Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A GABRG1 ANO2 CLCA3P CLCA2 TRPM3 ANO5 GRIK3 TRPM1 ITPR1

2.26e-054598410GO:0005216
GeneOntologyMolecularFunctionchloride channel activity

GABRG1 ANO2 CLCA3P CLCA2 ANO5

3.11e-0586845GO:0005254
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

GABRG1 ANO2 CLCA2 ANO5

5.79e-0550844GO:0099095
GeneOntologyMolecularFunctionchannel activity

CACNA1A GABRG1 ANO2 CLCA3P CLCA2 TRPM3 ANO5 GRIK3 TRPM1 ITPR1

7.00e-055258410GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A GABRG1 ANO2 CLCA3P CLCA2 TRPM3 ANO5 GRIK3 TRPM1 ITPR1

7.11e-055268410GO:0022803
GeneOntologyMolecularFunctionmonoatomic anion channel activity

GABRG1 ANO2 CLCA3P CLCA2 ANO5

7.40e-05103845GO:0005253
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO2 CLCA2 ANO5

7.77e-0520843GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO2 CLCA2 ANO5

7.77e-0520843GO:0005229
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRG1 ANO2 CLCA2 ANO5 GRIK3 ITPR1

1.64e-04193846GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GABRG1 ANO2 CLCA2 ANO5 GRIK3 ITPR1

1.83e-04197846GO:0022834
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

GABRG1 ANO2 CLCA3P CLCA2 ANO5

1.84e-04125845GO:0015108
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CLCA3P TRPM3 TRPM1 ITPR1

2.14e-04129845GO:0005262
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGTLC2 GGT3P

2.59e-046842GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGTLC2 GGT3P

2.59e-046842GO:0002951
GeneOntologyMolecularFunctiontransporter activity

CACNA1A GABRG1 ANO2 CLCA3P PRELID1 CLCA2 TRPM3 SLC25A39 SLC6A17 SLC44A2 LRP2 ANO5 GRIK3 TRPM1 ITPR1

2.83e-0412898415GO:0005215
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GABRG1 ANO2 CLCA3P CLCA2 ANO5

4.42e-04151845GO:0008509
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A CLCA3P TRPM3 TRPM1 ITPR1

4.42e-04151845GO:0015085
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGTLC2 GGT3P

4.82e-048842GO:0103068
GeneOntologyMolecularFunctiongated channel activity

CACNA1A GABRG1 ANO2 CLCA2 ANO5 GRIK3 ITPR1

5.17e-04334847GO:0022836
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGTLC2 GGT3P

6.18e-049842GO:0036374
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GABRG1 ANO2 CLCA3P CLCA2 ANO5

7.77e-04171845GO:0015103
GeneOntologyMolecularFunctiontau protein binding

PPP2CA PPP2CB ROCK1

9.57e-0446843GO:0048156
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1A GABRG1 ANO2 CLCA3P CLCA2 TRPM3 SLC25A39 SLC6A17 SLC44A2 ANO5 GRIK3 TRPM1 ITPR1

1.25e-0311808413GO:0022857
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1A GABRG1 ANO2 CLCA3P CLCA2 TRPM3 ANO5 GRIK3 TRPM1 ITPR1

1.28e-037588410GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1A GABRG1 ANO2 CLCA3P CLCA2 TRPM3 ANO5 GRIK3 TRPM1 ITPR1

1.79e-037938410GO:0015075
GeneOntologyMolecularFunctionomega peptidase activity

GGTLC2 GGT3P

2.02e-0316842GO:0008242
GeneOntologyMolecularFunctionoxidoreductase activity, acting on metal ions

HEPHL1 MMACHC

2.56e-0318842GO:0016722
GeneOntologyMolecularFunctionthreonine-type peptidase activity

GGTLC2 GGT3P

3.16e-0320842GO:0070003
GeneOntologyMolecularFunctionGABA receptor binding

GABRG1 PPP2CA

3.16e-0320842GO:0050811
GeneOntologyMolecularFunctioncatalytic activity, acting on a tRNA

IARS1 GGTLC2 TRMT5 GGT3P

3.20e-03144844GO:0140101
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A CLCA3P TRPM3 GRIK3 TRPM1 ITPR1

