Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	glutamine family amino acid metabolic process	PPAT MECP2 ATP2B4 GFPT1	2.10e-05	80	42	4	GO:0009064
GeneOntologyBiologicalProcess	glutamine metabolic process	PPAT MECP2 GFPT1	3.07e-05	30	42	3	GO:0006541
GeneOntologyCellularComponent	chromatin	IRF2 GRHL1 BRD3 CHD6 BBX ATRX RRP1B BAZ2B MECP2 TCF7L1 FAM111B	1.50e-04	1480	43	11	GO:0000785
Domain	GATASE_TYPE_2	PPAT GFPT1	5.15e-05	5	43	2	PS51278
Domain	GATase_2_dom	PPAT GFPT1	5.15e-05	5	43	2	IPR017932
Domain	-	BAZ2B MECP2	1.44e-04	8	43	2	3.30.890.10
Domain	Methyl_CpG_DNA-bd	BAZ2B MECP2	2.81e-04	11	43	2	IPR001739
Domain	MBD	BAZ2B MECP2	2.81e-04	11	43	2	PF01429
Domain	MBD	BAZ2B MECP2	2.81e-04	11	43	2	SM00391
Domain	MBD	BAZ2B MECP2	2.81e-04	11	43	2	PS50982
Domain	DNA-bd_dom	BAZ2B MECP2	2.81e-04	11	43	2	IPR016177
Domain	Znf_FYVE_PHD	ATRX BAZ2B PHF3 RPH3A	3.58e-04	147	43	4	IPR011011
Domain	G_patch	RBM10 GPATCH1	1.27e-03	23	43	2	SM00443
Domain	G_patch_dom	RBM10 GPATCH1	1.27e-03	23	43	2	IPR000467
Domain	G-patch	RBM10 GPATCH1	1.27e-03	23	43	2	PF01585
Domain	G_PATCH	RBM10 GPATCH1	1.27e-03	23	43	2	PS50174
Domain	ZF_PHD_2	ATRX BAZ2B PHF3	1.36e-03	95	43	3	PS50016
Domain	-	PPAT GFPT1	1.38e-03	24	43	2	3.60.20.10
Domain	ZF_PHD_1	ATRX BAZ2B PHF3	1.40e-03	96	43	3	PS01359
Domain	Bromodomain_CS	BRD3 BAZ2B	1.62e-03	26	43	2	IPR018359
Domain	SNF2_N	CHD6 ATRX	2.46e-03	32	43	2	PF00176
Domain	SNF2_N	CHD6 ATRX	2.46e-03	32	43	2	IPR000330
Domain	Ntn_hydrolases_N	PPAT GFPT1	2.61e-03	33	43	2	IPR029055
Domain	BROMODOMAIN_1	BRD3 BAZ2B	3.28e-03	37	43	2	PS00633
Domain	Bromodomain	BRD3 BAZ2B	3.45e-03	38	43	2	PF00439
Domain	BROMODOMAIN_2	BRD3 BAZ2B	4.01e-03	41	43	2	PS50014
Domain	BROMO	BRD3 BAZ2B	4.20e-03	42	43	2	SM00297
Domain	Bromodomain	BRD3 BAZ2B	4.20e-03	42	43	2	IPR001487
Domain	-	BRD3 BAZ2B	4.20e-03	42	43	2	1.20.920.10
Domain	HMG_box	BBX TCF7L1	6.62e-03	53	43	2	PF00505
Domain	HMG_BOX_2	BBX TCF7L1	6.87e-03	54	43	2	PS50118
Domain	HMG	BBX TCF7L1	6.87e-03	54	43	2	SM00398
Domain	-	PSMC5 CHD6 SAMD9L GNL3L ATRX N4BP2	6.88e-03	746	43	6	3.40.50.300
Domain	-	BBX TCF7L1	7.12e-03	55	43	2	1.10.30.10
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SLTM PPIG BRD3 CHD6 BBX ATRX RRP1B BAZ2B MECP2 PHF3 RBM10 GPATCH1 KNOP1 ARID5B	5.15e-10	1294	45	14	30804502
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BRD3 CHD6 GNL3L BBX ATRX RRP1B BAZ2B MECP2 PHF3 KNOP1	4.56e-09	608	45	10	36089195
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SLTM BBX ATRX RRP1B BAZ2B MECP2 PHF3 ZC3H15 RBM10 GPATCH1 KNOP1	2.70e-08	954	45	11	36373674
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BBX ATRX RRP1B MECP2 PHF3 RBM10 GPATCH1	7.64e-08	283	45	7	30585729
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SLTM PPIG BRD3 CHD6 BBX RRP1B MECP2 ZC3H15 RBM10 MRPL48 KNOP1	9.67e-08	1082	45	11	38697112
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	SLTM ATRX RRP1B RBM10 KNOP1	1.39e-06	148	45	5	32538781
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	SLTM BRD3 CHD6 GNL3L BBX MECP2 ZC3H15 FAM111B	1.58e-06	645	45	8	25281560
