Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentCul4-RING E3 ubiquitin ligase complex

DCAF4L2 DDB2 DCAF4L1

1.85e-0438613GO:0080008
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

DCAF4L2 GAN CUL7 DDB2 DCAF4L1

3.84e-04212615GO:0031461
DomainLMF

LMF1 LMF2

1.01e-052602IPR009613
DomainLMF1

LMF1 LMF2

1.01e-052602PF06762
DomainWD40

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

1.88e-05259607PF00400
DomainWD40

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

2.34e-05268607SM00320
DomainWD40_repeat

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

2.57e-05272607IPR001680
DomainWD_REPEATS_1

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

2.95e-05278607PS00678
DomainWD_REPEATS_2

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

3.02e-05279607PS50082
DomainWD_REPEATS_REGION

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

3.02e-05279607PS50294
DomainWD40_repeat_dom

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

4.50e-05297607IPR017986
Domain-

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

9.23e-053336072.130.10.10
DomainWD40/YVTN_repeat-like_dom

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

9.58e-05335607IPR015943
DomainPAN

MST1L F11

2.11e-047602PS50948
DomainAPC_su10/DOC_dom

CUL7 ZZEF1

2.11e-047602IPR004939
DomainPan_app

MST1L F11

2.11e-047602IPR003609
DomainDOC

CUL7 ZZEF1

2.11e-047602PS51284
DomainPAN_1

MST1L F11

2.11e-047602PF00024
DomainAPC10

CUL7 ZZEF1

2.11e-047602SM01337
DomainANAPC10

CUL7 ZZEF1

2.11e-047602PF03256
DomainARM-type_fold

URB1 MROH2B INTS1 CUL7 IPO4 LYST

7.51e-04339606IPR016024
DomainApc4_WD40_dom

COPA GEMIN5

1.86e-0320602IPR024977
DomainANAPC4_WD40

COPA GEMIN5

1.86e-0320602PF12894
DomainWD40_repeat_CS

COPA GEMIN5 LYST DDB2

1.91e-03164604IPR019775
DomainKringle-like

PLA2R1 MST1L

4.73e-0332602IPR013806
DomainPeptidase_S1A

TMPRSS6 MST1L F11

5.74e-03113603IPR001314
DomainTRYPSIN_DOM

TMPRSS6 MST1L F11

6.03e-03115603PS50240
DomainTryp_SPc

TMPRSS6 MST1L F11

6.32e-03117603SM00020
DomainTrypsin

TMPRSS6 MST1L F11

6.94e-03121603PF00089
DomainTrypsin_dom

TMPRSS6 MST1L F11

6.94e-03121603IPR001254
DomainPeptidase_S1_PA

TMPRSS6 MST1L F11

7.26e-03123603IPR009003
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

RASGRP4 PTPN13 COPA INTS1 ZDHHC16 CUL7 IPO4 DYNC1H1

1.40e-0732264826514267
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DIP2A URB1 IL17RE SCN5A INTS1 GEMIN5 PLA2G6 CABIN1 ZZEF1 LYST DYNC1H1 SMG6

7.14e-071105641235748872
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

BPTF URB1 COPA UTP4 INTS1 GEMIN5 CUL7 IPO4 DYNC1H1

3.01e-0665364922586326
Pubmed

Novel mutations in PANK2 and PLA2G6 genes in patients with neurodegenerative disorders: two case reports.

PANK2 PLA2G6

3.33e-06264228821231
Pubmed

Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia.

LMF1 LMF2

3.33e-06264217994020
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

URB1 GPR158 ALS2 CAMTA1 SMG6 STAB1

3.76e-0622564612168954
Pubmed

Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis.

PMEL CABIN1

9.99e-06364234503492
Pubmed

The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.

PTPN13 GIT1

9.99e-06364223108400
Pubmed

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

COPA CUL7 DYNC1H1

1.17e-052464333705438
Pubmed

Neurodegeneration with brain iron accumulation.

PANK2 PLA2G6

2.00e-05464229325618
Pubmed

Mitochondria: A crossroads for lipid metabolism defect in neurodegeneration with brain iron accumulation diseases.

PANK2 PLA2G6

2.00e-05464225668476
Pubmed

mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs.

