Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	blue light photoreceptor activity	CRY2 CRY1	4.56e-07	2	14	2	GO:0009882
GeneOntologyMolecularFunction	DNA photolyase activity	CRY2 CRY1	4.56e-07	2	14	2	GO:0003913
GeneOntologyMolecularFunction	DNA (6-4) photolyase activity	CRY2 CRY1	4.56e-07	2	14	2	GO:0003914
GeneOntologyMolecularFunction	deoxyribodipyrimidine photo-lyase activity	CRY2 CRY1	4.56e-07	2	14	2	GO:0003904
GeneOntologyMolecularFunction	carbon-carbon lyase activity	CRY2 MLYCD CRY1	7.44e-06	56	14	3	GO:0016830
GeneOntologyMolecularFunction	photoreceptor activity	CRY2 CRY1	6.17e-05	17	14	2	GO:0009881
GeneOntologyMolecularFunction	lyase activity	CRY2 MLYCD CRY1	3.94e-04	212	14	3	GO:0016829
GeneOntologyMolecularFunction	FAD binding	CRY2 CRY1	4.25e-04	44	14	2	GO:0071949
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	CRY2 CRY1	1.92e-03	94	14	2	GO:0050660
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	MKRN3 LMO7 FBXO30	3.96e-03	473	14	3	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	MKRN3 LMO7 FBXO30	4.94e-03	512	14	3	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	MKRN3 LMO7 FBXO30	5.50e-03	532	14	3	GO:0016755
GeneOntologyMolecularFunction	nuclear receptor binding	CRY2 CRY1	7.37e-03	187	14	2	GO:0016922
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	CRY2 PUS1 CRY1	9.36e-03	645	14	3	GO:0140640
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	CRY2 CRY1	1.41e-02	262	14	2	GO:0140097
GeneOntologyMolecularFunction	phosphatase binding	CRY2 CRY1	1.43e-02	264	14	2	GO:0019902
GeneOntologyMolecularFunction	acyltransferase activity	MKRN3 LMO7 FBXO30	1.54e-02	775	14	3	GO:0016746
GeneOntologyBiologicalProcess	cellular response to blue light	CRY2 CRY1	4.28e-07	2	14	2	GO:0071483
GeneOntologyBiologicalProcess	blue light signaling pathway	CRY2 CRY1	4.28e-07	2	14	2	GO:0009785
GeneOntologyBiologicalProcess	negative regulation of corticosteroid hormone secretion	CRY2 CRY1	4.27e-06	5	14	2	GO:2000847
GeneOntologyBiologicalProcess	negative regulation of steroid hormone secretion	CRY2 CRY1	4.27e-06	5	14	2	GO:2000832
GeneOntologyBiologicalProcess	negative regulation of glucocorticoid secretion	CRY2 CRY1	4.27e-06	5	14	2	GO:2000850
GeneOntologyBiologicalProcess	negative regulation of glucocorticoid receptor signaling pathway	CRY2 CRY1	6.41e-06	6	14	2	GO:2000323
GeneOntologyBiologicalProcess	response to blue light	CRY2 CRY1	6.41e-06	6	14	2	GO:0009637
GeneOntologyBiologicalProcess	regulation of glucocorticoid receptor signaling pathway	CRY2 CRY1	2.81e-05	12	14	2	GO:2000322
GeneOntologyBiologicalProcess	regulation of glucocorticoid secretion	CRY2 CRY1	3.88e-05	14	14	2	GO:2000849
GeneOntologyBiologicalProcess	glucocorticoid secretion	CRY2 CRY1	5.11e-05	16	14	2	GO:0035933
GeneOntologyBiologicalProcess	negative regulation of circadian rhythm	CRY2 CRY1	5.11e-05	16	14	2	GO:0042754
GeneOntologyBiologicalProcess	nuclear receptor-mediated glucocorticoid signaling pathway	CRY2 CRY1	5.78e-05	17	14	2	GO:0042921
GeneOntologyBiologicalProcess	nuclear receptor-mediated corticosteroid signaling pathway	CRY2 CRY1	6.51e-05	18	14	2	GO:0031958