Pubmed	Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation.	ATRX MECP2	1.64e-06	2	45	2	22129561
Pubmed	Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse.	PER2 MECP2	1.64e-06	2	45	2	26456390
Pubmed	Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT.	PER2 MECP2	1.64e-06	2	45	2	25779967
Pubmed	Pathogenic Variants in STXBP1 and in Genes for GABAa Receptor Subunities Cause Atypical Rett/Rett-like Phenotypes.	STXBP1 MECP2	1.64e-06	2	45	2	31344879
Pubmed	ATRX Contributes to MeCP2-Mediated Pericentric Heterochromatin Organization during Neural Differentiation.	ATRX MECP2	1.64e-06	2	45	2	31671722
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FRA10AC1 BRD3 CHD6 BBX STXBP1 ATRX TRDN MECP2 FAM186A N4BP2 KNOP1	1.66e-06	1442	45	11	35575683
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SLTM BRD3 CHD6 ATRX MECP2 N4BP2 KNOP1	2.26e-06	469	45	7	27634302
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SLTM PPIG BBX RRP1B ZC3H15 RBM10 MRPL48 KNOP1	3.31e-06	713	45	8	29802200
Pubmed	Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation.	ATRX MECP2	4.91e-06	3	45	2	22500635
Pubmed	Chromatin context and ncRNA highlight targets of MeCP2 in brain.	ATRX MECP2	4.91e-06	3	45	2	24270455
Pubmed	Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.	ATRX MECP2	4.91e-06	3	45	2	24990380
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SLTM GRHL1 BRD3 BBX TCF7L1 ZC3H15 RBM10 ARID5B	8.26e-06	808	45	8	20412781
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	EVI5 FRA10AC1 BRD3 ATP2B4 RBM10 ARID5B	9.02e-06	378	45	6	34315543
Pubmed	Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.	ATRX MECP2	9.81e-06	4	45	2	17296936
Pubmed	miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock.	PER2 MECP2	9.81e-06	4	45	2	28423315
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	CHD6 GNL3L BBX RRP1B	1.23e-05	109	45	4	33554859
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	SLTM PSMC5 PPIG GNL3L RRP1B BAZ2B	1.45e-05	411	45	6	35182466
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BRD3 CHD6 GNL3L BBX ATRX RRP1B MECP2 PHF3 ZC3H15 KNOP1	1.70e-05	1497	45	10	31527615
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ATRX RRP1B PHF3 RBM10 GFPT1 GPATCH1	2.13e-05	440	45	6	34244565
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PSMC5 GNL3L ATRX ZC3H15 RBM10 GFPT1 GPATCH1 KNOP1	2.35e-05	934	45	8	33916271
Pubmed	Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.	ATRX MECP2	3.42e-05	7	45	2	23362347
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	BRD3 CHD6 SAMD9L CFAP418 BAZ2B GFPT1 ARID5B	4.17e-05	736	45	7	29676528
Pubmed	High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.	BBX TCF7L1 ARID5B	5.35e-05	56	45	3	19591821
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PPIG BRD3 ATRX MECP2 PHF3 RBM10 CXADR	5.72e-05	774	45	7	15302935
Pubmed	ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain.	ATRX MECP2	5.86e-05	9	45	2	20159591
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	SLTM ATRX RRP1B MECP2 KNOP1	8.69e-05	349	45	5	25665578
