Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	Fanconi anaemia nuclear complex	FANCM FAAP100 FANCG	5.67e-05	15	107	3	GO:0043240
GeneOntologyCellularComponent	SREBP-SCAP-Insig complex	SREBF2 INSIG2	7.76e-05	3	107	2	GO:0032937
HumanPheno	Aplasia/Hypoplasia of the cerebellar vermis	NPHP1 CACNA1A INTS1 WDR81 TSEN54 THOC2 NCAPG2 PEX16 CC2D2A VPS51 HTT	2.12e-05	369	35	11	HP:0006817
HumanPheno	Cerebellar vermis hypoplasia	NPHP1 CACNA1A INTS1 WDR81 TSEN54 THOC2 NCAPG2 PEX16 CC2D2A VPS51 HTT	2.12e-05	369	35	11	HP:0001320
HumanPheno	Abnormal cerebellar vermis morphology	NPHP1 CACNA1A INTS1 WDR81 TSEN54 THOC2 NCAPG2 PEX16 CC2D2A VPS51 HTT	2.41e-05	374	35	11	HP:0002334
HumanPheno	Cerebellar malformation	NPHP1 CACNA1A INTS1 WDR81 POR TSEN54 THOC2 NCAPG2 PEX16 CC2D2A VPS51 HTT	5.45e-05	487	35	12	HP:0002438
Domain	-	LRRC10 PRAMEF12 LRRC47 LRFN4 AMIGO3 LRRC8A ZER1 LRRC8B PRAME	1.03e-04	321	108	9	3.80.10.10
Domain	L_dom-like	LRRC10 PRAMEF12 LRRC47 LRFN4 AMIGO3 LRRC8A ZER1 LRRC8B PRAME	1.21e-04	328	108	9	IPR032675
Domain	ARM-type_fold	INTS1 NCAPG2 ARMC1 ITPR2 UPF2 INF2 EIF2B5 ZER1 HTT	1.55e-04	339	108	9	IPR016024
Domain	LRR_1	LRRC10 LRRC47 LRFN4 AMIGO3 LRRC8A LRRC8B PRAME	2.83e-04	219	108	7	PF00560
Domain	LRRC8_Pannexin-like	LRRC8A LRRC8B	3.28e-04	5	108	2	IPR021040
Domain	Pannexin_like	LRRC8A LRRC8B	3.28e-04	5	108	2	PF12534
Domain	LRR_8	LRRC10 LRRC47 LRFN4 AMIGO3 LRRC8A LRRC8B	4.78e-04	171	108	6	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC10 LRRC47 LRFN4 AMIGO3 LRRC8A LRRC8B	5.73e-04	177	108	6	IPR003591
Domain	LRR_TYP	LRRC10 LRRC47 LRFN4 AMIGO3 LRRC8A LRRC8B	5.73e-04	177	108	6	SM00369
Domain	Leu-rich_rpt	LRRC10 LRRC47 LRFN4 AMIGO3 LRRC8A LRRC8B PRAME	1.00e-03	271	108	7	IPR001611
Domain	DNA/RNA_helicase_DEAH_CS	EP400 DHX57 FANCM	1.08e-03	35	108	3	IPR002464
Domain	DEAH_ATP_HELICASE	EP400 DHX57 FANCM	1.37e-03	38	108	3	PS00690
Domain	MIF4-like	UPF2 EIF2B5	3.31e-03	15	108	2	IPR016021
Domain	-	UPF2 EIF2B5	3.31e-03	15	108	2	1.25.40.180
Domain	Helicase_C	EP400 DHX57 FANCM DICER1	3.46e-03	107	108	4	PF00271
Domain	HELICc	EP400 DHX57 FANCM DICER1	3.46e-03	107	108	4	SM00490
Domain	Helicase_C	EP400 DHX57 FANCM DICER1	3.57e-03	108	108	4	IPR001650
Domain	HELICASE_CTER	EP400 DHX57 FANCM DICER1	3.69e-03	109	108	4	PS51194
Domain	HELICASE_ATP_BIND_1	EP400 DHX57 FANCM DICER1	3.69e-03	109	108	4	PS51192
Domain	DEXDc	EP400 DHX57 FANCM DICER1	3.69e-03	109	108	4	SM00487
Domain	Helicase_ATP-bd	EP400 DHX57 FANCM DICER1	3.82e-03	110	108	4	IPR014001
Domain	GPCR_2_secretin-like	ADGRG3 ADGRB2 FZD6	5.07e-03	60	108	3	IPR000832
Domain	GPCR_2-like	ADGRG3 ADGRB2 FZD6	5.07e-03	60	108	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRG3 ADGRB2 FZD6	5.31e-03	61	108	3	PS50261