GeneOntologyBiologicalProcess	regulation of corticosteroid hormone secretion	CRY2 CRY1	8.92e-05	21	14	2	GO:2000846
GeneOntologyBiologicalProcess	corticosteroid hormone secretion	CRY2 CRY1	1.17e-04	24	14	2	GO:0035930
GeneOntologyBiologicalProcess	entrainment of circadian clock by photoperiod	CRY2 CRY1	1.27e-04	25	14	2	GO:0043153
GeneOntologyBiologicalProcess	photoperiodism	CRY2 CRY1	1.60e-04	28	14	2	GO:0009648
GeneOntologyBiologicalProcess	entrainment of circadian clock	CRY2 CRY1	1.84e-04	30	14	2	GO:0009649
GeneOntologyBiologicalProcess	regulation of steroid hormone secretion	CRY2 CRY1	1.84e-04	30	14	2	GO:2000831
GeneOntologyBiologicalProcess	steroid hormone secretion	CRY2 CRY1	2.51e-04	35	14	2	GO:0035929
GeneOntologyBiologicalProcess	negative regulation of intracellular steroid hormone receptor signaling pathway	CRY2 CRY1	3.29e-04	40	14	2	GO:0033144
GeneOntologyBiologicalProcess	negative regulation of lipid transport	CRY2 CRY1	6.45e-04	56	14	2	GO:0032369
GeneOntologyBiologicalProcess	carbohydrate metabolic process	PHKA2 MLYCD AKR7A2 CRY1	7.43e-04	646	14	4	GO:0005975
GeneOntologyBiologicalProcess	regulation of endocrine process	CRY2 CRY1	7.65e-04	61	14	2	GO:0044060
GeneOntologyBiologicalProcess	lipid export from cell	CRY2 CRY1	8.42e-04	64	14	2	GO:0140353
GeneOntologyBiologicalProcess	circadian regulation of gene expression	CRY2 CRY1	1.15e-03	75	14	2	GO:0032922
GeneOntologyBiologicalProcess	endocrine hormone secretion	CRY2 CRY1	1.22e-03	77	14	2	GO:0060986
GeneOntologyBiologicalProcess	negative regulation of lipid localization	CRY2 CRY1	1.25e-03	78	14	2	GO:1905953
GeneOntologyBiologicalProcess	regulation of intracellular steroid hormone receptor signaling pathway	CRY2 CRY1	1.55e-03	87	14	2	GO:0033143
GeneOntologyBiologicalProcess	response to activity	CRY2 CRY1	1.66e-03	90	14	2	GO:0014823
GeneOntologyBiologicalProcess	protein ubiquitination	MKRN3 LMO7 FBXO30 CRY1	1.73e-03	811	14	4	GO:0016567
GeneOntologyBiologicalProcess	negative regulation of hormone secretion	CRY2 CRY1	2.16e-03	103	14	2	GO:0046888
GeneOntologyBiologicalProcess	lipid storage	CRY2 CRY1	2.24e-03	105	14	2	GO:0019915
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	MKRN3 LMO7 FBXO30 CRY1	2.47e-03	893	14	4	GO:0032446
GeneOntologyBiologicalProcess	endocrine process	CRY2 CRY1	3.06e-03	123	14	2	GO:0050886
GeneOntologyBiologicalProcess	cellular response to light stimulus	CRY2 CRY1	3.41e-03	130	14	2	GO:0071482
GeneOntologyBiologicalProcess	regulation of glucose metabolic process	MLYCD CRY1	3.62e-03	134	14	2	GO:0010906
GeneOntologyBiologicalProcess	regulation of circadian rhythm	CRY2 CRY1	3.68e-03	135	14	2	GO:0042752
GeneOntologyBiologicalProcess	nuclear receptor-mediated steroid hormone signaling pathway	CRY2 CRY1	3.73e-03	136	14	2	GO:0030518
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	MKRN3 LMO7 FBXO30 CRY1	3.84e-03	1009	14	4	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	MKRN3 LMO7 FBXO30 CRY1	4.81e-03	1074	14	4	GO:0043687
GeneOntologyBiologicalProcess	steroid hormone receptor signaling pathway	CRY2 CRY1	4.81e-03	155	14	2	GO:0043401
GeneOntologyBiologicalProcess	regulation of lipid transport	CRY2 CRY1	6.36e-03	179	14	2	GO:0032368
