	72	2	12574114
Pubmed	Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.	TRPV6 TRPV5	4.23e-06	2	72	2	24761864
Pubmed	TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons.	ANO2 SCN10A	4.23e-06	2	72	2	30843875
Pubmed	Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.	TRPV6 TRPV5	4.23e-06	2	72	2	11549322
Pubmed	[TRPV5 and TRPV6 calcium channels in human T cells].	TRPV6 TRPV5	4.23e-06	2	72	2	19140341
Pubmed	TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.	TRPV6 TRPV5	4.23e-06	2	72	2	30916584
Pubmed	Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.	TRPV6 TRPV5	4.23e-06	2	72	2	15123711
Pubmed	Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia.	MTTP APOB	4.23e-06	2	72	2	24842304
Pubmed	Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.	TRPV6 TRPV5	4.23e-06	2	72	2	12077127
Pubmed	Relationship between Amphipathic β Structures in the β1 Domain of Apolipoprotein B and the Properties of the Secreted Lipoprotein Particles in McA-RH7777 Cells.	MTTP APOB	4.23e-06	2	72	2	28702990
Pubmed	Hypobetalipoproteinemia with an apparently recessive inheritance due to a "de novo" mutation of apolipoprotein B.	MTTP APOB	4.23e-06	2	72	2	14732481
Pubmed	Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.	TRPV6 TRPV5	4.23e-06	2	72	2	16565876
Pubmed	Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.	TRPV6 TRPV5	4.23e-06	2	72	2	11719848
Pubmed	Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.	TRPV6 TRPV5	4.23e-06	2	72	2	17233615
Pubmed	Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein B lipoproteins from liver cells.	MTTP APOB	4.23e-06	2	72	2	11358959
Pubmed	[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].	TRPV6 TRPV5	4.23e-06	2	72	2	24592736
Pubmed	A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase.	MTTP APOB	4.23e-06	2	72	2	9915855
Pubmed	Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells.	MTTP APOB	4.23e-06	2	72	2	15795421
Pubmed	Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.	TRPV6 TRPV5	4.23e-06	2	72	2	16705151
Pubmed	Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells.	MTTP APOB	4.23e-06	2	72	2	17690102
Pubmed	Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.	TRPV6 TRPV5	1.27e-05	3	72	2	17200157
Pubmed	Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition.	MTTP APOB	1.27e-05	3	72	2	18502767
Pubmed	Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.	MTTP APOB	1.27e-05	3	72	2	38211723
Pubmed	Complex genetic architecture in severe hypobetalipoproteinemia.	MTTP APOB	1.27e-05	3	72	2	29540175
Pubmed	Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function.	MTTP APOB	1.27e-05	3	72	2	26224785
Pubmed	A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.	TRPV6 TRPV5	1.27e-05	3	72	2	27291418
Pubmed	ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes.	MTTP APOB	1.27e-05	3	72	2	19020660
Pubmed	Lowering plasma cholesterol levels halts progression of aortic valve disease in mice.	MTTP APOB	1.27e-05	3	72	2	19433756
Pubmed	Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.	MTTP APOB	1.27e-05	3	72	2	19026012
Pubmed	Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.	TRPV6 TRPV5	1.27e-05	3	72	2	19922080
Pubmed	Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development.	MTTP APOB	1.27e-05	3	72	2	10553000
