Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transferrin receptor activity	TFR2 TFRC	4.11e-06	2	41	2	GO:0004998
GeneOntologyMolecularFunction	poly-purine tract binding	DAZAP1 LARP4 PABPC4	5.95e-05	37	41	3	GO:0070717
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	NCOA2 LHX1 TFCP2L1 HIF3A PER2 RUNX3 HOXD11 EGR3 NEUROD4 ZBTB4	1.92e-04	1271	41	10	GO:0000987
GeneOntologyMolecularFunction	transcription corepressor binding	BSN PER2 RUNX3	2.41e-04	59	41	3	GO:0001222
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NCOA2 LHX1 TFCP2L1 HIF3A PER2 RUNX3 HOXD11 EGR3 NEUROD4 ZBTB4	5.80e-04	1459	41	10	GO:0000977
GeneOntologyMolecularFunction	cargo receptor activity	CUBN TFR2 TFRC	7.06e-04	85	41	3	GO:0038024
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NCOA2 TFCP2L1 HIF3A PER2 RUNX3 HOXD11 EGR3 NEUROD4 ZBTB4	7.84e-04	1244	41	9	GO:0000978
GeneOntologyMolecularFunction	structural constituent of nuclear pore	POM121 POM121B	1.20e-03	25	41	2	GO:0017056
GeneOntologyMolecularFunction	nuclear localization sequence binding	POM121 POM121B	1.40e-03	27	41	2	GO:0008139
GeneOntologyMolecularFunction	single-stranded RNA binding	DAZAP1 LARP4 PABPC4	1.53e-03	111	41	3	GO:0003727
GeneOntologyMolecularFunction	poly(A) binding	LARP4 PABPC4	1.61e-03	29	41	2	GO:0008143
GeneOntologyMolecularFunction	poly(U) RNA binding	DAZAP1 PABPC4	2.21e-03	34	41	2	GO:0008266
GeneOntologyMolecularFunction	poly-pyrimidine tract binding	DAZAP1 PABPC4	2.90e-03	39	41	2	GO:0008187
GeneOntologyMolecularFunction	transcription coregulator binding	BSN PER2 RUNX3	2.96e-03	140	41	3	GO:0001221
GeneOntologyMolecularFunction	transcription coactivator activity	NCOA2 TCF20 PER2 MAML3	3.38e-03	303	41	4	GO:0003713
GeneOntologyMolecularFunction	signal sequence binding	POM121 POM121B	4.92e-03	51	41	2	GO:0005048
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	LHX1 TFCP2L1 HIF3A RUNX3 HOXD11 EGR3 NEUROD4 ZBTB4	7.19e-03	1412	41	8	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase binding	PCF11 PER2	7.88e-03	65	41	2	GO:0070063
GeneOntologyCellularComponent	HFE-transferrin receptor complex	TFR2 TFRC	1.04e-04	8	41	2	GO:1990712
MousePheno	absent muscle spindles	RUNX3 EGR3	1.82e-05	3	35	2	MP:0008468
Domain	Peptidase_M28	QPCT FOLH1 TFR2 TFRC	7.94e-09	12	39	4	PF04389
Domain	Peptidase_M28	QPCT FOLH1 TFR2 TFRC	7.94e-09	12	39	4	IPR007484
Domain	TFR_dimer	FOLH1 TFR2 TFRC	1.68e-07	6	39	3	PF04253
Domain	-	FOLH1 TFR2 TFRC	1.68e-07	6	39	3	1.20.930.40
Domain	TFR-like_dimer_dom	FOLH1 TFR2 TFRC	2.93e-07	7	39	3	IPR007365
Domain	PA	FOLH1 TFR2 TFRC	7.97e-06	19	39	3	PF02225
Domain	PA_domain	FOLH1 TFR2 TFRC	7.97e-06	19	39	3	IPR003137
Domain	PAC	NCOA2 HIF3A PER2	2.12e-05	26	39	3	SM00086
Domain	PAC	NCOA2 HIF3A PER2	2.12e-05	26	39	3	IPR001610
Domain	PAS	NCOA2 HIF3A PER2	4.00e-05	32	39	3	SM00091
Domain	PAS	NCOA2 HIF3A PER2	4.82e-05	34	39	3	IPR000014
Domain	PAS	NCOA2 HIF3A PER2	4.82e-05	34	39	3	PS50112
Domain	PAS_fold_3	HIF3A PER2	1.05e-03	23	39	2	IPR013655
Domain	PAS_3	HIF3A PER2	1.05e-03	23	39	2	PF08447
Domain	RRM	RBM12 DAZAP1 LARP4 PABPC4	1.06e-03	217	39	4	SM00360
Domain	PAS	NCOA2 HIF3A	1.24e-03	25	39	2	PF00989
