Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	adenylate cyclase-activating G protein-coupled receptor signaling pathway	DRD5 ADGRB3 ADORA2B GPR157 SCTR LPAR2 GNAL GNAS	5.24e-06	191	103	8	GO:0007189
GeneOntologyBiologicalProcess	activation of adenylate cyclase activity	DRD5 ADORA2B GNAL GNAS	2.42e-05	34	103	4	GO:0007190
GeneOntologyBiologicalProcess	adenylate cyclase-activating dopamine receptor signaling pathway	DRD5 GNAL GNAS	3.34e-05	13	103	3	GO:0007191
GeneOntologyBiologicalProcess	positive regulation of adenylate cyclase activity	DRD5 ADORA2B GNAL GNAS	4.67e-05	40	103	4	GO:0045762
GeneOntologyBiologicalProcess	G protein-coupled dopamine receptor signaling pathway	DRD5 GNAL GNAS HTT	6.83e-05	44	103	4	GO:0007212
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	DRD5 ADGRB3 ADORA2B GPR157 SCTR LPAR2 GNAL GNAS	9.44e-05	286	103	8	GO:0007188
GeneOntologyBiologicalProcess	positive regulation of cyclase activity	DRD5 ADORA2B GNAL GNAS	9.64e-05	48	103	4	GO:0031281
GeneOntologyBiologicalProcess	positive regulation of lyase activity	DRD5 ADORA2B GNAL GNAS	1.05e-04	49	103	4	GO:0051349
Domain	ARM-type_fold	DOCK1 USP34 SMG1 TRPC4AP UBR4 ARFGEF1 NCDN ARMC1 FHOD1 HTT	1.27e-05	339	99	10	IPR016024
Domain	Gprotein_alpha_S	GNAL GNAS	2.78e-05	2	99	2	IPR000367
Domain	RBM39_linker	RBM23 RBM39	2.78e-05	2	99	2	IPR029123
Domain	RBM39_SF	RBM23 RBM39	2.78e-05	2	99	2	IPR006509
Domain	RBM39linker	RBM23 RBM39	2.78e-05	2	99	2	PF15519
Domain	EPL1	JADE3 JADE2	7.63e-04	8	99	2	PF10513
Domain	Enhancer_polycomb-like_N	JADE3 JADE2	7.63e-04	8	99	2	IPR019542
Domain	Hydrolase_3	ATP10B ATP2B2	1.22e-03	10	99	2	PF08282
Domain	GPCR_2_extracellular_dom	ADGRB3 GPR157 SCTR	1.24e-03	40	99	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_1	ADGRB3 GPR157 SCTR	1.24e-03	40	99	3	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRB3 GPR157 SCTR	1.24e-03	40	99	3	PS50227
Domain	FAD-dep_OxRdtase	GPD2 SARDH	1.77e-03	12	99	2	IPR006076
Domain	DAO	GPD2 SARDH	1.77e-03	12	99	2	PF01266
Domain	-	ACOX2 ACAD11	2.09e-03	13	99	2	1.10.540.10
Domain	AcylCoA_DH/ox_N	ACOX2 ACAD11	2.09e-03	13	99	2	IPR013786
Domain	7tm_2	ADGRB3 GPR157 SCTR	2.36e-03	50	99	3	PF00002
Domain	G_PROTEIN_RECEP_F2_2	ADGRB3 GPR157 SCTR	2.36e-03	50	99	3	PS00650
Domain	CNH	CIT MAP4K2	2.43e-03	14	99	2	SM00036
Domain	Acyl-CoA_Oxase/DH_cen-dom	ACOX2 ACAD11	2.79e-03	15	99	2	IPR006091
Domain	AcylCoA_DH/oxidase_NM_dom	ACOX2 ACAD11	2.79e-03	15	99	2	IPR009100
Domain	Acyl-CoA_dh_M	ACOX2 ACAD11	2.79e-03	15	99	2	PF02770
Domain	CNH	CIT MAP4K2	2.79e-03	15	99	2	PF00780
Domain	CNH	CIT MAP4K2	2.79e-03	15	99	2	PS50219
Domain	CNH_dom	CIT MAP4K2	2.79e-03	15	99	2	IPR001180
Domain	GproteinA_insert	GNAL GNAS	3.18e-03	16	99	2	IPR011025
Domain	-	GNAL GNAS	3.18e-03	16	99	2	1.10.400.10
Domain	G-alpha	GNAL GNAS	3.18e-03	16	99	2	PF00503
Domain	G_alpha	GNAL GNAS	3.18e-03	16	99	2	SM00275
