Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR1A1 AKR1C1 AKR1C2	6.30e-05	14	114	3	GO:0004032
GeneOntologyMolecularFunction	androsterone dehydrogenase (B-specific) activity	AKR1C1 AKR1C2	1.92e-04	4	114	2	GO:0047042
GeneOntologyMolecularFunction	ketoreductase activity	AKR1C1 AKR1C2	1.92e-04	4	114	2	GO:0045703
GeneOntologyMolecularFunction	indanol dehydrogenase activity	AKR1C1 AKR1C2	1.92e-04	4	114	2	GO:0047718
GeneOntologyMolecularFunction	chlordecone reductase activity	AKR1C1 AKR1C2	1.92e-04	4	114	2	GO:0047743
GeneOntologyMolecularFunction	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	AKR1C1 AKR1C2	3.19e-04	5	114	2	GO:0047115
GeneOntologyMolecularFunction	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	3.19e-04	5	114	2	GO:0047020
GeneOntologyMolecularFunction	17-beta-ketosteroid reductase (NADPH) activity	AKR1C1 AKR1C2	3.19e-04	5	114	2	GO:0072555
GeneOntologyMolecularFunction	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	AKR1C1 AKR1C2	3.19e-04	5	114	2	GO:0047006
GeneOntologyMolecularFunction	lithocholic acid binding	AKR1C1 AKR1C2	3.19e-04	5	114	2	GO:1902121
GeneOntologyMolecularFunction	ketosteroid monooxygenase activity	AKR1C1 AKR1C2	3.19e-04	5	114	2	GO:0047086
GeneOntologyMolecularFunction	Delta4-3-oxosteroid 5beta-reductase activity	AKR1C1 AKR1C2	3.19e-04	5	114	2	GO:0047787
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	AKR1A1 AKR1C1 AKR1C2	3.36e-04	24	114	3	GO:0004745
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	AKR1A1 AKR1C1 AKR1C2	4.28e-04	26	114	3	GO:0004022
GeneOntologyMolecularFunction	geranylgeranyl reductase activity	AKR1C1 AKR1C2	4.77e-04	6	114	2	GO:0045550
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	AKR1A1 AKR1C1 AKR1C2	4.80e-04	27	114	3	GO:0008106
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	AKR1A1 AKR1C1 AKR1C2	6.58e-04	30	114	3	GO:0018455
GeneOntologyMolecularFunction	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	6.66e-04	7	114	2	GO:0072582
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	AKR1A1 AKR1C1 AKR1C2	7.97e-04	32	114	3	GO:0004033
GeneOntologyMolecularFunction	5alpha-androstane-3beta,17beta-diol dehydrogenase activity	AKR1C1 AKR1C2	8.85e-04	8	114	2	GO:0047024
GeneOntologyMolecularFunction	androsterone dehydrogenase activity	AKR1C1 AKR1C2	8.85e-04	8	114	2	GO:0047023
GeneOntologyMolecularFunction	enone reductase activity	AKR1C1 AKR1C2	8.85e-04	8	114	2	GO:0035671
GeneOntologyMolecularFunction	androstan-3-alpha,17-beta-diol dehydrogenase activity	AKR1C1 AKR1C2	1.13e-03	9	114	2	GO:0047044
GeneOntologyMolecularFunction	NADP+ binding	AKR1C1 AKR1C2	1.13e-03	9	114	2	GO:0070401
GeneOntologyMolecularFunction	testosterone 17-beta-dehydrogenase (NADP+) activity	AKR1C1 AKR1C2	1.41e-03	10	114	2	GO:0047045
GeneOntologyMolecularFunction	bile acid binding	AKR1C1 AKR1C2	1.41e-03	10	114	2	GO:0032052
GeneOntologyMolecularFunction	retinal dehydrogenase activity	AKR1C1 AKR1C2	2.81e-03	14	114	2	GO:0001758
GeneOntologyBiologicalProcess	daunorubicin metabolic process	AKR1A1 AKR1C1 AKR1C2	1.28e-05	9	112	3	GO:0044597
GeneOntologyBiologicalProcess	doxorubicin metabolic process	AKR1A1 AKR1C1 AKR1C2	1.82e-05	10	112	3	GO:0044598
GeneOntologyBiologicalProcess	polyketide metabolic process	AKR1A1 AKR1C1 AKR1C2	1.82e-05	10	112	3	GO:0030638
GeneOntologyBiologicalProcess	aminoglycoside antibiotic metabolic process	AKR1A1 AKR1C1 AKR1C2	1.82e-05	10	112	3	GO:0030647
GeneOntologyBiologicalProcess	positive regulation of calcium-mediated signaling	AKAP6 LMCD1 L1CAM PTPRC SYK	3.94e-05	70	112	5	GO:0050850
GeneOntologyBiologicalProcess	response to jasmonic acid	AKR1C1 AKR1C2	1.74e-04	4	112	2	GO:0009753
GeneOntologyBiologicalProcess	progesterone catabolic process	AKR1C1 AKR1C2	1.74e-04	4	112	2	GO:0006709
GeneOntologyBiologicalProcess	cellular response to jasmonic acid stimulus	AKR1C1 AKR1C2	1.74e-04	4	112	2	GO:0071395
GeneOntologyBiologicalProcess	positive regulation of protein import	ARHGEF5 HNRNPM	1.74e-04	4	112	2	GO:1904591
GeneOntologyBiologicalProcess	C21-steroid hormone catabolic process	AKR1C1 AKR1C2	1.74e-04	4	112	2	GO:0008208
GeneOntologyBiologicalProcess	glycoside metabolic process	AKR1A1 AKR1C1 AKR1C2	2.23e-04	22	112	3	GO:0016137
GeneOntologyBiologicalProcess	tertiary alcohol metabolic process	AKR1A1 AKR1C1 AKR1C2	2.23e-04	22	112	3	GO:1902644
GeneOntologyBiologicalProcess	farnesol metabolic process	AKR1C1 AKR1C2	2.89e-04	5	112	2	GO:0016487
GeneOntologyBiologicalProcess	farnesol catabolic process	AKR1C1 AKR1C2	2.89e-04	5	112	2	GO:0016488
GeneOntologyBiologicalProcess	negative regulation of isoprenoid metabolic process	AKR1C1 AKR1C2	2.89e-04	5	112	2	GO:0045827
GeneOntologyBiologicalProcess	sesquiterpenoid catabolic process	AKR1C1 AKR1C2	2.89e-04	5	112	2	GO:0016107
GeneOntologyBiologicalProcess	olefinic compound catabolic process	AKR1C1 AKR1C2	2.89e-04	5	112	2	GO:0120256
GeneOntologyBiologicalProcess	regulation of protein import	ARHGEF5 HNRNPM	2.89e-04	5	112	2	GO:1904589
GeneOntologyBiologicalProcess	negative regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	2.89e-04	5	112	2	GO:1900053
GeneOntologyBiologicalProcess	sesquiterpenoid metabolic process	AKR1C1 AKR1C2	4.32e-04	6	112	2	GO:0006714
GeneOntologyBiologicalProcess	polyprenol catabolic process	AKR1C1 AKR1C2	4.32e-04	6	112	2	GO:0016095
GeneOntologyBiologicalProcess	secondary metabolic process	AKR1A1 AKR1C1 AKR1C2 SLC45A2	4.85e-04	67	112	4	GO:0019748
GeneOntologyBiologicalProcess	regulation of calcium-mediated signaling	AKAP6 LMCD1 L1CAM PTPRC SYK	5.20e-04	121	112	5	GO:0050848
GeneOntologyBiologicalProcess	response to prostaglandin D	AKR1C1 AKR1C2	6.03e-04	7	112	2	GO:0071798
GeneOntologyBiologicalProcess	cellular response to prostaglandin D stimulus	AKR1C1 AKR1C2	6.03e-04	7	112	2	GO:0071799