3.25e-03343846GO:0005261
GeneOntologyMolecularFunctionphospholipid transporter activity

ANO2 PRELID1 ANO5

3.75e-0374843GO:0005548
GeneOntologyMolecularFunctioncatalytic activity, acting on a glycoprotein

C1GALT1C1 MGAT4B

4.18e-0323842GO:0140103
GeneOntologyMolecularFunctionphospholipid scramblase activity

ANO2 ANO5

4.18e-0323842GO:0017128
GeneOntologyCellularComponentphosphatase complex

PPP1R10 PPP2CA PPP2CB ITPR1

7.76e-0555864GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP1R10 PPP2CA PPP2CB ITPR1

7.76e-0555864GO:0008287
DomainTF_fork_head_CS_2

FOXD2 FOXD3 FOXD4L1 FOXD4

4.66e-0546814IPR030456
DomainTF_fork_head_CS_1

FOXD2 FOXD3 FOXD4L1 FOXD4

5.08e-0547814IPR018122
DomainFH

FOXD2 FOXD3 FOXD4L1 FOXD4

6.00e-0549814SM00339
DomainFORK_HEAD_1

FOXD2 FOXD3 FOXD4L1 FOXD4

6.00e-0549814PS00657
DomainFORK_HEAD_2

FOXD2 FOXD3 FOXD4L1 FOXD4

6.00e-0549814PS00658
DomainFork_head_dom

FOXD2 FOXD3 FOXD4L1 FOXD4

6.00e-0549814IPR001766
DomainFORK_HEAD_3

FOXD2 FOXD3 FOXD4L1 FOXD4

6.00e-0549814PS50039
DomainForkhead

FOXD2 FOXD3 FOXD4L1 FOXD4

6.00e-0549814PF00250
DomainTRPM_tetra

TRPM3 TRPM1

1.11e-044812IPR032415
DomainTRPM_tetra

TRPM3 TRPM1

1.11e-044812PF16519
DomainFerI

OTOF FER1L5

1.84e-045812SM01202
DomainFerB

OTOF FER1L5

1.84e-045812SM01201
DomainFerlin_B-domain

OTOF FER1L5

1.84e-045812IPR012561
DomainFerlin_C

OTOF FER1L5

1.84e-045812PF16165
DomainFerlin_C

OTOF FER1L5

1.84e-045812IPR032362
DomainFerIin_dom

OTOF FER1L5

1.84e-045812IPR012968
DomainFerI

OTOF FER1L5

1.84e-045812PF08151
DomainFerB

OTOF FER1L5

1.84e-045812PF08150
DomainGGT_peptidase

GGTLC2 GGT3P

3.85e-047812IPR000101
DomainAnoct_dimer

ANO2 ANO5

3.85e-047812PF16178
DomainG_GLU_TRANSPEPTIDASE

GGTLC2 GGT3P

3.85e-047812PS00462
DomainAnoct_dimer

ANO2 ANO5

3.85e-047812IPR032394
DomainG_glu_transpept

GGTLC2 GGT3P

3.85e-047812PF01019
DomainAnoctamin

ANO2 ANO5

8.17e-0410812PF04547
DomainAnoctamin

ANO2 ANO5

8.17e-0410812IPR007632
DomainSer/Thr-sp_prot-phosphatase

PPP2CA PPP2CB

1.40e-0313812IPR006186
DomainSER_THR_PHOSPHATASE

PPP2CA PPP2CB

1.40e-0313812PS00125
DomainPP2Ac

PPP2CA PPP2CB

1.40e-0313812SM00156
DomainIon_trans_dom

CACNA1A TRPM3 TRPM1 ITPR1

1.53e-03114814IPR005821
DomainIon_trans

CACNA1A TRPM3 TRPM1 ITPR1

1.53e-03114814PF00520
DomainGal_mutarotase_SF_dom

MAN2A2 GANC

2.42e-0317812IPR011013
DomainC2

OTOF SYTL4 UNC13C FER1L5

2.53e-03131814PF00168
DomainZF_DAG_PE_1

ARHGEF28 ROCK1 UNC13C

2.71e-0364813PS00479
DomainZF_DAG_PE_2

ARHGEF28 ROCK1 UNC13C

2.71e-0364813PS50081
DomainC1

ARHGEF28 ROCK1 UNC13C

2.83e-0365813SM00109
DomainPE/DAG-bd

ARHGEF28 ROCK1 UNC13C

2.95e-0366813IPR002219
DomainC2

OTOF SYTL4 UNC13C FER1L5

2.98e-03137814SM00239
DomainC2

OTOF SYTL4 UNC13C FER1L5

3.39e-03142814PS50004
Domain-

OTOF SYTL4 UNC13C FER1L5

3.93e-031488142.60.40.150
DomainC2_dom

OTOF SYTL4 UNC13C FER1L5

5.64e-03164814IPR000008
DomainCalcineurin-like_PHP_ApaH

PPP2CA PPP2CB

6.53e-0328812IPR004843
DomainRICIN

GALNT11 LY75

6.53e-0328812SM00458
DomainMetallophos

PPP2CA PPP2CB

6.53e-0328812PF00149
DomainRICIN_B_LECTIN

GALNT11 LY75

6.53e-0328812PS50231
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO2 CLCA2 TRPM3 ANO5 TRPM1

