Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L21 USP30 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

8.80e-1911410516GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L21 USP30 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.56e-1812410516GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L21 USP30 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

1.83e-1713710516GO:0019783
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L21 USP30 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

4.21e-1519210516GO:0008234
GeneOntologyMolecularFunctionpeptidase activity

USP17L21 USP30 USP17L23 USP17L12 TMPRSS13 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 ADAMTS12 ADAMTS7 USP17L17 USP17L6P LTF USP17L22 USP17L15 PCSK9 USP17L13

2.33e-1165410521GO:0008233
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRIK3 GRM2 GRM3

1.16e-0591053GO:0098988
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRIK3 GRM2 GRM3

1.16e-0591053GO:0001640
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

TET2 KDM5C KDM5D TET1 KDM6A

2.35e-05651055GO:0016706
GeneOntologyMolecularFunctiongroup II metabotropic glutamate receptor activity

GRM2 GRM3

2.74e-0521052GO:0001641
GeneOntologyMolecularFunction5-methylcytosine dioxygenase activity

TET2 TET1

8.19e-0531052GO:0070579
GeneOntologyMolecularFunctiondioxygenase activity

TET2 KDM5C KDM5D TET1 KDM6A

1.68e-04981055GO:0051213
GeneOntologyMolecularFunctioncytoskeletal anchor activity

ANK1 ANK3 OBSL1

2.64e-04241053GO:0008093
GeneOntologyMolecularFunctionglutamate receptor activity

GRIK3 GRM2 GRM3

3.77e-04271053GO:0008066
GeneOntologyMolecularFunctionmicrofibril binding

POLR2A LTBP1

4.05e-0461052GO:0050436
GeneOntologyMolecularFunctionhistone H3K4me/H3K4me2/H3K4me3 demethylase activity

KDM5C KDM5D

4.05e-0461052GO:0034647
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5C KDM5D KDM6A

4.21e-04281053GO:0141052
GeneOntologyMolecularFunctionhyaluronic acid binding

USP17L24 ACAN USP17L6P

4.67e-04291053GO:0005540
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5C KDM5D KDM6A

5.71e-04311053GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5C KDM5D KDM6A

6.27e-04321053GO:0140457
GeneOntologyMolecularFunctionhistone H3K4 demethylase activity

KDM5C KDM5D

7.51e-0481052GO:0032453
GeneOntologyMolecularFunctiondemethylase activity

KDM5C KDM5D KDM6A

1.60e-03441053GO:0032451
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

RNLS LOXL4

3.13e-03161052GO:0016641
GeneOntologyBiologicalProcessprotein deubiquitination

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

8.11e-1712510515GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

7.06e-1614410515GO:0070646
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

DCAF15 USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 UBR5 USP17L6P USP17L22 USP17L15 WDR24 USP17L13

3.15e-06100910518GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

DCAF15 USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 UBR5 USP17L6P USP17L22 USP17L15 WDR24 USP17L13

7.46e-06107410518GO:0043687
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

GRIK3 GRM2 GRM3

1.05e-0591053GO:0007196
GeneOntologyBiologicalProcesscollagen fibril organization

SELENON ADAMTS12 ADAMTS7 ACAN LOXL4

4.31e-05761055GO:0030199
GeneOntologyBiologicalProcessG protein-coupled glutamate receptor signaling pathway

GRIK3 GRM2 GRM3

6.84e-05161053GO:0007216
GeneOntologyCellularComponentpostsynaptic membrane

ANK1 ANK3 GRIK3 CLSTN2 GRM2 CSMD2 GRM3 SHISA9 CELSR3 FARP1 AFDN

8.08e-0640510811GO:0045211
GeneOntologyCellularComponentsynaptic membrane

ANK1 ANK3 GRIK3 CLSTN2 GRM2 CSMD2 GRM3 SHISA9 CELSR3 FARP1 AFDN HTT

4.83e-0558310812GO:0097060
GeneOntologyCellularComponentsomatodendritic compartment

FLNB PSD ANK3 ANKS1B GRIK3 CLSTN2 GRM2 GRM3 SHISA9 ACSL4 ACAN FARP1 LRP2 AFDN LTBP1 FUBP3 HTT CKMT1A

5.53e-05122810818GO:0036477
GeneOntologyCellularComponentpostsynaptic density

PSD ANK3 ANKS1B GRIK3 CLSTN2 CSMD2 GRM3 SHISA9 CELSR3 AFDN

1.16e-0445110810GO:0014069
GeneOntologyCellularComponentpostsynaptic density membrane

GRIK3 CLSTN2 CSMD2 SHISA9 CELSR3 AFDN

1.66e-041571086GO:0098839
GeneOntologyCellularComponentasymmetric synapse

PSD ANK3 ANKS1B GRIK3 CLSTN2 CSMD2 GRM3 SHISA9 CELSR3 AFDN

1.83e-0447710810GO:0032279
GeneOntologyCellularComponentpostsynaptic specialization

PSD ANK3 ANKS1B GRIK3 CLSTN2 CSMD2 GRM3 SHISA9 CELSR3 AFDN

2.80e-0450310810GO:0099572
GeneOntologyCellularComponentendoplasmic reticulum membrane

ATP8B3 USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 CLSTN2 USP17L19 SELENON USP17L18 ACSL4 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.32e-04129310817GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

ATP8B3 USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 CLSTN2 USP17L19 SELENON USP17L18 ACSL4 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.51e-04129910817GO:0098827
GeneOntologyCellularComponentneuron to neuron synapse

PSD ANK3 ANKS1B GRIK3 CLSTN2 CSMD2 GRM3 SHISA9 CELSR3 AFDN

3.81e-0452310810GO:0098984
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

ATP8B3 USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 CLSTN2 USP17L19 SELENON USP17L18 ACSL4 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

