Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear import signal receptor activity	RANBP6 KPNA6 IPO4	2.03e-04	20	116	3	GO:0061608
GeneOntologyMolecularFunction	purine ribonucleotide transmembrane transporter activity	SLC25A42 SLC25A25 ABCD1	3.11e-04	23	116	3	GO:0005346
GeneOntologyMolecularFunction	adenine nucleotide transmembrane transporter activity	SLC25A42 SLC25A25 ABCD1	4.51e-04	26	116	3	GO:0000295
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	GDPD5 PLCL1 PLCG1	4.51e-04	26	116	3	GO:0004435
GeneOntologyMolecularFunction	adenosine 3',5'-bisphosphate transmembrane transporter activity	SLC25A42 ABCD1	4.94e-04	6	116	2	GO:0071077
GeneOntologyMolecularFunction	nuclear localization sequence binding	RANBP6 KPNA6 IPO4	5.05e-04	27	116	3	GO:0008139
GeneOntologyMolecularFunction	purine nucleotide transmembrane transporter activity	SLC25A42 SLC25A25 ABCD1	6.25e-04	29	116	3	GO:0015216
GeneOntologyMolecularFunction	phospholipase C activity	GDPD5 PLCL1 PLCG1	6.25e-04	29	116	3	GO:0004629
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	RANBP6 KPNA6 IPO4	8.38e-04	32	116	3	GO:0140142
GeneOntologyMolecularFunction	nucleotide transmembrane transporter activity	SLC25A42 SLC25A25 ABCD1	9.18e-04	33	116	3	GO:0015215
GeneOntologyBiologicalProcess	neuron development	FAT4 RPGRIP1L ZFYVE27 KALRN FAT3 ETV4 APOA4 PLXND1 PARP6 CDKL5 PTK2B GDPD5 AP2A1 GLI2 HPRT1 UGDH PRICKLE2 RAPGEF2 SEPTIN7 SCLT1 PALLD TOP2B	1.68e-05	1463	115	22	GO:0048666
Domain	PH_dom-like	CNKSR1 FGD2 KALRN MYO7B SHC3 PTK2B PHLDB1 PLCL1 PLCG1 ARHGEF2 AGAP1	4.67e-05	426	111	11	IPR011993
Domain	-	CNKSR1 FGD2 KALRN MYO7B SHC3 PHLDB1 PLCL1 PLCG1 ARHGEF2 AGAP1	1.14e-04	391	111	10	2.30.29.30
Domain	Graves_DC	SLC25A42 SLC25A25	2.08e-04	4	111	2	IPR002167
Domain	PH	CNKSR1 FGD2 KALRN PHLDB1 PLCL1 PLCG1 ARHGEF2 AGAP1	2.56e-04	278	111	8	SM00233
Domain	PH_DOMAIN	CNKSR1 FGD2 KALRN PHLDB1 PLCL1 PLCG1 ARHGEF2 AGAP1	2.62e-04	279	111	8	PS50003
Domain	PH_domain	CNKSR1 FGD2 KALRN PHLDB1 PLCL1 PLCG1 ARHGEF2 AGAP1	2.69e-04	280	111	8	IPR001849
Domain	Anaphylatoxin_comp_syst	C4A C4B	3.46e-04	5	111	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	3.46e-04	5	111	2	IPR001840
Domain	IPT_NFkappaB	REL NFKB2	3.46e-04	5	111	2	IPR033926
Domain	RHD_CS	REL NFKB2	3.46e-04	5	111	2	IPR030492
Domain	-	RANBP6 KPNA6 IPO4 ATAD2 AP2A1 ASPM RIPOR1	3.64e-04	222	111	7	1.25.10.10
Domain	-	GDPD5 PLCL1 PLCG1	4.27e-04	25	111	3	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	GDPD5 PLCL1 PLCG1	4.27e-04	25	111	3	IPR017946
Domain	PH	CNKSR1 FGD2 KALRN PHLDB1 PLCG1 ARHGEF2 AGAP1	4.38e-04	229	111	7	PF00169
Domain	IPT	REL PLXND1 NFKB2	5.39e-04	27	111	3	SM00429
Domain	ANATO	C4A C4B	7.21e-04	7	111	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	7.21e-04	7	111	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	7.21e-04	7	111	2	PS01177
Domain	ANATO	C4A C4B	7.21e-04	7	111	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	7.21e-04	7	111	2	IPR000020
Domain	IPT	REL PLXND1 NFKB2	8.94e-04	32	111	3	IPR002909
Domain	ARM-type_fold	RANBP6 KPNA6 APOB IPO4 URB1 AP2A1 ASPM RIPOR1	9.47e-04	339	111	8	IPR016024
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	9.57e-04	8	111	2	IPR019565
Domain	Thiol-ester_cl	C4A C4B	9.57e-04	8	111	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	9.57e-04	8	111	2	IPR019742
Domain	cNMP	KCNH4 PRKG2 RAPGEF2	1.07e-03	34	111	3	SM00100
Domain	EF-hand_8	LPCAT1 CAPN3 SLC25A25	1.07e-03	34	111	3	PF13833
Domain	cNMP_binding	KCNH4 PRKG2 RAPGEF2	1.07e-03	34	111	3	PF00027
Domain	ARM-like	RANBP6 KPNA6 IPO4 ATAD2 AP2A1 ASPM RIPOR1	1.15e-03	270	111	7	IPR011989
Domain	cNMP-bd_dom	KCNH4 PRKG2 RAPGEF2	1.16e-03	35	111	3	IPR000595
Domain	CNMP_BINDING_3	KCNH4 PRKG2 RAPGEF2	1.16e-03	35	111	3	PS50042
Domain	cNMP-bd-like	KCNH4 PRKG2 RAPGEF2	1.48e-03	38	111	3	IPR018490
Domain	RHD_dimer	REL NFKB2	1.53e-03	10	111	2	IPR032397
Domain	RHD_dimer	REL NFKB2	1.53e-03	10	111	2	PF16179
Domain	REL_1	REL NFKB2	1.53e-03	10	111	2	PS01204
Domain	A2M	C4A C4B	1.53e-03	10	111	2	PF00207
Domain	A2M_N_2	C4A C4B	1.53e-03	10	111	2	IPR011625
Domain	A2M_comp	C4A C4B	1.53e-03	10	111	2	IPR011626
Domain	A2M_recep	C4A C4B	1.53e-03	10	111	2	PF07677
Domain	A2M_comp	C4A C4B	1.53e-03	10	111	2	PF07678
Domain	-	REL NFKB2	1.53e-03	10	111	2	2.60.40.340
Domain	A2M_N	C4A C4B	1.53e-03	10	111	2	PF01835
Domain	A2M_N	C4A C4B	1.53e-03	10	111	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.53e-03	10	111	2	IPR009048
Domain	NFkB/Dor	REL NFKB2	1.53e-03	10	111	2	IPR000451
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.53e-03	10	111	2	PS00477
Domain	RHD_DNA_bind_dom	REL NFKB2	1.53e-03	10	111	2	IPR011539
Domain	RHD_DNA_bind	REL NFKB2	1.53e-03	10	111	2	PF00554