Pubmed	The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.	SLTM BRD3 MECP2	8.75e-05	66	45	3	32051553
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	SLTM BRD3 GNL3L RRP1B PHF3 RBM10 KNOP1	1.00e-04	847	45	7	35850772
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SLTM PPIG SAMD9L RRP1B PHF3	1.02e-04	361	45	5	26167880
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	SLTM CHD6 GFPT1 CXADR ARID5B	1.04e-04	363	45	5	14691545
Pubmed	SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.	STXBP1 RPH3A	1.07e-04	12	45	2	17803915
Pubmed	ATRX directs binding of PRC2 to Xist RNA and Polycomb targets.	ATRX MECP2	1.07e-04	12	45	2	25417162
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	PSMC5 RRP1B RBM10 GFPT1 MRPL48 KNOP1	1.19e-04	601	45	6	33658012
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	PHF3 RPH3A	1.47e-04	14	45	2	28263302
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	BAZ2B WDR87	1.47e-04	14	45	2	28878358
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	CHD6 STXBP1 TRDN HBEGF GFPT1 ARID5B	1.65e-04	638	45	6	31182584
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	GNL3L BBX STXBP1 MECP2 KNOP1	1.84e-04	410	45	5	26949251
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SLTM GNL3L RRP1B MECP2 PHF3 ZC3H15 GFPT1 KNOP1	1.87e-04	1257	45	8	36526897
Pubmed	Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.	STXBP1 RPH3A	1.94e-04	16	45	2	12590134
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	PSMC5 PPIG BRD3 STXBP1 RBM10 GFPT1	2.06e-04	665	45	6	30457570
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	PSMC5 ATP2B4 GFPT1 CXADR MRPL48	2.10e-04	422	45	5	27342126
Pubmed	Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.	ATRX MECP2	2.20e-04	17	45	2	14519686
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	ATRX MECP2	2.20e-04	17	45	2	19571810
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	SLTM ATRX TRDN	2.35e-04	92	45	3	15840729
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	BBX RESF1 PHF3 RBM10	2.36e-04	233	45	4	37704626
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	PSMC5 PPAT RRP1B ZC3H15 CXADR KNOP1	2.80e-04	704	45	6	32994395
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	GNL3L RRP1B ZC3H15 KNOP1	2.85e-04	245	45	4	35652658
Pubmed	A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.	BBX PER2 TCF7L1	3.18e-04	102	45	3	19741146
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PPIG GNL3L RRP1B MECP2 ATP2B4 PHF3 GFPT1 KNOP1	3.35e-04	1371	45	8	36244648
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	RRP1B ZC3H15 GFPT1 BICC1 FAM111B	3.42e-04	469	45	5	37314180
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PSMC5 TMEM131 CHD6 GNL3L PHF3 N4BP2	3.47e-04	733	45	6	34672954
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	GRHL1 PHF3 RBM10 ARID5B	4.01e-04	268	45	4	33640491
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	RRP1B ZC3H15 RBM10	4.18e-04	112	45	3	28416769
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	PSMC5 PPIG GNL3L RRP1B RBM10	4.22e-04	491	45	5	36273042