Domain	AcylCo_DH/oxidase_C	ACOX2 ACAD11	3.18e-03	16	99	2	IPR009075
Domain	Gprotein_alpha_su	GNAL GNAS	3.59e-03	17	99	2	IPR001019
Domain	GPCR_2_secretin-like	ADGRB3 GPR157 SCTR	3.97e-03	60	99	3	IPR000832
Domain	GPCR_2-like	ADGRB3 GPR157 SCTR	3.97e-03	60	99	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRB3 GPR157 SCTR	4.16e-03	61	99	3	PS50261
Domain	P-loop_NTPase	MYH4 GNL3L ABCF3 GAL3ST1 NVL NLRP6 SMARCA1 SMARCA4 GNAL GNAS DNAH11	5.24e-03	848	99	11	IPR027417
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 SPIRE2 TMEM8B WWP1 ARHGAP26 NICN1 UBR4 HECTD4 OBSCN APEH SPATA20 CIT SUGP2 PROM2 HTT HR	1.87e-07	1105	104	16	35748872
Pubmed	Defining the membrane proteome of NK cells.	GNL3L ABCF3 AUP1 UBR4 NVL CIT RBM23 NCDN APH1A PLXNC1 FHOD1 DHCR24 SMARCA4 NUP93 EXOC2 GNAS	3.92e-07	1168	104	16	19946888
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP34 SMG1 JADE3 JADE2 ARHGAP26 SNX17 HECTD4 ADGRB3 KBTBD2 DHCR24 NUP93	5.67e-07	529	104	11	14621295
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 MYD88 TRPC4AP GNL3L JADE2 TMEM8B WWP1 HECTD4 OBSCN RBM39 NCDN SUGP2 PROM2 GNAS PBX2 HTT ZNF44	2.01e-06	1489	104	17	28611215
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	GPD2 MYD88 TRAF2 ABCF3 PPM1D CYP11A1 ARHGAP26 RBM23 RBM39 ARMC1 GNAS SEC63	2.35e-06	742	104	12	26871637
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GPD2 TRAF2 GNL3L NRDC AUP1 UBR4 RBM39 NDUFS2 DHCR24 SMARCA1 SMARCA4 HADHA NUP93 GNAS SEC63 NXF1	5.14e-06	1425	104	16	30948266
Pubmed	TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1.	TRAF2 TRPC4AP	8.86e-06	2	104	2	16876162
Pubmed	Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.	MYD88 PDE6B	8.86e-06	2	104	2	25725353
Pubmed	Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling.	MYD88 ADORA2B	8.86e-06	2	104	2	36374941
Pubmed	Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5.	DRD5 PDE6B HTT	9.23e-06	14	104	3	7919654
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TRAF2 GNL3L ABCF3 AUP1 SNX17 UBR4 RBM39 SUGP2 FHOD1 SMARCA1 SMARCA4 HADHA NUP93 EXOC2 NXF1	1.21e-05	1353	104	15	29467282
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	GPD2 USP34 GAL3ST1 WWP1 SNX17 ARFGEF1 NDUFS2 SIRT3 NLN APH1A DHCR24 GNAL NUP93	1.73e-05	1061	104	13	33845483
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	GPD2 USP34 SMG1 GNL3L AUP1 JADE2 UBR4 RBM39 NDUFS2 DHCR24 HADHA NUP93 EXOC2 GNAS SEC63	2.51e-05	1440	104	15	30833792
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	GNL3L AUP1 UBR4 ARFGEF1 NDUFS2 NCDN APH1A PTPRK DHCR24 HADHA NUP93 SEC63	2.56e-05	942	104	12	31073040
Pubmed	Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.	JADE3 JADE2	2.65e-05	3	104	2	14612400
Pubmed	Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.	CYP11A1 SIRT3	2.65e-05	3	104	2	22585829
