Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol phospholipase C activity

PLCG2 PLCE1

3.71e-0426222GO:0004435
GeneOntologyMolecularFunctionphospholipase C activity

PLCG2 PLCE1

4.62e-0429222GO:0004629
GeneOntologyMolecularFunctionaminopeptidase activity

CTSH DPP9

1.02e-0343222GO:0004177
GeneOntologyCellularComponentalveolar lamellar body

CTSH ABCA3

4.73e-0510222GO:0097208
GeneOntologyCellularComponentlamellar body

CTSH ABCA3

2.19e-0421222GO:0042599
HumanPhenoInterstitial pneumonitis

RAG1 ABCA3 PLCG2

6.67e-0617123HP:0006515
HumanPhenoAbnormal pulmonary interstitial morphology

NUP107 RAG1 ABCA3 PLCG2 DPP9

1.96e-05161125HP:0006530
HumanPhenoFever

NUP107 KLHL7 RAG1 TRANK1 PLCE1 DPP9

2.11e-04431126HP:0001945
HumanPhenoSleep paralysis

CTSH TRANK1

2.27e-0410122HP:0025233
HumanPhenoREM parasomnia

CTSH TRANK1

2.27e-0410122HP:5200299
HumanPhenoAbnormal hypnagogia

CTSH TRANK1

2.27e-0410122HP:5200296
HumanPhenoHypnagogic hallucination

CTSH TRANK1

2.27e-0410122HP:0002519
HumanPhenoSlurred speech

CTSH TRANK1 DPP9

2.32e-0454123HP:0001350
HumanPhenoEdema

NUP107 KLHL7 RAG1 ABCA3 PLCG2 BUB1 PLCE1

3.76e-04699127HP:0000969
HumanPhenoReticular pattern on pulmonary HRCT

ABCA3 DPP9

4.56e-0414122HP:0025390
HumanPhenoHoneycomb lung

ABCA3 DPP9

4.56e-0414122HP:0025175
HumanPhenoOrthodeoxia

ABCA3 DPP9

4.56e-0414122HP:0033367
HumanPhenoUsual interstitial pneumonia

ABCA3 DPP9

5.25e-0415122HP:0031950
HumanPhenoSubpleural honeycombing

ABCA3 DPP9

5.99e-0416122HP:0031631
HumanPhenoAbnormal subpleural morphology

ABCA3 DPP9

6.78e-0417122HP:0031630
HumanPhenoPulmonary fibrosis

NUP107 ABCA3 DPP9

6.88e-0478123HP:0002206
MousePhenodecreased CD8-positive, naive alpha-beta T cell number

CLOCK RAG1 PLCG2

3.81e-0552183MP:0013435
MousePhenoimpaired natural killer cell mediated cytotoxicity

RAG1 CD226 PLCG2

7.45e-0565183MP:0005070
MousePhenoabnormal CD8-positive, naive alpha-beta T cell number

CLOCK RAG1 PLCG2

8.16e-0567183MP:0013434
MousePhenoabnormal natural killer cell mediated cytotoxicity

