Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coactivator activity	BCL9L KMT2D PPRC1 SMARCC1 WWTR1 KAT6B TOX2	7.47e-06	303	48	7	GO:0003713
GeneOntologyMolecularFunction	transcription coregulator activity	MED15 BCL9L KMT2D PPRC1 SMARCC1 WWTR1 KAT6B TOX2	5.24e-05	562	48	8	GO:0003712
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2D SETD1B	1.57e-04	8	48	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2D SETD1B	2.52e-04	10	48	2	GO:0140999
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2D SETD1B	1.05e-03	20	48	2	GO:0042800
GeneOntologyBiologicalProcess	mRNA processing	CASC3 WBP11 PRPF40B RBM26 SMN1 SF3A2 RBM20 SCAF4 CPSF7	5.14e-06	551	49	9	GO:0006397
GeneOntologyCellularComponent	nuclear protein-containing complex	MED15 BCL9L CASC3 KMT2D SETD1B PRPF40B UBAP2L SMARCC1 KDM6B SF3A2 CPSF7	2.28e-04	1377	48	11	GO:0140513
GeneOntologyCellularComponent	SCAR complex	ABI1 WASF3	3.36e-04	12	48	2	GO:0031209
GeneOntologyCellularComponent	MLL3/4 complex	KMT2D KDM6B	3.36e-04	12	48	2	GO:0044666
GeneOntologyCellularComponent	nuclear speck	CASC3 WBP11 SETD1B PRPF40B PRCC SF3A2	4.38e-04	431	48	6	GO:0016607
GeneOntologyCellularComponent	ribonucleoprotein granule	CASC3 UBAP2L SMN1 RBM20 DHX30	4.98e-04	287	48	5	GO:0035770
GeneOntologyCellularComponent	histone methyltransferase complex	KMT2D SETD1B KDM6B	6.83e-04	75	48	3	GO:0035097
GeneOntologyCellularComponent	U2-type prespliceosome	PRPF40B SF3A2	7.72e-04	18	48	2	GO:0071004
GeneOntologyCellularComponent	prespliceosome	PRPF40B SF3A2	7.72e-04	18	48	2	GO:0071010
GeneOntologyCellularComponent	nuclear body	CASC3 WBP11 SETD1B PRPF40B PRCC SMN1 WWTR1 SF3A2	9.55e-04	903	48	8	GO:0016604
GeneOntologyCellularComponent	U2-type spliceosomal complex	CASC3 PRPF40B SF3A2	1.44e-03	97	48	3	GO:0005684
GeneOntologyCellularComponent	methyltransferase complex	KMT2D SETD1B KDM6B	1.96e-03	108	48	3	GO:0034708
GeneOntologyCellularComponent	Sm-like protein family complex	PRPF40B SMN1 SF3A2	2.58e-03	119	48	3	GO:0120114
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	CASC3 UBAP2L SMN1 RBM20	3.35e-03	269	48	4	GO:0036464
GeneOntologyCellularComponent	actin-based cell projection	ABI1 ESPNL FMN2 SHTN1	3.76e-03	278	48	4	GO:0098858
Domain	RRM	SETD1B PPRC1 RBM26 RBM20 SCAF4 CPSF7	1.87e-05	217	48	6	SM00360
Domain	RRM_dom	SETD1B PPRC1 RBM26 RBM20 SCAF4 CPSF7	2.42e-05	227	48	6	IPR000504
Domain	RRM	SETD1B PPRC1 RBM26 RBM20 SCAF4 CPSF7	2.60e-05	230	48	6	PS50102
Domain	-	SETD1B PPRC1 RBM26 RBM20 SCAF4 CPSF7	3.62e-05	244	48	6	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SETD1B PPRC1 RBM26 RBM20 SCAF4 CPSF7	4.95e-05	258	48	6	IPR012677
Domain	ZnF_U1	ZFHX4 SF3A2 RBM20	5.55e-05	29	48	3	SM00451
Domain	Znf_U1	ZFHX4 SF3A2 RBM20	5.55e-05	29	48	3	IPR003604
Domain	FF	PRPF40B ARHGAP35	9.64e-05	6	48	2	PF01846
Domain	FF	PRPF40B ARHGAP35	9.64e-05	6	48	2	SM00441
Domain	FF	PRPF40B ARHGAP35	9.64e-05	6	48	2	PS51676
Domain	FF_domain	PRPF40B ARHGAP35	9.64e-05	6	48	2	IPR002713
Domain	RNA_pol_II-bd	CHERP SCAF4	1.35e-04	7	48	2	IPR006903
Domain	CTD_bind	CHERP SCAF4	1.35e-04	7	48	2	PF04818
Domain	RPR	CHERP SCAF4	1.79e-04	8	48	2	SM00582
Domain	CID_dom	CHERP SCAF4	1.79e-04	8	48	2	IPR006569
Domain	CID	CHERP SCAF4	1.79e-04	8	48	2	PS51391
Domain	RRM_1	SETD1B PPRC1 RBM26 SCAF4 CPSF7	1.89e-04	208	48	5	PF00076
Domain	WW	PRPF40B FNBP4 WWTR1	2.39e-04	47	48	3	PF00397
Domain	WW	PRPF40B FNBP4 WWTR1	2.54e-04	48	48	3	SM00456
Domain	WW_DOMAIN_2	PRPF40B FNBP4 WWTR1	3.04e-04	51	48	3	PS50020
Domain	WW_DOMAIN_1	PRPF40B FNBP4 WWTR1	3.04e-04	51	48	3	PS01159
Domain	WW_dom	PRPF40B FNBP4 WWTR1	3.22e-04	52	48	3	IPR001202
Domain	Znf_C2H2_matrin	SF3A2 RBM20	4.20e-04	12	48	2	IPR000690
Domain	WH2	WASF3 LMOD1	5.77e-04	14	48	2	SM00246
Domain	Post-SET_dom	KMT2D SETD1B	7.58e-04	16	48	2	IPR003616
Domain	WH2	WASF3 LMOD1	7.58e-04	16	48	2	PF02205
Domain	PostSET	KMT2D SETD1B	7.58e-04	16	48	2	SM00508
Domain	POST_SET	KMT2D SETD1B	7.58e-04	16	48	2	PS50868
Domain	ZF_MATRIN	SF3A2 RBM20	9.64e-04	18	48	2	PS50171
Domain	WH2_dom	WASF3 LMOD1	1.32e-03	21	48	2	IPR003124
Domain	WH2	WASF3 LMOD1	1.72e-03	24	48	2	PS51082
Domain	-	CHERP SCAF4	2.02e-03	26	48	2	1.25.40.90
Domain	ENTH_VHS	CHERP SCAF4	2.51e-03	29	48	2	IPR008942
Domain	SET	KMT2D SETD1B	4.98e-03	41	48	2	PF00856
Domain	SET	KMT2D SETD1B	6.23e-03	46	48	2	SM00317
Domain	SET_dom	KMT2D SETD1B	7.32e-03	50	48	2	IPR001214