Domain	PRAME_family	PRAMEF12 PRAME	5.31e-03	19	108	2	IPR026271
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EP400 TMC6 INTS1 ADGRB2 MED13L FAAP100 ITPR2 PLCD3 AATK SH3TC1 INF2 IL17RE ZER1 MICAL3 ABCC10 HTT	4.67e-07	1105	111	16	35748872
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	EP400 MED13L FANCM THOC2 FAAP100 NCAPG2 ASH2L FANCG MDC1 PRAME	2.03e-06	453	111	10	29656893
Pubmed	FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.	FANCM FAAP100 FANCG	2.62e-06	9	111	3	17396147
Pubmed	Modularized functions of the Fanconi anemia core complex.	FANCM FAAP100 FANCG	3.74e-06	10	111	3	24910428
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	SREBF2 WDR81 POR DHX57 ITPR2 TMEM161A VPS13D INF2 C9orf72 DOP1B	5.21e-06	504	111	10	34432599
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR4 ADGRG3 ADGRB2 GPR142 GPR62	5.65e-06	79	111	5	12679517
Pubmed	A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.	FANCM FAAP100 FANCG	6.82e-06	12	111	3	16116422
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SREBF2 DHX57 NCAPG2 DICER1 ASH2L TMEM33 PLCD3 TMEM62 UPF2 EIF2B5 MICAL3	7.80e-06	650	111	11	38777146
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	SREBF2 MED13L DICER1 ASH2L TMEM161A VPS13D LRRC8A PEAK1 SNAPC3 ANKRD52	8.91e-06	536	111	10	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	SREBF2 MED13L DICER1 ASH2L TMEM161A VPS13D LRRC8A PEAK1 SNAPC3 ANKRD52	9.21e-06	538	111	10	10512203
Pubmed	Molecular characterization of DICER1-mutated pituitary blastoma.	DICER1 PRAME	1.01e-05	2	111	2	33644822
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	CHST14 PSMB2 SREBF2 POR NCAPG2 TMEM33 LRRC47 FZD6 GLA INF2 EIF2B5 VPS51 HSPA14	1.01e-05	942	111	13	31073040
Pubmed	MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.	FANCM FAAP100 FANCG	1.12e-05	14	111	3	20347429
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	SLC39A1 TMC6 TMEM33 SLC32A1 TMEM161A TMEM62 AATK INF2 MDC1 PEX16 HTT	1.49e-05	697	111	11	28298427
Pubmed	A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.	FANCM FAAP100 FANCG	1.72e-05	16	111	3	20347428
Pubmed	Defining the membrane proteome of NK cells.	CNST PSMB2 INTS1 POR NCAPG2 ITPR2 INTS2 GLG1 PAFAH1B3 PEX16 LRRC8A CNOT1 HSPA14 PSD4	2.18e-05	1168	111	14	19946888
Pubmed	FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.	FANCM FAAP100 FANCG	2.49e-05	18	111	3	22343915
Pubmed	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.	SREBF2 HTT	3.02e-05	3	111	2	31875875
Pubmed	A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.	FANCM FAAP100 FANCG	3.47e-05	20	111	3	22705371
Pubmed	Fanconi Anemia	FANCM FAAP100 FANCG	5.35e-05	23	111	3	20301575
Pubmed	The Repeat Expansion Diseases: The dark side of DNA repair.	CACNA1A C9orf72 HTT	5.35e-05	23	111	3	26002199
