Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	adult behavior	CDH23 BBS4 DBH GRIN2D NRXN3 NRXN1 ATXN1 CNTNAP2 KCNMA1	8.77e-06	203	137	9	GO:0030534
GeneOntologyBiologicalProcess	social behavior	BBS4 NRXN3 NRXN1 ATXN1 CNTNAP2 ANKRD11	9.84e-06	74	137	6	GO:0035176
GeneOntologyBiologicalProcess	biological process involved in intraspecies interaction between organisms	BBS4 NRXN3 NRXN1 ATXN1 CNTNAP2 ANKRD11	1.15e-05	76	137	6	GO:0051703
GeneOntologyBiologicalProcess	behavior	CACNA1E CAPN2 APBA2 CDH23 BBS4 DBH GRIN2D ADNP ADORA2A NRXN3 NRXN1 ATXN1 CNTNAP2 KCNMA1 ANKRD11 DMRTA1 CTNND2	8.84e-05	891	137	17	GO:0007610
GeneOntologyBiologicalProcess	response to abiotic stimulus	CACNA1E ERCC6 RPAIN CAPN2 CAPN3 BAG3 MAP3K20 DBH GRIN2D STAC NEDD4 NRXN1 ATXN1 GUCY2F UCP2 SNAI2 CNTNAP2 KCNMA1 UCN3 ADAM17 NIPBL ABCG5	9.06e-05	1361	137	22	GO:0009628
GeneOntologyBiologicalProcess	locomotory behavior	CACNA1E APBA2 CDH23 DBH GRIN2D ADORA2A ATXN1 CNTNAP2 KCNMA1	1.21e-04	284	137	9	GO:0007626
GeneOntologyBiologicalProcess	cognition	CACNA1E BBS4 DBH ADNP NRXN3 NRXN1 ATXN1 CNTNAP2 ANKRD11 CTNND2 NIPBL	1.24e-04	423	137	11	GO:0050890
GeneOntologyBiologicalProcess	octopamine metabolic process	DBH MOXD1	1.31e-04	3	137	2	GO:0046333
GeneOntologyBiologicalProcess	octopamine biosynthetic process	DBH MOXD1	1.31e-04	3	137	2	GO:0006589
GeneOntologyBiologicalProcess	neuromuscular process	NKX6-2 CDH23 GRIN2D STAC ADORA2A NRXN1 CNTNAP2 KCNMA1	1.32e-04	225	137	8	GO:0050905
GeneOntologyBiologicalProcess	response to radiation	CACNA1E ERCC6 RPAIN MAP3K20 DBH NEDD4 ATXN1 GUCY2F SNAI2 CNTNAP2 NIPBL ABCG5	1.37e-04	503	137	12	GO:0009314
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	BOC HECW1 FAT3 CDH23 SRCIN1 ADNP EDN3 NEDD4 NRXN3 HMCN2 NRXN1 CAPRIN2 CNTNAP2 ADAM17 CTNND2	1.37e-04	748	137	15	GO:0048667
GeneOntologyBiologicalProcess	startle response	GRIN2D ADORA2A NRXN1 CNTNAP2	1.56e-04	41	137	4	GO:0001964
GeneOntologyCellularComponent	presynaptic active zone membrane	GRIN2D NRXN3 NRXN1 CNTNAP2 KCNMA1	1.67e-04	78	138	5	GO:0048787
GeneOntologyCellularComponent	calpain complex	CAPN1 CAPN2	2.57e-04	4	138	2	GO:0110158
GeneOntologyCellularComponent	presynaptic active zone	GRIN2D ADORA2A NRXN3 NRXN1 CNTNAP2 KCNMA1	3.51e-04	141	138	6	GO:0048786
GeneOntologyCellularComponent	presynaptic membrane	CACNA1E GRIN2D ZNRF2 ADORA2A NRXN3 NRXN1 CNTNAP2 KCNMA1	5.17e-04	277	138	8	GO:0042734
Domain	LAM_G_DOMAIN	CNTNAP3B FAT3 NRXN3 NRXN1 CNTNAP2	7.87e-06	38	136	5	PS50025
Domain	Laminin_G_2	CNTNAP3B FAT3 NRXN3 NRXN1 CNTNAP2	1.02e-05	40	136	5	PF02210
Domain	LamG	CNTNAP3B FAT3 NRXN3 NRXN1 CNTNAP2	1.64e-05	44	136	5	SM00282
Domain	DBH-rel	DBH MOXD1	5.26e-05	2	136	2	IPR000945
Domain	Laminin_G	CNTNAP3B FAT3 NRXN3 NRXN1 CNTNAP2	6.39e-05	58	136	5	IPR001791
Domain	calpain_III	CAPN1 CAPN2 CAPN3	7.92e-05	12	136	3	SM00720
Domain	C2_III	CAPN1 CAPN2 CAPN3	7.92e-05	12	136	3	IPR033883
Domain	Calpain_III	CAPN1 CAPN2 CAPN3	7.92e-05	12	136	3	IPR022683
Domain	Calpain_III	CAPN1 CAPN2 CAPN3	1.02e-04	13	136	3	PF01067
Domain	Calpain_domain_III	CAPN1 CAPN2 CAPN3	1.02e-04	13	136	3	IPR022682
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT3 MMRN1 NRXN3 HMCN2 NRXN1 TLL2	1.25e-04	106	136	6	IPR000152
Domain	Calpain_cysteine_protease	CAPN1 CAPN2 CAPN3	1.30e-04	14	136	3	IPR022684
Domain	Neurexin-like	NRXN3 NRXN1 CNTNAP2	1.30e-04	14	136	3	IPR003585
Domain	4.1m	NRXN3 NRXN1 CNTNAP2	1.30e-04	14	136	3	SM00294
Domain	Cu2_monoox_C	DBH MOXD1	1.57e-04	3	136	2	IPR024548
Domain	Cu2_ascorb_mOase_N	DBH MOXD1	1.57e-04	3	136	2	IPR000323
Domain	Cu2_monoox_C	DBH MOXD1	1.57e-04	3	136	2	PF03712
Domain	CU2_MONOOXYGENASE_1	DBH MOXD1	1.57e-04	3	136	2	PS00084
Domain	CU2_MONOOXYGENASE_2	DBH MOXD1	1.57e-04	3	136	2	PS00085
Domain	PHM/PNGase_F_dom	DBH MOXD1	1.57e-04	3	136	2	IPR008977
Domain	Cu2_monooxygen	DBH MOXD1	1.57e-04	3	136	2	PF01082
Domain	Cu2_ascorb_mOase-like_C	DBH MOXD1	1.57e-04	3	136	2	IPR014784
Domain	-	DBH MOXD1	1.57e-04	3	136	2	2.60.120.230
Domain	-	DBH MOXD1	1.57e-04	3	136	2	2.60.120.310
Domain	Peptidase_C2	CAPN1 CAPN2 CAPN3	1.61e-04	15	136	3	PF00648
Domain	CysPc	CAPN1 CAPN2 CAPN3	1.61e-04	15	136	3	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN1 CAPN2 CAPN3	1.61e-04	15	136	3	IPR001300
Domain	CALPAIN_CAT	CAPN1 CAPN2 CAPN3	1.61e-04	15	136	3	PS50203
Domain	DOMON	DBH MOXD1	3.13e-04	4	136	2	PS50836
Domain	MADS_MEF2-like	MEF2B MEF2D	3.13e-04	4	136	2	IPR033896
Domain	DOMON_domain	DBH MOXD1	3.13e-04	4	136	2	IPR005018
Domain	DoH	DBH MOXD1	3.13e-04	4	136	2	SM00664
Domain	DOMON	DBH MOXD1	3.13e-04	4	136	2	PF03351
Domain	EGF_3	CNTNAP3B FAT3 MMRN1 NRXN3 HMCN2 NRXN1 TLL2 CNTNAP2	3.30e-04	235	136	8	PS50026
Domain	WW	HECW1 BAG3 NEDD4 PLEKHA7	3.76e-04	47	136	4	PF00397
Domain	WW	HECW1 BAG3 NEDD4 PLEKHA7	4.08e-04	48	136	4	SM00456
Domain	EGF-like_dom	CNTNAP3B FAT3 MMRN1 NRXN3 HMCN2 NRXN1 TLL2 CNTNAP2	4.84e-04	249	136	8	IPR000742
Domain	WW_DOMAIN_1	HECW1 BAG3 NEDD4 PLEKHA7	5.16e-04	51	136	4	PS01159
Domain	WW_DOMAIN_2	HECW1 BAG3 NEDD4 PLEKHA7	5.16e-04	51	136	4	PS50020
Domain	WW_dom	HECW1 BAG3 NEDD4 PLEKHA7	5.55e-04	52	136	4	IPR001202
Domain	EGF_1	CNTNAP3B FAT3 MMRN1 NRXN3 HMCN2 NRXN1 TLL2 CNTNAP2	5.67e-04	255	136	8	PS00022
Domain	EGF-like_CS	FAT3 MMRN1 NRXN3 HMCN2 NRXN1 TLL2 CNTNAP2 ADAM17	6.60e-04	261	136	8	IPR013032
Domain	EGF_2	CNTNAP3B FAT3 MMRN1 NRXN3 HMCN2 NRXN1 TLL2 CNTNAP2	7.29e-04	265	136	8	PS01186