4.48e-04132710817GO:0042175
GeneOntologyCellularComponentdendrite

PSD ANK3 ANKS1B GRIK3 CLSTN2 GRM2 GRM3 SHISA9 FARP1 LRP2 LTBP1 FUBP3 HTT

4.82e-0485810813GO:0030425
GeneOntologyCellularComponentdendritic tree

PSD ANK3 ANKS1B GRIK3 CLSTN2 GRM2 GRM3 SHISA9 FARP1 LRP2 LTBP1 FUBP3 HTT

4.92e-0486010813GO:0097447
GeneOntologyCellularComponentpostsynaptic specialization membrane

GRIK3 CLSTN2 CSMD2 SHISA9 CELSR3 AFDN

6.22e-042011086GO:0099634
GeneOntologyCellularComponentpostsynapse

PSD ANK1 ANK3 ANKS1B GRIK3 CLSTN2 GRM2 CSMD2 GRM3 SHISA9 CELSR3 FARP1 AFDN HTT

7.55e-04101810814GO:0098794
GeneOntologyCellularComponentspectrin-associated cytoskeleton

ANK1 ANK3

9.30e-0491082GO:0014731
GeneOntologyCellularComponentglutamatergic synapse

ANKS1B GRIK3 CLSTN2 GRM2 CSMD2 GRM3 SHISA9 CELSR3 ACAN FARP1 CDH6 HTT

1.05e-0381710812GO:0098978
DomainHABP4_PAI-RBP1

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

2.82e-221610111PF04774
DomainHABP4_PAIRBP1-bd

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

2.82e-221610111IPR006861
DomainUSP_CS

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

2.46e-176610113IPR018200
DomainUSP_1

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

5.60e-177010113PS00972
DomainUCH

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

6.83e-177110113PF00443
DomainUSP_2

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

6.83e-177110113PS00973
DomainUSP_3

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

8.30e-177210113PS50235
DomainUSP_dom

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

8.30e-177210113IPR028889
DomainPeptidase_C19_UCH

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13

8.30e-177210113IPR001394
Domainzf-C2H2_6

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZNF699 ZNF841 ZNF282 ZFP2

7.78e-0631410110PF13912
DomainTet_JBP

TET2 TET1

2.90e-0521012PF12851
Domain2OGFeDO_noxygenase_dom

TET2 TET1

2.90e-0521012IPR024779
DomainTet_JBP

TET2 TET1

2.90e-0521012SM01333
DomainZnf_C2H2-like

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 TRAFD1 ZNF827 SF3A3 ZNF841 ZNF282 ZFP2

9.55e-0579610114IPR015880
DomainZnf_C2H2

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 TRAFD1 ZNF827 SF3A3 ZNF841 ZNF282 ZFP2

1.08e-0480510114IPR007087
DomainZnF_C2H2

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 TRAFD1 ZNF827 SF3A3 ZNF841 ZNF282 ZFP2

1.12e-0480810114SM00355
DomainLys_sp_deMease-like_dom

KDM5C KDM5D

1.73e-0441012IPR013637
DomainPLU-1

KDM5C KDM5D

1.73e-0441012PF08429
DomainJmjC

KDM5C KDM5D KDM6A

2.86e-04241013PF02373
Domainzf-C5HC2

KDM5C KDM5D

2.86e-0451012PF02928
DomainZnf_C5HC2

KDM5C KDM5D

2.86e-0451012IPR004198
Domain-

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 ZNF827 ZNF841 ZNF282 ZFP2

2.99e-04679101123.30.160.60
Domainzf-C2H2

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 ZNF827 ZNF841 ZNF282 ZFP2

3.60e-0469310112PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 ZNF827 ZNF841 ZNF282 ZFP2

3.65e-0469410112IPR013087
DomainJMJC

KDM5C KDM5D KDM6A

6.79e-04321013PS51184
DomainJmjC_dom

KDM5C KDM5D KDM6A

6.79e-04321013IPR003347
DomainJmjC

KDM5C KDM5D KDM6A

7.44e-04331013SM00558
DomainGPCR_3_mtglu_rcpt

GRM2 GRM3

7.94e-0481012IPR000162
DomainZINC_FINGER_C2H2_2

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 ZNF827 ZNF841 ZNF282 ZFP2

9.65e-0477510112PS50157
DomainZINC_FINGER_C2H2_1

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 ZNF827 ZNF841 ZNF282 ZFP2

9.87e-0477710112PS00028
DomainZU5

ANK1 ANK3

1.02e-0391012SM00218
DomainANF_lig-bd_rcpt

GRIK3 GRM2 GRM3

1.04e-03371013IPR001828
DomainANF_receptor

GRIK3 GRM2 GRM3

1.04e-03371013PF01094
DomainPeripla_BP_I

GRIK3 GRM2 GRM3

1.22e-03391013IPR028082
DomainJmjN

KDM5C KDM5D

1.27e-03101012SM00545
DomainJMJN

KDM5C KDM5D

1.27e-03101012PS51183
DomainZU5

ANK1 ANK3

1.27e-03101012PS51145
DomainAnk_3

ANK1 ANK3

1.27e-03101012PF13606
DomainJmjN

KDM5C KDM5D

1.27e-03101012PF02375
DomainJmjN

KDM5C KDM5D

1.27e-03101012IPR003349
DomainZU5

ANK1 ANK3

1.84e-03121012PF00791
DomainZU5_dom

ANK1 ANK3

1.84e-03121012IPR000906
DomainNCD3G

GRM2 GRM3

2.17e-03131012PF07562
DomainGPCR_3_9-Cys_dom

GRM2 GRM3

2.17e-03131012IPR011500
DomainGPCR_3_CS

GRM2 GRM3

2.53e-03141012IPR017979
Domain-

KDM5C KDM5D

2.90e-031510121.10.150.60
DomainBRIGHT

KDM5C KDM5D

2.90e-03151012SM00501
DomainARID_dom

KDM5C KDM5D

2.90e-03151012IPR001606
DomainARID

KDM5C KDM5D

2.90e-03151012PS51011
DomainARID

KDM5C KDM5D

2.90e-03151012PF01388
DomainPLAC

ADAMTS12 ADAMTS7

4.66e-03191012PS50900
DomainPLAC

ADAMTS12 ADAMTS7

4.66e-03191012IPR010909
PathwayREACTOME_RAS_PROCESSING

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

2.03e-19458213MM15671
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

4.28e-121918214MM15289
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L15 USP17L13