GeneOntologyBiologicalProcess	positive regulation of small molecule metabolic process	MLYCD CRY1	7.29e-03	192	14	2	GO:0062013
GeneOntologyBiologicalProcess	cellular response to radiation	CRY2 CRY1	7.43e-03	194	14	2	GO:0071478
GeneOntologyBiologicalProcess	nuclear receptor-mediated signaling pathway	CRY2 CRY1	8.04e-03	202	14	2	GO:0141193
GeneOntologyBiologicalProcess	negative regulation of secretion by cell	CRY2 CRY1	8.98e-03	214	14	2	GO:1903531
GeneOntologyBiologicalProcess	regulation of lipid localization	CRY2 CRY1	9.06e-03	215	14	2	GO:1905952
Domain	DNA_photolyase	CRY2 CRY1	6.02e-07	2	15	2	PF00875
Domain	FAD_binding_7	CRY2 CRY1	6.02e-07	2	15	2	PF03441
Domain	PHR_CRY_ALPHA_BETA	CRY2 CRY1	6.02e-07	2	15	2	PS51645
Domain	DNA_photolyase_N	CRY2 CRY1	6.02e-07	2	15	2	IPR006050
Domain	Cryptochr/Photolyase_FAD-bd	CRY2 CRY1	6.02e-07	2	15	2	IPR005101
Domain	-	CRY2 CRY1	5.33e-04	43	15	2	3.40.50.620
Domain	Rossmann-like_a/b/a_fold	CRY2 CRY1	5.33e-04	43	15	2	IPR014729
Pathway	BIOCARTA_CIRCADIAN_PATHWAY	CRY2 CRY1	9.95e-06	6	12	2	M22067
Pathway	BIOCARTA_CIRCADIAN_PATHWAY	CRY2 CRY1	1.39e-05	7	12	2	MM1578
Pathway	KEGG_CIRCADIAN_RHYTHM_MAMMAL	CRY2 CRY1	5.15e-05	13	12	2	M18009
Pathway	PID_CIRCADIAN_PATHWAY	CRY2 CRY1	7.92e-05	16	12	2	M95
Pathway	WP_MELATONIN_METABOLISM_AND_EFFECTS	CRY2 CRY1	4.35e-04	37	12	2	M39418
Pathway	WP_EXERCISEINDUCED_CIRCADIAN_REGULATION	CRY2 CRY1	7.33e-04	48	12	2	M39444
Pathway	WP_EXERCISEINDUCED_CIRCADIAN_REGULATION	CRY2 CRY1	7.64e-04	49	12	2	MM15870
Pathway	REACTOME_CIRCADIAN_CLOCK	CRY2 CRY1	1.55e-03	70	12	2	M938
Pubmed	Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice.	CRY2 CRY1	2.25e-07	2	17	2	15893577
Pubmed	Cancer, hear my battle CRY.	CRY2 CRY1	2.25e-07	2	17	2	32291799
Pubmed	Deregulated expression of cry1 and cry2 in human gliomas.	CRY2 CRY1	2.25e-07	2	17	2	23317246
Pubmed	Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer.	CRY2 CRY1	2.25e-07	2	17	2	16061665
Pubmed	Daily variation in the electrophysiological activity of mouse medial habenula neurones.	CRY2 CRY1	2.25e-07	2	17	2	24247982
Pubmed	Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha.	CRY2 CRY1	2.25e-07	2	17	2	20042581
Pubmed	Mice deficient in cryptochrome 1 (cry1 (-/-)) exhibit resistance to obesity induced by a high-fat diet.	CRY2 CRY1	2.25e-07	2	17	2	24782829
Pubmed	Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine.	CRY2 CRY1	2.25e-07	2	17	2	18258761
Pubmed	Deregulated expression of cryptochrome genes in human colorectal cancer.	CRY2 CRY1	2.25e-07	2	17	2	26768731
Pubmed	Interval timing is intact in arrhythmic Cry1/Cry2-deficient mice.	CRY2 CRY1	2.25e-07	2	17	2	21775289
Pubmed	Synchronization of cellular clocks in the suprachiasmatic nucleus.	CRY2 CRY1	2.25e-07	2	17	2	14631044
Pubmed	Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines.	CRY2 CRY1	2.25e-07	2	17	2	22778400
Pubmed	Control of skin cancer by the circadian rhythm.	CRY2 CRY1	2.25e-07	2	17	2	22025708
Pubmed	Redox potential: differential roles in dCRY and mCRY1 functions.	CRY2 CRY1	2.25e-07	2	17	2	11818067
Pubmed	Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.	CRY2 CRY1	2.25e-07	2	17	2	28017587