Domain	PAS_fold	NCOA2 HIF3A	1.24e-03	25	39	2	IPR013767
Domain	RRM_dom	RBM12 DAZAP1 LARP4 PABPC4	1.25e-03	227	39	4	IPR000504
Domain	RRM	RBM12 DAZAP1 LARP4 PABPC4	1.31e-03	230	39	4	PS50102
Domain	-	RBM12 DAZAP1 LARP4 PABPC4	1.63e-03	244	39	4	3.30.70.330
Domain	HLH	NCOA2 HIF3A NEUROD4	1.81e-03	116	39	3	SM00353
Domain	BHLH	NCOA2 HIF3A NEUROD4	1.86e-03	117	39	3	PS50888
Domain	bHLH_dom	NCOA2 HIF3A NEUROD4	1.90e-03	118	39	3	IPR011598
Domain	Nucleotide-bd_a/b_plait	RBM12 DAZAP1 LARP4 PABPC4	2.00e-03	258	39	4	IPR012677
Domain	Znf_FYVE_PHD	TCF20 BSN ZBTB4	3.55e-03	147	39	3	IPR011011
Domain	CUB	CUBN TLL1	4.70e-03	49	39	2	PF00431
Domain	CUB	CUBN TLL1	4.89e-03	50	39	2	SM00042
Domain	-	CUBN TLL1	5.27e-03	52	39	2	2.60.120.290
Domain	CUB	CUBN TLL1	5.47e-03	53	39	2	PS01180
Domain	CUB_dom	CUBN TLL1	6.31e-03	57	39	2	IPR000859
Domain	RRM_1	RBM12 DAZAP1 PABPC4	9.27e-03	208	39	3	PF00076
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	PCF11 NCOA2 PRR12 RBM12 POM121 TCF20 DAZAP1 LARP4 MAML3	2.61e-09	457	41	9	32344865
Pubmed	Role of TfR2-Y250X and TfR1- rs3817672 Single Nucleotide Polymorphism on Pathophysiology of Iron Deficiency Anemia.	TFR2 TFRC	1.36e-06	2	41	2	31793267
Pubmed	Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy.	TFR2 TFRC	1.36e-06	2	41	2	15987753
Pubmed	Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer.	TFR2 TFRC	1.36e-06	2	41	2	26549031
Pubmed	A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells.	TFR2 TFRC	1.36e-06	2	41	2	21849092
Pubmed	Heterotypic interactions between transferrin receptor and transferrin receptor 2.	TFR2 TFRC	1.36e-06	2	41	2	12406888
Pubmed	Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus.	LHX1 PER2	1.36e-06	2	41	2	24767996
Pubmed	Immunohistochemical demonstration of transferrin receptor 1 and 2 in human hepatocellular carcinoma tissue.	TFR2 TFRC	1.36e-06	2	41	2	24901155
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	NCOA2 LHX1 TFCP2L1 HIF3A TCF20 PER2 NEUROD4 MAML3	1.51e-06	709	41	8	22988430
Pubmed	HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.	TFR2 TFRC	4.06e-06	3	41	2	17956864
Pubmed	Absence of binding between the human transferrin receptor and the transferrin complex of biological toxic trace element, aluminum, because of an incomplete open/closed form of the complex.	TFR2 TFRC	4.06e-06	3	41	2	19859668
Pubmed	POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.	POM121 POM121B	4.06e-06	3	41	2	30802453
Pubmed	The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.	TFR2 TFRC	4.06e-06	3	41	2	19828835
Pubmed	Stoichiometries of transferrin receptors 1 and 2 in human liver.	TFR2 TFRC	4.06e-06	3	41	2	19819738
Pubmed	t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway.	CRTC1 MAML3	4.06e-06	3	41	2	12539049
Pubmed	Iron-loaded transferrin potentiates erythropoietin effects on erythroblast proliferation and survival: a novel role through transferrin receptors.	TFR2 TFRC	4.06e-06	3	41	2	34077792
Pubmed	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.	POM121 POM121B	4.06e-06	3	41	2	35507432
Pubmed	The Proprioceptive System Regulates Morphologic Restoration of Fractured Bones.	RUNX3 EGR3	4.06e-06	3	41	2	28834742
