Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	synaptic vesicle uncoating	SH3GL1 SH3GL2 SH3GL3	5.57e-07	7	53	3	GO:0016191
GeneOntologyBiologicalProcess	clathrin coat disassembly	SH3GL1 SH3GL2 SH3GL3	8.89e-07	8	53	3	GO:0072318
GeneOntologyBiologicalProcess	vesicle uncoating	SH3GL1 SH3GL2 SH3GL3	1.33e-06	9	53	3	GO:0072319
GeneOntologyCellularComponent	transcription factor TFIIF complex	GTF2F1 GTF2F2	6.31e-06	2	53	2	GO:0005674
Domain	BAR	SH3GL1 SH3GL2 SH3GL3 DNMBP	8.32e-08	15	54	4	PF03114
Domain	BAR	SH3GL1 SH3GL2 SH3GL3 DNMBP	8.32e-08	15	54	4	SM00721
Domain	BAR_dom	SH3GL1 SH3GL2 SH3GL3 DNMBP	1.11e-07	16	54	4	IPR004148
Domain	BAR	SH3GL1 SH3GL2 SH3GL3 DNMBP	2.34e-07	19	54	4	PS51021
Domain	SH3_1	MYO1E SH3GL1 SH3GL2 SH3GL3 ARHGEF9 ARHGEF4 DNMBP	4.43e-07	164	54	7	PF00018
Domain	-	SH3GL1 SH3GL2 SH3GL3 DNMBP	1.62e-06	30	54	4	1.20.1270.60
Domain	AH/BAR-dom	SH3GL1 SH3GL2 SH3GL3 DNMBP	1.62e-06	30	54	4	IPR027267
Domain	SH3	MYO1E SH3GL1 SH3GL2 SH3GL3 ARHGEF9 ARHGEF4 DNMBP	2.80e-06	216	54	7	PS50002
Domain	SH3	MYO1E SH3GL1 SH3GL2 SH3GL3 ARHGEF9 ARHGEF4 DNMBP	2.80e-06	216	54	7	SM00326
Domain	SH3_domain	MYO1E SH3GL1 SH3GL2 SH3GL3 ARHGEF9 ARHGEF4 DNMBP	3.17e-06	220	54	7	IPR001452
Domain	TFIIF_interaction	GTF2F1 GTF2F2	8.21e-06	2	54	2	IPR011039
Domain	Spectrin_alpha_SH3	SH3GL1 SH3GL2 SH3GL3	1.01e-05	15	54	3	IPR013315
Domain	Maf_TF_N	MAFA MAF	4.90e-05	4	54	2	IPR013592
Domain	Maf_N	MAFA MAF	4.90e-05	4	54	2	PF08383
Domain	SH3_2	SH3GL2 SH3GL3 ARHGEF9 DNMBP	1.11e-04	86	54	4	IPR011511
Domain	SH3_2	SH3GL2 SH3GL3 ARHGEF9 DNMBP	1.11e-04	86	54	4	PF07653
Domain	Transciption_factor_Maf_fam	MAFA MAF	1.71e-04	7	54	2	IPR024874
Domain	bZIP_Maf	MAFA MAF	6.27e-04	13	54	2	IPR004826
Domain	bZIP_Maf	MAFA MAF	6.27e-04	13	54	2	PF03131
Domain	DH_1	ARHGEF9 ARHGEF4 DNMBP	8.03e-04	63	54	3	PS00741
Domain	-	MAFA MAF	9.59e-04	16	54	2	1.10.880.10
Domain	RhoGEF	ARHGEF9 ARHGEF4 DNMBP	1.00e-03	68	54	3	SM00325
Domain	DH_2	ARHGEF9 ARHGEF4 DNMBP	1.09e-03	70	54	3	PS50010
Domain	RhoGEF	ARHGEF9 ARHGEF4 DNMBP	1.09e-03	70	54	3	PF00621
Domain	DH-domain	ARHGEF9 ARHGEF4 DNMBP	1.14e-03	71	54	3	IPR000219
Domain	-	ARHGEF9 ARHGEF4 DNMBP	1.14e-03	71	54	3	1.20.900.10
Domain	TF_DNA-bd	MAFA MAF	5.12e-03	37	54	2	IPR008917
Domain	GDS_CDC24_CS	ARHGEF4 DNMBP	5.68e-03	39	54	2	IPR001331
Domain	TPR_2	TTC9B TTC14	9.20e-03	50	54	2	PF07719
Domain	TPR_2	TTC9B TTC14	9.20e-03	50	54	2	IPR013105
Domain	BRLZ	MAFA MAF	9.92e-03	52	54	2	SM00338
Domain	BZIP	MAFA MAF	1.03e-02	53	54	2	PS50217
Domain	BZIP_BASIC	MAFA MAF	1.03e-02	53	54	2	PS00036
Domain	bZIP	MAFA MAF	1.07e-02	54	54	2	IPR004827
Pathway	REACTOME_INLB_MEDIATED_ENTRY_OF_LISTERIA_MONOCYTOGENES_INTO_HOST_CELL	SH3GL1 SH3GL2 SH3GL3	6.81e-06	15	36	3	M27774
Pathway	REACTOME_LISTERIA_MONOCYTOGENES_ENTRY_INTO_HOST_CELLS	SH3GL1 SH3GL2 SH3GL3	1.69e-05	20	36	3	M27780