Pubmed	Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor.	GNAL GNAS	2.65e-05	3	104	2	21467038
Pubmed	Brefeldin A-Inhibited Guanine Nucleotide-Exchange Factor 1 (BIG1) Governs the Recruitment of Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) to Tumor Necrosis Factor Receptor 1 (TNFR1) Signaling Complexes.	TRAF2 ARFGEF1	2.65e-05	3	104	2	27834853
Pubmed	Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.	DRD5 GNAS	2.65e-05	3	104	2	9603210
Pubmed	Rod and cone degeneration in the rd mouse is p53 independent.	PDE6B HTT	2.65e-05	3	104	2	11344337
Pubmed	The enzyme activity of mitochondrial trifunctional protein is not altered by lysine acetylation or lysine succinylation.	SIRT3 HADHA	2.65e-05	3	104	2	34644302
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	AUP1 UBR4 ARFGEF1 NDUFS2 NCDN GGCX DHCR24 SMARCA4 NUP93 SEC63	2.87e-05	657	104	10	36180527
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 TRAF2 TRPM7 JADE2 UBR4 HECTD4 DEF8 ADGRB3 APEH CIT PTPRK SMARCA4 PBX2 QTRT1	2.95e-05	1285	104	14	35914814
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	MYD88 USP34 SMG1 MYH4 PPM1D ATP10B KCNK12 NLN GNAL SEC63 ATP2B2	4.07e-05	832	104	11	36724073
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	OBSCN SMARCA4 DNAH11	4.40e-05	23	104	3	29768498
Pubmed	Pulmonary surfactant protein a is expressed in mouse retina by Müller cells and impacts neovascularization in oxygen-induced retinopathy.	MYD88 PDE6B	5.29e-05	4	104	2	25406276
Pubmed	Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons.	GNAL GNAS	5.29e-05	4	104	2	24034253
Pubmed	Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38.	TRAF2 MAP4K2	5.29e-05	4	104	2	9712898
Pubmed	Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.	TRAF2 MAP4K2	5.29e-05	4	104	2	11784851
Pubmed	Golf: an olfactory neuron specific-G protein involved in odorant signal transduction.	GNAL GNAS	5.29e-05	4	104	2	2499043
Pubmed	Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.	DRD5 ADORA2B SCTR GNAS	5.94e-05	70	104	4	12036966
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK1 ABCF3 PPM1D RBM39 FHOD1 SMARCA4 NUP93 EXOC2 GNAS	6.49e-05	582	104	9	20467437
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	SMG1 NCDN EXOC2	7.21e-05	27	104	3	23027611
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	GNL3L SNX17 NVL RBM39 SUGP2 SMARCA4 NXF1	7.43e-05	339	104	7	30415952
Pubmed	Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo.	DRD5 PDE6B	8.80e-05	5	104	2	20038975
Pubmed	A novel Gαs-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.	GNAL GNAS	8.80e-05	5	104	2	23994616
Pubmed	Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.	RBM23 RBM39	8.80e-05	5	104	2	31686031
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GNL3L CIT RBM39 NDUFS2 FHOD1 SMARCA1 SMARCA4 HADHA NUP93 GNAS SEC63 C9 NXF1	9.79e-05	1257	104	13	36526897