3.08e-112218214M27578
PathwayREACTOME_DEUBIQUITINATION

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

2.96e-102628214MM15286
PathwayREACTOME_DEUBIQUITINATION

USP17L21 USP30 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L15 USP17L13

1.66e-092998214M27574
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.38e-083188213MM15278
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L21 USP30 SP100 ANK1 USP17L12 ANK3 USP17L20 USP17L11 USP17L24 OBSL1 USP17L5 USP17L10 USP17L19 USP17L18 ADAMTS12 ADAMTS7 USP17L17 NCOA1 LTBP1 USP17L22 USP17L15 PCSK9 USP17L13

7.13e-0614758223M19806
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L21 USP30 SP100 ANK1 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 ADAMTS12 ADAMTS7 USP17L17 USP17L6P NCOA1 LTBP1 USP17L22 USP17L15 PCSK9 USP17L13

3.20e-0513898221MM15307
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5C KDM5D KDM6A

6.21e-0429823MM14934
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.03e-2821110138622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.03e-28211101314583620
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.03e-28211101311468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.03e-2821110138756639
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.03e-28211101312447969
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.03e-28211101318980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

7.38e-2822110139154835
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.30e-27331101420228807
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.69e-2724110138995226
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101420403174
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101417109758
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101420388806
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101414699124
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101420715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-2734110149806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101420368735
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101415780755
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101419188362
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101411941478
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101410936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

5.60e-27341101421448158
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

7.66e-27251101321115691
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

9.32e-27351101416611142
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

9.32e-27351101421239494
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

1.52e-26361101420147298
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

1.53e-26261101335816173
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

2.44e-26371101420228808
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

9.89e-26291101332527007
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

4.90e-22501101331806660
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

TET2 USP17L21 ANK1 USP17L12 USP17L20 USP17L11 GATA2 ZNF521 USP17L5 USP17L10 USP17L19 MAGEA13P USP17L18 USP17L17 USP17L6P USP17L22 KDM6A USP17L15 USP17L13

4.19e-136741101937196079
Pubmed

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.

USP17L21 USP17L12 USP17L20 USP17L11 USP17L19 USP17L18 USP17L17

1.09e-07119110728625976
Pubmed

X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis.

KDM5C KDM5D KDM6A

1.23e-074110332732223
Pubmed

PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.

TET2 TET1 KDM6A

3.06e-075110334667079
Pubmed

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

TET2 ACAN TET1

1.70e-068110328614801
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

SHLD2 FLNB ERCC4 ANK3 FLYWCH1 ZNF569 DHX38 ZNF429 ZNF699 FARP1 TET1 LRP2 MTO1 FUBP3 D2HGDH

1.71e-0610841101511544199
Pubmed

Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.

KDM5C KDM5D KDM6A

8.60e-0613110314660691
Pubmed

Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.

GRM2 GRM3

9.91e-062110223616537
Pubmed

Distributive Processing by the Iron(II)/α-Ketoglutarate-Dependent Catalytic Domains of the TET Enzymes Is Consistent with Epigenetic Roles for Oxidized 5-Methylcytosine Bases.

TET2 TET1

9.91e-062110227362828
Pubmed

Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.

GRM2 GRM3

9.91e-062110219638469
Pubmed

Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.

GRM2 GRM3

9.91e-062110221628565
Pubmed

Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.

GRM2 GRM3

9.91e-062110230939596
Pubmed

Structural insight into substrate preference for TET-mediated oxidation.

TET2 TET1

9.91e-062110226524525
Pubmed

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.

TET2 TET1

9.91e-062110230045709
Pubmed

Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.

TET2 TET1

9.91e-062110223415914
Pubmed

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.

GRM2 GRM3

9.91e-062110224053122
Pubmed

Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.

GRM2 GRM3

9.91e-062110238969501
Pubmed

The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.

KDM5C KDM6A

9.91e-062110237657612
Pubmed

Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.

GRM2 GRM3

9.91e-062110225583490
Pubmed

The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.

GRM2 GRM3

9.91e-062110223624743
Pubmed

Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice.

TET2 TET1

9.91e-062110230540950
Pubmed

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.

GRM2 GRM3

9.91e-062110217670976
Pubmed

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.

GRM2 GRM3

9.91e-062110225950516
Pubmed

The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.

GRM2 GRM3

9.91e-062110232525061
Pubmed

Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.

GRM2 GRM3

9.91e-062110219386277
Pubmed

Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.

GRM2 GRM3

9.91e-06211028838577
Pubmed

Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation.

TET2 TET1

9.91e-062110232114381
Pubmed

TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression.

TET2 GATA2

9.91e-062110237794021
Pubmed

Early Expression of Tet1 and Tet2 in Mouse Zygotes Altered DNA Methylation Status and Affected Embryonic Development.

TET2 TET1

9.91e-062110235955629
Pubmed

The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.

GRM2 GRM3

9.91e-06211027965099
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5C KDM5D

9.91e-062110210441747
Pubmed

Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.

GRM2 GRM3

9.91e-062110234330748
Pubmed

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

GRM2 GRM3

9.91e-062110225434487
Pubmed

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.

GRM2 GRM3

9.91e-062110228285415
Pubmed

Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.

GRM2 GRM3

9.91e-062110224080311
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5C KDM5D

9.91e-062110216416087
Pubmed

mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.

GRM2 GRM3

9.91e-062110234090896
Pubmed

Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.

TET2 TET1

9.91e-062110224214992
Pubmed

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.

TET2 TET1

9.91e-062110224474761
Pubmed

Ten-eleven translocation protein 1 modulates medulloblastoma progression.

TET2 TET1

9.91e-062110233926529
Pubmed

Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming.

TET2 TET1

9.91e-062110224672749
Pubmed

Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.

GRM2 GRM3

9.91e-062110222089319
Pubmed

A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands.

TET2 TET1

9.91e-062110227288448
Pubmed

Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination.

TET2 TET1

9.91e-062110230606231
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5C KDM5D

9.91e-062110232081420
Pubmed

The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.