Domain	MADS_BOX_1	MEF2B MEF2D	7.75e-04	6	136	2	PS00350
Domain	MADS	MEF2B MEF2D	7.75e-04	6	136	2	SM00432
Domain	SRF-TF	MEF2B MEF2D	7.75e-04	6	136	2	PF00319
Domain	MADS_BOX_2	MEF2B MEF2D	7.75e-04	6	136	2	PS50066
Domain	THIOL_PROTEASE_CYS	CAPN1 CAPN2 CAPN3	8.69e-04	26	136	3	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN1 CAPN2 CAPN3	9.72e-04	27	136	3	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN1 CAPN2 CAPN3	9.72e-04	27	136	3	PS00639
Domain	Syndecan	NRXN3 NRXN1	1.08e-03	7	136	2	PF01034
Domain	TF_MADSbox	MEF2B MEF2D	1.08e-03	7	136	2	IPR002100
Domain	Syndecan/Neurexin_dom	NRXN3 NRXN1	1.08e-03	7	136	2	IPR027789
Domain	Pept_cys_AS	CAPN1 CAPN2 CAPN3	1.08e-03	28	136	3	IPR000169
Domain	ConA-like_dom	CNTNAP3B MID2 FAT3 MMRN1 NRXN3 NRXN1 CNTNAP2	1.13e-03	219	136	7	IPR013320
Domain	PH_dom-like	VEPH1 APBA2 WBP2NL ARHGEF17 ARHGEF10L PHLDB1 AFAP1 PLEKHG6 MCF2L PLEKHA7	1.13e-03	426	136	10	IPR011993
Domain	DH_1	ARHGEF17 ARHGEF10L PLEKHG6 MCF2L	1.15e-03	63	136	4	PS00741
Domain	Chond_GalNAc	CHPF2 B4GALNT3	1.43e-03	8	136	2	IPR008428
Domain	CHGN	CHPF2 B4GALNT3	1.43e-03	8	136	2	PF05679
Domain	RhoGEF	ARHGEF17 ARHGEF10L PLEKHG6 MCF2L	1.53e-03	68	136	4	SM00325
Domain	EGF	CNTNAP3B FAT3 MMRN1 NRXN3 NRXN1 TLL2 CNTNAP2	1.69e-03	235	136	7	SM00181
Domain	RhoGEF	ARHGEF17 ARHGEF10L PLEKHG6 MCF2L	1.70e-03	70	136	4	PF00621
Domain	DH_2	ARHGEF17 ARHGEF10L PLEKHG6 MCF2L	1.70e-03	70	136	4	PS50010
Domain	-	ARHGEF17 ARHGEF10L PLEKHG6 MCF2L	1.79e-03	71	136	4	1.20.900.10
Domain	DH-domain	ARHGEF17 ARHGEF10L PLEKHG6 MCF2L	1.79e-03	71	136	4	IPR000219
Domain	C1q_dom	MMRN1 ERFE CAPRIN2	1.92e-03	34	136	3	IPR001073
Domain	EF-hand_8	CAPN1 CAPN2 CAPN3	1.92e-03	34	136	3	PF13833
Domain	C1Q	MMRN1 ERFE CAPRIN2	1.92e-03	34	136	3	PS50871
Domain	-	VEPH1 APBA2 ARHGEF17 ARHGEF10L PHLDB1 AFAP1 PLEKHG6 MCF2L PLEKHA7	2.28e-03	391	136	9	2.30.29.30
Domain	EGF	MMRN1 NRXN3 NRXN1 TLL2 CNTNAP2	2.30e-03	126	136	5	PF00008
Domain	SH3_2	SRMS STAC SNX18 MCF2L	3.60e-03	86	136	4	PF07653
Domain	SH3_2	SRMS STAC SNX18 MCF2L	3.60e-03	86	136	4	IPR011511
Domain	PLAC	ADAMTS18 ADAMTSL4	4.52e-03	14	136	2	PF08686
Domain	-	FAT3 NRXN3 NRXN1 CNTNAP2	5.14e-03	95	136	4	2.60.120.200
Domain	-	MMRN1 ERFE CAPRIN2	5.77e-03	50	136	3	2.60.120.40
Domain	ASX_HYDROXYL	FAT3 NRXN3 HMCN2 NRXN1	6.15e-03	100	136	4	PS00010
Pathway	PID_RHOA_REG_PATHWAY	ARHGEF17 ARHGEF10L ARHGAP6 PLEKHG6 MCF2L	1.60e-05	46	98	5	M68
Pubmed	NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain.	CAPN1 CAPN2 CAPN3	6.38e-08	3	140	3	8954122
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRAF7 PSMB10 CEP192 GRIN2D AHDC1 EML3 ARHGEF10L KCNH3 NCOR2 SEPHS2 PHLDB1 KCNG1 NAPRT GLI1 ANKRD11 DTX2 MAPKBP1 MCF2L PRRT4	1.08e-07	1105	140	19	35748872
Pubmed	Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord.	CAPN1 CAPN2 CAPN3	2.55e-07	4	140	3	8738748
Pubmed	Characterization of the calcium-dependent proteolytic system in a mouse muscle cell line.	CAPN1 CAPN2 CAPN3	2.55e-07	4	140	3	11952156
Pubmed	Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.	CAPN1 CAPN2 CAPN3	2.55e-07	4	140	3	12634108
Pubmed	Four genes for the calpain family locate on four distinct human chromosomes.	CAPN1 CAPN2 CAPN3	2.55e-07	4	140	3	2209092
Pubmed	Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity.	CAPN1 CAPN2 CAPN3	6.35e-07	5	140	3	17897354
Pubmed	Calpain translocation during muscle fiber necrosis and regeneration in dystrophin-deficient mice.	CAPN1 CAPN2 CAPN3	6.35e-07	5	140	3	8806430
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	CEP192 HRNR MEF2D SMTN ERFE NCOR2 ATXN1 RAVER1	8.68e-07	184	140	8	32908313
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1E NRXN3 NRXN1	1.27e-06	6	140	3	12827191
Pubmed	Structure and physiological function of calpains.	CAPN1 CAPN2 CAPN3	2.21e-06	7	140	3	9396712
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPN1 CAPN2 CAPN3	3.52e-06	8	140	3	9473662
Pubmed	Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2.	MEF2B MEF2D NCOR2	3.52e-06	8	140	3	17158926
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	BAG3 MAP3K20 CEP192 ARHGEF17 ZNRF2 MEF2D NEDD4 CDCA2 FSIP2 PHLDB1 ATXN1 KRT77 ANKRD11 PLEKHA7	1.07e-05	861	140	14	36931259
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRAF7 ZSWIM8 ERCC6 FAT3 APBA2 GADD45GIP1 NCOR2 HMCN2 ATXN1 SCML1 CAPRIN2 DLAT CHPF2 ADAM17 PDLIM2 KAT14	1.17e-05	1116	140	16	31753913
Pubmed	Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1.	NRXN1 CNTNAP2	1.61e-05	2	140	2	21827697
Pubmed	[Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice].	CAPN1 CAPN2	1.61e-05	2	140	2	17619446
Pubmed	Involvement of calpains in Ca2+-induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers.	CAPN1 CAPN3	1.61e-05	2	140	2	19295178
Pubmed	Calpain 1 and 2 are required for RNA replication of echovirus 1.	CAPN1 CAPN2	1.61e-05	2	140	2	18032503
Pubmed	Calpain-2 participates in the process of calpain-1 inactivation.	CAPN1 CAPN2	1.61e-05	2	140	2	33078830
Pubmed	Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.	NRXN3 NRXN1	1.61e-05	2	140	2	37543682
Pubmed	Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.	NRXN3 NRXN1	1.61e-05	2	140	2	9430716
Pubmed	mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans.	CAPN1 CAPN3	1.61e-05	2	140	2	16107503
