Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hyaluronan synthase activity	HYAL1 HAS2 HAS3	3.65e-07	4	91	3	GO:0050501
GeneOntologyMolecularFunction	actin binding	EPS8L2 SPATA31A1 SPATA31A3 MYO1C MYO7B MYO9B MICAL2 SPATA31A7 DMD ACE SPATA31A5	1.13e-05	479	91	11	GO:0003779
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	DUOX1 MICAL2 DUOX2	1.96e-05	12	91	3	GO:0016174
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX1 DUOX2	2.05e-05	2	91	2	GO:0106293
GeneOntologyMolecularFunction	cytoskeletal protein binding	EPS8L2 SPATA31A1 SPATA31A3 MYO1C KIF1A MYO7B PACSIN1 MYO9B MICAL2 SPATA31A7 PACSIN3 DMD APOE ACE CCDC88B SPATA31A5	3.34e-05	1099	91	16	GO:0008092
GeneOntologyMolecularFunction	hexosyltransferase activity	HYAL1 FUT9 UGT2B4 GBE1 HAS2 HAS3 GALNT16	5.09e-05	211	91	7	GO:0016758
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	DUOX1 MICAL2 DUOX2	9.87e-05	20	91	3	GO:0050664
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK5 GRK6	1.23e-04	4	91	2	GO:0047696
GeneOntologyMolecularFunction	phospholipid binding	PLEK2 MYO1C PACSIN1 SH3PXD2A GRK5 PACSIN3 APOE MYCBPAP RUBCN ALOX15	1.96e-04	548	91	10	GO:0005543
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX1 DUOX2	2.04e-04	5	91	2	GO:0106294
GeneOntologyMolecularFunction	glycosyltransferase activity	HYAL1 FUT9 UGT2B4 GBE1 HAS2 HAS3 GALNT16	3.48e-04	288	91	7	GO:0016757
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK5 GRK6	4.25e-04	7	91	2	GO:0004703
GeneOntologyMolecularFunction	ATP-dependent activity	SMARCA5 MYO1C KIF1A MYO7B MYO9B ENTPD2 CHD9 YTHDC2 ATP11A CHD6	4.82e-04	614	91	10	GO:0140657
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA5 CHD9 CHD6	6.36e-04	37	91	3	GO:0140658
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	HYAL1 UGT2B4 HAS2 HAS3 GALNT16	6.77e-04	153	91	5	GO:0008194
GeneOntologyMolecularFunction	microfilament motor activity	MYO1C MYO7B MYO9B	6.88e-04	38	91	3	GO:0000146
GeneOntologyMolecularFunction	ATP hydrolysis activity	SMARCA5 KIF1A MYO9B ENTPD2 CHD9 YTHDC2 ATP11A CHD6	9.11e-04	441	91	8	GO:0016887
GeneOntologyMolecularFunction	tetrapyrrole binding	MPO DUOX1 DUOX2 SLC48A1 LMBRD1	9.26e-04	164	91	5	GO:0046906
GeneOntologyMolecularFunction	antioxidant activity	MPO DUOX1 DUOX2 APOE	1.01e-03	97	91	4	GO:0016209
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	MAN2A1 HYAL1 GBE1 SI	1.27e-03	103	91	4	GO:0004553
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	DUOX1 DUOX2	1.32e-03	12	91	2	GO:0016175
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO1C KIF1A MYO7B MYO9B	2.09e-03	118	91	4	GO:0003774
GeneOntologyBiologicalProcess	hyaluronan biosynthetic process	TGFB1 HYAL1 HAS2 HAS3	6.20e-07	16	91	4	GO:0030213
GeneOntologyBiologicalProcess	regulation of peptidyl-cysteine S-nitrosylation	DMD ACE TBC1D24	1.34e-05	11	91	3	GO:2000169
GeneOntologyBiologicalProcess	endocytosis	TGFB1 DRD4 MYO1C MYO7B PACSIN1 PACSIN3 APOE SLC48A1 MYCBPAP LRP1B LMBRD1 RUBCN ALOX15 TBC1D24	1.51e-05	827	91	14	GO:0006897
GeneOntologyBiologicalProcess	polysaccharide biosynthetic process	TGFB1 FUT9 GBE1 HAS2 HAS3	2.16e-05	76	91	5	GO:0000271
GeneOntologyBiologicalProcess	hyaluronan metabolic process	TGFB1 HYAL1 HAS2 HAS3	2.87e-05	40	91	4	GO:0030212
GeneOntologyBiologicalProcess	superoxide metabolic process	TGFB1 MPO DUOX1 SH3PXD2A DUOX2	3.31e-05	83	91	5	GO:0006801
GeneOntologyBiologicalProcess	peptidyl-cysteine S-nitrosylation	DMD ACE TBC1D24	5.40e-05	17	91	3	GO:0018119
GeneOntologyBiologicalProcess	hyaluranon cable assembly	HYAL1 HAS3	5.76e-05	3	91	2	GO:0036118
GeneOntologyBiologicalProcess	cuticle development	DUOX1 DUOX2	5.76e-05	3	91	2	GO:0042335
GeneOntologyBiologicalProcess	regulation of hyaluranon cable assembly	HYAL1 HAS3	5.76e-05	3	91	2	GO:1900104
GeneOntologyBiologicalProcess	positive regulation of hyaluranon cable assembly	HYAL1 HAS3	5.76e-05	3	91	2	GO:1900106
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	TGFB1 GHSR HAVCR2 DRD4 SPATA31A1 SPATA31A3 SPATA31A7 ASPM YTHDC2 BRINP1 IQCN DMD HAS2 ACE MYCBPAP SPATA31A5	6.13e-05	1194	91	16	GO:0048609
GeneOntologyBiologicalProcess	protein nitrosylation	DMD ACE TBC1D24	6.46e-05	18	91	3	GO:0017014
GeneOntologyBiologicalProcess	import into cell	TGFB1 DRD4 SLC9A5 MYO1C MYO7B PACSIN1 PACSIN3 APOE SLC48A1 MYCBPAP LRP1B LMBRD1 RUBCN ALOX15 TBC1D24	6.75e-05	1074	91	15	GO:0098657
GeneOntologyBiologicalProcess	peptidyl-cysteine modification	ZDHHC20 DMD ACE TBC1D24	6.99e-05	50	91	4	GO:0018198
GeneOntologyBiologicalProcess	superoxide anion generation	TGFB1 DUOX1 SH3PXD2A DUOX2	6.99e-05	50	91	4	GO:0042554
GeneOntologyBiologicalProcess	positive regulation by host of viral process	ZDHHC20 YTHDC2 APOE	1.38e-04	23	91	3	GO:0044794
GeneOntologyBiologicalProcess	positive regulation of epithelial cell proliferation	TGFB1 GHSR THBS4 NOG HYAL1 PIK3CD HAS2	1.93e-04	270	91	7	GO:0050679
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	TGFB1 PLEK2 GHSR TBC1D15 EPS8L2 MYO1C HYAL1 APOE HAS2 HAS3 ACE TBC1D17 ALOX15 NCK2 TBC1D24	2.08e-04	1189	91	15	GO:0044087
GeneOntologyBiologicalProcess	regulation of locomotion	TGFB1 GHSR DUOX1 THBS4 DRD4 NOG MYO1C HYAL1 SULF1 PIK3CD FUT9 DUOX2 APOE HAS2 ACE TBC1D24	2.09e-04	1327	91	16	GO:0040012
GeneOntologyBiologicalProcess	polysaccharide metabolic process	TGFB1 FUT9 GBE1 HAS2 HAS3	2.40e-04	126	91	5	GO:0005976
GeneOntologyBiologicalProcess	regulation of morphogenesis of an epithelium	TGFB1 NOG SULF1 PIK3CD	3.57e-04	76	91	4	GO:1905330
GeneOntologyBiologicalProcess	glycosaminoglycan biosynthetic process	TGFB1 HYAL1 HAS2 HAS3	3.57e-04	76	91	4	GO:0006024
GeneOntologyBiologicalProcess	hydrogen peroxide catabolic process	MPO DUOX1 DUOX2	4.12e-04	33	91	3	GO:0042744
GeneOntologyBiologicalProcess	reactive oxygen species biosynthetic process	MPO DUOX1 DUOX2 DMD	4.34e-04	80	91	4	GO:1903409
GeneOntologyBiologicalProcess	aminoglycan biosynthetic process	TGFB1 HYAL1 HAS2 HAS3	4.34e-04	80	91	4	GO:0006023
GeneOntologyBiologicalProcess	regulation of epithelial cell proliferation	TGFB1 GHSR THBS4 NOG HYAL1 SULF1 PIK3CD APOE HAS2	4.43e-04	514	91	9	GO:0050678
GeneOntologyBiologicalProcess	regulation of cell motility	TGFB1 DUOX1 THBS4 DRD4 NOG MYO1C HYAL1 SULF1 PIK3CD FUT9 DUOX2 APOE HAS2 ACE TBC1D24	4.57e-04	1280	91	15	GO:2000145
GeneOntologyCellularComponent	cell leading edge	PLEK2 KSR1 DUOX1 EPS8L2 SLC9A5 MYO1C PACSIN1 MYO9B DUOX2 DMD TMEM87A	1.23e-05	500	92	11	GO:0031252
GeneOntologyCellularComponent	hyaluranon cable	HYAL1 HAS3	1.92e-05	2	92	2	GO:0036117