Domain	A2M_N_2	C4A C4B	1.53e-03	10	111	2	PF07703
Domain	REL_2	REL NFKB2	1.53e-03	10	111	2	PS50254
Domain	Macroglobln_a2	C4A C4B	1.53e-03	10	111	2	IPR001599
Domain	-	KCNH4 PRKG2 RAPGEF2	2.91e-03	48	111	3	2.60.120.10
Domain	SH2	SHC3 SHE PLCG1 SH2D7	3.10e-03	101	111	4	PF00017
Domain	RmlC-like_jellyroll	KCNH4 PRKG2 RAPGEF2	3.46e-03	51	111	3	IPR014710
Domain	EF-hand_like	PLCL1 PLCG1	3.49e-03	15	111	2	PF09279
Domain	PI-PLC-Y	PLCL1 PLCG1	3.49e-03	15	111	2	PF00387
Domain	PLCYc	PLCL1 PLCG1	3.49e-03	15	111	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCL1 PLCG1	3.49e-03	15	111	2	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCL1 PLCG1	3.49e-03	15	111	2	PS50008
Domain	PI-PLC_fam	PLCL1 PLCG1	3.49e-03	15	111	2	IPR001192
Domain	PLC_EF-hand-like	PLCL1 PLCG1	3.49e-03	15	111	2	IPR015359
Domain	SH2	SHC3 SHE PLCG1 SH2D7	4.21e-03	110	111	4	SM00252
Domain	SH2	SHC3 SHE PLCG1 SH2D7	4.35e-03	111	111	4	PS50001
Domain	SH2	SHC3 SHE PLCG1 SH2D7	4.49e-03	112	111	4	IPR000980
Domain	-	SHC3 SHE PLCG1 SH2D7	4.49e-03	112	111	4	3.30.505.10
Domain	C345C	C4A C4B	4.49e-03	17	111	2	SM00643
Domain	VWA	VWF ITGAX CLCA2	4.50e-03	56	111	3	PF00092
Domain	-	LPCAT1 SPTA1 CAPN3 SLC25A25 PLCL1 PLCG1	4.69e-03	261	111	6	1.10.238.10
Domain	PI-PLC-X	PLCL1 PLCG1	5.03e-03	18	111	2	PF00388
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	5.03e-03	18	111	2	IPR008930
Domain	HATPase_c	MORC4 TOP2B	5.03e-03	18	111	2	SM00387
Domain	PLCXc	PLCL1 PLCG1	5.03e-03	18	111	2	SM00148
Domain	NTR	C4A C4B	5.60e-03	19	111	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	5.60e-03	19	111	2	IPR018933
Domain	HATPase_c	MORC4 TOP2B	5.60e-03	19	111	2	PF02518
Domain	PIPLC_X_DOMAIN	PLCL1 PLCG1	5.60e-03	19	111	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCL1 PLCG1	5.60e-03	19	111	2	IPR000909
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	FOXO3 CNKSR1 ERBB4 VWF KALRN SPTA1 ETV4 SHC3 PRKG2 RAPGEF2 SEPTIN7	7.18e-06	327	90	11	M27565
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	FOXO3 CNKSR1 ERBB4 VWF KALRN SPTA1 ETV4 SHC3 RAPGEF2 SEPTIN7	3.43e-05	318	90	10	MM15278
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FOXO3 EHBP1 REL XPA TBL1XR1 AXIN1 CRY2 SRRT SETDB1 PHLDB1 AP2A1 NFKB2 RIPOR1 RAPGEF2 SEPTIN7 AGAP1	3.76e-07	1038	116	16	26673895
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	VWF KALRN SPTA1 CDKL5 PTK2B SRRT PHLDB1 AP2A1 SVIL PRICKLE2 C4A C4B PLCL1 ARHGEF2 RAPGEF2 SEPTIN7 CROCC	5.48e-06	1431	116	17	37142655
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.10e-05	2	116	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.10e-05	2	116	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.10e-05	2	116	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.10e-05	2	116	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.10e-05	2	116	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.10e-05	2	116	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.10e-05	2	116	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.10e-05	2	116	2	12207352
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.10e-05	2	116	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.10e-05	2	116	2	22387014
Pubmed	The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.	KALRN HPRT1	1.10e-05	2	116	2	24380811
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.10e-05	2	116	2	23749435
Pubmed	Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.	A1CF APOB	1.10e-05	2	116	2	16055734
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.10e-05	2	116	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.10e-05	2	116	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.10e-05	2	116	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.10e-05	2	116	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.10e-05	2	116	2	6950384
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.10e-05	2	116	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.10e-05	2	116	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.10e-05	2	116	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.10e-05	2	116	2	21345967
Pubmed	Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase.	ACSBG1 ABCD1	1.10e-05	2	116	2	14516277
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.10e-05	2	116	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.10e-05	2	116	2	2302180