Domain	SET	KMT2D SETD1B	7.32e-03	50	48	2	PS50280
Domain	HMG_box	KMT2D TOX2	8.20e-03	53	48	2	PF00505
Domain	HMG	KMT2D TOX2	8.50e-03	54	48	2	SM00398
Domain	-	KMT2D TOX2	8.81e-03	55	48	2	1.10.30.10
Domain	HMG_box_dom	KMT2D TOX2	1.21e-02	65	48	2	IPR009071
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	CASC3 WBP11 CHERP PRCC SF3A2 CPSF7	1.38e-04	277	41	6	MM15414
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2D SETD1B SMARCC1 KDM6B KAT6B	1.45e-04	175	41	5	MM14941
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	CASC3 WBP11 CHERP PRCC SF3A2 CPSF7	1.55e-04	283	41	6	M13087
Pathway	REACTOME_MRNA_SPLICING	CASC3 WBP11 CHERP PRCC SF3A2	2.77e-04	201	41	5	MM15411
Pathway	REACTOME_MRNA_SPLICING	CASC3 WBP11 CHERP PRCC SF3A2	3.54e-04	212	41	5	M14033
Pathway	KEGG_SPLICEOSOME	WBP11 CHERP PRPF40B SF3A2	4.92e-04	127	41	4	M2044
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	WBP11 ABI1 IRS4 CHERP PRCC FNBP4 SMARCC1 FMN2 ARHGAP35 SHTN1 SF3A2 SCAF4 CPSF7	1.83e-13	506	49	13	30890647
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WBP11 ABI1 CHERP UBAP2L SMARCC1 SF3A2 SCAF4 DHX30 CPSF7	9.12e-13	154	49	9	16055720
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MED15 KMT2D IRS4 UBAP2L RBM26 FNBP4 SMARCC1 WWTR1 ARHGAP35 SHTN1 SCAF4	2.33e-10	549	49	11	38280479
Pubmed	Human transcription factor protein interaction networks.	MED15 BCL9L WBP11 KMT2D IRS4 ZFHX4 PRCC UBAP2L SMARCC1 SMN1 RBM20 SCAF4 DHX30 CPSF7	6.42e-09	1429	49	14	35140242
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PDE4A KMT2D SETD1B MARVELD1 TULP4 PPRC1 MFN2 TBC1D25 ARHGAP35 KDM6B WNK2 DHX30	3.11e-08	1105	49	12	35748872
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	KMT2D SETD1B RBM26 SMARCC1 SCAF4 DHX30 CPSF7	6.22e-08	251	49	7	31076518
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CASC3 WBP11 PDE4A ABI1 PRR36 UBAP2L SMARCC1 MFN2 GRM1 SHTN1 WNK2	7.72e-08	963	49	11	28671696
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED15 BCL9L KMT2D CHERP RBM26 SMARCC1 CPSF7	9.72e-08	268	49	7	33640491
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	MED15 BCL9L CASC3 WBP11 PRCC FNBP4 SMARCC1 CPSF7	1.35e-07	425	49	8	24999758
Pubmed	OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.	TULP4 UBAP2L SMARCC1 WWTR1 CPSF7	1.91e-07	91	49	5	30472188
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	MED15 BCL9L KMT2D PRPF40B SMARCC1 WWTR1 RBM20 CPSF7	2.35e-07	457	49	8	32344865
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	GORASP2 IRS4 CHERP PRCC UBAP2L RBM26 ARHGAP35 SHTN1 SCAF4 DHX30	5.91e-07	934	49	10	33916271
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	WBP11 IRS4 CHERP PRCC UBAP2L RBM26 FNBP4 SMARCC1 SCAF4 CPSF7	7.17e-07	954	49	10	36373674
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2D SETD1B KDM6B KAT6B	1.30e-06	57	49	4	18022353
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	WBP11 CHERP UBAP2L RBM26 SMARCC1 SF3A2 CPSF7	1.41e-06	399	49	7	35987950
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CASC3 WBP11 CHERP UBAP2L RBM26 SF3A2 SCAF4 DHX30 CPSF7	1.67e-06	807	49	9	22681889
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	IRS4 SETD1B UBAP2L FNBP4 SMARCC1 SMN1 DHX30	2.69e-06	440	49	7	34244565
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KMT2D SETD1B SMARCC1 KDM6B KAT6B	2.86e-06	157	49	5	30186101
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	CASC3 WBP11 PRCC RBM26 SF3A2 SCAF4 DHX30 CPSF7	3.39e-06	653	49	8	33742100
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	CASC3 WBP11 IRS4 CHERP WASF3 SMARCC1 SCAF4 DHX30 CPSF7	4.93e-06	922	49	9	27609421
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	MED15 BCL9L CHERP WWTR1 CPSF7	5.57e-06	180	49	5	35198878
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	KMT2D PRCC RBM26 SMN1 KAT6B SF3A2	8.33e-06	341	49	6	32971831
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	WBP11 CHERP PRCC SMN1 SF3A2	8.63e-06	197	49	5	22365833
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	SETD1B PPRC1 RBM26 SCAF4 DHX30 CPSF7	9.20e-06	347	49	6	16033648
Pubmed	Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion.	ABI1 WASF3	1.16e-05	4	49	2	19200726
Pubmed	The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.	ABI1 WASF3	1.16e-05	4	49	2	17664349