GeneOntologyCellularComponent	cell projection membrane	PLEK2 KSR1 EPS8L2 SLC9A5 MYO1C PACSIN1 ENTPD2 DMD ACE	1.19e-04	431	92	9	GO:0031253
GeneOntologyCellularComponent	actin-based cell projection	TGFB1 EPS8L2 MYO1C MYO7B MYO9B DEF6 DMD	2.28e-04	278	92	7	GO:0098858
GeneOntologyCellularComponent	ruffle	KSR1 EPS8L2 MYO1C PACSIN1 MYO9B TMEM87A	3.00e-04	206	92	6	GO:0001726
GeneOntologyCellularComponent	leading edge membrane	PLEK2 KSR1 EPS8L2 SLC9A5 MYO1C PACSIN1	3.33e-04	210	92	6	GO:0031256
GeneOntologyCellularComponent	B-WICH complex	SMARCA5 MYO1C	5.27e-04	8	92	2	GO:0110016
GeneOntologyCellularComponent	Golgi apparatus subcompartment	MMP24 MAN2A1 WDR11 PACSIN1 SULF1 FUT9 PACSIN3 TMEM87A	7.52e-04	443	92	8	GO:0098791
GeneOntologyCellularComponent	ruffle membrane	KSR1 EPS8L2 MYO1C PACSIN1	1.33e-03	108	92	4	GO:0032587
MousePheno	abnormal adenohypophysis morphology	NOG WDR11 SH3PXD2A DUOX2 ATP11A DMD	8.91e-06	92	74	6	MP:0004163
MousePheno	diaphragmitis	TGFB1 DMD	2.76e-05	2	74	2	MP:0013467
MousePheno	abnormal atrium myocardium morphology	SH3PXD2A ATP11A DMD	6.19e-05	15	74	3	MP:0010493
MousePheno	abnormal pituitary gland morphology	NOG WDR11 SH3PXD2A DUOX2 ATP11A DMD	7.85e-05	135	74	6	MP:0000633
Domain	IQ	SPATA17 MYO1C MYO7B MYO9B ASPM IQCN	1.34e-06	71	92	6	PF00612
Domain	IQ	SPATA17 MYO1C MYO7B MYO9B ASPM IQCN	2.92e-06	81	92	6	SM00015
Domain	IQ_motif_EF-hand-BS	SPATA17 MYO1C MYO7B MYO9B ASPM IQCN	5.41e-06	90	92	6	IPR000048
Domain	IQ	SPATA17 MYO1C MYO7B MYO9B ASPM IQCN	6.54e-06	93	92	6	PS50096
Domain	Haem_peroxidase	MPO DUOX1 DUOX2	1.35e-05	10	92	3	IPR010255
Domain	An_peroxidase	MPO DUOX1 DUOX2	1.35e-05	10	92	3	PF03098
Domain	PEROXIDASE_3	MPO DUOX1 DUOX2	1.35e-05	10	92	3	PS50292
Domain	Haem_peroxidase_animal	MPO DUOX1 DUOX2	1.35e-05	10	92	3	IPR019791
Domain	-	MPO DUOX1 DUOX2	1.35e-05	10	92	3	1.10.640.10
Domain	DUOX1	DUOX1 DUOX2	2.40e-05	2	92	2	IPR029595
Domain	DUF3548	TBC1D15 TBC1D17	2.40e-05	2	92	2	PF12068
Domain	DUF3548	TBC1D15 TBC1D17	2.40e-05	2	92	2	IPR021935
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	2.46e-05	12	92	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	2.46e-05	12	92	3	IPR027970
Domain	BRINP	BRINP2 BRINP1	7.18e-05	3	92	2	IPR033237
Domain	HAS/NodC	HAS2 HAS3	7.18e-05	3	92	2	IPR026107
Domain	BRK	CHD9 CHD6	3.55e-04	6	92	2	SM00592
Domain	BRK_domain	CHD9 CHD6	3.55e-04	6	92	2	IPR006576
Domain	BRK	CHD9 CHD6	3.55e-04	6	92	2	PF07533
Domain	Glycos_transf_2	HAS2 HAS3 GALNT16	4.26e-04	30	92	3	PF00535
Domain	Glyco_trans_2-like	HAS2 HAS3 GALNT16	4.26e-04	30	92	3	IPR001173
Domain	GPCR_kinase	GRK5 GRK6	4.96e-04	7	92	2	IPR000239
Domain	NAD_binding_6	DUOX1 DUOX2	4.96e-04	7	92	2	PF08030
Domain	FAD_binding_8	DUOX1 DUOX2	4.96e-04	7	92	2	PF08022
Domain	FAD-bd_8	DUOX1 DUOX2	4.96e-04	7	92	2	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX1 DUOX2	4.96e-04	7	92	2	IPR013121
Domain	SNF2_N	SMARCA5 CHD9 CHD6	5.17e-04	32	92	3	IPR000330
Domain	SNF2_N	SMARCA5 CHD9 CHD6	5.17e-04	32	92	3	PF00176
Domain	SH3	EPS8L2 MYO7B PACSIN1 SH3PXD2A PACSIN3 NCK2	6.96e-04	216	92	6	SM00326
Domain	SH3	EPS8L2 MYO7B PACSIN1 SH3PXD2A PACSIN3 NCK2	6.96e-04	216	92	6	PS50002
Domain	SH3_domain	EPS8L2 MYO7B PACSIN1 SH3PXD2A PACSIN3 NCK2	7.66e-04	220	92	6	IPR001452
Domain	DEAH_ATP_HELICASE	SMARCA5 YTHDC2 CHD6	8.61e-04	38	92	3	PS00690
Domain	Myosin_head_motor_dom	MYO1C MYO7B MYO9B	8.61e-04	38	92	3	IPR001609
Domain	MYOSIN_MOTOR	MYO1C MYO7B MYO9B	8.61e-04	38	92	3	PS51456
Domain	Myosin_head	MYO1C MYO7B MYO9B	8.61e-04	38	92	3	PF00063
Domain	MYSc	MYO1C MYO7B MYO9B	8.61e-04	38	92	3	SM00242
Domain	MAC_perforin	BRINP2 BRINP1	1.05e-03	10	92	2	IPR001862
Domain	MACPF	BRINP2 BRINP1	1.28e-03	11	92	2	PF01823
Domain	SH3_1	EPS8L2 PACSIN1 SH3PXD2A PACSIN3 NCK2	1.31e-03	164	92	5	PF00018
Domain	MACPF	BRINP2 BRINP1	1.53e-03	12	92	2	SM00457
Domain	Ferric_reduct	DUOX1 DUOX2	1.53e-03	12	92	2	PF01794
Domain	MACPF	BRINP2 BRINP1	1.53e-03	12	92	2	IPR020864
Domain	Fe3_Rdtase_TM_dom	DUOX1 DUOX2	1.53e-03	12	92	2	IPR013130
Domain	TBC	TBC1D15 TBC1D17 TBC1D24	1.81e-03	49	92	3	SM00164
Domain	Helicase_C	SMARCA5 CHD9 YTHDC2 CHD6	1.93e-03	107	92	4	PF00271
Domain	HELICc	SMARCA5 CHD9 YTHDC2 CHD6	1.93e-03	107	92	4	SM00490
Domain	Helicase_C	SMARCA5 CHD9 YTHDC2 CHD6	2.00e-03	108	92	4	IPR001650
Domain	HELICASE_CTER	SMARCA5 CHD9 YTHDC2 CHD6	2.07e-03	109	92	4	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA5 CHD9 YTHDC2 CHD6	2.07e-03	109	92	4	PS51192
Domain	DEXDc	SMARCA5 CHD9 YTHDC2 CHD6	2.07e-03	109	92	4	SM00487
Domain	-	MAN2A1 GBE1	2.10e-03	14	92	2	2.60.40.1180
Domain	Helicase_ATP-bd	SMARCA5 CHD9 YTHDC2 CHD6	2.14e-03	110	92	4	IPR014001
Domain	RabGAP-TBC	TBC1D15 TBC1D17 TBC1D24	2.27e-03	53	92	3	PF00566
Domain	Glycoside_hydrolase_SF	HYAL1 GBE1 SI	2.27e-03	53	92	3	IPR017853
Domain	Glyco_hydro_b	MAN2A1 GBE1	2.42e-03	15	92	2	IPR013780
Domain	TBC_RABGAP	TBC1D15 TBC1D17 TBC1D24	2.52e-03	55	92	3	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D15 TBC1D17 TBC1D24	2.52e-03	55	92	3	IPR000195
Domain	P-loop_NTPase	SMARCA5 SPATA17 MYO1C KIF1A MYO7B MYO9B ASPM CHD9 YTHDC2 CHD6 IQCN	2.97e-03	848	92	11	IPR027417
Domain	Gal_mutarotase_SF_dom	MAN2A1 SI	3.11e-03	17	92	2	IPR011013
Domain	Fd_Rdtase_FAD-bd	DUOX1 DUOX2	3.89e-03	19	92	2	IPR017927
Domain	FAD_FR	DUOX1 DUOX2	3.89e-03	19	92	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 DUOX2	3.89e-03	19	92	2	IPR017938
Domain	CH	MICAL2 ASPM DMD	4.05e-03	65	92	3	SM00033
Domain	CH	MICAL2 ASPM DMD	4.99e-03	70	92	3	PF00307
Domain	-	MICAL2 ASPM DMD	5.19e-03	71	92	3	1.10.418.10
Pathway	REACTOME_HYALURONAN_METABOLISM	HYAL1 HAS2 HAS3	8.25e-05	17	72	3	M666
Pathway	REACTOME_HYALURONAN_METABOLISM	HYAL1 HAS2 HAS3	8.25e-05	17	72	3	MM14864
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	7.16e-10	6	93	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	7.16e-10	6	93	4	25930072
Pubmed	Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening.	TGFB1 HAS2 HAS3	7.39e-08	4	93	3	18587729
Pubmed	Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta.	TGFB1 HAS2 HAS3	7.39e-08	4	93	3	14636845
Pubmed	Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-beta upregulates their expression in cultured human skin cells.	TGFB1 HAS2 HAS3	7.39e-08	4	93	3	9457904
Pubmed	Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content.	HYAL1 HAS2 HAS3	1.84e-07	5	93	3	19435493
Pubmed	Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.	HYAL1 HAS2 HAS3	1.84e-07	5	93	3	20875124
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A5	4.89e-07	24	93	4	32212159
