Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

RAD51B KATNAL2 ABCA13 ATAD5 SEPTIN9 DNAH2 CHD4 CHD1L ARHGAP35 ARHGAP5 KIF9 ARL5B KIF2B RHOBTB2 ATP1A4 SEPTIN10 DNAH8 SNRNP200 DNAH11

9.34e-0777513319GO:0017111
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

IPO5 ARHGEF19 STXBP5L GPS1 ARHGEF38 PLCD4 ALS2 SRGAP2 SIRPB1 SIRPA ARHGAP35 ARHGAP22 ARHGAP5 RASGRP1 DOCK6

1.49e-0650713315GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

IPO5 ARHGEF19 STXBP5L GPS1 ARHGEF38 PLCD4 ALS2 SRGAP2 SIRPB1 SIRPA ARHGAP35 ARHGAP22 ARHGAP5 RASGRP1 DOCK6

1.49e-0650713315GO:0030695
GeneOntologyMolecularFunctionpyrophosphatase activity

RAD51B KATNAL2 ABCA13 ATAD5 SEPTIN9 DNAH2 CHD4 CHD1L ARHGAP35 ARHGAP5 KIF9 ARL5B KIF2B RHOBTB2 ATP1A4 SEPTIN10 DNAH8 SNRNP200 DNAH11

3.00e-0683913319GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

RAD51B KATNAL2 ABCA13 ATAD5 SEPTIN9 DNAH2 CHD4 CHD1L ARHGAP35 ARHGAP5 KIF9 ARL5B KIF2B RHOBTB2 ATP1A4 SEPTIN10 DNAH8 SNRNP200 DNAH11

3.05e-0684013319GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

RAD51B KATNAL2 ABCA13 ATAD5 SEPTIN9 DNAH2 CHD4 CHD1L ARHGAP35 ARHGAP5 KIF9 ARL5B KIF2B RHOBTB2 ATP1A4 SEPTIN10 DNAH8 SNRNP200 DNAH11

3.05e-0684013319GO:0016818
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH2 DNAH17 DNAH8 DNAH11

5.35e-06181334GO:0008569
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH2 KIF9 KIF2B DNAH17 DNAH8 DNAH11

7.21e-06701336GO:0003777
GeneOntologyMolecularFunctionATP hydrolysis activity

RAD51B KATNAL2 ABCA13 ATAD5 DNAH2 CHD4 CHD1L KIF9 KIF2B ATP1A4 DNAH8 SNRNP200 DNAH11

8.06e-0644113313GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

RAD51B KATNAL2 ABCA13 ATAD5 DNAH2 CHD4 CHD1L MSH3 KIF9 KIF2B DNAH17 ATP1A4 DNAH8 SNRNP200 DNAH11

1.49e-0561413315GO:0140657
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH2 DNAH17 DNAH8 DNAH11

3.40e-05281334GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH2 DNAH17 DNAH8 DNAH11

1.05e-04371334GO:0045505
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH2 KIF9 KIF2B DNAH17 DNAH8 DNAH11

1.40e-041181336GO:0003774
GeneOntologyMolecularFunctionenzyme regulator activity

IPO5 ARHGEF19 STXBP5L CIP2A GPS1 ARHGEF38 PPP2R3B PLCD4 RICTOR ALS2 SRGAP2 SIRPB1 SIRPA ARHGAP35 ELFN2 ARHGAP22 ARHGAP5 NCOR1 RASGRP1 C4A C4B DOCK6

1.67e-04141813322GO:0030234
GeneOntologyMolecularFunctionprotein binding involved in heterotypic cell-cell adhesion

DSG2 SIRPB1 SIRPA

2.19e-04181333GO:0086080
GeneOntologyMolecularFunctionnuclear import signal receptor activity

IPO5 RANBP6 IPO11

3.03e-04201333GO:0061608
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

IPO5 RANBP6 IPO11

1.24e-03321333GO:0140142
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

RAD51B ATAD5 CHD4 CHD1L MSH3

1.62e-031271335GO:0008094
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

1.91e-03101332GO:0001849
GeneOntologyCellularComponentmicrotubule associated complex

KATNAL2 DNAH2 HAUS3 AURKC KIF9 KIF2B DNAH17 DNAH8 DNAH11

9.18e-071611339GO:0005875
GeneOntologyCellularComponentasymmetric synapse

EPS8 ALS2 CHD4 SRGAP2 GRIN1 ELFN2 FAM81A HNRNPH1 HNRNPH2 PRICKLE2 PAK3 GSG1L

5.49e-0547713312GO:0032279
GeneOntologyCellularComponentpostsynaptic specialization

EPS8 ALS2 SRGAP2 GRIN1 ELFN2 FAM81A HNRNPH1 HNRNPH2 SLC12A5 PRICKLE2 PAK3 GSG1L

9.09e-0550313312GO:0099572
GeneOntologyCellularComponentneuron to neuron synapse

EPS8 ALS2 CHD4 SRGAP2 GRIN1 ELFN2 FAM81A HNRNPH1 HNRNPH2 PRICKLE2 PAK3 GSG1L

1.31e-0452313312GO:0098984
GeneOntologyCellularComponent9+2 motile cilium

SPEF2 DNAH2 KIF9 DNAH17 ATP1A4 SEPTIN10 DNAH8 DNAH11

1.45e-042381338GO:0097729
GeneOntologyCellularComponentpostsynaptic density

EPS8 ALS2 SRGAP2 GRIN1 ELFN2 FAM81A HNRNPH1 HNRNPH2 PRICKLE2 PAK3 GSG1L

1.49e-0445113311GO:0014069
GeneOntologyCellularComponentdynein complex

DNAH2 DNAH17 DNAH8 DNAH11

3.87e-04541334GO:0030286
GeneOntologyCellularComponentsperm flagellum

SPEF2 DNAH2 KIF9 DNAH17 ATP1A4 SEPTIN10 DNAH8

4.47e-042141337GO:0036126
GeneOntologyCellularComponentaxonemal dynein complex

DNAH2 DNAH17 DNAH8

5.23e-04251333GO:0005858
GeneOntologyCellularComponentsymbiont cell surface

C4A C4B

1.10e-0381332GO:0106139
GeneOntologyCellularComponentother organism part

C4A C4B

1.40e-0391332GO:0044217
GeneOntologyCellularComponentNMDA selective glutamate receptor complex

EPS8 GRIN1

1.40e-0391332GO:0017146
DomainP-loop_NTPase

RAD51B KATNAL2 ABCA13 ATAD5 SEPTIN9 SPEF2 DNAH2 CHD4 CHD1L MSH3 ARHGAP35 ARHGAP5 KIF9 ARL5B KIF2B N4BP2 RHOBTB2 SEPTIN10 DNAH8 SNRNP200 DNAH11

3.96e-0784813021IPR027417
Domain-

RAD51B KATNAL2 ABCA13 ATAD5 SEPTIN9 SPEF2 DNAH2 CHD4 CHD1L MSH3 ARHGAP35 ARHGAP5 ARL5B N4BP2 RHOBTB2 SEPTIN10 DNAH8 SNRNP200 DNAH11