Pubmed	An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies.	ADGRB3 SLC5A5 SCTR ATP2B2	1.21e-04	84	104	4	15123239
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SMG1 TRAF2 TRPC4AP AUP1 ARHGAP26 UBR4 NDUFS2 ACAD11 DNAH11	1.30e-04	638	104	9	31182584
Pubmed	Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin.	MYD88 PLXNC1	1.32e-04	6	104	2	22198947
Pubmed	Epidermal EGFR controls cutaneous host defense and prevents inflammation.	MYD88 HR	1.32e-04	6	104	2	23966300
Pubmed	Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene.	SMARCA1 SMARCA4	1.32e-04	6	104	2	15347669
Pubmed	Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta.	RBM23 RBM39	1.32e-04	6	104	2	15694343
Pubmed	A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli.	MYD88 ADORA2B	1.32e-04	6	104	2	17525287
Pubmed	D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum.	GNAL GNAS	1.32e-04	6	104	2	17194762
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	UBR4 SMARCA1 SMARCA4	1.33e-04	33	104	3	33567268
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	GPD2 TRPM7 AUP1 SNX17 DEF8 ARFGEF1 GGCX SEC63	1.40e-04	504	104	8	34432599
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 UBR4 NVL RBM39 SUGP2 SMARCA4 HADHA NUP93 NXF1	1.55e-04	653	104	9	22586326
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	USP34 TRPC4AP NRDC AUP1 ARHGAP26 UBR4 ACAD11 PTPRK NUP93 GNAS SEC63	1.64e-04	974	104	11	28675297
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	RBM39 SIRT3 SUGP2 SMARCA4 HADHA NXF1	1.80e-04	274	104	6	34244482
Pubmed	Target genes of the largest human SWI/SNF complex subunit control cell growth.	SMARCA1 SMARCA4	1.84e-04	7	104	2	21118156
Pubmed	Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.	MYD88 TRAF2	1.84e-04	7	104	2	27716849
Pubmed	Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.	SIRT3 HTT	1.84e-04	7	104	2	22956852
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	GPD2 ABCF3 AUP1 UBR4 ARFGEF1 APEH RBM39 NDUFS2 NLN HADHA NUP93 GNAS NXF1	2.23e-04	1367	104	13	32687490
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	DOCK1 GPD2 HECTD4 ARFGEF1 EXOC2	2.30e-04	183	104	5	31932471
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	DOCK1 SNX17 SMARCA4 DNAH11	2.37e-04	100	104	4	25807483
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	GNL3L NVL ACAD11 SUGP2 SMARCA1 SMARCA4 PBX2	2.43e-04	411	104	7	35182466
Pubmed	TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.	TRAF2 TRPC4AP	2.45e-04	8	104	2	14585990
Pubmed	RNA association and nucleocytoplasmic shuttling by ataxin-1.	NXF1 HTT	2.45e-04	8	104	2	15615787
Pubmed	Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway.	TRAF2 FBXL21P	2.45e-04	8	104	2	25225294
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	SMG1 NRDC ARFGEF1 SMARCA4 HTT	2.48e-04	186	104	5	33637726