ADAMTS12 ADAMTS7

9.91e-062110219098927
Pubmed

Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways.

TET2 TET1

9.91e-062110234165552
Pubmed

Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.

GRM2 GRM3

9.91e-062110221881873
Pubmed

Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation.

TET2 TET1

9.91e-062110226598602
Pubmed

Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.

GRM2 GRM3

9.91e-062110221832989
Pubmed

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.

TET2 TET1

9.91e-062110226586431
Pubmed

Identification of a recurrent transforming UBR5-ZNF423 fusion gene in EBV-associated nasopharyngeal carcinoma.

ZNF423 UBR5

9.91e-062110223878065
Pubmed

The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.

GRM2 GRM3

9.91e-062110225158312
Pubmed

Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns.

TET2 TET1

9.91e-062110235075236
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5C KDM5D

9.91e-06211029060413
Pubmed

Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells.

TET2 TET1

9.91e-062110226328763
Pubmed

Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells.

TET2 TET1

9.91e-062110227778125
Pubmed

Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking.

FGD4 LTBP1

9.91e-062110222295116
Pubmed

Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.

GRM2 GRM3

9.91e-062110227911756
Pubmed

Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.

GRM2 GRM3

9.91e-062110223392308
Pubmed

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.

GRM2 GRM3

9.91e-062110220970439
Pubmed

TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells.

TET2 TET1

9.91e-062110227863519
Pubmed

Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.

GRM2 GRM3

9.91e-062110218720515
Pubmed

Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome.

LRP2 PCSK9

9.91e-062110237406929
Pubmed

Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.

GRM2 GRM3

9.91e-062110234217776
Pubmed

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.

TET2 TET1

9.91e-062110228783731
Pubmed

Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells.

TET2 TET1

9.91e-062110228252217
Pubmed

Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein.

ZNF423 ZNF521

9.91e-062110212393497
Pubmed

Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.

GRM2 GRM3

9.91e-062110215246118
Pubmed

Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.

GRM2 GRM3

9.91e-062110218853337
Pubmed

Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.

GRM2 GRM3

9.91e-062110221057775
Cytoband4p16.1

USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

8.65e-2579110154p16.1
CytobandEnsembl 112 genes in cytogenetic band chr4p16

USP17L21 ZNF141 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 HTT USP17L13

6.02e-2122211017chr4p16
Cytoband16p13.12

ERCC4 SHISA9

2.53e-0410110216p13.12
Cytoband1p34.3

GRIK3 CSMD2 SF3A3

4.57e-046211031p34.3
Cytoband10q21

ANK3 TET1

6.68e-0416110210q21
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF141 ZBTB48 ZNF569 ZNF423 ZNF429 ZNF521 ZFPM1 ZNF699 ZNF827 ZNF841 ZNF282 ZFP2

2.09e-05718711228
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5C KDM5D KDM6A

1.11e-0424713485
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM2 GRM3

4.19e-048712281
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFHR2 CSMD2 ACAN

1.46e-03577131179
GeneFamilyAT-rich interaction domain containing

KDM5C KDM5D

1.54e-0315712418
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS12 ADAMTS7

2.49e-031971250
CoexpressionMADAN_DPPA4_TARGETS

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

2.47e-178610613MM1312
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

8.83e-1611210613MM1095
CoexpressionGERY_CEBP_TARGETS

USP17L21 USP17L12 ANK3 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

3.65e-1516010614MM1155
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP

USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 RIPK4 USP17L19 ZNF699 USP17L18 TRAFD1 ADAMTS7 USP17L17 USP17L6P NCOA1 HSD17B4 USP17L22 USP17L15 USP17L13

1.33e-1164710619MM981
CoexpressionBRUINS_UVC_RESPONSE_LATE

USP17L21 FLT1 USP17L12 USP17L20 USP17L11 USP17L5 ZCCHC17 USP17L10 USP17L19 USP17L18 SHISA9 ACSL4 CELSR3 USP17L17 FARP1 USP17L6P AFDN USP17L22 AJUBA KDM6A USP17L15 USP17L13 CKMT1A

3.64e-10119810623MM1062
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

USP17L21 SP100 USP17L12 USP17L20 USP17L11 POLR2A USP17L5 USP17L10 RIPK4 USP17L19 ZNF699 USP17L18 TRAFD1 ADAMTS7 USP17L17 USP17L6P NCOA1 HSD17B4 USP17L22 USP17L15 USP17L13

1.77e-08122610621MM979
CoexpressionMARSON_BOUND_BY_FOXP3_STIMULATED

USP17L21 USP17L12 USP17L20 USP17L11 KDM5C USP17L5 USP17L10 USP17L19 USP17L18 ACSL4 USP17L17 USP17L6P MTO1 USP17L22 KDM6A USP17L15 USP17L13

1.39e-06107210617MM1031
ToppCellPericytes-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FLNB ANK1 CLSTN2 ADAMTS12 ACAN LTBP1 CDH6

1.90e-07181101735c470988a93381eefa300831aabb813fa1b90bd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 ZNF827 FGD4 FARP1 LRP2 AFDN CDH6

3.04e-0719410177002937e8903e037332a215d00fbc7c7843b33f2
ToppCellNeuronal-Excitatory-eD(FEZF2)|Neuronal / cells hierarchy compared to all cells using T-Statistic

GPRIN3 GRIK3 CLSTN2 GRM3 ADAMTS12 AFDN CDH6

3.73e-0720010171b485ff2435c6732be58cbc9eb2f5c273f9c4bf2
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CHAD GRIK3 CSMD2 SHISA9 FGD4 CDH6

3.72e-061821016f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB FLT1 ZNF423 ZNF521 LTBP1 LTF

4.21e-06186101692092f11ecce22c14f244e42c499af0822977e6f
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 CHAD RIPK4 ZNF827 AJUBA CKMT1A

4.62e-061891016783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCellfacs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 CHAD RIPK4 ZNF827 AJUBA CKMT1A

4.62e-06189101688b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS13 CHAD RIPK4 ZNF827 AJUBA CKMT1A

