Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	fructose-bisphosphate aldolase activity	ALDOA ALDOC	7.42e-05	3	100	2	GO:0004332
GeneOntologyBiologicalProcess	vesicle cargo loading	CTAGE9 CTAGE6 CTAGE8 CTAGE15 CTAGE4 SEC23A	2.05e-08	36	101	6	GO:0035459
GeneOntologyBiologicalProcess	endoplasmic reticulum to Golgi vesicle-mediated transport	CTAGE9 COPB1 CTAGE6 RANGRF CTAGE8 CTAGE15 ERP29 CTAGE4 SEC23A	8.73e-08	159	101	9	GO:0006888
GeneOntologyBiologicalProcess	SCF complex assembly	CAND1 CAND2	2.37e-05	2	101	2	GO:0010265
GeneOntologyBiologicalProcess	Golgi vesicle transport	CTAGE9 COPB1 CTAGE6 RANGRF CTAGE8 CTAGE15 ERP29 CTAGE4 SEC23A	4.36e-05	339	101	9	GO:0048193
GeneOntologyCellularComponent	endoplasmic reticulum exit site	CTAGE9 CTAGE6 CTAGE8 CTAGE15 CTAGE4 SEC23A	5.29e-08	42	102	6	GO:0070971
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	CTAGE9 CYP1B1 ARHGAP32 COPB1 WDR81 CTAGE6 XPO1 NCLN TMX1 ERG28 MTOR NUP210 CTAGE8 CTAGE15 CTAGE4 SEC23A NOTCH3	2.24e-04	1327	102	17	GO:0042175
GeneOntologyCellularComponent	ficolin-1-rich granule	CAND1 IMPDH1 COPB1 HUWE1 ALDOA ALDOC	2.95e-04	185	102	6	GO:0101002
GeneOntologyCellularComponent	ficolin-1-rich granule lumen	CAND1 IMPDH1 HUWE1 ALDOA ALDOC	3.56e-04	124	102	5	GO:1904813
GeneOntologyCellularComponent	endoplasmic reticulum membrane	CTAGE9 CYP1B1 ARHGAP32 COPB1 WDR81 CTAGE6 NCLN TMX1 ERG28 MTOR NUP210 CTAGE8 CTAGE15 CTAGE4 SEC23A NOTCH3	5.12e-04	1293	102	16	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	CTAGE9 CYP1B1 ARHGAP32 COPB1 WDR81 CTAGE6 NCLN TMX1 ERG28 MTOR NUP210 CTAGE8 CTAGE15 CTAGE4 SEC23A NOTCH3	5.38e-04	1299	102	16	GO:0098827
Domain	ARM-like	CAND1 CAND2 COPB1 HGH1 PUM2 XPO1 HUWE1 TELO2 MTOR ANKAR PPP6R2	1.93e-07	270	99	11	IPR011989
Domain	ARM-type_fold	CAND1 CAND2 COPB1 HGH1 PUM2 XPO1 HUWE1 PPP2R5D TELO2 MTOR ANKAR PPP6R2	2.37e-07	339	99	12	IPR016024
Domain	-	CAND1 CAND2 COPB1 HGH1 PUM2 XPO1 TELO2 MTOR ANKAR	2.76e-06	222	99	9	1.25.10.10
Domain	TATA-bd_TIP120	CAND1 CAND2	2.78e-05	2	99	2	IPR013932
Domain	TIP120	CAND1 CAND2	2.78e-05	2	99	2	PF08623
Domain	FBA_I	ALDOA ALDOC	8.32e-05	3	99	2	IPR000741
Domain	Glycolytic	ALDOA ALDOC	8.32e-05	3	99	2	PF00274
Domain	Aldolase_I_AS	ALDOA ALDOC	8.32e-05	3	99	2	IPR029768
Domain	ALDOLASE_CLASS_I	ALDOA ALDOC	8.32e-05	3	99	2	PS00158
Domain	HEAT	CAND1 CAND2 XPO1 MTOR	2.53e-04	58	99	4	IPR000357
Domain	P-type_ATPase_IIC	ATP1A4 ATP4A	4.11e-04	6	99	2	IPR005775
Domain	HEAT_REPEAT	CAND1 CAND2 XPO1 MTOR	5.21e-04	70	99	4	PS50077
Domain	DHC_N1	DNAH5 DNAH9	7.63e-04	8	99	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH5 DNAH9	7.63e-04	8	99	2	IPR013594
Domain	-	IMPDH1 ALDOA ALDOC	1.43e-03	42	99	3	3.20.20.70
Domain	Aldolase_TIM	IMPDH1 ALDOA ALDOC	1.63e-03	44	99	3	IPR013785
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH9	2.43e-03	14	99	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH9	2.43e-03	14	99	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH9	2.43e-03	14	99	2	IPR013602
Domain	DHC_N2	DNAH5 DNAH9	2.43e-03	14	99	2	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH5 DNAH9	2.43e-03	14	99	2	IPR011704
Domain	MT	DNAH5 DNAH9	2.43e-03	14	99	2	PF12777
Domain	AAA_8	DNAH5 DNAH9	2.43e-03	14	99	2	PF12780
Domain	AAA_5	DNAH5 DNAH9	2.43e-03	14	99	2	PF07728
Domain	DHC_fam	DNAH5 DNAH9	2.79e-03	15	99	2	IPR026983
Domain	Dynein_heavy	DNAH5 DNAH9	2.79e-03	15	99	2	PF03028
Domain	Dynein_heavy_dom	DNAH5 DNAH9	2.79e-03	15	99	2	IPR004273
Domain	ATPase_P-typ_TM_dom	ATP1A4 ATP4A	3.18e-03	16	99	2	IPR023298
Domain	-	ATP1A4 ATP4A	3.18e-03	16	99	2	1.20.1110.10
Domain	ATPase_P-typ_cation-transptr_C	ATP1A4 ATP4A	3.59e-03	17	99	2	IPR006068
Domain	Cation_ATPase_C	ATP1A4 ATP4A	3.59e-03	17	99	2	PF00689
Domain	Cation_ATPase_N	ATP1A4 ATP4A	4.03e-03	18	99	2	PF00690
Domain	Cation_ATPase_N	ATP1A4 ATP4A	4.03e-03	18	99	2	SM00831
Domain	-	AGR2 AGR3 TMX1 ERP29	4.05e-03	122	99	4	3.40.30.10
Domain	ATPase_P-typ_cation-transptr_N	ATP1A4 ATP4A	4.48e-03	19	99	2	IPR004014
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	CAND1 COPB1 AGR2 WDR81 HUWE1 PGLS ERP29 ALDOA ALDOC NNT IQGAP3 ATP5F1A VAV2 SEC23A MVD	2.45e-08	807	106	15	30575818
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DIP2B ARHGAP32 AMPD2 CAND1 HDAC4 HECTD4 WDR81 HUWE1 UBN2 PPP2R5D AGO1 SHANK2 MTOR HERC2 PPP6R2 SEC23A	3.79e-08	963	106	16	28671696
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	AMPD2 CAND1 CAND2 COPB1 HGH1 XPO1 HUWE1 NCLN TMX1 PPP2R5D TELO2 MTOR NUP210 IQGAP3 SEC23A	1.81e-07	942	106	15	31073040