Pubmed	An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.	LHX1 PER2	4.06e-06	3	41	2	28017605
Pubmed	Transferrin and transferrin receptors update.	TFR2 TFRC	4.06e-06	3	41	2	29969719
Pubmed	Aluminum exposure affects transferrin-dependent and -independent iron uptake by K562 cells.	TFR2 TFRC	4.06e-06	3	41	2	16085060
Pubmed	Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.	TFR2 TFRC	4.06e-06	3	41	2	29388418
Pubmed	Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.	TFR2 TFRC	4.06e-06	3	41	2	16893896
Pubmed	Human transcription factor protein interaction networks.	PCF11 NCOA2 LHX1 PRR12 RBM12 TCF20 LARP4 HOXD11 PABPC4 TFRC	4.65e-06	1429	41	10	35140242
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	NCOA2 LHX1 TFCP2L1 TCF20 PER2 RUNX3 NEUROD4 MAML3	7.24e-06	877	41	8	20211142
Pubmed	Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.	TFR2 TFRC	8.12e-06	4	41	2	11027676
Pubmed	Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.	TFR2 TFRC	8.12e-06	4	41	2	15894659
Pubmed	Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.	POM121 POM121B	8.12e-06	4	41	2	17900573
Pubmed	Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.	TFR2 TFRC	8.12e-06	4	41	2	10638746
Pubmed	Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.	LHX1 TFCP2L1 HOXD11	1.25e-05	38	41	3	27820600
Pubmed	HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.	TFR2 TFRC	1.35e-05	5	41	2	18353247
Pubmed	Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity.	RUNX3 EGR3	1.35e-05	5	41	2	32576830
Pubmed	The Proprioceptive System Masterminds Spinal Alignment: Insight into the Mechanism of Scoliosis.	RUNX3 EGR3	1.35e-05	5	41	2	28829946
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PCF11 NCOA2 PRR12 RBM12 TCF20	1.56e-05	268	41	5	33640491
Pubmed	Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.	LHX1 BSN NEUROD4	1.82e-05	43	41	3	25228773
Pubmed	The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.	TFR2 TFRC	2.03e-05	6	41	2	9465039
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PCF11 PRR12 POM121 POM121B MAML3 ZBTB4	2.32e-05	493	41	6	15368895
Pubmed	A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.	TFR2 TFRC	2.84e-05	7	41	2	18202258
Pubmed	Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion.	TFR2 TFRC	2.84e-05	7	41	2	6641714
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	NCOA2 PRR12 RBM12 DAZAP1	3.13e-05	152	41	4	38360978
Pubmed	Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.	TFR2 TFRC	3.78e-05	8	41	2	7567998
Pubmed	Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.	LHX1 NEUROD4	4.86e-05	9	41	2	17075007
Pubmed	HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside.	LHX1 HOXD11	6.07e-05	10	41	2	16322559
Pubmed	A census of human transcription factors: function, expression and evolution.	TFCP2L1 HIF3A RUNX3 HOXD11 EGR3 NEUROD4 ZBTB4	8.37e-05	908	41	7	19274049
Pubmed	Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.	CUBN FOLH1	8.88e-05	12	41	2	20852008
Pubmed	Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.	RUNX3 HOXD11	8.88e-05	12	41	2	22916278
