Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F	1.37e-08	279	99	12	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D3E TBC1D3 PSD TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F RAPGEFL1	2.04e-07	507	99	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D3E TBC1D3 PSD TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F RAPGEFL1	2.04e-07	507	99	14	GO:0030695
GeneOntologyMolecularFunction	enzyme activator activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I MMP15 TBC1D3G TBC1D3K AGAP2 TBC1D3F	2.13e-05	656	99	13	GO:0008047
GeneOntologyMolecularFunction	enzyme regulator activity	TBC1D3E TBC1D3 PSD TBC1D3H TBC1D3L RARRES1 TBC1D3D TPRN TBC1D3C TBC1D3B EZHIP TBC1D3I MMP15 TBC1D3G TBC1D3K AGAP2 TBC1D3F RAPGEFL1	1.91e-04	1418	99	18	GO:0030234
GeneOntologyMolecularFunction	molecular function activator activity	SEMA6B TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D FBRS TBC1D3C TBC1D3B MAP3K9 TBC1D3I MMP15 TBC1D3G TBC1D3K AGAP2 TBC1D3F	3.56e-04	1233	99	16	GO:0140677
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F	9.67e-14	109	95	12	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F	1.32e-09	244	95	12	GO:0043547
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B RASIP1 TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F	4.58e-09	335	95	13	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F	3.12e-06	499	95	12	GO:0051345
GeneOntologyBiologicalProcess	regulation of hydrolase activity	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B SORT1 RASIP1 TBC1D3I TBC1D3G TBC1D3K AGAP2 TBC1D3F	4.78e-05	878	95	14	GO:0051336
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4X NLGN2	1.38e-04	4	101	2	GO:0098983
HumanPheno	Narrow palm	MKRN3 MAGEL2 KMT2B	4.07e-05	20	18	3	HP:0004283
Domain	TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	5.54e-14	49	96	10	SM00164
Domain	RabGAP-TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.29e-13	53	96	10	PF00566
Domain	TBC_RABGAP	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.92e-13	55	96	10	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.92e-13	55	96	10	IPR000195
Domain	Roc	RHOT2 RABL6 AGAP2	3.63e-05	13	96	3	PF08477
Domain	MIRO-like	RHOT2 RABL6 AGAP2	3.63e-05	13	96	3	IPR013684
Domain	Carboxylesterase_B_CS	CES1 NLGN4X NLGN2	3.63e-05	13	96	3	IPR019819
Domain	CARBOXYLESTERASE_B_2	CES1 NLGN4X NLGN2	4.60e-05	14	96	3	PS00941
Domain	COesterase	CES1 NLGN4X NLGN2	4.60e-05	14	96	3	PF00135
Domain	CarbesteraseB	CES1 NLGN4X NLGN2	4.60e-05	14	96	3	IPR002018
Domain	Nlgn	NLGN4X NLGN2	2.59e-04	5	96	2	IPR000460
Domain	Peptidase_S54_rhomboid	RHBDL1 RHBDD3	7.17e-04	8	96	2	IPR002610
Domain	Rhomboid	RHBDL1 RHBDD3	9.19e-04	9	96	2	PF01694
Domain	Peptidase_S54_rhomboid_dom	RHBDL1 RHBDD3	9.19e-04	9	96	2	IPR022764
Domain	-	RHBDL1 RHBDD3	9.19e-04	9	96	2	1.20.1540.10
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3C TBC1D3B SLC35G3 TBC1D3I TBC1D3G TBC1D3K	1.03e-11	99	60	10	M46448
Pathway	WP_NRXN1_DELETION_SYNDROME	GRIN2D NLGN4X NLGN2	5.72e-05	18	60	3	M48098
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.11e-28	11	105	11	16863688