Pubmed	Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant.	CAPN1 CAPN2	1.61e-05	2	140	2	9669314
Pubmed	CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila.	NRXN1 CNTNAP2	1.61e-05	2	140	2	19896112
Pubmed	Vitamin D₃ regulation of body fat, cytokines, and calpain gene expression.	CAPN1 CAPN2	1.61e-05	2	140	2	25520983
Pubmed	Women with undiagnosed colorectal adenocarcinomas presenting with ovarian metastases: clinicopathologic features and comparison with women having known colorectal adenocarcinomas and ovarian involvement.	KRT7 MUC16	1.61e-05	2	140	2	18317225
Pubmed	Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.	CAPN1 CAPN2	1.61e-05	2	140	2	15471877
Pubmed	m-Calpain is required for preimplantation embryonic development in mice.	CAPN1 CAPN2	1.61e-05	2	140	2	16433929
Pubmed	Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study.	NRXN3 NRXN1	1.61e-05	2	140	2	19658047
Pubmed	Calpains are required for invasive and metastatic potentials of human HCC cells.	CAPN1 CAPN2	1.61e-05	2	140	2	23733271
Pubmed	Involvement of calpains in growth factor-mediated migration.	CAPN1 CAPN2	1.61e-05	2	140	2	16971167
Pubmed	Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.	CAPN1 CAPN2	1.61e-05	2	140	2	29258546
Pubmed	Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.	CAPN1 CAPN2	1.61e-05	2	140	2	28594313
Pubmed	Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.	CAPN1 CAPN2	1.61e-05	2	140	2	22335024
Pubmed	Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.	CAPN1 CAPN2	1.61e-05	2	140	2	19781581
Pubmed	Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.	CAPN1 CAPN2	1.61e-05	2	140	2	27185592
Pubmed	Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.	CAPN1 CAPN2	1.61e-05	2	140	2	22432027
Pubmed	Cerebral calpain in fatal falciparum malaria.	CAPN1 CAPN2	1.61e-05	2	140	2	17359359
Pubmed	Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.	CAPN1 CAPN2	1.61e-05	2	140	2	30177812
Pubmed	Calpains: markers of tumor aggressiveness?	CAPN1 CAPN2	1.61e-05	2	140	2	20193680
Pubmed	Different expression of calpains in the anterior vaginal wall of women with and without uterovaginal prolapse.	CAPN1 CAPN2	1.61e-05	2	140	2	14980313
Pubmed	Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury.	CAPN1 CAPN2	1.61e-05	2	140	2	22140070
Pubmed	Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes.	CAPN1 CAPN2	1.61e-05	2	140	2	19505932
Pubmed	Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression.	NCOA3 ANKRD11	1.61e-05	2	140	2	31788936
Pubmed	Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.	NRXN1 CNTNAP2	1.61e-05	2	140	2	20157312
Pubmed	Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.	APBA2 NRXN1	1.61e-05	2	140	2	17989066
Pubmed	Highly conserved structure in the promoter region of the gene for muscle-specific calpain, p94.	CAPN1 CAPN3	1.61e-05	2	140	2	8997499
Pubmed	Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.	CAPN1 CAPN2	1.61e-05	2	140	2	27622212
Pubmed	A genome-wide investigation of SNPs and CNVs in schizophrenia.	APBA2 NRXN1	1.61e-05	2	140	2	19197363
Pubmed	Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases.	CAPN1 HRNR	1.61e-05	2	140	2	27742573
Pubmed	Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.	CAPN1 CAPN2	1.61e-05	2	140	2	16723743
Pubmed	Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration.	CAPN1 CAPN2	1.61e-05	2	140	2	24285894
Pubmed	Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus.	CAPN1 CAPN2	1.61e-05	2	140	2	15302874
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	BAG3 MAP3K20 CDH23 ERFE PHLDB1 HMCN2 RBM15B ADAMTS18 CTNND2	1.68e-05	361	140	9	26167880
Pubmed	The contribution of rare and common variants in 30 genes to risk nicotine dependence.	DBH NRXN3 NRXN1	2.25e-05	14	140	3	25450229
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	MEF2D NRXN3 NRXN1	4.17e-05	17	140	3	27779093
Pubmed	Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition.	CAPN1 CAPN2	4.81e-05	3	140	2	30177525
Pubmed	Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.	NRXN3 NRXN1	4.81e-05	3	140	2	38891114
Pubmed	The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.	CAPN1 CAPN2	4.81e-05	3	140	2	28924170
Pubmed	Expression and immunolocalization of the calpain-calpastatin system in the human oocyte.	CAPN1 CAPN2	4.81e-05	3	140	2	15950654
Pubmed	Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.	CAPN1 CAPN2	4.81e-05	3	140	2	19318376
Pubmed	Profile of adipose tissue gene expression in premenopausal and postmenopausal women: site-specific differences.	KRT7 NRXN3	4.81e-05	3	140	2	21358552
Pubmed	Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.	CAPN1 CAPN2	4.81e-05	3	140	2	23977256
Pubmed	Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs.	CAPN1 CAPN2	4.81e-05	3	140	2	21839844
Pubmed	Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension.	CAPN1 CAPN2	4.81e-05	3	140	2	26974350
Pubmed	Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex.	NCOA3 ANKRD11	4.81e-05	3	140	2	24678732
Pubmed	A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling.	CAPN1 CAPN2	4.81e-05	3	140	2	21415394
Pubmed	A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.	CAPN1 CAPN2	4.81e-05	3	140	2	28334907
Pubmed	alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.	NRXN3 NRXN1	4.81e-05	3	140	2	16406382
Pubmed	The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.	CAPN1 CAPN2	4.81e-05	3	140	2	18840650