4.76e-06190101647e07ea22733306d8885ee9e5f0b033e2f5e2afb
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS13 CHAD RIPK4 ZNF827 AJUBA CKMT1A

4.76e-061901016261b8afddfdcba4f70b50df126cef7ad00a0aae0
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TMPRSS13 RIPK4 SHISA9 FRY FGD4 LRP2

5.36e-0619410166b286992d4bb56013c0ea5a7601d3476d806175a
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHAD FRY ACAN FARP1 LOXL4 KLC3

5.86e-0619710166e111ba16fc8adde782b3f7da250248cddf11228
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 LTBP1 LTF

6.39e-062001016e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TET2 CD177 CFAP65 LTF CKMT1A

1.32e-051331015f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TET2 CD177 CFAP65 LTF CKMT1A

1.32e-051331015292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCellChildren_(3_yrs)-Immune-enucleated_erythrocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT1 NPIPB15 ANK1 ZNF423 SELENON

4.06e-0516810158f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANKS1B GRIK3 SHISA9 ACSL4 LTBP1

4.17e-0516910152456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ATP8B3 ZNF521 ADAMTS12 ADAMTS7 ZFP2

4.54e-051721015c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCellwk_20-22-Epithelial-PNS|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

GRIK3 CLSTN2 CSMD2 SHISA9 CDH6

4.66e-05173101517b1a6b0318925d5d920f2c0a791745b9587ebef
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANKS1B CHAD GRIK3 SHISA9 CDH6

4.79e-051741015412ccc099028a372b9d953363984c2da54b2187f
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP30 FLT1 FLYWCH1 GPRIN3 TOP3B

5.06e-05176101527e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHAD ACAN LOXL4 CDH6 KLC3

5.06e-05176101577c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCellfacs-Pancreas-Endocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 FLT1 CD177 GATA2 LTF

5.06e-0517610159ddf87e586d2378984cd007c60f7dc254845f8f3
ToppCellfacs-Pancreas-Endocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 FLT1 CD177 GATA2 LTF

5.06e-051761015e987e741fcf1bed8598a5060700efd3018f8123b
ToppCellfacs-Pancreas-Endocrine-18m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 FLT1 CD177 GATA2 LTF

5.06e-05176101592ebcea9b2b22601234b76d7a98f0410b905a87b
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CD177 HEATR5A GRIK3 SHISA9 CDH6

5.20e-05177101515a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK3 SHISA9 FGD4 LRP2 CDH6

5.20e-05177101559726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS13 RIPK4 LTF KLC3 CKMT1A

5.34e-051781015b89c4d015b44bf538aa39969ef8778877c8023f1
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMPRSS13 RIPK4 LTF KLC3 CKMT1A

5.34e-051781015fb8f8d95f6b08378fb42c4076ee040276faa296f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPRIN3 GRIK3 CLSTN2 LRRK1 ADAMTS12

5.48e-051791015c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPRIN3 GRIK3 CLSTN2 LRRK1 ADAMTS12

5.48e-05179101553e700494d251ec5649b2dea5fc7d5aeeeed572b
ToppCellfacs-Lung-nan-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN2 WFDC8 ADAMTS12 AJUBA CDH6

5.48e-0517910157078022e60faa86444f2a2c6eb9f767cc66b5cfa
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLSTN2 ADAMTS12 ACSL4 FRY FARP1

5.48e-051791015a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellfacs-Lung-nan-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLSTN2 WFDC8 ADAMTS12 AJUBA CDH6

5.48e-051791015d4a975d8ffa5e77fb5c0ec05bf9c8f843c77ce07
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPRIN3 CLSTN2 LRRK1 GRM3 ADAMTS12

5.63e-0518010158923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GRIK3 CSMD2 SHISA9 FGD4 CDH6

5.78e-051811015fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FLYWCH1 CD177 ZFPM1 ADAMTS7 LTF

5.93e-05182101552eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCellPCW_05-06-Neuronal-Neuronal_SCP|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK3 CSMD2 SHISA9 FGD4 CDH6

5.93e-051821015b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCelldroplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 GPRIN3 GRIK3 ADAMTS7 KLC3

5.93e-0518210156fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHISA9 FARP1 LRP2 LTF CDH6

6.09e-0518310156878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCellCOVID-19-kidney-Mito-rich_EC|kidney / Disease (COVID-19 only), tissue and cell type

SP100 FLT1 ZNF423 ZNF521 C1orf21

6.09e-0518310153c4153479fc4ab2d073d92cee120480015555914
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-hematologic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ANK1 GATA2 LTBP1 CDH6 KLC3

6.09e-0518310151db466cf757813322db1cdcc0bf1d91c062fd9de
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KDM5C SELENON ADAMTS12 FARP1 PCSK9

6.09e-05183101591079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 RIPK4 AJUBA KLC3 CKMT1A

6.09e-051831015ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CHAD GRIK3 SHISA9 FGD4 CDH6

6.09e-051831015f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLT1 GATA2 ZNF521 C1orf21 LTBP1

6.09e-051831015c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCellfacs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 RIPK4 AJUBA KLC3 CKMT1A

6.09e-051831015f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB FLT1 CD177 GATA2 AFDN

6.41e-051851015c3105978d971da7d0fad1a717ee29afee5ed6357
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB FLT1 CD177 GATA2 AFDN

6.41e-0518510154cfef50aeed5b3000ce5e864a41c13740b8267b1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANK1 GRIK3 WFDC8 ADAMTS12 ACAN

6.41e-051851015e87e6e097dc29ece8aea671935bde281b99b93ea
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GRIK3 CSMD2 SHISA9 FGD4 CDH6

6.41e-05185101556c7a0dbf141728ac76b8c90af197719942ca67c
ToppCellfacs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB FLT1 CD177 GATA2 AFDN

6.41e-05185101509256c6f42f59b7eb89160b2ea706172a5b743be
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK3 CSMD2 SHISA9 FGD4 CDH6

6.41e-051851015a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB FLT1 LRRK1 FGD4 LTBP1