Pubmed	Understanding the Role of the SMN Complex Component GEMIN5 and Its Functional Relationship with Demethylase KDM6B in the Flunarizine-Mediated Neuroprotection of Motor Neuron Disease Spinal Muscular Atrophy.	SMN1 KDM6B	1.16e-05	4	49	2	39337533
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FNBP1 KMT2D UBAP2L FNBP4 SMARCC1 ARHGAP35 KAT6B SCAF4	1.17e-05	774	49	8	15302935
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ABI1 IRS4 UBAP2L RBM26 SMARCC1 SHTN1 SCAF4	1.29e-05	560	49	7	35241646
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	SMARCC1 SF3A2 SCAF4 DHX30 CPSF7	1.47e-05	220	49	5	24550385
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	WBP11 CHERP FNBP4 SMARCC1 ARHGAP35 SF3A2 SCAF4 DHX30 CPSF7	1.77e-05	1082	49	9	38697112
Pubmed	TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.	MED15 WWTR1	1.94e-05	5	49	2	18568018
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MED15 FNBP1 WBP11 KMT2D RBM26 SMARCC1 SF3A2 SCAF4 CPSF7	2.06e-05	1103	49	9	34189442
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	WBP11 CHERP PRCC SF3A2	2.14e-05	115	49	4	17332742
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	MED15 WBP11 GORASP2 UBAP2L KAT6B WNK2 CPSF7	2.19e-05	608	49	7	16713569
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNBP1 SETD1B PPRC1 UBAP2L MFN2 DHX30	2.26e-05	407	49	6	12693553
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	ABI1 CHERP TULP4 UBAP2L SMARCC1 DHX30 CPSF7	2.36e-05	615	49	7	31048545
Pubmed	Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression.	SMARCC1 KDM6B	2.91e-05	6	49	2	21095589
Pubmed	Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.	KMT2D CHERP	2.91e-05	6	49	2	8896557
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	FNBP1 CASC3 TULP4 UBAP2L WASF3 FNBP4 ARHGAP35 KAT6B SHTN1 WNK2	3.58e-05	1489	49	10	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MED15 BCL9L CASC3 GORASP2 ABI1 RBM26 SMN1 SF3A2 SCAF4 DHX30	3.75e-05	1497	49	10	31527615
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	FNBP1 UBAP2L SMARCC1 CPSF7	3.79e-05	133	49	4	15144186
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	WBP11 ABI1 IRS4 SMN1 DHX30	4.06e-05	272	49	5	25315684
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	IRS4 CHERP UBAP2L SMARCC1 DHX30	4.20e-05	274	49	5	34244482
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	CASC3 UBAP2L MFN2 SMN1 WNK2 DHX30	4.59e-05	462	49	6	31138677
Pubmed	Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.	FNBP1 TULP4 LMOD1 WWTR1	4.63e-05	140	49	4	26930384
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2D SETD1B	5.42e-05	8	49	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2D SETD1B	5.42e-05	8	49	2	22266653
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	IRS4 UBAP2L RBM26	6.20e-05	54	49	3	25631074
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2D SETD1B	6.96e-05	9	49	2	22665483
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	WBP11 IRS4 CHERP UBAP2L SF3A2 SCAF4 DHX30 CPSF7	8.49e-05	1024	49	8	24711643
Pubmed	A novel pro-Arg motif recognized by WW domains.	WBP11 FNBP4	8.69e-05	10	49	2	10744724
Pubmed	Identification and comparative analysis of hepatitis C virus-host cell protein interactions.	WBP11 GORASP2	1.06e-04	11	49	2	24136289
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CASC3 WBP11 UBAP2L RBM26 FNBP4 SMARCC1 SMN1 SCAF4 CPSF7	1.11e-04	1371	49	9	36244648
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2D SETD1B	1.27e-04	12	49	2	27563068
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	MED15 KMT2D SETD1B	1.29e-04	69	49	3	28481362
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FNBP1 IRS4 UBAP2L SMARCC1 SMN1 SF3A2 DHX30	1.32e-04	809	49	7	32129710
Pubmed	Interaction network of human early embryonic transcription factors.	MED15 BCL9L KMT2D ZFHX4 SMARCC1	1.35e-04	351	49	5	38297188
Pubmed	The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.	KMT2D PRR36	1.50e-04	13	49	2	36395886
Pubmed	The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology.	KMT2D KDM6B	1.75e-04	14	49	2	32541010
Pubmed	Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.	ABI1 GRM1	1.75e-04	14	49	2	21795692
Pubmed	Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.	FNBP1 FNBP4	1.75e-04	14	49	2	8605874
Pubmed	A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.	BCL9L AMELY	1.75e-04	14	49	2	28174279
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	ABI1 IRS4 UBAP2L RBM26 SMN1 SHTN1 SCAF4 CPSF7	1.87e-04	1149	49	8	35446349
