Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ZnF_C2HC	CPSF4 RP9 RBM4B RBM4	3.29e-06	55	35	4	SM00343
Domain	Znf_CCHC	CPSF4 RP9 RBM4B RBM4	3.29e-06	55	35	4	IPR001878
Domain	zf-CCHC	CPSF4 RBM4B RBM4	1.04e-05	23	35	3	PF00098
Domain	-	CPSF4 RBM4B RBM4	1.52e-05	26	35	3	4.10.60.10
Domain	ZF_CCHC	CPSF4 RBM4B RBM4	3.79e-05	35	35	3	PS50158
Domain	ZnF_GATA	GATA2 GATA6	2.23e-04	12	35	2	SM00401
Domain	Znf_GATA	GATA2 GATA6	3.53e-04	15	35	2	IPR000679
Domain	GATA	GATA2 GATA6	3.53e-04	15	35	2	PF00320
Domain	GATA_ZN_FINGER_1	GATA2 GATA6	4.03e-04	16	35	2	PS00344
Domain	GATA_ZN_FINGER_2	GATA2 GATA6	4.03e-04	16	35	2	PS50114
Domain	-	CPSF4 ZC3H4	2.54e-03	40	35	2	4.10.1000.10
Domain	ZnF_C3H1	CPSF4 ZC3H4	3.65e-03	48	35	2	SM00356
Domain	zf-CCCH	CPSF4 ZC3H4	3.80e-03	49	35	2	PF00642
Domain	Glycoside_hydrolase_SF	FUCA2 NAGLU	4.43e-03	53	35	2	IPR017853
Domain	-	GATA2 GATA6	5.10e-03	57	35	2	3.30.50.10
Domain	Znf_CCCH	CPSF4 ZC3H4	5.28e-03	58	35	2	IPR000571
Domain	Znf_NHR/GATA	GATA2 GATA6	5.28e-03	58	35	2	IPR013088
Domain	ZF_C3H1	CPSF4 ZC3H4	5.28e-03	58	35	2	PS50103
Pubmed	Phylogenetic and molecular characterization of the splicing factor RBM4.	RBM4B RBM4	1.04e-06	2	36	2	23527094
Pubmed	Dysregulated expression of GATA2 and GATA6 transcription factors in adenomyosis: implications for impaired endometrial receptivity.	GATA2 GATA6	1.04e-06	2	36	2	37972693
Pubmed	The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.	RBM4B RBM4	1.04e-06	2	36	2	18708123
Pubmed	Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer.	GATA2 GATA6	1.04e-06	2	36	2	29106391
Pubmed	Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.	GATA2 GATA6	1.04e-06	2	36	2	24603652
Pubmed	Are Urinary Tubular Injury Markers Useful in Chronic Kidney Disease? A Systematic Review and Meta Analysis.	HAVCR1 NAGLU	3.12e-06	3	36	2	27907168
Pubmed	Rare genetic variants in GATA transcription factors in patients with hypertrophic cardiomyopathy.	GATA2 GATA6	3.12e-06	3	36	2	28381408
Pubmed	RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.	RBM4B RBM4	3.12e-06	3	36	2	27821480
Pubmed	A novel splicing regulator shares a nuclear import pathway with SR proteins.	RBM4B RBM4	3.12e-06	3	36	2	12628928
Pubmed	Histone modifications silence the GATA transcription factor genes in ovarian cancer.	GATA2 GATA6	6.24e-06	4	36	2	16607277
Pubmed	The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.	GATA2 GATA6	1.04e-05	5	36	2	20206639
Pubmed	Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling.	GATA2 GATA6	1.04e-05	5	36	2	15016828
Pubmed	RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression.	RBM4B RBM4	1.56e-05	6	36	2	27009199
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	GATA2 GATA6 CPSF4 ZDHHC13 GLIS2 ZNF697 KLHL26	1.65e-05	808	36	7	20412781
Pubmed	LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1.	RBM4B RBM4	2.18e-05	7	36	2	17264215
Pubmed	Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.	GATA2 GATA6	2.18e-05	7	36	2	11724781
Pubmed	GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells.	GATA2 GATA6	2.18e-05	7	36	2	18212046
Pubmed	Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules.	GATA2 GATA6	2.91e-05	8	36	2	29197504
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	CPSF4 CABIN1 ZC3H4 RBM4 GLIS2	3.48e-05	363	36	5	14691545
Pubmed	Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency.	RBM4B RBM4	3.73e-05	9	36	2	37670183
Pubmed	RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.	RBM4B RBM4	6.83e-05	12	36	2	29581187