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.10e-05	2	116	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.10e-05	2	116	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.10e-05	2	116	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.10e-05	2	116	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.10e-05	2	116	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.10e-05	2	116	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.10e-05	2	116	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.10e-05	2	116	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.10e-05	2	116	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.10e-05	2	116	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.10e-05	2	116	2	2387317
Pubmed	Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis.	LPCAT1 PLA2G4A	1.10e-05	2	116	2	18802104
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.10e-05	2	116	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.10e-05	2	116	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.10e-05	2	116	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.10e-05	2	116	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.10e-05	2	116	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.10e-05	2	116	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.10e-05	2	116	2	6881182
Pubmed	Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa.	PDE6B GNAT3	1.10e-05	2	116	2	22952865
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.10e-05	2	116	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.10e-05	2	116	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.10e-05	2	116	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.10e-05	2	116	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.10e-05	2	116	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.10e-05	2	116	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	1.10e-05	2	116	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.10e-05	2	116	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.10e-05	2	116	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.10e-05	2	116	2	32691186
Pubmed	apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB.	APOA4 APOB	1.10e-05	2	116	2	15258202
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.10e-05	2	116	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.10e-05	2	116	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.10e-05	2	116	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.10e-05	2	116	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.10e-05	2	116	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.10e-05	2	116	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.10e-05	2	116	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.10e-05	2	116	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.10e-05	2	116	2	6559257
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.10e-05	2	116	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.10e-05	2	116	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.10e-05	2	116	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.10e-05	2	116	2	26800705
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.10e-05	2	116	2	15390104
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.10e-05	2	116	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.10e-05	2	116	2	2997024
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.10e-05	2	116	2	3624865
Pubmed	Identification of the molecular basis of doxorubicin-induced cardiotoxicity.	A1CF TOP2B	1.10e-05	2	116	2	23104132
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.10e-05	2	116	2	21857912
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.10e-05	2	116	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.10e-05	2	116	2	4514997
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.10e-05	2	116	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.10e-05	2	116	2	3167981
Pubmed	Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium.	VWF HPRT1	1.10e-05	2	116	2	23529929
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.10e-05	2	116	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.10e-05	2	116	2	30041577
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.10e-05	2	116	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.10e-05	2	116	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.10e-05	2	116	2	18360261
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.10e-05	2	116	2	26814963
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.10e-05	2	116	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	1.10e-05	2	116	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	1.10e-05	2	116	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	1.10e-05	2	116	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	1.10e-05	2	116	2	6167582
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	1.10e-05	2	116	2	1438267
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	1.10e-05	2	116	2	19150565
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	1.10e-05	2	116	2	17506029