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FNBP1 KMT2D ABI1 ZFHX4 RBM26 SMARCC1 WWTR1	1.88e-04	857	49	7	25609649
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	UBAP2L SMARCC1 TOX2 SF3A2	1.94e-04	203	49	4	22083510
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	WBP11 CHERP ZFHX4 FNBP4 SMARCC1 DHX30	2.00e-04	605	49	6	28977666
Pubmed	Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans.	RBM26 KCNK4	2.30e-04	16	49	2	20339383
Pubmed	Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.	ZFHX4 FEZF1	2.30e-04	16	49	2	33475140
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2D SETD1B	2.30e-04	16	49	2	24368734
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	MED15 KMT2D ZFHX4 SMARCC1 RBM20	2.41e-04	398	49	5	35016035
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MED15 FNBP1 KMT2D SMARCC1 LMOD1 TBC1D25	2.66e-04	638	49	6	31182584
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	WBP11 PRR36 UBAP2L SMARCC1 SMN1 ARHGAP35 SF3A2	2.81e-04	916	49	7	32203420
Pubmed	Putative Protein Interactome of the Rhomboid Protease RHBDL4.	GORASP2 IRS4	2.93e-04	18	49	2	36857408
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2D IRS4 ZFHX4 SHTN1 RBM20	3.02e-04	418	49	5	34709266
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	PRCC UBAP2L SMN1 DHX30 CPSF7	3.12e-04	421	49	5	34650049
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2D SETD1B	3.64e-04	20	49	2	29785026
Pubmed	The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.	ZFHX4 KDM6B	3.64e-04	20	49	2	35177643
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	WBP11 IRS4 CHERP UBAP2L SMARCC1 DHX30	3.68e-04	678	49	6	30209976
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	IRS4 UBAP2L FMN2 SF3A2	3.97e-04	245	49	4	35652658
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	WBP11 GORASP2 PPRC1 FMN2 KDM6B SHTN1 SF3A2 DHX30	3.98e-04	1285	49	8	35914814
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	IRS4 CHERP UBAP2L RBM26 SMARCC1 DHX30 CPSF7	4.00e-04	971	49	7	33306668
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2D KDM6B	4.01e-04	21	49	2	27626377
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KMT2D CHERP FNBP4 SMARCC1 WWTR1 SF3A2 SCAF4 CPSF7	4.17e-04	1294	49	8	30804502
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	IRS4 SMARCC1 AK9 SHTN1 WNK2	4.28e-04	451	49	5	36168627
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	MED15 PRCC SMARCC1 SMN1 CPSF7	4.36e-04	453	49	5	29656893
Pubmed	Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.	CHERP SF3A2	4.41e-04	22	49	2	26420826
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2D SETD1B	4.41e-04	22	49	2	26886794
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	WBP11 CHERP RBM26 SMARCC1 SF3A2 DHX30 CPSF7	4.46e-04	989	49	7	36424410
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	GORASP2 ABI1 IRS4 SF3A2 DHX30 CPSF7	4.49e-04	704	49	6	32994395
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	CASC3 CHERP RBM26 SCAF4 DHX30 CPSF7	4.80e-04	713	49	6	29802200
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	MED15 KMT2D	4.83e-04	23	49	2	9225980
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	CASC3 WBP11 UBAP2L SMN1 SF3A2 DHX30	4.84e-04	714	49	6	28302793
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BCL9L WBP11 KMT2D UBAP2L SMARCC1	5.11e-04	469	49	5	27634302
Pubmed	Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer.	FEZF1 GRM1	5.26e-04	24	49	2	25176648
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	CASC3 SF3A2 DHX30	5.66e-04	114	49	3	31553912
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	WBP11 GORASP2 PRCC SMN1 CPSF7	5.83e-04	483	49	5	27107014
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	IRS4 RBM26 SMN1 AK9 CPSF7	6.28e-04	491	49	5	36273042
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RBM26 FNBP4 AK9 SCAF4 CPSF7	6.64e-04	497	49	5	36774506
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	UBAP2L SMARCC1	7.71e-04	29	49	2	36800290
Interaction	ACTC1 interactions	WBP11 ABI1 IRS4 CHERP PRCC FNBP4 SMARCC1 FMN2 ARHGAP35 SHTN1 SF3A2 WNK2 SCAF4 CPSF7	6.41e-10	694	49	14	int:ACTC1
Interaction	SP7 interactions	BCL9L WBP11 KMT2D ZFHX4 PRCC SMARCC1 RBM20 SCAF4 DHX30 CPSF7	2.57e-09	304	49	10	int:SP7