DIP2A URB1

2.00e-05464214637006
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

BPTF PATL2 UTP4 ZDHHC16 PLA2G6 ALS2

3.07e-0532664617015433
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

BPTF DCAF4L2 UTP4 ALS2 CABIN1 DCAF4L1

5.58e-0536364614691545
Pubmed

Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

GPR158 SCN5A

6.96e-05764225217174
Pubmed

Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.

ADAMTS16 ZZEF1

9.27e-05864224039173
Pubmed

Transgenic mouse models for ADHD.

THRB GIT1

1.19e-04964223681253
Pubmed

Neurodegeneration with Brain Iron Accumulation Disorders Overview

PANK2 PLA2G6

1.49e-041064223447832
Pubmed

Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.

COPA GIT1

3.45e-041564236963288
Pubmed

Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.

PMEL LYST

3.45e-041564218715234
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BPTF LMF1 PTPN13 THRB GPR158 TMPRSS6 PLA2G6 CAMTA1 GDE1 SMG6

3.69e-041489641028611215
Pubmed

Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.

IPO4 DDB2

4.45e-041764217609381
Pubmed

The contribution of de novo coding mutations to autism spectrum disorder.

DIP2A DSCAM

5.00e-041864225363768
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

URB1 DSCAM GEMIN5 USP54

5.34e-0420264424639526
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DIP2A PTPN13 DSCAM COPA GIT1 USP54 CABIN1 DYNC1H1 STAB1

5.52e-04128564935914814
Pubmed

Identification of novel spartin-interactors shows spartin is a multifunctional protein.

COPA DYNC1H1

5.59e-041964219765186
Pubmed

The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.

TPO THRB

6.20e-042064224265449
Pubmed

A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.

PTPN13 GEMIN5

6.84e-042164224923560
Pubmed

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

DCAF4L2 DDB2 DCAF4L1

8.22e-049964334161765
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

PTPN13 GEMIN5 USP54 DYNC1H1

8.96e-0423264425515538
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PTPN13 PANK2 GIT1 GAN ALS2 USP54 LYST

1.01e-0386164736931259
Pubmed

The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.

TPO HMGCR

1.14e-03276428390965
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

INTS1 CUL7 IPO4 SMG6

1.83e-0328264423667531
CytobandEnsembl 112 genes in cytogenetic band chr21q22

DIP2A URB1 DSCAM PLAC4 ZNF295-AS1

1.86e-04377645chr21q22
Cytoband21q22.2

DSCAM PLAC4

9.82e-043364221q22.2
Cytoband22q12.3

FOXRED2 TMPRSS6

9.82e-043364222q12.3
GeneFamilyWD repeat domain containing

DCAF4L2 COPA UTP4 GEMIN5 LYST DDB2 DCAF4L1

1.28e-06262397362
Diseasefunctional impairment measurement

ADAMTS16 ZZEF1

9.06e-057622EFO_0005412
DiseaseAutoimmune Diseases

TPO COPA HMGCR

9.57e-0542623C0004364
DiseaseNeurodegeneration with brain iron accumulation

PANK2 PLA2G6

3.34e-0413622cv:C2931845
Diseasehemoglobin measurement, mean corpuscular hemoglobin

THRB TMPRSS6

9.77e-0422622EFO_0004509, EFO_0004527
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

BPTF LMF1 PLA2G6 HMGCR

1.28e-03224624EFO_0004530, EFO_0008317
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

THRB GIT1

1.59e-0328622DOID:1094 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
TRLEIWIHPSHPRSS