RAG1 CD226 PLCG2

9.70e-0571183MP:0011719
MousePhenoabnormal incidence of induced tumors

RAG1 CD226 BUB1 PLCE1

3.32e-04269184MP:0013151
MousePhenoabnormal NK cell physiology

RAG1 CD226 PLCG2

3.36e-04108183MP:0010766
DomainPIPLC_Y_DOMAIN

PLCG2 PLCE1

1.25e-0415212PS50008
DomainPI-PLC_fam

PLCG2 PLCE1

1.25e-0415212IPR001192
DomainPLC_EF-hand-like

PLCG2 PLCE1

1.25e-0415212IPR015359
DomainPI-PLC-Y

PLCG2 PLCE1

1.25e-0415212PF00387
DomainPLipase_C_Pinositol-sp_Y

PLCG2 PLCE1

1.25e-0415212IPR001711
DomainEF-hand_like

PLCG2 PLCE1

1.25e-0415212PF09279
DomainPLCYc

PLCG2 PLCE1

1.25e-0415212SM00149
DomainPI-PLC-X

PLCG2 PLCE1

1.82e-0418212PF00388
DomainPLCXc

PLCG2 PLCE1

1.82e-0418212SM00148
DomainPIPLC_X_DOMAIN

PLCG2 PLCE1

2.04e-0419212PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCG2 PLCE1

2.04e-0419212IPR000909
Domain-

PLCG2 PLCE1

3.56e-04252123.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

PLCG2 PLCE1

3.56e-0425212IPR017946
DomainC2

PLCG2 PLCE1

9.40e-03131212PF00168
DomainC2

PLCG2 PLCE1

1.02e-02137212SM00239
DomainC2

PLCG2 PLCE1

1.10e-02142212PS50004
Domain-

PLCG2 PLCE1

1.19e-021482122.60.40.150
Pubmed

Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.

RAG1 CD226 CD80

1.23e-08822327034402
Pubmed

Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression.

RAG1 CD80

3.82e-07222217549473
Pubmed

Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.

RAG1 PLCG2

3.82e-07222215845450
Pubmed

B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.

RAG1 CD80

2.29e-06422217237403
Pubmed

Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.

CD80 PLCG2

2.29e-06422224080446
Pubmed

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation.

RAG1 PLCG2

3.82e-06522217579183
Pubmed

Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.

RAG1 CD80

3.82e-06522218205792
Pubmed

An obligate cell-intrinsic function for CD28 in Tregs.

RAG1 CD80

3.82e-06522223281398
Pubmed

Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.

RAG1 CD80

3.82e-06522220601598
Pubmed

Paradoxical effect of reduced costimulation in T cell-mediated colitis.

RAG1 CD80

3.82e-06522217442938
Pubmed

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.

RAG1 CD80

3.82e-06522218684012
Pubmed

Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

RAG1 CD80

5.72e-06622215780990
Pubmed

TH17 cell differentiation is regulated by the circadian clock.

CLOCK RAG1

5.72e-06622224202171
Pubmed

Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice.

RAG1 CD80

5.72e-06622224687086
Pubmed

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.

RAG1 CD80

8.01e-06722219188497
Pubmed

The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock.

CLOCK RAG1

8.01e-06722234324837
Pubmed

Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes.

RAG1 CD226

1.07e-05822231810881
Pubmed

Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.

PLCG2 PLCE1

1.37e-0592227589147
Pubmed

Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells.

RAG1 CD80

1.37e-05922227037189
Pubmed

Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.

PLCG2 PLCE1

1.37e-05922210501179
Pubmed

DNAM-1 expression marks an alternative program of NK cell maturation.

RAG1 CD226

1.71e-051022225818301
Pubmed

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.

RAG1 PLCG2

2.09e-051122215728238
Pubmed

Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy.

RAG1 CD226

2.97e-051322226787820
Pubmed

Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.

CD226 SERPINB13

5.16e-051722219690890
Pubmed

Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.

PLCG2 PLCE1

5.81e-05182221979339
Pubmed

Alveolar progenitor and stem cells in lung development, renewal and cancer.

CTSH ABCA3

6.49e-051922224499815
Pubmed

HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.

PLCG2 PLCE1

9.59e-05232229730685
Pubmed

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

RAG1 PLCG2

9.59e-052322222761313
Pubmed

The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.

PLCG2 PLCE1

9.59e-05232229278385
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PLCG2 PLCE1

1.05e-042422210843712
Pubmed

Analysis of a lung defect in autophagy-deficient mouse strains.

CTSH ABCA3

1.23e-042622224275123
Pubmed

Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.

PLCG2 PLCE1

1.33e-042722220336759
Pubmed

Lung epithelial branching program antagonizes alveolar differentiation.