Interaction	PRPF40A interactions	WBP11 ABI1 CHERP WASF3 FNBP4 SMARCC1 WWTR1 SF3A2 SCAF4 CPSF7	9.68e-08	446	49	10	int:PRPF40A
Interaction	YAP1 interactions	MED15 BCL9L KMT2D IRS4 TULP4 UBAP2L RBM26 FNBP4 SMARCC1 WWTR1 ARHGAP35 SHTN1 SCAF4 CPSF7	2.03e-07	1095	49	14	int:YAP1
Interaction	WBP4 interactions	WBP11 SETD1B CHERP SF3A2 SCAF4 CPSF7	2.52e-07	109	49	6	int:WBP4
Interaction	EWSR1 interactions	MED15 BCL9L CASC3 WBP11 GORASP2 CHERP PRCC UBAP2L FNBP4 SMARCC1 SMN1 CPSF7	1.26e-06	906	49	12	int:EWSR1
Interaction	SNRNP40 interactions	BCL9L WBP11 CHERP PRPF40B PRCC SMARCC1 SF3A2 RBM20 SCAF4 CPSF7	2.50e-06	637	49	10	int:SNRNP40
Interaction	PRMT2 interactions	WBP11 SETD1B KDM6B SHTN1 CPSF7	2.74e-06	91	49	5	int:PRMT2
Interaction	TLE3 interactions	MED15 BCL9L KMT2D CHERP PRPF40B RBM20 SCAF4 CPSF7	3.15e-06	376	49	8	int:TLE3
Interaction	GATA3 interactions	KMT2D ZFHX4 SMARCC1 RBM20 SCAF4 CPSF7	5.91e-06	187	49	6	int:GATA3
Interaction	TOP3B interactions	GORASP2 PDE4A KMT2D SETD1B MARVELD1 TULP4 PPRC1 UBAP2L MFN2 TBC1D25 ARHGAP35 KDM6B WNK2 DHX30	6.76e-06	1470	49	14	int:TOP3B
Interaction	APBB1 interactions	WBP11 ABI1 CHERP WWTR1 SF3A2 CPSF7	7.52e-06	195	49	6	int:APBB1
Interaction	NUP35 interactions	MED15 BCL9L KMT2D PRPF40B SMARCC1 WWTR1 RBM20 CPSF7	7.61e-06	424	49	8	int:NUP35
Interaction	SMC5 interactions	WBP11 IRS4 CHERP PRCC UBAP2L RBM26 FNBP4 SMARCC1 SMN1 SCAF4 CPSF7	2.18e-05	1000	49	11	int:SMC5
Interaction	CPSF6 interactions	WBP11 UBAP2L RBM26 SMARCC1 SMN1 SF3A2 SCAF4 CPSF7	3.59e-05	526	49	8	int:CPSF6
Interaction	NCK2 interactions	WBP11 ABI1 WASF3 RBM26 SF3A2 CPSF7	3.99e-05	262	49	6	int:NCK2
Interaction	SOX7 interactions	KMT2D ZFHX4 SMARCC1 RBM20	4.69e-05	82	49	4	int:SOX7
Interaction	TLX3 interactions	BCL9L KMT2D ZFHX4 ITIH6 TOX2 DHX30	7.14e-05	291	49	6	int:TLX3
Interaction	LHX2 interactions	BCL9L KMT2D ZFHX4 SMARCC1 DHX30	8.06e-05	183	49	5	int:LHX2
Interaction	FUBP1 interactions	CASC3 PRPF40B SMARCC1 SMN1 SF3A2 DHX30	9.94e-05	309	49	6	int:FUBP1
Interaction	NAA40 interactions	GORASP2 IRS4 CHERP PRCC UBAP2L RBM26 ARHGAP35 SHTN1 SCAF4 DHX30	1.01e-04	978	49	10	int:NAA40
Interaction	SNRNP70 interactions	CASC3 CHERP RBM26 SMARCC1 SMN1 ARHGAP35 SF3A2 SCAF4 DHX30 CPSF7	1.06e-04	984	49	10	int:SNRNP70
Interaction	KMT2A interactions	MED15 KMT2D SETD1B SMARCC1 WWTR1 KDM6B	1.09e-04	314	49	6	int:KMT2A
Interaction	JMJD6 interactions	CHERP UBAP2L RBM26 SCAF4 CPSF7	1.37e-04	205	49	5	int:JMJD6
Interaction	TRIP10 interactions	FNBP1 WBP11 ABI1 SF3A2	1.42e-04	109	49	4	int:TRIP10
Interaction	TCERG1 interactions	ABI1 SMN1 WWTR1 ARHGAP35 SF3A2	1.44e-04	207	49	5	int:TCERG1
Interaction	MEN1 interactions	KMT2D SETD1B CHERP PRCC RBM26 FNBP4 SMN1 KAT6B SF3A2 DHX30	1.53e-04	1029	49	10	int:MEN1
Interaction	RCOR1 interactions	FNBP1 KMT2D IRS4 ZFHX4 SMARCC1 SHTN1 RBM20	1.80e-04	494	49	7	int:RCOR1
Interaction	ITCH interactions	UBAP2L SMARCC1 SMN1 KDM6B SHTN1 CPSF7	2.15e-04	356	49	6	int:ITCH
Interaction	LUC7L interactions	CASC3 CHERP RBM26 SCAF4 CPSF7	2.97e-04	242	49	5	int:LUC7L
Interaction	SRPK2 interactions	BCL9L WBP11 CHERP ZFHX4 RBM26 SCAF4 DHX30 CPSF7	3.06e-04	717	49	8	int:SRPK2
Interaction	NXF1 interactions	FNBP1 CASC3 WBP11 UBAP2L RBM26 FNBP4 SMARCC1 MFN2 RBM20 DHX30 CPSF7	3.10e-04	1345	49	11	int:NXF1
Interaction	NEDD4 interactions	FNBP1 TULP4 UBAP2L SMARCC1 KDM6B SHTN1 DHX30	3.23e-04	544	49	7	int:NEDD4
Interaction	CFAP141 interactions	WBP11 RBM26 SCAF4	3.24e-04	55	49	3	int:CFAP141
Interaction	CRX interactions	MED15 BCL9L KMT2D ZFHX4 SMARCC1	3.71e-04	254	49	5	int:CRX
Interaction	HOMER3 interactions	ABI1 PRCC GRM1 TOX2	3.71e-04	140	49	4	int:HOMER3
Interaction	TNIP2 interactions	CASC3 WBP11 IRS4 CHERP WASF3 SMARCC1 SCAF4 DHX30 CPSF7	4.21e-04	952	49	9	int:TNIP2
Interaction	NCOA6 interactions	MED15 KMT2D SETD1B WWTR1	4.24e-04	145	49	4	int:NCOA6
Interaction	DAZL interactions	CASC3 UBAP2L RBM20 CPSF7	4.24e-04	145	49	4	int:DAZL
Interaction	EP300 interactions	CASC3 WBP11 KMT2D PRCC RBM26 SMARCC1 WWTR1 SF3A2 SCAF4 DHX30 CPSF7	4.40e-04	1401	49	11	int:EP300
Interaction	GEMIN5 interactions	MED15 SETD1B SMN1 WWTR1 KDM6B	4.66e-04	267	49	5	int:GEMIN5
Interaction	ARHGAP12 interactions	ABI1 WASF3 FNBP4	6.06e-04	68	49	3	int:ARHGAP12
GeneFamily	RNA binding motif containing	SETD1B PPRC1 RBM26 RBM20 SCAF4 CPSF7	9.44e-07	213	29	6	725
GeneFamily	Ataxins\|Trinucleotide repeat containing	MED15 KMT2D	7.28e-04	25	29	2	775