Pubmed	Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.	NRXN3 NRXN1	4.81e-05	3	140	2	31005376
Pubmed	Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.	ERCC6 CDH23	4.81e-05	3	140	2	25762674
Pubmed	Expression of typical calpains in mouse molar.	CAPN1 CAPN2	4.81e-05	3	140	2	19683220
Pubmed	Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs.	CDH23 DCHS1	4.81e-05	3	140	2	11597768
Pubmed	The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells.	CAPN1 CAPN2	4.81e-05	3	140	2	21374734
Pubmed	Utrophin is a calpain substrate in muscle cells.	CAPN1 CAPN2	4.81e-05	3	140	2	16598790
Pubmed	Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.	NRXN3 NRXN1	4.81e-05	3	140	2	26446217
Pubmed	Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D.	GRIN2D NEDD4	4.81e-05	3	140	2	23639431
Pubmed	Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.	NRXN3 NRXN1	4.81e-05	3	140	2	11944992
Pubmed	Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.	NRXN3 NRXN1	4.81e-05	3	140	2	33058888
Pubmed	Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.	NRXN3 NRXN1	4.81e-05	3	140	2	17035546
Pubmed	Neurexins: three genes and 1001 products.	NRXN3 NRXN1	4.81e-05	3	140	2	9448462
Pubmed	Deletion of α-neurexin II results in autism-related behaviors in mice.	NRXN3 NRXN1	4.81e-05	3	140	2	25423136
Pubmed	Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.	CAPN1 CAPN2	4.81e-05	3	140	2	16632474
Pubmed	TCF4, schizophrenia, and Pitt-Hopkins Syndrome.	NRXN1 CNTNAP2	4.81e-05	3	140	2	20421335
Pubmed	Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations.	CAPN1 CAPN2	4.81e-05	3	140	2	3038169
Pubmed	Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.	NRXN3 NRXN1	4.81e-05	3	140	2	34133920
Pubmed	Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice.	DBH ADORA2A	4.81e-05	3	140	2	12538862
Pubmed	The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.	NRXN3 NRXN1	4.81e-05	3	140	2	30858964
Pubmed	LOX-1 in macrophage migration in response to ox-LDL and the involvement of calpains.	CAPN1 CAPN2	4.81e-05	3	140	2	26393906
Pubmed	Sca-1+ cardiac fibroblasts promote development of heart failure.	ATXN1 IL17RA	4.81e-05	3	140	2	29953616
Pubmed	Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.	CAPN1 CAPN2	4.81e-05	3	140	2	24550490
Pubmed	Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.	NRXN3 NRXN1	4.81e-05	3	140	2	28013231
Pubmed	skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity.	CAPN1 CAPN3	4.81e-05	3	140	2	23662692
Pubmed	Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.	NRXN3 NRXN1	4.81e-05	3	140	2	31812984
Pubmed	Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.	NRXN3 NRXN1	4.81e-05	3	140	2	12036300
Pubmed	β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.	NRXN3 NRXN1	4.81e-05	3	140	2	26213384
Pubmed	Neurexin gene family variants as risk factors for autism spectrum disorder.	NRXN3 NRXN1	4.81e-05	3	140	2	29045040
Pubmed	Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors.	NCOR2 ATXN1	4.81e-05	3	140	2	15016912
GeneFamily	C2 domain containing\|Calpains	CAPN1 CAPN2 CAPN3	7.12e-05	15	100	3	975
GeneFamily	Cadherin related	FAT3 CDH23 DCHS1	1.06e-04	17	100	3	24
GeneFamily	Myocyte enhancer factor 2 proteins\|MADS box family	MEF2B MEF2D	1.80e-04	4	100	2	649
GeneFamily	Myocyte enhancer factor 2 proteins\|MADS box family	MEF2B MEF2D	3.00e-04	5	100	2	1086
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	VEPH1 PHLDB1 AFAP1 PLEKHG6 MCF2L PLEKHA7	9.97e-04	206	100	6	682
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FAT3 HRNR MOXD1 DCHS1 VSIG8 B4GALNT3 CHST2 NKAPL	5.72e-08	166	140	8	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KRT7 MUC16 ARHGEF10L KCNMA1 DTX2 B4GALNT3 MCF2L NKAPL	2.22e-07	198	140	8	1fe60443c11d34b6d2671af8f06e0dedc8d1558b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NYAP2 NRXN3 HMCN2 NRXN1 KCNG1 ST6GALNAC5 KCNMA1	5.89e-07	154	140	7	30cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NYAP2 NRXN3 HMCN2 NRXN1 KCNG1 ST6GALNAC5 KCNMA1	5.89e-07	154	140	7	ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NYAP2 NRXN3 HMCN2 NRXN1 KCNG1 ST6GALNAC5 KCNMA1	5.89e-07	154	140	7	42bd8f88fd075a2d4edde394785decad88a2660a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NYAP2 NRXN3 HMCN2 NRXN1 KCNG1 ST6GALNAC5 KCNMA1	5.89e-07	154	140	7	6425d9861148586466febd6eceae1b1f9b9a14c1
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MEF2B WBP2NL DBH STAC NRXN1 TLL2 C2CD4D	1.29e-06	173	140	7	23e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC CAPN3 MAP3K20 HMCN2 KCNG1 ST6GALNAC5 KCNMA1	2.85e-06	195	140	7	bd7526dd80a60ff7bc866e4f5a0e8acdbc10d191
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT7 KRT16 VEPH1 PRSS36 EDN3 KCNG1	1.21e-05	161	140	6	1e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT16 NUDT22 HRNR ADORA2A MOXD1 SYTL1	1.54e-05	168	140	6	29a6c3ba69e03ccb19efb8ac177b9a162dc1ea43
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT16 NUDT22 HRNR ADORA2A MOXD1 SYTL1	1.54e-05	168	140	6	4297be958a4754677df7cf73feba19b0d76f1b4a
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT16 NUDT22 HRNR ADORA2A MOXD1 SYTL1	1.88e-05	174	140	6	84f2ffe867f22d2fa79f28737a0aa42bdf2f4804