7.27e-0599625MM14910
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO2 CLCA2 TRPM3 ANO5 TRPM1

1.01e-04106625M27200
PathwayKEGG_LONG_TERM_DEPRESSION

CACNA1A PPP2CA PPP2CB ITPR1

2.50e-0470624M8232
PathwayREACTOME_LATE_SARS_COV_2_INFECTION_EVENTS

ANO2 MGAT4B ANO5 ST3GAL2

2.50e-0470624M46438
PathwayKEGG_O_GLYCAN_BIOSYNTHESIS

C1GALT1C1 GALNT11 ST3GAL2

3.02e-0430623M6929
Pubmed

An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.

FOXD2 FOXD3 FOXD4L1 FOXD4

4.35e-09986412412011
Pubmed

Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.

MGAT4B MAN2A2 GANC ST3GAL2

2.16e-06378642541446
Pubmed

Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.

MGAT4B MAN2A2 GANC ST3GAL2

2.16e-06378642542563
Pubmed

Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.

MGAT4B MAN2A2 GANC ST3GAL2

2.41e-06388642829950
Pubmed

Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.

MGAT4B MAN2A2 GANC ST3GAL2

2.41e-06388642187500
Pubmed

Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.

MGAT4B MAN2A2 GANC ST3GAL2

5.25e-06468642649653
Pubmed

Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.

TRPM3 TRPM1

6.04e-06286221278253
Pubmed

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PPP2CA PPP2CB

6.04e-0628622555176
Pubmed

Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation.

PPP2CA DCK

6.04e-06286224462681
Pubmed

Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells.

ENPP2 MMP3

6.04e-06286219212832
Pubmed

Clinical and genetic findings in a cohort of Chinese patients with autosomal recessive spinocerebellar ataxia.

SETX ENPP2

6.04e-06286231743419
Pubmed

The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.

PPP2CA PPP2CB

6.04e-06286210543450
Pubmed

Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.

PPP2CA PPP2CB

6.04e-06286211751260
Pubmed

Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31).

CLCA3P CLCA2

6.04e-06286210584316
Pubmed

Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.

PPP2CA PPP2CB

6.04e-06286234902541
Pubmed

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PPP2CA PPP2CB

6.04e-0628622837763
Pubmed

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PPP2CA PPP2CB

6.04e-0628621846293
Pubmed

The promoter methylations of the autoimmune regulator (AIRE) gene and matrix metalloproteinase-3 (MMP-3) gene may have a role in gestational diabetes mellitus.

AIRE MMP3

6.04e-06286236808352
Pubmed

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

PPP2CA PPP2CB

6.04e-06286227096707
Pubmed

Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.

PPP2CA PPP2CB

6.04e-06286211113010
Pubmed

Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.

GCM2 AIRE LY75

7.99e-061686325053428
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXD3 FOXD4L1 FOXD4

7.99e-061686310208738
Pubmed

Integral and associated lysosomal membrane proteins.

GPLD1 DNAJC13 SLC44A2 LRP2 SPG11

1.59e-0512686517897319
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A UNC13C

1.81e-05386229466725
Pubmed

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PPP2CA PPP2CB

1.81e-0538628206937
Pubmed

Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling.