Pubmed	Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.	TFR2 TFRC	8.88e-05	12	41	2	25352340
Pubmed	Lif Deficiency Leads to Iron Transportation Dysfunction in Ameloblasts.	ENAM TFRC	8.88e-05	12	41	2	34034544
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	PCF11 RBM12 DAZAP1 LARP4 PABPC4	1.03e-04	399	41	5	35987950
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 TCF20 AKAP9 PER2 SEC24C	1.13e-04	407	41	5	12693553
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	AKAP9 LARP4 PABPC4	1.26e-04	82	41	3	30274258
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOA2 PRR12 TCF20	1.31e-04	83	41	3	28794006
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	NCOA2 RBM12 TCF20 DAZAP1	1.31e-04	220	41	4	35785414
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	PCF11 PRR12 TCF20 SEC24C DAZAP1	1.39e-04	425	41	5	24999758
Pubmed	Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.	LHX1 FRAS1	1.41e-04	15	41	2	23064016
Pubmed	Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.	TFR2 TFRC	1.41e-04	15	41	2	26880306
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	POM121 POM121B	1.41e-04	15	41	2	14697343
Pubmed	Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.	NEUROD4 MAML3	1.61e-04	16	41	2	22069191
Pubmed	Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina.	LHX1 NEUROD4	1.61e-04	16	41	2	17301087
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	RPS6KA6 NCOA2 TCF20 BSN	1.64e-04	233	41	4	37704626
Pubmed	Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons.	LHX1 HOXD11	1.82e-04	17	41	2	18065432
Pubmed	The role of Sonic hedgehog of neural origin in thalamic differentiation in the mouse.	LHX1 NEUROD4	2.05e-04	18	41	2	19244520
Pubmed	Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm.	LHX1 HOXD11	2.05e-04	18	41	2	24370450
Pubmed	Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.	NCOA2 HIF3A NEUROD4	2.14e-04	98	41	3	18557763
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	QPCT LARP4 PABPC4 TFRC	2.24e-04	253	41	4	29911972
Pubmed	Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors.	LHX1 NEUROD4	2.29e-04	19	41	2	15363391
Pubmed	Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome.	LHX1 NEUROD4	2.54e-04	20	41	2	19088125
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PCF11 NCOA2 PRR12 RBM12 TCF20 DAZAP1 PABPC4	2.77e-04	1103	41	7	34189442
Pubmed	Onecut1 is essential for horizontal cell genesis and retinal integrity.	LHX1 BSN	2.81e-04	21	41	2	23926259
Pubmed	Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.	PER2 EGR3	2.81e-04	21	41	2	19839995
Pubmed	Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.	LHX1 RUNX3	3.09e-04	22	41	2	22326227
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ENAM QPCT PRR12 FRAS1 PABPC4	3.31e-04	513	41	5	25798074
Pubmed	Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli.	FRAS1 HOXD11	3.38e-04	23	41	2	18787044
Pubmed	A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors.	LHX1 NEUROD4	3.38e-04	23	41	2	18367606
Pubmed	Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.	RUNX3 NEUROD4	3.68e-04	24	41	2	21734270