CTSH ABCA3

1.99e-043322224058167
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

PLCG2 PLCE1

2.65e-043822212482669
Pubmed

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.

CD80 PLCG2 BUB1

3.86e-0422722326410627
Pubmed

A secreted protein microarray platform for extracellular protein interaction discovery.

CD226 CD80

4.78e-045122221982860
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCG2 PLCE1

1.77e-0419192832
GeneFamilyPhospholipases

PLCG2 PLCE1

8.79e-0442192467
GeneFamilyAdenosine receptors|V-set domain containing

CD226 CD80

1.25e-02163192590
CoexpressionGSE22886_TH1_VS_TH2_48H_ACT_UP

CTSH CD226 PLCG2 PLCE1

2.08e-05198224M4510
CoexpressionGSE22140_GERMFREE_VS_SPF_ARTHRITIC_MOUSE_CD4_TCELL_DN

CTSH CRYBG1 PLCG2 TRANK1

2.12e-05199224M7645
CoexpressionGSE1460_INTRATHYMIC_T_PROGENITOR_VS_CD4_THYMOCYTE_UP

NUP107 RAG1 PLCG2 BUB1

2.12e-05199224M3439
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_k-means-cluster#2_top-relative-expression-ranked_200

CTSH TRANK1 PLCE1

1.28e-0549203gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_k2_200
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lu, CD11chi CD11b low CD103+ MHCII+ SiglecF-, Lung, avg-3

CTSH CRYBG1 CD226 CD80 PLCE1

3.75e-05424205GSM538231_500
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CTSH CD80 PLCG2 PLCE1

2.31e-061942242b5eee7c3e52b63cce94205d18133c7704329c02
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUP107 COG5 CD226

5.77e-0515422375eac6970259a6916fcfa6d3400509cfa2d98d9d
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CTSH CD80 PLCG2

6.59e-0516122398be0cf8228496b31f7f3e0efd8787e95eb626d1
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CTSH CD80 PLCG2

6.59e-051612237af3b0d4fc7967f6b3e2d255d23fd8b1fd01a7af
ToppCelldroplet-Thymus-nan-3m-Myeloid-B_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80 PLCG2

7.21e-05166223c0af93db981dfd448abc7efcd257f3e5ff066aae
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD226 CD80 BUB1

7.21e-051662238e5a262dc4f04c5fc75b9a7a907832a0d7877df0
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CALHM3 CRYBG1 CD226

7.61e-0516922320b17f1d6d845213479ade09ea0c7ecc277a73c6
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD226 CD80 BUB1

7.74e-051702236b91d4cbe0697b65bfb2e099e7a9b39ea2fba3a9
ToppCelldroplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80 PLCG2

7.74e-0517022329deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCelldroplet-Thymus-nan-21m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80 PLCG2

7.74e-05170223dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCelldroplet-Thymus-nan-21m-Myeloid-B_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80 PLCG2

7.88e-051712238bed33f61f7d12a1ac4fba33f730d839f5ee7bef
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80 PLCG2

8.01e-05172223356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80 PLCG2

8.01e-0517222346fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellfacs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CTSH CD80 PLCG2

8.01e-05172223eaba10a4d4eaab42ad2e2da65ebb20b50edaf815
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80 PLCG2

8.01e-05172223438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCellfacs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CTSH CD226 PLCG2

8.29e-05174223c52aed2ffe9c648e5f23e3459e2d331d6ca214e3
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CALHM3 CRYBG1 ADGRG4

8.58e-0517622371f96cace3f20fbef975037f4deff9b82b0282a1
ToppCellwk_08-11-Hematologic_Lymphocytic-B-Large_pre-B|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RAG1 CRYBG1 PLCG2

8.58e-0517622378417a5ac2e45e97e7b4c56c78c25879a1b58f97
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RAG1 PLCG2 PLCE1

8.58e-0517622305ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CTSH ABCA3 BUB1