Pubmed	Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.	TGFB1 HYAL1 HAS2	1.03e-06	8	93	3	17324121
Pubmed	An introduction of genetics in otosclerosis: a systematic review.	TGFB1 NOG ACE	1.54e-06	9	93	3	24170657
Pubmed	A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).	TGFB1 MPO THBS4 APOE ACE	2.52e-06	80	93	5	19420105
Pubmed	Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.	TGFB1 NOG HYAL1 SULF1 HAS2	4.50e-06	90	93	5	30228991
Pubmed	Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.	TGFB1 DUOX1 DUOX2 APOE ACE	5.58e-06	94	93	5	20346360
Pubmed	Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.	DUOX1 DUOX2	7.07e-06	2	93	2	28633507
Pubmed	Lack of association between angiotensin converting enzyme polymorphism and sporadic Alzheimer's disease.	APOE ACE	7.07e-06	2	93	2	12459519
Pubmed	Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.	TBC1D15 TBC1D17	7.07e-06	2	93	2	24569479
Pubmed	Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells.	HYAL1 HAS3	7.07e-06	2	93	2	16900089
Pubmed	N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization.	YTHDC2 FTO	7.07e-06	2	93	2	33713148
Pubmed	Combined "pro-atherosclerotic" variants of the ACE and APOE genes increase the risk of the coronary artery disease associated with the presence of cigarette smoking.	APOE ACE	7.07e-06	2	93	2	19157170
Pubmed	The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease.	APOE ACE	7.07e-06	2	93	2	17401152
Pubmed	Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.	GRK5 APOE	7.07e-06	2	93	2	17018529
Pubmed	Does the level of LDL cholesterol moderate a relationship between DRD4 and novelty seeking?	DRD4 APOE	7.07e-06	2	93	2	15312696
Pubmed	Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.	DUOX1 DUOX2	7.07e-06	2	93	2	22523549
Pubmed	Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis.	DUOX1 DUOX2	7.07e-06	2	93	2	23281318
Pubmed	Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice.	APOE ALOX15	7.07e-06	2	93	2	11342477
Pubmed	Hyaluronan synthases and hyaluronidases in nasal polyps.	HYAL1 HAS2	7.07e-06	2	93	2	26661071
Pubmed	Association studies of transforming growth factor-beta 1 and Alzheimer's disease.	TGFB1 APOE	7.07e-06	2	93	2	16082716
Pubmed	Thrombospondin-4 critically controls transforming growth factor β1 induced hypertrophic scar formation.	TGFB1 THBS4	7.07e-06	2	93	2	30132849
Pubmed	Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe.	APOE ACE	7.07e-06	2	93	2	12954489
Pubmed	Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease.	APOE ACE	7.07e-06	2	93	2	16033878
Pubmed	Synergistic effects of ACE (I/D) and ApoE (HhaI) gene polymorphisms among the adult Asian Indians with and without metabolic syndrome.	APOE ACE	7.07e-06	2	93	2	19800705
Pubmed	Association of APOE (Hha1) and ACE (I/D) gene polymorphisms with type 2 diabetes mellitus in North West India.	APOE ACE	7.07e-06	2	93	2	16621107
Pubmed	Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein e genes and human longevity in Colombia.	APOE ACE	7.07e-06	2	93	2	16971231
Pubmed	Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.	DUOX1 DUOX2	7.07e-06	2	93	2	23362256
Pubmed	The ACE Insertion Deletion polymorphism relates to dementia by metabolic phenotype, APOEepsilon4, and age of dementia onset.	APOE ACE	7.07e-06	2	93	2	18838196
Pubmed	Tissue angiotensin-converting-enzyme (ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis: studies in ACE-knockout mice type 2.	APOE ACE	7.07e-06	2	93	2	14525797
Pubmed	Myeloperoxidase G-463A polymorphism and Alzheimer's disease in the ApoEurope study.	MPO APOE	7.07e-06	2	93	2	12946561
Pubmed	Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system.	DUOX1 DUOX2	7.07e-06	2	93	2	11822874
Pubmed	Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.	DUOX1 DUOX2	7.07e-06	2	93	2	18177232
Pubmed	Overexpression of TGF-ß1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice.	TGFB1 APOE	7.07e-06	2	93	2	22829904
Pubmed	Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.	TGFB1 APOE	7.07e-06	2	93	2	19549280
Pubmed	Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.	DUOX1 DUOX2	7.07e-06	2	93	2	12824283
Pubmed	The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.	HAS2 HAS3	7.07e-06	2	93	2	20507985
Pubmed	Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGFβ1 signaling in the mdx mouse model of Duchenne muscular dystrophy.	TGFB1 DMD	7.07e-06	2	93	2	23911435
Pubmed	Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease.	APOE ACE	7.07e-06	2	93	2	11501342
Pubmed	Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.	DUOX1 DUOX2	7.07e-06	2	93	2	24161126
Pubmed	Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine.	MPO APOE	7.07e-06	2	93	2	28971841
Pubmed	Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis.	MPO APOE	7.07e-06	2	93	2	15222689
Pubmed	APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study.	APOE ACE	7.07e-06	2	93	2	19939808
Pubmed	Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians.	APOE ACE	7.07e-06	2	93	2	12634288
Pubmed	Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies.	HYAL1 DMD	7.07e-06	2	93	2	23007393
Pubmed	Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-β1 in a mouse model of osteoarthritis.	TGFB1 NOG	7.07e-06	2	93	2	34298323
Pubmed	Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy.	TGFB1 APOE	7.07e-06	2	93	2	15834029
Pubmed	Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.	APOE ALOX15	7.07e-06	2	93	2	26956187
Pubmed	Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.	APOE ALOX15	7.07e-06	2	93	2	10359569
Pubmed	Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.	DUOX1 DUOX2	7.07e-06	2	93	2	16111680
Pubmed	TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.	TGFB1 APOE	7.07e-06	2	93	2	19325140
Pubmed	Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.	DUOX1 DUOX2	7.07e-06	2	93	2	11753072
Pubmed	Regulated hydrogen peroxide production by Duox in human airway epithelial cells.	DUOX1 DUOX2	7.07e-06	2	93	2	15677770
Pubmed	Enhanced sensitivity to low dose irradiation of ApoE-/- mice mediated by early pro-inflammatory profile and delayed activation of the TGFβ1 cascade involved in fibrogenesis.	TGFB1 APOE	7.07e-06	2	93	2	23451141
Pubmed	Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.	DUOX1 DUOX2	7.07e-06	2	93	2	24128054
Pubmed	Association of apolipoprotein E and angiotensin converting enzyme gene polymorphisms with the multidimensional impairment in older patients.	APOE ACE	7.07e-06	2	93	2	19653879