Pubmed	Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.	SREBF2 INSIG2	6.03e-05	4	111	2	19110480
Pubmed	Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.	SREBF2 INSIG2	6.03e-05	4	111	2	19740467
Pubmed	Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs.	SREBF2 INSIG2	6.03e-05	4	111	2	12842885
Pubmed	Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.	LRRC8A LRRC8B	6.03e-05	4	111	2	28193731
Pubmed	Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.	ITPR2 HTT	6.03e-05	4	111	2	33086039
Pubmed	Multilocus genotypic association with vascular dementia by multifactor dimensionality reduction and entropy-based estimation.	SREBF2 AGT	6.03e-05	4	111	2	19550366
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PSMB2 ASCC1 POR NCAPG2 DICER1 ARMC1 TMEM33 ITPR2 LRRC47 INF2 GLG1 PEAK1 C9orf72 ANKRD52 HSPA14	7.82e-05	1487	111	15	33957083
Pubmed	Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.	LRRC8A LRRC8B	1.00e-04	5	111	2	35777784
Pubmed	Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?	SREBF2 INSIG2	1.00e-04	5	111	2	18195716
Pubmed	LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.	LRRC8A LRRC8B	1.00e-04	5	111	2	15094057
Pubmed	Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway.	FANCM FANCG	1.00e-04	5	111	2	21975120
Pubmed	Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.	LRRC8A LRRC8B	1.00e-04	5	111	2	24790029
Pubmed	Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.	SREBF2 INSIG2	1.00e-04	5	111	2	16100574
Pubmed	Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.	FANCM FANCG	1.00e-04	5	111	2	18174376
Pubmed	Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.	SREBF2 INSIG2	1.00e-04	5	111	2	12242332
Pubmed	Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.	APEX1 HTT	1.00e-04	5	111	2	19997493
Pubmed	The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.	SREBF2 INSIG2	1.00e-04	5	111	2	25028659
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	FANCM FANCG MDC1	1.33e-04	31	111	3	19690177
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	INTS1 UPF2 LRRC8A CC2D2A MICAL3	1.36e-04	153	111	5	10718198
Pubmed	FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair.	FANCM FAAP100	1.50e-04	6	111	2	18285517
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WDR81 INTS2 SH3TC1 ABCC10	1.63e-04	85	111	4	15449545
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PSMB2 ASCC1 DHX57 THOC2 NCAPG2 DICER1 TMEM33 ITPR2 LRRC47 INF2 MDC1 EIF2B5 MICAL3 CNOT1	2.02e-04	1440	111	14	30833792
Pubmed	Candidate Gene of NOS3, MMP3, AGT, and AGT1R and Pathway Analyses for Platelet Reactivity and Clinical Outcomes of Repeat Revascularization After First PCI in Chinese Patients.	ITPR2 AGT	2.10e-04	7	111	2	34860335