6.57e-0518610152d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ANK3 ADAMTS12 MB21D2 C1orf21 CDH6

6.57e-051861015cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CLSTN2 MB21D2 FARP1 LRP2 CDH6

6.74e-0518710159d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANK3 DHX38 SHISA9 LRP2 NCOA1

6.74e-051871015f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 GPRIN3 FRY MB21D2 AFDN

6.91e-0518810153e3055dacc05a932f2beb114babf1dc76994e1af
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANK3 RIPK4 FRY FGD4 LRP2

7.09e-0518910157659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 AFDN LTBP1 LTF CKMT1A

7.09e-05189101527e5d706f10a6221f314faf642eede15deab3165
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CLSTN2 MB21D2 FARP1 LRP2 CDH6

7.27e-051901015989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

SP100 KDM5D ADAMTS12 NCOA1 AFDN

7.27e-05190101562a3ec1ae0829602b0569cc051210551644f1d46
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHAD GPRIN3 RIPK4 ACAN CKMT1A

7.45e-051911015116fba9badea093e11f370996247cca0e4c02e8f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CLSTN2 MB21D2 FARP1 LRP2 CDH6

7.45e-0519110151cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 ATXN7L1 FGD4 FARP1 LRP2

7.64e-051921015e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB FLT1 ZNF423 ZNF521 AFDN

7.82e-0519310156e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 FGD4 FARP1 LRP2 AFDN

7.82e-0519310153866667dd221612589ae50f5c52f73a183a49ce6
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 TMPRSS13 RIPK4 KLC3 CKMT1A

7.82e-05193101522ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCellfacs-Trachea-nan-3m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 CLSTN2 RIPK4 LRP2 CKMT1A

8.02e-0519410153701ca87c6dc9ccd7b4146e56371546174d26c36
ToppCellfacs-Trachea-nan-3m-Epithelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 CLSTN2 RIPK4 LRP2 CKMT1A

8.02e-05194101565f9bf126be26114c2c3f4c46d48318986212a92
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ZNF423 ANKS1B ZNF521 ADAMTS12 FARP1

8.02e-051941015b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 CLSTN2 LRP2 LOXL4 CDH6

8.02e-05194101570185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB FLT1 ZNF423 ZNF521 AFDN

8.02e-0519410150b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANK1 CD177 GPRIN3 GRIK3 FARP1

8.02e-0519410151bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RIPK4 SHISA9 FRY FGD4 LRP2

8.02e-051941015f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ZNF423 ANKS1B ZNF521 ADAMTS12 FARP1

8.21e-0519510150e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GRIK3 CSMD2 SHISA9 FGD4 CDH6

8.41e-0519610159afd0a7135028a446f06bb68f334e79b8f171b45
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHAD FRY ACAN FARP1 LOXL4

8.62e-0519710154b6c0e028b9669c102df8e9dc63e284f8d5fd9ee
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHAD FRY ACAN FARP1 LOXL4

8.62e-051971015ece0c17eb68f394b20e588c0b0626d3987a4dbbb
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

ANK3 UBR5 FGD4 NCOA1 KDM6A

9.04e-05199101594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLNB FLT1 ZNF521 UBR5 AFDN

9.25e-052001015dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Vein|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 FRY

9.25e-0520010157eb366b2c5394af7c77650bde6261e7dac67154e
ToppCellNeuronal-Excitatory-eG(DAPK2)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GPRIN3 CLSTN2 LRRK1 GRM3 ADAMTS12

9.25e-0520010157cea58e2691564e653cc972bf5aaff2df1f2666e
ToppCellNeuronal-Excitatory-eG(DAPK2)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

GPRIN3 CLSTN2 LRRK1 GRM3 ADAMTS12

9.25e-052001015193c42c31a366a60d80c4c1fc6a1592a5b01a3ad
ToppCellNeuronal-Excitatory-eG(DAPK2)---|Neuronal / cells hierarchy compared to all cells using T-Statistic

GPRIN3 CLSTN2 LRRK1 GRM3 ADAMTS12

9.25e-0520010157c780e995a5fc3793080da61b6bf7a12880e9df8
ToppCellNeuronal-Excitatory-eG(DAPK2)----L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

GPRIN3 CLSTN2 LRRK1 GRM3 ADAMTS12

9.25e-052001015d0b31dc5eedc0635c0d7ceabaa6202386cf2a4a4
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

HEATR5A RIPK4 ZNF827 FARP1 AFDN

9.25e-0520010152dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-052001015eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-05200101581e76508c9050d533853d5fd2f3097b27613d836
ToppCellNeuronal-Excitatory-eG(DAPK2)|Neuronal / cells hierarchy compared to all cells using T-Statistic

GPRIN3 CLSTN2 LRRK1 GRM3 ADAMTS12

9.25e-0520010158444ae3c10b1152dec67ca812e6c417cc3b9cf89
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 AFDN LTBP1

9.25e-05200101577ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CD177 GATA2 ACSL4 LTF HSD17B4

9.25e-052001015cad2d972aa6ea0cc9ebe5ec60fda6e306e9ee2b2
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-052001015f15fffefe372005c33e31845982e2d2714ac26af
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-052001015a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLT1 GATA2 ZNF521 FRY AFDN

9.25e-05200101589a6da2bdedc6b1ad0675c8753bf2b763a99af6a
ToppCellLPS_anti-TNF-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-0520010151d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCellLPS_IL1RA_TNF-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-052001015d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-052001015b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellLPS_anti-TNF-Endothelial-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 ZNF521 AFDN

9.25e-05200101560d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 FRY LTBP1

9.25e-052001015b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLNB FLT1 GATA2 AFDN LTBP1

9.25e-052001015b1ff8d61b567f85006d6d20093f9c803b6d34674
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13

4.01e-244610414DOID:5426 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P LRP2 USP17L22 USP17L15 USP17L13

2.72e-236910415DOID:1682 (implicated_via_orthology)
DiseaseAddicted to cocaine

GRM2 GRM3

3.68e-0531042C0858355
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5C KDM5D

7.35e-0541042DOID:0060809 (implicated_via_orthology)
DiseaseMyelodysplastic syndrome