GeneOntologyBiologicalProcess	regulation of retinoic acid biosynthetic process	AKR1C1 AKR1C2	6.03e-04	7	112	2	GO:1900052
GeneOntologyCellularComponent	anchoring junction	AKAP6 PRICKLE4 FLNC XIRP1 EPPK1 DSG3 ARHGEF5 FBF1 L1CAM OBSL1 AKAP12 DST PTPRC ARHGAP31 AHNAK C19orf84 CDH11	1.70e-05	976	112	17	GO:0070161
GeneOntologyCellularComponent	cell-cell contact zone	AKAP6 XIRP1 OBSL1 DST AHNAK	1.52e-04	94	112	5	GO:0044291
GeneOntologyCellularComponent	Z disc	PRICKLE4 FLNC OBSL1 DST MYO18B AHNAK2	1.64e-04	151	112	6	GO:0030018
GeneOntologyCellularComponent	costamere	FLNC AHNAK AHNAK2	2.14e-04	22	112	3	GO:0043034
GeneOntologyCellularComponent	I band	PRICKLE4 FLNC OBSL1 DST MYO18B AHNAK2	2.74e-04	166	112	6	GO:0031674
GeneOntologyCellularComponent	cell-cell junction	AKAP6 PRICKLE4 XIRP1 EPPK1 DSG3 FBF1 OBSL1 DST AHNAK C19orf84 CDH11	3.34e-04	591	112	11	GO:0005911
GeneOntologyCellularComponent	intercalated disc	AKAP6 XIRP1 OBSL1 DST	4.88e-04	68	112	4	GO:0014704
GeneOntologyCellularComponent	cell-substrate junction	FLNC XIRP1 EPPK1 L1CAM AKAP12 DST PTPRC ARHGAP31 AHNAK	6.37e-04	443	112	9	GO:0030055
GeneOntologyCellularComponent	myofibril	PRICKLE4 FLNC OBSL1 DST AHNAK MYO18B AHNAK2	6.77e-04	273	112	7	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	PRICKLE4 FLNC OBSL1 DST AHNAK MYO18B AHNAK2	9.64e-04	290	112	7	GO:0043292
GeneOntologyCellularComponent	hemidesmosome	EPPK1 DST	1.52e-03	11	112	2	GO:0030056
GeneOntologyCellularComponent	sarcomere	PRICKLE4 FLNC OBSL1 DST MYO18B AHNAK2	2.25e-03	249	112	6	GO:0030017
GeneOntologyCellularComponent	focal adhesion	FLNC XIRP1 L1CAM AKAP12 DST PTPRC ARHGAP31 AHNAK	2.25e-03	431	112	8	GO:0005925
Domain	ZnF_C2HC	FAM90A14 RBBP6 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	9.34e-10	55	108	8	SM00343
Domain	Znf_CCHC	FAM90A14 RBBP6 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	9.34e-10	55	108	8	IPR001878
Domain	NUT	NUTM2A NUTM2G NUTM2B NUTM2F	5.26e-09	5	108	4	IPR024310
Domain	NUT_N	NUTM2A NUTM2G NUTM2B NUTM2F	5.26e-09	5	108	4	IPR024309
Domain	NUT	NUTM2A NUTM2G NUTM2B NUTM2F	5.26e-09	5	108	4	PF12881
Domain	ALDOKETO_REDUCTASE_1	AKR1A1 AKR1C1 AKR1C2	2.19e-05	10	108	3	PS00798
Domain	Aldo/ket_reductase_CS	AKR1A1 AKR1C1 AKR1C2	2.19e-05	10	108	3	IPR018170
Domain	Aldo/keto_reductase	AKR1A1 AKR1C1 AKR1C2	2.19e-05	10	108	3	IPR020471
Domain	ALDOKETO_REDUCTASE_2	AKR1A1 AKR1C1 AKR1C2	2.19e-05	10	108	3	PS00062
Domain	ALDOKETO_REDUCTASE_3	AKR1A1 AKR1C1 AKR1C2	2.19e-05	10	108	3	PS00063
Domain	ARHGEF5_35	ARHGEF5 ARHGEF35	3.31e-05	2	108	2	PF15441
Domain	ARHGEF5/35_N	ARHGEF5 ARHGEF35	3.31e-05	2	108	2	IPR029212
Domain	-	AKR1A1 AKR1C1 AKR1C2	9.97e-05	16	108	3	3.20.20.100
Domain	NADP_OxRdtase_dom	AKR1A1 AKR1C1 AKR1C2	1.21e-04	17	108	3	IPR023210
Domain	Aldo_ket_red	AKR1A1 AKR1C1 AKR1C2	1.21e-04	17	108	3	PF00248
Domain	Aldo/ket_red/Kv-b	AKR1A1 AKR1C1 AKR1C2	1.21e-04	17	108	3	IPR001395
Domain	PET	PRICKLE4 LMCD1	4.89e-04	6	108	2	PF06297
Domain	-	EPPK1 DST	4.89e-04	6	108	2	3.90.1290.10
Domain	PET_domain	PRICKLE4 LMCD1	4.89e-04	6	108	2	IPR010442
Domain	PET	PRICKLE4 LMCD1	4.89e-04	6	108	2	PS51303
Domain	Plectin_repeat	EPPK1 DST	6.83e-04	7	108	2	IPR001101
Domain	Plectin	EPPK1 DST	6.83e-04	7	108	2	PF00681
Domain	PLEC	EPPK1 DST	6.83e-04	7	108	2	SM00250
Domain	FN3	FLNC L1CAM OBSL1 DSCAML1 PTPRC	4.43e-03	185	108	5	SM00060
Domain	-	SMCHD1 TOP2A	5.88e-03	20	108	2	3.30.565.10
Domain	GPCR_3	GPR179 GPR158	6.48e-03	21	108	2	IPR000337
Domain	HATPase_C	SMCHD1 TOP2A	6.48e-03	21	108	2	IPR003594
Domain	7tm_3	GPR179 GPR158	7.10e-03	22	108	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GPR179 GPR158	7.10e-03	22	108	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GPR179 GPR158	7.10e-03	22	108	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GPR179 GPR158	7.10e-03	22	108	2	PS00979
Pathway	WP_BENZOAPYRENE_METABOLISM	AKR1A1 AKR1C1 AKR1C2	7.01e-06	9	63	3	M39344
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY	AKR1A1 AKR1C1 AKR1C2	7.01e-06	9	63	3	M47817
Pathway	KEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM	AKR1A1 AKR1C1 AKR1C2	1.37e-05	11	63	3	M47812
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A2P FAM90A1 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.25e-26	25	119	13	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A2P FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10	6.12e-22	23	119	11	18602769
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A1 FAM90A17 FAM90A19 FAM90A22 FAM90A26 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A10	1.24e-11	164	119	11	22967998
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RBBP6 SMCHD1 HNRNPM HLCS TACC2 GPKOW NSRP1 AKAP12 UBE2O SAFB DST MTHFD1 AHNAK EIF4B NCOA7 EIF3G TOP2A AHNAK2	3.25e-09	934	119	18	33916271
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLNC UBA2 GPKOW NSRP1 AKAP12 SAFB GANAB DST AHNAK SRRM2 TIMM44 AHNAK2	4.43e-09	360	119	12	33111431
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	HNRNPM TACC2 NSRP1 SAFB AHNAK EIF4B CPSF1 SRRM2	1.70e-08	130	119	8	35545047
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EPPK1 SMCHD1 HNRNPM UBA2 RNF213 SAFB MTHFD1 AHNAK SRRM2 TOP2A AHNAK2	2.14e-08	332	119	11	32786267
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	FLNC SMCHD1 HNRNPM TACC2 ZHX2 GPKOW SAFB AHNAK EIF4B EIF3G TOP2A AHNAK2	4.48e-08	444	119	12	34795231
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	ACAP1 EPPK1 RBBP6 HNRNPM OBSL1 NSRP1 SAFB GANAB DST MTHFD1 AHNAK EIF4B CPSF1 SRRM2 TOP2A	9.16e-07	949	119	15	36574265
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 PRUNE2 CUX2 OBSL1 DSCAML1 DST UBR5 GPR158	1.15e-06	225	119	8	12168954
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ARHGAP23 RBBP6 FBF1 HNRNPM OBSL1 HLCS RNF213 C16orf96 NSRP1 INTS10 UBR5 RCOR3 DNA2 SRRM2 TOP2A SLC39A7	1.38e-06	1116	119	16	31753913