CACNA1A ITPR1

1.81e-05386214570872
Pubmed

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

PPP2CA PPP2CB

1.81e-0538627510677
Pubmed

Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.

CLCA2 LY75

1.81e-05386225557950
Pubmed

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.

PPP2CA PPP2CB

1.81e-05386210441131
Pubmed

Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.

PPP2CA PPP2CB

1.81e-05386223341017
Pubmed

Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.

PPP2CA PPP2CB

1.81e-0538628383590
Pubmed

Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.

PPP2CA PPP2CB

1.81e-05386215252037
Pubmed

Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.

MGAT4B MAN2A2 GANC

2.17e-05228638673525
Pubmed

Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.

MGAT4B MAN2A2 GANC

2.17e-05228639109416
Pubmed

Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.

MGAT4B MAN2A2 GANC

2.17e-052286311530211
Pubmed

Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.

MGAT4B MAN2A2 GANC

2.49e-05238631736542
Pubmed

Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.

MGAT4B MAN2A2 GANC

2.49e-05238638093218
Pubmed

Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.

MGAT4B MAN2A2 GANC

2.49e-05238633099781
Pubmed

Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.

MGAT4B MAN2A2 GANC

2.49e-05238633264072
Pubmed

Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4.

PPP2CA PPP2CB

3.61e-05486211371618
Pubmed

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

PPP2CA PPP2CB

3.61e-05486221454489
Pubmed

Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.

TRPM3 TRPM1

3.61e-05486222211741
Pubmed

The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.

PPP2CA PPP2CB

3.61e-05486214633983
Pubmed

Molecular characteristics and functional diversity of CLCA family members.

CLCA3P CLCA2

3.61e-05486211071307
Pubmed

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.

PPP2CA PPP2CB

3.61e-05486221998041
Pubmed

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.

PPP2CA PPP2CB

3.61e-0548629770493
Pubmed

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

PPP2CA PPP2CB

3.61e-0548627616230
Pubmed

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PPP2CA PPP2CB

3.61e-0548629920888
Pubmed

Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.

RASGRF2 MMP3

3.61e-05486223145787
Pubmed

Lung lining fluid glutathione attenuates IL-13-induced asthma.

GGTLC2 GGT3P

6.01e-05586218063838
Pubmed

Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

GGTLC2 GGT3P

6.01e-05586210940879
Pubmed

Cataract development in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGT3P

6.01e-05586211095909
Pubmed

Expression of gamma-glutamyl transpeptidase in midgestation mouse yolk sac and mouse visceral yolk sac carcinoma cells.

GGTLC2 GGT3P

6.01e-0558627641802
Pubmed

Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.

GGTLC2 GGT3P

6.01e-05586223615310
Pubmed

The mouse skin carcinogenesis model.

GGTLC2 GGT3P

6.01e-0558629627710
Pubmed

Gamma-glutamyl transpeptidase and its role in melanogenesis: redox reactions and regulation of tyrosinase.

GGTLC2 GGT3P

6.01e-05586212453183
Pubmed

gamma-glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial function, and cellular function.

GGTLC2 GGT3P

6.01e-05586211003618
Pubmed

Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain.

PPP2CA PPP2CB

6.01e-05586210640627
Pubmed

Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species.

GGTLC2 GGT3P

6.01e-05586210392451
Pubmed

Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney.

GGTLC2 GGT3P

6.01e-0558622891746
Pubmed

Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress.

GGTLC2 GGT3P

6.01e-05586219850887
Pubmed

Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGT3P

6.01e-05586212810527
Pubmed

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGT3P

6.01e-0558628755578
Pubmed

Reproductive defects in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGT3P

6.01e-05586211089562
Pubmed

Liver-Specific Overexpression of Gamma-Glutamyltransferase Ameliorates Insulin Sensitivity of Male C57BL/6 Mice.

GGTLC2 GGT3P

6.01e-05586228660214
Pubmed

Bleomycin-induced pulmonary fibrosis is attenuated in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGT3P

6.01e-05586212468440
Pubmed

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

GGTLC2 GGT3P

6.01e-05586226977590
Pubmed

Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia.

GGTLC2 GGT3P

6.01e-05586212225953
Pubmed

Identification of a sixth promoter that directs the transcription of gamma-glutamyl transpeptidase type III RNA in mouse.