9.95e-07746130193.40.50.300
DomainAAA

RAD51B KATNAL2 ABCA13 ATAD5 DNAH2 DNAH8 SNRNP200 DNAH11

7.56e-061441308SM00382
DomainAAA+_ATPase

RAD51B KATNAL2 ABCA13 ATAD5 DNAH2 DNAH8 SNRNP200 DNAH11

7.56e-061441308IPR003593
DomainDHC_N1

DNAH2 DNAH8 DNAH11

1.80e-0581303PF08385
DomainDynein_heavy_dom-1

DNAH2 DNAH8 DNAH11

1.80e-0581303IPR013594
DomainRhoGAP-FF1

ARHGAP35 ARHGAP5

4.81e-0521302PF16512
DomainRhoGAP-FF1

ARHGAP35 ARHGAP5

4.81e-0521302IPR032835
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH8 DNAH11

1.13e-04141303IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH8 DNAH11

1.13e-04141303IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH8 DNAH11

1.13e-04141303IPR013602
DomainDHC_N2

DNAH2 DNAH8 DNAH11

1.13e-04141303PF08393
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH8 DNAH11

1.13e-04141303IPR011704
DomainMT

DNAH2 DNAH8 DNAH11

1.13e-04141303PF12777
DomainAAA_8

DNAH2 DNAH8 DNAH11

1.13e-04141303PF12780
DomainAAA_5

DNAH2 DNAH8 DNAH11

1.13e-04141303PF07728
DomainDHC_fam

DNAH2 DNAH8 DNAH11

1.41e-04151303IPR026983
DomainDynein_heavy

DNAH2 DNAH8 DNAH11

1.41e-04151303PF03028
DomainDynein_heavy_dom

DNAH2 DNAH8 DNAH11

1.41e-04151303IPR004273
DomainBRINP

BRINP3 BRINP2

1.44e-0431302IPR033237
DomainZnf_CHHC

HNRNPH1 HNRNPH2

1.44e-0431302IPR012996
Domainzf-RNPHF

HNRNPH1 HNRNPH2

1.44e-0431302PF08080
DomainsrGAP2

SRGAP2 SRGAP2B

1.44e-0431302IPR030252
DomainPH_DOMAIN

EPS8 ARHGEF19 PLCD4 ALS2 DGKH ARHGAP22 AFAP1 ELMO2 PLCH1

1.48e-042791309PS50003
DomainPH_domain

EPS8 ARHGEF19 PLCD4 ALS2 DGKH ARHGAP22 AFAP1 ELMO2 PLCH1

1.52e-042801309IPR001849
Domain-

IPO5 CIP2A RANBP6 RICTOR CUL7 ELMO2 PRKDC IPO11

1.65e-0422213081.25.10.10
DomainTerpenoid_cyclase/PrenylTrfase

ELMO2 C4A C4B

2.49e-04181303IPR008930
DomainAnaphylatoxin_comp_syst

C4A C4B

4.74e-0451302IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

4.74e-0451302IPR001840
DomainARM-like

IPO5 CIP2A RANBP6 RICTOR CUL7 ELMO2 PRKDC IPO11

6.11e-042701308IPR011989
DomainFF_domain

ARHGAP35 ARHGAP5

7.08e-0461302IPR002713
DomainFF

ARHGAP35 ARHGAP5

7.08e-0461302PS51676
DomainFF

ARHGAP35 ARHGAP5

7.08e-0461302PF01846
DomainFF

ARHGAP35 ARHGAP5

7.08e-0461302SM00441
DomainHEAT

IPO5 RANBP6 PRKDC IPO11

7.11e-04581304IPR000357
DomainPH

ARHGEF19 PLCD4 ALS2 DGKH ARHGAP22 AFAP1 ELMO2 PLCH1

7.40e-042781308SM00233
DomainRhoGAP

SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5

9.15e-04621304SM00324
DomainRhoGAP

SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5

9.72e-04631304PF00620
DomainANATO

C4A C4B

9.87e-0471302SM00104
DomainDesmosomal_cadherin

DSC1 DSG2

9.87e-0471302IPR009122
DomainANAPHYLATOXIN_2

C4A C4B

9.87e-0471302PS01178
DomainANAPHYLATOXIN_1

C4A C4B

9.87e-0471302PS01177
DomainANATO

C4A C4B

9.87e-0471302PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

9.87e-0471302IPR000020
DomainRhoGAP_dom

SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5

1.03e-03641304IPR000198
DomainRHOGAP

SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5

1.03e-03641304PS50238
Domain-

SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5

1.03e-036413041.10.555.10
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

1.31e-0381302IPR019565
DomainThiol-ester_cl

C4A C4B

1.31e-0381302PF10569
DomainMacrogloblnA2_CS

C4A C4B

1.31e-0381302IPR019742
DomainCadherin

FAT4 DSC1 DSG2 KIAA0319 FREM2

1.41e-031181305IPR002126
DomainHEAT_REPEAT

IPO5 RANBP6 PRKDC IPO11

1.44e-03701304PS50077
Domain-

EPS8 ARHGEF19 PLCD4 ALS2 DGKH ARHGAP22 AFAP1 ELMO2 PLCH1

1.68e-0339113092.30.29.30
DomainMAC_perforin

BRINP3 BRINP2

2.09e-03101302IPR001862
DomainA2M

C4A C4B

2.09e-03101302PF00207
DomainA2M_N_2

C4A C4B

2.09e-03101302IPR011625
DomainA2M_comp

C4A C4B

2.09e-03101302IPR011626
DomainA2M_recep

C4A C4B

2.09e-03101302PF07677
DomainA2M_comp

C4A C4B

2.09e-03101302PF07678
DomainNHL_repeat

NHLRC1 LRP1B

2.09e-03101302IPR001258
DomainA2M_N

C4A C4B

2.09e-03101302PF01835
DomainA2M_N

C4A C4B

2.09e-03101302IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

2.09e-03101302IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

2.09e-03101302PS00477
DomainNHL

NHLRC1 LRP1B

2.09e-03101302PF01436
DomainA2M_N_2

C4A C4B

2.09e-03101302PF07703
DomainMacroglobln_a2

C4A C4B

2.09e-03101302IPR001599
DomainMACPF

BRINP3 BRINP2

2.54e-03111302PF01823
DomainARM-type_fold

IPO5 CIP2A RANBP6 RICTOR CUL7 ELMO2 PRKDC IPO11

2.59e-033391308IPR016024
DomainPH_dom-like

EPS8 ARHGEF19 PLCD4 ALS2 DGKH ARHGAP22 AFAP1 ELMO2 PLCH1

2.98e-034261309IPR011993
DomainMACPF

BRINP3 BRINP2

3.03e-03121302IPR020864
DomainMACPF

BRINP3 BRINP2

3.03e-03121302SM00457
DomainRho_GTPase_activation_prot

SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5

3.33e-03881304IPR008936
DomainG_SEPTIN_dom

SEPTIN9 SEPTIN10

3.57e-03131302IPR030379
DomainSeptin

SEPTIN9 SEPTIN10

3.57e-03131302PF00735
DomainG_SEPTIN

SEPTIN9 SEPTIN10

3.57e-03131302PS51719
DomainIMPORTIN_B_NT

IPO5 IPO11

4.14e-03141302PS50166
DomainSeptin

SEPTIN9 SEPTIN10

4.14e-03141302IPR016491
DomainHEAT

IPO5 RANBP6 PRKDC

4.53e-03481303PF02985
DomainEF-hand_like

PLCD4 PLCH1

4.76e-03151302PF09279
DomainPI-PLC-Y

PLCD4 PLCH1

4.76e-03151302PF00387
DomainPLCYc

PLCD4 PLCH1

4.76e-03151302SM00149