Pubmed	Evidence for subcomplexes in the Fanconi anemia pathway.	FANCM FANCG	2.10e-04	7	111	2	16720839
Pubmed	The ins and outs of a polyglutamine neurodegenerative disease: spinocerebellar ataxia type 1 (SCA1).	CACNA1A HTT	2.10e-04	7	111	2	10860780
Pubmed	The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.	FANCM FANCG	2.10e-04	7	111	2	24451376
Pubmed	Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.	NPHP1 CC2D2A	2.79e-04	8	111	2	26540106
Pubmed	Ash2l interacts with Tbx1 and is required during early embryogenesis.	TSEN54 ASH2L	2.79e-04	8	111	2	20463296
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EP400 DICER1 LRRC47 AMIGO3 INTS2 MDC1 LRRC8A CNOT1	3.05e-04	529	111	8	14621295
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	INTS1 MACROD1 SREBF2 MED13L NCAPG2 DICER1 ASH2L UPF2 INTS2 SNAPC3 CNOT1 HSPA14 HTT	3.21e-04	1327	111	13	32694731
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	INTS1 NCAPG2 MICAL3 HTT	3.53e-04	104	111	4	31240132
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EP400 PSMB2 DHX57 NCAPG2 TMEM33 LRRC47 PLCD3 RIN1 UPF2 INF2 MDC1 EIF2B5 ANKRD52	3.86e-04	1353	111	13	29467282
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EP400 THOC2 ASH2L TMEM33 MDC1 PEAK1 CNOT1 HTT	3.90e-04	549	111	8	38280479
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	EP400 AMIGO3 WDR97 HYDIN	3.94e-04	107	111	4	11347906
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CHST14 SLC39A1 APEX1 NCAPG2 ITPR2 FZD6 TMEM161A GLA GLG1 AGT LRRC8A HTT	4.63e-04	1201	111	12	35696571
Pubmed	Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response.	FANCM FAAP100	5.45e-04	11	111	2	26625197
Pubmed	The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.	FAAP100 FANCG	5.45e-04	11	111	2	19965384
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	DUSP4 TMC6 MACROD1 PRAMEF12 MFRP FZD6 INTS2 KLHL30 GLG1 CC2D2A VPS51 DOP1B	6.23e-04	1242	111	12	30973865
Pubmed	Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.	LRRC8A LRRC8B	6.52e-04	12	111	2	32277911
Pubmed	A novel ubiquitin ligase is deficient in Fanconi anemia.	FAAP100 FANCG	6.52e-04	12	111	2	12973351
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CACNA1A POR DHX57 TMEM33 ITPR2 LRRC47 RIN1 UPF2 INF2 MICAL3 PEAK1 VPS51 CNOT1	6.53e-04	1431	111	13	37142655
Pubmed	The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.	EP400 ASH2L	7.69e-04	13	111	2	16510874
Pubmed	Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.	FAAP100 FANCG	7.69e-04	13	111	2	27986371
Pubmed	The environmental and genetic evidence for the association of hyperlipidemia and hypertension.	SREBF2 AGT	7.69e-04	13	111	2	19155782
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	POR TMEM33 ITPR2 TMEM161A INF2 LRRC8A C9orf72	7.80e-04	468	111	7	31056421