Pubmed	Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.	TRPV6 TRPV5	1.27e-05	3	72	2	16763551
Pubmed	Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.	TRPV6 TRPV5	1.27e-05	3	72	2	16380433
Pubmed	Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice.	MTTP APOB	1.27e-05	3	72	2	21562077
Pubmed	Vascular function during prolonged progression and regression of atherosclerosis in mice.	MTTP APOB	1.27e-05	3	72	2	23307875
Pubmed	Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.	TRPV6 TRPV5	1.27e-05	3	72	2	16354700
Pubmed	Microsomal triglyceride transfer protein expression during mouse development.	MTTP APOB	1.27e-05	3	72	2	10744773
Pubmed	Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion.	MTTP APOB	1.27e-05	3	72	2	12628954
Pubmed	Secretion of atherogenic risk factor apolipoprotein B-100 is increased by a potential mechanism of JNK/PKC-mediated insulin resistance in liver cells.	MTTP APOB	1.27e-05	3	72	2	17647275
Pubmed	Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis.	MTTP APOB	1.27e-05	3	72	2	24586211
Pubmed	The human olfactory receptor gene family.	OR1N1 OR5AC1 OR13D1 OR11H1 OR13C5 OR8B2 OR11H2 OR8B3	1.63e-05	541	72	8	14983052
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	ATP6V1A VWA8 NOMO2 NOMO3 NOMO1	1.87e-05	156	72	5	30409884
Pubmed	Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.	MTTP APOB	2.53e-05	4	72	2	18645210
Pubmed	Novel missense MTTP gene mutations causing abetalipoproteinemia.	MTTP APOB	2.53e-05	4	72	2	25108285
Pubmed	Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.	MTTP APOB	2.53e-05	4	72	2	25474352
Pubmed	Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques.	MTTP APOB	2.53e-05	4	72	2	21339485
Pubmed	Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.	MTTP APOB	2.53e-05	4	72	2	28062492
Pubmed	Molecular analysis of APOB, SAR1B, ANGPTL3, and MTTP in patients with primary hypocholesterolemia in a clinical laboratory setting: Evidence supporting polygenicity in mutation-negative patients.	MTTP APOB	2.53e-05	4	72	2	30782561
Pubmed	ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice.	MTTP APOB	2.53e-05	4	72	2	18519977
Pubmed	Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.	TRPV6 TRPV5	2.53e-05	4	72	2	12660155
Pubmed	Association between shear stress and platelet-derived transforming growth factor-β1 release and activation in animal models of aortic valve stenosis.	MTTP APOB	2.53e-05	4	72	2	24903096
Pubmed	miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.	MTTP APOB	2.53e-05	4	72	2	25201910
Pubmed	The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis.	MTTP APOB	2.53e-05	4	72	2	7741021
Pubmed	Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes.	MTTP APOB	2.53e-05	4	72	2	18369455
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	NOMO2 NOMO3 NOMO1	3.67e-05	31	72	3	19136429
Pubmed	Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression.	MTTP APOB	4.21e-05	5	72	2	25765938
Pubmed	Role and regulation of TRP channels in neutrophil granulocytes.	TRPV6 TRPV5	4.21e-05	5	72	2	12765698
Pubmed	Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).	TRPV6 TRPV5	4.21e-05	5	72	2	22407925