Pubmed	A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.	CUBN TCF20 HOXD11	3.69e-04	118	41	3	16971476
Pubmed	GDF11 controls the timing of progenitor cell competence in developing retina.	LHX1 NEUROD4	4.00e-04	25	41	2	15976303
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	LHX1 TFCP2L1 RUNX3 HOXD11 EGR3	4.33e-04	544	41	5	28473536
Pubmed	Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.	LHX1 BSN	4.33e-04	26	41	2	32071204
Pubmed	Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.	LHX1 CUBN	5.03e-04	28	41	2	28847650
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	SEC24C DAZAP1 LARP4 PABPC4	5.13e-04	315	41	4	26777405
Pubmed	An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons.	LHX1 NEUROD4	5.39e-04	29	41	2	23652001
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	TCF20 AKAP9 RUNX3 LARP4	5.51e-04	321	41	4	32098917
Pubmed	Suppressor of fused is required to maintain the multipotency of neural progenitor cells in the retina.	LHX1 NEUROD4	5.78e-04	30	41	2	21451052
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	YIPF5 TCF20 PABPC4 TFRC	5.91e-04	327	41	4	15592455
Pubmed	A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype.	RUNX3 EGR3	6.58e-04	32	41	2	30926747
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	PCF11 DAZAP1 PABPC4 TFRC	6.83e-04	340	41	4	24332808
Pubmed	Interaction network of human early embryonic transcription factors.	NCOA2 PRR12 TCF20 TFRC	7.69e-04	351	41	4	38297188
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	FRAS1 TCF20 AKAP9	7.72e-04	152	41	3	34299191
Pubmed	Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).	POM121 POM121B	7.87e-04	35	41	2	11013070
Pubmed	Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.	TFR2 TFRC	7.87e-04	35	41	2	19862010
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	LHX1 TFCP2L1	8.80e-04	37	41	2	22432025
Pubmed	Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay.	LHX1 CUBN	8.80e-04	37	41	2	16319116
Pubmed	In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells.	LHX1 HOXD11	8.80e-04	37	41	2	39178848
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	POM121 POM121B	9.28e-04	38	41	2	12791264
Pubmed	Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.	POM121 POM121B	9.28e-04	38	41	2	11779826
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	PCF11 QPCT SEC24C DAZAP1 PABPC4	9.45e-04	647	41	5	26618866
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	FRAS1 TMC5 BSN LARP4 PABPC4	9.85e-04	653	41	5	33742100
Pubmed	HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.	LHX1 CUBN	1.03e-03	40	41	2	23362348
Interaction	NUP35 interactions	PCF11 NCOA2 PRR12 RBM12 POM121 TCF20 DAZAP1 LARP4 MAML3	1.43e-07	424	41	9	int:NUP35
Interaction	TLE3 interactions	NCOA2 PRR12 RBM12 POM121 TCF20 ANKRD40 ZBTB4	9.69e-06	376	41	7	int:TLE3
Interaction	ALG13 interactions	PCF11 NCOA2 PRR12 RBM12 TCF20	3.36e-05	183	41	5	int:ALG13
GeneFamily	Basic helix-loop-helix proteins	NCOA2 HIF3A NEUROD4	3.10e-04	110	22	3	420
GeneFamily	RNA binding motif containing	RBM12 DAZAP1 PABPC4	2.10e-03	213	22	3	725
CoexpressionAtlas	kidney_e15.5_Podocyte_MafB_top-relative-expression-ranked_500	RPS6KA6 LHX1 FRAS1 TFCP2L1 CUBN HOXD11 TFRC	1.06e-05	412	40	7	gudmap_kidney_e15.5_Podocyte_MafB_500