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	SMG1 ARHGAP26 NVL CPZ SUGP2 GNAS DNAH11 ZNF44	2.60e-04	552	104	8	10737800
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	ARFGEF1 FHOD1 EXOC2 HTT	2.76e-04	104	104	4	31240132
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	GPD2 NRDC NDUFS2 NCDN DHCR24 HADHA NUP93 EXOC2	2.86e-04	560	104	8	35241646
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	UBR4 CIT RBM39 NCDN ACAD11 SUGP2	2.93e-04	300	104	6	28561026
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	GPD2 NRDC CYP11A1 GCSH NDUFS2 SIRT3 ARMC1 NLN ACAD11 HADHA SARDH	3.04e-04	1047	104	11	18614015
Pubmed	IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.	MYD88 TRAF2	3.14e-04	9	104	2	23453969
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	GNL3L TRPM7 AUP1 WWP1 SNX17 ARFGEF1 PROM2 PLXNC1	3.18e-04	569	104	8	30639242
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	AUP1 RBM39 NDUFS2 GGCX DHCR24 SMARCA1 HADHA NUP93 NXF1	3.34e-04	725	104	9	27025967
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMG1 HECTD4 NVL RBM39 SMARCA4 NUP93 NXF1	3.66e-04	440	104	7	34244565
Pubmed	Depletion of Ric-8B leads to reduced mTORC2 activity.	GNAL GNAS	3.92e-04	10	104	2	32392211
Pubmed	The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.	MYD88 TRAF2	3.92e-04	10	104	2	20676093
Pubmed	UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination.	MYD88 TRAF2	3.92e-04	10	104	2	23381138
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	TRAF2 AUP1 NDUFS2 ACAD11 ATP2B2	4.24e-04	209	104	5	26389662
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	USP34 UBR4 PCDHB10 CIT RBM39 GNAS	4.26e-04	322	104	6	26514267
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	AUP1 NCDN DHCR24 SMARCA4 GNAS	4.53e-04	212	104	5	33462405
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	USP34 TRAF2 NRDC UBR4 SUGP2	4.53e-04	212	104	5	33853758
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	GPD2 NRDC CYP11A1 NDUFS2 SIRT3 ARMC1 NLN ACAD11 HADHA SARDH	4.66e-04	926	104	10	20877624
Pubmed	SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.	AUP1 NDUFS2 DHCR24 HADHA	4.75e-04	120	104	4	37929963
Pubmed	Therapeutic responses to Roseomonas mucosa in atopic dermatitis may involve lipid-mediated TNF-related epithelial repair.	MYD88 PDE6B	4.79e-04	11	104	2	32908007
Pubmed	IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.	MYD88 NLRP6	4.79e-04	11	104	2	23075849
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP34 TRAF2 GNL3L WWP1 BACH2 GGCX ACAD11 SUGP2 SMARCA1 SMARCA4 TAF4B	5.19e-04	1116	104	11	31753913
Pubmed	Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.	GNAL GNAS	5.73e-04	12	104	2	2508088
Pubmed	Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components.	MYD88 TRAF2	5.73e-04	12	104	2	24735611
Pubmed	Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism.	NRDC CYP11A1 FHOD1	5.77e-04	54	104	3	25464930