TET2 GATA2

1.22e-0451042cv:C3463824
DiseaseMYELODYSPLASTIC SYNDROME

TET2 GATA2

1.22e-0451042614286
DiseaseLeukemia, Myelomonocytic, Chronic

TET2 KDM6A

1.83e-0461042C0023480
Diseaseinternet addiction disorder

FLNB ANK1 GRM3

2.15e-04331043EFO_0803368
Diseaseresponse to anticonvulsant

ZNF521 CLSTN2 LOXL4 CDH6

2.37e-04851044GO_0036277
DiseaseSchizophrenia

PSD ANK3 GRIK3 GRM2 CSMD2 GRM3 CFAP65 ADAMTS12 TET1 LRP2 TOP3B

2.87e-0488310411C0036341
Diseasesleep duration, low density lipoprotein cholesterol measurement

DHX38 ZNF827 HTT PCSK9

3.08e-04911044EFO_0004611, EFO_0005271
Diseasecognitive function measurement

ERCC4 TMPRSS13 FLYWCH1 POLR2A ZNF521 CLSTN2 GRM3 SHISA9 C1orf21 FGD4 FARP1 LOXL4 LTBP1 AJUBA

5.10e-04143410414EFO_0008354
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

ERCC4 ANKS1B GRIK3 GRM3 SHISA9

7.27e-042001045EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Diseaseangina pectoris

FLT1 DHX38 ADAMTS7 PCSK9

1.02e-031251044EFO_0003913
Diseaseforced expiratory volume, response to bronchodilator

TET2 SP100 FLYWCH1 GPRIN3 CLSTN2 ADAMTS7 FGD4

1.02e-034451047EFO_0004314, GO_0097366
Diseaserevision of total hip arthroplasty

RIPK4 ADAMTS12

1.09e-03141042EFO_0020973
DiseaseProteinuria

ADAMTS7 LRP2

1.25e-03151042HP_0000093
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5C KDM5D

1.43e-03161042DOID:0050888 (implicated_via_orthology)
DiseaseMYELODYSPLASTIC SYNDROME

TET2 ERCC4 GATA2

1.73e-03671043C3463824
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

TET2 FLT1 KDM5C KDM6A

1.89e-031481044C0279702
Diseaseneuroticism measurement, wellbeing measurement, depressive symptom measurement

SHISA9 FARP1

2.02e-03191042EFO_0007006, EFO_0007660, EFO_0007869
Diseaseunipolar depression, bipolar disorder

