Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-glutamine gamma-glutamyltransferase activity	TGM7 TGM5	9.47e-05	9	33	2	GO:0003810
GeneOntologyMolecularFunction	acyltransferase activity	RNF14 ZDHHC7 TGM7 RNF133 TGM5 NAA16 CHFR	2.28e-04	775	33	7	GO:0016746
HumanPheno	Tinnitus	TMC1 RET CLCN2 ANKH	1.58e-05	71	12	4	HP:0000360
Domain	Transglut_N	TGM7 TGM5	1.08e-04	9	33	2	PF00868
Domain	TRANSGLUTAMINASES	TGM7 TGM5	1.08e-04	9	33	2	PS00547
Domain	Transglutaminase_N	TGM7 TGM5	1.08e-04	9	33	2	IPR001102
Domain	Transglut_C	TGM7 TGM5	1.08e-04	9	33	2	PF00927
Domain	-	TGM7 TGM5	1.08e-04	9	33	2	3.90.260.10
Domain	Gln_gamma-glutamylTfrase_euk	TGM7 TGM5	1.08e-04	9	33	2	IPR023608
Domain	Transglutaminase_AS	TGM7 TGM5	1.08e-04	9	33	2	IPR013808
Domain	Transglutaminase_C	TGM7 TGM5	1.35e-04	10	33	2	IPR008958
Domain	TGc	TGM7 TGM5	1.65e-04	11	33	2	SM00460
Domain	Transglut_core	TGM7 TGM5	1.65e-04	11	33	2	PF01841
Domain	Transglutaminase-like	TGM7 TGM5	1.65e-04	11	33	2	IPR002931
Domain	Ig_E-set	TGM7 PLXND1 TGM5	8.10e-04	104	33	3	IPR014756
Pubmed	Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis.	RET GPC3	5.23e-06	4	33	2	11180950
Pubmed	Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system.	TMC1 RET	1.31e-05	6	33	2	36876911
Pubmed	Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z.	TGM7 TGM5	1.83e-05	7	33	2	11390390
Pubmed	HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.	TGM7 TGM5	2.44e-05	8	33	2	7906657
Pubmed	Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.	TGM7 TGM5	2.44e-05	8	33	2	7688299
Pubmed	The malformed kidney: disruption of glomerular and tubular development.	RET GPC3	4.78e-05	11	33	2	10668924
Pubmed	β-Catenin in the kidney stroma modulates pathways and genes to regulate kidney development.	PLXND1 RET	4.78e-05	11	33	2	37227110
Pubmed	Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.	PLXND1 RET	5.73e-05	12	33	2	25839327
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	MRPL39 SLC38A10 INTS12 PSMB3	6.67e-05	231	33	4	36597993
Pubmed	Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.	RET SPRED2 GPC3	2.56e-04	130	33	3	28705898
Pubmed	Conditionals by inversion provide a universal method for the generation of conditional alleles.	PLXND1 RET	3.02e-04	27	33	2	23918385
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	RNF14 RNF133 CHFR	3.83e-04	149	33	3	19549727
Pubmed	Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.	ZDHHC7 CLCN2 GPC3 PSMB3	7.22e-04	432	33	4	7671812
Pubmed	TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.	PLXND1 RET	9.19e-04	47	33	2	35462405
Cytoband	15q15.2	TGM7 TGM5	5.97e-05	16	33	2	15q15.2
Cytoband	2p25.3	COLEC11 SNTG2	6.77e-05	17	33	2	2p25.3
Cytoband	3q22.1	PLXND1 NEK11	4.24e-04	42	33	2	3q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2p25	COLEC11 SNTG2	3.79e-03	127	33	2	chr2p25
Cytoband	Ensembl 112 genes in cytogenetic band chr3q22	PLXND1 NEK11	4.27e-03	135	33	2	chr3q22
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	TGM7 TGM5	5.04e-03	147	33	2	chr15q15
GeneFamily	Transglutaminases	TGM7 TGM5	8.27e-05	9	28	2	773
Disease	sex interaction measurement, Crohn's disease	SPRED2 GPR35	6.51e-04	37	30	2	EFO_0000384, EFO_0008343
Disease	developmental disorder of mental health (implicated_via_orthology)	PLXND1 NAA16	1.14e-03	49	30	2	DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YMAWLSFTCCMASAV	GSG1	236	Q2KHT4
VWYCARCTRQMKRMA	INTS12	206	Q96CB8
TCAEQMYGMCESLWE	PSMB3	141	P49720
MYSWDCPMEQCKRNS	CD58	156	P19256
LTRMWYCSYCQGLMM	GPC3	256	P51654
NWMSICMYSCLRETV	PLXND1	1496	Q9Y4D7
EMQCMWFQTECISAY	NAA16	481	Q6N069
TEAAMKVRWNACYAM	HEATR6	966	Q6AI08
WSLACILYEMCCMNH	NEK11	216	Q8NG66
CTTMVPNMLCIFWFN	OR52N2	76	Q8NGI0
CCRMQQWTETRIYMT	GPR35	46	Q9HC97
CNWSSFNDETCLMMI	PEF1	146	Q9UBV8
MHTFCAACYSGWMER	CHFR	321	Q96EP1
CMALSLTLCFVMFWT	ANKH	331	Q9HCJ1
WNDVACHTTMYFMCE	COLEC11	251	Q9BWP8
CFMCCTTLLSMWLSN	SLC13A4	126	Q9UKG4
LLLVFCSWMTHQSCM	SLC38A10	41	Q9HBR0
SNCMCGQLSMRCWYD	EHMT1	1071	Q9H9B1
MNRCVCARMATVSWV	OR2K2	136	Q8NGT1
AYWRSCAMMMGCVIE	MRPL39	141	Q9NYK5
CCRASVVWMAYMNIS	RNF133	31	Q8WVZ7
MRVYIFLCLMCWVRS	LIPI	1	Q6XZB0
NMCWPCMIVEFSRYL	PRAMEF22	216	A3QJZ6
WCSLVCLSRIYMGMH	SGPP1	241	Q9BX95
TYMCSWQGEMLCFTV	SNTG2	431	Q9NY99
HTSMYFQCWAVMCCN	TMC1	606	Q8TDI8
MALVSWVMDYAIAAC	CLCN2	101	P51788
MQYFCWICMGSLSRA	RNF14	426	Q9UBS8
SCMWCADSMLYHCMS	SPRED2	341	Q7Z698
GQCWVFAAVMCTVMR	TGM5	276	O43548
CSEEMYRLMLQCWKQ	RET	976	P07949
CGMICAVMTWLLVAY	ZDHHC7	46	Q9NXF8
YGQCWVFASVMCTVM	TGM7	276	Q96PF1