SMG6

851

Q86US8
ALPTLPSSQHDWLSL

CAMTA1

956

Q9Y6Y1
VSLHRPWESSPSIHI

ERVK13-1

261

Q9NX77
HHVFPLATLWAEPLS

ALS2

951

Q96Q42
SIVKHLRHSAWPPTL

GIT1

46

Q9Y2X7
NIPSSFLHPNWASHR

BPTF

916

Q12830
VTSRTWELAHQPLHS

ADAMTS16

221

Q8TE57
SQMEPRTHPTWLLHI

PDCD1LG2

211

Q9BQ51
KHLLTTHVHSPWTPS

PLAC4

11

Q8WY50
DTLTHPRHRHSSPWT

PLAC4

36

Q8WY50
HPHSPWIPSLLTLDT

PLAC4

76

Q8WY50
LTLFTHQSSWPTLHQ

INTS1

1661

Q8N201
LPWTQHSPHSRLWHS

MST1L

86

Q2TV78
KWPALASAHPSLHRA

GPR158

111

Q5T848
LVHAHSRWIADPSPQ

HMGCR

266

P04035
LPHWNTRCPLASHTD

IL17RE

31

Q8NFR9
WSLHDAHLLRTIPSP

DCAF4L1

341

Q3SXM0
WSLRHGHLLTTIPSP

DCAF4L2

341

Q8NA75
PSLTALHTLWLREHN

TPO

401

P07202
LWPAQRALNSHLLHS

CSNKA2IP

111

A0A1B0GTH6
RHSWPVASICHTLNP

CUL7

1396

Q14999
QLRHAWTQTESPHPS

RASGRP4

636

Q8TDF6
TWLRLHQLHTPATAA

MPND

161

Q8N594
TLPHTAWPLSFLHQT

PRNT

46

Q86SH4
DRRATSLAWHPTHPS

DDB2

111

Q92466
RHHSVTWPATELPIT

FOXRED2

416

Q8IWF2
PTLVSTWEHDLPSHR

IRGC

226

Q6NXR0
PPHLRHRESWSSTKG

PCF11

616

O94913
VHWAAPPSLSSGLHR

PANK2

11

Q9BZ23
LTSWPPRFSHLTQLH

PATL2

141

C9JE40
ITALTHRPWSLSHTG

GDE1

221

Q9NZC3
HSWRRHSTSLPNPLL

CABIN1

516

Q9Y6J0
SFHPKRPWILTSLHN

COPA

16

P53621
TGTWHHTKPLLPSDL

GAN

551

Q9H2C0
WQVTLHTTSPTQRHL

F11

401

P03951
ESFPHRLLSSWHIAP

LYST

1441

Q99698
HTTASNWLHLIPQTL

DYNC1H1

4381

Q14204
LQWRAHTTPDHPLFL

DIP2A

991

Q14689
MLHASTIWHLRSTPP

H1-9P

1

P60008
WPQLLQLLQHSTHSP

IPO4

116

Q8TEX9
HHISEPTRQENWTPL

PTPN13

1756

Q12923
HPTISAHTLTTDWRL

DSCAM

1756

O60469
SRILSLSWHPSGTHI

UTP4

146

Q969X6
WLQRDTPITHISFHP

UTP4

576

Q969X6
HTHSPWFTSLVLRLL

LMF2

516

Q9BU23
SHHTSLLVPWPLRRT

SCN5A

556

Q14524
RFPHSNLTHSLSLPW

TEKT3

36

Q9BXF9
TDLIRNHPSWSVAHL

PLA2G6

111

O60733
LWTLLSSPSTHHIGV

MROH2B

1231

Q7Z745
SVPQLPHSSSHWLRL

PMEL

626

P40967
PSLLHTPSSHKRWIV

URB1

1346

O60287
TNWHTLEPHIFPNRS

PLA2R1

461

Q13018
LLSEQHPAHPTWTLT

AQP11

66

Q8NBQ7
PWLTGHKPLARHASS

C11orf16

46

Q9NQ32
RWSKTASPPVSLHHR

nan

76

Q8TAT8
PHLIQTTWTSSIFHL

THRB

56

P10828
LSSHTRIPRANHWDL

PRRG2

41

O14669
ALHQHTISTLHWSPR

GEMIN5

106

Q8TEQ6
IISPAGPHALTWTTH

UNQ5815/PRO19632

56

Q6UWF5
LHSLGLRSVWVHPSL

STAB1

1921

Q9NY15
VFSLARHHSPSPWIA

TGM5

76

O43548
RLHSNSLQHVPPRWF

TLR7

296

Q9NYK1
HWLTRVLLPSSHLPH

ZDHHC16

341

Q969W1
LAWNTSAHPRHAITL

ZACN

96

Q401N2
SAHPRHAITLPWESL

ZACN

101

Q401N2
HVLASLLAEWPSHVP

ZZEF1

2621

O43149
QSHRRLLAPPSSSWT

ZNF295-AS1

31

Q8N0V1
SPQTHCSWHLTVPSL

TMPRSS6

361

Q8IU80
GLVPSWRHIPKSHSS

USP54

696

Q70EL1
PSSSLHVPLRSAWNS

USP54

1606

Q70EL1
PASTWHLQDQPISRH

GARIN5B

181

Q8N5Q1
WTLSRLPQHTPTSRI

LMF1

191

Q96S06