Pubmed	Overexpression of myeloid angiotensin-converting enzyme (ACE) reduces atherosclerosis.	APOE ACE	7.07e-06	2	93	2	31615657
Pubmed	[Apolipoprotein E and angiotensin-converting enzyme gene polymorphisms as risk factors of coronary disease].	APOE ACE	7.07e-06	2	93	2	15217762
Pubmed	Association between the LRP1B and APOE loci and the development of Parkinson's disease dementia.	APOE LRP1B	7.07e-06	2	93	2	36348503
Pubmed	Lack of association between TGF-beta-1 genotypes and microalbuminuria in essential hypertensive men.	TGFB1 ACE	7.07e-06	2	93	2	19176688
Pubmed	[The role of angiotensin-converting enzyme and apolipoprotein E in the development of intracranial aneurysms.].	APOE ACE	7.07e-06	2	93	2	18477980
Pubmed	Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy.	APOE ACE	7.07e-06	2	93	2	16960022
Pubmed	Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.	DUOX1 DUOX2	7.07e-06	2	93	2	31706280
Pubmed	Factor analysis of risk variables associated with metabolic syndrome in adult Asian Indians.	APOE ACE	7.07e-06	2	93	2	20877692
Pubmed	A study of French centenarians: are ACE and APOE associated with longevity?	APOE ACE	7.07e-06	2	93	2	11280044
Pubmed	Interaction of angiotensin-converting enzyme and apolipoprotein E gene polymorphisms in ischemic stroke involving large-vessel disease.	APOE ACE	7.07e-06	2	93	2	18027070
Pubmed	Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression.	APOE HAS3	7.07e-06	2	93	2	28987865
Pubmed	Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity.	DUOX1 DUOX2	7.07e-06	2	93	2	15972824
Pubmed	Variation in the DCP1 gene, encoding the angiotensin converting enzyme ACE, is not associated with increased susceptibility to Alzheimer's disease.	APOE ACE	7.07e-06	2	93	2	12605101
Pubmed	Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.	DUOX1 DUOX2	7.07e-06	2	93	2	19144650
Pubmed	Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.	DUOX1 DUOX2	7.07e-06	2	93	2	11762710
Pubmed	Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.	GRK5 GRK6	7.07e-06	2	93	2	17786238
Pubmed	[Polymorphism of the gene of angiotensin-converting enzyme and apolipoprotein E gene in long-livers of Novosibirsk city].	APOE ACE	7.07e-06	2	93	2	14743603
Pubmed	Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.	DUOX1 DUOX2	7.07e-06	2	93	2	30375286
Pubmed	Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.	DUOX1 DUOX2	7.07e-06	2	93	2	10806195
Pubmed	Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.	DUOX1 DUOX2	7.07e-06	2	93	2	11514595
Pubmed	Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy.	THBS4 DMD	7.07e-06	2	93	2	29712757
Pubmed	Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.	TGFB1 HAVCR2	7.07e-06	2	93	2	25608525
Pubmed	Expression of reduced nicotinamide adenine dinucleotide phosphate oxidase (ThoX, LNOX, Duox) genes and proteins in human thyroid tissues.	DUOX1 DUOX2	7.07e-06	2	93	2	11443211
Pubmed	Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.	GRK5 GRK6	7.07e-06	2	93	2	20038610
Pubmed	Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas.	DUOX1 DUOX2	7.07e-06	2	93	2	10601291
Pubmed	Relation of Apo E and ACE genes to cognitive performance in chronic alcoholic patients.	APOE ACE	7.07e-06	2	93	2	12006218
Pubmed	Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice.	HYAL1 APOE	7.07e-06	2	93	2	21170388
Pubmed	A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease.	APOE ACE	7.07e-06	2	93	2	14698449
Pubmed	The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release.	DUOX1 DUOX2	7.07e-06	2	93	2	25586178
Pubmed	Versatile membrane deformation potential of activated pacsin.	PACSIN1 PACSIN3	7.07e-06	2	93	2	23236520
Pubmed	Thrombospondin-4 mediates TGF-β-induced angiogenesis.	TGFB1 THBS4	7.07e-06	2	93	2	28481870
Pubmed	12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway.	APOE ALOX15	7.07e-06	2	93	2	16303615
Pubmed	Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.	DUOX1 DUOX2	7.07e-06	2	93	2	18281478
Pubmed	Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions.	DUOX1 DUOX2	7.07e-06	2	93	2	15062544
Pubmed	PTP-Pez: a novel regulator of TGFbeta signaling.	TGFB1 PTPN14	7.07e-06	2	93	2	18677119
Pubmed	The effect of the APOE-epsilon4 allele and ACE-I/D polymorphism on cognition during a two-year follow-up in first-ever stroke patients.	APOE ACE	7.07e-06	2	93	2	20606435
Pubmed	The P387 thrombospondin-4 variant promotes accumulation of macrophages in atherosclerotic lesions.	THBS4 APOE	7.07e-06	2	93	2	32686880
Pubmed	Impact of ACE and ApoE polymorphisms on myocardial perfusion: correlation with myocardial single photon emission computed tomographic imaging.	APOE ACE	7.07e-06	2	93	2	19713976
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	1.13e-04	8	93	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	1.09e-03	24	93	2	9p13.1
Cytoband	15q15.3	DUOX1 DUOX2	1.18e-03	25	93	2	15q15.3
Cytoband	16q12.2	CHD9 FTO	1.28e-03	26	93	2	16q12.2
Cytoband	5q33.3	HAVCR2 RNF145	2.45e-03	36	93	2	5q33.3
GeneFamily	Glycosyltransferase family 2	HAS2 HAS3	1.30e-04	6	54	2	428
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 MICAL2 SLC4A4 ACE FAM217A	1.12e-07	182	93	7	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 MICAL2 SLC4A4 ACE FAM217A	1.12e-07	182	93	7	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	MICAL2 ATP11A BRINP1 HAS3 SLC4A4 RNF145 TBC1D24	1.91e-07	197	93	7	5e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENTPD2 ASPM FUT9 BRINP2 SLC4A4 TBC1D17	1.13e-06	161	93	6	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 SLC9A5 PACSIN3 DUOX2 HAS3 FAM217A	1.83e-06	175	93	6	9d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 SLC9A5 PACSIN3 DUOX2 HAS3 FAM217A	1.83e-06	175	93	6	f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 PTPN14 SULF1 MICAL2 DMD	2.37e-06	183	93	6	351d575339038bd4a66f408da518c567444208e8
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	EPS8L2 SPATA17 FUT9 ATP11A KLHDC7A HAS3	2.45e-06	184	93	6	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	droplet-Lung-nan-21m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEK2 EPS8L2 SULF1 MICAL2 ACE FAM217A	2.60e-06	186	93	6	5d0cd07b6b51e8ce9e1da949f757dc4575ec5752
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 PTPN14 SULF1 MICAL2 ACE	2.69e-06	187	93	6	7170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAMR1 SULF1 ENTPD2 HAS2 ACE GALNT16	2.77e-06	188	93	6	aa516273cdde53c8c0295f06830972388f890c97