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D SEPTIN4 RNF222 TBC1D3B RAB34 TBC1D3G TBC1D3F	2.48e-14	74	105	10	16625196
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	TBC1D3 TBC1D3D TBC1D3F	1.07e-07	4	105	3	8406013
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	1.07e-07	4	105	3	12359748
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ATMIN SEMA6B B4GALNT4 KMT2B SPEG FBRS MUS81 RHOT2 GRIN2D ANKHD1 FHIP1B RABL6 TNRC18 CELSR2 TMEM132A NLGN2	2.14e-07	1105	105	16	35748872
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	TBC1D3 TBC1D3D TBC1D3C	2.66e-07	5	105	3	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	TBC1D3 TBC1D3D TBC1D3F	2.66e-07	5	105	3	8471161
Pubmed	Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.	CES1 SORT1	9.03e-06	2	105	2	27881673
Pubmed	Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase.	RHBDL1 RHOT2	2.70e-05	3	105	2	15218247
Pubmed	Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype.	MKRN3 MAGEL2	2.70e-05	3	105	2	10915770
Pubmed	CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort.	SORT1 CELSR2	2.70e-05	3	105	2	24674750
Pubmed	Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.	SORT1 CELSR2	2.70e-05	3	105	2	26464717
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4X NLGN2	2.70e-05	3	105	2	21282647
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	2.70e-05	3	105	2	21030649
Pubmed	Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain.	MKRN3 MAGEL2	5.40e-05	4	105	2	12971993
Pubmed	Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.	SORT1 CELSR2	5.40e-05	4	105	2	21087763
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4X NLGN2	5.40e-05	4	105	2	12669065
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4X NLGN2	5.40e-05	4	105	2	22671294
Pubmed	Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.	SORT1 CELSR2 MTNR1B	6.61e-05	26	105	3	19060910
Pubmed	Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins.	NLGN4X NLGN2	8.97e-05	5	105	2	15620359
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4X NLGN2	8.97e-05	5	105	2	10996085
Pubmed	Retrotransposed genes such as Frat3 in the mouse Chromosome 7C Prader-Willi syndrome region acquire the imprinted status of their insertion site.	MKRN3 MAGEL2	8.97e-05	5	105	2	11845283
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4X NLGN2	8.97e-05	5	105	2	37865312
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN4X NLGN2	1.34e-04	6	105	2	21838267
Pubmed	The rhomboid-like superfamily: molecular mechanisms and biological roles.	RHBDL1 RHBDD3	1.34e-04	6	105	2	25062361
Pubmed	Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.	SORT1 CELSR2	1.34e-04	6	105	2	19299407
Pubmed	Sampling the membrane: function of rhomboid-family proteins.	RHBDL1 RHBDD3	1.34e-04	6	105	2	23369641
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN4X NLGN2	1.34e-04	6	105	2	29724786
Pubmed	The rhomboid protease family: a decade of progress on function and mechanism.	RHBDL1 RHBDD3	1.34e-04	6	105	2	22035660
Pubmed	Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation.	MKRN3 MAGEL2	1.34e-04	6	105	2	18166085