8.72e-05177223a68c3688f12aee22f3cb4049c4bccacbacb0fae6
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CTSH CD80 PLCG2

8.72e-0517722337d1abe1a9d8f2b8f4d146bbf1db94104eab6593
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CD80 PLCG2 BUB1

9.63e-05183223dd15e1463a0d57d14800de0df0645c81c56926ae
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_plasma|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

CD80 PLCG2 BUB1

9.63e-051832238ace19c38b89556d2504258a63aa5a2b14f5cd36
ToppCellControl-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

CRYBG1 CD226 CD80

9.79e-05184223c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCellCOPD-Myeloid-cDC1|World / Disease state, Lineage and Cell class

CRYBG1 CD226 CD80

9.79e-0518422342d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Zbtb32+_B_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CTSH CD80 PLCG2

9.94e-051852235fd4a3776259c96cf2dcb87f050af8226acbbda9
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CTSH CD80 PLCG2

9.94e-051852234c55fa96877ab9a00fcbec3fb70fd2208d222527
ToppCellIPF-Myeloid-cDC1|World / Disease state, Lineage and Cell class

CRYBG1 CD226 CD80

1.01e-04186223962c2dada19185628ead77c32fcb07fa95114247
ToppCellControl-Myeloid-cDC1|Control / Disease state, Lineage and Cell class

CRYBG1 CD226 CD80

1.01e-04186223b05c394aa3573ba855abc3066739ca193883b0c3
ToppCellMultiple_Sclerosis-Lymphocyte-B-B_memory|Multiple_Sclerosis / Disease, Lineage and Cell Type

CTSH CD80 PLCG2

1.04e-041882238da631b2c75441b7309f03e7d4c14f15f2367be6
ToppCellIPF-Myeloid-cDC1|Myeloid / Disease state, Lineage and Cell class

CRYBG1 CD226 CD80

1.04e-0418822347bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCellIPF-Myeloid-cDC1|IPF / Disease state, Lineage and Cell class

CRYBG1 CD226 CD80

1.04e-041882232331a2bae1383820d598e93aa86c75b101069bac
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CRYBG1 CD226 CD80

1.04e-04188223d5ce3ffe783c322b4765b790e861727e46bc34b3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CTSH CD80 PLCG2

1.06e-04189223886dceacf96e2b6750c146a381da0bf96a2bb15b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CTSH CD80 PLCG2

1.06e-041892235f1f4321939877374a8ee13de93f2d1390af8e2e
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CTSH CRYBG1 CD80

1.09e-041912237bad04f8afa949ea952c5c0d71eec43271ade680
ToppCellIPF-Myeloid-cDC2|World / Disease state, Lineage and Cell class

CTSH CRYBG1 CD80

1.09e-041912239fda87fb6bc5b8b6c0214ec909ebbc9f3f65319b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CTSH CRYBG1 PLCG2

1.11e-0419222340f44ac4ab673ee6156abdd2074a60b9de3281ad
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CTSH CD80 PLCG2

1.13e-04193223de0213f2105b814f38ffbfd004ea7603230eed68
ToppCellCF-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

CTSH CD80 PLCG2

1.13e-041932237ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCellwk_20-22-Hematologic_Lymphocytic-B-Pro-B|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

RAG1 BUB1 ZNF695

1.14e-041942233590ff471f74a361ee5bf02a58e3104cd3bf7d00
ToppCell10x5'-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_memory|lymph-node_spleen / Manually curated celltypes from each tissue

CTSH CD80 PLCG2

1.14e-04194223b57ae94a092b58623a244a258b4659a3864542c7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CRYBG1 CD226 TRANK1

1.16e-04195223662b50a2aa97373bf343b88caace9717049c722a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CRYBG1 CD226 TRANK1

1.16e-041952239b7157b5e4b81bc35b0e6d9b954279160ea57324
ToppCellmetastatic_Brain-T/NK_cells-Undetermined|T/NK_cells / Location, Cell class and cell subclass