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CAND1 COPB1 XPO1 HUWE1 NCLN GSR TMX1 MTOR NUP210 NOL7 ERP29 ALDOA ALDOC DNAH5 NNT IQGAP3 ATP5F1A SEC23A	3.00e-07	1425	106	18	30948266
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	DIP2B CAND1 COPB1 XPO1 HUWE1 ALDOA ALDOC NNT SEC23A	1.15e-06	344	106	9	30333137
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	CAND1 CAND2 XPO1 ATP5F1A	1.16e-06	26	106	4	23181366
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	COPB1 KMT5A XPO1 HUWE1 HERC2 ALDOC ATP5F1A	1.51e-06	182	106	7	31067453
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	DIP2B CAND1 CAND2 PTPN23 XPO1 HUWE1 NCLN GSR TMX1 TELO2 MTOR NUP210 PGLS PPP6R2	1.61e-06	974	106	14	28675297
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	CAND2 COPB1 PTPN23 HUWE1 MAP3K4 TMX1 IGF2BP3 MTOR PGLS DNAH5 IQGAP3 ATP5F1A	1.67e-06	704	106	12	29955894
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	AMPD2 CAND1 IMPDH1 COPB1 HGH1 PTPN23 XPO1 HUWE1 GSR IGF2BP3 PPP2R5D TELO2 MTOR ALDOA ALDOC SEC23A MVD	1.93e-06	1455	106	17	22863883
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	CAND1 CAND2 COPB1 HUWE1 NCLN FAM83H TELO2 MTOR NUP210 HERC2 IQGAP3	2.56e-06	606	106	11	36538041
Pubmed	The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.	XPO1 HUWE1 MFF MTOR HERC2	2.65e-06	71	106	5	29346117
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CAND1 COPB1 XPO1 HUWE1 NCLN FAM83H IGF2BP3 SACS NUP210 NOL7 HERC2 NNT ATP5F1A SEC23A	2.88e-06	1024	106	14	24711643
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	HUWE1 AGO1 SACS HERC2 SEC23A	3.72e-06	76	106	5	27542412
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CAND1 COPB1 PTPN23 XPO1 HUWE1 FAM83H TELO2 MTOR NUP210 ALDOA SEC23A	4.18e-06	638	106	11	33239621
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	COPB1 XPO1 HUWE1 TUBB1 IGF2BP3 MTOR NUP210 ALDOA IQGAP3 ATP5F1A SEC23A	4.77e-06	647	106	11	26618866
Pubmed	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.	CAND1 CAND2 TELO2 ALDOA ALDOC ATP5F1A	8.40e-06	155	106	6	22673621
Pubmed	The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma.	IGF2BP3 NOTCH3	9.20e-06	2	106	2	37853162
Pubmed	Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A.	ALDOA ALDOC	9.20e-06	2	106	2	3009179
Pubmed	mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.	MTOR PHLPP1	9.20e-06	2	106	2	21177869
Pubmed	A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling.	MTOR QDPR	9.20e-06	2	106	2	28633336
Pubmed	Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family.	AGR2 AGR3	9.20e-06	2	106	2	15935701
Pubmed	The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.	AGR2 AGR3	9.20e-06	2	106	2	25751668
Pubmed	Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.	RAPGEF3 MTOR	9.20e-06	2	106	2	22173835
Pubmed	The role of AGR2 and AGR3 in cancer: similar but not identical.	AGR2 AGR3	9.20e-06	2	106	2	25666661
Pubmed	Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone.	XPO1 MTOR	9.20e-06	2	106	2	27693556
Pubmed	AGR3 in breast cancer: prognostic impact and suitable serum-based biomarker for early cancer detection.	AGR2 AGR3	9.20e-06	2	106	2	25875093
Pubmed	Regulation of AGR2 expression via 3'UTR shortening.	AGR2 MTOR	9.20e-06	2	106	2	28408318
Pubmed	Predictive models for breast cancer susceptibility from multiple single nucleotide polymorphisms.	CYP1B1 CYP11B2	9.20e-06	2	106	2	15102677
Pubmed	Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.	AGR2 AGR3	9.20e-06	2	106	2	35857928
Pubmed	Defining the membrane proteome of NK cells.	DIP2B CAND1 COPB1 NVL XPO1 HUWE1 NCLN MTOR NUP210 ERP29 HERC2 ALDOA NNT ATP5F1A	1.28e-05	1168	106	14	19946888
Pubmed	The human protein disulfide isomerase gene family.	AGR3 TMX1 ERP29	1.50e-05	16	106	3	23245351
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	AMPD2 CAND1 COPB1 PTPN23 XPO1 HUWE1 TMX1 ERG28 MTOR ALDOA NNT ATP5F1A VAV2 SEC23A MVD	1.73e-05	1367	106	15	32687490
Pubmed	Mode of interactions of human aldolase isozymes with cytoskeletons.	ALDOA ALDOC	2.76e-05	3	106	2	9244396
Pubmed	Aldolase positively regulates of the canonical Wnt signaling pathway.	ALDOA ALDOC	2.76e-05	3	106	2	24993527
Pubmed	TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues.	CAND1 CAND2	2.76e-05	3	106	2	10441524
Pubmed	PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice.	KMT5A PGR	2.76e-05	3	106	2	28731465