Pubmed	Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line.	H2BC20P H2BC19P	1.34e-04	6	105	2	20194426
Pubmed	Emerging role of rhomboid family proteins in mammalian biology and disease.	RHBDL1 RHBDD3	1.34e-04	6	105	2	23562403
Pubmed	Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.	SORT1 CELSR2	1.88e-04	7	105	2	20031591
Pubmed	Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.	SORT1 CELSR2	1.88e-04	7	105	2	21239051
Pubmed	Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos.	MKRN3 MAGEL2	1.88e-04	7	105	2	25300248
Pubmed	Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.	SORT1 CELSR2 MTNR1B	2.26e-04	39	105	3	21909109
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN4X NLGN2	2.50e-04	8	105	2	30871858
Pubmed	Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation.	MKRN3 MAGEL2	2.50e-04	8	105	2	23819640
Pubmed	Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.	SORT1 CELSR2	3.21e-04	9	105	2	19487539
Pubmed	Binding of neuroligins to PSD-95.	NLGN4X NLGN2	3.21e-04	9	105	2	9278515
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	SHKBP1 SORT1 PTOV1 RAB34 CELSR2 MMP15	3.49e-04	307	105	6	37499664
Pubmed	Prader-Willi Syndrome	MKRN3 MAGEL2	4.00e-04	10	105	2	20301505
Pubmed	The imprinted gene Magel2 regulates normal circadian output.	MKRN3 MAGEL2	4.00e-04	10	105	2	17893678
Pubmed	EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.	EZHIP PHF1	4.00e-04	10	105	2	31451685
Pubmed	Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study.	SORT1 CELSR2	4.88e-04	11	105	2	20570916
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN4X NLGN2	4.88e-04	11	105	2	32973045
Pubmed	CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.	GRIN2D NLGN2	4.88e-04	11	105	2	9647694
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN4X NLGN2	4.88e-04	11	105	2	26403076
Pubmed	Functional characterization of a human histone gene cluster duplication.	H2BC20P H2BC19P	4.88e-04	11	105	2	15527963
Pubmed	The LMO2 oncogene regulates DNA replication in hematopoietic cells.	B4GALNT1 KMT2B POLD1	7.31e-04	58	105	3	26764384
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	CACNA2D2 HCN3	8.02e-04	14	105	2	29107716
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN4X NLGN2	9.24e-04	15	105	2	18227507
Pubmed	Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.	SORT1 CELSR2	1.05e-03	16	105	2	19198609
Pubmed	A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.	SORT1 CELSR2	1.19e-03	17	105	2	21378988
Pubmed	A diverse range of gene products are effectors of the type I interferon antiviral response.	DDIT4 CGAS	1.19e-03	17	105	2	21478870
Pubmed	A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.	SORT1 CELSR2	1.34e-03	18	105	2	20971364
Pubmed	Inhibition of core histones acetylation by carcinogenic nickel(II).	H2BC20P H2BC19P	1.34e-03	18	105	2	16283522
Pubmed	Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.	MKRN3 MAGEL2	1.34e-03	18	105	2	21343540
Pubmed	Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.	H2BC20P H2BC19P	1.34e-03	18	105	2	12757711
Pubmed	Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.	SORT1 CELSR2	1.49e-03	19	105	2	23118302