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	RBBP6 HNRNPM WASHC2A GPKOW NSRP1 UBE2O DST INF2 MTHFD1 CPSF1 SRRM2	1.42e-06	506	119	11	30890647
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FLNC EPPK1 HNRNPM UBA2 AKR1A1 AKAP12 UBE2O GANAB DST UBR5 MTHFD1 AHNAK EIF4B NEMF EIF3G SRRM2	2.01e-06	1149	119	16	35446349
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SETD1A RBBP6 SMCHD1 OBSL1 AHNAK PRDM12 RCOR3 EIF3G DNA2 TOP2A	5.19e-06	469	119	10	27634302
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	SETD1A SGSM1 FBF1 UBA2 NUTM2D WASHC2A GALNT18 INKA2 NUTM2G NUTM2E SLC38A10 NUTM2B CRACDL KDM7A ECI2 NUTM2F	5.40e-06	1242	119	16	30973865
Pubmed	The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.	HNRNPM C16orf96 AHNAK EIF3G TOP2A	5.75e-06	74	119	5	35102251
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	FLNC EPPK1 HNRNPM UBE2O GANAB DST MTHFD1 AHNAK EIF4B SRRM2	6.02e-06	477	119	10	31300519
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EPPK1 SMCHD1 HNRNPM TACC2 UBE2O GANAB UBR5 MTHFD1 AHNAK EIF4B NEMF ECI2 EIF3G SRRM2 TIMM44 TOP2A AHNAK2	6.72e-06	1415	119	17	28515276
Pubmed	Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.	AKR1C1 AKR1C2	1.16e-05	2	119	2	8573067
Pubmed	Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.	AKR1C1 AKR1C2	1.16e-05	2	119	2	11514561
Pubmed	Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.	AKR1C1 AKR1C2	1.16e-05	2	119	2	15492289
Pubmed	The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors.	GPR179 GPR158	1.16e-05	2	119	2	16229975
Pubmed	cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.	AKR1C1 AKR1C2	1.16e-05	2	119	2	8011662
Pubmed	The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.	AHNAK AHNAK2	1.16e-05	2	119	2	15007166
Pubmed	AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.	AHNAK AHNAK2	1.16e-05	2	119	2	20833135
Pubmed	Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.	AKR1C1 AKR1C2	1.16e-05	2	119	2	18654764
Pubmed	Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.	AKR1C1 AKR1C2	1.16e-05	2	119	2	21217827
Pubmed	The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.	AKR1C1 AKR1C2	1.16e-05	2	119	2	26934124
Pubmed	cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.	AKR1C1 AKR1C2	1.16e-05	2	119	2	8486699
Pubmed	Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction.	GANAB PTPRC	1.16e-05	2	119	2	10921916
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	EPPK1 FBF1 HNRNPM OBSL1 FAM117B FAM90A1 GALNT18 AKAP12 UBR5 SRRM2 TIMM44	1.30e-05	639	119	11	23443559
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	FLNC SLC38A10 UBR5 EIF4B ECI2 TOP2A SLC39A7	1.55e-05	231	119	7	36597993
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SETD1A FLNC ARHGAP23 SMCHD1 HNRNPM SAFB DST UBR5 INF2 MTHFD1 AHNAK CPSF1 SRRM2 TIMM44 TOP2A AHNAK2	1.56e-05	1353	119	16	29467282
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	RGPD4 EPPK1 RBBP6 SMCHD1 HNRNPM SAFB GANAB AHNAK CPSF1 SRRM2 TOP2A	1.56e-05	652	119	11	31180492
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	UBA2 UBE2O DST UBR5 AHNAK EIF4B EIF3G MYO18B TOP2A AHNAK2	1.70e-05	538	119	10	28524877
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	FLNC EMC7 EPPK1 HNRNPM RNF213 AKR1A1 GPKOW AKAP12 UBE2O SAFB INF2 AHNAK EIF4B EIF3G TOP2A AHNAK2	1.77e-05	1367	119	16	32687490
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	BDP1 RBBP6 HNRNPM RNF213 DNA2 SRRM2 TOP2A	2.58e-05	250	119	7	33536335
Pubmed	Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.	AKR1C1 AKR1C2	3.47e-05	3	119	2	19320734
Pubmed	Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.	AKR1C1 AKR1C2	3.47e-05	3	119	2	31780644
Pubmed	The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor.	NUTM2A NUTM2B	3.47e-05	3	119	2	22456610
Pubmed	Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45.	GANAB PTPRC	3.47e-05	3	119	2	11564800
Pubmed	Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs.	FLNC XIRP1	3.47e-05	3	119	2	19843512
Pubmed	Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.	AKR1C1 AKR1C2	3.47e-05	3	119	2	21232532
Pubmed	Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II.	GANAB PTPRC	3.47e-05	3	119	2	9148925
Pubmed	Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.	AKR1C1 AKR1C2	3.47e-05	3	119	2	13678667
Pubmed	Interleukin 1β regulates progesterone metabolism in human cervical fibroblasts.	AKR1C1 AKR1C2	3.47e-05	3	119	2	22064385
Pubmed	Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.	FLNC XIRP1	3.47e-05	3	119	2	27206985
Pubmed	Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase.	PTPRC SYK	3.47e-05	3	119	2	9324357
Pubmed	A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients.	FLNC XIRP1	3.47e-05	3	119	2	23115302
Pubmed	Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.	AKR1A1 AKR1C1	3.47e-05	3	119	2	10510318
Pubmed	Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance.	FLNC XIRP1	3.47e-05	3	119	2	24963132
Pubmed	Self-regulated alternative splicing at the AHNAK locus.	AHNAK AHNAK2	3.47e-05	3	119	2	21940993
Pubmed	Differential involvement of sarcomeric proteins in myofibrillar myopathies: a morphological and immunohistochemical study.	FLNC XIRP1	3.47e-05	3	119	2	19151983
Pubmed	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	NUTM2E NUTM2B	3.47e-05	3	119	2	26542179
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ANKRD35 RBBP6 SMCHD1 FBF1 SAFB EIF4B MYO18B SRRM2	3.59e-05	361	119	8	26167880
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	EMC7 EPPK1 RBBP6 SMCHD1 L1CAM AKAP12 GANAB DST UBR5 MTHFD1 AHNAK EIF4B NEMF SRRM2 SLC39A7	3.80e-05	1297	119	15	33545068
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	HNRNPM RNF213 AKR1C2 MTHFD1 AHNAK SRRM2 AHNAK2	4.01e-05	268	119	7	33024031