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D SETD1B	1.35e-03	34	29	2	487
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	WBP11 RBM26 GRM1	2.98e-03	181	29	3	694
GeneFamily	PHD finger proteins	KMT2D KAT6B	9.12e-03	90	29	2	88
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_100	IRS4 PRR36 FEZF1 SHTN1 TOX2	3.05e-06	100	48	5	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_100
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#1_top-relative-expression-ranked_500	ZFHX4 RBM26 SMARCC1 KDM6B	1.59e-05	67	48	4	gudmap_developingGonad_e12.5_ovary_k1_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#4_top-relative-expression-ranked_1000	IRS4 SETD1B ZFHX4 FMN2 RBM20	2.00e-05	147	48	5	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k4_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_100	IRS4 PRR36 FEZF1 TOX2	7.69e-05	100	48	4	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_100
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_500_k-means-cluster#2	PRR36 FMN2 TOX2 WNK2	7.69e-05	100	48	4	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_500_K2
CoexpressionAtlas	DevelopingGonad_e11.5_testes_emap-3226_top-relative-expression-ranked_1000	WBP11 GORASP2 ZFHX4 UBAP2L RBM26 SMARCC1 SMN1 KDM6B SF3A2	9.78e-05	843	48	9	gudmap_developingGonad_e11.5_testes_1000
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_top-relative-expression-ranked_1000	WBP11 GORASP2 ZFHX4 UBAP2L RBM26 FNBP4 SMARCC1 SMN1 KDM6B	9.87e-05	844	48	9	gudmap_developingGonad_e11.5_testes and mesonephros_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_500_k-means-cluster#3	PRR36 SHTN1 TOX2 WNK2	1.04e-04	108	48	4	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_500	IRS4 PRR36 FEZF1 FMN2 SHTN1 TOX2 WNK2	1.17e-04	496	48	7	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_500
CoexpressionAtlas	DevelopingGonad_e11.5_testes_emap-3226_k-means-cluster#1_top-relative-expression-ranked_500	ZFHX4 RBM26 KDM6B	1.17e-04	42	48	3	gudmap_developingGonad_e11.5_testes_k1_500
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#2_top-relative-expression-ranked_500	RBM26 SMARCC1 KDM6B	1.54e-04	46	48	3	gudmap_developingGonad_e12.5_epididymis_k2_500
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#1_top-relative-expression-ranked_500	RBM26 SMARCC1 KDM6B	1.97e-04	50	48	3	gudmap_developingGonad_e14.5_ epididymis_500_k1
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#1_top-relative-expression-ranked_1000	ZFHX4 RBM26 SMARCC1 KDM6B	2.12e-04	130	48	4	gudmap_developingGonad_e12.5_ovary_k1_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_500_k-means-cluster#5	PRR36 SHTN1 TOX2	2.35e-04	53	48	3	Facebase_RNAseq_e9.5_Olfactory Placode_500_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#2	CASC3 SETD1B PRR36 ARHGAP35 SHTN1 TOX2	2.53e-04	395	48	6	Facebase_RNAseq_e8.5_Floor Plate_2500_K2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_500	IRS4 SETD1B ZFHX4 FMN2	2.59e-04	137	48	4	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k2
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_top-relative-expression-ranked_500	GORASP2 ZFHX4 UBAP2L RBM26 SMN1 KDM6B	4.23e-04	435	48	6	gudmap_developingGonad_e11.5_testes and mesonephros_500
CoexpressionAtlas	facebase_RNAseq_e9.5_MandArch_2500_K3	PDE4A CHERP PPRC1 PRCC WASF3 SMARCC1 SMN1 SF3A2 RBM20 DHX30	4.28e-04	1259	48	10	facebase_RNAseq_e9.5_MandArch_2500_K3
CoexpressionAtlas	DevelopingGonad_e11.5_testes_emap-3226_top-relative-expression-ranked_500	GORASP2 ZFHX4 UBAP2L RBM26 SMN1 KDM6B	4.34e-04	437	48	6	gudmap_developingGonad_e11.5_testes_500
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_1000	ZFHX4 UBAP2L WASF3 RBM26 FNBP4 SMARCC1 SMN1 KDM6B	4.40e-04	815	48	8	gudmap_developingGonad_e11.5_ovary + mesonephros_1000
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#3_top-relative-expression-ranked_500	ZFHX4 RBM26 KDM6B	4.90e-04	68	48	3	gudmap_developingGonad_e11.5_ovary + mesonephros_k3_500
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#5_top-relative-expression-ranked_500	RBM26 FNBP4 KDM6B	5.79e-04	72	48	3	gudmap_developingGonad_e18.5_epididymis_500_k5
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_1000	GORASP2 IRS4 SETD1B CHERP ZFHX4 FMN2 KAT6B RBM20	5.81e-04	850	48	8	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_2500_k-means-cluster#2	TULP4 PRR36 FMN2 WWTR1 SHTN1 TOX2 WNK2	6.54e-04	659	48	7	Facebase_RNAseq_e10.5_Olfactory Pit_2500_K2