DomainPLipase_C_Pinositol-sp_Y

PLCD4 PLCH1

4.76e-03151302IPR001711
DomainPIPLC_Y_DOMAIN

PLCD4 PLCH1

4.76e-03151302PS50008
DomainPI-PLC_fam

PLCD4 PLCH1

4.76e-03151302IPR001192
DomainPLC_EF-hand-like

PLCD4 PLCH1

4.76e-03151302IPR015359
DomainPINT

GPS1 COPS4

5.41e-03161302SM00088
DomainPCI_dom

GPS1 COPS4

6.11e-03171302IPR000717
DomainImportin-beta_N

IPO5 IPO11

6.11e-03171302IPR001494
DomainC345C

C4A C4B

6.11e-03171302SM00643
DomainPCI

GPS1 COPS4

6.11e-03171302PF01399
DomainPI-PLC-X

PLCD4 PLCH1

6.84e-03181302PF00388
DomainPLCXc

PLCD4 PLCH1

6.84e-03181302SM00148
PathwayREACTOME_RHO_GTPASE_CYCLE

ARHGEF19 NCKAP1 DSG2 GPS1 ALS2 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 ELMO2 RHOBTB2 COPS4 PAK3 DOCK6 PHIP

1.08e-0643910715MM15595
PathwayREACTOME_RHO_GTPASE_CYCLE

ARHGEF19 NCKAP1 DSG2 GPS1 ALS2 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 ELMO2 RHOBTB2 COPS4 PAK3 DOCK6 PHIP

1.47e-0645010715M27078
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGEF19 NCKAP1 ALS2 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 PAK3 DOCK6

7.20e-061751079MM15599
PathwayREACTOME_RAC1_GTPASE_CYCLE

ARHGEF19 NCKAP1 ALS2 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 PAK3 DOCK6

1.08e-051841079M41809
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

ARHGEF19 NCKAP1 DSG2 GPS1 ALS2 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 KIF2B ELMO2 RHOBTB2 COPS4 PAK3 DOCK6 PHIP

2.95e-0564910716MM15690
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ABHD6 DGKH ITPR3 RASGRP1

4.81e-05271074M12123
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH2 DNAH17 DNAH8 DNAH11

4.81e-05271074M47755
PathwayREACTOME_CDC42_GTPASE_CYCLE

ARHGEF19 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 DOCK6

7.87e-05941076MM15598
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

ARHGEF19 NCKAP1 DSG2 GPS1 ALS2 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 KIF2B ELMO2 RHOBTB2 COPS4 PAK3 DOCK6 PHIP

1.01e-0472010716M41838
PathwayREACTOME_RHOBTB_GTPASE_CYCLE

GPS1 RHOBTB2 COPS4 PHIP

1.37e-04351074M41738
PathwayREACTOME_RHOBTB_GTPASE_CYCLE

GPS1 RHOBTB2 COPS4 PHIP

1.71e-04371074MM15683
PathwayREACTOME_CDC42_GTPASE_CYCLE

ARHGEF19 SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5 PAK3 DOCK6

1.76e-041551077M41808
PathwayKEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT

DNAH2 DNAH17 DNAH8 DNAH11

3.08e-04431074M47669
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH2 DNAH17 DNAH8 DNAH11

3.68e-04451074M47670
PathwayWP_RETT_SYNDROME

TAF1B CHD4 NCOR1 RHOBTB2

4.72e-04481074M39759
PathwayREACTOME_RAC3_GTPASE_CYCLE

NCKAP1 DSG2 SRGAP2 ARHGAP35 ARHGAP5

7.02e-04931075MM15609
PathwayREACTOME_RAC3_GTPASE_CYCLE

NCKAP1 DSG2 SRGAP2 ARHGAP35 ARHGAP5

7.37e-04941075M41818
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

PLCD4 ITPR3

8.39e-0461072M47960
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ABHD6 DGKH ITPR3

8.66e-04251073MM14511
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

IPO5 CDK17 EPS8 NCKAP1 SEPTIN9 SRGAP2 GRIN1 ARHGAP35 ELFN2 HNRNPH1 SLC12A5 ARHGAP5 TGM1 KARS1 AFAP1 WASHC5 PRICKLE2 CTBP1 C4A C4B UQCRC1 PLCH1 SNRNP200 DNAH11

1.41e-0914311352437142655
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH2 DNAH17 DNAH8 DNAH11

7.53e-097135431178125
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

CDK16 CDK17 EPS8 ACACB NCKAP1 FBF1 RICTOR SRGAP2 CUL7 PRKDC DOCK6 IPO11

1.91e-074461351224255178
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH2 DNAH17 DNAH8 DNAH11

2.11e-071413549373155
Pubmed

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.

PTPRC C4A C4B

2.28e-074135319001138
Pubmed

Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.

SIRPB1 SIRPA PTPRC

2.28e-074135332294445
Pubmed

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.

IPO5 MYOM1 SEPTIN9 FBF1 SRGAP2 HNRNPH1 TGM1 KARS1 C4A C4B

2.33e-072921351012819125
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

EPS8 DSG2 SEPTIN9 SRPK1 SRGAP2 MSH3 HNRNPH1 HNRNPH2 ITPR3 AFAP1 CTBP1 PRKDC SEPTIN10 SNRNP200

3.17e-076601351432780723
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

CDK16 EPS8 ACACB DSG2 RICTOR SRGAP2 FAM171B ARHGAP5 ELMO2 CTBP1 PLCH1

8.39e-074211351136976175
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

EPS8 ACACB NCKAP1 DSG2 SEPTIN9 CIP2A HAUS3 LRP1B HNRNPH1 HNRNPH2 ARHGAP5 NCOR1 WASHC5 ELMO2 N4BP2

1.24e-068531351528718761
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

MED16 ATAD5 MED14 RANBP6 SRPK1 CHD4 MSH3 HNRNPH2 PLCH1 SNRNP200 PHIP IPO11

1.25e-065331351230554943
Pubmed

A protein interaction landscape of breast cancer.

RAD51B IPO5 CDK16 DSC1 DSG2 CIP2A GPS1 SRPK1 MSH3 CUL7 ITPR3 COPS4 SEPTIN10

1.25e-066341351334591612
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

UBR1 DSC1 NCKAP1 SEPTIN9 TAF1B SRPK1 RICTOR CHD4 CHD1L MSH3 HNRNPH1 HNRNPH2 TGM1 KARS1 WASHC5 PRKDC UQCRC1 SNRNP200 PHIP

1.28e-0613531351929467282
Pubmed

Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.

ABCA13 SIRPB1 SIRPA KARS1 VSX2

1.36e-0649135531609468
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

DSG2 SEPTIN9 SRGAP2 CHD1L MSH3 HNRNPH1 ITPR3 KARS1 PRKDC SEPTIN10

1.56e-063601351033111431
Pubmed

Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment.