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RGPD4 TACC2 WASHC2A GPKOW AKAP12 GANAB UBR5 INF2 AHNAK EIF4B RCOR3 CEP152 EIF3G TOP2A	4.24e-05	1155	119	14	20360068
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	RBBP6 SMCHD1 UBA2 RNF213 GPKOW AKR1C1 AKR1C2 SAFB UBR5 AHNAK CPSF1 EIF3G TOP2A	4.60e-05	1014	119	13	32416067
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNC EPPK1 SMCHD1 OBSL1 SAFB GANAB DST UBR5 MTHFD1 AHNAK CPSF1 SRRM2 TOP2A	5.08e-05	1024	119	13	24711643
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	EPPK1 UBR5 SRRM2 SLC39A7	5.13e-05	59	119	4	16083285
Pubmed	Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.	AKR1C1 AKR1C2	6.93e-05	4	119	2	20124700
Pubmed	Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).	AKR1C1 AKR1C2	6.93e-05	4	119	2	10500239
Pubmed	Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.	AKR1C1 AKR1C2	6.93e-05	4	119	2	16508162
Pubmed	AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.	AKR1C1 AKR1C2	6.93e-05	4	119	2	19487289
Pubmed	Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	6.93e-05	4	119	2	14967952
Pubmed	Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.	AKR1C1 AKR1C2	6.93e-05	4	119	2	10393440
Pubmed	Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.	AKR1C1 AKR1C2	6.93e-05	4	119	2	15193432
Pubmed	Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.	AKR1C1 AKR1C2	6.93e-05	4	119	2	31479646
Pubmed	Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.	PTPRC SYK	6.93e-05	4	119	2	23281368
Pubmed	Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	6.93e-05	4	119	2	15222881
Pubmed	Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.	AKR1C1 AKR1C2	6.93e-05	4	119	2	16191478
Pubmed	Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.	AKR1C1 AKR1C2	6.93e-05	4	119	2	15577209
Pubmed	AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.	AHNAK AHNAK2	6.93e-05	4	119	2	17185750
Pubmed	Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.	AKR1C1 AKR1C2	6.93e-05	4	119	2	10702227
Pubmed	Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.	AKR1C1 AKR1C2	6.93e-05	4	119	2	17034817
Pubmed	Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.	AKR1C1 AKR1C2	6.93e-05	4	119	2	17629694
Pubmed	RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.	AKR1C1 AKR1C2	6.93e-05	4	119	2	29764944
Pubmed	Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.	AKR1C1 AKR1C2	6.93e-05	4	119	2	10526179
Pubmed	Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.	AKR1C1 AKR1C2	6.93e-05	4	119	2	17888864
Pubmed	Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.	AKR1C1 AKR1C2	6.93e-05	4	119	2	17442338
Pubmed	Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.	AKR1C1 AKR1C2	6.93e-05	4	119	2	28329705
Pubmed	Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.	AKR1C1 AKR1C2	6.93e-05	4	119	2	16018803
Pubmed	Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.	AKR1C1 AKR1C2	6.93e-05	4	119	2	17272929
Pubmed	Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.	AKR1C1 AKR1C2	6.93e-05	4	119	2	19237748
Pubmed	Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.	AKR1C1 AKR1C2	6.93e-05	4	119	2	18667791
Pubmed	Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.	AKR1C1 AKR1C2	6.93e-05	4	119	2	28259989
Pubmed	Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.	AKR1C1 AKR1C2	6.93e-05	4	119	2	21521174
Pubmed	Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	6.93e-05	4	119	2	8274401
Pubmed	Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.	AKR1C1 AKR1C2	6.93e-05	4	119	2	16511129
Pubmed	Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.	AKR1C1 AKR1C2	6.93e-05	4	119	2	10803568
Pubmed	AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.	AKR1C1 AKR1C2	6.93e-05	4	119	2	34590152
Pubmed	Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases.	PTPRC SYK	6.93e-05	4	119	2	21245479
Pubmed	Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.	AKR1C1 AKR1C2	6.93e-05	4	119	2	7789999
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	FLNC RBBP6 ZHX2 GPKOW SAFB AHNAK EIF3G SRRM2	7.24e-05	399	119	8	35987950
Pubmed	Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase.	FLNC LMCD1 DST	7.50e-05	24	119	3	19616115
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	RGPD4 EPPK1 HNRNPM AKAP12 GANAB UBR5 MTHFD1 AHNAK ECI2 TOP2A	8.01e-05	647	119	10	26618866
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	EPPK1 SMCHD1 UBE2O UBR5 SRRM2	8.15e-05	128	119	5	28027390
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RBBP6 HNRNPM SAFB GANAB NEMF SYK CPSF1 EIF3G SRRM2 TIMM44	8.64e-05	653	119	10	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNC EPPK1 SMCHD1 UBE2O GANAB DST UBR5 AHNAK CPSF1 SRRM2	8.64e-05	653	119	10	22586326
Interaction	SUMO2 interactions	ANKRD35 EPPK1 SMCHD1 HNRNPM UBA2 RNF213 SAFB DST MTHFD1 AHNAK RCOR3 SRRM2 TOP2A AHNAK2	2.35e-06	591	105	14	int:SUMO2
Interaction	NAA40 interactions	RBBP6 SMCHD1 HNRNPM HLCS TACC2 GPKOW NSRP1 AKAP12 UBE2O SAFB DST MTHFD1 AHNAK EIF4B NCOA7 EIF3G TOP2A AHNAK2	2.81e-06	978	105	18	int:NAA40
Interaction	ARHGEF35 interactions	ARHGEF5 OBSL1 ARHGEF35	1.13e-05	9	105	3	int:ARHGEF35
Interaction	FAM90A26 interactions	FAM90A1 FAM90A26	2.69e-05	2	105	2	int:FAM90A26
Interaction	SLFN11 interactions	BDP1 RBBP6 HNRNPM RNF213 EIF4B CPSF1 NUTM2F DNA2 SRRM2 TOP2A	2.71e-05	376	105	10	int:SLFN11
Interaction	FGF11 interactions	SETD1A EPPK1 SMCHD1 UBE2O UBR5 EIF4B SRRM2	3.05e-05	170	105	7	int:FGF11
Interaction	PINK1 interactions	FLNC EPPK1 DSG3 HNRNPM AKR1C2 UBE2O GANAB DST MTHFD1 AHNAK EIF4B SRRM2 AHNAK2	5.20e-05	679	105	13	int:PINK1
Interaction	CIT interactions	ANKRD35 GPRASP1 FLNC EPPK1 RBBP6 SMCHD1 HNRNPM OBSL1 RNF213 AKR1A1 SAFB GANAB INF2 AHNAK CPSF1 ECI2 SRRM2 TOP2A SLC39A7 AHNAK2	5.21e-05	1450	105	20	int:CIT
Interaction	ACTC1 interactions	RBBP6 HNRNPM OBSL1 WASHC2A GPKOW NSRP1 UBE2O DST INF2 MTHFD1 CPSF1 NUTM2F SRRM2	6.49e-05	694	105	13	int:ACTC1