CoexpressionAtlas	kidney_e15.5_Podocyte_MafB_k-means-cluster#3_top-relative-expression-ranked_500	RPS6KA6 LHX1 HOXD11 TFRC	5.02e-05	108	40	4	gudmap_kidney_e15.5_Podocyte_MafB_k3_500
ToppCell	Control-B_naive-9\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RPS6KA6 C4BPB PIANP TMC5	4.52e-06	120	41	4	62d3a731d36802c9da8674a042a8604cdb86263a
ToppCell	Control-B_naive-9\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RPS6KA6 C4BPB PIANP TMC5	4.98e-06	123	41	4	36d509eae874733f1a4f8189ad3000136ff6425e
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPS6KA6 C4BPB PIANP TMC5	1.12e-05	151	41	4	2314c004434aed9b7fa1ad01c61c43e5ed4a18ce
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LHX1 FRAS1 TFCP2L1 CUBN	2.33e-05	182	41	4	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	FRAS1 CUBN TMC5 TLL1	2.59e-05	187	41	4	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LHX1 FRAS1 TFCP2L1 CUBN	2.59e-05	187	41	4	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RPS6KA6 LHX1 FRAS1 TFCP2L1	2.65e-05	188	41	4	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	ILEUM-inflamed-(5)_Plasma-(5)_IgA_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ENAM CRTC1 AKAP9 PABPC4	2.71e-05	189	41	4	a0634d72bfdd5f93877724ed6480b50a3a046f71
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RPS6KA6 LHX1 FRAS1 TFCP2L1	2.88e-05	192	41	4	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	10x3'2.3-week_12-13-Hematopoietic-erythroid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	HIF3A TMC5 TFR2 TFRC	2.88e-05	192	41	4	6ace9a34ed264583042156ed61c2cb3504a331d2
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 TMC5 PER2 TLL1	3.37e-05	200	41	4	b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Slc17a7-Slc17a6.Calb1-Rorb-Il1rapl2_(Layer_5b)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	FRAS1 EGR3 NEUROD4	5.50e-05	80	41	3	402aba070f0728ebda9db7a8fa85441533755ff4
Drug	bmep	TFR2 TFRC	9.02e-06	3	40	2	CID003081158
Drug	Polylysine	TFR2 TFRC	9.02e-06	3	40	2	CID000162282
Drug	cytochalasin B; Down 200; 20.8uM; MCF7; HT_HG-U133A_EA	PCF11 NCOA2 RBM12 LARP4 EGR3	1.85e-05	187	40	5	1122_DN
Drug	geldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A	PCF11 RBM12 PER2 EGR3 TFRC	2.15e-05	193	40	5	6946_DN
Drug	C6-NBD-SM	TFR2 TFRC	3.00e-05	5	40	2	CID006439924
Disease	glutaminyl-peptide cyclotransferase measurement	QPCT RUNX3	1.79e-05	5	40	2	EFO_0802570
Disease	hematocrit	PRR12 CRTC1 TFCP2L1 TMC5 BSN DAZAP1 HOXD11 TFR2	5.36e-05	1011	40	8	EFO_0004348
Disease	Malignant neoplasm of breast	NCOA2 CUBN AKAP9 PER2 DAZAP1 HOXD11 TLL1 TFRC	8.18e-05	1074	40	8	C0006142
Disease	Cooley's anemia	TFR2 TFRC	1.17e-04	12	40	2	C0002875
Disease	Thalassemia Minor	TFR2 TFRC	1.17e-04	12	40	2	C0085578
Disease	Thalassemia Intermedia	TFR2 TFRC	1.17e-04	12	40	2	C0271979
Disease	beta Thalassemia	TFR2 TFRC	1.17e-04	12	40	2	C0005283
Disease	iron biomarker measurement, transferrin saturation measurement	TFR2 TFRC	1.61e-04	14	40	2	EFO_0004461, EFO_0006333
Disease	cortex volume change measurement	EGR3 SUMF1	1.86e-04	15	40	2	EFO_0021500