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 PTPN14 SULF1 MICAL2 DMD	2.94e-06	190	93	6	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 MICAL2 ATP11A SLC4A4 RNF145 TMEM87A	3.73e-06	198	93	6	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 MICAL2 ATP11A SLC4A4 RNF145 TMEM87A	3.84e-06	199	93	6	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEK2 ZDHHC20 MMP24 ASPM FUT9	6.53e-06	125	93	5	35042ed43045dddc341b76cc5f9fe31b5ba0abb8
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEK2 ZDHHC20 MMP24 ASPM FUT9	6.79e-06	126	93	5	4eeea015efe17e0aae5bd76b71fa70b5149dfada
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO KIF1A ASPM APOE LRP1B	1.06e-05	138	93	5	c1a46fbf1beffa12c3d1b78361e0613e2e9e2d13
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO HAVCR2 PCYOX1L ACE CCDC88B	2.09e-05	159	93	5	cdbccb83af6220bab300dfe56443ff69f6e2043a
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAVCR2 MYO9B APOE ACE LMBRD1	2.43e-05	164	93	5	b77995958c938e10a526118f75d78cee72e0b207
ToppCell	wk_20-22-Epithelial-Airway_epithelial_progenitor\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PLEK2 SMARCA5 EPS8L2 ATP11A HAS3	2.57e-05	166	93	5	fcd0bd70b553789092249806ace324b77bd10481
ToppCell	wk_20-22-Epithelial-Airway_epithelial_progenitor-epi-stalk_late\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PLEK2 SMARCA5 EPS8L2 ATP11A HAS3	2.57e-05	166	93	5	b60954e5625743657d0fd9264b738b46e72fd8a6
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tnaive/CM_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MPO PCYOX1L DRD4 GBE1 MYCBPAP	2.73e-05	168	93	5	c51244b4bdbfd961e2725306aa9cb25dd66d58bd
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUOX1 HAS2 SLC4A4 ACE GALNT16	3.79e-05	180	93	5	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN14 SULF1 ENTPD2 HAS2 SLC4A4	3.79e-05	180	93	5	c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 SLC4A4 FAM217A	3.89e-05	181	93	5	136b0c60680068838d184d32aa99d7bea8718dbc
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEK2 PTPN14 SULF1 MICAL2 SLC4A4	4.10e-05	183	93	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	YEATS2 PCYOX1L GBE1 IQCN CCDC88B	4.10e-05	183	93	5	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 MYO7B DMD SLC4A4 LRP1B	4.21e-05	184	93	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 ACE FAM217A	4.21e-05	184	93	5	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EPS8L2 PTPN14 MICAL2 GRK5 ATP11A	4.21e-05	184	93	5	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 MYO7B DMD SLC4A4 LRP1B	4.21e-05	184	93	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 MYO7B DMD SLC4A4 LRP1B	4.21e-05	184	93	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EPS8L2 PTPN14 MICAL2 GRK5 ATP11A	4.21e-05	184	93	5	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEK2 EPS8L2 PTPN14 SULF1 MICAL2	4.43e-05	186	93	5	1e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 SULF1 MICAL2 SLC4A4 FAM217A	4.43e-05	186	93	5	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 PTPN14 SULF1 MICAL2	4.43e-05	186	93	5	ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 PTPN14 SULF1 MICAL2	4.43e-05	186	93	5	ed924852cd7132c8f6703522037dc22bd2c83193
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 MICAL2 ACE	4.54e-05	187	93	5	12129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 MICAL2 ACE	4.54e-05	187	93	5	83930ef55191eff9006113feaeabb3c2fa21fd05
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEK2 EPS8L2 SULF1 MICAL2 ACE	4.66e-05	188	93	5	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	DUOX1 MICAL2 ATP11A SLC4A4 RNF145	4.66e-05	188	93	5	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	THBS4 PTPN14 PAMR1 SULF1 GRK5	4.78e-05	189	93	5	c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 PTPN14 SULF1 MICAL2	4.90e-05	190	93	5	3b9abc25b17e7295356ded57ff2ca519fa9f2686
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MPO WDR11 ASPM TMEM87A RUBCN	4.90e-05	190	93	5	3f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA5 SULF1 ENTPD2 CHD9 HAS2	5.02e-05	191	93	5	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 MICAL2 ACE	5.02e-05	191	93	5	6e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK2 EPS8L2 SULF1 MICAL2 ACE	5.02e-05	191	93	5	482db995930346be69072ace2fd78fd453e97fb5
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	PAMR1 SULF1 GRK5 CHD9 APOE	5.02e-05	191	93	5	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAMR1 SULF1 ENTPD2 ACE GALNT16	5.15e-05	192	93	5	30cefa0990ba1f379f350bfbf994a78db145075e
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MPO WDR11 ASPM TMEM87A RUBCN	5.15e-05	192	93	5	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAMR1 SULF1 MICAL2 GRK5 DMD	5.28e-05	193	93	5	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAMR1 SULF1 HAS2 ACE GALNT16	5.41e-05	194	93	5	7b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	PAMR1 SULF1 GRK5 CHD9 APOE	5.41e-05	194	93	5	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DUOX1 MICAL2 ATP11A SLC4A4 RNF145	5.41e-05	194	93	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	18-Airway-Epithelial-Bud_tip_adjacent\|Airway / Age, Tissue, Lineage and Cell class	SMARCA5 EPS8L2 ATP11A DMD HAS3	5.41e-05	194	93	5	b45f1e80074a19245bc5dc4b3a583419a1904404
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SMARCA5 EPS8L2 ATP11A DMD HAS3	5.54e-05	195	93	5	0e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell	ASK440-Epithelial-Type_2\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	DUOX1 ATP11A HAS3 RNF145 TMEM87A	5.68e-05	196	93	5	754b4202b617165c6994a0b5a9b1e486dccdd44d
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	THBS4 SULF1 GRK5 ENTPD2 GALNT16	5.68e-05	196	93	5	ee45e4de9d706ec87094e87f47d3e514539b8092
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MMP24 EPS8L2 MYO1C MICAL2 ATP11A	5.68e-05	196	93	5	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAMR1 SULF1 HAS2 ACE GALNT16	5.68e-05	196	93	5	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	THBS4 SULF1 GRK5 ENTPD2 GALNT16	5.68e-05	196	93	5	fa4a85a3cd52df0da5dfedc0e584e9df8c61ce89
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	YEATS2 EPS8L2 PTPN14 MYO1C GRK5	5.82e-05	197	93	5	8d5097898dd01cedb04cb694cb480c931e08462c
ToppCell	medial-Hematologic-Interstitial_Macrophage-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLEK2 HAVCR2 ZDHHC20 GRK6 APOE	5.82e-05	197	93	5	b90c8a41e99c87b46be699d03cd49c97a2ad51af