Cytoband	8p23.1	FAM90A14 FAM90A2P FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	9.15e-15	154	119	12	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 FAM90A2P FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.36e-12	234	119	12	chr8p23
Cytoband	19p13.3-p13.2	HNRNPM SAFB TIMM44	6.05e-06	14	119	3	19p13.3-p13.2
Cytoband	10p15-p14	AKR1C1 AKR1C2	9.93e-05	6	119	2	10p15-p14
Cytoband	19p13.12	BRME1 NDUFB7 PALM3	3.04e-04	50	119	3	19p13.12
Cytoband	10q23.2	NUTM2A NUTM2D	8.83e-04	17	119	2	10q23.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q22	NUTM2G SYK BARX1 NUTM2F	1.88e-03	200	119	4	chr9q22
GeneFamily	Aldo-keto reductases	AKR1A1 AKR1C1 AKR1C2	2.05e-05	15	66	3	399
GeneFamily	G protein-coupled receptors, Class C orphans	GPR179 GPR158	2.72e-04	7	66	2	285
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 DST	3.62e-04	8	66	2	939
GeneFamily	RNA binding motif containing	SETD1A HNRNPM SAFB EIF4B EIF3G	1.08e-03	213	66	5	725
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	BDP1 RBBP6 NSRP1 AHNAK NEMF CEP152 SRRM2 TOP2A	2.84e-08	197	108	8	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 DSG3 ARHGEF5 AKR1C1 AKR1C2 ARHGEF35 DST NCOA7	2.95e-08	198	108	8	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 DSG3 ARHGEF5 AKR1C1 AKR1C2 ARHGEF35 NCOA7 AHNAK2	2.95e-08	198	108	8	22935a8afac54021f68b5f7a5accf51523e2f336
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRUNE2 FLNC SGSM1 LMCD1 ODAD1 TACC2 TNFRSF11A	3.61e-07	186	108	7	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 DSG3 ARHGEF5 AKR1C1 AKR1C2 ARHGEF35 NCOA7	5.32e-07	197	108	7	233b9fcb376e08d0080a05ca0198ecc6ec720f90
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPPK1 ARHGAP23 DSG3 AKR1C1 AKR1C2 TOP2A AHNAK2	5.32e-07	197	108	7	2430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 DSG3 UBA2 DST MTHFD1 AHNAK EIF4B	5.70e-07	199	108	7	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 FLNC AKAIN1 TNFRSF11A SYK MYO18B	3.71e-06	170	108	6	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB32 PTPRC CPSF1 CEP152 DNA2 TOP2A	4.38e-06	175	108	6	3bca1aac2a2a1f46753b5f9462888f144ed8327b
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	ACAP1 SMCHD1 RNF213 PTPRC UBR5 AHNAK	5.31e-06	181	108	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	AKAP6 FLNC XIRP1 LMCD1 TACC2 MYO18B	5.48e-06	182	108	6	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	AKAP6 FLNC XIRP1 TACC2 DST MYO18B	5.84e-06	184	108	6	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	AKAP6 PRUNE2 LMCD1 AKAP12 DST CDH11	6.40e-06	187	108	6	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 PRUNE2 FLNC INKA2 AKAP12 AHNAK2	6.40e-06	187	108	6	3912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PRUNE2 TNFRSF11A AKR1C1 AKAP12 AHNAK SLC24A1	7.45e-06	192	108	6	b016e229300c183e14c0e2bba494bf49c7899112
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TACC2 GALNT18 SLC38A10 DST SRRM2	7.45e-06	192	108	6	1304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PRUNE2 TNFRSF11A AKR1C1 AKAP12 AHNAK SLC24A1	7.45e-06	192	108	6	ac96831492c62ad9e1f7d0b764fbdf7d8a189ad9
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TACC2 GALNT18 SLC38A10 DST SRRM2	7.90e-06	194	108	6	92b39a935e8c577eb1123d706d168fa13cf3344c
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRUNE2 L1CAM NSRP1 AKAP12 DST TIMM44	7.90e-06	194	108	6	8985095f291c1b54e45f4edece49aa26e8c8b732
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 DSG3 ARHGEF5 AKR1C1 AKR1C2 AHNAK2	8.14e-06	195	108	6	24d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PRUNE2 FLNC AKR1C2 GALNT18 AHNAK AHNAK2	8.38e-06	196	108	6	24d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 AKAIN1 L1CAM AKR1C1 AKR1C2 NCOA7	8.38e-06	196	108	6	36b4f08fc038dfde6343ff0869e1a027d882adb5
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSG3 AKR1C1 AKR1C2 NCOA7 TOP2A AHNAK2	8.62e-06	197	108	6	1d4ccca2ff46fccb3ac052b5148cb7f94231d65a
ToppCell	3'-Broncho-tracheal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSG3 AKR1C1 AKR1C2 DST NCOA7 AHNAK2	8.62e-06	197	108	6	5d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 DSG3 AKR1C1 AKR1C2 NCOA7 AHNAK2	8.87e-06	198	108	6	89ec1e760a193441092571475cc66a3b425f232e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSG3 AKR1C1 AKR1C2 DST NCOA7 AHNAK2	8.87e-06	198	108	6	240e1aa0594ee6de530b2f97d5e392c5fcbf278b
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 DSG3 UBA2 DST AHNAK EIF4B	8.87e-06	198	108	6	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	3'-Broncho-tracheal-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSG3 AKR1C1 AKR1C2 DST NCOA7 AHNAK2	8.87e-06	198	108	6	aa6e7218ee6230902854e66c444b544218b30c0e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSG3 AKR1C1 AKR1C2 DST NCOA7 AHNAK2	8.87e-06	198	108	6	9a229167d4da4abf8c336dfe5cfdf57db756fc8b
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 DSG3 UBA2 DST AHNAK EIF4B	8.87e-06	198	108	6	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 AKR1C1 AKR1C2 DST NCOA7 TOP2A	9.13e-06	199	108	6	4099df3c052a9536d72ba01492317be7d83a79ad
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP23 DSG3 AKR1C1 AKR1C2 DST NCOA7	9.13e-06	199	108	6	c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BDP1 SMCHD1 RNF213 PTPRC AHNAK SRRM2	9.40e-06	200	108	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SMCHD1 RNF213 ZBTB32 PTPRC TOP2A	1.96e-05	135	108	5	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 FLNC XIRP1 AKAIN1 MYO18B	5.91e-05	170	108	5	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SETD1A DSG3 ARHGEF5 SAMD15 SYK	6.60e-05	174	108	5	59ccc5a82507463e0a316ba6286cb25ec1a4091b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BRME1 TNFRSF11A NUTM2G PTPRC TOP2A	6.78e-05	175	108	5	f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 FLNC XIRP1 LMCD1 MYO18B	6.96e-05	176	108	5	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP23 L1CAM AHNAK SLC45A2 DNA2	7.15e-05	177	108	5	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMCHD1 AKAP12 PTPRC AHNAK SYK	8.16e-05	182	108	5	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPKOW DSCAML1 ZBTB32 CRACDL TOP2A	8.16e-05	182	108	5	6c9a48037fa002bc528875538bdaaf15696d68b6