Pubmed	Circadian oscillation of nucleotide excision repair in mammalian brain.	CRY2 CRY1	2.25e-07	2	17	2	19164551
Pubmed	Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis.	CRY2 CRY1	2.25e-07	2	17	2	32339698
Pubmed	Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.	CRY2 CRY1	2.25e-07	2	17	2	10518585
Pubmed	Delay in feedback repression by cryptochrome 1 is required for circadian clock function.	CRY2 CRY1	2.25e-07	2	17	2	21236481
Pubmed	CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome.	CRY2 CRY1	2.25e-07	2	17	2	25391456
Pubmed	Circadian intraocular pressure rhythm is generated by clock genes.	CRY2 CRY1	2.25e-07	2	17	2	16936122
Pubmed	Circadian time-place learning in mice depends on Cry genes.	CRY2 CRY1	2.25e-07	2	17	2	18514517
Pubmed	Autonomic and cardiovascular responses to scent stimulation are altered in cry KO mice.	CRY2 CRY1	2.25e-07	2	17	2	17175102
Pubmed	Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice.	CRY2 CRY1	2.25e-07	2	17	2	20825493
Pubmed	Altered phase-relationship between peripheral oscillators and environmental time in Cry1 or Cry2 deficient mouse models for early and late chronotypes.	CRY2 CRY1	2.25e-07	2	17	2	24386234
Pubmed	The ratio of intracellular CRY proteins determines the clock period length.	CRY2 CRY1	2.25e-07	2	17	2	26966073
Pubmed	A role for cryptochromes in sleep regulation.	CRY2 CRY1	2.25e-07	2	17	2	12495442
Pubmed	Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.	CRY2 CRY1	2.25e-07	2	17	2	9822380
Pubmed	Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.	CRY2 CRY1	2.25e-07	2	17	2	34446572
Pubmed	Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.	CRY2 CRY1	2.25e-07	2	17	2	10217146
Pubmed	The Potorous CPD photolyase rescues a cryptochrome-deficient mammalian circadian clock.	CRY2 CRY1	2.25e-07	2	17	2	21858120
Pubmed	Cognitive dysfunction, elevated anxiety, and reduced cocaine response in circadian clock-deficient cryptochrome knockout mice.	CRY2 CRY1	2.25e-07	2	17	2	24187535
Pubmed	Network features of the mammalian circadian clock.	CRY2 CRY1	2.25e-07	2	17	2	19278294
Pubmed	Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythms.	CRY2 CRY1	2.25e-07	2	17	2	12696673
Pubmed	Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase.	CRY2 CRY1	2.25e-07	2	17	2	15298678
Pubmed	Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.	CRY2 CRY1	2.25e-07	2	17	2	34172584
Pubmed	Measurement of internal body time by blood metabolomics.	CRY2 CRY1	2.25e-07	2	17	2	19487679
Pubmed	Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.	CRY2 CRY1	2.25e-07	2	17	2	8909283
Pubmed	Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei.	CRY2 CRY1	2.25e-07	2	17	2	12121621
Pubmed	The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.	CRY2 CRY1	2.25e-07	2	17	2	19211562
Pubmed	Expression of the blue-light receptor cryptochrome in the human retina.	CRY2 CRY1	2.25e-07	2	17	2	14507900
Pubmed	Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.	CRY2 CRY1	2.25e-07	2	17	2	28380384
Pubmed	Perspectives: neurobiology. The CRYs fo flies and mice.	CRY2 CRY1	2.25e-07	2	17	2	10636810