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	1.10e-05	2	116	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	1.10e-05	2	116	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	1.10e-05	2	116	2	2993295
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	1.10e-05	2	116	2	3944109
Interaction	FLT1 interactions	SRPRA APOB IPO4 PTK2B URB1 SVIL PLCG1 ARHGEF2	8.18e-06	179	114	8	int:FLT1
Interaction	CHN2 interactions	PDE6B GLI2 PRICKLE2 PLCL1 ARHGEF2 RAPGEF2	1.87e-05	97	114	6	int:CHN2
Interaction	PDLIM5 interactions	DCAF15 PDE6B CEP128 GLI2 PRICKLE2 NUCKS1 UBR3 ARHGEF2 RAPGEF2	2.53e-05	273	114	9	int:PDLIM5
Interaction	DAB2IP interactions	CUL4A KALRN CDKL5 PRICKLE2 ARHGEF2 RAPGEF2	2.63e-05	103	114	6	int:DAB2IP
Interaction	GRIN1 interactions	SPTA1 SHC3 BDKRB1 CDKL5 PTK2B PLA2G4A PLCG1	2.76e-05	154	114	7	int:GRIN1
Interaction	GRIN2B interactions	KALRN SPTA1 SHC3 CDKL5 PTK2B PLA2G4A PLCG1	5.18e-05	170	114	7	int:GRIN2B
Interaction	GIT1 interactions	KALRN PTK2B SRRT NUCKS1 PLCG1 CROCC PMF1	5.58e-05	172	114	7	int:GIT1
Interaction	CC2D1B interactions	FAT4 FAT3 SRRT NUCKS1	6.18e-05	38	114	4	int:CC2D1B
Interaction	SYNGAP1 interactions	KALRN PDE6B CDKL5 PTK2B PRICKLE2 PLCL1 ARHGEF2 RAPGEF2 AGAP1	6.29e-05	307	114	9	int:SYNGAP1
Interaction	SORBS1 interactions	DCAF15 KALRN CEP128 CDKL5 PRICKLE2 ARHGEF2	7.12e-05	123	114	6	int:SORBS1
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4A PLCL1 PLCG1	8.27e-05	19	82	3	832
GeneFamily	Ankyrin repeat domain containing\|NF-kappa B complex subunits	REL NFKB2	2.01e-04	5	82	2	1254
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CNKSR1 FGD2 PHLDB1 PLCG1 ARHGEF2 AGAP1	3.47e-04	206	82	6	682
GeneFamily	Complement system\|Sushi domain containing	ITGAX C4A C4B	5.76e-04	36	82	3	492
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	7.17e-04	9	82	2	1234
GeneFamily	SH2 domain containing	SHC3 SHE PLCG1 SH2D7	1.15e-03	101	82	4	741
GeneFamily	Cadherin related	FAT4 FAT3	2.64e-03	17	82	2	24
GeneFamily	Armadillo repeat containing\|Importins	KPNA6 IPO4	2.97e-03	18	82	2	596
GeneFamily	EF-hand domain containing	LPCAT1 SPTA1 CAPN3 SLC25A25 PLCG1	3.19e-03	219	82	5	863
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FGD2 KALRN ARHGEF2	3.35e-03	66	82	3	722
GeneFamily	Apolipoproteins	APOA4 APOB	4.03e-03	21	82	2	405
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	CMTR1 GPATCH3	4.43e-03	22	82	2	579
GeneFamily	ETS transcription factor family	ETV4 SPDEF	7.12e-03	28	82	2	534
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE27 FGD2	8.68e-03	31	82	2	81
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 FAT4 KALRN MYO7B FAT3 SPTA1 APOB	5.79e-07	184	117	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 FAT4 KALRN MYO7B FAT3 SPTA1 APOB	5.79e-07	184	117	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 FAT4 KALRN MYO7B FAT3 SPTA1 APOB	5.79e-07	184	117	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Adult / Lineage, Cell type, age group and donor	LPCAT1 ERBB4 SHC3 TOX3 PRICKLE2 PLCL1 AGAP1	6.01e-07	185	117	7	673f0c688ae6984bc8027df2da335787924f4137
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT4 VWF TBC1D20 TOX3 PRICKLE2 SHE RIPOR1	7.19e-07	190	117	7	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF APOA4 PLXND1 ATAD2 CEP128 ASPM	7.42e-07	119	117	6	c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ABCC9 SHC3 GLI2 PRICKLE2 PLA2G4A PALLD	7.44e-07	191	117	7	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ABCC9 SHC3 GLI2 PRICKLE2 PLA2G4A PALLD	7.44e-07	191	117	7	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LPCAT1 ERBB4 SHC3 CDKL5 PLCL1 PRKG2 ARHGEF2	7.71e-07	192	117	7	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A42 FAT3 SPTA1 GPATCH3 C4B SH2D7	5.89e-06	170	117	6	b180ec9a1b79025a180c8559c27c31272410dea8
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A42 FAT3 SPTA1 GPATCH3 C4B SH2D7	5.89e-06	170	117	6	37c647f67505aa1ff12a198df1eeddd9f406fe15
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB4 SHC3 TOX3 PRICKLE2 PLCL1 AGAP1	7.66e-06	178	117	6	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB4 SHC3 TOX3 PRICKLE2 PLCL1 AGAP1	9.55e-06	185	117	6	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|World / Lineage, Cell type, age group and donor	LPCAT1 ERBB4 SHC3 TOX3 PLCL1 AGAP1	1.01e-05	187	117	6	81cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.08e-05	189	117	6	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 FAT4 KALRN ABCC9 URB1 GLI2	1.11e-05	190	117	6	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 MYZAP GDPD5 UBR3 SHE	1.11e-05	190	117	6	32400c62cb9de4c2b24af4206c21a0215ab12212