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNC TNFRSF11A AKR1C1 AKR1C2 AKAP12	8.37e-05	183	108	5	764ea07621f77fbd13a877aed5806ae2b3dfb43e
ToppCell	normal-na-Lymphocytic_T-CytoT_GZMK+-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	ACAP1 SMCHD1 RNF213 PTPRC NCOA7	8.37e-05	183	108	5	79defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	RBBP6 SMCHD1 RNF213 DST NCOA7	8.37e-05	183	108	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNC ARHGAP23 TNFRSF11A GALNT18 AKAP12	8.37e-05	183	108	5	bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell	(6)_Endothelial-F_(Lymphatics)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FLNC ARHGAP23 GALNT18 AKAP12 SLC24A1	8.59e-05	184	108	5	03ea613e00b45c81b752c14505a0538d698f551e
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNC C16orf96 TNFRSF11A AKAP12 SLC24A1	8.59e-05	184	108	5	1a4297b9d3cc4744bea0408fd5ee7b33ba2a1d78
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	AKAP6 FLNC XIRP1 TACC2 MYO18B	8.81e-05	185	108	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMCHD1 AKAP12 PTPRC AHNAK SYK	8.81e-05	185	108	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DSG3 AKR1A1 AKR1C2 AHNAK AHNAK2	8.81e-05	185	108	5	e0172e0ab0f1d7151a3c3c63bb7c84d6bda92035
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNC LMCD1 TACC2 GALNT18 AKAP12	8.81e-05	185	108	5	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	droplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC SGSM1 LMCD1 GALNT18 AKAP12	9.04e-05	186	108	5	f23f21781a758541f59c06efa7739d26a03fb478
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 AKAIN1 L1CAM AKR1C2 GPR158	9.04e-05	186	108	5	18fd311252299d6d30ddb32002ed069056108206
ToppCell	COVID_vent-Myeloid-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TNFRSF11A DST ARHGAP31 SYK SLC45A2	9.04e-05	186	108	5	63a5cdd3f60681762a218be32db84be8f29b88fd
ToppCell	COVID_vent-Myeloid-Dendritic-cDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TNFRSF11A DST ARHGAP31 SYK SLC45A2	9.04e-05	186	108	5	39457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC SGSM1 LMCD1 GALNT18 AKAP12	9.04e-05	186	108	5	0de87109da9324c597fadf2eb782f0f158afe832
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	FLNC SGSM1 ARHGAP23 GALNT18 AKAP12	9.27e-05	187	108	5	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLNC ARHGAP23 GALNT18 AKAP12 SLC24A1	9.50e-05	188	108	5	aa69e3f44d506f5ef358a3374ac5160d847c858f
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRUNE2 FLNC LMCD1 TACC2 GALNT18	9.50e-05	188	108	5	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	390C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLNC ARHGAP23 GALNT18 AKAP12 SLC24A1	9.50e-05	188	108	5	1f40b959777d18ad88d239df8cca304f062ba04c
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RNF213 ZBTB32 AHNAK SYK NCOA7	9.74e-05	189	108	5	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 FLNC LMCD1 ARHGEF5 TACC2	9.74e-05	189	108	5	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 FLNC LMCD1 ARHGEF5 TACC2	9.74e-05	189	108	5	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	AKAP6 FLNC XIRP1 TACC2 MYO18B	9.74e-05	189	108	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	AKAP6 FLNC XIRP1 TACC2 MYO18B	9.99e-05	190	108	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF5 AKR1C1 AKR1C2 ARHGEF35 PALM3	9.99e-05	190	108	5	b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNC TNFRSF11A AKR1C1 AKR1C2 SLC24A1	9.99e-05	190	108	5	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	(4)_Endothelial_cells-(40)_EC-arterial\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	FLNC LMCD1 L1CAM TACC2 AHNAK2	9.99e-05	190	108	5	ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF5 AKR1C1 AKR1C2 ARHGEF35 PALM3	9.99e-05	190	108	5	a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FLNC TNFRSF11A AKR1C1 AKR1C2 SLC24A1	9.99e-05	190	108	5	103e78c2233c3ee0c215a9dafe70705477e9ee5e
ToppCell	3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	XIRP1 LMCD1 AKR1C1 AKAP12 CDH11	1.02e-04	191	108	5	f5ce33af56178333730be308253943c54a0724cf
ToppCell	NS-critical-d_16-33-Epithelial-Secretory-diff\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	AKR1C1 AKR1C2 FER1L6 AHNAK PALM3	1.05e-04	192	108	5	02b11233b4da2d85b96498b3c6e22e3a31b3d049
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 PRUNE2 FLNC AKAP12 AHNAK2	1.07e-04	193	108	5	173f1d83133f5ffa88e2a75d28835ad7acd2aa90
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	CUX2 TNFRSF11A DST CRACDL SYK	1.07e-04	193	108	5	826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGAP23 LMCD1 AKAP12 ARHGAP31 NCOA7	1.07e-04	193	108	5	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	BL-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ARHGAP23 DSG3 AKR1C1 AKR1C2 DST	1.10e-04	194	108	5	2932f704656ca368565ec12f3452af3b18e8df12
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-Plasma_cell\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EMC7 AKR1A1 SLC38A10 ZBTB32 SLC39A7	1.10e-04	194	108	5	297286c57d7ee6338d9cf77b27eb2809378ce15d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 AKR1C1 AKR1C2 AKAP12 PALM3	1.10e-04	194	108	5	8ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	ANKRD35 GPRASP1 ARHGAP23 LMCD1 DST	1.13e-04	195	108	5	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPPK1 DSG3 AKR1C2 AHNAK AHNAK2	1.18e-04	197	108	5	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKAP6 PRUNE2 FLNC LMCD1 AKAP12	1.18e-04	197	108	5	3332b9b5bf78f0203ebbd94257a36e9054d896c3