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT3 MAP3K20 SMTN MOXD1 NRXN3 KCNMA1	2.20e-05	179	140	6	e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 CAPN3 PRSS36 ARHGEF10L AFAP1 KCNG1	2.27e-05	180	140	6	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	Basal\|World / shred by cell class for mouse tongue	MAP3K20 NEDD4 MOXD1 AFAP1 UCP2 SNAI2	2.49e-05	183	140	6	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT7 VEPH1 PRSS36 EDN3 NRXN3 PLEKHA7	2.49e-05	183	140	6	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	18-Airway-Epithelial-Club-like_secretory\|Airway / Age, Tissue, Lineage and Cell class	KRT7 KRT16 PAQR4 MUC16 ST6GALNAC5 DTX2	2.81e-05	187	140	6	d1e301afcc39054ae1f867d80e564e30a137e3f8
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CACNA1E NYAP2 GRIN2D NRXN3 ST6GALNAC5 CNTNAP2	2.90e-05	188	140	6	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FAT3 ARHGEF10L SMTN HMCN2 ST6GALNAC5 KCNMA1	2.99e-05	189	140	6	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KRT7 NYAP2 MMRN1 NRXN1 ST6GALNAC5 KCNMA1	3.08e-05	190	140	6	b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT3 MAP3K20 SMTN MOXD1 NRXN3 KCNMA1	3.17e-05	191	140	6	de2cd94ee88a7754f86d39469e38374d668210c7
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	BOC MAP3K20 ARHGEF17 SNAI2 CHST2 PDLIM2	3.17e-05	191	140	6	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	Bronchial-10x5prime-Stromal-Schwann-Schwann_nonmyelinating\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EID2 ARHGEF17 SMTN NRXN3 NRXN1	3.30e-05	116	140	5	b0a3c109c5f20ab699e53bf8ab3903d102f5f315
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP3K20 SMTN ARHGAP6 GLI1 SNAI2 CTNND2	3.36e-05	193	140	6	146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF17 AFAP1 NRXN3 NRXN1 ADAMTSL4 SPRN	3.46e-05	194	140	6	415801a3dfacf05f2b603fb424df3d045190a812
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF17 AFAP1 NRXN3 NRXN1 ADAMTSL4 SPRN	3.46e-05	194	140	6	256cb33ec90328f2704921fb0fe0fd9812e138b0
ToppCell	droplet-Liver-LIVER-NPC-1m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF17 AFAP1 NRXN3 NRXN1 ADAMTSL4 SPRN	3.46e-05	194	140	6	7942bc83c1bdca687795b91aa232824d603f9b09
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN3 MAP3K20 HMCN2 KCNG1 ST6GALNAC5 KCNMA1	3.56e-05	195	140	6	8a04f0e92d10a368ccda5f566ae67ef51f1d34a9
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E NYAP2 HECW1 FAT3 KCNH3 CNTNAP2	3.56e-05	195	140	6	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 KRT16 CAPN1 MUC16 NUDT8 SYTL1	3.56e-05	195	140	6	24d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell	PCW_10-12\|World / Celltypes from embryonic and fetal-stage human lung	FAT3 NAPRT CNTNAP2 ADAM17 CHST2 NIPBL	3.76e-05	197	140	6	47fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAPN3 MAP3K20 SMTN NRXN3 HMCN2 KCNMA1	3.76e-05	197	140	6	5a63c2b824c7d0dbbc706e408459c9b9fe65daaa
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 MAP3K20 NEDD4 MOXD1 AFAP1 SNAI2	3.87e-05	198	140	6	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KRT7 PAQR4 MUC16 NUDT8 UCP2 DTX2	3.98e-05	199	140	6	73704e8d774b3d08a311f69137972b07015c38f6
ToppCell	wk_08-11-Mesenchymal-Fibroblast-intermediate_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FAT3 MOXD1 SNAI2 CNTNAP2 CHST2 PDLIM2	3.98e-05	199	140	6	f9e3fb974ba8fe1b6d99892577549ef143df9e08
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NAALADL1 SRA1 PRSS36 ADORA2A UCP2 RAVER1	4.10e-05	200	140	6	88d713dfc792e7609bf7ecfb28f87cb748088570
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1E MUC16 SLC25A16 KCNMA1 CTNND2 MCF2L	4.10e-05	200	140	6	c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1E NYAP2 SRCIN1 NRXN3 CNTNAP2 MCF2L	4.10e-05	200	140	6	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADNP NEDD4 NCOR2 PHLDB1 SCML1 MAPKBP1	4.10e-05	200	140	6	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCell	Neuronal-Inhibitory-iB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CNTNAP3B GRIN2D AFAP1 NRXN3 CNTNAP2 PRRT4	4.10e-05	200	140	6	45ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT7 KRT16 HIPK1 GRIN2D PRSS36	4.90e-05	126	140	5	cde3b0fbdc324120e45e295eb171ee550653de47
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-7\|TCGA-Stomach / Sample_Type by Project: Shred V9	FAT3 STAC NRXN3 KCNMA1 NKAPL	5.09e-05	127	140	5	5e4d110cc6e68cd8fc7a4771a65e6f8cd83e7721
ToppCell	LA-10._Endothelium_II\|World / Chamber and Cluster_Paper	MMRN1 HMCN2 NRXN1 KCNMA1 MCF2L	5.28e-05	128	140	5	071becbe97598c2b65580b0989eb664d6fd6c85a
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD8-positive,_alpha-beta_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PAQR4 MUC16 CA13 SMTN GLI1	7.05e-05	136	140	5	9d7080f695de4ef183e3dbdc18ba464a3b8e3469
ToppCell	frontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NKX6-2 PHLDB1 TLL2 ADAMTSL4 PDLIM2	7.30e-05	137	140	5	b03f19b233c1c809f2cd2b4a7642eeaf254a6289
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	MUC16 NRXN3 NRXN1 CNTNAP2 CTNND2	7.81e-05	139	140	5	64c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CACNA1E FAT3 CAPN1 KCNH3 KCNG1	1.02e-04	147	140	5	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NYAP2 APBA2 DCHS1 CHST2 TDP1	1.27e-04	154	140	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT3 ARHGAP6 HMCN2 GLI1 NKAPL	1.30e-04	155	140	5	cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	FAT3 NRXN3 NRXN1 CNTNAP2 CTNND2	1.47e-04	159	140	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 VEPH1 SRCIN1 CNTNAP2 PLEKHA7	1.51e-04	160	140	5	41d6c811c445c0ba9b6a2deb10a3b6b793172582