Pubmed	TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3.	CAND1 CAND2	2.76e-05	3	106	2	12207886
Pubmed	Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.	RAPGEF3 MTOR	2.76e-05	3	106	2	19725049
Pubmed	Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice.	PGR MTOR	2.76e-05	3	106	2	22025690
Pubmed	TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2.	TELO2 MTOR	2.76e-05	3	106	2	33416177
Pubmed	A conserved PUF-Ago-eEF1A complex attenuates translation elongation.	PUM2 AGO1	2.76e-05	3	106	2	22231398
Pubmed	IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor.	PGR IGF2BP3	2.76e-05	3	106	2	29217458
Pubmed	Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia.	DNAH5 DNAH9	2.76e-05	3	106	2	15750039
Pubmed	Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.	DNAH5 DNAH9	2.76e-05	3	106	2	15845866
Pubmed	A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth.	PPP2R5D MTOR	2.76e-05	3	106	2	33482199
Pubmed	Human skeletal-muscle aldolase: N-terminal sequence analysis of CNBr- and o-iodosobenzoic acid-cleavage fragments.	ALDOA ALDOC	2.76e-05	3	106	2	6696436
Pubmed	Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.	CYP1B1 PGR	2.76e-05	3	106	2	18628428
Pubmed	Phospholipase D2 directly interacts with aldolase via Its PH domain.	ALDOA ALDOC	2.76e-05	3	106	2	11876650
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	CAND1 CAND2 COPB1 XPO1 HUWE1 NCLN IGF2BP3 MIDN TELO2 NUP210 ALDOA IQGAP3 ATP5F1A SEC23A	2.88e-05	1257	106	14	37317656
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	HDAC4 PTPN23 PPP2R5D MTOR	3.05e-05	58	106	4	31067491
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CYP1B1 CAND1 CAND2 COPB1 XPO1 HUWE1 NCLN UBN2 IGF2BP3 TELO2 MTOR NUP210 ERP29 ALDOA ATP5F1A	3.16e-05	1440	106	15	30833792
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	COPB1 NVL XPO1 HUWE1 IGF2BP3 MTOR NUP210 HERC2 NNT SEC23A	3.21e-05	653	106	10	22586326
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2B IMPDH1 HECTD4 THAP8 HUWE1 NCLN FAM83H CYREN SHANK2 MTOR WDR90 HERC2 IQGAP3	3.24e-05	1105	106	13	35748872
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	CAND1 XPO1 HUWE1 NCLN TMX1 TELO2 MTOR NUP210 HERC2 ATP5F1A	3.38e-05	657	106	10	36180527
Pubmed	A catalogue of putative HIV-1 protease host cell substrates.	AMPD2 HUWE1 GSR ALDOA ATP5F1A	4.04e-05	124	106	5	22944692
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CAND1 HGH1 AGR2 PTPN23 XPO1 NCLN MFF GSR TMX1 IGF2BP3 PPP2R5D NUP210 ERP29 ATP5F1A	4.04e-05	1297	106	14	33545068
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	ULBP3 FAM83H MINDY3 PPP2R5D TELO2 IQGAP3 ATP5F1A	4.06e-05	302	106	7	30561431
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	COPB1 XPO1 HUWE1 NUP210 ALDOA NNT ATP5F1A SEC23A	4.70e-05	422	106	8	27342126
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	CAND1 CAND2 COPB1 XPO1 HUWE1 GSR IGF2BP3 ERP29 ALDOA ALDOC IQGAP3 ATP5F1A SEC23A	4.84e-05	1149	106	13	35446349
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CYP1B1 CAND1 KMT2B IMPDH1 PUM2 ZNF385A UBN2 MFF SHANK2 ATXN7 NOL7 DECR2 HERC2 IQGAP3 ATP5F1A	4.91e-05	1497	106	15	31527615
Pubmed	hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.	AGR2 AGR3	5.50e-05	4	106	2	12592373
Pubmed	ER+ /PR+ /TFF3+ /IMP3- immunoprofile distinguishes endometrioid from serous and clear cell carcinomas of the endometrium: a study of 401 cases.	PGR IGF2BP3	5.50e-05	4	106	2	23570281
Pubmed	Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.	CTAGE9 CTAGE8	5.50e-05	4	106	2	27311593
Pubmed	Lin28a protects against cardiac ischaemia/reperfusion injury in diabetic mice through the insulin-PI3K-mTOR pathway.	LIN28A MTOR	5.50e-05	4	106	2	25688987
Pubmed	Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance.	CTAGE9 CTAGE8	5.50e-05	4	106	2	33718348
Pubmed	Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes.	CTAGE9 CTAGE8	5.50e-05	4	106	2	12586826
Pubmed	DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.	DNAH5 DNAH9	5.50e-05	4	106	2	18950741
Pubmed	MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.	CTAGE9 CTAGE8	5.50e-05	4	106	2	31244610
Pubmed	Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites.	CTAGE9 CTAGE8	5.50e-05	4	106	2	21807889
Pubmed	Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression.	HDAC4 MTOR	5.50e-05	4	106	2	30145794
Pubmed	p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.	PGR MTOR	5.50e-05	4	106	2	27454290
Pubmed	Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump.	ALDOA ALDOC	5.50e-05	4	106	2	11399750