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	SLTM PSMC5 GNL3L PPAT ATRX RRP1B ZC3H15 GFPT1	4.34e-04	1425	45	8	30948266
Pubmed	Human transcription factor protein interaction networks.	PSMC5 CHD6 BBX RESF1 ATRX RRP1B RBM10 ARID5B	4.42e-04	1429	45	8	35140242
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SLTM TMEM131 RESF1 ATRX BICC1 KNOP1 ARID5B	4.52e-04	1084	45	7	11544199
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	STXBP1 RPH3A	5.22e-04	26	45	2	17124501
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BRD3 GNL3L RESF1 MECP2 TCF7L1 ZC3H15 KNOP1	5.37e-04	1116	45	7	31753913
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TMEM131 ATRX RRP1B ATP2B4 ZC3H15 N4BP2 CXADR MRPL48	5.76e-04	1487	45	8	33957083
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	BRD3 BBX ATRX RRP1B MECP2	6.11e-04	533	45	5	30554943
Pubmed	A common variant in DRD3 receptor is associated with autism spectrum disorder.	PPIG PER2 MECP2	6.17e-04	128	45	3	19058789
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	RBM10 GPATCH1 KNOP1	6.46e-04	130	45	3	35545047
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	PSMC5 PPAT RRP1B N4BP2 RBM10	7.10e-04	551	45	5	34728620
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	RRP1B ZC3H15 RBM10 KNOP1	7.43e-04	316	45	4	31665637
Pubmed	miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.	STXBP1 MECP2	7.43e-04	31	45	2	37816598
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	PPIG TMEM131 N4BP2 GFPT1 CFAP97 GPATCH1	7.71e-04	853	45	6	28718761
Pubmed	Maternal diabetes alters transcriptional programs in the developing embryo.	ATRX CXADR	7.92e-04	32	45	2	19538749
Pubmed	HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.	IRF2 MECP2	7.92e-04	32	45	2	11748221
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	PPIG GNL3L RRP1B MECP2	8.73e-04	330	45	4	33301849
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RESF1 ATRX N4BP2 FAM111B ARID5B	9.49e-04	588	45	5	38580884
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	SLTM RRP1B BAZ2B PHF3	9.75e-04	340	45	4	29478914
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	CHD6 N4BP2 CFAP97	1.03e-03	153	45	3	10718198
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	SLTM RBM10 BICC1 GPATCH1	1.05e-03	347	45	4	16033648
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	CHD6 ATRX BAZ2B	1.11e-03	157	45	3	30186101
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	PSMC5 ATRX RBM10 GPATCH1	1.17e-03	357	45	4	37059091
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	SLTM RRP1B RBM10	1.22e-03	162	45	3	31363146
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TMEM131 CHD6 STXBP1 ATRX RPH3A GFPT1 ARID5B	1.23e-03	1285	45	7	35914814
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	RRP1B ZC3H15 RBM10	1.24e-03	163	45	3	22113938
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	STXBP1 ATP2B4 RPH3A	1.24e-03	163	45	3	16512683
Interaction	H3C3 interactions	BRD3 CHD6 GNL3L BBX ATRX RRP1B BAZ2B MECP2 PHF3 KNOP1	8.56e-08	495	44	10	int:H3C3
Interaction	ANAPC15 interactions	SLTM PPIG BBX PHF3 CFAP97 KNOP1	3.38e-07	128	44	6	int:ANAPC15