ToppCell	facs-Heart-RV-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 VEPH1 SRCIN1 CNTNAP2 PLEKHA7	1.51e-04	160	140	5	c1d03c0ac9c12615a06499209fcdf18e9b6f1fba
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRCIN1 NRXN3 NRXN1 ST6GALNAC5 CNTNAP2	1.56e-04	161	140	5	7d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRCIN1 NRXN3 NRXN1 ST6GALNAC5 CNTNAP2	1.56e-04	161	140	5	410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRCIN1 NRXN3 NRXN1 ST6GALNAC5 CNTNAP2	1.56e-04	161	140	5	71022485da6754a2b57b4c3e758e3de4c95cc292
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRCIN1 NRXN3 NRXN1 ST6GALNAC5 CNTNAP2	1.56e-04	161	140	5	59ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT3 PAQR4 FSIP2 CNTNAP2 B4GALNT3	1.80e-04	166	140	5	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT3 PAQR4 FSIP2 CNTNAP2 B4GALNT3	1.80e-04	166	140	5	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell	LPS-antiTNF-Epithelial_airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT7 KRT16 HIPK1 PLEKHG6 PLEKHA7	1.80e-04	166	140	5	eb942ed68677e55c46cb039046f45686d4062d7c
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT7 KRT16 HIPK1 PLEKHG6 PLEKHA7	1.80e-04	166	140	5	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT7 KRT16 HIPK1 PLEKHG6 PLEKHA7	1.80e-04	166	140	5	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT3 PAQR4 FSIP2 CNTNAP2 B4GALNT3	1.80e-04	166	140	5	4586d6725403f879fc96f67be579022587ce1906
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E HECW1 NRXN1 CNTNAP2 CTNND2	1.85e-04	167	140	5	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	EID2 STAC MMRN1 AFAP1 SCML1	1.85e-04	167	140	5	6c2dade24a88af04b2c90a7e4f8dd7ccea9e94d1
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRCIN1 STAC MOXD1 NRXN3 NRXN1	1.90e-04	168	140	5	95dc690c1987b05685d36e6bb20eb79308696e30
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	EID2 STAC MMRN1 AFAP1 SCML1	1.90e-04	168	140	5	d8f485f8459532a2cb0bef899e6569142cf75685
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KRT7 FAT3 VEPH1 NRXN3 CNTNAP2	1.95e-04	169	140	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	15-Airway-Epithelial-Club-like_secretory\|Airway / Age, Tissue, Lineage and Cell class	KRT7 KRT16 MUC16 CA13 PLEKHG6	2.01e-04	170	140	5	1418031cc4b4a87a48621eb53a3c819cd713ddd0
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT3 ARHGEF17 NRXN1 ADAMTS18 CHST2	2.01e-04	170	140	5	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	TCGA-Prostate-Solid_Tissue_Normal-Prostate_normal_tissue-Prostate_normal_tissue-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	LURAP1 STAC EDN3 SNAI2 NKAPL	2.06e-04	171	140	5	cafcb7714110cb361808dbe4b9a4963bb71f5129
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAALADL1 CEP192 EEF2KMT ADORA2A SEC22C	2.06e-04	171	140	5	f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCell	droplet-Lung-nan-21m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 ARHGEF10L GUCY2F UCP2 IL17RA	2.12e-04	172	140	5	51bea97564a33f0060c546c9be4bf8bf8f1660f6
ToppCell	E15.5-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CACNA1E DBH STAC MOXD1 ST6GALNAC5	2.12e-04	172	140	5	a8b33d8ebc56e442a2ad6ac7dafd0c887571bd95
ToppCell	droplet-Lung-nan-21m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 ARHGEF10L GUCY2F UCP2 IL17RA	2.12e-04	172	140	5	be4dd4ba8d7a651677c797c25fd75f14e627415a
ToppCell	ASK428-Immune-B_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	BOC MUC16 CA13 NUDT8 CLEC4C	2.23e-04	174	140	5	b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERFE ARHGAP6 PHLDB1 SNAI2 CTNND2	2.23e-04	174	140	5	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	BOC KCNH3 KCNG1 KRT77 ADAMTS18	2.29e-04	175	140	5	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	ASK428-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	BOC MUC16 CA13 NUDT8 CLEC4C	2.29e-04	175	140	5	e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	BOC KCNH3 KCNG1 KRT77 ADAMTS18	2.29e-04	175	140	5	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CNTNAP3B MAP3K20 GRIN2D NEDD4 ARHGAP6	2.36e-04	176	140	5	95d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	SMG1 NCOA3 WBP2NL NCOR2 ADAM17	2.36e-04	176	140	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC KRT16 CNTNAP2 ADAMTSL4 PDLIM2	2.42e-04	177	140	5	7af1a19692f7fe8f691178a4e57d62bc379e3d56
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 NEDD4 ARHGAP6 NAPRT ST6GALNAC5	2.42e-04	177	140	5	c1f838e425ebb04482829b1957e3c1347127e6de
ToppCell	Control-Epithelial_alveolar-AT_1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KRT7 VEPH1 PRSS36 NRXN3 ST6GALNAC5	2.48e-04	178	140	5	aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP3B CAPN2 NRXN3 TLL2 ST6GALNAC5	2.48e-04	178	140	5	a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCell	COVID-19_Mild-Hematopoietic_SC-HSPC\|COVID-19_Mild / Disease group, lineage and cell class	ARHGEF17 STAC NEDD4 MMRN1 SMIM10	2.55e-04	179	140	5	19fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF17 STAC NEDD4 MMRN1 SMIM10	2.55e-04	179	140	5	4bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCell	PBMC-Mild-Hematopoietic-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF17 STAC NEDD4 MMRN1 SMIM10	2.55e-04	179	140	5	2f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGEF17 STAC NEDD4 MMRN1 SMIM10	2.55e-04	179	140	5	3e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCell	COVID-19_Mild-Hematopoietic_SC\|COVID-19_Mild / Disease group, lineage and cell class	ARHGEF17 STAC NEDD4 MMRN1 SMIM10	2.55e-04	179	140	5	50a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LURAP1 ARHGEF10L NCOR2 NRXN1 MCF2L	2.61e-04	180	140	5	c72f15763ba707189e29c85db533557f01c7fdb1