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPPK1 DSG3 AKR1C2 AHNAK AHNAK2	1.18e-04	197	108	5	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	SMCHD1 PTPRC AHNAK EIF4B SRRM2	1.18e-04	197	108	5	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	Severe_COVID-19-Epithelial-transitional_Epi\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	EPPK1 AKR1C1 AKAP12 FER1L6 AHNAK2	1.18e-04	197	108	5	5ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EPPK1 AKR1C1 AKAP12 FER1L6 AHNAK2	1.18e-04	197	108	5	08b371309cd790b171ed76cabc7d910e71cd2835
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	EPPK1 AKR1C1 AKAP12 FER1L6 AHNAK2	1.18e-04	197	108	5	9f49feee38647bbf964974aac96fa75602186b5c
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKAP6 PRUNE2 FLNC AKAP12 STARD9	1.18e-04	197	108	5	ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKAP6 PRUNE2 FLNC LMCD1 AKAP12	1.21e-04	198	108	5	bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACAP1 DSG3 ARHGEF5 AKR1C1 AKR1C2	1.21e-04	198	108	5	3371276410dba693c238b383d990b89371b14d8d
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG3 DST MTHFD1 AHNAK EIF4B	1.21e-04	198	108	5	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	PSB-critical-LOC-Epithelial-Secretory\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COMTD1 AKR1C1 AKR1C2 FER1L6 SLC39A7	1.21e-04	198	108	5	e4cbe4032dba0da3fd46817ea9ad86ba9217f747
ToppCell	NS-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TACC2 AKR1C1 AKR1C2 FER1L6 PALM3	1.21e-04	198	108	5	4a481e1edb80b950c823ed926842cd5132cfb27f
ToppCell	5'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ARHGAP23 LMCD1 GALNT18 AKAP12 ARHGAP31	1.21e-04	198	108	5	90e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP23 DSG3 AKR1C2 TOP2A AHNAK2	1.21e-04	198	108	5	19d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCell	10x_5'_v1\|World / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACAP1 SMCHD1 RNF213 PTPRC AHNAK	1.24e-04	199	108	5	0478eafaa2a4819d1bbfb227e6c00d3578429bed
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CUX2 L1CAM FAM117B AKR1C1 AKR1C2	1.24e-04	199	108	5	a255484ba77bd2741a541da278efc8cf4abbe570
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPPK1 ARHGEF5 ARHGEF35 DST NCOA7	1.27e-04	200	108	5	41705bbba40eb5ddca0b223191aac1bce00163b8
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AKAP6 PRUNE2 FLNC LMCD1 AKAP12	1.27e-04	200	108	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Parenchyma_COVID-19-Epithelial-TX-Basal_3\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	EPPK1 ARHGEF5 ARHGEF35 DST NCOA7	1.27e-04	200	108	5	53e04399d0308b40ae99fbfaa4ff62bf061822d8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SMCHD1 RNF213 GALNT18 DST AHNAK	1.27e-04	200	108	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
Drug	o-quinone	DSG3 AKR1A1 AKR1C1 AKR1C2 SLC45A2	1.37e-06	41	107	5	CID000011421
Drug	9,10-phenanthrenequinone	AKR1A1 AKR1C1 AKR1C2 TOP2A	5.40e-06	25	107	4	ctd:C005399
Drug	4-hydroxybenzoic acid	HLCS AKR1C1 AKR1C2	8.30e-06	9	107	3	ctd:C038193
Drug	Dihydroxydihydrobenzopyrenes	AKR1A1 AKR1C1 AKR1C2	1.62e-05	11	107	3	ctd:D004101
Drug	fenamic acid	LMCD1 AKR1C1 AKR1C2	2.15e-05	12	107	3	ctd:C001209
Drug	(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE	AKR1C1 AKR1C2	2.19e-05	2	107	2	DB07768
Drug	4-formyl-benzoate	AKR1A1 AKR1C1 AKR1C2	2.79e-05	13	107	3	CID000012088
Drug	1-acenaphthenol	AKR1A1 AKR1C1 AKR1C2	3.54e-05	14	107	3	CID000022750
Drug	benzo(a)pyrene-1,6-quinone	AKR1A1 AKR1C1 AKR1C2	6.54e-05	17	107	3	ctd:C030233
Drug	cyclopentanone	AKR1C1 AKR1C2	6.54e-05	3	107	2	ctd:C007201
Drug	5-dihydrodeoxycorticosterone	AKR1C1 AKR1C2	6.54e-05	3	107	2	ctd:C454687
Drug	4-benzoylbenzoic acid	AKR1C1 AKR1C2	6.54e-05	3	107	2	ctd:C058818
Drug	cyclopentanol	AKR1C1 AKR1C2	6.54e-05	3	107	2	ctd:C016327
Drug	dichloro(4-cymene)ruthenium(II)	AKR1C1 AKR1C2	6.54e-05	3	107	2	ctd:C530610
Disease	Neoplasms, Hormone-Dependent	AKR1C1 AKR1C2	3.14e-05	3	96	2	C0027661
Disease	Ambiguous Genitalia	AKR1C1 AKR1C2	1.04e-04	5	96	2	C0266362
Disease	Pseudohermaphroditism	AKR1C1 AKR1C2	1.04e-04	5	96	2	C0033804
Disease	Endometrial Stromal Sarcoma	NUTM2A NUTM2B	1.04e-04	5	96	2	C0206630
Disease	Hermaphroditism	AKR1C1 AKR1C2	1.04e-04	5	96	2	C0019269
Disease	Intersex Conditions	AKR1C1 AKR1C2	1.04e-04	5	96	2	C2930618
Disease	Sex Differentiation Disorders	AKR1C1 AKR1C2	1.04e-04	5	96	2	C2930619
Disease	Clear cell sarcoma of kidney	NUTM2E NUTM2B	1.56e-04	6	96	2	C0334488
Disease	Disorders of Sex Development	AKR1C1 AKR1C2	2.18e-04	7	96	2	C0036875
Disease	cancer (implicated_via_orthology)	ACAP1 CUX2 RBBP6 DST DNA2 TOP2A	2.48e-04	268	96	6	DOID:162 (implicated_via_orthology)
Disease	X-Linked Csnb	GPR179 SLC24A1	6.77e-04	12	96	2	C3711543
Disease	Night blindness, congenital stationary, type 1	GPR179 SLC24A1	6.77e-04	12	96	2	C3501847
Disease	Night Blindness, Congenital Stationary, Type 1A	GPR179 SLC24A1	6.77e-04	12	96	2	C3495587
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder)	GPR179 SLC24A1	6.77e-04	12	96	2	C1864877
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A	GPR179 SLC24A1	6.77e-04	12	96	2	C1848172
Disease	cleft palate (is_implicated_in)	TBX22 MTHFD1	6.77e-04	12	96	2	DOID:674 (is_implicated_in)
Disease	NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B	GPR179 SLC24A1	6.77e-04	12	96	2	C1850362
Disease	hematologic cancer (implicated_via_orthology)	CUX2 UBA2	7.98e-04	13	96	2	DOID:2531 (implicated_via_orthology)
Disease	Cone-rod synaptic disorder, congenital nonprogressive	GPR179 SLC24A1	7.98e-04	13	96	2	C4041558