Pubmed	CRY1 and CRY2 genetic variants in seasonality: A longitudinal and cross-sectional study.	CRY2 CRY1	2.25e-07	2	17	2	27267441
Pubmed	Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock.	CRY2 CRY1	2.25e-07	2	17	2	12483519
Pubmed	Clock gene defect disrupts light-dependency of autonomic nerve activity.	CRY2 CRY1	2.25e-07	2	17	2	17964540
Pubmed	Circadian clock cryptochrome proteins regulate autoimmunity.	CRY2 CRY1	2.25e-07	2	17	2	29109286
Pubmed	The expression of clock genes cry1 and cry2 in human colorectal cancer and tumor adjacent tissues correlates differently dependent on tumor location.	CRY2 CRY1	2.25e-07	2	17	2	29940771
Pubmed	Vagal regulation of respiratory clocks in mice.	CRY2 CRY1	2.25e-07	2	17	2	17442820
Pubmed	Analysis of autophosphorylating kinase activities of Arabidopsis and human cryptochromes.	CRY2 CRY1	2.25e-07	2	17	2	17073458
Pubmed	Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner.	CRY2 CRY1	2.25e-07	2	17	2	22033214
Pubmed	Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains.	CRY2 CRY1	2.25e-07	2	17	2	18614689
Pubmed	Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.	CRY2 CRY1	2.25e-07	2	17	2	19940241
Pubmed	Reduced light response of neuronal firing activity in the suprachiasmatic nucleus and optic nerve of cryptochrome-deficient mice.	CRY2 CRY1	2.25e-07	2	17	2	22216107
Pubmed	Light signalling in cryptochrome-deficient mice.	CRY2 CRY1	2.25e-07	2	17	2	14712914
Pubmed	Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.	CRY2 CRY1	2.25e-07	2	17	2	27818260
Pubmed	Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.	CRY2 CRY1	2.25e-07	2	17	2	24344304
Pubmed	Characterization of photolyase/blue-light receptor homologs in mouse and human cells.	CRY2 CRY1	2.25e-07	2	17	2	9801304
Pubmed	The involvement of Cry1 and Cry2 genes in the regulation of the circadian body temperature rhythm in mice.	CRY2 CRY1	2.25e-07	2	17	2	15331384
Pubmed	Circadian rhythm of RNA N6-methyladenosine and the role of cryptochrome.	CRY2 CRY1	2.25e-07	2	17	2	26239657
Pubmed	Postnatal constant light compensates Cryptochrome1 and 2 double deficiency for disruption of circadian behavioral rhythms in mice under constant dark.	CRY2 CRY1	2.25e-07	2	17	2	24278295
Pubmed	Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus.	CRY2 CRY1	2.25e-07	2	17	2	23575670
Pubmed	High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.	CRY2 CRY1	2.25e-07	2	17	2	23531614
Pubmed	Further characterization of the phenotype of mCry1/mCry2-deficient mice.	CRY2 CRY1	2.25e-07	2	17	2	11587085
Pubmed	Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein.	CRY2 CRY1	6.74e-07	3	17	2	21193487
Pubmed	Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice.	CRY2 CRY1	6.74e-07	3	17	2	12699623
Pubmed	Lithium effects on circadian rhythms in fibroblasts and suprachiasmatic nucleus slices from Cry knockout mice.	CRY2 CRY1	6.74e-07	3	17	2	26930624
Pubmed	An in-depth neurobehavioral characterization shows anxiety-like traits, impaired habituation behavior, and restlessness in male Cryptochrome-deficient mice.	CRY2 CRY1	6.74e-07	3	17	2	32348614
Pubmed	Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction.	CRY2 CRY1	6.74e-07	3	17	2	15010208