GGTLC2 GGT3P

6.01e-0558627775425
Pubmed

Cloning of cDNA and genomic structure of the mouse gamma-glutamyl transpeptidase-encoding gene.

GGTLC2 GGT3P

6.01e-0558628566783
Pubmed

Therapeutic Effect of GGsTop, Selective Gamma-glutamyl Transpeptidase Inhibitor, on a Mouse Model of 5-Fluorouracil-induced Oral Mucositis.

GGTLC2 GGT3P

6.01e-05586230591459
Pubmed

Mice with genetic gamma-glutamyl transpeptidase deficiency exhibit glutathionuria, severe growth failure, reduced life spans, and infertility.

GGTLC2 GGT3P

6.01e-0558629139708
Pubmed

Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue.

GGTLC2 GGT3P

6.01e-05586220622017
Pubmed

Accelerated methylmercury elimination in gamma-glutamyl transpeptidase-deficient mice.

GGTLC2 GGT3P

6.01e-0558629546365
Pubmed

In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knockout mice.

GGTLC2 GGT3P

6.01e-05586211795900
Pubmed

gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?

GGTLC2 GGT3P

6.01e-0558627485380
Pubmed

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.

PPP2CA PPP2CB

6.01e-0558629009195
Pubmed

Protein phosphatase 2A interacts with and directly dephosphorylates RelA.

PPP2CA PPP2CB

6.01e-05586211591705
Pubmed

Accumulation of DNA damage in the organs of mice deficient in gamma-glutamyltranspeptidase.

GGTLC2 GGT3P

6.01e-05586210751614
Pubmed

Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the mouse small intestine.

GGTLC2 GGT3P

6.01e-0558627523374
Pubmed

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

PPP2CA PPP2CB

6.01e-05586218596935
Pubmed

Cardio-reno-hepatic interactions in acute heart failure: the role of γ-glutamyl transferase.

GGTLC2 GGT3P

6.01e-05586224698228
Pubmed

Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma.

GGTLC2 GGT3P

6.01e-05586225132819
Pubmed

Characterization of the dwg mutations: dwg and dwg(Bayer) are new mutant alleles of the Ggt1 gene.

GGTLC2 GGT3P

6.01e-05586219760322
Pubmed

gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA.

GGTLC2 GGT3P

6.01e-05586210474818
Pubmed

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.

PPP1R10 PPP2CB DNAJC13 GRAMD4

7.25e-058986427034005
Pubmed

Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development.

PPP2CA PPP2CB

9.01e-05686210781942
Pubmed

Gamma-glutamyltranspeptidase stimulates receptor activator of nuclear factor-kappaB ligand expression independent of its enzymatic activity and serves as a pathological bone-resorbing factor.

GGTLC2 GGT3P

9.01e-05686214634009
Pubmed

Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.

PPP2CA PPP2CB

9.01e-05686220100830
Pubmed

Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.

PPP2CA PPP2CB

9.01e-05686229735529
Pubmed

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

FOXD4L1 FOXD4

9.01e-05686227092474
Pubmed

Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosis.

GGTLC2 GGT3P

9.01e-05686217363454
Pubmed

Six mRNAs with different 5' ends are encoded by a single gamma-glutamyltransferase gene in mouse.

GGTLC2 GGT3P

9.01e-0568628101000
Pubmed

Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase.

GGTLC2 GGT3P

9.01e-0568628663190
Pubmed

Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes.

GGTLC2 GGT3P

9.01e-0568628104871
Pubmed

Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response.

GGTLC2 GGT3P

9.01e-05686211463821
Pubmed

Protein phosphorylation of human brain glutamic acid decarboxylase (GAD)65 and GAD67 and its physiological implications.

PPP2CA PPP2CB

9.01e-05686215147202
Pubmed

Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice.

GGTLC2 GGT3P

9.01e-05686225326709
Pubmed

STRIPAK components determine mode of cancer cell migration and metastasis.

PPP2CA PPP2CB

9.01e-05686225531779
Pubmed

Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.