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	EP400 INTS1 ASH2L LRRC47 INTS2 CNOT1 HYDIN	7.90e-04	469	111	7	27634302
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	EP400 INTS1 ITPR2 UPF2 MDC1 EIF2B5	8.12e-04	341	111	6	32971831
Pubmed	Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.	CHDH PEX16 ZER1	8.59e-04	58	111	3	24144296
Pubmed	Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.	FZD6 LRFN4 EIF2B5 LRRC8B	8.67e-04	132	111	4	26439863
Pubmed	The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts.	INTS1 INTS2	8.96e-04	14	111	2	32697989
Pubmed	Structure of the catalytic core of the Integrator complex.	INTS1 INTS2	8.96e-04	14	111	2	33548203
Pubmed	INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.	INTS1 INTS2	8.96e-04	14	111	2	32647223
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	ASH2L MDC1 CNOT1	9.03e-04	59	111	3	28813667
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	NPHP1 WDR81 MFRP DICER1 CC2D2A	9.31e-04	233	111	5	32290105
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EP400 PSMB2 INTS1 ASCC1 APEX1 DHX57 DICER1 ASH2L PLCD3 TMEM161A INTS2 GLG1 MDC1	9.87e-04	1497	111	13	31527615
Pubmed	The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.	FANCM FANCG	1.03e-03	15	111	2	19536649
Pubmed	Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.	FANCM FANCG	1.03e-03	15	111	2	17289582
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	EP400 ASH2L	1.03e-03	15	111	2	16510875
Pubmed	Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.	APEX1 FANCG	1.03e-03	15	111	2	16609022
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FANCM PLCD3 VPS13D RHOBTB1 CNTNAP4 MICAL3 PEAK1	1.05e-03	493	111	7	15368895
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	NPHP1 FAAP100 NCAPG2 DICER1 LRRC47 RIN1 TMEM161A GLA EIF2B5 VPS51 CNOT1 PRAME	1.06e-03	1321	111	12	27173435
Pubmed	Esophageal Atresia / Tracheoesophageal Fistula Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	FANCM FANCG	1.18e-03	16	111	2	20301753
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	FANCM MDC1	1.18e-03	16	111	2	27760317
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	INTS1 DHX57 THOC2 DICER1 LRRC47 MDC1 ANKRD52 CNOT1	1.20e-03	653	111	8	22586326
Pubmed	DNA sequence and analysis of human chromosome 9.	TTC16 FANCG LRRC8A ZER1 SNAPC3 C9orf72	1.23e-03	370	111	6	15164053
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	CHST14 INTS1 TMEM161A AMIGO3 IL17RE LRRC8A ENPP5 LRRC8B FCRL5 ANKRD52	1.24e-03	985	111	10	12975309
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	EP400 INTS1 ASH2L CNOT1	1.26e-03	146	111	4	23892456
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	POR ITPR2 FZD6 INF2 EIF2B5 CNOT1	1.32e-03	375	111	6	32788342