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY	SH3GL1 SH3GL2 SH3GL3	1.97e-05	21	36	3	M27645
Pathway	REACTOME_NEGATIVE_REGULATION_OF_MET_ACTIVITY	SH3GL1 SH3GL2 SH3GL3	1.97e-05	21	36	3	MM15347
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGAP1 ARHGEF9 ARHGEF4 DNMBP FAM13B	4.31e-05	155	36	5	M41808
Pathway	PID_CDC42_REG_PATHWAY	ARHGAP1 ARHGEF9 DNMBP	5.92e-05	30	36	3	M83
Pathway	REACTOME_EGFR_DOWNREGULATION	SH3GL1 SH3GL2 SH3GL3	6.55e-05	31	36	3	MM14705
Pathway	REACTOME_EGFR_DOWNREGULATION	SH3GL1 SH3GL2 SH3GL3	6.55e-05	31	36	3	M16597
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGAP1 ARHGEF9 DNMBP FAM13B	9.27e-05	94	36	4	MM15598
Pathway	REACTOME_SIGNALING_BY_EGFR	SH3GL1 SH3GL2 SH3GL3	2.60e-04	49	36	3	MM14695
Pathway	REACTOME_SIGNALING_BY_EGFR	SH3GL1 SH3GL2 SH3GL3	3.28e-04	53	36	3	M27039
Pathway	REACTOME_SIGNALING_BY_MET	SH3GL1 SH3GL2 SH3GL3	6.55e-04	67	36	3	MM15345
Pathway	REACTOME_BACTERIAL_INFECTION_PATHWAYS	SH3GL1 SH3GL2 SH3GL3	7.76e-04	71	36	3	M48033
Pathway	REACTOME_FGFR2_ALTERNATIVE_SPLICING	GTF2F1 GTF2F2	9.46e-04	18	36	2	MM15334
Pathway	REACTOME_SIGNALING_BY_FGFR2_IIIA_TM	GTF2F1 GTF2F2	1.06e-03	19	36	2	M27739
Pathway	REACTOME_SIGNALING_BY_MET	SH3GL1 SH3GL2 SH3GL3	1.06e-03	79	36	3	M27643
Pathway	REACTOME_ABORTIVE_ELONGATION_OF_HIV_1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT	GTF2F1 GTF2F2	1.55e-03	23	36	2	M3630
Pathway	REACTOME_FGFR2_ALTERNATIVE_SPLICING	GTF2F1 GTF2F2	2.14e-03	27	36	2	M27632
Pathway	REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS	SH3GL1 SH3GL2 SH3GL3	2.21e-03	102	36	3	MM15498
Pathway	REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS	SH3GL1 SH3GL2 SH3GL3	2.40e-03	105	36	3	M27752
Pathway	REACTOME_MRNA_CAPPING	GTF2F1 GTF2F2	2.47e-03	29	36	2	M745
Pathway	REACTOME_MRNA_CAPPING	GTF2F1 GTF2F2	2.47e-03	29	36	2	MM15409
Pubmed	LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.	SH3GL1 SH3GL2 SH3GL3	1.41e-08	4	54	3	22998870
Pubmed	Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.	SH3GL1 SH3GL2 SH3GL3	1.41e-08	4	54	3	32152276
Pubmed	EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.	SH3GL1 SH3GL2 SH3GL3	1.41e-08	4	54	3	9122235
Pubmed	Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.	SH3GL1 SH3GL2 SH3GL3	1.41e-08	4	54	3	10816441
Pubmed	Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis.	SH3GL1 SH3GL2 SH3GL3	1.41e-08	4	54	3	29953872
Pubmed	Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System.	SH3GL1 SH3GL2 SH3GL3	3.53e-08	5	54	3	27720640
Pubmed	Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.	SH3GL1 SH3GL2 SH3GL3	3.53e-08	5	54	3	12034747
Pubmed	Upregulation of Parkin in endophilin mutant mice.	SH3GL1 SH3GL2 SH3GL3	3.53e-08	5	54	3	25471590
Pubmed	The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.	SH3GL1 SH3GL2 SH3GL3	7.05e-08	6	54	3	10764144