ToppCell	wk_15-18-Epithelial-Distal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SMARCA5 EPS8L2 ATP11A DMD HAS3	5.82e-05	197	93	5	b7aff83c27606d87565382a768119a863fe1c294
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAMR1 SULF1 MICAL2 GRK5 DMD	5.82e-05	197	93	5	80e153790cef37b743e22a7370ff5b3a6abf147d
ToppCell	ASK440-Epithelial-Type_2\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	DUOX1 ATP11A HAS3 RNF145 TMEM87A	5.82e-05	197	93	5	08d5bbeb77a4152af1c783bc958afcae24667767
ToppCell	medial-Hematologic-Interstitial_Macrophage\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLEK2 HAVCR2 ZDHHC20 GRK6 APOE	5.82e-05	197	93	5	13aec816e21754eac590a12c3a9c795c41108277
ToppCell	medial-2-Hematologic-Interstitial_Macrophage\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLEK2 HAVCR2 ZDHHC20 GRK6 APOE	5.82e-05	197	93	5	38a74eeb2a4c8d6a86b133f02f4e6c641f16a3ac
ToppCell	Biopsy_IPF-Epithelial-AT1\|Biopsy_IPF / Sample group, Lineage and Cell type	MMP24 EPS8L2 HYAL1 GRK5 ATP11A	5.96e-05	198	93	5	75bdecbe111fededf6082b11de18b84ca308ef6d
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_late\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SMARCA5 EPS8L2 ATP11A DMD HAS3	5.96e-05	198	93	5	1851b7f4198b42c21c934e2fbda39dbd65e2625c
ToppCell	distal-Epithelial-Alveolar_Epithelial_Type_2-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DUOX1 MICAL2 ATP11A HAS3 RNF145	5.96e-05	198	93	5	de5748c2b66ecc432974cf095ecd241369579f7c
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SMARCA5 EPS8L2 ATP11A DMD HAS3	5.96e-05	198	93	5	c477405b093f4e5374e57bcacf1fb204a0f7eb3b
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-A_(AT2)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	SMARCA5 SH3PXD2A ATP11A IQCN HAS3	6.10e-05	199	93	5	09cf004032e5af912ee0cdde6e24ce3bcf7673cd
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 MICAL2 ATP11A SLC4A4 TMEM87A	6.10e-05	199	93	5	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 MICAL2 ATP11A SLC4A4 TMEM87A	6.10e-05	199	93	5	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 MICAL2 ATP11A RNF145 TMEM87A	6.10e-05	199	93	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_intermediate\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SMARCA5 EPS8L2 ATP11A DMD HAS3	6.10e-05	199	93	5	debdd7dba774d9ccff7effc3f4c132393d203dfa
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENTPD2 PACSIN3 DMD APOE ALOX15	6.10e-05	199	93	5	a76aa30fb264bdcbc0cb09113f814fc5a89e7319
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF1A ENTPD2 DMD APOE ALOX15	6.10e-05	199	93	5	5f350d9c7da9ac111bf22623dd4fed7f7983c9fc
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANO2 NOG HYAL1 GRK5 ACE	6.10e-05	199	93	5	fff88d2bba262583bb726900ae01e44954b72eb9
ToppCell	wk_20-22-Mesenchymal-Fibroblast-Adventitial_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	KDELR2 PAMR1 SULF1 ENTPD2 GALNT16	6.10e-05	199	93	5	ab0589c068c24aa989bdca083504fbad0c15221d
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ENTPD2 PACSIN3 DMD APOE ALOX15	6.10e-05	199	93	5	a816b0eed80530113b7e720bbd2311a544ed8ed1
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	THBS4 SH3PXD2A ENTPD2 PACSIN3 TBC1D24	6.25e-05	200	93	5	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	THBS4 ENTPD2 KLHDC7A SLC4A4	8.65e-05	111	93	4	7d7aad8e9811c67fb9abfb4ebc75def01a517adf
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	THBS4 ENTPD2 KLHDC7A SLC4A4	8.65e-05	111	93	4	cb45322fbeafec2f1ab7a3727da69abb1047567d
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN14 SULF1 ASPM ACE	1.13e-04	119	93	4	c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell	Entopeduncular-Macroglia-ASTROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	THBS4 PAMR1 ENTPD2 KLHDC7A	1.55e-04	129	93	4	c37bdd6c0b2944fbfa064922954ea0e263160e2a
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	THBS4 PAMR1 ENTPD2 KLHDC7A	1.55e-04	129	93	4	8648ae59f7aca0f5b4983bdb4a65b03b2ca761e1
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC20 MMP24 ASPM FUT9	1.64e-04	131	93	4	419a0a83b38eaea890d065c3f252ef83c2d37b5b
ToppCell	NS-critical-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DRD4 MYO7B PACSIN1 ASPM	2.36e-04	144	93	4	0fde5cd82df9b90aefde19275cff6c2ec3c9d5cb
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ENTPD2 KLHDC7A APOE SLC4A4	3.27e-04	157	93	4	0551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCell	frontal_cortex-Non-neuronal-astrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ENTPD2 KLHDC7A APOE SLC4A4	3.27e-04	157	93	4	803af734d7f775d294391e2b84e472a732e18cef
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ENTPD2 KLHDC7A APOE SLC4A4	3.27e-04	157	93	4	9aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HAVCR2 KIF1A FUT9 CCDC88B	3.60e-04	161	93	4	afc719ffa53ab34c5628da47936da1f731dceab1
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THBS4 PTPN14 DUOX2 FAM217A	3.69e-04	162	93	4	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HAVCR2 KIF1A FUT9 CCDC88B	3.86e-04	164	93	4	90404b3b6b6a9b88a75cba09baa94c718e577c44
ToppCell	368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SULF1 BRINP2 SLC4A4 ALOX15	4.04e-04	166	93	4	4d63c758d46e73311b864148c646bf081498dee7
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPS8L2 PTPN14 SULF1 ACE	4.04e-04	166	93	4	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TGFB1 HAVCR2 CHD9 CCDC88B	4.04e-04	166	93	4	063d68f2ffb40770cb4601fa1cb6426ae26f7a37
ToppCell	10x5'-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	GHSR PACSIN1 FAM217A GALNT16	4.04e-04	166	93	4	ba42349a68b22e91a0340bda1ccecd6c7592392f
Drug	Enalapril	TGFB1 MPO THBS4 HYAL1 APOE HAS2 ACE	8.27e-07	131	89	7	ctd:D004656
Drug	AC1NPJ0Q	MPO MAN2A1 GRK5 GRK6 GBE1	1.06e-05	74	89	5	CID005159167
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; MCF7; HT_HG-U133A	MYO9B PIK3CD GRK5 ATP11A BRINP1 APOE TBC1D17	1.32e-05	199	89	7	3287_UP
Drug	8,12-iso-isoprostane F2alpha-VI	APOE ALOX15	1.51e-05	2	89	2	ctd:C115626
Drug	carvedilol	TGFB1 MPO GRK5 GRK6 UGT2B4 ACE	1.57e-05	136	89	6	ctd:C043211
Disease	Cardiovascular Diseases	MPO GRK5 APOE ACE	4.04e-06	36	88	4	C0007222
Disease	H/O: depression	TGFB1 ACE	8.79e-06	2	88	2	C0455503
Disease	dementia, Parkinson disease, disease progression measurement	APOE LRP1B	2.63e-05	3	88	2	EFO_0008336, MONDO_0001627, MONDO_0005180
Disease	phenylketonuria (implicated_via_orthology)	DUOX1 DUOX2	5.26e-05	4	88	2	DOID:9281 (implicated_via_orthology)