SIRPB1 SIRPA PRKDC

1.98e-067135323293079
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH2 DNAH8 DNAH11

1.98e-06713539256245
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

IPO5 NCKAP1 SEPTIN9 GPS1 MED14 MSH3 NCOR1 PIGT ELMO2 UQCRC1 SNRNP200 IPO11

2.08e-065601351235241646
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

DSC1 DSG2 SEPTIN9 CHD4 HNRNPH1 HNRNPH2 KARS1 C4A C4B PRKDC SNRNP200

2.80e-064771351131300519
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

IPO5 DSG2 SEPTIN9 SRPK1 CHD4 KARS1 COPS4 PRKDC DOCK6 IPO11

3.89e-063991351037536630
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

NCKAP1 SEPTIN9 GPS1 MED14 CHD4 MSH3 HNRNPH1 HNRNPH2 KARS1 PRKDC UQCRC1 DNAH8 SNRNP200

3.91e-067041351329955894
Pubmed

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.

ACACB TAF1B GPS1 CUL7 LRP1B HNRNPH1 COPS4 PRKDC

5.39e-06244135830349055
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

IPO5 EPS8 NCKAP1 GRIN1 SIRPB1 SIRPA HNRNPH1 SLC12A5 PIGT CTBP1 UQCRC1 ATP1A4

5.95e-066211351222794259
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FAT4 SEPTIN9 DNAH2 DGKH GRIN1 HNRNPH1 ARHGAP5 FREM2 KARS1 PRICKLE2 PRKDC NCR2 SNRNP200

6.31e-067361351329676528
Pubmed

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

FAT4 NCKAP1 DSG2 FREM2 PRKDC

6.51e-0667135521875946
Pubmed

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.

SIRPB1 SIRPA PRKDC

6.73e-0610135317982459
Pubmed

Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts.

SIRPB1 SIRPA PRKDC

6.73e-0610135328783664
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

CDK17 NCKAP1 SRPK1 ALS2 SRGAP2 HNRNPH1 PRKDC SNRNP200

7.43e-06255135815324660
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

CDK17 DSC1 SEPTIN9 FBF1 HAUS3 DGKH SRGAP2 CUL7 HNRNPH1 N4BP2 PRKDC SNRNP200

7.92e-066391351223443559
Pubmed

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.

IPO5 SEPTIN9 STT3A PRKDC SNRNP200

9.29e-0672135536376293
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ACACB NCKAP1 STXBP5L SEPTIN9 ABHD6 RICTOR GRIN1 ARHGAP35 FAM171B LRP1B ELFN2 HNRNPH2 WASHC5 PRICKLE2 PAK3 SEPTIN10

9.45e-0611391351636417873
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

DSC1 ACACB CHD4 MSH3 HNRNPH1 TGM1 NCOR1 PRKDC SNRNP200

1.15e-05357135937059091
Pubmed

A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.

GPS1 CHD4 COPS4 PHIP

1.16e-0536135429089422
Pubmed

Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.

UBR1 SIRPB1 SIRPA

1.23e-0512135316670015
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

CHD4 NCOR1 CTBP1 C4A PRKDC SNRNP200

1.28e-05131135634551306
Pubmed

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

DET1 GPS1 COPS4 PHIP

1.30e-0537135416949367
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

IPO5 SRPK1 RICTOR ITPR3 PRKDC DOCK6 SNRNP200

1.48e-05202135733005030
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.50e-052135222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.50e-052135216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.50e-052135215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.50e-052135219062096
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.50e-052135219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.50e-05213522459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.50e-052135217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.50e-052135212207352
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.50e-052135227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.50e-052135222387014
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.50e-052135223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.50e-052135223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.50e-05213523037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.50e-052135211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.50e-05213524216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.50e-05213526950384
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.50e-05213528660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.50e-05213528428773
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.50e-052135224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.50e-052135221345967
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.50e-05213522572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.50e-05213522302180
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.50e-052135222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.50e-052135218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.50e-052135229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.50e-05213526589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.50e-052135225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.50e-052135217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.50e-05213526149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.50e-05213526149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.50e-052135212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.50e-05213523542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.50e-05213522387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.50e-052135216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.50e-05213527365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.50e-05213527391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.50e-052135217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.50e-052135229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.50e-052135217971229
Pubmed

The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.

ARHGAP35 ARHGAP5

1.50e-052135236178483
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.50e-05213526881182
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

1.50e-052135217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

1.50e-052135221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

1.50e-05213526978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

1.50e-052135235898513
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

1.50e-052135228873507
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

1.50e-0521352276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

1.50e-05213526832377
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

1.50e-05213523794341
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

1.50e-052135222785613
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

1.50e-052135232691186
Pubmed

The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.

C4A C4B

1.50e-05213528390682
Pubmed

Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).

C4A C4B

1.50e-05213523902619
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

1.50e-05213527373044
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

1.50e-05213523696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

1.50e-05213521357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

1.50e-052135216098595
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

1.50e-052135215787745
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

1.50e-052135230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

1.50e-05213526559257
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

1.50e-052135234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

1.50e-052135220506482
Pubmed

RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.

ARHGAP35 ARHGAP5

1.50e-052135223552690
GeneFamilyDyneins, axonemal

DNAH2 DNAH17 DNAH8 DNAH11

2.23e-06171034536
GeneFamilyRho GTPase activating proteins|BCH domain containing

SRGAP2 ARHGAP35 ARHGAP22 ARHGAP5

1.87e-04501034721
GeneFamilyCD molecules|V-set domain containing|C1-set domain containing|Signal regulatory proteins

SIRPB1 SIRPA

3.18e-0451032747
GeneFamilyDesmosomal cadherins

DSC1 DSG2

6.63e-04710321188
GeneFamilyCOP9 signalosome

GPS1 COPS4

1.13e-0391032932
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

1.13e-03910321234
GeneFamilySeptins

SEPTIN9 SEPTIN10

2.41e-03131032732
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

CASP2 ELFN2 ITPR3 TMEM132C NCOR1

3.78e-031811035694
GeneFamilyArmadillo repeat containing|Importins

IPO5 IPO11

4.63e-03181032596
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCD4 PLCH1

5.16e-03191032832
CoexpressionGSE2770_IL12_ACT_VS_ACT_CD4_TCELL_6H_DN

LYPD6 FBF1 HAUS3 HNRNPH1 ARSF N4BP2 PRICKLE2 PAK3

6.08e-061921328M6064
CoexpressionGSE3982_MAST_CELL_VS_MAC_UP

ADAMTS3 ABHD6 SRPK1 DNAH17 CTBP1 PRKDC MUC2 PHIP

7.90e-061991328M5429
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ABCA13 STXBP5L LRP1B FREM2 PLCH1 ATP1A4 DNAH11

9.56e-0818413582cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ABCA13 STXBP5L LRP1B FREM2 PLCH1 ATP1A4 DNAH11

9.56e-081841358ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ABCA13 STXBP5L LRP1B FREM2 PLCH1 ATP1A4 DNAH11

9.56e-0818413582b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6 KATNAL2 ACACB ARHGEF38 LRP1B TMEM132C PRICKLE2