Pubmed	Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.	QDPR ALDOC ATP5F1A	6.03e-05	25	106	3	19405953
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	HUWE1 MTOR SEC23A	6.03e-05	25	106	3	30340022
Pubmed	Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.	CAND1 HUWE1 TMX1 TELO2 MTOR SEC23A	6.66e-05	224	106	6	32941674
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	CAND1 COPB1 XPO1 HUWE1	7.15e-05	72	106	4	36376293
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CAND1 COPB1 XPO1 ZNF557 IGF2BP3 NNT ATP5F1A SEC23A	7.48e-05	451	106	8	36168627
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	CAND2 TELO2 MTOR	7.63e-05	27	106	3	23027611
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	DIP2B COPB1 XPO1 ALDOA QDPR ALDOC	9.08e-05	237	106	6	29564676
Pubmed	Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.	CTAGE9 CTAGE8	9.15e-05	5	106	2	19131326
Pubmed	Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations.	ALDOA ALDOC	9.15e-05	5	106	2	3674018
Pubmed	cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.	CTAGE9 CTAGE4	9.15e-05	5	106	2	12839582
Pubmed	DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.	DNAH5 DNAH9	9.15e-05	5	106	2	26909801
Pubmed	A phosphatase cascade by which rewarding stimuli control nucleosomal response.	XPO1 PPP2R5D	9.15e-05	5	106	2	18496528
Pubmed	ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.	DNAH5 DNAH9	9.15e-05	5	106	2	23849778
Pubmed	Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.	CTAGE9 CTAGE8	9.15e-05	5	106	2	18630941
Pubmed	Characterization and expression pattern of the novel MIA homolog TANGO.	CTAGE9 CTAGE8	9.15e-05	5	106	2	15183315
Pubmed	Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development.	CTAGE9 CTAGE8	9.15e-05	5	106	2	38439956
Pubmed	The establishment of rotational polarity in the airway and ependymal cilia: analysis with a novel cilium motility mutant mouse.	DNAH5 DNAH9	9.15e-05	5	106	2	23525783
Pubmed	A tissue-specific atlas of mouse protein phosphorylation and expression.	CTAGE9 CTAGE8	9.15e-05	5	106	2	21183079
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	AMPD2 CAND1 PTPN23 XPO1 HUWE1 NCLN GSR IGF2BP3 PPP2R5D PGLS DECR2 ALDOA ATP5F1A SEC23A	1.02e-04	1415	106	14	28515276
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	CAND1 COPB1 XPO1 HUWE1 IGF2BP3 ERP29 ALDOA NNT SEC23A	1.04e-04	607	106	9	39147351
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ARHGAP32 KMT2B COPB1 AGR2 SACS ATXN7 ERP29 ZNF488 PPP6R2	1.05e-04	608	106	9	16713569
Pubmed	TRIM24 is an insulin-responsive regulator of P-bodies.	PUM2 XPO1 IGF2BP3 AGO1	1.08e-04	80	106	4	35803934
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	CAND1 CAND2 HUWE1 ALDOC SEC23A	1.09e-04	153	106	5	26365490
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	CAND1 XPO1 IGF2BP3 ALDOA	1.19e-04	82	106	4	30274258
Pubmed	Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.	CAND1 CAND2 COPB1 HUWE1 GSR ALDOC	1.19e-04	249	106	6	30097533
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	CAND1 COPB1 XPO1 TMX1 IGF2BP3 ALDOA ATP5F1A SEC23A	1.22e-04	484	106	8	31995728
Pubmed	Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome.	COPB1 XPO1 HUWE1 TMX1	1.30e-04	84	106	4	31616248
Interaction	CTAGE1 interactions	CTAGE6 CTAGE8 CTAGE15 CTAGE4	1.43e-07	10	105	4	int:CTAGE1
Interaction	AGR2 interactions	CAND1 HDAC4 COPB1 AGR2 WDR81 HUWE1 PGLS ERP29 ALDOA ALDOC NNT IQGAP3 ATP4A ATP5F1A VAV2 SEC23A MVD	6.37e-06	934	105	17	int:AGR2
Interaction	CSNK1A1 interactions	CAND1 HDAC4 KMT5A AGR2 XPO1 FAM83H PPP2R5D PHLPP1 ATP5F1A SEC23A	3.03e-05	381	105	10	int:CSNK1A1
Interaction	SLC15A3 interactions	CAND1 CAND2 COPB1 XPO1 HUWE1 NUP210 ALDOA ATP5F1A	3.10e-05	234	105	8	int:SLC15A3
Interaction	ZFP36 interactions	ARHGAP32 PUM2 XPO1 LIN28A MAP3K4 AGO1 SMAP2	4.55e-05	181	105	7	int:ZFP36
Interaction	WDR81 interactions	AGR2 WDR81 XPO1 HUWE1	4.97e-05	39	105	4	int:WDR81
Interaction	BORCS8-MEF2B interactions	HDAC4 AGR2 UBN2	5.97e-05	15	105	3	int:BORCS8-MEF2B
Interaction	ATOH1 interactions	HUWE1 AGO1 SACS HERC2 SEC23A	6.15e-05	80	105	5	int:ATOH1
Interaction	TRIM28 interactions	CAND1 CAND2 HDAC4 COPB1 AGR2 PTPN23 HUWE1 LIN28A MAP3K4 ZNF557 ZNF419 TMX1 IGF2BP3 CYREN MIDN MTOR PGLS DNAH5 IQGAP3 ATP5F1A	6.55e-05	1474	105	20	int:TRIM28
Cytoband	7q35	CTAGE6 CTAGE8 CTAGE15 CTAGE4	8.36e-06	55	106	4	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	CTAGE6 CTAGE8 CTAGE15 CTAGE4	1.73e-05	66	106	4	chr7q35