Pubmed	Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages.	SLC32A1 CNTNAP4	1.33e-03	17	111	2	26389685
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	EP400 THOC2 CNOT1	1.42e-03	69	111	3	28481362
Pubmed	Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.	CYP24A1 WDR81	1.49e-03	18	111	2	24068962
Pubmed	An interactive association of common sequence variants in the neuropeptide Y gene with susceptibility to ischemic stroke.	SREBF2 AGT	1.49e-03	18	111	2	17702963
Pubmed	Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.	SREBF2 INSIG2	1.49e-03	18	111	2	29899135
Pubmed	Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.	NPHP1 CC2D2A	1.49e-03	18	111	2	21068128
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	ASCC1 WDR81 ASH2L FANCG UPF2 EIF2B5 RASSF3 SNAPC3 ANKRD52 CNOT1	1.83e-03	1038	111	10	26673895
Pubmed	Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.	APEX1 FANCG	1.85e-03	20	111	2	16195237
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	SREBF2 FAAP100 ZER1 SEPTIN12	2.11e-03	168	111	4	30631154
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	CHST14 INTS1 NCAPG2 DICER1 LRRC47 FANCG LRFN4 INTS2 LRRC8A ABCC10	2.14e-03	1061	111	10	33845483
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	CNST WDR81 HYDIN	2.17e-03	80	111	3	19389623
Interaction	FAAP24 interactions	APEX1 FANCM FAAP100 FANCG	9.17e-06	26	104	4	int:FAAP24
Interaction	TOP3B interactions	EP400 TMC6 INTS1 ADGRB2 DHX57 MED13L THOC2 FAAP100 ITPR2 PLCD3 AATK UPF2 SH3TC1 INF2 IL17RE MDC1 ZER1 MICAL3 CNOT1 ABCC10 HTT	1.67e-05	1470	104	21	int:TOP3B
Interaction	GPR182 interactions	CYP24A1 TMC6 INTS1 SREBF2 NCAPG2 FANCG TMEM161A VPS51 PRAME HTT DOP1B	2.33e-05	455	104	11	int:GPR182
Cytoband	3p21.1	CHDH GLYCTK GPR62	1.47e-04	42	111	3	3p21.1
Cytoband	9q34.11	TTC16 LRRC8A ZER1	2.95e-04	53	111	3	9q34.11
GeneFamily	Volume regulated anion channel subunits	LRRC8A LRRC8B	1.60e-04	5	73	2	1158
GeneFamily	X-linked mental retardation\|RNA helicases	FANCM DICER1	8.64e-04	11	73	2	1168
GeneFamily	Integrator complex	INTS1 INTS2	1.63e-03	15	73	2	1366
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCM FANCG	2.91e-03	20	73	2	548
GeneFamily	G protein-coupled receptors, Class A orphans	GPR4 GPR142 GPR62	3.87e-03	78	73	3	262
GeneFamily	PRAME family	PRAMEF12 PRAME	4.19e-03	24	73	2	686
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPHP1 PLEKHG7 SREBF2 MICAL3 FCRL5 WDR17	2.11e-06	150	111	6	4bdcdce40f54580c7a4e1416b468e657ba8874fc
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP4 PLCD3 RHOBTB1 AMIGO3 PAFAH1B3 ABCC10	3.53e-06	164	111	6	b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP4 PLCD3 RHOBTB1 AMIGO3 PAFAH1B3 ABCC10	3.53e-06	164	111	6	a1e43c6b3e2553f5604100db6e92bf244b70c36d