Pubmed	Cryptochrome-dependent circadian periods in the arcuate nucleus.	CRY2 CRY1	6.74e-07	3	17	2	26542738
Pubmed	Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice.	CRY2 CRY1	6.74e-07	3	17	2	11114194
Pubmed	Daily variation of clock output gene activation in behaviorally arrhythmic mPer/mCry triple mutant mice.	CRY2 CRY1	6.74e-07	3	17	2	12916720
Pubmed	Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression.	CRY2 CRY1	6.74e-07	3	17	2	16970803
Pubmed	Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis.	CRY2 CRY1	6.74e-07	3	17	2	21628572
Pubmed	Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals.	CRY2 CRY1	6.74e-07	3	17	2	9600923
Pubmed	Cell-autonomous clock of astrocytes drives circadian behavior in mammals.	CRY2 CRY1	6.74e-07	3	17	2	30630934
Pubmed	Intrinsic and extrinsic cues regulate the daily profile of mouse lateral habenula neuronal activity.	CRY2 CRY1	6.74e-07	3	17	2	25194046
Pubmed	Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.	CRY2 CRY1	6.74e-07	3	17	2	11889036
Pubmed	The circadian clock coordinates ribosome biogenesis.	CRY2 CRY1	6.74e-07	3	17	2	23300384
Pubmed	Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock.	CRY2 CRY1	6.74e-07	3	17	2	21521686
Pubmed	Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice.	CRY2 CRY1	6.74e-07	3	17	2	12381662
Pubmed	Loss of cryptochrome reduces cancer risk in p53 mutant mice.	CRY2 CRY1	6.74e-07	3	17	2	19188586
Pubmed	Circadian regulation of cryptochrome genes in the mouse.	CRY2 CRY1	6.74e-07	3	17	2	10521578
Pubmed	Differential roles for cryptochromes in the mammalian retinal clock.	CRY2 CRY1	6.74e-07	3	17	2	29561690
Pubmed	CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping.	CRY2 CRY1	6.74e-07	3	17	2	33491228
Pubmed	Neuroglobin correlates with cryptochrome-1 in obstructive sleep apnea with primary aldosteronism.	CRY2 CRY1	6.74e-07	3	17	2	30235329
Pubmed	CRY1-CBS binding regulates circadian clock function and metabolism.	CRY2 CRY1	6.74e-07	3	17	2	32383312
Pubmed	Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.	CRY2 CRY1	6.74e-07	3	17	2	28813682
Pubmed	Reduced pupillary light responses in mice lacking cryptochromes.	CRY2 CRY1	6.74e-07	3	17	2	12522242
Pubmed	Circadian regulation of food-anticipatory activity in molecular clock-deficient mice.	CRY2 CRY1	6.74e-07	3	17	2	23145013
Pubmed	Regulation of apoptosis by the circadian clock through NF-kappaB signaling.	CRY2 CRY1	6.74e-07	3	17	2	21690409
Pubmed	Reduced alpha-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock.	CRY2 CRY1	6.74e-07	3	17	2	15860530
Pubmed	Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock.	CRY2 CRY1	6.74e-07	3	17	2	36866044
Pubmed	Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.	CRY2 CRY1	6.74e-07	3	17	2	12782655
Pubmed	PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus.	CRY2 CRY1	6.74e-07	3	17	2	17986006
Pubmed	Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.	CRY2 CRY1	6.74e-07	3	17	2	30487216
Pubmed	Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm.	CRY2 CRY1	6.74e-07	3	17	2	22549838
Pubmed	Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice.	CRY2 CRY1	6.74e-07	3	17	2	15523112