GeneFamily	CTAGE family	CTAGE9 CTAGE6 CTAGE8 CTAGE15 CTAGE4	1.62e-09	15	66	5	907
GeneFamily	Protein disulfide isomerases	AGR2 AGR3 TMX1 ERP29	9.25e-07	21	66	4	692
GeneFamily	Dyneins, axonemal	DNAH5 DNAH9	1.72e-03	17	66	2	536
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC4 ZNF385A GSR PGR RANGRF RAPGEF3 NOTCH3	1.95e-07	173	106	7	5d7c53c6d1cdd385e44b79b82faec901747d1736
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC4 ZNF385A GSR PGR RANGRF RAPGEF3 NOTCH3	2.02e-07	174	106	7	9eab43885496b8586f8ec5b4bcb1fd5b209218e5
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AMPD2 PEX10 PGR SACS ANKAR NOTCH3	1.32e-06	145	106	6	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	AGR2 CAPS AGR3 SHANK2 DNAH5 DNAH9	7.09e-06	194	106	6	958e648138676d46698090b4046cb484083ae449
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	AGR2 CAPS AGR3 SHANK2 DNAH5 DNAH9	7.52e-06	196	106	6	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	AGR2 CAPS AGR3 SHANK2 DNAH5 DNAH9	7.52e-06	196	106	6	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	AGR2 CAPS AGR3 SHANK2 DNAH5 DNAH9	7.52e-06	196	106	6	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CYP1B1 ZNF385A PGR ATXN7 WDR90	1.93e-05	137	106	5	b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2B ACSS1 ZNF385A SSC5D ALDOC	4.97e-05	167	106	5	2184c2760b6142e62124a2454a552723e20d4f61
ToppCell	control-Epithelial-Ciliated-diff\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FOXD2 AGR2 CAPS AGR3 DNAH5	5.41e-05	170	106	5	334c4103eb6e021766f5638a4ab14b59ad085ac7
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Cilia-bearing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	AMPD2 KMT2B EXD3 AGO1 NNT	5.87e-05	173	106	5	d4cbeae262abfa30d8c5452285d3261a96875610
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGR2 CAPS AGR3 DNAH5 DNAH9	6.37e-05	176	106	5	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL25A1 PGR SSC5D MICU3 NOTCH3	7.27e-05	181	106	5	a2058d658f07ab6f0a28d2622f3090b4cde6f763
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL25A1 PGR SSC5D MICU3 NOTCH3	7.27e-05	181	106	5	526e858a848470b6d2d5248788004d9735ed3add
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	HECTD4 SHANK2 PPP6R2 ATP4A VAV2	8.06e-05	185	106	5	1d874608aa2062024323512f68889219471b2f00
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	AGR2 CAPS AGR3 SHANK2 DNAH5	9.60e-05	192	106	5	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGR2 CAPS AGR3 DNAH5 DNAH9	9.60e-05	192	106	5	6c269d2426f76559d2ed3bf2169eb4be5fc7ad6d
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	CAPS AGR3 SHANK2 DNAH5 DNAH9	9.60e-05	192	106	5	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	ASK452-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	AGR2 CAPS AGR3 DNAH5 DNAH9	9.84e-05	193	106	5	c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid\|TCGA-Endometrium / Sample_Type by Project: Shred V9	CAPS NCLN GSR DECR2 MVD	9.84e-05	193	106	5	3465352298b1fc9d75af4c2fdd91ad7990cbc901
ToppCell	ASK452-Epithelial-Ciliated\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	AGR2 CAPS AGR3 DNAH5 DNAH9	1.01e-04	194	106	5	5aeb44657ab6f61b1abf98af28d3397d8e44c1aa
ToppCell	wk_15-18-Epithelial-Proximal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	AGR2 CAPS AGR3 DNAH5 DNAH9	1.01e-04	194	106	5	b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CAPS AGR3 SHANK2 DNAH5 DNAH9	1.03e-04	195	106	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CAPS AGR3 SHANK2 DNAH5 DNAH9	1.03e-04	195	106	5	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	15-Airway-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	AGR2 CAPS AGR3 SHANK2 DNAH5	1.03e-04	195	106	5	cd0af7e260e4f0c5a9ecdfa93619f37b2a9308a5
ToppCell	343B\|World / Donor, Lineage, Cell class and subclass (all cells)	AGR2 CAPS AGR3 ERG28 DNAH5	1.03e-04	195	106	5	2290911fde6efacfa38b985a2541322968bee42d
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CAPS AGR3 SHANK2 DNAH5 DNAH9	1.03e-04	195	106	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	3'-Distal_airway-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGR2 CAPS AGR3 DNAH5 DNAH9	1.03e-04	195	106	5	72fa2ba064055e2fee2b2cb8633c8f9a3c4373da
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGR2 CAPS AGR3 DNAH5 DNAH9	1.06e-04	196	106	5	1386003f5d885f0ea080934f7e05fe05f142a3d5