Pubmed	Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries.	SH3GL1 SH3GL2 SH3GL3	7.05e-08	6	54	3	9238627
Pubmed	A novel SH3-containing human gene family preferentially expressed in the central nervous system.	SH3GL1 SH3GL2 SH3GL3	7.05e-08	6	54	3	9169142
Pubmed	Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.	SH3GL1 SH3GL2 SH3GL3	7.05e-08	6	54	3	23187129
Pubmed	Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.	NRAP SH3GL1 SH3GL2 SH3GL3	1.03e-07	28	54	4	10087302
Pubmed	Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap.	SH3GL1 SH3GL2 SH3GL3	1.23e-07	7	54	3	25771685
Pubmed	The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.	SH3GL1 SH3GL2 SH3GL3	1.23e-07	7	54	3	10542231
Pubmed	Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin.	SH3GL1 SH3GL2 SH3GL3	1.23e-07	7	54	3	9341169
Pubmed	Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.	SH3GL1 SH3GL2 SH3GL3	1.97e-07	8	54	3	16115810
Pubmed	SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination.	SH3GL1 SH3GL2 SH3GL3	1.97e-07	8	54	3	20064468
Pubmed	Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission.	SH3GL1 SH3GL2 SH3GL3	1.97e-07	8	54	3	22099461
Pubmed	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.	SH3GL1 SH3GL2 SH3GL3	5.79e-07	11	54	3	11894096
Pubmed	Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1.	SH3GL1 SH3GL2 SH3GL3	5.79e-07	11	54	3	12456676
Pubmed	Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.	SH3GL1 SH3GL2 SH3GL3	1.59e-06	15	54	3	9630982
Pubmed	Domain structure of a human general transcription initiation factor, TFIIF.	GTF2F1 GTF2F2	2.37e-06	2	54	2	8441635
Pubmed	Importance of codon preference for production of human RAP74 and reconstitution of the RAP30/74 complex.	GTF2F1 GTF2F2	2.37e-06	2	54	2	7827505
Pubmed	Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.	MAFA MAF	2.37e-06	2	54	2	12011435
Pubmed	Roles for both the RAP30 and RAP74 subunits of transcription factor IIF in transcription initiation and elongation by RNA polymerase II.	GTF2F1 GTF2F2	2.37e-06	2	54	2	7929273
Pubmed	TFIIF facilitates dissociation of RNA polymerase II from noncoding RNAs that lack a repression domain.	GTF2F1 GTF2F2	2.37e-06	2	54	2	19841064
Pubmed	Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.	MAFA MAF	2.37e-06	2	54	2	25763640
Pubmed	Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution.	GTF2F1 GTF2F2	2.37e-06	2	54	2	11183778
Pubmed	Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.	SH3GL2 SH3GL3	7.09e-06	3	54	2	15919751
Pubmed	Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.	MYO1E SH3GL2	7.09e-06	3	54	2	17257598
Pubmed	NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase.	GTF2F1 GTF2F2	7.09e-06	3	54	2	19215094
Pubmed	Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor.	GTF2F1 GTF2F2	7.09e-06	3	54	2	7854423