ToppCell	5'-Adult-SmallIntestine-Neuronal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRCIN1 MOXD1 NRXN3 NRXN1 ST6GALNAC5	2.61e-04	180	140	5	5e6e38ee0758ef2342a6a821c78ed24b57bb7b11
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF17 EDN3 PHLDB1 NRXN1 CHST2	2.61e-04	180	140	5	0153667e44fdbc3c0d444dcb023069925a2b69a2
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF17 EDN3 PHLDB1 NRXN1 CHST2	2.61e-04	180	140	5	40a28b410f46215d6d7cf8a02a18078eb046b5b0
ToppCell	5'-Adult-SmallIntestine-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRCIN1 MOXD1 NRXN3 NRXN1 ST6GALNAC5	2.61e-04	180	140	5	b88cd7ae922782176c057342d1b9eb9b8e5e7204
ToppCell	5'-Adult-SmallIntestine-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRCIN1 MOXD1 NRXN3 NRXN1 ST6GALNAC5	2.61e-04	180	140	5	ebd6e719a03f25155fa8181be19469d04d6d10a6
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRCIN1 MOXD1 NRXN3 NRXN1 SPATA25	2.68e-04	181	140	5	3aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell	5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRCIN1 MOXD1 NRXN3 NRXN1 SPATA25	2.68e-04	181	140	5	997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGEF17 STAC NEDD4 MMRN1 SMIM10	2.68e-04	181	140	5	e7f7b519c2a01c15f26df11ec9b434c0d1630c7a
ToppCell	PBMC-Mild-Hematopoietic-HSPC-HSPC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARHGEF17 STAC NEDD4 MMRN1 SMIM10	2.68e-04	181	140	5	54a19cf6a3b752e2391feb8b316bebee0e602d17
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN1 CAPN2 CAPN3 EML3 KCNMA1	5.00e-07	36	129	5	DOID:11723 (implicated_via_orthology)
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN1 CAPN2 CAPN3	8.11e-07	5	129	3	DOID:0110821 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	CNTNAP3B MEF2B MEF2D NRXN3 NRXN1 CNTNAP2 CTNND2	4.95e-06	152	129	7	DOID:0060041 (implicated_via_orthology)
Disease	PITT-HOPKINS SYNDROME	NRXN1 CNTNAP2	5.67e-05	3	129	2	C1970431
Disease	smoking cessation	CACNA1E ZSWIM8 NYAP2 VEPH1 DBH NRXN3 NRXN1 KCNMA1	9.55e-05	325	129	8	EFO_0004319
Disease	Waardenburg Syndrome	EDN3 SNAI2	2.81e-04	6	129	2	C3266898
Disease	intellectual disability (implicated_via_orthology)	MEF2B CAPN2 CAPN3 MEF2D	3.33e-04	75	129	4	DOID:1059 (implicated_via_orthology)
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP3B CNTNAP2	5.22e-04	8	129	2	DOID:0060308 (implicated_via_orthology)
Disease	Autism Spectrum Disorders	NRXN3 NRXN1 CNTNAP2 ANKRD11	5.37e-04	85	129	4	C1510586
Disease	initial pursuit acceleration	ARHGEF10L NRXN3 CNTNAP2 KCNMA1	5.86e-04	87	129	4	EFO_0008434
Disease	Tendinopathy	CACNA1E CNTNAP2	6.69e-04	9	129	2	EFO_1001434
Disease	response to tamoxifen	CYP2D7 WBP2NL	6.69e-04	9	129	2	EFO_0009391
Disease	hereditary spastic paraplegia (implicated_via_orthology)	CAPN1 CAPN2 CAPN3	8.87e-04	43	129	3	DOID:2476 (implicated_via_orthology)
Disease	Semantic-Pragmatic Disorder	NRXN1 CNTNAP2	1.02e-03	11	129	2	C0454655
Disease	Auditory Processing Disorder, Central	NRXN1 CNTNAP2	1.02e-03	11	129	2	C0751257
Disease	Language Delay	NRXN1 CNTNAP2	1.02e-03	11	129	2	C0023012
Disease	Language Development Disorders	NRXN1 CNTNAP2	1.02e-03	11	129	2	C0023014
Disease	Speech Delay	NRXN1 CNTNAP2	1.02e-03	11	129	2	C0241210
Disease	Gastrointestinal Stromal Sarcoma	BOC HIPK1 GLI1	1.15e-03	47	129	3	C3179349
Disease	Gastrointestinal Stromal Tumors	BOC HIPK1 GLI1	1.38e-03	50	129	3	C0238198
Disease	putamen volume change measurement	CNTNAP2 DCHS1	1.43e-03	13	129	2	EFO_0021495
Disease	Metabolic Bone Disorder	KCNMA1 ANKRD11	1.67e-03	14	129	2	C0005944
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	CNTNAP2 RNF111	1.67e-03	14	129	2	OBA_2045142
Disease	Osteopenia	KCNMA1 ANKRD11	1.92e-03	15	129	2	C0029453
Disease	level of Phosphatidylethanolamine (16:0_20:4) in blood serum	NYAP2 RNF111	2.19e-03	16	129	2	OBA_2045137
Disease	major depressive disorder (is_implicated_in)	CNTNAP2 CTNND2	2.47e-03	17	129	2	DOID:1470 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	CAPN2 CAPN3 BBS4 PNPLA5 DCHS1	2.60e-03	215	129	5	DOID:9970 (implicated_via_orthology)
Disease	waist circumference	NYAP2 CAPN2 MOXD1 NRXN3 NRXN1 CNTNAP2 MEIOSIN	2.86e-03	429	129	7	EFO_0004342
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	NYAP2 CAPN3 NCOR2 ABCG5 RNF111	2.87e-03	220	129	5	EFO_0004529, EFO_0008317
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	NYAP2 CAPN3 NCOR2 ABCG5 RNF111	3.40e-03	229	129	5	EFO_0004639, EFO_0008317
Disease	urinary microalbumin measurement	SLC25A16 CNTNAP2	3.42e-03	20	129	2	EFO_0010967
Disease	brain age measurement	GALC NKX6-2	3.42e-03	20	129	2	EFO_0010602
Disease	visceral:subcutaneous adipose tissue ratio	NYAP2 CNTNAP2 ADAM17	3.61e-03	70	129	3	EFO_0004767
Disease	total blood protein measurement	NCOA3 ZSWIM8 MEF2B NYAP2 NCOR2 PMPCA ATXN1	3.68e-03	449	129	7	EFO_0004536