Pubmed	Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells.	CRY2 CRY1	6.74e-07	3	17	2	29874863
Pubmed	Coupling Controls the Synchrony of Clock Cells in Development and Knockouts.	CRY2 CRY1	6.74e-07	3	17	2	26588574
Interaction	FBXL21P interactions	CRY2 CRY1	1.72e-05	10	13	2	int:FBXL21P
Interaction	PSMD11 interactions	CRY2 PUS1 SETDB1 CRY1	5.84e-05	353	13	4	int:PSMD11
Interaction	FBXL3 interactions	CRY2 CRY1	9.64e-05	23	13	2	int:FBXL3
Interaction	PER3 interactions	CRY2 CRY1	1.05e-04	24	13	2	int:PER3
Cytoband	19q13.42	VN1R4 ZNF579	1.09e-03	125	18	2	19q13.42
Cytoband	Ensembl 112 genes in cytogenetic band chr21q22	KRTAP22-2 KRTAP21-1	9.43e-03	377	18	2	chr21q22
GeneFamily	Keratin associated proteins	KRTAP22-2 KRTAP21-1	1.91e-03	109	11	2	619
Drug	Un9	CRY2 CRY1	1.21e-06	3	15	2	CID006914666
Drug	E_8	CRY2 CRY1	6.16e-05	18	15	2	CID000046764
Drug	deazaflavin	CRY2 CRY1	6.88e-05	19	15	2	CID005376058
Drug	allopurinol	CRY2 CRY1	8.45e-05	21	15	2	CID000002094
Drug	3147-18-0	CRY2 CRY1	9.29e-05	22	15	2	CID005748545
Drug	tryptophan	CRY2 CRY1	9.29e-05	22	15	2	CID005460840
Drug	N-1-naphthylphthalamic acid	CRY2 CRY1	1.11e-04	24	15	2	CID000008594
Drug	bis(I,I-trifluoroacetoxy)iodobenzene	CRY2 CRY1	1.63e-04	29	15	2	CID000102317
Drug	PG-S	CRY2 CRY1	1.74e-04	30	15	2	CID000446796
Drug	CHEMBL466993	CRY2 CRY1	1.99e-04	32	15	2	CID005320808
Drug	zinc borate	CRY2 CRY1	1.99e-04	32	15	2	CID000159268
Drug	norflurazon	CRY2 CRY1	2.38e-04	35	15	2	CID000033775
Drug	Betonicine [515-25-3]; Down 200; 25.2uM; PC3; HT_HG-U133A	CRY2 SETDB1 MLYCD	2.73e-04	198	15	3	3745_DN
Drug	STOCK1N-35696; Down 200; 15uM; PC3; HT_HG-U133A	PHKA2 MLYCD AKR7A2	2.73e-04	198	15	3	6564_DN
Drug	Tocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; HL60; HT_HG-U133A	PHKA2 SETDB1 MLYCD	2.73e-04	198	15	3	1320_DN
Drug	5149715; Down 200; 10uM; MCF7; HT_HG-U133A_EA	CRY2 PHKA2 SETDB1	2.73e-04	198	15	3	890_DN
Drug	rosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A	CRY2 PHKA2 SETDB1	2.77e-04	199	15	3	6950_DN
Disease	Seasonal Affective Disorder	CRY2 CRY1	3.73e-05	16	17	2	C0085159
Disease	oleoylcarnitine measurement	LMO7 AKR7A2	5.31e-05	19	17	2	EFO_0021043
Disease	Myeloid Leukemia, Chronic	CRY2 CRY1	1.26e-04	29	17	2	C0023473
Disease	viral load	MKRN3 AKR7A2	2.74e-03	136	17	2	EFO_0010125
Disease	Colorectal Carcinoma	MKRN3 LMO7 FBXO30	7.11e-03	702	17	3	C0009402
Disease	Mental Depression	CRY2 CRY1	9.22e-03	254	17	2	C0011570
Disease	Depressive disorder	CRY2 CRY1	1.18e-02	289	17	2	C0011581

Protein segments in the cluster

Peptide	Gene	Start	Entry
LFPCLRHFGLRFYAY	AKR7A2	211	O43488
YFCPICGRLFNTYSE	CPXCR1	276	Q8N123
LSFCLRNLFFPLRYC	MUC22	1681	E2RYF6
VGPYRRCYFFSHCST	MLYCD	231	O95822
LYCNDCYLRFKSGRP	LMO7	1666	Q8WWI1
SPYLRFGCLSCRLFY	CRY2	271	Q49AN0
LSPYLRFGCLSCRLF	CRY1	251	Q16526
GSGYCGYRPFCFRRC	KRTAP21-1	61	Q3LI58
YACNFPCSYGRFLLA	KRTAP22-2	26	Q3LI68
PLAYYGCTYSQRRFC	FBXO30	556	Q8TB52
YGCCRFLRDGYKTPR	PHKA2	291	P46019
CDARTYCYLLPTFAF	PUS1	196	Q9Y606
LFYLPHVCSYTCLSR	SETDB1	571	Q15047
LRFCYYASRGVCFRG	MKRN3	241	Q13064
PRFLQYAKSCGRYRC	TOMT	251	Q8WZ04
YYSPSCREFCLSCPR	PIGH	21	Q14442
LLHYLSFYCTGCRLR	VN1R4	26	Q7Z5H5
CPTCGRLFRFPYYLS	ZNF579	46	Q8NAF0