Pubmed	Transcription factors IIF and IIS and nucleoside triphosphate substrates as dynamic probes of the human RNA polymerase II mechanism.	GTF2F1 GTF2F2	7.09e-06	3	54	2	15351637
Pubmed	RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.	GTF2F1 GTF2F2	7.09e-06	3	54	2	8662660
Pubmed	The YEATS family member GAS41 interacts with the general transcription factor TFIIF.	GTF2F1 GTF2F2	7.09e-06	3	54	2	20618999
Pubmed	Transcription factor TFIIF is not required for initiation by RNA polymerase II, but it is essential to stabilize transcription factor TFIIB in early elongation complexes.	GTF2F1 GTF2F2	7.09e-06	3	54	2	21896726
Pubmed	Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership.	SH3GL1 SH3GL2	7.09e-06	3	54	2	22167186
Pubmed	Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.	SH3GL2 SH3GL3	7.09e-06	3	54	2	10535961
Pubmed	Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.	GTF2F1 GTF2F2	7.09e-06	3	54	2	16878124
Pubmed	Structure-function analysis of Msx2-mediated transcriptional suppression.	GTF2F1 GTF2F2	7.09e-06	3	54	2	9265625
Pubmed	The transcription factor c-Maf controls touch receptor development and function.	CRYGS MAFA MAF	1.01e-05	27	54	3	22345400
Pubmed	Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis.	MAFA MAF	1.42e-05	4	54	2	28933784
Pubmed	Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP).	GTF2F1 GTF2F2	1.42e-05	4	54	2	12737519
Pubmed	Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk.	FAM227B MAF	1.42e-05	4	54	2	21565293
Pubmed	Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF.	GTF2F1 GTF2F2	1.42e-05	4	54	2	9238003
Pubmed	The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.	SH3GL2 SH3GL3	1.42e-05	4	54	2	9238017
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ARHGAP1 TBRG1 MYO1E SH3GL1 TMEM131 SEC31A DNMBP INO80E	1.52e-05	724	54	8	36232890
Pubmed	Calmodulin Promotes N-BAR Domain-Mediated Membrane Constriction and Endocytosis.	SH3GL1 SH3GL2	2.36e-05	5	54	2	27093085
Pubmed	Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit.	GTF2F1 GTF2F2	2.36e-05	5	54	2	9677423
Pubmed	Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein.	SH3GL1 SH3GL3	2.36e-05	5	54	2	14551139
Pubmed	Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.	MAFA MAF	2.36e-05	5	54	2	12917329
Pubmed	The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.	GTF2F1 GTF2F2 POLE	3.11e-05	39	54	3	9121429
Pubmed	Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors.	GTF2F1 GTF2F2	3.54e-05	6	54	2	8794892
Pubmed	Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.	SH3GL2 SH3GL3	3.54e-05	6	54	2	24076656
Pubmed	Role of large MAF transcription factors in the mouse endocrine pancreas.	MAFA MAF	3.54e-05	6	54	2	25912440
Pubmed	Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.	SH3GL1 SH3GL2	3.54e-05	6	54	2	28235806