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	NCOR2 KCNMA1	3.77e-03	21	129	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	NYAP2 CAPN3 NCOR2 PMPCA ABCG5	4.08e-03	239	129	5	EFO_0008317, EFO_0020945

Protein segments in the cluster

Peptide	Gene	Start	Entry
PAGLSVSGRQSYLVG	nan	106	Q8N814
PSGNGRSYGLGSEQR	ADNP	371	Q9H2P0
AAYRTLPSGAGGTSQ	BBS4	476	Q96RK4
LQDGTLAAYPRTSGG	ARHGEF10L	941	Q9HCE6
GLSGIRAGYPLSERQ	ANKRD11	101	Q6UB99
SSNYLALRGPGGRSI	ADAMTSL4	521	Q6UY14
LQQDPVSGLSGRSGY	CACNA1E	1921	Q15878
SAQVGGNPLNRRYGS	B4GALNT3	46	Q6L9W6
RRPNGYALGLVSGGS	ADORA2A	356	P29274
RVISANPYLGGTSNG	AFAP1	476	Q8N556
ANGNTGASPYRLRRG	APBA2	201	Q99767
NKSVLRGGPLTGSYR	CA13	76	Q8N1Q1
SARQTFPPGRAASYG	AHDC1	916	Q5TGY3
SRRYGAPSSADLGLG	ATXN1	331	P54253
RRGSTAGGCRNYPAT	CAPN1	376	P07384
GRPRGIGYTIVSGNT	CDH23	266	Q9H251
QRPGSLAAGSRASYS	CTNND2	386	Q9UQB3
TRGSNYRFEGLGPTV	ERCC6	556	Q03468
YGSSGRPRRSAGKSQ	ADAMTS18	276	Q8TE60
QAAGAGGPTTRRDFY	SLC25A16	21	P16260
LRGSGLRGPLSHFYS	RAVER1	471	Q8IY67
PVYLRGGGGSSRRSS	RBM15B	216	Q8NDT2
GTYQPRLAGLTCSGA	NUDT8	196	Q8WV74
YLVGRRPAGGNSSGQ	KCNH3	411	Q9ULD8
YRSPSFGAGEGLLRS	ARHGEF17	416	Q96PE2
LYSGTPGGTRQSLAT	MUC16	3296	Q8WXI7
SPLFQRSSLGARYTG	MUC16	13961	Q8WXI7
RESSLALNYAAGPRG	NCOR2	1716	Q9Y618
PFSVGRYGGRVSLTG	DCHS1	2321	Q96JQ0
GALYLRVDSRAPGSG	DCHS1	2866	Q96JQ0
GELSGDNYLRSPGGR	IL17RA	551	Q96F46
YRSPASLRGGHAGTT	NRXN1	76	P58400
ALRGGYSTPQTLANR	KCNMA1	1081	Q12791
GILRRSISLGGAYPN	NEDD4	451	P46934
LYNRVQGSPTGAALG	NUDT22	281	Q9BRQ3
LSSARPGGLGSSSLY	KRT7	26	P08729
CLSGSRTGPVSGRYR	DTX2	201	Q86UW9
ITPTGYRAQRGGTSA	HIPK1	1026	Q86Z02
TGGVGNRAPRETYLS	MMRN1	171	Q13201
PYEGFAALRGSNGLR	HECW1	1541	Q76N89
LGARGSGYRVSPSGA	HMCN2	3891	Q8NDA2
RASISGRNYSLGSPD	FSIP2	6571	Q5CZC0
APARRNSVTTGYGGV	DLAT	41	P10515
TQGHRSYLLPSGGSV	EEF2KMT	106	Q96G04
GLNLTSGQYRAPVAG	ERFE	241	Q4G0M1
GGISRLPAGQATYRT	KAT14	531	Q9H8E8
GSNYPGLSISLRLTG	ECH1	21	Q13011
GRSSSRGPYESRLGH	HRNR	2676	Q86YZ3
INAGSNTPGSIRRYS	VEPH1	416	Q14D04
SGGGRYRNRSPSDSD	NIPBL	1141	Q6KC79
YGNSEPRLLGSRGVQ	NRXN3	181	Q9Y4C0
RAPSTYGGGLSVSSR	KRT16	41	P08779
QYSLTGGSPGRSRRG	LURAP1	111	Q96LR2
ARYASARGGGTSPTA	GLI1	591	P08151
AAAGRRKPGAGNSYL	KCNG1	321	Q9UIX4
AVNTYGAAPGGSRSR	NYAP2	491	Q9P242
RYLGSSEQPRANSLG	MEIOSIN	6	C9JSJ3
AGPRGGLNTSRSLYS	MEF2B	216	Q02080
LTGYRPASSGSGCLR	PAQR4	26	Q8N4S7
SARGATAGRLYSPSL	ARHGAP6	56	O43182
YLGRAGASSLPQGHQ	PRSS36	646	Q5K4E3
YVPFARGSGQARGLS	PLEKHG6	56	Q3KR16
ASGQPYLSGISGRAC	BOC	916	Q9BWV1
NYRGSFRGKRSAGPL	EDN3	131	P14138
PRGSRLGSFAGDVYS	GUCY2F	721	P51841
PLRLAYSSAGRGLSG	DMRTA1	436	Q5VZB9
GLAFGGPGSSRYLRL	DBH	316	P09172
SYHITGGNPRGRFAL	FAT3	2961	Q8TDW7
RLTISYCRSSGPGGQ	MRPL58	76	Q14197
PRGGQLRLSTEYQAG	C2CD4D	216	B7Z1M9
LLGAAAGQRSRPSTY	DNAJC4	21	Q9NNZ3
GNYSLGGISTGERRR	ABCG5	186	Q9H222
TRGGRLITNSYRSPG	CAPRIN2	866	Q6IMN6
RSRHGNGGLAALPYL	EID2	126	Q8N6I1
YGRGSISLNSSPRGR	MAP3K20	681	Q9NYL2
NSSSEGGALRRGPYR	MCF2L	591	O15068
ARGTLGRVYPGSRSS	MAPKBP1	976	O60336
GFYVANGSGLSPSAR	ITIH6	1226	Q6UXX5
IPSIRRLGSGYFSSN	CDCA2	606	Q69YH5
PGTSNSIGTGDSRRY	CEP192	306	Q8TEP8
LLGVAATLAPGSRGY	GADD45GIP1	11	Q8TAE8
PTGSLQIRYNLGGTR	CNTNAP2	1081	Q9UHC6
LSSPGGPGSRRSNYN	EML3	196	Q32P44
GPGSRRSNYNLEGIS	EML3	201	Q32P44
RSDRGSGQGDSLYPV	EMC4	31	Q5J8M3
SGRSSLGSHQLPRGY	BAG3	191	O95817
RRGSTAGGCRNYPNT	CAPN2	366	P17655
GGNPSGIYSAIISRN	CAPN3	36	P20807
VSGGGATSRLLVNYP	GALC	61	P54803
ALRLAQYPGRGSAEG	SEC22C	41	Q9BRL7
SFGGILSPGRSRAFT	CNTNAP3B	311	Q96NU0
VGNGYVSARASPGLL	MEF2D	221	Q14814
GGYPRSQASRPRINS	nan	731	A6NNC1
RLSLGTGSSYGLQVP	SYTL1	511	Q8IYJ3
RRFSSGGAYPNIPLS	PMPCA	31	Q10713
ATYGSSSGLCLGNPR	SCML1	201	Q9UN30
SGRCPLYGVATLNGS	TMEM179B	36	Q7Z7N9
ESYGNSRSAPLTRGP	RBMXL1	286	Q96E39
LNRYRQAGSSGPGNS	RPAIN	41	Q86UA6
RLNGLASSAGVYFGP	NKX6-2	81	Q9C056
GARRIYGSSSGALNA	PNPLA5	41	Q7Z6Z6
SSRDRGGSSSYGLQP	SMG1	46	Q96Q15
ARYGGSSNIASLTPG	NCOA3	431	Q9Y6Q9
NGLSPLSGYSSSLGR	SNAI2	71	O43623
YQTLPGRGLSGSTSR	PLEKHA7	1011	Q6IQ23
GQGERTGLPSSRYLS	PLEKHA7	1096	Q6IQ23
PGSRLSSGGTNYSRS	nan	6	Q6P435
APTRGYGRDVGNRTS	ST6GALNAC5	126	Q9BVH7
GSYSRLPFTALGSGQ	PSMB10	156	P40306
GYIFARRLSGQPSAG	SRMS	86	Q9H3Y6
NGYSRSRAPDLGGPS	SPATA25	106	Q9BR10
SYSGRPGSRQAGLGR	PDLIM2	171	Q96JY6
GTLGLAYVGSPRANS	ADAM17	346	P78536
FQLYSPAGSGGRNLT	CHST2	231	Q9Y4C5
RNSSYFLGLSDPGGR	CLEC4C	136	Q8WTT0
LLYFTGQRGARAPAG	CHPF2	131	Q9P2E5
GFGPRSQGVILSRYG	CYP2D7	111	A0A087X1C5
GALYPFSRSGSRGRL	NKAPL	61	Q5M9Q1
NVRTSLEGYPAGGSL	TDP1	446	Q9NUW8
SGPAAANGRTRAYSG	ZNRF2	6	Q8NHG8
ANGRTRAYSGSDLPS	ZNRF2	11	Q8NHG8
QSRGYGAQRAPGGLS	YIF1B	46	Q5BJH7
SGPAGLTLGRSFSNY	SEPHS2	21	Q99611
RTEGPRSLYNGLVAG	UCP2	71	P55851
GRGSRVTHLLGYPTQ	VSIG8	336	P0DPA2
TAAGGSGRTYPHRTL	MOXD1	16	Q6UVY6
RYISSGLDGTSFRGP	RNF111	861	Q6ZNA4
QSGSPSRSRLSYAGG	SRCIN1	321	Q9C0H9
RYGAPGSSLRVAAAG	SPRN	56	Q5BIV9
GVNSRGDRGLFPASY	SNX18	41	Q96RF0
FSYGLQTQAGGPRRS	SRA1	21	Q9HD15
NGPGGGYDLRKRSNS	STAC	241	Q99469
AGYRASPAGSGARPQ	WBP2NL	271	Q6ICG8
SARYNRFSGGPSNLP	TRAF7	6	Q6Q0C0
SYVGRRGGGPQAISI	TLL2	216	Q9Y6L7
LPGLGLYRTASLGTG	PRRT4	756	C9JH25
RRAQGPDGGLTASTY	NAPRT	171	Q6XQN6
GRLSPAYSLGSLTGA	PHLDB1	536	Q86UU1
AVRLSRPQGTRGSYG	SMIM10	26	Q96HG1
SPGYRCRSLTGAGAR	nan	11	Q8N9P0
VPSRLALGSRGGYNG	ZSWIM8	1111	A7E2V4
SRLAGAPRGLYNSVD	MID2	471	Q9UJV3
FPISGARGGARGTRY	UCN3	81	Q969E3
GTRARGRQGYSLGSL	TREX2	161	Q9BQ50
ATLAGRLYSGRPNSG	SMTN	126	P53814
PFLRTYQRGTVTAGG	TARM1	126	B6A8C7
FGSRSLYNLGGSRSI	KRT77	56	Q7Z794
SGTPQGLLVYANRGA	NAALADL1	156	Q9UQQ1
GYNRSLATGKRPGGS	GRIN2D	611	O15399