Disease	neuritic plaque measurement, cerebral amyloid angiopathy	APOE NCK2	5.26e-05	4	88	2	EFO_0006790, EFO_0006798
Disease	hypertension (biomarker_via_orthology)	TGFB1 GRK5 ENTPD2 APOE SLC4A4 ACE	6.22e-05	227	88	6	DOID:10763 (biomarker_via_orthology)
Disease	Duchenne and Becker Muscular Dystrophy	TGFB1 DMD	8.74e-05	5	88	2	C3542021
Disease	Becker Muscular Dystrophy	TGFB1 DMD	8.74e-05	5	88	2	C0917713
Disease	level of Sphingomyelin (d42:2) in blood serum	APOE SLC4A4 ALOX15	8.85e-05	29	88	3	OBA_2045183
Disease	level of Sphingomyelin (d40:1) in blood serum	APOE SLC4A4 ALOX15	1.19e-04	32	88	3	OBA_2045182
Disease	Muscular Dystrophy, Duchenne	TGFB1 DMD	1.31e-04	6	88	2	C0013264
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	TDRD15 SPATA17 APOE	1.43e-04	34	88	3	EFO_0008317, EFO_0008596, EFO_0020944
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD6	1.83e-04	7	88	2	DOID:0050834 (implicated_via_orthology)
Disease	neuritic plaque measurement, neurofibrillary tangles measurement	APOE NCK2	1.83e-04	7	88	2	EFO_0006797, EFO_0006798
Disease	Early-onset autosomal dominant Alzheimer disease	MPO APOE	1.83e-04	7	88	2	cv:CN043596
Disease	myocardial infarction (is_implicated_in)	TGFB1 APOE FTO ACE	2.24e-04	99	88	4	DOID:5844 (is_implicated_in)
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	TDRD15 APOE	2.43e-04	8	88	2	EFO_0008589, EFO_0008595
Disease	obstructive sleep apnea (biomarker_via_orthology)	GHSR ACE	2.43e-04	8	88	2	DOID:0050848 (biomarker_via_orthology)
Disease	Alzheimer disease	MPO APOE	2.43e-04	8	88	2	cv:C0002395
Disease	end stage renal disease (is_implicated_in)	MPO SLC9A5 ACE	2.52e-04	41	88	3	DOID:783 (is_implicated_in)
Disease	systemic lupus erythematosus (implicated_via_orthology)	MAN2A1 DEF6 RUBCN	2.90e-04	43	88	3	DOID:9074 (implicated_via_orthology)
Disease	Proteinuria	TGFB1 APOE NCK2	2.90e-04	43	88	3	C0033687
Disease	liver fat measurement	HAVCR2 APOE LMBRD1	2.90e-04	43	88	3	EFO_0010821
Disease	angiotensin-converting enzyme measurement	SLC48A1 ACE	3.12e-04	9	88	2	EFO_0006515
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX1 DUOX2	3.12e-04	9	88	2	DOID:0050338 (implicated_via_orthology)
Disease	middle cerebral artery infarction (implicated_via_orthology)	GHSR APOE ACE	3.32e-04	45	88	3	DOID:3525 (implicated_via_orthology)
Disease	glomerulosclerosis (implicated_via_orthology)	APOE ACE	4.75e-04	11	88	2	DOID:0050851 (implicated_via_orthology)
Disease	Berylliosis	TGFB1 ACE	4.75e-04	11	88	2	C0005138
Disease	Beryllium Disease	TGFB1 ACE	4.75e-04	11	88	2	C2350873
Disease	visual epilepsy (is_implicated_in)	ASPM TBC1D24	4.75e-04	11	88	2	DOID:11832 (is_implicated_in)
Disease	Occupational Diseases	TGFB1 MPO	4.75e-04	11	88	2	C0028797
Disease	pulmonary fibrosis (implicated_via_orthology)	TGFB1 ACE	5.69e-04	12	88	2	DOID:3770 (implicated_via_orthology)
Disease	persulfide dioxygenase ETHE1, mitochondrial measurement	GRK6 SLC48A1	5.69e-04	12	88	2	EFO_0008258
Disease	familial hyperlipidemia (implicated_via_orthology)	TGFB1 APOE	5.69e-04	12	88	2	DOID:1168 (implicated_via_orthology)
Disease	Acute Cerebrovascular Accidents	TGFB1 SH3PXD2A ACE	5.70e-04	54	88	3	C0751956
Disease	Antithrombotic agent use measurement	TDRD15 APOE FTO	6.01e-04	55	88	3	EFO_0009925
Disease	transmembrane protein 87B measurement	GRK6 SLC48A1	6.71e-04	13	88	2	EFO_0802158
Disease	tRNA (guanine-N(7)-)-methyltransferase measurement	GRK6 APOE	6.71e-04	13	88	2	EFO_0802162
Disease	hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	6.71e-04	13	88	2	DOID:1459 (implicated_via_orthology)
Disease	gallbladder cancer (is_implicated_in)	APOE LRP1B	6.71e-04	13	88	2	DOID:3121 (is_implicated_in)
Disease	multiple myeloma (is_implicated_in)	TGFB1 APOE ACE	7.38e-04	59	88	3	DOID:9538 (is_implicated_in)
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	7.82e-04	14	88	2	DOID:0050328 (implicated_via_orthology)
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	TDRD15 APOE	7.82e-04	14	88	2	EFO_0004611, EFO_0008589
Disease	neutrophil count	MPO KDELR2 C12orf71 PTPN14 MYO1C MICAL2 DEF6 NIPSNAP2 CHD9 FTO SLC4A4 GALNT16	8.10e-04	1382	88	12	EFO_0004833
Disease	Cerebrovascular accident	TGFB1 SH3PXD2A ACE	8.54e-04	62	88	3	C0038454
Disease	osteoarthritis, hip, osteoarthritis, knee	TGFB1 NOG FTO	8.54e-04	62	88	3	EFO_0004616, EFO_1000786
Disease	chronic obstructive pulmonary disease (is_implicated_in)	TGFB1 ACE LRP1B	8.94e-04	63	88	3	DOID:3083 (is_implicated_in)
Disease	low density lipoprotein triglyceride measurement	TDRD15 APOE	9.00e-04	15	88	2	EFO_0009946
Disease	response to statin, LDL cholesterol change measurement	TDRD15 APOE	9.00e-04	15	88	2	EFO_0007804, GO_0036273
Disease	obesity (biomarker_via_orthology)	TGFB1 DRD4 FTO ACE	9.97e-04	147	88	4	DOID:9970 (biomarker_via_orthology)
Disease	obstructive sleep apnea	PACSIN1 APOE FTO	1.02e-03	66	88	3	EFO_0003918
Disease	Urticaria	TGFB1 MPO	1.03e-03	16	88	2	C0042109
Disease	Alcohol abuse	GHSR DRD4 APOE	1.07e-03	67	88	3	C0085762
Disease	autism spectrum disorder (implicated_via_orthology)	EIF4E1B CHD9 BRINP1 CHD6	1.13e-03	152	88	4	DOID:0060041 (implicated_via_orthology)
Disease	Renal Insufficiency	APOE ACE	1.16e-03	17	88	2	C1565489
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 APOE	1.16e-03	17	88	2	EFO_0022232
Disease	renal cell carcinoma (is_implicated_in)	TGFB1 HAVCR2 FTO	1.16e-03	69	88	3	DOID:4450 (is_implicated_in)
Disease	fibrinogen measurement, coronary artery disease	TGFB1 TDRD15 CHD9 APOE	1.18e-03	154	88	4	EFO_0001645, EFO_0004623
Disease	Alcoholic Intoxication, Chronic	GHSR DRD4 APOE FTO ACE	1.26e-03	268	88	5	C0001973
Disease	transient cerebral ischemia (biomarker_via_orthology)	GHSR HAVCR2 APOE FTO	1.27e-03	157	88	4	DOID:224 (biomarker_via_orthology)
Disease	sphingosine 1-phosphate measurement	DMD FTO	1.30e-03	18	88	2	EFO_0800185
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	TDRD15 APOE	1.30e-03	18	88	2	EFO_0008317, EFO_0008589
Disease	type 1 diabetes mellitus (is_marker_for)	TGFB1 APOE ACE	1.32e-03	72	88	3	DOID:9744 (is_marker_for)
Disease	complex trait	TDRD15 SUGP2 CHD6 APOE FTO	1.33e-03	271	88	5	EFO_0010578
Disease	lung cancer (is_implicated_in)	MPO ACE LRP1B	1.43e-03	74	88	3	DOID:1324 (is_implicated_in)
Disease	neck circumference	NOG FTO	1.45e-03	19	88	2	EFO_0011043
Disease	renovascular hypertension (biomarker_via_orthology)	MPO ACE	1.45e-03	19	88	2	DOID:1591 (biomarker_via_orthology)
Disease	Lung diseases	TGFB1 MPO ACE	1.66e-03	78	88	3	C0024115