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PHLDB3 PNPLA6 MYO1E POLE MTG2 SH3BP5L CFAP43 ARHGEF4 DNMBP	4.69e-05	1105	54	9	35748872
Pubmed	Neither MafA/L-Maf nor MafB is essential for lens development in mice.	MAFA MAF	4.94e-05	7	54	2	19624757
Pubmed	Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.	SH3GL1 SH3GL2	6.59e-05	8	54	2	11894095
Pubmed	SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements.	CLK2 SRSF9	6.59e-05	8	54	2	9671816
Pubmed	Tat-SF1 protein associates with RAP30 and human SPT5 proteins.	GTF2F1 GTF2F2	6.59e-05	8	54	2	10454543
Pubmed	Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.	SH3GL2 SH3GL3	6.59e-05	8	54	2	18602463
Pubmed	Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.	GTF2F1 GTF2F2	6.59e-05	8	54	2	8628277
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGAP1 UTP11 SH3GL1 SH3GL2 ARHGEF9 ARHGEF4 DNMBP FAM13B	7.99e-05	916	54	8	32203420
Pubmed	Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.	MAFA MAF	8.46e-05	9	54	2	22120711
Pubmed	Transcription factor IIE binds preferentially to RNA polymerase IIa and recruits TFIIH: a model for promoter clearance.	GTF2F1 GTF2F2	8.46e-05	9	54	2	7926747
Pubmed	CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.	SH3GL2 SH3GL3	8.46e-05	9	54	2	12177062
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	ARHGAP1 GTF2F2 SAMD9 NSA2 SEC31A BZW1	9.01e-05	472	54	6	38943005
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	ARHGEF9 ARHGEF4 DNMBP	9.25e-05	56	54	3	22745667
Pubmed	Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord.	MAFA MAF	1.06e-04	10	54	2	31231191
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	ARHGAP1 GTF2F2 SAMD9 PNPLA6 MYO1E NSA2 UTP11 PISD SRSF9	1.26e-04	1257	54	9	36526897
Pubmed	Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation.	GTF2F1 GTF2F2	1.29e-04	11	54	2	11113176
Pubmed	A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.	MAFA MAF	1.55e-04	12	54	2	16580660
Pubmed	Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators.	GTF2F1 GTF2F2	1.55e-04	12	54	2	9305922
Pubmed	RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits.	GTF2F1 GTF2F2	1.55e-04	12	54	2	15282305
Pubmed	Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.	SH3GL1 SH3GL2	1.83e-04	13	54	2	23146885
Pubmed	Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.	GTF2F1 GTF2F2	1.83e-04	13	54	2	25492609
Pubmed	Maximizing binary interactome mapping with a minimal number of assays.	ARHGAP1 GTF2F1 GTF2F2	2.04e-04	73	54	3	31467278
Pubmed	Two distinct origins for Leydig cell progenitors in the fetal testis.	MAFA MAF	2.13e-04	14	54	2	21255566
Pubmed	Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation.	PISD SEC31A	2.13e-04	14	54	2	34995116
Pubmed	Phosphorylation of the RAP74 subunit of TFIIF correlates with Tat-activated transcription of the HIV-1 long terminal repeat.	GTF2F1 GTF2F2	2.45e-04	15	54	2	10704353