ToppCell	15-Trachea\|15 / Age, Tissue, Lineage and Cell class	AGR2 CAPS AGR3 DNAH5 DNAH9	1.06e-04	196	106	5	fd17403422cf95c24f6be1c2d78764bb352f7f2e
ToppCell	wk_20-22-Epithelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	AGR2 CAPS AGR3 DNAH5 DNAH9	1.08e-04	197	106	5	468071c1911cdf8e8806a78dbceb95379e28ae91
ToppCell	COVID-19-Epithelial\|COVID-19 / Condition, Lineage and Cell class	AGR2 CAPS AGR3 DNAH5 DNAH9	1.08e-04	197	106	5	18fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell	BL-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 AGR2 CAPS AGR3 DNAH5	1.11e-04	198	106	5	6218a25b94d5fa2c69880539adf9c63bfe52dcd3
ToppCell	wk_20-22-Epithelial-Proximal_epithelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	AGR2 CAPS AGR3 DNAH5 DNAH9	1.11e-04	198	106	5	16c54b884500066ade05a406915f9569ca8abdfc
ToppCell	18-Airway\|18 / Age, Tissue, Lineage and Cell class	AGR2 CAPS AGR3 MIDN DNAH5	1.11e-04	198	106	5	3cdfcc6445858c3c54058bbd90b20b88b1771cca
ToppCell	18-Airway-Epithelial\|Airway / Age, Tissue, Lineage and Cell class	AGR2 CAPS AGR3 DNAH5 DNAH9	1.11e-04	198	106	5	be200dc5b9d95c2d37998b29c59418f0ba68d2bb
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP32 AGR2 GSR DNAH5 DNAH9	1.11e-04	198	106	5	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	AGR2 CAPS AGR3 DNAH5 DNAH9	1.14e-04	199	106	5	b974b495cabbcc3934936cec846c0e2442a70ac3
ToppCell	severe-Myeloid-Neutrophils_4\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	KREMEN1 IMPDH1 MIDN ALDOA SMAP2	1.14e-04	199	106	5	50242666def13e5d4149c563ae000d6768f086f7
ToppCell	NS-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 AGR2 CAPS AGR3 DNAH5	1.14e-04	199	106	5	d64adb68502be596ce55fb2cb63fe1cfa2c5f8ba
ToppCell	PSB-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP32 AGR2 CAPS AGR3 DNAH5	1.14e-04	199	106	5	58dcb0eedafa8629585dc99e53147e2287f49689
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CAPS AGR3 WDR90 DNAH5 DNAH9	1.16e-04	200	106	5	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	Biopsy_IPF-Epithelial-Differentiating_Ciliated\|Biopsy_IPF / Sample group, Lineage and Cell type	AGR2 CAPS AGR3 DNAH5 DNAH9	1.16e-04	200	106	5	8dfce65e417d6dcacb871d93d1539cdf807002fe
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	ZNF507 PEX10 ZNF385A ALDOC VAV2	1.16e-04	200	106	5	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	CAPS AGR3 WDR90 DNAH5 DNAH9	1.16e-04	200	106	5	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	Tracheal-10x3prime_v2-Epithelial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	AGR2 CAPS AGR3 DNAH5 DNAH9	1.16e-04	200	106	5	e1da1b15d2ca06796ee1ab7cef586ae0b4dc0a0a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Mesenchymal-Unfolded_protein_responsible_cell\|2m / Sample Type, Dataset, Time_group, and Cell type.	COPB1 AGR2 NOL7 ALDOA ALDOC	1.16e-04	200	106	5	1b08c1be05e2a6a05d8ea35d9a745c4b1809a1b2
ToppCell	Biopsy_IPF\|World / Sample group, Lineage and Cell type	CAPS AGR3 ALDOA DNAH5 DNAH9	1.16e-04	200	106	5	4de8c4789fb64250cb1dca94c108d39ab119bab4
ToppCell	Biopsy_IPF-Epithelial\|Biopsy_IPF / Sample group, Lineage and Cell type	AGR2 CAPS AGR3 DNAH5 DNAH9	1.16e-04	200	106	5	76f1ac00b34d07057d8da03d276438b719b46b1d
Drug	quinocetone	CYP1B1 CYP11B2 GSR PGR ERG28 PGLS ALDOA ALDOC ATP5F1A MVD	1.91e-07	248	103	10	ctd:C502851
Drug	3,4-dihydro-2(1H)-quinolinone	CYP11B2 ALDOA ALDOC	1.05e-05	10	103	3	CID000064796
Drug	dihydropteridine	ALDOA QDPR ALDOC	1.92e-05	12	103	3	CID000000167
Drug	Ichiba acid	ALDOA ALDOC	2.03e-05	2	103	2	CID000440403
Drug	3-HM	ALDOA ALDOC	2.03e-05	2	103	2	CID000439464
Drug	bromohydroxyacetone phosphate	ALDOA ALDOC	2.03e-05	2	103	2	CID000152675
Drug	anthracene diol	ALDOA ALDOC	2.03e-05	2	103	2	CID000155464
Drug	alternariol	CYP11B2 GSR PGR MTOR	2.59e-05	38	103	4	ctd:C005197
Drug	Naftifine hydrochloride [65473-14-5]; Down 200; 12.4uM; MCF7; HT_HG-U133A	NCLN AGO1 SACS NUP210 PHLPP1 PPP6R2 NNT	3.31e-05	198	103	7	7032_DN
Drug	Josamycin [16846-24-5]; Down 200; 4.8uM; PC3; HG-U133A	NCLN MAP3K4 ZNF419 MINDY3 TELO2 DECR2 PPP6R2	3.42e-05	199	103	7	1950_DN
Drug	A-272	ALDOA ALDOC NNT	3.93e-05	15	103	3	CID004488325
Drug	acetol phosphate	ALDOA ALDOC	6.06e-05	3	103	2	CID000150865
Drug	3,3,3-trifluoropropanoic acid	ALDOA ALDOC	6.06e-05	3	103	2	CID002777972
Drug	4-hydroxy-9-fluorenone	ALDOA ALDOC	6.06e-05	3	103	2	CID000016139
Drug	Htfp	ALDOA ALDOC	6.06e-05	3	103	2	CID000125055
Drug	DIDIT	ALDOA ALDOC	6.06e-05	3	103	2	CID000196082