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_k-means-cluster#4_top-relative-expression-ranked_200	ZFHX4 RBM26	6.66e-04	17	48	2	gudmap_developingGonad_e11.5_testes and mesonephros_k4_200
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3	CASC3 SETD1B MFN2 ARHGAP35 TOX2	6.97e-04	314	48	5	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_2500_k-means-cluster#4	TULP4 PRR36 FMN2 WWTR1 SHTN1 TOX2 WNK2	8.07e-04	683	48	7	Facebase_RNAseq_e9.5_Olfactory Placode_2500_K4
CoexpressionAtlas	DevelopingGonad_e11.5_testes_emap-3226_k-means-cluster#5_top-relative-expression-ranked_1000	WBP11 GORASP2 UBAP2L RBM26 SMN1 SF3A2	8.60e-04	498	48	6	gudmap_developingGonad_e11.5_testes_k5_1000
CoexpressionAtlas	DevelopingGonad_e11.5_testes_emap-3226_k-means-cluster#2_top-relative-expression-ranked_200	ZFHX4 RBM26	9.26e-04	20	48	2	gudmap_developingGonad_e11.5_testes_k2_200
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	PRR36 SHTN1 TOX2 WNK2	9.97e-04	196	48	4	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000_K2
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4	TULP4 PRR36 FMN2 WWTR1 KAT6B SHTN1 WNK2	1.11e-03	721	48	7	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_500_k-means-cluster#4	PRR36 SHTN1 TOX2	1.11e-03	90	48	3	Facebase_RNAseq_e8.5_Floor Plate_500_K4
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#3	TULP4 PRR36 FMN2 WWTR1 KAT6B SHTN1 WNK2	1.19e-03	730	48	7	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5	TULP4 PRR36 FMN2 WWTR1 SHTN1 TOX2 WNK2	1.21e-03	732	48	7	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K5
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_k-means-cluster#5_top-relative-expression-ranked_1000	WBP11 GORASP2 UBAP2L RBM26 SMARCC1 SMN1	1.22e-03	533	48	6	gudmap_developingGonad_e11.5_testes and mesonephros_k5_1000
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#2	PRR36 FMN2 SHTN1 TOX2	1.29e-03	210	48	4	Facebase_RNAseq_e9.5_Olfactory Placode_1000_K2
CoexpressionAtlas	DevelopingGonad_e18.5_testes_emap-11164_k-means-cluster#3_top-relative-expression-ranked_1000	GORASP2 UBAP2L RBM26 FNBP4 SMN1	1.31e-03	362	48	5	gudmap_developingGonad_e18.5_testes_1000_k3
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	TULP4 PRR36 FMN2 WWTR1 SHTN1 TOX2 WNK2	1.32e-03	743	48	7	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#5	PRR36 SHTN1 TOX2 WNK2	1.33e-03	212	48	4	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K5
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_200	RBM26 KDM6B	1.45e-03	25	48	2	gudmap_developingGonad_e14.5_ epididymis_200_k3
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_500	ZFHX4 KDM6B	1.45e-03	25	48	2	gudmap_developingGonad_e11.5_testes and mesonephros_k2_500
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#4_top-relative-expression-ranked_200	ZFHX4 RBM26	1.45e-03	25	48	2	gudmap_developingGonad_e11.5_ovary + mesonephros_k4_200
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#1_top-relative-expression-ranked_1000	RBM26 SMARCC1 KDM6B	1.46e-03	99	48	3	gudmap_developingGonad_e14.5_ epididymis_1000_k1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_100	IRS4 PRR36 FEZF1	1.46e-03	99	48	3	Facebase_RNAseq_e8.5_Floor Plate_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_100	IRS4 PRR36 FEZF1	1.50e-03	100	48	3	Facebase_RNAseq_e10.5_Olfactory Pit_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000	GORASP2 IRS4 PRR36 FEZF1 FMN2 SHTN1 TOX2 WNK2	1.52e-03	986	48	8	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#5	GORASP2 IRS4 FEZF1	1.55e-03	101	48	3	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K5
CoexpressionAtlas	DevelopingGonad_e16.5_testes_emap-8444_k-means-cluster#3_top-relative-expression-ranked_1000	GORASP2 UBAP2L RBM26 FNBP4 SMN1	1.59e-03	378	48	5	gudmap_developingGonad_e16.5_testes_1000_k3
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#1_top-relative-expression-ranked_1000	RBM26 FNBP4 KDM6B	1.73e-03	105	48	3	gudmap_developingGonad_e18.5_epididymis_1000_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#1_top-relative-expression-ranked_1000	ZFHX4 FMN2 KAT6B RBM20	1.77e-03	229	48	4	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#4_top-relative-expression-ranked_200	IRS4 ZFHX4	1.82e-03	28	48	2	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k4_200