Pubmed	Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.	GTF2F1 GTF2F2	2.80e-04	16	54	2	9409616
Pubmed	HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.	GTF2F1 GTF2F2	3.17e-04	17	54	2	1559613
Pubmed	Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation.	CRYGS MAF	3.56e-04	18	54	2	16162653
Pubmed	Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.	MAFA MAF	3.56e-04	18	54	2	31969659
Pubmed	MafB is required for islet beta cell maturation.	MAFA MAF	3.56e-04	18	54	2	17360442
Pubmed	HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention.	GTF2F1 GTF2F2	3.98e-04	19	54	2	21489275
Pubmed	Nucleolar proteome dynamics.	GTF2F1 VRK1 GTF2F2 NSA2 UTP11	4.82e-04	419	54	5	15635413
Pubmed	MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.	MAFA MAF	4.88e-04	21	54	2	29324782
Pubmed	UPF2 is a critical regulator of liver development, function and regeneration.	SRSF9 CLASRP	6.39e-04	24	54	2	20657840
Pubmed	Comprehensive proteomic analysis of the human spliceosome.	GTF2F1 GTF2F2 SRSF9	6.61e-04	109	54	3	12226669
Pubmed	Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.	GTF2F1 GTF2F2	6.94e-04	25	54	2	9790902
Pubmed	Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.	GTF2F1 GTF2F2	6.94e-04	25	54	2	9512541
Pubmed	Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.	GTF2F1 GTF2F2	6.94e-04	25	54	2	8934526
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	SH3GL1 SH3GL3 TMEM131 DNMBP	7.51e-04	263	54	4	34702444
Pubmed	The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.	MAFA MAF	8.72e-04	28	54	2	26554594
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	GTF2F1 TBRG1 NSA2 CLK2 TSN SRSF9	8.74e-04	723	54	6	34133714
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PHLDB3 GTF2F1 SPC25 TMEM131 SH3BP5L BZW1	9.39e-04	733	54	6	34672954
Pubmed	A human MAP kinase interactome.	ARHGEF9 SH3BP5L SEC31A ARHGEF4 FAM13B	9.40e-04	486	54	5	20936779
Interaction	ARHGAP8 interactions	ARHGAP1 SH3GL1 SH3GL2 SH3GL3	1.20e-06	30	54	4	int:ARHGAP8
Interaction	PRR5-ARHGAP8 interactions	SH3GL1 SH3GL2 SH3GL3	2.15e-06	10	54	3	int:PRR5-ARHGAP8
Interaction	LBH interactions	MAP9 GTF2F1 GTF2F2	3.10e-05	23	54	3	int:LBH
Interaction	PSENEN interactions	MAP9 GTF2F1 GTF2F2 UTP11	6.57e-05	81	54	4	int:PSENEN
Interaction	SH3GL1 interactions	ARHGAP1 GTF2F2 SH3GL1 SH3GL2 SH3GL3	7.69e-05	164	54	5	int:SH3GL1
Interaction	SERF2 interactions	MAP9 GTF2F1 GTF2F2 UTP11	8.69e-05	87	54	4	int:SERF2
GeneFamily	N-BAR domain containing	SH3GL1 SH3GL2 SH3GL3	1.44e-06	12	35	3	1289
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF9 ARHGEF4 DNMBP	2.80e-04	66	35	3	722
GeneFamily	General transcription factors\|Xeroderma pigmentosum complementation groups\|DNA helicases\|ERCC excision repair associated	GTF2F1 GTF2F2	1.06e-03	25	35	2	565
GeneFamily	Basic leucine zipper proteins	MAFA MAF	4.04e-03	49	35	2	506