1.69e-0618713577ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellfacs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HNRNPH1 HNRNPH2 STT3A SLC38A2 ARHGAP5 FREM2 AFAP1

2.47e-06198135722559b161e67b49fe8028bfaf861e069063599f5
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOM1 ABCA13 LRP1B C4B PLCH1 DNAH11

1.29e-05169135612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCelldroplet-Liver-LIVER_NPC-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP1 CUL7 ADGRL4 SLC12A5 TSPAN7 DNAH8

1.79e-051791356025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCellIPF-Epithelial-Mesothelial|IPF / Disease state, Lineage and Cell class

ADAMTS3 DSG2 TGM1 AFAP1 C4A C4B

1.85e-0518013561fa54bf4dba72866b2295639d991af639341bc08
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS3 SPEF2 RASGRP1 FREM2 GSG1L SEPTIN10

1.91e-05181135613270b6ba6a9c8e5681c6f40000c643ce1d9344a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS3 SPEF2 RASGRP1 FREM2 GSG1L SEPTIN10

1.91e-0518113563e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRINP3 ADAMTS3 ARHGEF38 FAM81A RASGRP1 FREM2

1.91e-051811356aa233b652921848af2257cc3687a7a09c3acfb67
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 ARHGEF38 DGKH LRP1B ITPR3 PRICKLE2

1.91e-05181135622363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 ARHGEF38 NAALADL2 LRP1B ITPR3 SEPTIN10

1.97e-051821356a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPS8 LYPD6 FAT4 AFAP1 ARSF N4BP2

1.97e-051821356420a8fd30543e37a66ba0786215d056d308660d0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRINP3 SEPTIN9 ARHGEF38 FAM171B NAALADL2 LRP1B

2.09e-0518413568fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KATNAL2 ACACB ARHGEF38 NAALADL2 LRP1B PRICKLE2

2.09e-051841356e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SPEF2 CASP2 SRGAP2 ITPR3 WASHC5 SRGAP2B

2.16e-0518513561b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SPEF2 CASP2 SRGAP2 ITPR3 WASHC5 SRGAP2B

2.16e-05185135602cbf492bc40abebaa93a3a208888afae72fbe06
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 ARHGEF38 DGKH NAALADL2 LRP1B ITPR3

2.29e-05187135687b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 ARHGEF38 DGKH NAALADL2 LRP1B ITPR3

2.29e-05187135642a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 ARHGEF38 DGKH NAALADL2 LRP1B ITPR3

2.29e-05187135664afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6 ARHGEF38 NAALADL2 LRP1B TMEM132C PRICKLE2

2.36e-0518813563cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCellCOPD-Epithelial-Mesothelial|COPD / Disease state, Lineage and Cell class

NCKAP1 ADAMTS3 TGM1 AFAP1 C4A C4B

2.43e-05189135679bb2593ad5d17f94b17972884241f03a0f43770
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

EPS8 ARHGEF38 ITPR3 FREM2 RHOBTB2 PLCH1

2.43e-051891356dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRINP3 ARHGEF38 DGKH NAALADL2 LRP1B ITPR3

2.43e-051891356e059be2965cca70ff5576df055d0af1775b76e00
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RAD51B ADAMTS3 ARHGEF38 NAALADL2 LRP1B RASGRP1

2.43e-05189135690aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAD51B ADAMTS3 ARHGEF38 NAALADL2 LRP1B RASGRP1

2.51e-0519013564836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEPTIN9 NAALADL2 LRP1B FAM81A RASGRP1 KLHL8

2.58e-0519113563e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

EPS8 ARHGEF38 NAALADL2 FREM2 RHOBTB2 PLCH1

2.58e-051911356276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

EPS8 ARHGEF38 ITPR3 FREM2 RHOBTB2 PLCH1

2.66e-05192135658c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

EPS8 ARHGEF38 ITPR3 FREM2 RHOBTB2 PLCH1

2.66e-051921356cc9911e182a289779a2612bc213daae5607689e7
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 SPEF2 MGAT4A DGKH ADGRL4 DOCK6

2.74e-051931356e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

EPS8 ARHGEF38 ITPR3 FREM2 RHOBTB2 PLCH1

2.74e-051931356738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 SPEF2 DGKH ADGRL4 PRICKLE2 DOCK6

2.82e-05194135668004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 SPEF2 MGAT4A DGKH ADGRL4 DOCK6

2.82e-0519413560b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

NCKAP1 ABCA13 HNRNPH1 PRICKLE2 PLCH1 DNAH11

2.98e-051961356af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

NCKAP1 ABCA13 HNRNPH1 PRICKLE2 PLCH1 DNAH11

2.98e-0519613566d02d494196e3f857d53eea46d9419690d43beca
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAT4A RICTOR RASGRP1 PTPRC N4BP2 PRKDC

2.98e-0519613564a880a5d2c7047c050c7d6dd62186f35dc5c01f7
ToppCellCOVID-19_Severe-Neu_4|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

ABCA13 CIP2A CHD1L HNRNPH1 ARHGAP5 N4BP2

3.16e-051981356bfdddddef9f3f0eb6af013873dec4e06b7c78c58
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP1 HNRNPH1 HNRNPH2 STT3A SLC38A2 ARHGAP5

3.25e-0519913568d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCellCOVID-19_Severe-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

ABCA13 CIP2A CHD1L HNRNPH1 ARHGAP5 N4BP2

3.25e-0519913560e327479bbda5a16643cf317d293a2918d619f87
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FAM171B LRP1B KIAA0319 ARSF TSPAN7 PLCH1

3.34e-05200135607d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell10x5'v1-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

EPS8 DSG2 ABHD6 P4HA3 ADGRL4 TSPAN7

3.34e-052001356ae429f2de652cc1976e63644781197e9ce0e70c8
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)|Neuronal / cells hierarchy compared to all cells using T-Statistic

EPS8 LYPD6 FAT4 AFAP1 ARSF N4BP2

3.34e-05200135675649534a98bc738fca62d071de0978dc61eb24f
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

STXBP5L LRP1B TEX47 GSG1L DNAH8

9.43e-0515013550205318a870e091add66ee4305747dda9f51510d
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRINP3 ACACB SEPTIN9 ARHGEF38 FREM2

9.73e-051511355f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

CDK17 RICTOR DGKH HNRNPH1 PTPRC

1.13e-0415613551545169694f686d28648a68b552c2ae606599d66
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue|TCGA-Bladder / Sample_Type by Project: Shred V9

TCF21 ACACB MYOM1 PLCD4 TMEM132C

1.28e-0416013558a41e2c96e0e170ac35daf6c403bf961b8d7c30b
ToppCellTCGA-Bladder-Solid_Tissue_Normal|TCGA-Bladder / Sample_Type by Project: Shred V9

TCF21 ACACB MYOM1 PLCD4 TMEM132C

1.28e-041601355d6678996e12eaf2b735f1dfae32418cb2fabf268
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue|TCGA-Bladder / Sample_Type by Project: Shred V9

TCF21 ACACB MYOM1 PLCD4 TMEM132C

1.28e-041601355c8dc575562b463fd30832d322c28006f18f7ab9c
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA13 CIP2A LRP1B FREM2 TRIM60