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 FAT4 KALRN ABCC9 URB1 GLI2	1.11e-05	190	117	6	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.11e-05	190	117	6	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 MYZAP GDPD5 UBR3 SHE	1.11e-05	190	117	6	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.11e-05	190	117	6	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PRICKLE2 PLA2G4A PALLD	1.14e-05	191	117	6	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ERBB4 SVIL PRICKLE2 PLCL1 RAPGEF2 AGAP1	1.18e-05	192	117	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT4 VWF TBC1D20 TOX3 PRICKLE2 RIPOR1	1.21e-05	193	117	6	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAT4 VWF TBC1D20 TOX3 PRICKLE2 RIPOR1	1.21e-05	193	117	6	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FGD2 MYO7B REL PTK2B RIPOR1 SYVN1	1.25e-05	194	117	6	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 VWF WNT2B PHLDB1 PRICKLE2 SHE	1.25e-05	194	117	6	40842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FAT4 KALRN FAT3 TBL1XR1 GLI2 PRICKLE2	1.29e-05	195	117	6	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.33e-05	196	117	6	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAT4 ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.33e-05	196	117	6	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	VWF KALRN ABCC9 PLXND1 MYZAP SHE	1.36e-05	197	117	6	4e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_3\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	A1CF CCDC168 KCNH4 PARP6 GDPD5	3.93e-05	144	117	5	ce5e219f2548b51440b8b3e1a9f011afd4510d19
ToppCell	COVID-19_Moderate-multiplets\|COVID-19_Moderate / disease group, cell group and cell class	GDPD5 PPY PLCG1 SH2D7 AGAP1	4.34e-05	147	117	5	baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB4 IL22RA2 SVIL GNAT3 SH2D7	5.25e-05	153	117	5	3b1b0cc8e9dd2b1484649789330713282ee44414
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LPCAT1 ERBB4 PLCL1 PRKG2 AGAP1	6.30e-05	159	117	5	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	TCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-7\|TCGA-Stomach / Sample_Type by Project: Shred V9	KIAA0408 FAT3 ADHFE1 PLCL1 NMBR	6.89e-05	162	117	5	b115b5799137122bd60696f8ae2aebadad6cd044
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYZAP CLCA2 ASPM NUCKS1 SHE	7.09e-05	163	117	5	7864e966c228282b4b63c43164dba3faba21026d
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO7B FAT3 GNAT3 PLA2G4A SH2D7	7.51e-05	165	117	5	34fd00be2b28716c871ad9fb356de84a299a0c01
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR1 ERBB4 ETV4 BDKRB1 TOX3	7.95e-05	167	117	5	cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR1 ERBB4 ETV4 BDKRB1 TOX3	8.41e-05	169	117	5	30141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	VWF GCM2 PLXND1 UGDH PALLD	8.65e-05	170	117	5	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	ERBB4 SHC3 TOX3 PLCL1 AGAP1	8.65e-05	170	117	5	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB4 SHC3 PRICKLE2 PLCL1 AGAP1	8.65e-05	170	117	5	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 FAT4 GLI2 MEIOSIN PALLD	8.89e-05	171	117	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO3 FAT4 GLI2 MEIOSIN PALLD	8.89e-05	171	117	5	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT2B ABCC9 SHC3 PHC1 PLCL1	9.39e-05	173	117	5	d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KALRN FAT3 SVIL PLCL1 PALLD	9.39e-05	173	117	5	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT2B ABCC9 SHC3 PHC1 PLCL1	9.39e-05	173	117	5	3c852ffe22f4a5b632463086b08c669310684e80
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBL1XR1 CLCA2 GLI2 TOX3 DDX25	9.64e-05	174	117	5	42f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAT4 CAPN3 CCDC168 PMEL SHE	9.91e-05	175	117	5	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	droplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFYVE27 PLXND1 AXIN1 GDPD5 PLCL1	1.02e-04	176	117	5	24b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	LPCAT1 ERBB4 SHC3 TOX3 PLCL1	1.02e-04	176	117	5	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZFYVE27 PLXND1 AXIN1 GDPD5 PLCL1	1.05e-04	177	117	5	f360f7099570d248531897b96e0de282e58f59e9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.13e-04	180	117	5	280ff5c8f292be1b88120db5ff1788b750644856
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.13e-04	180	117	5	fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	MORC4 CEP128 PHC1 URB1 RAPGEF2	1.13e-04	180	117	5	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	cellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC25A42 PDE6B CEP128 ITGAX PTK2B	1.19e-04	182	117	5	8ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCell	3'_v3-GI_small-bowel-Myeloid_Dendritic\|GI_small-bowel / Manually curated celltypes from each tissue	FGD2 MYZAP ITGAX IL22RA2 PPY	1.22e-04	183	117	5	6109199cf25b28831193a5ed7925b5bf38c6eb43
