Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cell surface	FGB LAMP1 ADAM29 INTU CSF2RA DSG2 NTRK2 CLEC12B	2.62e-04	1111	33	8	GO:0009986
Domain	TM_Fragile-X-F-assoc	TMEM185A TMEM185B	1.60e-05	4	31	2	IPR019396
Domain	Tmemb_185A	TMEM185A TMEM185B	1.60e-05	4	31	2	PF10269
Domain	Zip	SLC39A14 SLC39A1	2.40e-04	14	31	2	PF02535
Domain	ZIP	SLC39A14 SLC39A1	2.40e-04	14	31	2	IPR003689
Domain	HEAT	STK36 HTT	2.87e-03	48	31	2	PF02985
Domain	HEAT	STK36 HTT	4.16e-03	58	31	2	IPR000357
Domain	-	STK36 WDFY4 HTT	5.83e-03	222	31	3	1.25.10.10
Domain	ARM-like	STK36 WDFY4 HTT	9.96e-03	270	31	3	IPR011989
Pathway	REACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY	SLC39A14 SLC39A1	4.80e-05	8	19	2	MM15106
Pathway	REACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY	SLC39A14 SLC39A1	7.70e-05	10	19	2	M27361
Pathway	REACTOME_ZINC_TRANSPORTERS	SLC39A14 SLC39A1	9.40e-05	11	19	2	MM15101
Pathway	REACTOME_ZINC_TRANSPORTERS	SLC39A14 SLC39A1	1.79e-04	15	19	2	M832
Pathway	WP_ERK_PATHWAY_IN_HUNTINGTONS_DISEASE	NTRK2 HTT	2.31e-04	17	19	2	M39564
Pathway	REACTOME_METAL_ION_SLC_TRANSPORTERS	SLC39A14 SLC39A1	3.22e-04	20	19	2	MM15077
Pathway	REACTOME_METAL_ION_SLC_TRANSPORTERS	SLC39A14 SLC39A1	4.67e-04	24	19	2	M18795
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	GABRG3 NTRK2 HTT	5.15e-04	119	19	3	M48309
Pathway	WP_ZINC_HOMEOSTASIS	SLC39A14 SLC39A1	1.11e-03	37	19	2	M39377
Pathway	WP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION	GABRG3 NTRK2	1.18e-03	38	19	2	M39854
Pubmed	Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease.	NTRK2 HTT	8.20e-07	2	32	2	24991961
Pubmed	The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.	CYP4Z2P CYP4Z1	8.20e-07	2	32	2	25701119
Pubmed	The competing endogenous RNA network of CYP4Z1 and pseudogene CYP4Z2P exerts an anti-apoptotic function in breast cancer.	CYP4Z2P CYP4Z1	8.20e-07	2	32	2	28236635
Pubmed	A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation.	TMEM185A TMEM185B	8.20e-07	2	32	2	12404111
Pubmed	Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.	CYP4Z2P CYP4Z1	8.20e-07	2	32	2	15059886
Pubmed	Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease.	NTRK2 HTT	2.46e-06	3	32	2	26282324
Pubmed	Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.	NTRK2 HTT	2.46e-06	3	32	2	23598407
Pubmed	Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.	CYP4Z2P CYP4Z1	2.46e-06	3	32	2	30832689
Pubmed	mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.	LAMP1 TPCN2	8.19e-06	5	32	2	23394946
Pubmed	Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.	TMEM185A TMEM185B	8.19e-06	5	32	2	15525354
Pubmed	Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.	NTRK2 HTT	1.23e-05	6	32	2	20442398
Pubmed	Genome-wide association study of bipolar disorder in European American and African American individuals.	DPY19L3 NTRK2	2.29e-05	8	32	2	19488044
Pubmed	Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.	LAMP1 HTT	3.67e-05	10	32	2	28396396
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	GDPD2 TPCN2 SLC39A14 SLC39A1 YIPF3 HTT	3.68e-05	697	32	6	28298427
Pubmed	Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy.	SLC39A14 SLC39A1	8.55e-05	15	32	2	16652366
Pubmed	Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.	LAMP1 NTRK2	8.55e-05	15	32	2	24035762
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	FGB LAMP1 DSG2 NTRK2	8.90e-05	257	32	4	16335952
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	LAMP1 NEPRO URB2 SLC39A14 NUP107 DSG2 YIPF3	9.17e-05	1203	32	7	29180619
Pubmed	Genome-wide Analysis of RARβ Transcriptional Targets in Mouse Striatum Links Retinoic Acid Signaling with Huntington's Disease and Other Neurodegenerative Disorders.	GABRG3 HTT	1.24e-04	18	32	2	27405468