1.35e-041621355bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CYSLTR1 DNAH2 SIRPA PTPRC IPO11

1.35e-041621355ec29c6f1c31e41ddcb041a49c593910edaf0532c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RAD51B ADAMTS3 SEPTIN9 FAM81A RASGRP1

1.35e-041621355285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

BRINP3 LRP1B CTCFL GSG1L DNAH11

1.39e-0416313551e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF38 ELFN2 FREM2 RHOBTB2 C4A

1.43e-04164135585f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF38 ELFN2 FREM2 RHOBTB2 C4A

1.43e-041641355144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCellfacs-Kidney-nan-3m-Lymphocytic|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC1 ITPR3 AURKC RASGRP1 PTPRC

1.47e-041651355ba041deb0d9c187f251493ccd4794b5f09abd5aa
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Lymphoid_DC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLCD4 GRIN1 ARHGAP22 ATP1A4 DNAH11

1.56e-0416713558b223333c0c7a85b5a1af6f2f5b12ee0d94357f6
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 SPEF2 DNAH2 DGKH DNAH11

1.65e-04169135514aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellNS-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KATNAL2 FBXW9 DSG2 IGFBPL1 CCDC171

1.69e-041701355f6a0162bb690dbc19ff1cec64cb933744ad3b496
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRINP3 C12orf56 STXBP5L SLC12A5 KIAA0319

1.69e-0417013556a98f47f8c2b5b15e09169bd82eff1e6bf76e5a6
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LYPD6 DGKH LRP1B PAK3 WDR17

1.69e-0417013555570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DGKH ADGRL4 OR10W1 TSPAN7 DOCK6

1.74e-041711355b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CDK17 FAT4 ADGRL4 BRINP2 DOCK6

1.74e-0417113551597459c971d6befa991d59dc66b41b6a522f797
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIRPA HPS3 RASGRP1 PTPRC CCDC171

1.79e-0417213551f335ccb92b22d0412954e8fc3af212f96410b67
ToppCelldroplet-Liver-nan-3m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIRPA HPS3 RASGRP1 PTPRC CCDC171

1.79e-041721355bb96c896d125e10b71e94e2bdad243899045af5c
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

DSG2 TGM1 BRINP2 C4B GSG1L

1.84e-041731355e05cddf5bf63cf419343ff229453327519765be8
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

DSG2 TGM1 BRINP2 C4B GSG1L

1.84e-04173135574ad5ed33821b8816c9c8e67c50ee4496ba18e2f
ToppCellTCGA-Prostate-Solid_Tissue_Normal-Prostate_normal_tissue-Prostate_normal_tissue|TCGA-Prostate / Sample_Type by Project: Shred V9

ABHD6 TMEM132C ARSF PRICKLE2 PAK3

1.89e-041741355de6c1ebca36ec8060ddcafc270c45d6ab1caec2c
ToppCellTCGA-Prostate-Solid_Tissue_Normal|TCGA-Prostate / Sample_Type by Project: Shred V9

ABHD6 TMEM132C ARSF PRICKLE2 PAK3

1.89e-041741355abdb5a89118b82bb64469fc41c163bd2b282b0c0
ToppCellTCGA-Prostate-Solid_Tissue_Normal-Prostate_normal_tissue|TCGA-Prostate / Sample_Type by Project: Shred V9

ABHD6 TMEM132C ARSF PRICKLE2 PAK3

1.89e-0417413550dde0e9ef987c52cb29a238f15568a83424d02f6
ToppCelldroplet-Lung-21m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATAD5 MED14 ARHGAP35 FAM81A KLHL8

1.94e-0417513556751ee4b312d7f87275f2c35e5878cfc3be3ebe3
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ABHD6 MED14 GRIN1 KIAA0319 WASHC5

1.99e-041761355a9e77681bcd36c382d53eb6f771349d55f98d744
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAH2 ADGRL4 SLC12A5 TSPAN7 IPO11

2.10e-041781355aa44851653d276226b922ee14dd1fc8d1a844cdf
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

MYOM1 ARHGAP35 SLC12A5 ITPR3 CTBP1

2.15e-04179135568511e87b12b8253de7771e5ccfc5869248b8450
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

EPS8 ARHGEF38 FREM2 RHOBTB2 PLCH1

2.21e-041801355198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

CDK17 DGKH HNRNPH1 PTPRC SRGAP2B

2.27e-041811355f2315414e714ac86211546a935660c4be6e85f1b
ToppCellIPF-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

DSG2 TGM1 AFAP1 C4A C4B

2.38e-0418313557df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

EPS8 ARHGEF38 FREM2 RHOBTB2 PLCH1

2.44e-041841355369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRINP3 ARHGEF38 DGKH NAALADL2 LRP1B

2.44e-041841355d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPS8 LYPD6 FAT4 AFAP1 N4BP2

2.44e-04184135532473dbdb2de66391157c5814ef34e790806e4f2
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

ADAMTS3 TGM1 AFAP1 C4A C4B

2.51e-04185135523579988036fc1925992c31919750f9b3fe9f790
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPS8 FAT4 AFAP1 ARSF N4BP2

2.51e-041851355cefd81adb480c027545a5c78dcd05669783717f4
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CYSLTR1 ARHGAP22 TGM1 TSPAN7 GSG1L

2.51e-041851355492529121cb9e88bd3c0db6b54af3cd2979572bc
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK17 MED14 RFFL RASGRP1 PTPRC

2.51e-041851355a2cae8c657e4f4d121476798e424876f7e247973
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP1 CUL7 ADGRL4 TSPAN7 DOCK6

2.51e-041851355bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

ABCA13 SPEF2 DNAH2 KIAA0319 DNAH11

2.51e-04185135518a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDK17 MED14 RFFL RASGRP1 PTPRC

2.51e-041851355d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS3 ABCA13 RASGRP1 FREM2 DNAH11

2.57e-0418613555c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FAT4 BRINP3 TCF21 TMEM132C PAK3

2.57e-0418613557def03dd856b765bd3f493288641981c4f7fd26e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EPS8 ABCA13 ARHGEF38 SRPK1 PLCH1

2.57e-041861355acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCelldroplet-Tongue-nan-24m-Epithelial-parabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC1 TGM1 TSPAN7 PRICKLE2 PAK3

2.57e-04186135518c06041c6c8a0ebac17b3c8aaebd67e652d315a
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CYSLTR1 ARHGAP22 TGM1 TSPAN7 GSG1L

2.63e-0418713558e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCellHealthy-HSPC|World / disease group, cell group and cell class

FBXW9 DSG2 SLC12A5 ARHGAP22 CCDC171

2.63e-0418713558cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RAD51B ADAMTS3 NAALADL2 FAM81A RASGRP1

2.63e-041871355f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

CDK17 RICTOR DGKH HNRNPH1 PTPRC

2.70e-041881355ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LYPD6 FAT4 AFAP1 ARSF N4BP2

2.70e-041881355c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

ABCA13 SPEF2 DNAH2 KIAA0319 DNAH11

2.70e-04188135561a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LYPD6 BRINP3 ARHGEF38 NAALADL2 LRP1B