Pubmed	Characterization of lipoproteins in human placenta and fetal circulation as well as gestational changes in lipoprotein assembly and secretion in human and mouse placentas.	MTTP APOB	4.21e-05	5	72	2	37315736
Pubmed	Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation.	MTTP APOB	4.21e-05	5	72	2	12072432
Pubmed	An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.	NOMO2 NOMO3 NOMO1	4.44e-05	33	72	3	30783098
Pubmed	Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state.	MTTP APOB	6.31e-05	6	72	2	9694898
Pubmed	FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.	MTTP APOB	6.31e-05	6	72	2	18497885
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR1N1 OR5AC1 OR13D1 OR2A5 OR8B2 OR8B3	7.58e-05	340	72	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR1N1 OR5AC1 OR13D1 OR2A5 OR8B2 OR8B3	7.58e-05	340	72	6	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR1N1 OR5AC1 OR13D1 OR2A5 OR8B2 OR8B3	7.96e-05	343	72	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR1N1 OR5AC1 OR13D1 OR2A5 OR8B2 OR8B3	8.35e-05	346	72	6	14611657
Pubmed	Genetic polymorphisms and lipoprotein responses to diets.	MTTP APOB	8.82e-05	7	72	2	12691171
Pubmed	Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.	MTTP APOB	8.82e-05	7	72	2	16380418
Pubmed	Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.	MTTP APOB	1.17e-04	8	72	2	17784784
Pubmed	Identification of G protein-coupled receptor genes from the human genome sequence.	MRGPRX1 GPR82 VN1R1	1.21e-04	46	72	3	12044878
Pubmed	Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.	MRGPRX1 SCN10A	1.51e-04	9	72	2	30886406
Pubmed	Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.	MRGPRX1 SCN10A	1.88e-04	10	72	2	33098765
Pubmed	Nutrigenetics: links between genetic background and response to Mediterranean-type diets.	MTTP APOB	2.30e-04	11	72	2	19689828
Pubmed	Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.	TAS1R3 FPR1	2.75e-04	12	72	2	32294408
Pubmed	Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.	PLA2G4A NOMO3 NOMO1	2.95e-04	62	72	3	15862967
Pubmed	Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.	NOMO2 NOMO3 NOMO1	3.09e-04	63	72	3	31266804
Pubmed	The environmental and genetic evidence for the association of hyperlipidemia and hypertension.	MTTP APOB	3.25e-04	13	72	2	19155782
GeneFamily	Olfactory receptors, family 11	OR11H1 OR11H12 OR11H2	3.82e-05	23	52	3	159
GeneFamily	Olfactory receptors, family 13	OR13D1 OR13C5	1.97e-03	23	52	2	162
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP11 NLRP5	2.33e-03	25	52	2	994
GeneFamily	NLR family	NLRP11 NLRP5	2.33e-03	25	52	2	666
GeneFamily	Transient receptor potential cation channels	TRPV6 TRPV5	2.92e-03	28	52	2	249
GeneFamily	Solute carriers	SLC15A4 SLC5A7 SLC43A3 SLC4A5 SLC38A6	5.43e-03	395	52	5	752
GeneFamily	Olfactory receptors, family 8	OR8B2 OR8B3	8.75e-03	49	52	2	155
Disease	myelodysplastic syndrome	PLA2G4A TAF2	2.19e-04	10	66	2	EFO_0000198
Disease	familial hypercholesterolemia (is_implicated_in)	MTTP APOB	2.19e-04	10	66	2	DOID:13810 (is_implicated_in)
Disease	Myasthenic Syndromes, Congenital, Slow Channel	DPAGT1 SLC5A7	5.79e-04	16	66	2	C0751885
Disease	Congenital Myasthenic Syndromes, Postsynaptic	DPAGT1 SLC5A7	6.56e-04	17	66	2	C0751883