Drug	2-keto-3-deoxy- l-lyxonate	ALDOA ALDOC	6.06e-05	3	103	2	CID000192781
Drug	4-fluorothreonine	ALDOA ALDOC	6.06e-05	3	103	2	CID000128057
Drug	(4S,7R,8R,9R,13Z,16S)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-1-oxacyclohexadec-13-ene-2,6-dione	ALDOA ALDOC	6.06e-05	3	103	2	CID009869661
Drug	androisoxazole	ALDOA ALDOC	6.06e-05	3	103	2	CID000009676
Drug	2-keto-3-bromobutyrate	ALDOA ALDOC	6.06e-05	3	103	2	CID000191968
Drug	3-isochromanone	ALDOA ALDOC	6.06e-05	3	103	2	CID000078092
Drug	5-deoxy-5-fluoro-L-sorbose	ALDOA ALDOC	6.06e-05	3	103	2	CID000191809
Drug	D-ribulose-1-p	ALDOA ALDOC	6.06e-05	3	103	2	CID000000615
Drug	AC1L19ID	ALDOA ALDOC	6.06e-05	3	103	2	CID000000560
Drug	4-hydroxy-2-ketopimelate	ALDOA ALDOC	6.06e-05	3	103	2	CID000000553
Drug	AC1L19F1	ALDOA ALDOC	6.06e-05	3	103	2	CID000000519
Drug	C11 -427	ALDOA ALDOC	6.06e-05	3	103	2	CID000443195
Drug	malate	HDAC4 GSR SIGLEC1 ALDOA ALDOC NNT ATP5F1A	6.27e-05	219	103	7	CID000000525
Drug	hex-2-ulose	AMPD2 MFF ATXN7 ALDOA ALDOC	6.51e-05	93	103	5	CID000001101
Drug	GTP - Na	ARHGAP32 AMPD2 IMPDH1 COPB1 XPO1 TUBB1 ADRB3 RAPGEF3 MTOR NUP210 QDPR IQGAP3 VAV2 SEC23A	7.05e-05	923	103	14	CID000000762
Drug	rifampicin	CYP1B1 CYP11B2 AGR3 PGR ATXN7 MTOR PGLS QDPR	7.65e-05	306	103	8	CID005381226
Drug	beta-NADP	CYP1B1 CYP11B2 ACSS1 GSR PGLS DECR2 ALDOA QDPR ALDOC NNT	7.68e-05	490	103	10	CID000000929
Drug	9-fluorenone-1-carboxylic acid	ALDOA ALDOC	1.21e-04	4	103	2	CID000074083
Drug	formylacetate	ALDOA ALDOC	1.21e-04	4	103	2	CID000075269
Drug	dihydroxyacetone sulfate	ALDOA ALDOC	1.21e-04	4	103	2	CID000439751
Drug	AC1L9A8P	ALDOA ALDOC	1.21e-04	4	103	2	CID000440943
Drug	C06441	ALDOA ALDOC	1.21e-04	4	103	2	CID000441020
Drug	3-hydroxy-1-indanone	ALDOA ALDOC	1.21e-04	4	103	2	CID000176448
Drug	l-123	ALDOA ALDOC	1.21e-04	4	103	2	CID000093552
Drug	phenanthrene trans-3,4-dihydrodiol	ALDOA ALDOC	1.21e-04	4	103	2	CID000119398
Drug	DHMP	ALDOA ALDOC	1.21e-04	4	103	2	CID000098784
Drug	methiin	SACS MTOR	1.21e-04	4	103	2	CID000082142
Drug	AC1L8WWP	TUBB1 MTOR ALDOA ALDOC	1.21e-04	56	103	4	CID000388944
Drug	diphenylacetylene	AMPD2 ALDOA ALDOC	1.30e-04	22	103	3	CID000010390
Drug	silver nanoparticles	COPB1 AGR2 GSR ATXN7 MTOR QDPR	1.33e-04	172	103	6	CID000023954
Drug	reduced diphosphopyridine nucleotide	IMPDH1 CYP11B2 ACSS1 GSR ALDOA QDPR ALDOC NNT	1.65e-04	342	103	8	CID000000928
Drug	mpMap	TUBB1 ALDOA ALDOC	1.92e-04	25	103	3	CID000100806
Drug	Sanguinarine [2447-54-3]; Down 200; 12uM; HL60; HT_HG-U133A	CAND1 MINDY3 ERG28 AGO1 SACS NUP210	1.98e-04	185	103	6	2927_DN
Drug	1,3-dioxan-5-one	ALDOA ALDOC	2.01e-04	5	103	2	CID009793707
Drug	AC1L4F2K	ALDOA ALDOC	2.01e-04	5	103	2	CID000184526
Drug	gamma-oxalocitramalate	ALDOA ALDOC	2.01e-04	5	103	2	CID000000130
Drug	2,3-dihydroxy-p-cumate	ALDOA ALDOC	2.01e-04	5	103	2	CID000029587
Drug	f-3p	ALDOA ALDOC	2.01e-04	5	103	2	CID015991581
Drug	AC1NX490	ALDOA ALDOC	2.01e-04	5	103	2	CID005743230
Drug	alpha-methylserine	ALDOA ALDOC	2.01e-04	5	103	2	CID000094309
Drug	phosphoglycollamide	ALDOA ALDOC	2.01e-04	5	103	2	CID000191768
Drug	D-erythrulose 1-phosphate	ALDOA ALDOC	2.01e-04	5	103	2	CID000152153
Drug	5-nitro-2-furoic acid	GSR NNT	2.01e-04	5	103	2	CID000012577
Drug	patuletin	GSR MTOR	2.01e-04	5	103	2	CID005281678
Drug	hydroxypyruvaldehyde phosphate	ALDOA ALDOC	2.01e-04	5	103	2	CID000193787
Disease	seasonality measurement, vitamin D measurement	COPB1 SEC23A	9.98e-05	5	94	2	EFO_0004631, EFO_0006876
Disease	dilated cardiomyopathy 1H (is_implicated_in)	CYP11B2 ADRB3	9.98e-05	5	94	2	DOID:0110429 (is_implicated_in)
Disease	dietary heme iron intake measurement, type 2 diabetes mellitus	AGR2 AGR3	1.49e-04	6	94	2	EFO_0008355, MONDO_0005148
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A4 ATP4A	2.09e-04	7	94	2	DOID:0060178 (implicated_via_orthology)
Disease	Enzymopathy	GSR ALDOA	5.42e-04	11	94	2	C0520572
Disease	Intellectual Disability	HDAC4 PTPN23 PPP2R5D AGO1 SHANK2 SACS MTOR	5.76e-04	447	94	7	C3714756
Disease	nervous system disease (implicated_via_orthology)	ATP1A4 ATP4A	6.49e-04	12	94	2	DOID:863 (implicated_via_orthology)
Disease	Situs ambiguus	DNAH5 DNAH9	1.03e-03	15	94	2	C0266642
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	DIP2B KMT2B	1.32e-03	17	94	2	DOID:0060307 (is_implicated_in)
Disease	nevus count	CYP1B1 HDAC4	1.49e-03	18	94	2	EFO_0004632
Disease	Contact Dermatitis	CYP1B1 HDAC4 GSR	1.53e-03	71	94	3	C0011616
Disease	Contact hypersensitivity	CYP1B1 HDAC4 GSR	1.53e-03	71	94	3	C0162351