Pubmed	Gata6 is an important regulator of mouse pancreas development.	GATA2 GATA6	1.24e-04	16	36	2	16887115
Pubmed	RBM4 promotes pancreas cell differentiation and insulin expression.	RBM4B RBM4	1.40e-04	17	36	2	23129807
Pubmed	Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets.	GATA2 GATA6	1.58e-04	18	36	2	15929941
Pubmed	Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.	TENM3 NAGLU	1.76e-04	19	36	2	14671302
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SEMA6C FBN3 VCPIP1	1.88e-04	107	36	3	11347906
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CPSF4 FUCA2 FGFR4 TENM3 ZDHHC13 RBM4 NAGLU	2.00e-04	1201	36	7	35696571
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	GATA2 GATA6 CPSF4 BCOR CABIN1 RBM4 VCPIP1	3.14e-04	1294	36	7	30804502
Pubmed	GATA6 is a crucial regulator of Shh in the limb bud.	GATA2 GATA6	3.33e-04	26	36	2	24415953
Pubmed	Novel genes differentially expressed in cortical regions during late neurogenesis.	WSCD1 TENM3	3.87e-04	28	36	2	17614941
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	BCOR RBM4B RBM4	5.26e-04	152	36	3	38360978
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	GATA2 GATA6 HAVCR1 FGFR4	9.42e-04	424	36	4	21731673
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	GATA2 GATA6	1.61e-04	15	23	2	82
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	RBM4B RBM4	4.56e-04	25	23	2	74
Drug	diatrizoate	CABIN1 PKDREJ NAGLU	4.73e-06	21	36	3	CID000002140
Drug	Cyanocobalamin [68-19-9]; Up 200; 3uM; MCF7; HT_HG-U133A	ZNF747 CPSF4 PAQR6 FGFR4 LTB4R	1.36e-05	196	36	5	3252_UP
Drug	Sulfaguanidine [57-67-0]; Down 200; 18.6uM; MCF7; HT_HG-U133A	FGFR4 CABIN1 ZDHHC13 NAGLU KLHL26	1.40e-05	197	36	5	1495_DN
Drug	Allantoin [97-59-6]; Down 200; 25.2uM; MCF7; HT_HG-U133A	GATA2 PAQR6 BCOR CABIN1 KLHL26	1.50e-05	200	36	5	5471_DN
Disease	serum gamma-glutamyl transferase measurement	ZNF747 WSCD1 CABIN1 PTH1R JPH3 NAGLU	7.64e-04	914	36	6	EFO_0004532
Disease	stomach cancer (is_implicated_in)	FGFR4 BCOR	3.51e-03	72	36	2	DOID:10534 (is_implicated_in)
Disease	non-small cell lung carcinoma	WSCD1 FUCA2	3.80e-03	75	36	2	EFO_0003060
Disease	sphingomyelin measurement	WSCD1 HAVCR1 FBN3	4.69e-03	278	36	3	EFO_0010118

Protein segments in the cluster

Peptide	Gene	Start	Entry
CCGRAERGGHWYKEG	FGFR4	56	P22455
GSRFHAYCCPGWRTF	FBN3	61	Q75N90
AGYCALHEACARGWL	BCOR	1496	Q6W2J9
LHAWRAGCAGSVCYR	ANTKMT	116	Q9BQD7
RYLRDFCGCHVAWSG	NAGLU	91	P54802
GCYRCGKEGHWSKEC	RBM4	161	Q9BWF3
GKVDWGYCDCRHGSV	PRSS12	156	P56730
FAEWCLDYGAHGCRI	LANCL2	396	Q9NS86
GYCCHWEGCARHGRG	GLIS2	201	Q9BZE0
WEGCARHGRGFNARY	GLIS2	206	Q9BZE0
FYRLGLCWGRGHGCG	PAQR6	201	Q6TCH4
GCYRCGKEGHWSKEC	RBM4B	161	Q9BQ04
GTWSFGLAGCRLCHY	LTB4R	81	Q15722
DRWGAGSICKHGGFY	FUCA2	261	Q9BTY2
WRRDGTGHYLCNACG	GATA2	306	P23769
WRRDGTGHYLCNACG	GATA6	401	Q92908
GYACSLKRRTWGHAG	KLHL26	441	Q53HC5
HEYLGRRSWCCNSDG	CABIN1	896	Q9Y6J0
GRFGCCSAAHYSAKW	DAGLB	606	Q8NCG7
RCGDGCHGGFVWDAF	CTSW	186	P56202
YACHECGKRFRGWSG	GLI4	211	P10075
WYDRGFCKHGPLCRH	CPSF4	126	O95639
IRFGYKFWCGATCLG	PGBD3	291	Q8N328
WRCKRYGHRTGDKEC	RP9	106	Q8TA86
SLCFPHGGTGRRWYC	PKDREJ	76	Q9NTG1
GVYCCRVEHRGWFND	HAVCR1	101	Q96D42
CKWHRGGSNGRSYKR	UCK1	236	Q9HA47
RYDQHCLWTGRCIGF	ZDHHC13	451	Q8IUH4
KGHAYRRCDRNGSWE	PTH1R	141	Q03431
HGCYVCGKSFAWRST	ZNF747	181	Q9BV97
YCGWHSSRGCVDIRG	SEMA6C	536	Q9H3T2
NGQYSKGRCLCFSGW	TENM3	556	Q9P273
RSTGGKCGCGFKHFW	VCPIP1	566	Q96JH7
CKYFVEGRCTWGDHC	ZC3H4	396	Q9UPT8
HGCGECGKRFSWRSD	ZNF697	381	Q5TEC3
RKCAGHLGYAADRNW	WSCD1	441	Q658N2
EWTHGFKGRYGVREC	JPH3	86	Q8WXH2