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_k-means-cluster#4_top-relative-expression-ranked_500	GORASP2 UBAP2L RBM26 SMN1	1.82e-03	231	48	4	gudmap_developingGonad_e11.5_testes and mesonephros_k4_500
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	SETD1B CHERP PRPF40B UBAP2L SMARCC1	1.08e-06	166	49	5	32d2eaf8a5d03881bf74d680825af2d5110b082d
Drug	Tiletamine hydrochloride; Down 200; 15.4uM; MCF7; HT_HG-U133A	UBAP2L WWTR1 ARHGAP35 KDM6B GRM1	5.71e-05	192	49	5	6013_DN
Drug	Indoprofen [31842-01-0]; Down 200; 14.2uM; PC3; HT_HG-U133A	RBM26 ARHGAP35 KDM6B GRM1 SF3A2	6.00e-05	194	49	5	4249_DN
Drug	Menadione [58-27-5]; Down 200; 23.2uM; PC3; HT_HG-U133A	TULP4 WWTR1 ARHGAP35 KDM6B SCAF4	6.00e-05	194	49	5	4662_DN
Drug	Pentamidine isethionate [140-64-7]; Down 200; 6.8uM; MCF7; HT_HG-U133A	ZNF747 WWTR1 KDM6B SF3A2 SCAF4	6.15e-05	195	49	5	4396_DN
Drug	Hydroflumethiazide [135-09-1]; Down 200; 12uM; PC3; HT_HG-U133A	PRR36 ZNF747 ARHGAP35 SF3A2 SCAF4	6.45e-05	197	49	5	1809_DN
Drug	Meglumine [6284-40-8]; Down 200; 20.4uM; MCF7; HT_HG-U133A	MED15 WWTR1 SF3A2 SCAF4 CPSF7	6.45e-05	197	49	5	5285_DN
Drug	Ketanserin tartrate hydrate [83846-83-7]; Up 200; 7uM; MCF7; HT_HG-U133A	MED15 SETD1B RBM26 ZNF747 GRM1	6.45e-05	197	49	5	3209_UP
Drug	AG-028671 [847803-03-6]; Down 200; 10uM; MCF7; HT_HG-U133A	PRR36 PPRC1 SF3A2 SCAF4 DHX30	6.61e-05	198	49	5	6587_DN
Drug	Dyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; HL60; HT_HG-U133A	ZNF747 MFN2 ARHGAP35 KDM6B KAT6B	6.61e-05	198	49	5	2392_DN
Drug	Flecainide acetate [54143-56-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	UBAP2L WWTR1 ARHGAP35 KDM6B SCAF4	6.61e-05	198	49	5	3418_DN
Drug	Nitrofural [59-87-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A	UBAP2L SMARCC1 WWTR1 ARHGAP35 SCAF4	6.77e-05	199	49	5	5321_DN
Drug	Zalcitabine [7481-89-2]; Down 200; 19uM; MCF7; HT_HG-U133A	PRR36 ZNF747 KAT6B SF3A2 CPSF7	6.77e-05	199	49	5	4799_DN
Drug	Clindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; MCF7; HT_HG-U133A	PDE4A LMOD1 WWTR1 ARHGAP35 KDM6B	6.77e-05	199	49	5	7172_UP
Drug	Carbamazepine [298-46-4]; Down 200; 17uM; MCF7; HT_HG-U133A	TULP4 UBAP2L WWTR1 KDM6B SF3A2	6.77e-05	199	49	5	1683_DN
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	ABI1 TULP4 PRPF40B FEZF1 UBAP2L SHTN1 SCAF4	3.37e-04	801	49	7	EFO_0003888, EFO_0007052, MONDO_0002491

Protein segments in the cluster

Peptide	Gene	Start	Entry
VQPMQPLLPQPPLPP	AMELY	161	Q99218
SIAPPPPPMPQLTPQ	ABI1	361	Q8IZP0
PPPMPQLTPQIPLTG	ABI1	366	Q8IZP0
LPPPRLPPMCVNPTP	DHX30	21	Q7L2E3
SGPRGMQQPPPPPQP	RBM20	36	Q5T481
PPPLPPLQPSGMDAP	RBM26	381	Q5T8P6
NRPPSALPLMGLPPP	CPSF7	226	Q8N684
PPNLTPPPMNLPPPL	KAT6B	1881	Q8WYB5
VAQPVPLLMTPPPPP	ESPNL	326	Q6ZVH7
LVNPGLPPLPSMPPR	GORASP2	336	Q9H8Y8
LPPLPSMPPRNLPGI	GORASP2	341	Q9H8Y8
QPLLPPPPCPAQPLG	KCNK4	301	Q9NYG8
GPMTPTQPPPPLSLP	KDM6B	891	O15054
PPPPPLAPPLIMENL	LMOD1	536	P29536
PPPPPVPHLQPMSQI	PDE4A	321	P27815
QSMPPPPQPSPQPGQ	MED15	446	Q96RN5
PIPLTPANPSMPPLP	MFN2	576	O95140
PPPVSMSPGQPPPQQ	CASC3	601	O15234
TMPPLPQPPLAPAAP	CHERP	81	Q8IWX8
MSLLTSPHQPPPPPP	FNBP1	331	Q96RU3
LPPEDLPNQPPGPMP	BCL9L	1261	Q86UU0
MLPPPPRQPPPQARA	MARVELD1	1	Q9BSK0
TPNPHMPQTPLPPRP	ITIH6	876	Q6UXX5
YPPPPPPQHLQMLPL	GRM1	1066	Q13255
PLQGTEMLPPPPPPL	FMN2	901	Q9NZ56
LPTPPFPPMAQPVIP	SCAF4	371	O95104
LGMPPSLPPPPLQPP	PPRC1	886	Q5VV67
QSKQQQMPPPPPPPP	IRS4	621	O14654
LLNPRPYLLPPMPGP	AK9	376	Q5TCS8
LPPPPQMLAPAFPPP	PRCC	51	Q92733
SLPPVPPMGLPPPQE	TBC1D25	596	Q3MII6
PVLQPPLPLEMPPPP	FNBP4	701	Q8N3X1
PQQPPMTLPPLQPPL	FEZF1	446	A0PJY2
MTLPPLQPPLPTPGP	FEZF1	451	A0PJY2
PPLQVPPSPPASLPM	PRR36	986	Q9H6K5
LPMSPLATPPPQAPP	PRR36	1041	Q9H6K5
PLPPPPPNPIRSLMS	SHTN1	361	A0MZ66
NSFLPPPPPMPGPRL	SMN1	191	Q16637
MLPLPLQPPLPPPRP	SETD1B	1316	Q9UPS6
SPPPTPQSPMQPLLP	ARHGAP35	1476	Q9NRY4
MPPPHPPQPGQIPGP	SMARCC1	1006	Q92922
KRPPPPLMNGLPPRP	SF3A2	231	Q15428
PLMNGLPPRPPLPES	SF3A2	236	Q15428
PPLSLPPPPQGPMQL	TULP4	771	Q9NRJ4
PLPPAPPQPSSMGPV	ZFHX4	1966	Q86UP3
LPPGVPPLLPNPYIM	UBAP2L	791	Q14157
PMAPPLAPLPPRDPN	ZNF747	11	Q9BV97
MALNRPQQPPPPPPP	WASF3	296	Q9UPY6
LPPMSQRPPAIPPMP	PRPF40B	21	Q6NWY9
QRPPAIPPMPPGILP	PRPF40B	26	Q6NWY9
PPVSMSPAPQPPVLP	TOX2	401	Q96NM4
PQPVLPPQPMLPPQP	WNK2	976	Q9Y3S1
PPQPMLPPQPVLPPQ	WNK2	981	Q9Y3S1
QIQAPPMPGPPPLGP	WBP11	401	Q9Y2W2
MNPASAPPPLPPPGQ	WWTR1	1	Q9GZV5
SPQLMPPDPLPPPLS	KMT2D	926	O14686