Interaction	H2BC8 interactions	BRD3 CHD6 GNL3L BBX ATRX MECP2 PHF3 KNOP1 ARID5B	3.47e-06	576	44	9	int:H2BC8
Interaction	NIFK interactions	BRD3 GNL3L BBX RRP1B MECP2 PHF3 MRPL48 KNOP1	3.70e-06	431	44	8	int:NIFK
Interaction	IFI6 interactions	SLTM PPIG BRD3 KNOP1	5.77e-06	54	44	4	int:IFI6
Interaction	NUP43 interactions	CHD6 GNL3L BBX RESF1 RRP1B BAZ2B MECP2 GPATCH1 KNOP1	6.73e-06	625	44	9	int:NUP43
Interaction	PIP4K2A interactions	SLTM PPIG BRD3 RRP1B MECP2 KNOP1	7.11e-06	216	44	6	int:PIP4K2A
Interaction	SMC5 interactions	SLTM BBX ATRX RRP1B BAZ2B MECP2 PHF3 ZC3H15 RBM10 GPATCH1 KNOP1	7.20e-06	1000	44	11	int:SMC5
Interaction	POLR1G interactions	BRD3 GNL3L BBX RRP1B BAZ2B MECP2 PHF3 KNOP1	9.33e-06	489	44	8	int:POLR1G
Interaction	MECP2 interactions	SLTM PPIG BRD3 CHD6 BBX ATRX RRP1B MECP2 ZC3H15 RBM10 MRPL48 KNOP1	1.36e-05	1287	44	12	int:MECP2
Interaction	CENPA interactions	BRD3 CHD6 BBX ATRX RRP1B MECP2 KNOP1	1.60e-05	377	44	7	int:CENPA
Interaction	MYCN interactions	SLTM PSMC5 PPIG GNL3L BBX RRP1B MECP2 PHF3 RBM10 GPATCH1 MRPL48 KNOP1	2.60e-05	1373	44	12	int:MYCN
Interaction	EMC1 interactions	PSMC5 TRDN MECP2 ATP2B4 GFPT1 CXADR MRPL48	3.10e-05	418	44	7	int:EMC1
Interaction	ZNF330 interactions	BRD3 GNL3L BBX RRP1B MECP2 PHF3 KNOP1	4.68e-05	446	44	7	int:ZNF330
Interaction	ZNF618 interactions	BRD3 PER2 MECP2	6.59e-05	36	44	3	int:ZNF618
Interaction	DDX23 interactions	SLTM PPIG RRP1B MECP2 PHF3 RBM10 KNOP1	7.44e-05	480	44	7	int:DDX23
Interaction	EXOSC4 interactions	SLTM RRP1B MECP2 MRPL48 KNOP1	7.61e-05	202	44	5	int:EXOSC4
Interaction	TACO1 interactions	SLTM RRP1B MECP2 PHF3 MRPL48 KNOP1	8.50e-05	336	44	6	int:TACO1
Interaction	POLR1E interactions	BRD3 CHD6 BBX RRP1B BAZ2B KNOP1	1.06e-04	350	44	6	int:POLR1E
Interaction	HMGN2 interactions	PPIG BRD3 CHD6 CFAP418 MECP2	1.19e-04	222	44	5	int:HMGN2
Interaction	ZCCHC10 interactions	FRA10AC1 PPIG CHD6 BBX GPATCH1	1.58e-04	236	44	5	int:ZCCHC10
Interaction	DOC2B interactions	STXBP1 RPH3A	2.07e-04	10	44	2	int:DOC2B
Interaction	UQCR11 interactions	SLTM PHF3 KNOP1	2.11e-04	53	44	3	int:UQCR11
Interaction	NAA40 interactions	PSMC5 GNL3L ATRX MECP2 ZC3H15 RBM10 GFPT1 GPATCH1 KNOP1	2.20e-04	978	44	9	int:NAA40
Interaction	SNRNP70 interactions	SLTM PPIG BBX RRP1B MECP2 ZC3H15 RBM10 MRPL48 KNOP1	2.30e-04	984	44	9	int:SNRNP70
Interaction	EPB41L3 interactions	PPIG BRD3 STXBP1 ATRX MECP2	3.05e-04	272	44	5	int:EPB41L3
Interaction	DOT1L interactions	SLTM BRD3 GNL3L ATRX RRP1B PHF3 RBM10 KNOP1	3.14e-04	807	44	8	int:DOT1L
Interaction	TBX5 interactions	PSMC5 GNL3L RRP1B BAZ2B	3.18e-04	150	44	4	int:TBX5
Interaction	NSD2 interactions	BRD3 ATRX MECP2 RBM10 KNOP1	3.37e-04	278	44	5	int:NSD2
Interaction	CSNK2B interactions	BRD3 PER2 ATRX RRP1B BAZ2B MECP2 CFAP97	3.77e-04	625	44	7	int:CSNK2B
Interaction	CEP19 interactions	SLTM EVI5 ZC3H15 GPATCH1	3.78e-04	157	44	4	int:CEP19
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2B MECP2	9.22e-05	11	24	2	1025
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	RBM10 GPATCH1	3.84e-04	22	24	2	579