GGTLC2 GGT3P

9.01e-05686212163373
InteractionFOXD4 interactions

FOXD2 PPP2CA PPP2CB FOXD4L1 FOXD4

3.50e-0657825int:FOXD4
GeneFamilyChloride channel accessory

CLCA3P CLCA2

6.04e-054582867
GeneFamilyFerlin family

OTOF FER1L5

1.50e-046582828
GeneFamilyForkhead boxes

FOXD2 FOXD3 FOXD4

3.53e-0443583508
GeneFamilyAnoctamins

ANO2 ANO5

4.48e-0410582865
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP2CA PPP2CB

7.71e-0413582693
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGTLC2 GGT3P

7.71e-0413582564
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

PPP2CA PPP2CB

1.85e-03205821371
GeneFamilyTransient receptor potential cation channels

TRPM3 TRPM1

3.62e-0328582249
GeneFamilySerpin peptidase inhibitors

SERPINA4 SERPINA12

6.27e-0337582739
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 TENM4 TRPM3 SLC6A17 LRP2 ANO5 UNC13C GRIK3

2.71e-091848682cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 TENM4 TRPM3 SLC6A17 LRP2 ANO5 UNC13C GRIK3

2.71e-09184868ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO2 TENM4 TRPM3 SLC6A17 LRP2 ANO5 UNC13C GRIK3

2.71e-091848682b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Kidney-nan-18m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENBP1 GALNT11 SLC25A39 ENPP2 LRP2 ITPR1

1.70e-06187866236e9857729670e87eed30fad58f49e1f56e4a85
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Efna5|Hippocampus / BrainAtlas - Mouse McCarroll V32

XKR7 SYTL4 STAG3 SERPINA12

5.23e-065986452cf452beca2fc91f131997610228a1b04a7f5df
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Efna5-Inhibitory_Gad1Gad2_Htr3a.Efba5_(Interneuron,__(candidate_CGE-derived_4))|Hippocampus / BrainAtlas - Mouse McCarroll V32

XKR7 SYTL4 STAG3 SERPINA12

5.23e-0659864e85f816cbebe7efe99d368cf5c01e68b39e231ac
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Efna5-Inhibitory_Gad1Gad2_Htr3a.Efba5_(Interneuron,__(candidate_CGE-derived_4))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

XKR7 SYTL4 STAG3 SERPINA12

5.23e-065986418cb0aaa7c0652721b4004a042cbc8ff4328a065
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1A SERPINA4 XKR7 TRPM3 LRP2

7.46e-06139865a1945b07f177cde40e7eea03a19236ce76165857
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ARHGEF28 PTPRK RASGRF2 OTOF ENPP2

1.30e-051568652cd007b423c2395c5ce331902e7f27c805755eb3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TENM4 TRPM3 LRP2 GGTLC2 GRAMD4

3.04e-05186865b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

ANO2 ARHGEF28 RASGRF2 ENPP2 GMDS

3.12e-0518786540ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

ANO2 RASGRF2 TRPM3 GMDS ITPR1

3.28e-05189865c81787a8c662db5d7814c583dd64562857629e81
ToppCelltumor_Lung-B_lymphocytes-GC_B_cells_in_the_LZ|B_lymphocytes / Location, Cell class and cell subclass

PPP2CA SYTL4 GMDS STAG3 FERMT3

3.36e-05190865bfb16efb23add53eebabc8e48f20c96994ec01da
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A TENM4 RASGRF2 OTOF SLC6A17

3.62e-05193865be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A TENM4 RASGRF2 OTOF SLC6A17

3.62e-051938650c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A TENM4 RASGRF2 OTOF SLC6A17

3.62e-051938658689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC|Multiple_Sclerosis / Disease, condition lineage and cell class

CACNA1A RHBDL2 MAN2A2 MORN1 SNX25

4.29e-05200865ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
Diseaseamino acid measurement

FOXD2 GABRG1 ANO2 SETX GCFC2 ARHGEF28 TENM4 RABGAP1L MCM9 LRP2 UNC13C

2.45e-066788111EFO_0005134
Diseasevaspin measurement

SERPINA4 SERPINA12

7.44e-062812EFO_0004915
Diseaselevel of serpin A12 in blood serum

SERPINA4 SERPINA12

7.44e-062812OBA_2045007
Diseaseserpin A12 measurement

SERPINA4 SERPINA12

7.40e-055812EFO_0802061
Diseaselimb-girdle muscular dystrophy (implicated_via_orthology)