Disease	Kidney Failure	CYP24A1 GLA INF2 AGT	1.14e-06	22	107	4	C0035078
Disease	Muscle hypotonia	CHST14 INTS1 ASCC1	3.04e-05	17	107	3	C0026827
Disease	Renal Insufficiency	CYP24A1 GLA AGT	3.04e-05	17	107	3	C1565489
Disease	ovary adenocarcinoma (is_marker_for)	CYP24A1 PRAME	3.90e-05	3	107	2	DOID:3713 (is_marker_for)
Disease	Fabry disease (is_implicated_in)	GLA AGT	1.29e-04	5	107	2	DOID:14499 (is_implicated_in)
Disease	Congenital Hydrocephalus	WDR81 HYDIN	3.60e-04	8	107	2	C0020256
Disease	Malignant Head and Neck Neoplasm	FANCM FANCG PRAME	5.51e-04	44	107	3	C0278996
Disease	Mouth Diseases	FANCG HSPA14	8.40e-04	12	107	2	C0026636
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	ACRBP DUSP4 RHOBTB1 C9orf72	1.35e-03	131	107	4	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	ACRBP DUSP4 RHOBTB1 C9orf72	1.35e-03	131	107	4	C4552091
Disease	Juvenile arthritis	ACRBP DUSP4 RHOBTB1 C9orf72	1.35e-03	131	107	4	C3495559
Disease	Juvenile psoriatic arthritis	ACRBP DUSP4 RHOBTB1 C9orf72	1.35e-03	131	107	4	C3714758
Disease	Juvenile-Onset Still Disease	ACRBP DUSP4 RHOBTB1 C9orf72	1.50e-03	135	107	4	C0087031
Disease	breast carcinoma (is_marker_for)	CYP24A1 APEX1 MDC1	1.80e-03	66	107	3	DOID:3459 (is_marker_for)
Disease	Bone marrow hypocellularity	FANCM FANCG	1.92e-03	18	107	2	C1855710
Disease	Familial aplasia of the vermis	NPHP1 CC2D2A	2.37e-03	20	107	2	cv:C0431399
Disease	Myopia	MED13L GPR142 GLG1 CNTNAP4 ZER1 FCRL5	2.84e-03	385	107	6	HP_0000545
Disease	carotid artery disease (is_implicated_in)	SREBF2 AGT	2.87e-03	22	107	2	DOID:3407 (is_implicated_in)
Disease	Etat Marbre	TSEN54 HTT	3.14e-03	23	107	2	C0266487

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLYSCGEHEPLERLL	TMEM62	321	Q0P6H9
RLLPLDHYLVNFTCL	ADGRB2	96	O60241
LSTTNPLRRLCHYIL	CACNA1A	1226	O00555
VYGRDLLRICALPSH	EP400	1766	Q96L91
LLQLPHTEALLVLCY	ACRBP	316	Q8NEB7
VQLYILSFLSPHDLC	FBXO4	66	Q9UKT5
LCPSARHLAVYLLDL	CCNJ	56	Q5T5M9
VHSALLALRYLAECR	ARMC1	56	Q9NVT9
RLHSEAAYKLGPLLC	CNTNAP4	771	Q9C0A0
CDHLTFFALLLRPTL	ADGRG3	246	Q86Y34
PELHLGCALALRFLA	GLA	6	P06280
LLPRLEYNDAISAHC	ASCC1	351	Q8N9N2
LRALSHLYLGCNELA	AMIGO3	156	Q86WK7
RLDYFLLSHSLLPAL	APEX1	281	P27695
CLELLLEHSPFSYLE	ANKRD52	806	Q8NB46
AVCLPSILYRLHCLL	DICER1	1051	Q9UPY3
EAYHSLFLSLLGLCP	EFCAB12	6	Q6NXP0
ALLSYLLPLHCALCA	ADAMTS14	6	Q8WXS8
ACLLLIQPHYASDLD	AGT	331	P01019
ACAYLHPALSRTNLK	CHDH	241	Q8NE62
CLYERVLLALHDRAP	ASH2L	376	Q9UBL3
CKLSDREHPLYLRLV	RASSF3	156	Q86WH2
PLAYHITLVELLAAC	ITPR2	1371	Q14571
YTPVCRALHSLLLRL	PAFAH1B3	201	Q15102
LSSPRCAALHGELYL	KLHL30	461	Q0D2K2
PYLVLLHTLIFLACS	LRRC8A	126	Q8IWT6
HVLYHLPCLQRFDTL	LRRC9	216	Q6ZRR7
SLTSLPCYQHFRRLL	MFRP	506	Q9BY79
ALPHALLAVLSACYL	ABCC10	36	Q5T3U5
LALCAIIHRYRPDLI	MICAL3	551	Q7RTP6
HGLLCDRRLFLDIPY	OAZ3	136	Q9UMX2
RTPGLRDALYLAHLC	GPR62	41	Q9BZJ7