Disease	amino acid measurement	MPP2 PIGN ANO2 PLA2G4A APPL1 OR8B2 OR8B3	7.89e-04	678	66	7	EFO_0005134
Disease	Congenital Myasthenic Syndromes, Presynaptic	DPAGT1 SLC5A7	8.22e-04	19	66	2	C0751884
Disease	cerebral infarction (is_marker_for)	BRINP3 APOB	8.22e-04	19	66	2	DOID:3526 (is_marker_for)
Disease	Myasthenic Syndromes, Congenital	DPAGT1 SLC5A7	1.32e-03	24	66	2	C0751882
Disease	alpha-linolenic acid measurement	SFRP5 NLRP5	1.43e-03	25	66	2	EFO_0007759
Disease	anxiety measurement	CNNM2 TRPV6 TRPV5	1.85e-03	108	66	3	EFO_0009863
Disease	basophil percentage of leukocytes	KIAA0930 SLC15A4 ZDHHC6 ABCC5	2.17e-03	243	66	4	EFO_0007992

Protein segments in the cluster

Peptide	Gene	Start	Entry
FMKRLPMNYFLNTST	BRINP3	326	Q76B58
IAASQFNVPMLYFMG	AKAP4	781	Q5JQC9
SVSQGFRMLFYTMKP	AGMO	11	Q6ZNB7
QMATFAINYKGPPFM	ATP13A1	1111	Q9HD20
FQMPYKGMTTVDDFF	DPYSL3	76	Q14195
MHRFYMIQSFTQFPG	CCNT1	66	O60563
RFPGYLMNFASILFM	ANO2	531	Q9NQ90
LPMNQTLFGEMFFGY	ASTN1	726	O14525
FSNLSPGQYYFKPMM	NOMO3	916	P69849
MLTFYMPAFFSFMTH	OR52E1	246	Q8NGJ3
FSNLSPGQYYFKPMM	NOMO2	916	Q5JPE7
HTPMYMFLGNFSFLE	OR11H2	71	Q8NH07
FGMYYSLAMAKQKLP	KCNC2	476	Q96PR1
SAMPFMSIYFLKGFQ	GPR82	66	Q96P67
KNFLPPSYLMMGFSF	NEMF	641	O60524
PSYLMMGFSFLFKVD	NEMF	646	O60524
SNLDYMFFKFPRMSA	NLRP11	1006	P59045
LGYMQAQISFFKMGS	APPL1	201	Q9UKG1
SVAARMAQKMSFGFY	KIAA0930	221	Q6ICG6
FSKTMLLFFMPQVFN	DPAGT1	271	Q9H3H5
FFNGYSDLMSKMLSA	MTTP	706	P55157
KYGKMFFPNLTAYMS	NME5	61	P56597
FSNLSPGQYYFKPMM	NOMO1	916	Q15155
YIMMFNYLPITFGDK	GCN1	1756	Q92616
GMFSYVFFLPVREMQ	NLRP5	311	P59047
NVFVPMKYMLKYFGA	MPP2	61	Q14168
FCGTIFLMYMKPKSQ	OR13C5	251	Q8NGS8
LCYSSVFTPKMLMNF	OR8B3	71	Q8NGG8
FFGSAIVMYMAPKSR	OR2A5	251	Q96R48
MLSMAKCATQFYFFG	OR5AC1	91	P0C628
VAYMQPKANAPSFFM	PAN3	431	Q58A45
LGSAVFILFYPAMMF	ABCC5	321	O15440
ESYGGMPFFQAQKMF	CCSER2	636	Q9H7U1
EMSAFGYVFPKAVSM	APOB	3266	P04114
VPSFGEAMAYFAMVK	CENPB	541	P07199
AFYEKMGRMLGSAFP	HEATR5B	121	Q9P2D3
YSLMKFFTGPMSDFK	ANKH	56	Q9HCJ1
EYMKYGFFLLQMSPK	CCDC38	216	Q502W7
PKSMQSAIMGLFFFF	SLC15A4	481	Q8N697
TVIMMPFQFAGGSFK	COL5A3	441	P25940
HTPMYMFLGNFSFLE	OR11H1	71	Q8NG94
HTPMYMFLGNFSFLE	OR11H12	71	B2RN74
LCYSSVFTPKMLMNF	OR8B2	71	Q96RD0
MAKYGTFMAPDLFGS	PLA2G4A	356	P47712
PMYFFLANLSFVDMG	OR1N1	56	Q8NGS0
ILFYGSALFMYMKPK	OR13D1	281	Q8NGV5
RSYPKELMKFFFSQM	MROH2A	381	A6NES4
MFKNMTPSPFLRFYL	MRPS25	66	P82663
FFAKPMRSKGYVTML	SLC5A7	101	Q9GZV3
MVNLVFFYNMGIFVP	TAS2R40	191	P59535
MKFAVKFMFSYPCSL	SFRP5	291	Q5T4F7
FMSFQSYFLQKTMPV	TAF2	741	Q6P1X5
FFNSCLNPMLYVFMG	FPR1	291	P21462
ARKAVTMMFFSNFPF	SLC38A6	351	Q8IZM9
LGSFMNNFMTFPTGY	SLC43A3	76	Q8NBI5
KLDYFSMMFIPVALF	MT-ND5	81	P03915
KILYPVMMFSYFAGL	MRGPRX1	96	Q96LB2
VMMFSYFAGLSFLSA	MRGPRX1	101	Q96LB2
FFGFNPMFRANRMLK	CNGB3	316	Q9NQW8
FFMMMTFPASYPVSK	CNNM2	381	Q9H8M5
VMILYNYFNAMFVGP	ZDHHC6	66	Q9H6R6
MVTGKFFSFFLMPQV	TAS1R3	151	Q7RTX0
IGMFSYVMLASSPLF	GGCX	296	P38435
MSVDPMTYEAQFFGF	MIS12	1	Q9H081
LVMFIYSIFGMSSFP	SCN10A	1616	Q9Y5Y9
AVLYFSPDFMSLGFM	VN1R1	221	Q9GZP7
MYFARGFQMLGPFTI	TRPV6	506	Q9H1D0
MIGAFKYYPINMDFK	SLC4A5	656	Q9BY07
FCPFYKTVGMLSNMI	ATP6V1A	531	P38606
YCFLTVFSPFMMGAL	PIGN	816	O95427
FMYLGKIMTAPSSFE	ZBTB1	81	Q9Y2K1
FLAMPFNSLVNMAYT	TMEM187	51	Q14656
ALVSYTRFMGFMKPG	XKR5	156	Q6UX68
ASLYFMNMTGKSGFF	VWA8	1136	A3KMH1
MYFTRGFQMLGPFTI	TRPV5	466	Q9NQA5