Disease	cutaneous melanoma, hair color	AKAP12 AHNAK SLC45A2	1.10e-03	62	96	3	EFO_0000389, EFO_0003924
Disease	response to methotrexate	AKR1C1 AKR1C2	1.22e-03	16	96	2	GO_0031427
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	UBR5 SYK	1.22e-03	16	96	2	C0334634
Disease	Sclerocystic Ovaries	ARHGAP23 AKR1C1 AKR1C2 TOP2A	1.28e-03	144	96	4	C1136382
Disease	Polycystic Ovary Syndrome	ARHGAP23 AKR1C1 AKR1C2 TOP2A	1.28e-03	144	96	4	C0032460
Disease	Night blindness, congenital stationary	GPR179 SLC24A1	1.38e-03	17	96	2	C0339535
Disease	chromosomal aberration frequency	UBR5 SYK	1.55e-03	18	96	2	EFO_0009860
Disease	Brugada syndrome	NCOA7 MYO18B	1.73e-03	19	96	2	MONDO_0015263
Disease	Seckel syndrome	CEP152 DNA2	2.32e-03	22	96	2	C0265202
Disease	Left ventricular mass to end-diastolic volume ratio	OBSL1 MYO18B	2.99e-03	25	96	2	EFO_0010556

Protein segments in the cluster

Peptide	Gene	Start	Entry
GEKPGNEPEEVKLQN	AKAIN1	6	P0CW23
KNGPEEVKPLGEVET	BDP1	941	A6H8Y1
KSQGLDVQEPPVKDG	CEP152	1551	O94986
GEKEKLPGELEPVQA	EIF3G	191	O75821
KKRPDGKQEQAPVED	AKAP12	816	Q02952
EKGVPVSGQEAKEPE	ARHGEF5	366	Q12774
EKGVPVSGQEAKEPE	ARHGEF35	366	A5YM69
EVPDVNIEGPEGKLK	AHNAK	916	Q09666
KGEGPDVDVNLPKAD	AHNAK	3036	Q09666
DVPDVNIEGPEGKLK	AHNAK	3061	Q09666
GPEVDIKGPKVDINA	AHNAK	3776	Q09666
KGEGPEVDVNLPKAD	AHNAK	3946	Q09666
KGEGPDVDVNLPKAD	AHNAK	4666	Q09666
TLPAQDGKKEARGPE	C19orf84	156	I3L1E1
KQKELGGEEPEPSLR	ACAP1	246	Q15027
DEEKEKRVPGARGEP	ANKRD35	581	Q8N283
QDSGELDKGQGPPKE	CUX2	1316	O14529
ANPGPLNKDKGEKEE	FAM90A10	91	A6NDY2
EGGIEEFKPPESNQK	RCOR3	271	Q9P2K3
GQEKGKEQERPPEAV	NSRP1	506	Q9H0G5
ANPGPLNKDKGEKEE	FAM90A7	91	A6NKC0
PIQDGGKSQEEPSKV	INTS10	526	Q9NVR2
EKEGPQPQEKPVGAL	PALM3	571	A6NDB9
QPQEKPVGALEEEGV	PALM3	576	A6NDB9
GEELKSNEPEGQVEP	OBSL1	651	O75147
LGVDGEGKEVQPPSK	DSG3	861	P32926
ANPGPLNKDKGEKEE	FAM90A23	91	A8MXZ1
EEENGKPVKSQGIPI	KDM7A	476	Q6ZMT4
GDVNVEKNETEPPKG	NEMF	426	O60524
PDIKGDQKENPGGQE	SLC24A1	731	O60721
GAREPKGEKGQPQEL	INKA2	186	Q9NTI7
EKPEGQIQKQEAVGP	GPR179	1636	Q6PRD1
ANPGPLNKDKGEKEE	FAM90A1	91	Q86YD7
KTPVLPERAKEENGG	GPR158	1091	Q5T848
QGVQPKTGPFEDLKE	SYK	111	P43405
SEQKPVGGDPKAIEI	DST	6401	Q03001
KENLEKPRSPGEVTG	KIAA2026	586	Q5HYC2
PKGEGERPAQNEKRK	HNRNPM	36	P52272
VGRDDPKALGEEPKQ	HLCS	61	P50747
QERAKDAEKPAEVPG	BARX1	231	Q9HBU1
PVRKEEEDNPKGEGT	CPSF1	541	Q10570
ANPGPLNKDKGEKEE	FAM90A22	91	A8MWA6
ANPGPLNKDKGEKEE	FAM90A14	91	P0C7W9
PKGTEEPVKVREAGD	FLNC	516	Q14315
EKDKEDQPQGLVPGG	GPKOW	231	Q92917
EAAPEKNPVDVKGEG	L1CAM	711	P32004
GTPKGVGPVKENDEI	FAHD1	191	Q6P587
GIPGVPGLEEDQKKN	PRDM12	211	Q9H4Q4
ANPGPLNKDKGEKEE	FAM90A17	91	P0DV74
ANPGPLNKDKGEKEE	FAM90A16	91	P0DV73
PDPDVLEKREKQAGE	ODAD1	236	Q96M63
EPGKQAKVPERGQEP	CRACDL	856	Q6NV74
AKVPERGQEPVKQAD	CRACDL	861	Q6NV74
ANPGPLNKDKGEKEE	FAM90A19	91	P0DV76
DGKPVRKGPGKQEEV	INF2	956	Q27J81
ELAKGQGPGEVDPKV	NDUFB7	121	P17568
GLPKEEGKQQEKPEG	LMCD1	206	Q9NZU5
KPAKGPQEKVDGERE	RBBP6	1036	Q7Z6E9
NRPGDKAEAPKGQEQ	PRICKLE4	271	Q2TBC4
ANPGPLNKDKGEKEE	FAM90A8	91	A6NJQ4
PKAEKRQIGDQEGPR	FBF1	221	Q8TES7
KPETDRVPGDGGQKE	BRME1	221	Q0VDD7
DRVGKDGAPKEAQPK	C16orf96	541	A6NNT2
IPPIKSAQGEGDDVK	DSCAML1	1576	Q8TD84
GEKEEQLIPQDIPDG	FAM117B	361	Q6P1L5
RGKVLQPPKGDVAAE	COMTD1	216	Q86VU5
VRGQEPAPDKKLEED	GALNT18	41	Q6P9A2
AVPGEEVGRVKAKDP	CDH11	281	P55287
PGNKGREFVPDEQKQ	MS4A14	221	Q96JA4
TDIPPGGVEEKAKNN	ECI2	206	O75521
KIEGRAVVPGVKPQD	EMC7	46	Q9NPA0
LNPKEPGKRDGEGQE	CCDC168	4371	Q8NDH2
GEGVQESKKEPGVVP	CCDC168	4926	Q8NDH2
ANPGPLNKDKGEKEE	FAM90A20P	91	A6NIJ5
NTDKVPAPEQVEKGG	DNA2	896	P51530
ANPGPLNKDKGEKEE	FAM90A5P	91	A8MXJ8
EGEPDSAKNVQLKPG	SAMD15	66	Q9P1V8
REEEKERQQAPGGDP	SLC45A2	451	Q9UMX9
QAQIKGPVDVPGRED	SLC38A10	456	Q9HBR0
VPDDKKPNGRKVVGD	MTHFD1	241	P11586
ANPGPLNKDKGEKEE	FAM90A24P	91	P0C7X0
QPSEEGPGRKDENKV	EIF4B	516	P23588
GEPEKQREEGEVKQP	NUTM2A	536	Q8IVF1
GEPEKQREEGKVKQP	NUTM2B	536	A6NNL0
PEKQREEGEVKQPQE	NUTM2D	466	Q5VT03
GEPEKQREEGKVKQP	NUTM2E	536	B1AL46
PEGQREKGKVEQPQE	NUTM2F	416	A1L443
PEGQREKGKVEQPQE	NUTM2G	401	Q5VZR2
KKPGEEVVGGAEIEN	GPRASP1	16	Q5JY77
EEAEKNPVGKARKEP	FER1L6	1776	Q2WGJ9
GISEPGNQEKESEKP	RGPD4	926	Q7Z3J3
GPKGNEIRTSKEVEP	SMCHD1	356	A6NHR9
KDVNPGGKEETPGQR	SRRM2	101	Q9UQ35
PKEDQNGLVDPKTRG	PRUNE2	896	Q8WUY3
ANEKAPVEGIGQPEK	SPRYD4	136	Q8WW59
QAGDPITEGNKEPDK	NCOA7	566	Q8NI08
ANPGPLNKDKGEKEE	FAM90A12P	91	A8MX19
PEETQGKAEKDEPGA	GANAB	211	Q14697
ANPGPLNKDKGEKEE	FAM90A9	91	A6NNJ1
ANPGPLNKDKGEKEE	FAM90A13P	91	P0C7W8
ANPGPLNKDKGEKEE	FAM90A26	91	D6RGX4
GVLVPAKDQPGRQEK	EPPK1	4896	P58107
VVGDAPEKVGPKQAE	UBA2	546	Q9UBT2
GDVPGVPQKREAEET	STARD9	3776	Q9P2P6
QDKPEVDKGEGQLPE	MRGPRX4	296	Q96LA9
EQEKEAGEPGRPGTK	SETD1A	926	O15047
ANPGPLNKDKGEKEE	FAM90A15P	91	P0C7V4
KGRKPEEEGVEDNGL	SAFB	91	Q15424
AVVKREPAEQPGDGE	SAFB	291	Q15424
NGNIEGIPERQKGKP	AKAP6	1896	Q13023
EVQAGQVDVKLPEGP	AHNAK2	891	Q8IVF2
EVQAGQVDVKLPEGP	AHNAK2	1551	Q8IVF2
EVQAGQVDVKLPEGP	AHNAK2	2376	Q8IVF2
EVQAGQVDVKLPEGP	AHNAK2	2541	Q8IVF2
EVQAGQVDVKLPEGP	AHNAK2	4026	Q8IVF2
EVQAGQVDVKLPEGP	AHNAK2	4191	Q8IVF2
EVQAGQEDVKLPEGP	AHNAK2	4356	Q8IVF2
KEDVGPGKAVPREEL	AKR1A1	61	P14550
SVKPGEEVIPKDENG	AKR1C1	121	Q04828
SVKPGEEVIPKDENG	AKR1C2	121	P52895
NEQGEPEDLKKPEGK	RNF213	331	Q63HN8
PKDGPVRPQNAEEEK	SLC39A7	296	Q92504
DPIQAEQPELREKKG	TBX22	26	Q9Y458
EDKGERTPVGDKEPQ	ARHGAP23	1101	Q9P227
ANPGPLNKDKGEKEE	FAM90A2P	91	Q658T7
AVPDVERKEDKPEGQ	UBE2O	881	Q9C0C9
PSAGRERQPKEEGQK	TACC2	171	O95359
ELEKRPNPEKVVEEG	ARHGAP31	601	Q2M1Z3
PNPEKVVEEGREAGE	ARHGAP31	606	Q2M1Z3
EAEGRLEEKQPKIPN	SGSM1	741	Q2NKQ1
RKENQDGPAPQEEGK	MYO18B	481	Q8IUG5
VEAKEKQDEQVGLPG	TOP2A	1181	P11388
EVDRAKEKGIGTPQP	ZHX2	26	Q9Y6X8
VRNPKGEVVEGDPDK	TIMM44	401	O43615
IIQAPQKEVGKGRDP	WASHC2A	816	Q641Q2
RNPERELGDPGEKQK	ZBTB32	136	Q9Y2Y4
ELGDPGEKQKPEQVS	ZBTB32	141	Q9Y2Y4
PVPTLGKGGQEAEEK	VRTN	561	Q9H8Y1
GAPEKLPEAKEQAEG	PTPRC	1266	P08575
QKEEGKSQGDPQPEA	XIRP1	571	Q702N8
NRQKKEGEEQPVLPE	UBR5	2116	O95071
PEKASRPVQEQGGAK	TNFRSF11A	601	Q9Y6Q6
ANPGPLNKDKGEKEE	FAM90A18	91	P0DV75