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	GPD2 CYP11A1 SPATA20 GCSH NDUFS2 SIRT3 ARMC1 NLN HADHA SARDH QTRT1	6.01e-04	1136	104	11	34800366
Pubmed	Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.	NRDC CIT PREX2 CASD1 HADHA	6.05e-04	226	104	5	37839992
Pubmed	Foxl2 functions in sex determination and histogenesis throughout mouse ovary development.	CYP11A1 GRIP1 PLXNC1	6.09e-04	55	104	3	19538736
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	USP34 SMG1 RBM39 NDUFS2 NCDN ACAD11 HADHA GNAS SEC63 NXF1	6.73e-04	971	104	10	33306668
Pubmed	DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities.	GPD2 HR	6.76e-04	13	104	2	36166296
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK1 ADGRB3	6.76e-04	13	104	2	21930703
Pubmed	The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.	MYD88 NLRP6	6.76e-04	13	104	2	32758418
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	TRPC4AP NSL1 RBM39 NCDN PRICKLE3 SMARCA4 HADHA GNAL NUP93 GNAS NXF1	6.89e-04	1155	104	11	20360068
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SMG1 UBR4 APEH GRIP1 SUGP2 GNAL NXF1	7.61e-04	498	104	7	36634849
Pubmed	Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.	TRPM7 WWP1 ADGRB3	7.85e-04	60	104	3	32027825
Pubmed	XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.	MYD88 TRAF2	7.87e-04	14	104	2	28723569
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	GNL3L RBM23 GGCX ACAD11 SUGP2 SMARCA1 SMARCA4 HADHA NUP93 GNAS SEC63 NXF1	8.20e-04	1371	104	12	36244648
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	UBR4 NVL RBM39 SMARCA1 SMARCA4 HADHA NUP93 GNAS	8.83e-04	665	104	8	30457570
Pubmed	A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.	MYD88 NLRP6	9.07e-04	15	104	2	27339979
Interaction	GNAL interactions	DOCK1 ARHGAP26 GNAL GNAS HTT	1.15e-06	37	102	5	int:GNAL
Interaction	SPOPL interactions	MYD88 PDE6B ARHGAP26 GNAL GNAS	1.15e-06	37	102	5	int:SPOPL
Cytoband	Ensembl 112 genes in cytogenetic band chr8q13	ARFGEF1 PREX2 ARMC1	7.04e-04	76	104	3	chr8q13
Cytoband	Xp11.23	JADE3 KCND1 PRICKLE3	1.34e-03	95	104	3	Xp11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	DRD5 PDE6B CPZ HTT	1.68e-03	222	104	4	chr4p16
Cytoband	5q31	ARHGAP26 PCDHB10 FBXL21P	2.32e-03	115	104	3	5q31
Cytoband	16p12.3	SMG1 TMC7	2.72e-03	34	104	2	16p12.3
Cytoband	20q11.22	TRPC4AP RBM39	3.21e-03	37	104	2	20q11.22
Cytoband	11p15	NLRP6 OR51B2	4.32e-03	43	104	2	11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	JADE2 ARHGAP26 PCDHB10 FBXL21P	4.81e-03	298	104	4	chr5q31
Coexpression	DESCARTES_MAIN_FETAL_CLC_IL5RA_POSITIVE_CELLS	NICN1 NSL1 GCSH THAP9 NDUFS2 SLC5A5 C9 NXF1	7.82e-06	253	104	8	M40110
Coexpression	GSE13411_IGM_MEMORY_BCELL_VS_PLASMA_CELL_UP	MYD88 JADE3 JADE2 BACH2 SNX17 KBTBD2 PTPRK	1.44e-05	198	104	7	M3249