Pubmed	Additive effect of multiple genetic variants on the risk of coronary artery disease.	SORT1 CELSR2	1.49e-03	19	105	2	20738937
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DDN GRIN2D NLGN4X MAP3K9 AGAP2	1.66e-03	281	105	5	28706196
Pubmed	Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.	MKRN3 MAGEL2	2.39e-03	24	105	2	11668390
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PRR36 HCN3 DDN GRIN2D CELSR2 FAM120C PRRC2C NLGN2 AGAP2	2.59e-03	963	105	9	28671696
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	FBRS ANKHD1 PRR14 RAB34 PRRC2C SUSD2	2.68e-03	457	105	6	32344865
Pubmed	DSCAM Deficiency Leads to Premature Spine Maturation and Autism-like Behaviors.	NLGN4X NLGN2	2.80e-03	26	105	2	34848499
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B SLC35G3 TBC1D3I TBC1D3G TBC1D3K TBC1D3F	1.31e-15	149	105	12	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H TBC1D3C TBC1D3B SLC35G3 TBC1D3F	1.17e-07	99	105	6	17q12
Cytoband	19q13.33	GRIN2D PTOV1 RASIP1 PTH2	1.07e-04	106	105	4	19q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	TPRN CCDC187 LINC02913 STPG3 RABL6	9.34e-04	325	105	5	chr9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	KMT2B POLD1 NFKBID GRIN2D SHKBP1 PTOV1 RASIP1 PTH2 RNF225	1.69e-03	1192	105	9	chr19q13
Cytoband	12q14.1	LINC01465 AGAP2	1.88e-03	28	105	2	12q14.1
Cytoband	9q34.3	TPRN STPG3 RABL6	1.89e-03	106	105	3	9q34.3
Cytoband	17p13.1	RNF222 RNASEK NLGN2	2.56e-03	118	105	3	17p13.1
GeneFamily	Rhomboid family	RHBDL1 RHBDD3	8.08e-04	14	55	2	926
GeneFamily	Beta 4-glycosyltransferases	B4GALNT4 B4GALNT1	1.20e-03	17	55	2	425
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	3.39e-10	90	98	9	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	B4GALNT4 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	1.79e-07	242	98	10	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	6.31e-07	213	98	9	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	6.31e-07	213	98	9	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D NFKBID TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	7.06e-07	281	98	10	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D NFKBID TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F	7.06e-07	281	98	10	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B MMP15 TBC1D3G TBC1D3K TBC1D3F	2.28e-06	320	98	10	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlas	cerebral cortex	MKRN3 SEMA6B ISLR2 B4GALNT4 JPH4 B4GALNT1 MAGEL2 PSD PRR36 SEPTIN4 RHBDL1 DDN GRIN2D SLC4A3 NLGN4X AJAP1 CELSR2 TMEM132A NLGN2 AGAP2	6.82e-06	1428	98	20	cerebral cortex