GeneFamily	X-linked mental retardation\|Angiotensin receptors	ATRX MECP2	2.23e-03	53	24	2	103
GeneFamily	Sterile alpha motif domain containing	SAMD9L BICC1	6.03e-03	88	24	2	760
GeneFamily	PHD finger proteins	BAZ2B PHF3	6.30e-03	90	24	2	88
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	BBX PER2 ATRX RRP1B BAZ2B MECP2 PHF3 ARID5B	4.00e-08	300	45	8	M8702
Coexpression	TABULA_MURIS_SENIS_KIDNEY_KIDNEY_COLLECTING_DUCT_PRINCIPAL_CELL_AGEING	SLTM SAMD9L BBX RESF1 ATRX HBEGF BICC1 CXADR	3.22e-07	394	45	8	MM3724
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	EVI5 TMEM131 BBX ATRX BAZ2B MECP2 PHF3 ARID5B	1.14e-06	466	45	8	M13522
Coexpression	SHEN_SMARCA2_TARGETS_UP	SLTM TMEM131 ATRX BAZ2B MECP2 PHF3 ZC3H15	7.95e-06	429	45	7	M29
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	EVI5 TMEM131 BBX ATRX BAZ2B MECP2 ATP2B4 PHF3 ARID5B	1.25e-05	856	45	9	M4500
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	EVI5 IRF2 PPIG TMEM131 GNL3L ATRX RRP1B ZC3H15 RBM10 MRPL48	3.19e-05	1215	45	10	M41122
Coexpression	HOSHIDA_LIVER_CANCER_SUBCLASS_S2	BRD3 RRP1B PHF3 CXADR	4.56e-05	115	45	4	M7995
Coexpression	LU_EZH2_TARGETS_DN	RRP1B ATP2B4 HBEGF N4BP2 GFPT1 CXADR	5.99e-05	400	45	6	M2140
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G6	BBX RRP1B MECP2 PHF3	1.12e-04	145	45	4	M1810
Coexpression	STK33_SKM_UP	EVI5 RESF1 ATRX HBEGF ARID5B	1.14e-04	279	45	5	M2857
Coexpression	RUIZ_TNC_TARGETS_UP	RESF1 BAZ2B ATP2B4 ARID5B	1.49e-04	156	45	4	M988
Coexpression	GSE7348_UNSTIM_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_DN	SAMD9L BBX ZC3H15 ARID5B	1.68e-04	161	45	4	M6848
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	PPIG BBX ATRX BAZ2B PHF3 CFAP97 ARID5B	1.17e-09	199	45	7	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLTM PPIG RESF1 ATRX HBEGF ARID5B	3.50e-08	188	45	6	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	PPIG TMEM131 GNL3L RESF1 ATRX	1.22e-06	186	45	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L PER2 ATRX HBEGF ARID5B	1.50e-06	194	45	5	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	BBX ATRX PHF3 CFAP97 ARID5B	1.70e-06	199	45	5	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	EVI5 PPIG ATRX ZC3H15 CFAP97	1.70e-06	199	45	5	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	CHD6 BBX BAZ2B CFAP97	3.61e-05	185	45	4	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L ATRX BAZ2B PHF3	4.09e-05	191	45	4	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L ATRX BAZ2B PHF3	4.09e-05	191	45	4	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L ATRX BAZ2B PHF3	4.09e-05	191	45	4	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-suprabasal_differentiating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX RRP1B BAZ2B KNOP1	4.26e-05	193	45	4	49f4fbec91acda4727703e0e359ed780eefb8a22
ToppCell	CV-Severe-6\|Severe / Virus stimulation, Condition and Cluster	IRF2 SAMD9L ATP2B4 ARID5B	4.35e-05	194	45	4	d33be6ed1de907aeea0c2dce09796556b8efdd4e
ToppCell	CV-Severe-6\|CV / Virus stimulation, Condition and Cluster	IRF2 SAMD9L RESF1 ATP2B4	4.44e-05	195	45	4	69095c6ce2a7e763afa543c10d5710e0c3dda769