NUP107 ABCA3 PLCG2

1.18e-04196223c17e105e47446a48aa06e1a3810828e20aa56ea9
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CTSH CRYBG1 CD226

1.20e-041972234f7c10a636646dfc82a84026c1b5a36603367abe
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SERPINB13 BUB1 ZNF695

1.20e-041972230a6754a5109bec0d0de42adbfdf4db43ff60c3d2
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2_proliferating-AT2_proliferating_L.0.1.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CTSH ABCA3 BUB1

1.23e-04199223d7dbc551c05da32c698908348572fb0ce1166e10
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate|COVID-19_Mild / Disease, condition lineage and cell class

CD80 PLCG2 PLCE1

1.23e-041992231c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCellMS-Multiple_Sclerosis-Lymphocyte-B-B_memory|Multiple_Sclerosis / Disease, condition lineage and cell class

CTSH CD80 PLCG2

1.23e-04199223ae2979c0d2711580863d3b751f6ff1e3abdfd90e
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CTSH CEBPZOS ABCA3

1.23e-04199223121de4e02585de3a3010398387c523bacf8ce546
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CTSH ABCA3 BUB1

1.23e-041992236a89c3a65fa50af92585c52bec203bcff6f94efc
ToppCellmild-B_intermediate|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CD80 PLCG2 PLCE1

1.25e-042002238e3132a1fe3708f725c5c4077878fb87bbea3678
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat|Hippocampus / BrainAtlas - Mouse McCarroll V32

RAG1 CD226

4.52e-04642223e464bd87c15ba34c174e11fbe8d88e9a8735caf
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Gad1Gad2Chat_Htr3a.Chat_(Interneuron,_Cholinergic_(candidate__CGE-derived_2))|Hippocampus / BrainAtlas - Mouse McCarroll V32

RAG1 CD226

4.52e-0464222bbce496e9682cd74e3163a64d9d20bc6368d3e48
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Gad1Gad2Chat_Htr3a.Chat_(Interneuron,_Cholinergic_(candidate__CGE-derived_2))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

RAG1 CD226

4.52e-046422291371907b75b0b97d2ebd57d4048a81f5e5fd694
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ADGRG4 PLCG2

7.40e-048222272d5a55ca7c03e9c54f865524e206b288f242017
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ADGRG4 PLCG2

7.40e-0482222e500582511814a067852dc3bd78d19937c28ba60
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ADGRG4 PLCG2

7.40e-0482222ea3bdd7b871269eacb81167c6cf59a0e21bf6d83
ToppCellLPS_only-Unknown|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY5 PLCE1

1.45e-031152227a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCellLPS_only-Unknown-Endothelial-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY5 PLCE1

1.45e-03115222c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCellLPS_only-Unknown-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY5 PLCE1

1.45e-03115222ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCellPND07-28-samps-Lymphocyte-T_cells-T_cells_1|PND07-28-samps / Age Group, Lineage, Cell class and subclass

RAG1 CD226

1.52e-03118222461a971f3e8047c727b7c6e00d2d64e97d50c6de
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Metaplastic_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

RAG1 SERPINB13

1.65e-0312322251e49a64fbbf77e2ee21f45fd515d43282b11516
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_B|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ADCY5 SERPINB13

1.65e-03123222e0130010aa406d4e9d8f16ad32858c382277eeb2
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Metaplastic_Carcinoma-4|TCGA-Breast / Sample_Type by Project: Shred V9

RAG1 SERPINB13

1.65e-0312322211802979943a9205f10facda322fc220d4bf7133
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CTSH PLCG2

1.76e-03127222eee8e4a83f7de46807440d202d46eee7dd722001
ToppCellLPS-antiTNF-Unknown|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY5 BUB1

1.81e-03129222739b263296c28554967362060b154f7a95e1341d
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CTSH ABCA3