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 MYZAP GDPD5 SHE	1.29e-04	185	117	5	fb84fcf7f51f53489bcb3962fa9cb483e48257ed
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 MYZAP GDPD5 SHE	1.32e-04	186	117	5	9d250d5ae7cf9129be05b41d70cb6c3a046c5f1e
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	VWF KALRN PLXND1 SHE PLCG1	1.32e-04	186	117	5	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	VWF PLXND1 GDPD5 SHE UPP2	1.35e-04	187	117	5	a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPCAT1 ETV4 TOX3 UGDH PRKG2	1.39e-04	188	117	5	7471c194276161422326647f09022e94f3d1640c
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	KALRN WNT2B MYZAP PHLDB1 PRICKLE2	1.39e-04	188	117	5	fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPCAT1 ETV4 TOX3 UGDH PRKG2	1.39e-04	188	117	5	053c251d3ddbeb866f34565aefca4535517b4387
ToppCell	343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|343B / Donor, Lineage, Cell class and subclass (all cells)	KALRN WNT2B MYZAP PHLDB1 PRICKLE2	1.39e-04	188	117	5	cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ETV4 ABCC9 PLCL1 RAPGEF2 SEPTIN7	1.42e-04	189	117	5	26cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA0408 FAT3 GLI2 PLCL1 PALLD	1.42e-04	189	117	5	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.46e-04	190	117	5	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN FAT3 ABCC9 GLI2 PALLD	1.46e-04	190	117	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.46e-04	190	117	5	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.49e-04	191	117	5	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCC9 GLI2 PLA2G4A PALLD	1.49e-04	191	117	5	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	FGD2 REL ITGAX PTK2B PLCL1	1.49e-04	191	117	5	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA0408 FAT3 GLI2 PLCL1 PALLD	1.49e-04	191	117	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB4 TOX3 PRICKLE2 PLCL1 AGAP1	1.49e-04	191	117	5	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN FAT3 ABCC9 GLI2 PALLD	1.49e-04	191	117	5	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LPCAT1 ERBB4 SHC3 PRKG2 ARHGEF2	1.49e-04	191	117	5	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	LPCAT1 ERBB4 SHC3 PRKG2 ARHGEF2	1.49e-04	191	117	5	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FAT4 VWF MYZAP PRICKLE2 SHE	1.49e-04	191	117	5	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN FAT3 ABCC9 GLI2 PALLD	1.49e-04	191	117	5	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCC9 GLI2 PLA2G4A PALLD	1.49e-04	191	117	5	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.53e-04	192	117	5	4022f208eb5db760abd0aac782a25e8ab63efc64
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.53e-04	192	117	5	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCC9 GLI2 PLA2G4A PALLD	1.53e-04	192	117	5	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 MYZAP GDPD5 SHE	1.53e-04	192	117	5	fa0ef05a32c661bdd59b5a9b6f75fd647ee937f3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC9 SHC3 GLI2 PLA2G4A PALLD	1.53e-04	192	117	5	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PLXND1 MYZAP GDPD5 SHE	1.53e-04	192	117	5	4e63d95f75fe6eb3f817e84528883e95093c5bbd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCC9 GLI2 PLA2G4A PALLD	1.53e-04	192	117	5	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GCM2 SPTA1 KCNH4 SPDEF SH2D7	1.57e-04	193	117	5	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CNKSR1 SRPRA CEP128 ASPM SYVN1	1.57e-04	193	117	5	227d82059a9f99937e0188ff57f2d0e485ebfe69
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CNKSR1 SRPRA CEP128 ASPM SYVN1	1.57e-04	193	117	5	38bb14df7f05c29565a1c7f175fafe636e543bf8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCC9 GLI2 PLA2G4A PALLD	1.57e-04	193	117	5	c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ABCC9 PLXND1 PPY SHE	1.57e-04	193	117	5	8be24713f8ba2545b7647d1994e9e993623ddaa3
ToppCell	droplet-Bladder-nan-3m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ABCC9 PLXND1 PPY SHE	1.57e-04	193	117	5	19dfc4a2c91fcea4f5991e7c44df46faeecb06b8
ToppCell	droplet-Bladder-nan-3m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ABCC9 PLXND1 PPY SHE	1.57e-04	193	117	5	351e0acd411a9eb0dbc0e358d0d1e3759753fa40
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CNKSR1 SRPRA CEP128 ASPM SYVN1	1.57e-04	193	117	5	3ba6d44248690b80f4caf791d463e60f1ab816c4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KALRN ABCC9 GLI2 PLA2G4A PALLD	1.57e-04	193	117	5	5b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CNKSR1 SRPRA CEP128 ASPM SYVN1	1.57e-04	193	117	5	ce3873ece35fd2155ea235cb3c8bcd235cc0ebde