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP1 FAM13B	4.21e-03	50	35	2	721
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLDB3 ARHGEF9 ARHGEF4	7.30e-03	206	35	3	682
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC9B TTC14	2.08e-02	115	35	2	769
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLXIPL INSRR SPC25 TTC14 SEC31A	3.77e-06	194	54	5	92b39a935e8c577eb1123d706d168fa13cf3344c
Computational	Response to DNA damage.	VRK1 GTF2F2 MYO1E CLK2 POLE	1.51e-04	187	30	5	MODULE_244
Disease	high grade glioma (implicated_via_orthology)	POLE SH3GL1 INSRR	5.77e-05	44	50	3	DOID:3070 (implicated_via_orthology)
Disease	congenital left-sided heart lesions	ANXA10 CFAP43 ARHGEF4	7.50e-05	48	50	3	EFO_0005938
Disease	fat intake measurement	MLXIPL NRAP	6.36e-04	22	50	2	EFO_0010809

Protein segments in the cluster

Peptide	Gene	Start	Entry
RKLERYGEFLKKYHK	FAM227B	116	Q96M60
RGRLKDEIIHKYLYE	CFAP43	571	Q8NDM7
DLLTIRKRYKERYGK	ANXA10	281	Q9UJ72
RKRYKERYGKSLFHD	ANXA10	286	Q9UJ72
KLIRRYKYLEKGFED	BZW1	116	Q7L1Q6
EKARPYYEARRLAKE	SH3BP5L	111	Q7L8J4
RKTRKQKYFYRGRLD	CLK2	406	P49760
RKLDERNRLLGEYKK	DIXDC1	411	Q155Q3
IDYRKRELPAAGKLY	AFG1L	281	Q8WV93
CKKDLLRRDVLYYKG	ARHGEF4	531	Q9NR80
EYKRRKDLVLKYRKG	DNMBP	966	Q6XZF7
KKDLIRRDILYYKGR	ARHGEF9	351	O43307
RRDILYYKGRIDMDK	ARHGEF9	356	O43307
YRLDYHEKKRKKESR	NSA2	16	O95478
RRLAYYADKEETKLK	PHLDB3	561	Q6NSJ2
DYFRKFRRRKEKGLL	CACNA1F	1591	O60840
YRFRKRDKVLFYGRK	PNPLA6	96	Q8IY17
GRLAKERDLYKEKYE	MAFA	301	Q8NHW3
ERDLYKEKYEKLAGR	MAFA	306	Q8NHW3
RLVRERDAYKEKYEK	MAF	336	O75444
YLKEKNRKEREYERA	MAP9	526	Q49MG5
KYKEDYERSRGKLIG	NRAP	821	Q86VF7
LEEYREYKKIKAKLR	FAM13B	886	Q9NYF5
DFGLARRYKPREKLK	MYLK3	656	Q32MK0
AKYEKRRLADYCRKA	POLE	716	Q07864
DGEVDYKKKYRNLKR	INO80E	6	Q8NBZ0
RGRQYLLDKKEYRKP	CRYGS	146	P22914
KKRYGRFQAAKELRE	DIPK2A	406	Q8NDZ4
RKLQEEYYEEKRRKE	BCL9L	521	Q86UU0
ILKYEIKYRRLGEEA	INSRR	846	P14616
KKREFYRDKKYEEVR	P2RX5	341	Q93086
FNRKLREEARRKKYG	GTF2F1	71	P35269
YNIEYERKKKEDGKR	GTF2F2	161	P13984
ADDYRKKQEYLKALR	UTP11	41	Q9Y3A2
REKDLEDLFYKYGRI	SRSF9	26	Q13242
LEGRRLDYDYKKKRV	SH3GL3	161	Q99963
RLRKKYREVGDFDKI	BMT2	46	Q1RMZ1
EVKERLYPKSKRRYD	SAMD9	1176	Q5K651
RDAYREFDRKYKKNI	ARHGAP1	141	Q07960
KKLKRYFVDYRRVLV	MTG2	66	Q9H4K7
DERERREKKLYFGYS	PXYLP1	331	Q8TE99
IYYKKRLRKPSREDD	MLXIPL	186	Q9NP71
DLYKDRLGLEIRKIY	SPC25	136	Q9HBM1
KRAERRREYYEKIKK	CLASRP	21	Q8N2M8
LEGRRLDFDYKKKRQ	SH3GL1	161	Q99961
EDCGKKLVYRSYRKD	ZNF223	431	Q9UK11
LEGRRLDFDYKKKRQ	SH3GL2	161	Q99962
NFTKKRKRKYELRYR	SYCP2L	711	Q5T4T6
RQYEKYRERELEKLG	PISD	81	Q9UG56
RFYYKRLRGNKEDLE	TMEM131	716	Q92545
IYGYRRFEKDIEGRK	TTC14	641	Q96N46
KDPKYVRDSKIRYRE	VRK1	266	Q99986
TRYEKREYGNLELKK	ZNF90	101	Q03938
RGKYLELLGYRKEDL	SEC31A	486	O94979
YREKKFREAIGKYHR	TTC9B	76	Q8N6N2
NEKYRLKYLRLRKAA	TBRG1	31	Q3YBR2
LRKRYDGLKYDVKKV	TSN	191	Q15631
TKYDRRFKGVKRDLL	MYO1E	771	Q12965