1.84e-031302226434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD80 BUB1

1.84e-031302220f9d3e6297f48ae14d24ac997d8d3a94f337d4d4
ToppCellLPS-antiTNF-Unknown-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY5 BUB1

1.84e-03130222615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CD80 BUB1

1.84e-03130222fc68a648161dd314d9ee6612fd039cb12171b8c6
ToppCellLPS-antiTNF-Unknown-Endothelial-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY5 BUB1

1.90e-0313222202491930097b75aaeedab9e8200711b0dc610944
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-mDC|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD226 CD80

1.90e-03132222f8e2ba53063007d7507f1837ad669b0e4333cd23
ToppCellEndothelial-H_(cycle)|World / shred on cell class and cell subclass (v4)

SERPINB13 BUB1

1.93e-031332228e3005114761feee028c496cc739e607b35d7831
ToppCell(09)_Ionocytes|World / shred by cell type and Timepoint

ADCY5 PLCG2

1.98e-03135222237b9b646513ca6e4b754c0da95d24015b3661f7
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp4_Mab21l1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RAG1 PLCG2

2.01e-031362229cf076597e6fd9390850fda259daa13022f15893
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CTSH CD80

2.19e-031422228b5441d0564e67ab4db58d9082909b5dab430a28
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

NUP107 CD80

2.28e-03145222b17699f7f98d2361a4d26c26f52db05e7ff69dff
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD226 ABCA3

2.32e-0314622269cbe8d4772f8e46a5e1a1cdca0e370308a97b4f
ToppCellEpithelial-B_(AT1-AT2-progenitors)|World / shred on cell class and cell subclass (v4)

CTSH ABCA3

2.32e-031462224511916904c1fac252cb68e871b782207f8137b3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLCG2 PLCE1

2.32e-03146222ec1f793409d1a81c0f9323eb3c82ffe01dae0e44
ToppCelllung-Type_II_Pneumocytes|lung / shred on tissue and cell subclass

CTSH ABCA3

2.35e-031472228a3039de45b8087f8319e2e37329acf7278219b7
ToppCellLPS_only-Myeloid-Dendritic_cells-mDC|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CD226 CD80

2.35e-0314722226bd9d89e2e7b841cc18030bb7cebb642b987183
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT|GI_small-bowel / Manually curated celltypes from each tissue

CTSH RAG1

2.35e-031472224ba9a86ab7033688a9a2a2dc84c001a49af835b4
ToppCell368C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TRANK1 BUB1

2.44e-03150222c3ad5fa41eb636a5d691c0268c0f1c32cd0de658
ToppCell368C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TRANK1 BUB1

2.44e-0315022278b8029e71d26f336a46274c8afef3435bf536b9
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma|TCGA-Uterus / Sample_Type by Project: Shred V9

CTSH PLCG2

2.47e-031512222810bfa01bd3016aeba29735eb4a9284792e8aac
ToppCellE18.5-samps-Mesenchymal-Pericyte-pericyte_C|E18.5-samps / Age Group, Lineage, Cell class and subclass

ADCY5 PLCE1

2.47e-031512223f2abaa42876ce7a71d934ff16abe0cab0991a05
ToppCellDendritic_Cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

CRYBG1 CD80

2.47e-03151222e089bf197ed60e7243160521d4390d4b40a3832b
ToppCelldroplet-Fat-Scat-21m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD226

2.47e-0315122279827a76c675dcb82f59c0a45d0f962b02d5bfd6
ToppCellfacs-MAT-Fat-24m-Lymphocytic-NK_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD226 TRANK1

2.51e-03152222fa03262e2853b7d35ef8cdbb652930abad90563c
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAG1 CD226

2.57e-03154222f78b01c19afcbab6319f61e4d6023ecb3d510d24
ToppCellfacs-Lung-Endomucin-3m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH PLCG2

2.57e-031542228746663a822d93a8510081c81a8c971b51653067
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH PLCG2