OTOF FER1L5

1.55e-047812DOID:11724 (implicated_via_orthology)
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGTLC2 GGT3P

1.55e-047812DOID:5022 (biomarker_via_orthology)
DiseaseMASA syndrome (implicated_via_orthology)

TRPM3 TRPM1

1.55e-047812DOID:0060246 (implicated_via_orthology)
Diseasealcohol dependence (biomarker_via_orthology)

GGTLC2 GGT3P

2.06e-048812DOID:0050741 (biomarker_via_orthology)
Diseasekallistatin measurement

SERPINA4 SERPINA12

2.06e-048812EFO_0008196
DiseaseProteinuria

LRP2 UNC13C

7.64e-0415812HP_0000093
Diseaselateral ventricle volume change measurement

SERPINA4 SERPINA12

7.64e-0415812EFO_0021502
Diseasecolorectal mucinous adenocarcinoma

RASGRF2 TRPM1

8.71e-0416812EFO_0009361
DiseaseAmyotrophic lateral sclerosis

SETX SPG11

9.85e-0417812cv:C0002736
Diseaseprotein Z-dependent protease inhibitor measurement

SERPINA4 SERPINA12

1.11e-0318812EFO_0021849
Diseaseglaucoma (is_marker_for)

FOXD3 SELENBP1

1.37e-0320812DOID:1686 (is_marker_for)
Diseaseisthmus cingulate cortex volume measurement