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CNKSR1 SRPRA CEP128 ASPM SYVN1	1.57e-04	193	117	5	8f57b0473a2c2c07f83e5fe70f16862b1bb3b514
Drug	Lactobionic acid [96-82-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	A1CF CAPN3 REL NCAPH2 PHLDB1 CLCA2 PRKG2 ARHGEF2 SEPTIN7	7.77e-07	197	116	9	6605_UP
Drug	AG213	ERBB4 PTK2B ADHFE1 C4A PLCG1 TOP2B	6.32e-06	89	116	6	CID005328803
Drug	Etofenamate [30544-47-9]; Down 200; 10.8uM; HL60; HT_HG-U133A	CYP1A2 DCAF15 MRM1 CAPN3 SRRT SETDB1 GPATCH3 PALLD	7.51e-06	196	116	8	2907_DN
Drug	sodium linoleate	CYP1A2 FAT4 LPCAT1 ERBB4 APOA4 APOB ITGAX ACSBG1 NFKB2 PLA2G4A	1.02e-05	342	116	10	CID000003931
Disease	Malignant neoplasm of skin	ERBB4 XPA PTK2B GLI2	8.45e-05	59	115	4	C0007114
Disease	Skin Neoplasms	ERBB4 XPA PTK2B GLI2	8.45e-05	59	115	4	C0037286
Disease	diabetic angiopathy (implicated_via_orthology)	BDKRB1 PTK2B	2.24e-04	6	115	2	DOID:11713 (implicated_via_orthology)
Disease	familial combined hyperlipidemia (is_marker_for)	VWF APOB	2.24e-04	6	115	2	DOID:13809 (is_marker_for)
Disease	adrenoleukodystrophy (implicated_via_orthology)	ACSBG1 ABCD1	3.12e-04	7	115	2	DOID:10588 (implicated_via_orthology)
Disease	thalamus volume	FOXO3 FAT3 NUCKS1 AGAP1	3.48e-04	85	115	4	EFO_0006935
Disease	Atrial Fibrillation	CUL4A ERBB4 VWF ABCC9 NUCKS1	4.18e-04	160	115	5	C0004238
Disease	melanoma	FAT4 ERBB4 XPA PMEL PTK2B SETDB1	4.35e-04	248	115	6	C0025202
Disease	ciliopathy (implicated_via_orthology)	RPGRIP1L KIAA0753 SCLT1	5.13e-04	40	115	3	DOID:0060340 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	ERBB4 TBL1XR1 AXIN1 PRKG2	5.52e-04	96	115	4	C1319315
Disease	occupational attainment	ERBB4 PLCL1 AGAP1	5.93e-04	42	115	3	EFO_0020977
Disease	cardiovascular system disease (is_marker_for)	APOA4 APOB	6.64e-04	10	115	2	DOID:1287 (is_marker_for)
Disease	schizophrenia (is_marker_for)	VWF APOA4 SETDB1	6.80e-04	44	115	3	DOID:5419 (is_marker_for)
Disease	coffee consumption measurement	FOXO3 EHBP1 CYP1A2 APOA4 SETDB1	7.50e-04	182	115	5	EFO_0006781
Disease	Acute Promyelocytic Leukemia	TBL1XR1 ITGAX GLI2	7.75e-04	46	115	3	C0023487
Disease	visual epilepsy (is_implicated_in)	CDKL5 ASPM	8.09e-04	11	115	2	DOID:11832 (is_implicated_in)
Disease	Herpes Zoster, response to tofacitinib	VWF TOX3	9.69e-04	12	115	2	EFO_0006510, EFO_0600024
Disease	Hyperlipoproteinemia Type IIb	APOA4 APOB	1.14e-03	13	115	2	C1704417
Disease	sexual dimorphism measurement	FOXO3 APOA4 APOB FAM133B SETDB1 GPATCH3 GLI2 NUCKS1 SPDEF PRKG2 NMBR CROCC	1.29e-03	1106	115	12	EFO_0021796
Disease	Autosomal recessive primary microcephaly	PHC1 ASPM	1.53e-03	15	115	2	cv:C3711387
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	A1CF CAPN3 APOA4 APOB PLCG1	1.74e-03	220	115	5	EFO_0004529, EFO_0008317
Disease	Hyperlipoproteinemia Type IIa	APOA4 APOB	1.74e-03	16	115	2	C0745103
Disease	oral squamous cell carcinoma (is_marker_for)	ERBB4 AXIN1 PLCG1	1.93e-03	63	115	3	DOID:0050866 (is_marker_for)
Disease	Hypercholesterolemia, Familial	APOA4 APOB	2.21e-03	18	115	2	C0020445
Disease	Malignant neoplasm of liver	XPA TOX3 UGDH PRICKLE2	2.35e-03	142	115	4	C0345904
Disease	Liver neoplasms	XPA TOX3 UGDH PRICKLE2	2.35e-03	142	115	4	C0023903
Disease	coronary artery disease	EHBP1 CYP1A2 FAT4 ERBB4 APOA4 APOB RSBN1 GDPD5 PLCL1 PLCG1 RAPGEF2 PALLD	2.44e-03	1194	115	12	EFO_0001645
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB4 PLCG1	2.47e-03	19	115	2	DOID:2876 (is_marker_for)
Disease	glomerulonephritis (is_marker_for)	BDKRB1 PTK2B	2.47e-03	19	115	2	DOID:2921 (is_marker_for)
Disease	factor VIII measurement, Ischemic stroke	VWF PMF1	2.47e-03	19	115	2	EFO_0004630, HP_0002140
Disease	coagulation factor measurement	VWF ASPM	2.73e-03	20	115	2	EFO_0004634
Disease	Retinal Degeneration	RPGRIP1L PDE6B	3.01e-03	21	115	2	C0035304
Disease	lung cancer (is_implicated_in)	XRN2 AXIN1 SETDB1	3.06e-03	74	115	3	DOID:1324 (is_implicated_in)
Disease	Paroxysmal atrial fibrillation	CUL4A ERBB4 VWF NUCKS1	3.30e-03	156	115	4	C0235480
Disease	prostate cancer (is_marker_for)	FOXO3 ERBB4 PTK2B SETDB1	3.30e-03	156	115	4	DOID:10283 (is_marker_for)
Disease	familial atrial fibrillation	CUL4A ERBB4 VWF NUCKS1	3.30e-03	156	115	4	C3468561
Disease	Persistent atrial fibrillation	CUL4A ERBB4 VWF NUCKS1	3.30e-03	156	115	4	C2585653
Disease	Splenomegaly	CYP1A2 BDKRB1	3.31e-03	22	115	2	C0038002
Disease	Autosomal Recessive Primary Microcephaly	PHC1 ASPM	3.31e-03	22	115	2	C3711387
Disease	Primary microcephaly	PHC1 ASPM	3.31e-03	22	115	2	C0431350