Disease	multiple sclerosis	JADE2 TMEM8B ARHGAP26 BACH2 NSL1 PTPRK PLXNC1 SMARCA4 EXOC2	1.40e-04	594	96	9	MONDO_0005301
Disease	suntan	SPIRE2 TRPC4AP DEF8 EXOC2	3.64e-04	103	96	4	EFO_0004279
Disease	central nervous system non-hodgkin lymphoma	BACH2 EXOC2	3.72e-04	9	96	2	MONDO_0044887
Disease	basal cell carcinoma	SPIRE2 TRPC4AP BACH2 DEF8 EXOC2	3.90e-04	189	96	5	EFO_0004193
Disease	alcohol use disorder (implicated_via_orthology)	DRD5 NDUFS2 SMARCA4 MAP4K2 HR	4.50e-04	195	96	5	DOID:1574 (implicated_via_orthology)
Disease	Coffin-Siris syndrome	SMARCA1 SMARCA4	7.98e-04	13	96	2	C0265338
Disease	squamous cell carcinoma	BACH2 DEF8 DNAH11	1.37e-03	67	96	3	EFO_0000707
Disease	blood metabolite measurement	EXOC2 SARDH	1.73e-03	19	96	2	EFO_0005664
Disease	polycystic kidney disease (biomarker_via_orthology)	GNAS C9	1.73e-03	19	96	2	DOID:0080322 (biomarker_via_orthology)
Disease	coronary artery disease	TRPC4AP TRPM7 ARHGAP26 HECTD4 SIRT3 GGCX ACAD11 SMARCA4 SEC63 PBX2 DNASE1L1	1.73e-03	1194	96	11	EFO_0001645
Disease	behavioural disinhibition measurement	ADGRB3 GNAL DNAH11	1.90e-03	75	96	3	EFO_0006946
Disease	Infiltrating duct carcinoma of female breast	SMG1 TRPM7	2.11e-03	21	96	2	C3165106
Disease	hepatitis B (is_marker_for)	MYD88 PREX2	2.11e-03	21	96	2	DOID:2043 (is_marker_for)
Disease	cholangiocarcinoma (is_implicated_in)	PREX2 GNAS	2.32e-03	22	96	2	DOID:4947 (is_implicated_in)
Disease	renal system measurement, blood urea nitrogen measurement	HECTD4 GNAS	2.32e-03	22	96	2	EFO_0004741, EFO_0004742
Disease	frailty measurement	HTT HR	2.53e-03	23	96	2	EFO_0009885
Disease	Intrahepatic Cholangiocarcinoma	SLC5A5 GNAS	2.76e-03	24	96	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	SLC5A5 GNAS	2.76e-03	24	96	2	C3805278
Disease	Cholangiocarcinoma	SLC5A5 GNAS	3.24e-03	26	96	2	C0206698

Protein segments in the cluster

Peptide	Gene	Start	Entry
KACVIAMRYSVIRRQ	ACOX2	311	Q99424
IREVIRCAEFLRMHN	BACH2	106	Q9BYV9
VILRVSRYDRTIQCM	CEACAM18	191	A8MTB9
FLVACRQLQRTELMD	ADORA2B	206	P29275
FVIVMVHCILRREVQ	ADGRB3	1141	O60242
RNRSPTIRDMVVRCI	ARFGEF1	1246	Q9Y6D6
TVAVRTEAVMRRHCR	C20orf204	126	A0A1B0GTL2
IRAVCQRMYNTLRLA	ABCF3	61	Q9NUQ8
FQMAVQRCVVRIRSD	ARMC1	176	Q9NVT9
YRDRIQMASTRLRLC	CFAP46	461	Q8IYW2
EDAMQHVCRISRILR	DNAH11	2831	Q96DT5
FQECERMNILIREIR	DNAH11	4286	Q96DT5
QFECRVRELQRMLDT	CIT	1056	O14578
AIRKCQRAGITVRMV	ATP2B2	716	Q01814
RRMNIDIFFCIGILI	ATP10B	311	O94823
ALQIMCERATQRIAF	ACAD11	646	Q709F0
VAFLFRMERLRCHAV	NUP93	476	Q8N1F7
RTVFCMQLAARIRPR	RBM23	166	Q86U06
DARTVFCMQLAARIR	RBM39	151	Q14498
VCAAIVRSRHLRANM	DRD5	61	P21918
LVREASICALRQEMA	NVL	796	O15381
LVSFERCVRIVNMQG	MAP4K2	716	Q12851
FRVRCTSKRAVTEML	NSL1	36	Q96IY1
CEAVMILRSRFLDAR	PBX2	231	P40425
RCRFLRSVMSLIDVV	KCND1	256	Q9NSA2
CTAVDMISRRTRLAF	GPD2	546	P43304
YVRRRVQRMAEHVSC	LPAR2	211	Q9HBW0
LVELARANRLCREAM	NCDN	691	Q9UBB6
RSLLCRRQEDSRVMV	APH1A	241	Q96BI3