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	TMEM185A TMEM185B HTT	6.66e-04	186	32	3	33637726
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LAMP1 DPY19L3 SLC39A14 SLC39A1 DSG2 HTT	7.02e-04	1201	32	6	35696571
Interaction	TMEM185B interactions	TMEM185A TMEM185B	2.99e-05	6	29	2	int:TMEM185B
Interaction	OPRM1 interactions	URB2 YIPF3 HTT CLEC12B	5.17e-05	144	29	4	int:OPRM1
Interaction	LYN interactions	TMEM185A FAM171A1 LAMP1 SLC39A14 CSF2RA DSG2 HTT	5.66e-05	720	29	7	int:LYN
Interaction	PARD3 interactions	FAM171A1 SLC39A14 DSG2 NTRK2 HTT	6.07e-05	298	29	5	int:PARD3
Interaction	SEPTIN3 interactions	SLC39A14 NTRK2 HTT	1.15e-04	66	29	3	int:SEPTIN3
Interaction	ATP6V0D1 interactions	TMEM185A LAMP1 WDFY4 HTT	1.36e-04	185	29	4	int:ATP6V0D1
Interaction	RHOC interactions	FAM171A1 LAMP1 SLC39A14 TMEM185B DSG2 HTT	1.55e-04	584	29	6	int:RHOC
Interaction	NPC1 interactions	LAMP1 TPCN2 SLC39A1 DSG2 YIPF3	1.55e-04	364	29	5	int:NPC1
Interaction	TRAPPC8 interactions	LAMP1 TPCN2 WDFY4	1.56e-04	73	29	3	int:TRAPPC8
Interaction	CXADR interactions	TMEM185A FAM171A1 LAMP1 DSG2 NTRK2	1.66e-04	369	29	5	int:CXADR
Cytoband	1p33	CYP4Z2P CYP4Z1	2.94e-04	35	33	2	1p33
Cytoband	Ensembl 112 genes in cytogenetic band chr1p33	CYP4Z2P CYP4Z1	8.93e-04	61	33	2	chr1p33
GeneFamily	Cytochrome P450 family 4	CYP4Z2P CYP4Z1	7.16e-04	36	20	2	1003
GeneFamily	Endogenous ligands	FGB HTT	2.78e-02	237	20	2	542
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	TMEM185A FAM171A1 DPY19L3 TPCN2 SLC39A14 YIPF3 HTT	1.48e-05	681	32	7	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	TMEM185A FAM171A1 DPY19L3 TPCN2 SLC39A14 YIPF3 HTT	1.82e-05	703	32	7	MM1055
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL3	GDPD2 LAMP1 DSG2 LMBRD1 ABCA8 NTRK2	6.00e-05	574	32	6	M39056
Disease	10-undecenoate 11:1n1 measurement	CYP4Z2P CYP4Z1	2.24e-05	7	31	2	EFO_0021099
Disease	Manganese Poisoning	SLC39A14 HTT	9.64e-05	14	31	2	C0677050
Disease	Respiratory Hypersensitivity	SLC39A14 SLC39A1	2.44e-04	22	31	2	C0035228
Disease	caudate volume change measurement, age at assessment	UBR3 NTRK2	3.69e-04	27	31	2	EFO_0008007, EFO_0021491
Disease	Child Development Disorders, Specific	WDFY4 NTRK2	4.26e-04	29	31	2	C0085997
Disease	Child Development Deviations	WDFY4 NTRK2	4.26e-04	29	31	2	C0085996
Disease	Developmental Disabilities	WDFY4 NTRK2	4.56e-04	30	31	2	C0008073
Disease	childhood trauma measurement, alcohol consumption measurement	GABRG3 INTU	2.54e-03	71	31	2	EFO_0007878, EFO_0007979

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALKSLSLSLLLHCIM	URB2	536	Q14146
MKMLLLLHCLGVFLS	ADAM29	1	Q9UKF5
AHPFLLLILLCMSLL	CYP4Z2P	11	Q8N1L4
LGKLLLHLFMVLCLT	DPY19L3	341	Q6ZPD9
KLCLPMLCFLLHTIL	NUP107	851	P57740
LLVPLLLLMCHCGKG	DSG2	626	Q14126
GGMAFILLVLLCLLL	FAM171A1	311	Q5VUB5
LFLCMILLLIVLHTS	LMBRD1	411	Q9NUN5
KHLLLLLLCVFLVKS	FGB	16	P02675
LHSLHKVLLLLIMLL	GDPD2	116	Q9HCC8
VLGKLLMLFELIHGL	OOSP4A	6	A0A2R8YFL7
LLVVGLKHYMLCVLL	INTU	591	Q9ULD6
LGTLLMCLIHIFKSG	HTT	1776	P42858
MAPKLLLLLCLFSGL	GABRG3	1	Q99928
LLLLLLLLLLGLMHC	LAMP1	11	P11279
MKLLLLHPAFQSCLL	SLC39A14	1	Q15043
MLLLVTSLLLCELPH	CSF2RA	1	P15509
FKAMLIAVGIHLLLL	TMEM185A	81	Q8NFB2
FKAMLIAVGIHLLLL	TMEM185B	81	Q9H7F4
LMKVLGACKLLLRLL	NEPRO	136	Q6NW34
LMSILKHLLCPSFLN	STK36	951	Q9NRP7
KALLALLLILMAGFC	ABCA8	861	O94911
HAALGLVTLCLMLLI	CLEC12B	41	Q2HXU8
AHPFLLLILLCMSLL	CYP4Z1	11	Q86W10
CLLVMLFLLKLARHS	NTRK2	446	Q16620
FLSCLHGLMLVALLL	TMEM270	131	Q6UE05
RAMELCLALLLHKGI	SLC39A1	206	Q9NY26
AGCLLNKMLLSLHLC	SERINC4	251	A6NH21
NISFLLCLMHCLLLL	WDFY4	2056	Q6ZS81
LLCGTLAALHMLFLL	YIPF3	276	Q9GZM5
LMRLLHCKTLHIVLF	UBR3	916	Q6ZT12
ILYLLLALMLCHALF	TMEM239	111	Q8WW34
MASVGLLLAIHLCLF	TPCN2	216	Q8NHX9