Disease	complement factor H-related protein 3 measurement	ASPM FUT9 GBE1 DMD	1.67e-03	169	88	4	EFO_0600056
Disease	sexual dimorphism measurement	GHSR MMP24 NOG KIF1A PACSIN1 MYO9B DEF6 APOE FTO ECI1	1.68e-03	1106	88	10	EFO_0021796
Disease	COVID-19, mortality	APOE FTO LRP1B GALNT16	1.70e-03	170	88	4	EFO_0004352, MONDO_0100096
Disease	cardiovascular system disease (is_implicated_in)	MPO FTO	1.78e-03	21	88	2	DOID:1287 (is_implicated_in)
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	TGFB1 NOG	1.78e-03	21	88	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	pulmonary hypertension (biomarker_via_orthology)	HYAL1 HAS2 HAS3	1.78e-03	80	88	3	DOID:6432 (biomarker_via_orthology)
Disease	liver cirrhosis (is_marker_for)	TGFB1 ENTPD2 ACE	1.91e-03	82	88	3	DOID:5082 (is_marker_for)
Disease	lung disease (is_implicated_in)	TGFB1 MPO	1.95e-03	22	88	2	DOID:850 (is_implicated_in)
Disease	Kidney Failure	APOE ACE	1.95e-03	22	88	2	C0035078
Disease	clinical and behavioural ideal cardiovascular health	APOE FTO	2.14e-03	23	88	2	EFO_0007654
Disease	hepatocellular carcinoma (is_implicated_in)	MPO HAVCR2 ACE LRP1B	2.14e-03	181	88	4	DOID:684 (is_implicated_in)
Disease	non-alcoholic fatty liver disease	APOE FTO SLC4A4 LMBRD1	2.18e-03	182	88	4	EFO_0003095
Disease	liver fibrosis measurement	TGFB1 TDRD15 APOE	2.19e-03	86	88	3	EFO_0010576
Disease	Coronary heart disease	APOE ACE	2.33e-03	24	88	2	C0010068
Disease	partial thromboplastin time	GRK6 SLC48A1	2.33e-03	24	88	2	EFO_0004310
Disease	Albuminuria	ACE NCK2	2.33e-03	24	88	2	C0001925
Disease	traumatic brain injury (biomarker_via_orthology)	TGFB1 FTO	2.33e-03	24	88	2	DOID:0081292 (biomarker_via_orthology)
Disease	Kidney Diseases	TGFB1 MPO ACE	2.34e-03	88	88	3	C0022658
Disease	Prostatic Neoplasms	TGFB1 MPO PLEK2 PIK3CD CHD6 ACE LRP1B	2.47e-03	616	88	7	C0033578
Disease	Malignant neoplasm of prostate	TGFB1 MPO PLEK2 PIK3CD CHD6 ACE LRP1B	2.47e-03	616	88	7	C0376358
Disease	interstitial lung disease (is_marker_for)	TGFB1 MPO	2.52e-03	25	88	2	DOID:3082 (is_marker_for)
Disease	response to TNF antagonist, joint damage measurement	BRINP1 FTO	2.52e-03	25	88	2	EFO_0004653, EFO_0005413
Disease	Brain Diseases	TGFB1 MPO	2.52e-03	25	88	2	C0006111
Disease	Hypertensive disease	TGFB1 APOE ACE ALOX15	2.55e-03	190	88	4	C0020538
Disease	atopic dermatitis (is_implicated_in)	TGFB1 APOE	2.73e-03	26	88	2	DOID:3310 (is_implicated_in)
Disease	level of Sterol ester (27:1/18:2) in blood serum	TDRD15 APOE	2.73e-03	26	88	2	OBA_2045194
Disease	Depressive Symptoms	TGFB1 ACE	2.73e-03	26	88	2	C0086132
Disease	alcohol use disorder (implicated_via_orthology)	EPS8L2 PIK3CD GRK5 GRK6	2.80e-03	195	88	4	DOID:1574 (implicated_via_orthology)
Disease	Myocardial Infarction	TGFB1 APOE ACE	2.91e-03	95	88	3	C0027051
Disease	Nephrotic Syndrome	TGFB1 NCK2	2.94e-03	27	88	2	C0027726
Disease	chronic myeloid leukemia (is_marker_for)	TGFB1 ACE	2.94e-03	27	88	2	DOID:8552 (is_marker_for)
Disease	Encephalopathies	TGFB1 MPO	2.94e-03	27	88	2	C0085584

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVDNAYWLWTFQGRL	EIF3B	676	P55884
YWLWTFQGRLLQKNN	EIF3B	681	P55884
GQRWELALGRFWDYL	APOE	41	P02649
LALGRFWDYLRWVQT	APOE	46	P02649
VWNLNHLWGRLRDFY	CCDC88B	91	A6NC98
HWGNDWDLQNRYKLL	BRINP1	331	O60477
YNQEWWSLRLKYQGL	ACE	1086	P12821
LWFLGRAQQYLAAWD	CCDC142	436	Q17RM4
WRRFHYDIKIFNQWL	DMD	2106	P11532
LENWKRLQMRLGYFW	ANO2	456	Q9NQ90
IQALWRGYSWRKKND	ASPM	3211	Q8IZT6
WILGTFYYLWQDNRA	GALNT16	16	Q8N428
EWGNYWARAIRFRQD	NIPSNAP2	201	O75323
AATLIQANWRGYWLR	IQCN	106	Q9H0B3
QANWRGYWLRQKLIS	IQCN	111	Q9H0B3
KYWDGWFRGLSNLFL	PPME1	296	Q9Y570
QALGLLWFRYHNLWA	DUOX1	246	Q9NRD9
WFWRLRNNRVQEGYP	MMP24	401	Q9Y5R2
RWQKGRDLTWYAKGR	MMTAG2	41	Q9BU76
NYIFWSDWGRRAILR	LRP1B	2416	Q9NZR2
KTLEFFWRQNWDLGS	MAN2A1	326	Q16706
KTWWRVRNAANRTGY	NCK2	36	O43639
LQKFYRGEFRWLWRQ	NADK2	206	Q4G0N4
FEWLRQFWFQGNRYR	FTO	376	Q9C0B1
RNIGIWFFWIRLYKI	LMBRD1	386	Q9NUN5
NRWALWFFKNDRSRA	EIF4E1B	66	A6NMX2
FNWRKDFTVNLPRFW	FUT9	316	Q9Y231
LLWFRYHNLWAQRLA	DUOX2	256	Q9NRD8
LLENFIKYGWVGRWF	ENTPD2	176	Q9Y5L3
FRLWWHYGISFLRLQ	PCYOX1L	131	Q8NBM8
WYELQARDWPLKNQA	KSR1	811	Q8IVT5
GTQFRKLRDGDRFWW	MPO	666	P05164
SSWDGNLRLWQYRQA	DCAF11	501	Q8TEB1
RKLYRWGNWKDGLIL	ALOX15	136	P16050
LYWATFRGLQRWEVA	DRD4	211	P21917
RQWWKLRSRSGQAGY	EPS8L2	526	Q9H6S3
QDYWRTWLKGLRGFF	SLC48A1	61	Q6P1K1
YGQQLTDWAKRWRQL	PACSIN1	56	Q9BY11
YAGYWKAVQELWLRL	ECI1	121	P42126
REYQLEGLNWLLFNW	CHD9	861	Q3L8U1
FRVEKNLLVYGWGRW	CHD9	1496	Q3L8U1
NIRWWLEEYRFDGFR	GBE1	341	Q04446
YGADWSWLLFRSLQR	DPH7	336	Q9BTV6
VRLWQYRPWNFGDLL	GHSR	101	Q92847
LEGMNWLLFNWYNRK	CHD6	466	Q8TD26
RWLNQQTRWSKSYFR	HAS2	346	Q92819
GYLWKRGHLRRNWAE	DEF6	221	Q9H4E7
LLFRFSAQEQRWWAG	KLHDC7A	646	Q5VTJ3
RWAFNWDTKDIYRQR	HYAL1	136	Q12794
RWSKSYFREWLYNSL	HAS3	356	O00219
ALKRNWSNAGKYRWN	FAM217A	366	Q8IXS0
FFDRFLQWKWLERQP	GRK5	166	P34947
YFNRFLQWKWLERQP	GRK6	166	P43250
RRQTDYWQFVKDIRW	RUBCN	76	Q92622
GLYRALYLVNWIWRF	KDELR2	156	P33947
LTFGNSTRRAYWKEW	FAM166A	296	Q6J272
WYQFTSLRDLLWGNA	KIF1A	716	Q12756
PSKYQNWRREFWWSL	MICAL2	1241	O94851
KTQGLRWPWQAAIYR	PAMR1	456	Q6UXH9
KAYAQQLADWARKWR	PACSIN3	51	Q9UKS6
WNDLGSRFWPRYVKV	NOG	161	Q13253
IIQKWWRSFLGRKQY	SPATA17	61	Q96L03
LFSWTRKAFRDLWNF	TDRD15	876	B5MCY1
NYWTSRYWLNGDFRK	HAVCR2	76	Q8TDQ0
PRLWQESFWKNYSQL	SPATA31A7	401	Q8IWB4
YFGLWFLSKSQQARW	PTPN14	61	Q15678
WRDRWEQFDKKYLSQ	SLC9A5	496	Q14940
WNLGFQLSRWNYKSL	SI	351	P14410
FRLPKERSLSYWWNR	BRINP2	406	Q9C0B6
LNFGWAFSWLRQRIL	C12orf71	211	A8MTZ7
RWRVFIYWTLLGLFD	ATP11A	961	P98196
LQVYADWQRWLFGEL	TBC1D24	206	Q9ULP9
PRLWQESFWKNYSQL	SPATA31A3	401	Q5VYP0
RNVGWKDKVSYRWFL	THBS4	871	P35443
RREAWKFLLGYLSWE	TBC1D17	316	Q9HA65
WKARWFILRQNTLVY	PLEK2	21	Q9NYT0
NWRQVFGDEKKYWLL	ZDHHC20	266	Q5W0Z9
PRLWQESFWKNYSQL	SPATA31A1	401	Q5TZJ5
PRLWQESFWKNYSQL	SPATA31A5	401	Q5VU36
AKADIWLIRNYWDFQ	UGT2B4	251	P06133
IRKNLEGWWYIRYLG	SH3PXD2A	296	Q5TCZ1
RQLYIDFRKDLGWKW	TGFB1	296	P01137
FRSQDWKFALRGSWE	SUGP2	131	Q8IX01
RFWLFWKYPQEQDRN	SLC50A1	201	Q9BRV3
RKSWENSGFWSRLEY	MYCBPAP	261	Q8TBZ2
AARRQQLGWEAWLQY	PIK3CD	151	O00329
LRKQAWKFLLGYFPW	TBC1D15	351	Q8TC07
LRAFQAWQKARSDGW	YTHDC2	901	Q9H6S0
NNFDYLEFRLWIGLW	SLC4A4	546	Q9Y6R1
WRSLWIRFGYDPRKN	GTF3C5	296	Q9Y5Q8
GTAKWAWLRRGLYYL	TTC37	561	Q6PGP7
RYLQTYGEWNRAAWL	WDR11	1081	Q9BZH6
KWGKLRDYQVRGLNW	SMARCA5	176	O60264
YNVWLRAQLGWKSFL	RNF145	496	Q96MT1
WREWLGLIKNSRFYN	SULF1	156	Q8IWU6
YWRDLLRIQFWIGAV	TMEM87A	251	Q8NBN3
QYYGWNIGKRRAAEW	YEATS2	1181	Q9ULM3
IQAAWRGFHWRQKFL	MYO1C	741	O00159
WWRGYCNRRNFKLIL	MYO7B	796	Q6PIF6
SWRGYWQRKLYRHQK	MYO9B	1011	Q13459