ERCC4 ANK3 GRIK3 SHISA9

2.29e-031561044EFO_0003761, MONDO_0004985
DiseaseDisproportionate short stature

FLNB OBSL1 ACAN

2.58e-03771043C0878659
DiseaseEpilepsy, Benign Psychomotor, Childhood

GRM2 GRM3

2.97e-03231042C0393672
DiseaseEpilepsy, Lateral Temporal

GRM2 GRM3

2.97e-03231042C0393682
Diseasefrailty measurement

ANK3 HTT

2.97e-03231042EFO_0009885
DiseaseUncinate Epilepsy

GRM2 GRM3

2.97e-03231042C0014558
DiseaseEpilepsy, Temporal Lobe

GRM2 GRM3

2.97e-03231042C0014556
Diseasecoronary artery disease

TET2 FLT1 RNLS DHX38 ZFPM1 DMXL1 ADAMTS7 ZNF827 FARP1 SF3A3 PCSK9

3.27e-03119410411EFO_0001645

Protein segments in the cluster

PeptideGeneStartEntry
QPHHCDLTNMDGVVT

AFDN

446

P55196
HHSNLIAGMTGQCER

ACSL4

291

O60488
LQGHAHISCMPGTVR

CSMD2

1941

Q7Z408
LVGHSMAICTRHPQG

CSMD2

2501

Q7Z408
HGCHMQRLNARQPPA

AJUBA

521

Q96IF1
QTPLHCAARIGHTNM

ANK1

471

P16157
ALHNMHRALCPNTTR

GRM2

391

Q14416
AHALHKMQRTLCPNT

GRM3

401

Q14832
QGTVTCEAPNSRMHH

ATP8B3

301

O60423
CHRGTTIMTHGNLAQ

CD177

211

Q8N6Q3
FRAMPNLVSLHLQHC

CHAD

71

O15335
IHPSHIAMQLTVGAC

CLSTN2

486

Q9H4D0
VSELCSLNINMHHDP

DMXL1

1756

Q9Y485
PQVFQSHCERRHGSM

ATXN7L1

111

Q9ULK2
LGLSHLSGMCQPHRS

ADAMTS12

361

P58397
TLGLSHVAGMCQPHR

ADAMTS7

356

Q9UKP4
HVAGMCQPHRSCSIN

ADAMTS7

361

Q9UKP4
ISAHPNLMSCNTRKH

ANKS1B

181

Q7Z6G8
ICQSSSGHMHALVLP

OBSL1

471

O75147
IHQVTCLGTEPHMAN

LOXL4

246

Q96JB6
NQPVTLDMRHSALCH

MB21D2

131

Q8IYB1
QEASMLHALQHPCIV

LRRK1

1306

Q38SD2
MECNGAISAHHNLPL

MTO1

386

Q9Y2Z2
QGHRIMVMRSHCHQP

FLYWCH1

646

Q4VC44
GKARMTLHCAFQPTH

CFAP65

521

Q6ZU64
GLPNHVHQMTADAVC

KDM6A

746

O15550
LMSHGVPVVRTNQCA

KDM5D

566

Q9BY66
NSHCVRFVPQEMGVH

FLNB

2151

O75369
PAEASMGTRVHCHQQ

PCSK9

541

Q8NBP7
GRQCMHPLSVHLTKQ

LTBP1

686

Q14766
CGSLTLQHHMLEPVQ

FGD4

336

Q96M96
HPTKSHSFRAMCQNG

CFHR2

246

P36980
AQVMGPPDRCQHAAH

FUBP3

301

Q96I24
HLVTNHMVCQPGSKG

ZFPM1

366

Q8IX07
SGHCHPDVATMLNIL

KLC3

241

Q6P597
GGHRRMLAQHCVDAN

LRP2

3301

P98164
RMAAAEHRHSSGLPC

NPIPB15

216

A6NHN6
MPHSQKSRHCELEQG

MAGEA13P

1

A6NCF6
VQRHMPTIRCQPSGH

ACAN

2481

P16112
HARLTGGQMCRPHLL

GATA2

76

P23769
RVNVHSPHRAMAALG

HTT

2906

P42858
ISCLQQLHMFAPRHV

HEATR5A

1046

Q86XA9
ERQAPHRGNTMVHVC

FARP1

901

Q9Y4F1
NIHCNTIAPNAGSRM

HSD17B4

186

P51659
GLVHQPRANMHISES

C1orf21

81

Q9H246
SPLHMATQGDHLNCV

ANK3

336

Q12955
NMQSCHAEALIHPTG

CDH6

596

P55285
HGLQHGSQIPCIQMA

FAM172BP

131

A6NC97
AMVANLIQCVPVHHR

FRY

1096

Q5TBA9
DCQLTMAHPHHFRGN

CELSR3

1756

Q9NYQ7
PQMTVNSLQCHRHKA

GRIK3

341

Q13003
LIHTPLTMPANQHTC

GPRIN3

121

Q6ZVF9
DPNAQCLRHGFMLHT

DCAF15

206

Q66K64
VCMQLVGRHLHLASP

D2HGDH

316

Q8N465
LRKHNNCMASHLTPA

CKMT1A

56

P12532
CSAHNMLPHLERIQV

TIGD6

286

Q17RP2
NTDLHGHNIGKRMTC

PSD

661

A5PKW4
RSCHLAMAPNHAVVS

LTF

606

P02788
TIHEIHCQRNIGMCP

TRAFD1

26

O14545
NSHTFNCRMLIHPPD

NCOA1

191

Q15788
PDLSGHFLANCMNRH

SHLD2

71

Q86V20
PQGHCNTDHMERDLN

SHISA9

196

B4DS77
GQIPEENMSLCHARH

SPATA31C1

1066

P0DKV0
RTPMHVACQHGQENI

RIPK4

586

P57078
LVRQRTGHHCPTAVM

TET1

1501

Q8NFU7
HPSCQHSLSMLGIGQ

TOP3B

711

O95985
CGHRASSRNGLQMHI

ZBTB48

441

P10074
NMHLRTHTGEKPFQC

ZBTB48

481

P10074
MLPVRHGNCNHEAQR

WFDC8

96

Q8IUA0
QEARLRCSPMKGHSH

TRBV18

36

A0A087X0M5
HPACLPMHGQTFSLN

TMPRSS13

431

Q9BYE2
PGCRKQGLVHRTHMS

ZCCHC17

36

Q9NP64
AAANCPGQMTLHHKP

RNLS

296

Q5VYX0
TCRGHLMAITRHGVN

POLR2A

1406

P24928
HCQMHPDLRNSLTGF

ZNF521

1006

Q96K83
THRIQMPSGLCAHLF

SERINC4

91

A6NH21
MICLPNGTVVHHINA

SELENON

526

Q9NZV5
CISPVANEMNHLPAH

SP100

16

P23497
CTMQAHITRALHNPG

USP17L18

126

D6R9N7
RPCLPTAQACTMSHH

FAM90A2P

366

Q658T7
CTMQAHITRALHNPG

USP17L5

126

A8MUK1
CTMQAHITRALHNPG

USP17L21

126

D6R901
CTMQAHITRALHNPG

USP17L13

126

C9JLJ4
SLTCRNHALHMPRGE

PPP1R3D

276

O95685
CTMQAHITRALHNPG

USP17L19

126

D6RCP7
VNIRTGMPCHLHPTS

DHX38

1091

Q92620
MHRTCTDHAPLAIAQ

UNQ9370/PRO34162

26

Q6UXP9
VARPPAMCSHFTQDH

ZNF141

71

Q15928
RHMVIHTGLKSHQCP

ZNF827

391

Q17R98
SCLARHQRMHTGEKP

ZNF841

466

Q6ZN19
CTMQAHITRALHNPG

USP17L12

126

C9JPN9
QCSLLNLHMRSHTGE

ZNF569

561

Q5MCW4
CTMQAHITRALHNPG

USP17L24

126

Q0WX57
KIHRMGVVAHACNPS

ZNF429

641

Q86V71
QRHEMVANPSVLCSH

ZNF66

66

Q6ZN08
QHPFHGRLTSNMVCK

USP30

221

Q70CQ3
HAHGMRCLGIPNTAH

SF3A3

431

Q12874
PGVNAKNCRSLMHHV

ERCC4

856

Q92889
HCQMHPDLRNSLTGF

ZNF423

1006

Q2M1K9
SIPMVKRPHNCNSHG

ZFP2

66

Q6ZN57
CTMQAHITRALHNPG

USP17L6P

126

Q6QN14
LTGRTMHCHLDAPAN

WDR24

16

Q96S15
NCPSSLSIHMRKHTG

ZNF699

401

Q32M78
CTMQAHITRALHNPG

USP17L22

126

D6RA61
HIMQAGQTLHLQCRG

FLT1

41

P17948
QQPQTESCHSQMHRP

TET2

966

Q6N021
CTMQAHITRALHNPG

USP17L15

126

C9J2P7
CTMQAHITRALHNPG

USP17L17

126

D6RBQ6
CTMQAHITRALHNPG

USP17L23

126

D6RBM5
NCHSGLIRHQMTHRG

ZNF282

556

Q9UDV7
CTMQAHITRALHNPG

USP17L20

126

D6RJB6
NHFGRRCATTPMAVH

UBR5

2261

O95071
CTMQAHITRALHIPG

USP17L10

126

C9JJH3
CTMQAHITRALHNPG

USP17L11

126

C9JVI0
MSHSRRAAPTQDQCH

nan

1

Q96M85
LMSHGVPVVRTNQCA

KDM5C

576

P41229