RDALYLAHLCVVDLL	GPR62	46	Q9BZJ7
CRHHLAPYLATLQLD	MED13L	1506	Q71F56
LLCQYHRLDVSLPFV	MDC1	126	Q14676
IDHLCELLPRLQARY	POR	441	P16435
LRNLPEYALLCQEHA	INTS1	2141	Q8N201
YVISLGHALSPRLEC	LMO7DN	61	F2Z398
LFTLPLLHYLEVSGC	LRRC47	46	Q8N1G4
CPHSLLLELLTYLCL	DOP1B	1306	Q9Y3R5
ALENLLFLPCAEHLR	FANCM	1016	Q8IYD8
LCPDVSYRHLGLLIL	IL17RE	446	Q8NFR9
PASLALVATLRHCLL	KCNK7	131	Q9Y2U2
PLDSSRYCALLLPLL	EIF2B5	611	Q13144
LHCEALRGSPLILYR	FCRL5	771	Q96RD9
LLLQLCSGLEHLKPY	PEAK1	1496	Q9H792
TDLYPLLCHLLNITA	ENPP5	371	Q9UJA9
FLPIHCIYQLLRSRS	INTS2	551	Q9H0H0
LRLLATNYPHLCIVD	INTS2	711	Q9H0H0
PGLCLLRFLASEHAL	PLK5	251	Q496M5
LSSLKLVIYDHNPCR	LRRC10	211	Q5BKY1
LRASCLLPELLSALH	FANCG	126	O15287
LCHALTFPSLQRLVY	NSUN5P1	76	Q3KNT7
ANIINHYLCDILPLL	OR8B3	171	Q8NGG8
SAVIGLLYPCIDRHL	INSIG2	81	Q9Y5U4
HLELLAPRRLLYALC	FAAP100	66	Q0VG06
CFAPYHVLLLSRSAI	GPR4	236	P46093
LLAALCIYSPEGHVL	INF2	146	Q27J81
LPLQLFLCTKLHYLD	LRRC8B	671	Q6P9F7
IRASYDLEPSHCLLN	PRAMEF12	461	O95522
FLLTCIFLPLLRGHS	FZD6	6	O60353
LLSHCLLVTLAARFP	HBZ	101	P02008
ALDYRLDPQLQLHCS	GLG1	996	Q92896
PSIIYHCALRGLERL	HTT	2871	P42858
HPAGILYTLLAEACL	HYDIN	3311	Q4G0P3
RYCTSTLRHFLPLLE	CC2D2A	1521	Q9P2K1
DCLHILNRYGLRAAL	GLYCTK	266	Q8IVS8
SVHLGSPCLLEALYR	CYP24A1	106	Q07973
LPLACRLHISEFLYD	DHX57	381	Q6P158
CYLSSLDLLLEHRLR	MACROD1	246	Q9BQ69
LLTVDRYTALCHPLH	GPR142	251	Q7Z601
LLLDCRPFLAHSAGY	DUSP4	46	Q13115
LSFYLPLHRVCVDRL	C9orf72	121	Q96LT7
SRALPLCLHQIAESY	CNST	186	Q6PJW8
TFLLVYHDCVLPLLH	NPHP1	651	O15259
YPLLLSHRVCLQLAG	OR10C1	131	Q96KK4
ANIINHYLCDILPLL	OR8B2	171	Q96RD0
LDLLPFYARLVATLH	UPF2	616	Q9HAU5
VLRLIHEPSAALLAY	HSPA14	166	Q0VDF9
EFLYIARPLLHLLSL	PEX16	221	Q9Y5Y5
CAYCHTRDILLLPLQ	RIN1	146	Q13671
RLHPEEALYLLECGS	TSEN54	111	Q7Z6J9
AYLHARLRELLCELG	PRAME	461	P78395
PYRCLLHSLTHFALE	TMEM229A	91	B2RXF0
RLAVTRPHLQAYLCL	TMEM161A	326	Q9NX61
PYRALKHSNLLQCLA	AATK	176	Q6ZMQ8
SLIHLCLALRIPFYR	OR5L1	156	Q8NGL2
LLVARLHCPSDALDL	PSD4	981	Q8NDX1
CLRSRTPYHVNLLLA	PSMB2	91	P49721
LLLADIYSRKCLPHL	SH3TC1	711	Q8TE82
APATHYALELLARKC	WDR17	1001	Q8IZU2
ALANRFCLPHLVALA	RHOBTB1	561	O94844
HDDCLDRTLYPLLIK	SNAPC3	331	Q92966
LHYHLCSAPRALLQD	CHST14	336	Q8NCH0
YLLTHPKNRECLLSA	NCAPG2	766	Q86XI2
ADADLLLRYRECHLL	CNOT1	1676	A5YKK6
PALLLLLSRLCLDYE	VPS51	521	Q9UID3
LFENSLCRLTHIPAY	ZER1	331	Q7Z7L7
LDDLYVHLLPADNCI	THOC2	281	Q8NI27
PELSALAVYCHATRL	PLCD3	526	Q8N3E9
LATCLLDLLPDYLAA	SLC39A1	81	Q9NY26
LALGSRLCLVSHRLY	WDR97	746	A6NE52
ATAILLACRHLPLSF	SREBF2	1081	Q12772
CEFPLLRDLLIRSHL	SEPTIN12	281	Q8IYM1
AADYLCHPLLLLNSE	PLEKHG7	206	Q6ZR37
RYACVLALHSLGLAL	TMC6	206	Q7Z403
HLCYRDLHSALLLNP	TTC16	221	Q8NEE8
AGLCFLLPSLFHLRL	SLC32A1	466	Q9H598
LLYALGPHLLAYRCL	TM6SF2	341	Q9BZW4
YCSALFVLPLLGLHE	TMEM33	36	P57088
LSCLLHIARLYGEPV	WDR81	1296	Q562E7
EHELARSLSPLLFCY	VPS13D	3311	Q5THJ4
LKHLVPGADYDLCLL	LRFN4	461	Q6PJG9