2.57e-0315422227f76e4b3c055aa382708f1610c685f02d6d6114
ToppCellIonocyte|World / shred by cell class for nasal brushing

ADCY5 PLCG2

2.57e-031542226b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80

2.60e-03155222d2e489a08b4e711bd2ed483dcc4da7dbbaa4feea
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80

2.60e-03155222cb456d6f13bfb5cb400c0840a0ab6ba4616dcf37
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTSH CD80

2.60e-03155222a547fdcd974b0813ce6c8cccfec9fff74cac2d1a
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CD80 PLCG2

2.60e-031552229f937ae48767fdcf1a944af4de0530d9c0ab441d
DrugLypressin

ADCY5 PLCG2 PLCE1

1.24e-0547223CID000005772
Drug8-iso Misoprostol

ADCY5 PLCG2 PLCE1

2.85e-0562223CID004183806
Drug(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Up 200; 11uM; MCF7; HT_HG-U133A

CD80 TRANK1 SERPINB13 BUB1

3.59e-051982243384_UP
Drugsulprostone

ADCY5 PLCG2 PLCE1

4.29e-0571223CID005312153
DiseaseHamman-Rich syndrome

ABCA3 DPP9

4.37e-0514212C0085786
DiseaseIdiopathic Pulmonary Fibrosis

ABCA3 DPP9

1.00e-0421212C1800706
Diseasechronic widespread pain

CD226 PLCG2

1.21e-0423212EFO_0010099
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

NUP107 PLCE1

2.07e-0430212C1868672
Diseasepersonality trait

CLOCK PLCE1

3.52e-0439212EFO_0004365
DiseaseColorectal Neoplasms

CD226 ABCA3 BUB1

9.60e-04277213C0009404
Diseasehypothyroidism

CD226 CD80 TRANK1

1.03e-03284213EFO_0004705
DiseaseColorectal Carcinoma

CTSH CD226 ABCA3 BUB1

1.38e-03702214C0009402
Diseaseplatelet component distribution width

CD226 ADCY5 PLCG2 TRANK1

1.80e-03755214EFO_0007984

Protein segments in the cluster

PeptideGeneStartEntry
FSKMHTSQDFRQTMS

CEBPZOS

31

A8MTT3
QHMFMKFYSAHLFQN

BUB1

846

O43683
RSSYNEMTEMFNFNH

ADGRG4

921

Q8IZF6
MDKFRMLFQHFQSSS

CALHM3

1

Q86XJ0
MLFQHFQSSSESVMN

CALHM3

6

Q86XJ0
SFMVSTFFSKANMAA

ABCA3

361

Q99758
QMKYINEHSFNNFQM

ADCY5

1161

O95622
SSKLDFNMTTNHSFM

CD80

201

P33681
MNAHNALKTSGFTMN

RAG1

1006

P15918
SMSMFSDFLQSFLKH

NUP107

151

P57740
HEMMQQTFNLFSTKN

IFNA14

81

P01570
SHFFNLMFTTNMLES

KLHL7

66

Q8IXQ5
ALNFQTADKYMQMNH

PLCG2

1011

P16885
LSSQFHMATNSSMFL

COG5

391

Q9UP83
HMATNSSMFLKQAFE

COG5

396

Q9UP83
FSHSCSMSQNFDMFV

DPP9

546

Q86TI2
GNHTFKMALNQFSDM

CTSH

71

P09668
FSNAHMIMYSEKNFG

CRYBG1

1316

Q9Y4K1
FLNSTMASNNMTLFF

CD226

81

Q15762
KGFQSFMVSDSNMSF

PLCE1

1201

Q9P212
MSQFQFSAQLGAMQH

CLOCK

511

O15516
DSFNMQFLFHSLAMS

ZNF695

46

Q8IW36
VQMMTQSHSFSFTFL

SERPINB13

211

Q9UIV8
NIMKFHSFSTNMAFN

TRANK1

981

O15050