Disease	non-melanoma skin carcinoma	CYP1B1 ULBP3 PSORS1C1 HERC2 NNT	1.61e-03	265	94	5	EFO_0009260
Disease	Breast Carcinoma	CYP1B1 AGR2 PGR MTOR HERC2 ALDOA NOTCH3	1.68e-03	538	94	7	C0678222
Disease	polycystic ovary syndrome (biomarker_via_orthology)	PGR ADRB3	2.03e-03	21	94	2	DOID:11612 (biomarker_via_orthology)
Disease	progression free survival, ovarian serous carcinoma	KREMEN1 IQGAP3	2.23e-03	22	94	2	EFO_0004920, EFO_1001516
Disease	congestive heart failure (is_marker_for)	ADRB3 RAPGEF3 MTOR	2.31e-03	82	94	3	DOID:6000 (is_marker_for)
Disease	Impaired glucose tolerance	CYP1B1 RAPGEF3	2.87e-03	25	94	2	C0271650
Disease	Left Ventricular Hypertrophy	ADRB3 MTOR	2.87e-03	25	94	2	C0149721
Disease	nevus count, cutaneous melanoma	CYP1B1 HDAC4 HERC2	3.11e-03	91	94	3	EFO_0000389, EFO_0004632

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLLPSPLAVAAVMAA	ZNF385A	326	Q96PM9
PRIMFVDPSLTVRAD	AGR2	126	O95994
DRVAIYMPVSPLAVA	ACSS1	166	Q9NUB1
ALRPPMSQAREAVIA	CAPS	171	Q13938
RVVAALPESMRPDEN	CTAGE4	21	Q8IX94
RVVAALPESMRPDEN	CTAGE6	21	Q86UF2
RVVAALPESMRPDEN	CTAGE8	21	P0CG41
RVVAALPESMRPDEN	CTAGE9	21	A4FU28
RVVAALPESMRPDEN	CTAGE15	21	A4D2H0
VSMLARELPAAVAPA	PGLS	51	O95336
MATVTALRRTVPPAV	ALDOC	251	P09972
VPRIMFVDPSLTVRA	AGR3	116	Q8TD06
MATVTALRRTVPPAV	ALDOA	251	P04075
MAAAVPRAAFLSPLL	ERP29	1	P30040
PEPAALTRALSRAMA	GSR	31	P00390
PVPLESVQALDVAMR	AGO1	151	Q9UL18
SDNAARVLPIMFPAL	PPP2R5D	436	Q14738
AADLVMGLLVVPPAA	ADRB3	81	P13945
CRSDSPAVAAVVPAM	AMPD2	41	Q01433
AAIAVLPVTLDTPMN	QDPR	176	P09417
MLSVRVAAAVVRALP	ATP5F1A	1	P25705
MAATNRPDIIDPAIL	NVL	721	O15381
PELAMAVRPATTTVD	PTPN23	871	Q9H3S7
VRLMAPTPVLISSAA	PUM2	461	Q8TB72
GAVVIILPRAMAAVP	NCLN	106	Q969V3
ILPRAMAAVPQDVVR	NCLN	111	Q969V3
EVLMAAVGAPRFPSA	SLC16A8	366	O95907
AILPMGAIDVSDLRP	RANGRF	16	Q9HD47
AAAVSRLEQTPMPII	PM20D1	271	Q6GTS8
MAPAAASPPEVIRAA	PEX10	1	O60683
DAIAMEGAIPPLVAL	ANKAR	901	Q7Z5J8
PARPVAVLAQDTSMV	NUP210	296	Q8TEM1
RMAAVPVAAARLPAT	CYREN	36	Q9BWK5
MALVAPEAPSEQARR	MINDY3	296	Q9H8M7
MPIASEFAPDVVLVS	HDAC4	916	P56524
MAAPEAEVLSSAAVP	MAD2L1BP	1	Q15013
AAVAATAPGPEMVER	KMT5A	61	Q9NQR1
RAAFPSPTAAEMAEI	MFF	16	Q9GZY8
VAAVREGMARVVPVP	HERC2	4646	O95714
AMRAVAALLTIPEAE	CAND1	1176	Q86VP6
VVRGAALMAPLPVFI	OR51E1	151	Q8TCB6
SVRFPDMAANVIPVL	COPB1	391	P53618
MPPCAVLAALLSVVA	COL25A1	31	Q9BXS0
AAPTIGVLAPLMVAS	ERG28	101	Q9UKR5
VAADIRVAPAMALTP	NOTCH3	1756	Q9UM47
DVRAPPAVMAAVDQA	DECR2	86	Q9NUI1
MAERGLEPSPAAVAA	DIP2B	1	Q9P265
RPAPLSAELQAALAM	MVD	346	P53602
MAPPAARLALLSAAA	KREMEN1	1	Q96MU8
QARAMVPEDVPRLSA	KMT2B	881	Q9UMN6
MLPIPVAAAKETVAI	MICU3	116	Q86XE3
EAMAAALVARGPPLE	NFKBIL1	311	Q9UBC1
MASRQPEVPALEASA	KIAA1191	1	Q96A73
GSAPVMAVVRLLAEI	HECTD4	1846	Q9Y4D8
TLSAMARGADVPEIP	ARHGAP32	71	A7KAX9
VLAVMPPDIAAEAQA	HUWE1	3081	Q7Z6Z7
SAAAMATVGERRPLP	ATXN7	71	O15265
VVAIIVGTPAFRAPM	GPR3	61	P46089
IAPAEAPDAKVRMVI	IGF2BP3	441	O00425
NPAVVAPDAFDIVAM	IQGAP3	1181	Q86VI3
SEVMTPRIELVVAPA	IMPDH1	176	P20839
PRASRAPASAEAMVD	NOL7	6	Q9UMY1
SAPRVALVEQDAPMA	PGR	276	P06401
TLPDVMLLARPAAVC	GARIN6	81	Q8NEG0
LDPRPLTVVAVANVM	CYP1B1	191	Q16678
PKAVQRFLPMVDAVA	CYP11B2	151	P19099
PPLAVSNVSAAVMVL	DNAH9	3181	Q9NYC9
SEPLVPSAAALARMD	FAM83H	281	Q6ZRV2
AMRAVAALLTIPEVG	CAND2	1181	O75155
FVPIIGIAMPLSSRD	SACS	416	Q9NZJ4
FAGLVSMIDPPRATV	ATP4A	596	P20648
RASVTLAIPNIVMAP	DNAH5	1011	Q8TE73
ALAVAVPLGPIMAVT	PPP6R2	921	O75170
QALMELAPASAPARD	HGH1	66	Q9BTY7
EPMLAVGLSPALTAV	MTOR	506	P42345
VLAMLTAPALAPVAG	FOXD2	451	O60548
MREAAAALVPPPAFA	MAP3K4	1	Q9Y6R4
LLAAAPVVPVMAAQV	NUTM2D	176	Q5VT03
ELGPAAEAAPMSLAI	MIDN	21	Q504T8
ASDLVVKVRAPMVNP	NNT	121	Q13423
DIAMVLAQDPAPATV	THAP8	246	Q8NA92
VAVCDIPPRGLSMAA	TUBB1	351	Q9H4B7
MEPAPSEVRLAVREA	TELO2	1	Q9Y4R8
RVMACEPPALVELVA	SSC5D	1481	A1L4H1
ATRMVVPVAALFTPL	SEC23A	31	Q15436
PSRAAENMAVEPRVA	SHANK2	781	Q9UPX8
FVGLISMIDPPRAAV	ATP1A4	591	Q13733
MAAAASPAILPRLAI	ULBP3	1	Q9BZM4
LPVTASVREVMAALA	RAPGEF3	576	O95398
NVPAAREPEVLSTMA	XPO1	791	O14980
PCLSVAPALVITMAA	ZNF488	6	Q96MN9
LRVAADMVCPDAPAS	WDR90	821	Q96KV7
MAEPRRVAFISLSPV	UBN2	1	Q6ZU65
TAPVMDLLGLDAPVA	SMAP2	181	Q8WU79
LFASVLPMAPEEAAR	PSORS1C1	96	Q9UIG5
PAPSMAVVAVLESTL	PXK	361	Q7Z7A4
PTGAAASAPVMLRVL	SIGLEC1	1516	Q9BZZ2
AAEALVTMPIRAAEL	ZNF507	496	Q8TCN5
MEPAAAATVQRLPEL	PHLPP1	1	O60346
SPLRLVLSPADMAAV	VAV2	226	P52735
MAAVVLPPTAASQRE	ZNF557	1	Q8N988
MAAAALRDPAQVPVA	ZNF419	1	Q96HQ0
MAPSGSLAVPLAVLV	TMX1	1	Q9H3N1
LDSRVPLTAVAVMPA	WDR81	1736	Q562E7
RPGVAPERAEVVMAA	ZNF784	171	Q8NCA9
LSMTARAGVALDPPV	LIN28A	56	Q9H9Z2
HRQMRVASVPAPAVD	EXD3	496	Q8N9H8