Disease	Granulomatous Slack Skin	NFKB2 PLCG1	3.31e-03	22	115	2	C0376407
Disease	very low density lipoprotein cholesterol measurement	EHBP1 A1CF CAPN3 APOA4 APOB	3.57e-03	260	115	5	EFO_0008317
Disease	obsolete Mendelian syndromes with cleft lip/palate	MRM1 SVIL	3.61e-03	23	115	2	MONDO_0015335
Disease	Lymphoma, T-Cell, Cutaneous	NFKB2 PLCG1	3.61e-03	23	115	2	C0079773
Disease	hippocampal sclerosis of aging	MRM1 ABCC9	3.61e-03	23	115	2	EFO_0005678
Disease	epilepsy (implicated_via_orthology)	KALRN BDKRB1 KCNU1 PRICKLE2	3.86e-03	163	115	4	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RMARDPQRYLVIQGD	ERBB4	976	Q15303
YRVLVHPMASRRQQR	BDKRB1	136	P46663
TSRNLRQVDQMLGRY	CEP128	51	Q6ZU80
RMANYRNTSEIPLVL	AGAP1	161	Q9UPQ3
VRYRVFALDQKMRPS	C4B	156	P0C0L5
RAIIRAPSVREIYMN	A1CF	371	Q9NQ94
RLQEIYNRMDPRAQT	ARHGEF2	441	Q92974
SNRETIYPNASLLMR	CEACAM8	96	P31997
IYPNASLLMRNVTRN	CEACAM8	101	P31997
RRQYSLTVQAMDRGV	FAT4	316	Q6V0I7
EPNAQAQMYRLTLRT	AP2A1	946	O95782
NVIRVRRYVFFMNPQ	ABCC9	186	O60706
RQLRLLFDQAYQMRP	ATAD2	511	Q6PL18
DVQVMYAIRGNRIPR	DDX25	196	Q9UHL0
QRAAVLIQATFRMYR	ASPM	2481	Q8IZT6
YYSPRRVRDMQVAIA	C17orf113	171	A0A1B0GUU1
NRPAMNYDKLSRSLR	ETV4	386	P43268
SRMSQRYGDVLQIRI	CYP1A2	66	P05177
FRNLRPMLAADAQRY	ITGAX	746	P20702
RVPHFMQDLARYRQQ	KIAA0895L	436	Q68EN5
PRLRRDTQQGMYDAV	ACP7	151	Q6ZNF0
YRVSNMDGRLRNPDQ	ABCD1	181	P33897
EQLRRQLTPYAQRME	APOA4	151	P06727
MSRPVRNRKVVDYSQ	NUCKS1	1	Q9H1E3
SYKNNALNPEEMRRR	KPNA6	16	O60684
IYTLRNQDMQAAVRR	OR4D2	286	P58180
NPALYASNVRRVMAE	LPCAT1	286	Q8NF37
ALSADRYRAIVNPMD	NMBR	136	P28336
VNPRSAEDQRQLYAM	GNAT3	96	A8MTJ3
RVPMDQAIRLYRERA	RPGRIP1L	736	Q68CZ1
MARATLAQRSYLPQI	MYG1	361	Q9HB07
LAQAQRLIRMYSGRR	GPATCH3	111	Q96I76
AKRYRPQIMAALEAN	PLXND1	1881	Q9Y4D7
MYRQRNGVAELATRL	PDE6B	96	P35913
YQRKERSTAVMRSQP	KALRN	2241	O60229
VMAPYFLQQRDTLRR	PMF1	136	Q6P1K2
FGNVTAIIQRMYSRR	KCNH4	471	Q9UQ05
VRQMQGHLSPRSYRN	KIAA0408	521	Q6ZU52
QRMIRTSPNSLVAYI	GLI2	246	P10070
RSYNPEQIMLSAAVR	GDPD5	526	Q8WTR4
AEIYQPMLDRRSQRS	IL22RA2	241	Q969J5
LRNFVMPLRASNYTR	KCNU1	731	A8MYU2
MTQQERRPYCTKARR	MEIOSIN	581	C9JSJ3
MRRTAQARDEQYRNF	PRKG2	266	Q13237
ATPEQMAQYAADLRR	PPY	41	P01298
YIKALNRNSDRSIPM	HPRT1	81	P00492
NGQPRLTYEERMARR	PALLD	921	Q8WX93
PLRAREDYDQFMRQR	PRICKLE2	716	Q7Z3G6
NMARDQRSRATLYAL	APOB	431	P04114
RQLQVQDMRGRYEAS	CROCC	531	Q5TZA2
NRVAYMNPIAMARSR	FAM133B	6	Q5BKY9
ANYERPRMNANSLLA	CRY2	251	Q49AN0
ASRAPSKQRYVQEVM	AXIN1	721	O15169
SKQRYVQEVMRRGRA	AXIN1	726	O15169
VPDLAQMYQLFSRVR	CUL4A	316	Q13619
IMVRDQEFPYRRNLA	FAT3	1536	Q8TDW7
RRVNMNAAARPYHIQ	ACSBG1	666	Q96GR2
SQYIENRPEMKRQRS	EHBP1	1021	Q8NDI1
VLKISFRRNDPMERY	FGD2	326	Q7Z6J4
SILPNTRMYSRLNAE	CCDC168	1146	Q8NDH2
QMALGQRRNPYATLR	CFAP141	36	Q5VU69
QRRNPYATLRMQDTM	CFAP141	41	Q5VU69
MEQERNARYRTPKIL	PTK2B	691	Q14289
TYINMREVSQRFRLP	CAPN3	536	P20807
YNRTNRSRMPNLNDL	CDKL5	941	O76039
VVPSYMQAVNRERER	IPO4	751	Q8TEX9
NLRPMRERTAVQGQY	DCAF15	426	Q66K64
RARTRANPYEMIRGV	CMTR1	216	Q8N1G2
VRYRVFALDQKMRPS	C4A	156	P0C0L4
VQRYNRMNTIPQTRS	PARP6	536	Q2NL67
AMVESIEYRRQNPSR	PLA2G4A	711	P47712
MAAAARARVAYLLRQ	ADHFE1	1	Q8IWW8
APRRRAVSMDNSNKY	FOXO3	246	O43524
NQMRREGIRYARIQL	RSBN1	656	Q5VWQ0
RRAIRNMNTLYPDAT	SYVN1	266	Q86TM6
MPALVQRRIADYEAA	TIMM10B	71	Q9Y5J6
PASNRSMRSDRNTYV	UPP2	6	O95045
PNYDAREIVNNVRRM	TOP2B	886	Q02880
TRQRRMNARYQTQPV	SVIL	841	O95425
RPRRQKLDTMCRYQV	MRM1	101	Q6IN84
RRSAIKRQMASFYQP	GCM2	171	O75603
RRRLQNEMTTPSLDY	MORC4	576	Q8TE76
MLPRTKYNRFRNDSV	SHC3	1	Q92529
QSASYPLDVVRRRMQ	SLC25A42	241	Q86VD7
IRRQEQAARSARMLY	KIAA0753	256	Q2KHM9
YRRRLMKQDFSVPQL	PMEL	616	P40967
AVRNRRAGYEVRQMA	RANBP6	56	O60518
RAGYEVRQMAAALLR	RANBP6	61	O60518
RYRATVIQAFRDMNR	URB1	1951	O60287
AVMPDVVQTRQQAYR	TBL1XR1	86	Q9BZK7
TCLSRVRPMRNEQYR	SETDB1	581	Q15047
NRMVRGDPRAIVEYR	SRRT	851	Q9BXP5
RIYVAIRAMDRNSLQ	CLCA2	861	Q9UQC9
QQSAALPRRYMLRER	NCAPH2	286	Q6IBW4
SFMRRNRDPQLNERV	CNKSR1	606	Q969H4
YPLALVRTRMQAQAS	SLC25A25	396	Q6KCM7
PDYNVALQRSRMVAR	RAPGEF2	1426	Q9Y4G8
MNDYQRRRFASRIID	UGDH	306	O60701
RIYPSAMRIDSSNLN	PLCL1	641	Q15111
ASQEPQRMSRNFVRY	VWF	1386	P04275
YLNAESRVNRRQMPD	SEPTIN7	141	Q16181
NRPAMNYDKLSRSIR	SPDEF	296	O95238
SQVASNPRQAAYEMR	XRN2	451	Q9H0D6
LSQVNYRVPNMRFLR	PLCG1	181	P19174
IIYADLRRMNQARLG	SH2D7	241	A6NKC9
LRDIMDAQRRQRPYV	SRPRA	406	P08240
SSRPQIAQMSLYERQ	PHC1	21	P78364
EIIEQPRQRGMRFRY	REL	11	Q04864
RYEAIVRARNSMQLL	SCLT1	326	Q96NL6
RVMALYDFQARSPRE	SPTA1	981	P02549
TQVSQYRQDPSLIMR	TOX3	141	O15405
MREKQFSQARPLTRY	PHLDB1	1211	Q86UU1
LMLRQARLAARPYSA	XPA	36	P23025
RVVSEYRASLQQRMN	ZFYVE27	221	Q5T4F4
SNMRHFINYVRVRVP	UBR3	991	Q6ZT12
ASAQQRPDMVLRQRF	TBC1D20	331	Q96BZ9
PYDAQQMITEIRRRG	SHE	231	Q5VZ18
PSLREQAFYNMLRRQ	RIPOR1	356	Q6ZS17
RQRQLCQRYPDIMRS	WNT2B	81	Q93097
RSQPLARQYQAMRQR	MYO7B	821	Q6PIF6
QTGRTREIVMPSRNY	MYZAP	436	P0CAP1
APEMLQRAREYNARL	NFKB2	436	Q00653