2.70e-0418813552ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CYSLTR1 ARHGAP22 TGM1 TSPAN7 GSG1L

2.70e-0418813559655a4c47b644a870017d349b99063e17dbae572
DrugBumetanide [28395-03-1]; Down 200; 11uM; PC3; HT_HG-U133A

ACACB MED16 SEPTIN9 CASP2 SRGAP2 SIRPA CUL7 RHOBTB2 PAK3 CTBP1

2.63e-07195135105117_DN
Diseaselevel of tyrosine-protein phosphatase non-receptor type substrate 1 in blood serum

SIRPB1 SIRPA

1.99e-0521322OBA_2040362
Diseasesystemic lupus erythematosus (implicated_via_orthology)

RASGRP1 PTPRC C4A C4B

4.12e-05431324DOID:9074 (implicated_via_orthology)
DiseaseHennekam syndrome (is_implicated_in)

FAT4 ADAMTS3

5.94e-0531322DOID:0060366 (is_implicated_in)
DiseaseHennekam lymphangiectasia-lymphedema syndrome

FAT4 ADAMTS3

5.94e-0531322C0340834
Diseasesignal-regulatory protein beta-1 measurement

SIRPB1 SIRPA

7.00e-0491322EFO_0802069
DiseaseInhalant adrenergic use measurement

SPEF2 RANBP6 PTPRC MUC2

9.25e-04961324EFO_0009941
Diseasesevere acute respiratory syndrome, COVID-19

SEPTIN9 SPEF2 SRGAP2 LRP1B TMEM132C TSPAN7 PRICKLE2 GSG1L

9.35e-044471328EFO_0000694, MONDO_0100096
Diseasegallbladder cancer (is_implicated_in)

RICTOR LRP1B

1.50e-03131322DOID:3121 (is_implicated_in)
Diseaseurate measurement, bone density

KATNAL2 TAF1B NAALADL2 ARHGAP22 RHOBTB2 PRKDC SEPTIN10 DNAH8 DNAH11

1.92e-036191329EFO_0003923, EFO_0004531
Diseaseemployment status

ARHGAP22 IPO11

2.01e-03151322EFO_0005241
Diseasevascular endothelial growth factor measurement

BRINP3 DNAH2 DGKH

2.04e-03561323EFO_0004762
DiseaseAdenocarcinoma of lung (disorder)

IPO5 MSH3 ARHGAP35 AURKC PRKDC

2.39e-032061325C0152013
Diseaselobe attachment

NHLRC1 FAT4 PLCD4 PRKDC NCR2

2.44e-032071325EFO_0007667
Diseaseamino acid measurement

IPO5 FAT4 ACACB OR8B3 KIF2B BRINP2 PRKDC OR8B2 MUC2

3.52e-036781329EFO_0005134
DiseaseSevere Combined Immunodeficiency

PTPRC PRKDC

3.58e-03201322C0085110
Diseasesusceptibility to mononucleosis measurement

FAT4 DNAH2 DNAH8

3.70e-03691323EFO_0008403
Diseasebilirubin measurement

UBR1 FAT4 ARHGEF38 KLHL8 CCDC171 PHIP DNAH11

3.83e-034421327EFO_0004570
DiseaseNystagmus

MSH3 NAALADL2

3.94e-03211322HP_0000639
DiseaseLupus Erythematosus, Systemic

RASGRP1 C4A C4B

4.01e-03711323C0024141
DiseaseIntellectual Disability

CDK16 CASP2 GRIN1 STT3A KARS1 RHOBTB2 PHIP

4.07e-034471327C3714756
Diseaseneurodegenerative disease (implicated_via_orthology)

UBR1 FAT4 GRIN1 TSPAN7

4.16e-031451324DOID:1289 (implicated_via_orthology)
Diseaseproprotein convertase subtilisin/kexin type 9 measurement