GCFC2 TENM4

2.32e-0326812EFO_0010310
DiseasePsychotic Disorders

TENM4 SELENBP1 GRIK3

2.74e-03101813C0033975

Protein segments in the cluster

PeptideGeneStartEntry
PEWLSDFLYYAEFIF

CACNA1A

511

O00555
WLYKFSADEFFIPRE

ZBTB8OS

96

Q8IWT0
NWARFSYFYKEQPLD

ANO5

276

Q75V66
LTIFVARLYYFWDPD

APOBEC3G

116

Q9HC16
LQKWFYERFGEYVED

GRAMD4

166

Q6IC98
VFLPFTWVEKYFDVY

GLCE

126

O94923
EWARYGVFYKFQPID

ANO2

336

Q9NQ90
NPYEFSKQYWFILSA

ANO2

891

Q9NQ90
DKYRDQYNWFFLARP

C1GALT1C1

131

Q96EU7
DFWRVLFKDYNLERY

AIRE

76

O43918
YFWDRAFLVKAFEPE

ARHGEF28

271

Q8N1W1
VYPNSFFRYEGEWKA

MORN1

31

Q5T089
YNLWFGYDVKRAVEE

GGT3P

486

A6NGU5
AAKLYAYWIVVNFRE

GMDS

181

O60547
EKAYLREDFFWAFTP

MGAT4B

416

Q9UQ53
NEGSWFYIQPFYKLR

ITPR1

156

Q14643
YFFVEDKYWRFDEKR

MMP3

401

P08254
SYARPLKFWERDYNT

PCNX3

1301

Q9H6A9
WLDEYKEQYFSLRPD

GALNT11

406

Q8NCW6
VREWYSSLFAFPVYQ

GANC

486

Q8TET4
WAKVLYLDAVEYFPD

NRDE2

1121

Q9H7Z3
WHFYDDREFIYLRPF

LY75

766

O60449
YNLWFGYDVKRAVEE

GGTLC2

136

Q14390
VVDPKNRYLFWADYG

LRP2

2196

P98164
NVWKYFTDLFDYLPL

PPP2CB

141

P62714
NVWKYFTDLFDYLPL

PPP2CA

141

P67775
DRFPYYRRKFPAWQN

FOXD4

136

Q12950
FEVYPFQVAWYNELL

MMACHC

21

Q9Y4U1
VYPANERFWYFSRKT

RABGAP1L

416

Q5R372
FKTYAPVAFRYFWEL

PIPSL

86

A2A3N6
QTWARYFVKFLDAYA

GBA

246

P04062
YSFLPYQLIAEFAWD

BFAR

336

Q9NZS9
QWREKFPDSYYEAFI

GCFC2

476

P16383
EVADPKYWRLYQFAF

GABRG1

226

Q8N1C3
DAQWLYEAAPEYFRR

DHX33

686

Q9H6R0
WFYFEAKWQFYLEER

ADPRHL1

221

Q8NDY3
RIKIEANWDLFYYRF

DNAJC13

751

O75165
RYFIAAEKILWDYAP

HEPHL1

381

Q6MZM0
DFRYDKPQEWDAQFF

MAN2A2

426

P49641
FPYYRRKFPAWQNSI

FOXD4L1

141

Q9NU39
AFASYYWALRKPDDL

SLC44A2

471

Q8IWA5
YEKPERWSFTFQTYA

DCK

86

P27707
FVIARFSPYEWYDAH

GRIK3

581

Q13003
YPAFKRVWNYFQRVL

ENPP2

706

Q13822
ISNRFPYYREKFPAW

FOXD3

171

Q9UJU5
WRYLFPFDYLAAEEK

OTOF

1791

Q9HC10
LPNTVKDFWRLVYDY

PTPRK

1251

Q15262
FPYYREKFPAWQNSI

FOXD2

161

O60548
FWEYYKSDPFAGRNV

MCM9

291

Q9NXL9
GDWFYDQKVNRFAYR

SYTL4

116

Q96C24
NPIIYVFSYQWFRKA

TAAR5

301

O14804
TYEFDFSKVYWNPRL

TRMT5

271

Q32P41
AELAVFIYYAVWKPQ

RHBDL2

81

Q9NX52
PVQNFCYIFWKRYRF

FER1L5

1946

A0AVI2
ENRFIQYFYNPTFEW

LMBRD2

361

Q68DH5
VYYINIFRDAFWPNG

SNX25

736

Q9H3E2
EKWFALYQNVLFYFE

RASGRF2

41

O14827
NYIYFKALWEKPFIS

SERPINA4

211

P29622
NPKRAVFYAERYETW

NBEA

2351

Q8NFP9
DQFREWPDGYVRFIY

GCM2

36

O75603
DQVFAAFWQRYPNPY

PRELID1

16

Q9Y255
QVRKFPADYIKYWEF

SETX

1776

Q7Z333
PADYIKYWEFAVYLE

SETX

1781

Q7Z333
IYNPAFFKYIHDRWT

ST3GAL2

256

Q16842
YSAWDKQFYPDLIRE

SELENBP1

406

Q13228
WIDFDNDYKTLYPQF

IARS1

141

P41252
NYIFFRARWKHEFDP

SERPINA12

206

Q8IW75
WGVFDEYNNDKPFYI

CLCA2

171

Q9UQC9
RWGVFDEYNVDQPFY

CLCA3P

161

Q9Y6N3
QSFPRYWIKEQDFFK

SPG11

811

Q96JI7
LTAYIRFFKENWPQY

UBTFL6

111

P0CB48
LLSFRWFVYDYSEPA

XKR7

106

Q5GH72
WFYNEYVRELPAFKD

UNC13C

1666

Q8NB66
EFLYWKLFYPECEIR

STAG3

446

Q9UJ98
DVPFSALYWFNYELV

SLC25A39

226

Q9BZJ4
KIYEFYNAPIVKFWF

TRPM3

886

Q9HCF6
FEFNFNYLARRWYVP

GPLD1

171

P80108
LFRKWFAAAPDLSYY

TENM4

1101

Q6N022
FAAAPDLSYYFIWDK

TENM4

1106

Q6N022
WYFRINYRQFFTAPA

TMUB2

286

Q71RG4
ALWLRFKYYSFFDLD

FERMT3

246

Q86UX7
FYWYRQILGQKVEFL

TRBV2

51

A0A1B0GX68
FLFWYVQYLNKEPEL

TRAV18

51

A0A075B6X5
SNYDVPEKWARFYTA

ROCK1

166

Q13464
LNALFDFWRYFKYTV

TMEM209

76

Q96SK2
LFWYRIRPDYSFQFV

TRDV3

51

A0JD37
CEFYNAPIVKFWFYT

TRPM1

821

Q7Z4N2
WIKEEAAERYLYFPN

SLC6A17

601

Q9H1V8
YQEFAKRLWGDIYFN

EFTUD2

336

Q15029
WPEEGKLREYFYFEL

PPP1R10

401

Q96QC0