DAQRIRRFLQMVCPA	HR	1061	O43593
LERVRNLCYMVTRRE	JADE2	476	Q9NQC1
TALCLFRMSEIQARA	PLXNC1	326	O60486
QDLILDLRVRCVMAT	EXOC2	576	Q96KP1
ERIISLLAFIMRACR	KCNK12	166	Q9HB15
LLAFIMRACRERQLR	KCNK12	171	Q9HB15
VLNRRSCMAATLRII	NXF1	246	Q9UBU9
VITRAFCLHQEIMRL	OR51B2	171	Q9Y5P1
EIMRLACADITFNRL	OR51B2	181	Q9Y5P1
NMERVVFKVLRRLCT	PDE6B	71	P35913
RAVVISNSLCVFMRE	KBTBD2	526	Q8IY47
LIEKRCRRMVVVVSD	MYD88	211	Q99836
MALRVVRSVRALLCT	GCSH	1	P23434
RMLRADNTSAIVICI	PPM1D	361	O15297
MAVRELCFPRQRQVL	PCDHB10	1	Q9UN67
MAVVRLLAEIRTRAC	HECTD4	1851	Q9Y4D8
LLAEIRTRACLVMAQ	HECTD4	1856	Q9Y4D8
AVVEVQCERLRMLYR	HECTD4	1906	Q9Y4D8
LCRVEEMRQSLRIIA	NDUFS2	331	O75306
VSLRCAGRLRNMSFV	OSCAR	146	Q8IYS5
RVFNDCRDIIQRMHL	GNAL	361	P38405
VRMEAVGCTRRLVVQ	OBSCN	1396	Q5VST9
ERIMCRLISDFQRHS	PRICKLE3	66	O43900
VAALRHANERMRTIC	GAL3ST1	331	Q99999
FRVLARMVDILACRR	HTT	2001	P42858
RLNFLVVVLCIVMDR	CASD1	496	Q96PB1
AQMVRVLRRTASRCA	CPZ	191	Q66K79
REQVMDTLVRILARC	DNASE1L1	36	P49184
SFVCQIVRVGRMELR	DOCK1	296	Q14185
CVLILERRRVMAAQV	DMRTC2	71	Q8IXT2
RSCMRQLEKFVRSVH	DHCR24	451	Q15392
CIMFVLCTRAVRTRL	GPR157	276	Q5UAW9
RRRCIALVVEMVLTF	CRYM-AS1	21	A6NIL9
QCLGRRIAELEMTIF	CYP11A1	461	P05108
FITCREAMEARLLLQ	DEF8	381	Q6ZN54
RLVTRFVNEAVMCLQ	HADHA	676	P40939
TIDMRFRIHCQEARI	CCDC168	5501	Q8NDH2
HFLDQCARRVAMLRI	FHOD1	931	Q9Y613
VRIMQFCHTLREFAL	FHOD1	971	Q9Y613
MIAVSFKCRCQILRR	GRIP1	1	Q9Y3R0
RQDLERVRNLCYMIS	JADE3	476	Q92613
LQRVRFCRMDVAVLS	NLRP6	646	P59044
PCLRQMFRSRSIEVF	C9	56	P02748
YNCVKALRSRRINMV	PTPRK	1111	Q15262
VRLCERRLTQLSVME	FBXL21P	386	Q9UKT6
RITRICLRDLIFCME	TAF4B	831	Q92750
IMRLVAECSRSRARA	QTRT1	16	Q9BXR0
SRTAMEFQRRCNTLI	SMARCA1	1006	P28370
MLVRCVTLSLDRFEN	TRPC4AP	626	Q8TEL6
RRVFNDCRDIIQRMH	GNAS	1016	Q5JWF2
DVCSVDRRSVLQRIM	GNL3L	516	Q9NVN8
VFRLSCEQVLHIMRR	SMG1	2391	Q96Q15
CDMARISELRLILRQ	NICN1	106	Q9BSH3
MCIARSLQEFATVLR	ARHGAP26	81	Q9UNA1
LRQEVVVCMRRDTAL	SMARCA4	416	P51532
LIRARACQRVVVMVG	SIRT3	131	Q9NTG7
RTQAICRGFLMRVEF	MYH4	791	Q9Y623
VVRCIQRLAEMCRSL	SKIV2L	1196	Q15477
QRAAGLRRRLVCFTM	SARDH	816	Q9UL12
IRRCSTFQRMIAEVQ	STC1	111	P52823
TQRDLERMENIRFCR	APEH	51	P13798
LPDSVLRRFVVRTMC	AUP1	56	Q9Y679
LRRFVVRTMCAVLGL	AUP1	61	Q9Y679
MIARCLLAVRSLRRV	NLN	1	Q9BYT8
QQLREGSFRVTRMRC	SNX17	306	Q15036
VCVLNREVERVAMTA	TRAF2	286	Q12933
VFRRSFLMTCISLRN	GGCX	691	P38435
VINICERVVRTHSRM	THAP9	771	Q9H5L6
RILRNVSECFLAREM	PROM2	721	Q8N271
LEMRFSRAVRLCGTL	SLC5A5	121	Q92911
VPRSVRTFAQAMRLC	SPIRE2	161	Q8WWL2
CLLTAFSERMRRVPV	SPATA20	671	Q8TB22
EVECPRFLRMLTSRN	SCTR	86	P47872
CAVRAMLYSRAVRNL	SUGP2	656	Q8IX01
MLRRVTVAAVCATRR	NRDC	1	O43847
CQLIVMARNREEREF	SEC63	341	Q9UGP8
LRRDMVFCQTLVATV	PREX2	1261	Q70Z35
RFVRCRNATAEVRMR	TMEM8B	166	A6NDV4
CVTRFVRTLLLIMEH	USP34	2416	Q70CQ2
EVRMRLLQFVTGTCR	WWP1	841	Q9H0M0
RQLISAHVLRRVAMC	UBR4	1886	Q5T4S7
LYRDVMRETIRNLNC	ZNF44	76	P15621
RIRVTFERVEQMCIQ	TRPM7	1196	Q96QT4
RLTILRCVFMRLATI	TMC7	441	Q7Z402
RCVFMRLATICVLVF	TMC7	446	Q7Z402