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D PRR36 FBRS TBC1D3C TBC1D3B PHF1 PRR14 CELSR2 NFATC4 TMEM132A PAN2 TBC1D3G TBC1D3K TBC1D3F	7.84e-06	1075	98	17	PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR2 B4GALNT4 MAGEL2 CACNA2D2 HCN3 AJAP1	4.23e-06	179	105	6	479116ac65488c60104a053530830763ec1f95b2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR2 B4GALNT4 MAGEL2 CACNA2D2 HCN3 AJAP1	4.23e-06	179	105	6	1dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ISLR2 B4GALNT4 MAGEL2 CACNA2D2 HCN3 AJAP1	4.23e-06	179	105	6	69a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MAGEL2 CACNA2D2 HCN3 GRIN2D PRRC2C NECTIN4	4.66e-06	182	105	6	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	B4GALNT4 PSD SLC4A3 AJAP1 TSC22D4 AGAP2	7.99e-06	200	105	6	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	Severe-B_naive-13\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TBC1D3L DDN NFKBID RNF222 IGHD	8.21e-06	116	105	5	f81a7c3e9cbf39124232d98e2a3a3e308137f391
ToppCell	Severe-B_naive-13\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DDIT4 TBC1D3L DDN NFKBID RNF222	9.69e-06	120	105	5	d08edc09de8497714af55a6ca08a447cd71095e7
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBC1D3L DDN NFKBID RNF222 IGHD	2.34e-05	144	105	5	b2a9f3b5dd46d27689467f4a5fd717cd5827821f
Disease	macrophage inflammatory protein 1b measurement	TBC1D3 CACNA2D2 TBC1D3B SLC35G3 TBC1D3F	4.20e-05	136	83	5	EFO_0008219
Disease	sortilin measurement	SORT1 CELSR2	4.67e-05	4	83	2	EFO_0600000
Disease	Prader-Willi syndrome	MKRN3 MAGEL2	3.47e-04	10	83	2	cv:C0032897
Disease	PRADER-WILLI SYNDROME	MKRN3 MAGEL2	3.47e-04	10	83	2	176270
Disease	Royer Syndrome	MKRN3 MAGEL2	5.07e-04	12	83	2	C0265222
Disease	Prader-Willi Syndrome	MKRN3 MAGEL2	5.98e-04	13	83	2	C0032897
Disease	CCL4 measurement	TBC1D3 TBC1D3F	1.44e-03	20	83	2	EFO_0004751
Disease	clinical and behavioural ideal cardiovascular health	CELSR2 MTNR1B	1.90e-03	23	83	2	EFO_0007654
Disease	longitudinal BMI measurement, response to amisulpride	SEMA6B PAK6-AS1	3.02e-03	29	83	2	EFO_0005937, EFO_0010718
Disease	blood vanadium measurement	B4GALNT4 AJAP1	3.23e-03	30	83	2	EFO_0021533
Disease	low density lipoprotein cholesterol measurement, C-reactive protein measurement	RASIP1 CELSR2	4.38e-03	35	83	2	EFO_0004458, EFO_0004611

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAAWGPPEPAPRRPA	CYS1	81	Q717R9
GPLRFTPPQPAEPWS	CES1	61	P23141
FIPPLGSARPFPPWM	SLC4A3	971	P48751
PLERPSPPAQRPWSS	CCDC187	561	A0A096LP49
PGTRRPTSGPPRPLW	CACNA2D2	31	Q9NY47
PLAPWAPPQSPRRPE	B4GALNT1	36	Q00973
SPPRPPRLWSFRSGQ	AJAP1	56	Q9UKB5
RRPLLSSPSWGGPEP	AGAP2	141	Q99490
PLPPGVSGFLPWRTA	CEP78	381	Q5JTW2
WPRTRFGLPAAAPCP	CELSR2	1986	Q9HCU4
GSPQPPPRRPWASRV	DDN	76	O94850
ARCSTKPRPPPGPWD	CGAS	126	Q8N884
PAWPAPPATPRFLAL	ISLR2	321	Q6UXK2
GPARPPWLPARPGAT	RASIP1	496	Q5U651
PRRGTAPTRTAAPPW	RABL6	506	Q3YEC7
PSPPRPEHASWARGP	FHIP1B	466	Q8N612
WPAANSAPAPRRAPP	PAN2	411	Q504Q3
RAWASPSPVPLPPDL	KIAA0100	856	Q14667
FPWPPGAARSPALPY	HELT	176	A6NFD8
RAPPASSRAPPVPWD	MAGEL2	31	Q9UJ55
ARVPEPWVPPSSAPR	JSRP1	156	Q96MG2
SWPSTPCPRAPRRSP	H2BC20P	106	Q6DN03
SWPSTPCPRAPRRSP	H2BC19P	106	Q6DRA6
WPPPQLAASRREAPP	KAAG1	41	Q9UBP8
WRVSAPPSGPPQFPA	NFKBID	6	Q8NI38
PSPRPPGAPESRGLW	KCNK15	261	Q9H427
GPRWPDVARPPFNPH	MMP15	566	P51511
PSPPGRFFLPIPQQW	EZHIP	411	Q86X51
PSSPASSRQPWRPPA	JPH4	461	Q96JJ6
GSARPSRTPRPPWVA	MTNR1B	26	P49286
PSPLAPRPPPSRWAS	KMT2B	1916	Q9UMN6
PRPPPSRWASPPLKT	KMT2B	1921	Q9UMN6
PAPRWTSQPPRPSCA	PABPC1L	431	Q4VXU2
RAGPWASTSRLPAPP	HCN3	661	Q9P1Z3
PRDTGPSVFPPRWDS	LRRC66	661	Q68CR7
SWPASPRGPQPPRIR	PTOV1	36	Q86YD1