ToppCell	(1)_T_cells-(1)_T_CD4_naive\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	RESF1 ATRX PHF3 N4BP2	4.44e-05	195	45	4	d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	SLTM PPIG ATRX KNOP1	4.62e-05	197	45	4	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SAMD9L RESF1 ATRX PHF3	4.71e-05	198	45	4	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	SLTM EVI5 PPIG ATRX	4.71e-05	198	45	4	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	SAMD9L RESF1 ATRX ARID5B	4.80e-05	199	45	4	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	PPIG ATRX BAZ2B PHF3	4.80e-05	199	45	4	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	RESF1 STXBP1 ATRX BAZ2B	4.89e-05	200	45	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9L RESF1 ATRX ATP2B4	4.89e-05	200	45	4	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SAMD9L RESF1 ATRX PHF3	4.89e-05	200	45	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	blood copper measurement	IRF2 ATP2B4 RPH3A	5.39e-05	50	43	3	EFO_0007578
Disease	intraocular pressure measurement	BRD3 TRDN FAM186A BICC1 ARID5B	8.40e-04	509	43	5	EFO_0004695
Disease	neutrophil percentage of leukocytes	TMEM131 BRD3 BAZ2B TCF7L1 ARID5B	1.87e-03	610	43	5	EFO_0007990
Disease	blood phosphate measurement	TMEM131 BBX TCF7L1	2.09e-03	174	43	3	EFO_0010972

Protein segments in the cluster

Peptide	Gene	Start	Entry
DKKKVLVKVHPEGKF	PSMC5	81	P62195
HKVKAEEEKKAKVAP	BRD3	511	Q15059
KAAKKGKEKHEPDVS	CFAP97	306	Q9P2B7
KYKHKKEKPNVPEKG	BBX	751	Q8WY36
KLHVKGKKTNESKKG	BAZ2B	1991	Q9UIF8
PEFHKLKAKLIKKKG	CFAP418	161	Q96NL8
KKDPHIKVSGKKEDV	BICC1	101	Q9H694
EKKKKGKKQGVPENR	ATP2B4	296	P23634
APSKEGKEKKEKHKT	RBM10	631	P98175
KEIKEAIKKHIGQAK	OR6K2	296	Q8NGY2
KGKKPKTEKEDKVKH	IRF2	121	P14316
KPFQKEKHGKVAHKQ	FRA10AC1	36	Q70Z53
LEVPQKEKHKKNKDK	GPATCH1	846	Q9BRR8
KHKGKQKNKKPEKSS	GPATCH1	881	Q9BRR8
KELKVHLPADKKAKG	PER2	116	O15055
KKEKQVKELVHKGIP	EVI5	151	O60447
HKVDLGLPEKKKKKK	KNOP1	6	Q1ED39
PNRKNEKEKKVKDHK	PPIG	416	Q13427
KKTKPKEHKEVKGRN	ATRX	1356	P46100
VPHDKIGKIFKKCKK	GRHL1	566	Q9NZI5
PKKAKEHKEPKQKDG	CHD6	136	Q8TD26
KVKKAPGVANKKIHL	CXADR	121	P78310
DTAEPQKGKIKGKKH	FAM186A	596	A6NE01
PNKEEHGKRKKKGKG	HBEGF	86	Q99075
SKKKVHKPKKDGETK	FAM111B	301	Q6SJ93
VKKDKKEEKEGKHEP	MECP2	31	P51608
PDMGKKAKHKTQIKK	RPH3A	596	Q9Y2J0
GKHKKKGNKLLEKTN	RRP1B	361	Q14684
KKKGKVKALDEEVHK	GFPT1	61	Q06210
EVKKKKHDKQEQKGS	RESF1	1386	Q9HCM1
ANAKHKKKGKLKPEQ	SAMD9L	146	Q8IVG5
HKNKKPGEGSKGHKK	GNL3L	6	Q9NVN8
NKKPTKGKGKKHEAD	SLTM	76	Q9NWH9
HLIKAEEPKKKKGKV	MRPL48	61	Q96GC5
HDVIKKVKKKGEWKV	STXBP1	16	P61764
HEIPKSKKEKENAPK	ARID5B	446	Q14865
KSPVTVKKEEEKKPH	TCF7L1	331	Q9HCS4
VKKEEEKKPHVKKPL	TCF7L1	336	Q9HCS4
KQEEKEKKGKGKPQE	TMEM131	1396	Q92545
EGIKFKKQKEKKHDI	PPAT	471	Q06203
SKPGTHEKQEMKKKK	PHF3	891	Q92576
MKKKKVEKGVLNVHP	PHF3	901	Q92576
NQIKLKLHGGKKKVK	STAB2	471	Q8WWQ8
QGKSHGKKQKKPEVD	SMKR1	11	H3BMG3
KVTHKEKEKGKEKVR	TRDN	161	Q13061
QPKGKKQEKKEKHVE	TRDN	391	Q13061
KQEKKEKHVEPAKSP	TRDN	396	Q13061
VVNKKHGEAEKKKPK	ZC3H15	161	Q8WU90
KHKKKGKEAKVINEE	WDR87	1191	Q6ZQQ6
HTGQKSKEKKPKKLK	N4BP2	1586	Q86UW6