Disease	Hemoglobin F Disease	TFR2 TFRC	1.86e-04	15	40	2	C0019025
Disease	transferrin saturation measurement	TFR2 TFRC	2.12e-04	16	40	2	EFO_0006333
Disease	superior temporal gyrus volume measurement	CUBN EGR3	3.02e-04	19	40	2	EFO_0010331
Disease	chronic obstructive pulmonary disease	CRTC1 FRAS1 RUNX3 MAML3 SUMF1 PABPC4	3.07e-04	688	40	6	EFO_0000341
Disease	erythrocyte measurement	BSN LARP4 TFR2 TFRC	4.02e-04	257	40	4	EFO_0005047
Disease	language measurement	HIF3A TCF20 SUMF1	8.00e-04	134	40	3	EFO_0007797
Disease	self rated health	BSN SEC24C	8.13e-04	31	40	2	EFO_0004778
Disease	primary dental caries	CUBN TLL1	9.78e-04	34	40	2	EFO_0600095
Disease	Sclerocystic Ovaries	RUNX3 LARP4 TFRC	9.85e-04	144	40	3	C1136382
Disease	Polycystic Ovary Syndrome	RUNX3 LARP4 TFRC	9.85e-04	144	40	3	C0032460
Disease	gait measurement	CRTC1 MAML3 PABPC4	1.11e-03	150	40	3	EFO_0007680
Disease	Alzheimer disease, polygenic risk score	FRAS1 RSPH6A TCF20 LARP4 PABPC4	1.13e-03	586	40	5	EFO_0030082, MONDO_0004975
Disease	FEV/FEC ratio	PRR12 CRTC1 FRAS1 RSPH6A RUNX3 EGR3 PABPC4	1.19e-03	1228	40	7	EFO_0004713
Disease	cognitive function measurement, self reported educational attainment	PRR12 TCF20 BSN MAML3	1.34e-03	355	40	4	EFO_0004784, EFO_0008354
Disease	immature reticulocyte measurement	TFR2 TFRC	1.35e-03	40	40	2	EFO_0803545
Disease	Hypermetropia, Myopia	NCOA2 CUBN SUMF1	2.15e-03	189	40	3	HP_0000540, HP_0000545
Disease	Chronic Lymphocytic Leukemia	QPCT TFRC	2.54e-03	55	40	2	C0023434
Disease	ovarian cancer (is_implicated_in)	RUNX3 TFRC	2.63e-03	56	40	2	DOID:2394 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FQNRYPGTPADFNPG	AKAP9	3846	Q99996
PGPTQFFYTEEPQGF	AJM1	276	C9J069
GTYAGPAPAFQPFFF	ANKRD40	236	Q6AI12
QGFSDPSQQPPSYGG	DAZAP1	361	Q96EP5
NNGPPFNFPGNFGGS	RBM12	716	Q9NTZ6
GAPNPTFPNFFPNSA	QPCT	251	Q16769
FQPAAGGYFVPAVPQ	PABPC4	401	Q13310
PFFDPTGTIYNEGPQ	FRAS1	3731	Q86XX4
PFNNGASYPLQAGQP	MAML3	981	Q96JK9
PYNVGPGFTGNFSTQ	FOLH1	326	Q04609
TQNGFPAHQAPTYPG	BSN	3071	Q9UPA5
YSFPSGTPNLPQAFF	PER2	911	O15055
GNYDFFPQGPPSSQA	LHX1	291	P48742
LAGYTPFANGPNDTP	RPS6KA6	616	Q9UK32
SYPGANPQPAFGAAE	POM121B	546	A6NF01
SVSFNQTGPYNDPPG	PCF11	1126	O94913
QTGPYNDPPGNAFNA	PCF11	1131	O94913
PSYPGANPQPAFGAA	POM121	961	Q96HA1
LGTFTSPNFPNNYPN	CUBN	1056	O60494
PYAFFTQAGSQQPPP	CRTC1	351	Q6UUV9
PELSYSGSFQPAPGN	EGR3	66	Q06889
QGFDQFYEAAPGPPF	HOXD11	176	P31277
PPGNPVHGYFEGNNF	C4BPB	141	P20851
PFPNGSFVNGFNSPG	LARP4	341	Q71RC2
PFFGNGLPQQFPQYQ	ENAM	76	Q9NRM1
PQAFPPFGNGLFPYQ	ENAM	156	Q9NRM1
PGYQPQQNGSFGPAR	SEC24C	276	P53992
PYPGAPQNQSGPFQA	RUNX3	311	Q13761
NTGFPSEFQPQPYSD	RSPH6A	91	Q9H0K4
SNGNLSSPGFPNGYP	TLL1	356	O43897
NSANPGFLDYGFAAP	PIANP	121	Q8IYJ0
PYSDEDTTQPGGPFQ	HIF3A	646	Q9Y2N7
SSPQLYNFSGAAPGP	PRR12	261	Q9ULL5
PSPSYNGSPNSFGLG	TFCP2L1	271	Q9NZI6
GDPYTPGFPSFNHTQ	TFRC	306	P02786
QGTAPVDAFPPNGYG	SUMF1	276	Q8NBK3
FPPNYGISQQPDPGF	NCOA2	1301	Q15596
GVFGYAVNPQAAPPA	ZBTB4	966	Q9P1Z0
QSYGPPQGSSFGNQY	TCF20	116	Q9UGU0
ASPQPFYGNNFEDEP	YIPF5	76	Q969M3
PDYPGSQRNPDFAGS	TMC5	126	Q6UXY8
GTGDPYTPGFPSFNQ	TFR2	326	Q9UP52
YTPGFPSFNQTQFPP	TFR2	331	Q9UP52
NFNYQSPGLPSPPYG	NEUROD4	201	Q9HD90