ABHD6 ADGRL4

4.33e-03221322EFO_0009312

Protein segments in the cluster

PeptideGeneStartEntry
LFLEIVSEKSRYSLH

ABHD6

246

Q9BV23
TLYELEKITFTLSHR

ADGRL4

346

Q9HBW9
VLVKSESSLSIFYDR

C2orf16

1026

Q68DN1
SIITVSYEEFLKSHK

ATAD5

261

Q96QE3
AISFLERHSKETFLL

ARSF

271

P54793
FFETVHIYLRSRIKS

BRINP3

621

Q76B58
SASHSETYRRILKVD

AURKC

241

Q9UQB9
AEISKYLTLSSIKDH

ARL5B

136

Q96KC2
YHTITLTREDLEKFK

CTBP1

76

Q13363
EKYILTLQTVHFTSE

CTCFL

76

Q8NI51
ISHATEELETYRKRA

CTAGE1

391

Q96RT6
LEKLTSLSDRYVSHF

C4B

1501

P0C0L5
HELATTERRFYSKLS

ALS2

696

Q96Q42
FLELLDHEYLTSTVR

AFAP1

11

Q8N556
DIHRSKLLSTYSAEE

ARHGEF38

571

Q9NXL2
HSSRSITYVEKDSLV

CCDC171

926

Q6TFL3
EHLTYLEFKSFRRIS

RASGRP1

211

O95267
TTLNSYTKTVIEFRH

GSG1L

236

Q6UXU4
LDREKVSHYVLTIKS

FAT4

2731

Q6V0I7
VYSESTSLAEKLLFH

ANKRD20A5P

141

A0PJZ0
KVLDFRNTLETHTYL

DNAH11

1026

Q96DT5
TVLVHTTETARLRYF

DNAH11

2481

Q96DT5
LHTFKITALLETLDF

ABCA13

3211

Q86UQ4
HLFIKYTSEDVVTLR

DET1

341

Q7L5Y6
TEEKLLLTSSKVHLY

RAD51B

166

O15315
LKEASEFHSRYITTV

PPP2R3B

251

Q9Y5P8
ASIARLSAEHKTTYE

FAM81A

141

Q8TBF8
FLTEETKHRLFTTTE

ITPR3

2146

Q14573
IITILESYVKHFAIS

MSL3P1

131

P0C860
TRFYDKVLSLHEDST

P4HA3

66

Q7Z4N8
RSTIRENITYLKHDS

ACACB

2396

O00763
KFELITSEASYIHSL

ARHGEF19

381

Q8IW93
IHFKSSVISIYVSES

DSG2

386

Q14126
REVKSYLIETLHSLI

MGAT4A

146

Q9UM21
YFIRDVKSLTLFVTH

MSH3

996

P20585
EHTKSIYTRSVVESI

PAK3

211

O75914
ALYTTSTDKTIRVHV

FBXW9

401

Q5XUX1
ADTRVHKTALYIISF

OR10V1

191

Q8NGI7
TTSYTFIVAALLKIH

OR10W1

206

Q8NGF6
YSGRTILKSIHLSDE

LRP1B

2191

Q9NZR2
EILYHTVARTKISDD

NCR2

256

O95944
RALLTFYHVTKTLAS

IPO11

146

Q9UI26
LKSELRLTFVYDTAI

FREM2

2696

Q5SZK8
IEIFKSSRAEVRTHY

HNRNPH2

181

P55795
LVKFVYSSRLTLTVD

KLHL8

121

Q9P2G9
LTIKDDTIYLTRHLA

MUC2

96

Q02817
KSRALELHTELEYSV

KATNAL2

441

Q8IYT4
FSLVKRYLHVTSLLD

CUL7

251

Q14999
YEEIHRKLSEATRSS

GPS1

91

Q13098
LSYKTIVHESERLEA

COPS4

211

Q9BT78
SLTEIRSEILHYATF

DNAH8

1031

Q96JB1
STVTVLDLSKYRSFH

IGFBPL1

256

Q8WX77
IVHTDKSLTLVFEYL

CDK17

256

Q00537
TIYLEAHSRTLSEEK

KIF9

221

Q9HAQ2
IEIFKSSRAEVRTHY

HNRNPH1

181

P31943
ISYVFIVTSILHIKS

OR8B3

216

Q8NGG8
TIYEDSVATHLTKIL

DGKH

486

Q86XP1
VYILTKVSDILHSIF

IPO5

836

O00410
LSRADLTEYLSTHYK

UQCRC1

211

P31930
HLLKLTVSSLDYSRD

RICTOR

696

Q6R327
EYLTSHLEIRFTKSI

NCKAP1

706

Q9Y2A7
LSTLIEFLLHRAYSE

MED14

51

O60244
DYHTKLFLIAISSTL

MED16

546

Q9Y2X0
RKDSIRTIYTSLHNE

KICS2

86

Q96MD2
LRYVTSDELLHKYSS

PRICKLE2

801

Q7Z3G6
TRSSLTYKYIIHEDS

ADAMTS3

816

O15072
ESAHRSRIKVLETSY

FBF1

626

Q8TES7
SEEHLRRSLKTILTY

DOCK6

1521

Q96HP0
ITKLAEISHRLEEFY

DOCK6

1776

Q96HP0
ASLVHTTETIRIRYF

DNAH17

2426

Q9UFH2
RLVESGTKLLSHYSE

ELMO2

131

Q96JJ3
HTEKSLTLVFEYLDK

CDK16

231

Q00536
KQESRFHVLLTTYEI

CHD1L

141

Q86WJ1
VSKEFLARHRVTSYT

CXCR1

326

P25024
IDTKDYSTHRLYQVL

HAUS3

441

Q68CZ6
RDFTVKDIIYLHPST

LYPD6

26

Q86Y78
SIYTTHDLILSSERK

DSC1

76

Q08554
HDLILSSERKSFSIF

DSC1

81

Q08554
EIKRLSTEHSSVSEY

EPS8

471

Q12929
ASVKFHVLLTSYELI

CHD4

841

Q14839
DAYISLFILSIDKSH

DNAH2

3636

Q9P225
YHSVTSLEKILTVLT

RNASE11

171

Q8TAA1
YKKLRLSTDTVEHSL

CASP2

151

P42575
KDITAYHTVFLTAIL

FAM171B

346

Q6P995
SLLVLDTASHSIKVY

NHLRC1

376

Q6VVB1
LEKLTSLSDRYVSHF

C4A

1501

P0C0L4
IEEYRRHLDSSKISV

KIF2B

191

Q8N4N8
ISYVFIVTSILHIKS

OR8B2

216

Q96RD0
KDLTTFLYHLRITAE

SLC12A5

896

Q9H2X9
STEKLTDVARYHIET

SPEF2

1406

Q9C093
ILHILESSSDTLYKV

TEX47

96

Q8TBZ9
ITDFLTQTHKLSLYL

TEX47

171

Q8TBZ9
LVIYLKSVSFRSFTH

PLCD4

496

Q9BRC7
VSYHILRAETSFFLK

TMEM132C

51

Q8N3T6
VDISLTDFIQKYSHL

KARS1

101

Q15046
ISSYVLSDDIKLHSL

HPS3

301

Q969F9
VKDLRDYLSLHDIST

RFFL

106

Q8WZ73
FSFLLRIKTSLLHEE

TAF1B

546

Q53T94
RTAHEISLKRSYESV

NCOR1

1236

O75376
VRIFAHKIYLSTSSS

RHOBTB2

276

Q9BYZ6
ITSSIHFEAYRVKRL

SEPTIN9

551

Q9UHD8
FTTIVTYHLTKELKD

STT3A

126

P46977
SYSIHSTAKVVLTRE

SIRPA

206

P78324
VKRESRDHTTLSDIY

SRGAP2B

106

P0DMP2
SYIRTEKLLLHTCTE

WDR17

1141

Q8IZU2
HIATEITAKFTALYS

ARHGAP5

906

Q13017
HYTETALDEIRLLKS

SRPK1

116

Q96SB4
KRIELSVLSYHSSFS

ARHGAP35

831

Q9NRY4
SDILHSLFSTYKEKI

RANBP6

851

O60518
YKFSRHEITTEIVSL

STXBP5L

541

Q9Y2K9
TTDVHTVASLLKLYL

ARHGAP22

221

Q7Z5H3
YSIHSTAKVVLTRED

SIRPB1

206

Q5TFQ8
KTFFETVHVYLRSRI

BRINP2

636

Q9C0B6
DHKLTLEELSTKYSV

ATP1A4

51

Q13733
VYKILSTHLLESDSL

CLOCK

166

O15516
VKSFYRTLITLLAHS

CIP2A

186

Q8TCG1
LYVISTTSSIFLHLK

C12orf56

276

Q8IXR9
LSTFRKHSLSSVTYV

CYSLTR1

306

Q9Y271
YEVAKLTHAISIFTE

WASHC5

671

Q12768
EHISSVLSDYKSALR

PHIP

1416

Q8WWQ0
LISKYSLRELHLSFT

PIGT

76

Q969N2
LSVLLKADRLFHTSY

PIGT

201

Q969N2
VSIFSLYSVHLLLKT

SLC38A2

111

Q96QD8
LKLSEYTHSSLFLAL

SPDYC

101

Q5MJ68
VKRESRDHTTLSDIY

SRGAP2

106

O75044
HSLETKSYRVSEDLV

UBR1

591

Q8IWV7
SKLDTLRLASSYIAH

TCF21

116

O43680
EELKIKRSLFTYHDS

SEPTIN10

156

Q9P0V9
VELSDYVSTLKHLLR

TRIM60

221

Q495X7
YTLTSKILFRDVVET

PLCH1

361

Q4KWH8
VFTTYISLLADTKLD

PRKDC

1671

P78527
TKETRETYEVLLSFI

SNRNP200

106

O75643
SRRTVKLHLYLSVTF

TGM1

606

P22735
VFRHEIKDTFLRTYT

TSPAN7

111

P41732
SSTYTLRVFELRHSK

PTPRC

1096

P08575
VTLDKLRAHTEYTFC

ELFN2

346

Q5R3F8
HRTIFTSYQLEELEK

VSX2

151

P58304
KIRAHSDLSTVIVFY

KIAA0319

856

Q5VV43
NILYHLDEKTSRFSI

NAALADL2

731

Q58DX5
VIKYLISHSFRFSEI

N4BP2

1746

Q86UW6
RLSLRKTLEETETYH

MYOM1

251

P52179
SIYSDKSIHLSFLRT

GRIN1

126

Q05586