AAASGPWVPPGPRLR	ATMIN	31	O43313
EPTWLAAPPRLARPP	FBRS	361	Q9HAH7
PRTPTPDRPPRSAWG	DDIT4	21	Q9NX09
TPPPRAWFLPPACLS	FAM120C	206	Q9NX05
APARPPPQPRSTTFW	IGHD	321	P01880
AWGPPSPELLAPTRF	CTSF	31	Q9UBX1
ALAWPTPPTRPAPAP	B3GNT3	46	Q9Y2A9
PPVLPSTQAPWDPFR	DUXB	211	A0A1W2PPF3
RAQPFAQPPGPWPLS	MCRIP2	46	Q9BUT9
VPGFVPASPWGLRLP	MAN1C1	6	Q9NR34
CSSWNPPLFSPRPLP	LINC02913	21	Q8NAJ2
SPASSPELPWRPRGL	FAM53C	251	Q9NYF3
PPSAIDPRWLRPTPP	POLD1	71	P28340
ARRFQPPEAPASWPG	NLGN2	81	Q8NFZ4
RLPPYATRWPPRPPA	NLGN2	621	Q8NFZ4
ATRWPPRPPAGAPGT	NLGN2	626	Q8NFZ4
RRFQPPEPPSSWTGI	NLGN4X	86	Q8N0W4
LPDPNVVFPPTPRRW	MAP3K9	961	P80192
WDPASPAPTSGPRPR	PHF1	16	O43189
RLDAPPPPAAPLPRW	SORT1	36	Q99523
DWGAPPFRTPPRVPS	SUSD2	391	Q9UGT4
PSPPSAPPSLRWYQR	SLC35G3	16	Q8N808
RGPPSPRVAPSPWAP	PSD	71	A5PKW4
PAPLSPSARPRSPWG	SEPTIN4	96	O43236
PWPRAQPLLRASYPP	TMEM132A	86	Q24JP5
WLRPPPTSPGPQARS	TSC22D4	151	Q9Y3Q8
PAPPFPAAPGPWLRR	TGFBR3L	46	H3BV60
LGSPLPSPRASPRPW	NFATC4	211	Q14934
PSPRASPRPWTPEDP	NFATC4	216	Q14934
FPAAPWGPELPRTVR	RHOT2	336	Q8IXI1
AFRGAPGAPLPWPPA	PRR36	1171	Q9H6K5
PPPSSLLRPRLSPWG	PRR14	231	Q9BWN1
RGPPPSWASEPERPS	PRRC2C	281	Q9Y520
DLRRPPTPAPWPSSG	SHKBP1	676	Q8TBC3
PGPPARFPRPIWSAS	TBC1D3L	391	B9A6J9
RFPRPIWSASPPRAP	TBC1D3L	396	B9A6J9
AVWLRFSPPLPASGP	RHBDL1	356	O75783
GPIWTFPPTIRPSPH	STK25	316	O00506
LWTPPPTPRGSHSPR	RITA1	141	Q96K30
RPAPPPLPVEGTSFW	SOX30	16	O94993
ASPRAPAPRAPWPPF	B4GALNT4	536	Q76KP1
FSPSPNTWGPFPVRP	ANKHD1	1881	Q8IWZ3
RAAPLAPLPAPSPRW	LINC01465	36	Q8N7H1
SFSPPAWPQFPPALR	PAK6-AS1	116	Q8N910
PRRPRGALPPWLSPW	RHBDD3	136	Q9Y3P4
GPWAFPPAVPRSLGL	INPP5J	946	Q15735
PGPPARFPRPIWSAS	TBC1D3B	391	A6NDS4
RFPRPIWSASPPRAP	TBC1D3B	396	A6NDS4
PGPPARFPRPIWSAS	TBC1D3H	391	P0C7X1
RFPRPIWSASPPRAP	TBC1D3H	396	P0C7X1
ATVPPLWPALYPPGR	TNRC18	876	O15417
GLPRPWSPPPTGSLR	SEMA6B	816	Q9H3T3
WSPPPTGSLRRPLGP	SEMA6B	821	Q9H3T3
AARGWAPFPVAPVPA	MKRN3	51	Q13064
RPPPGSPWAPAWTPR	RNF225	251	M0QZC1
RSDSPPAPLRPWVPL	SPEG	416	Q15772
PGPPARFPRPIWSAS	TBC1D3F	391	A6NER0
RFPRPIWSASPPRAP	TBC1D3F	396	A6NER0
FPRPPLGLGAPAWPS	STPG3	336	Q8N7X2
ASSPAWRPPPGQARP	RNF222	111	A6NCQ9
PPGRAWADPATPRPR	PTH2	46	Q96A98
TPPRASPTGTPPRAW	nan	136	Q9UF83
GAPRALPAPSPGWRA	nan	171	Q7L0L9
LPAPSPGWRAWPLPA	nan	176	Q7L0L9
PGPPARFPRPIWSAS	TBC1D3E	391	A0A087X179
RFPRPIWSASPPRAP	TBC1D3E	396	A0A087X179
WPPRTPGGLPVPTYL	SKOR2	471	Q2VWA4
IRWQRPSSPPPFLPA	TPRN	411	Q4KMQ1
GALLPWPAPFFPTPA	PRR29	121	P0C7W0
PGPPARFPRPIWSAS	TBC1D3D	391	A0A087WVF3
RFPRPIWSASPPRAP	TBC1D3D	396	A0A087WVF3
PGPRPLCPPARASWA	RNASEK	6	Q6P5S7
PLTSPPWAPLGAPER	RAPGEFL1	136	Q9UHV5
PGPPARFPRPIWSAS	TBC1D3G	391	Q6DHY5
RFPRPIWSASPPRAP	TBC1D3G	396	Q6DHY5
PGPPARFPRPIWSAS	TBC1D3	391	Q8IZP1
RFPRPIWSASPPRAP	TBC1D3	396	Q8IZP1
PWSGPRGPRPTAPLL	RARRES1	11	P49788
YPWPPPARNRPATLP	nan	141	Q8N6K4
PGPPARFPRPIWSAS	TBC1D3K	391	A0A087X1G2
RFPRPIWSASPPRAP	TBC1D3K	396	A0A087X1G2
PGPPARFPRPIWSAS	TBC1D3I	391	A0A087WXS9
RFPRPIWSASPPRAP	TBC1D3I	396	A0A087WXS9
PGPPARFPRPIWSAS	TBC1D3C	391	Q6IPX1
RFPRPIWSASPPRAP	TBC1D3C	396	Q6IPX1
SPRPRTPVGSPWPRV	RAB34	96	P0DI83
SPRVAPGSARPWPAL	MUS81	171	Q96NY9
WSLSPTRPSPPPLGF	ART1	96	P52961
PAPARWPRSDPESQP	GRIN2D	1056	O15399
PPPSYNWTRLDGPLP	NECTIN4	276	Q96NY8