Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

NUP98 BCL9L CREBBP NCOA6 MAML2

7.60e-06303195GO:0003713
GeneOntologyMolecularFunctiontranscription coregulator activity

NUP98 BCL9L CREBBP NCOA6 PRDM8 MAML2

9.61e-06562196GO:0003712
GeneOntologyMolecularFunctionSMAD binding

CREBBP USP9X SMAD4

7.11e-0586193GO:0046332
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

CREBBP NCOA6

1.78e-0421192GO:0042975
GeneOntologyMolecularFunctionchromatin binding

NUP98 CREBBP NCOA6 PRDM8 SMAD4

5.17e-04739195GO:0003682
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

NUP98 BCL9L CREBBP NCOA6 PRDM8 MAML2

5.34e-041160196GO:0030674
GeneOntologyMolecularFunctiontranscription coactivator binding

CREBBP SMAD4

1.19e-0354192GO:0001223
GeneOntologyMolecularFunctionmolecular adaptor activity

NUP98 BCL9L CREBBP NCOA6 PRDM8 MAML2

1.22e-031356196GO:0060090
GeneOntologyMolecularFunctionhistone modifying activity

CREBBP PRDM8 RPS6KA4

1.26e-03229193GO:0140993
GeneOntologyMolecularFunctioncollagen binding

COL5A3 SMAD4

2.66e-0381192GO:0005518
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

BCL9L CREBBP USP9X SMPD3 SMAD4

3.10e-05445185GO:0141091
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

BCL9L CREBBP USP9X SMPD3 SMAD4

4.55e-05482185GO:0007178
GeneOntologyBiologicalProcesssomite rostral/caudal axis specification

MESP2 SMAD4

6.51e-0514182GO:0032525
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

BCL9L CREBBP USP9X SMAD4

8.28e-05276184GO:0007179
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

BCL9L CREBBP NCOA6 MESP2 MAML2 SMAD4 RPS6KA4

1.02e-041390187GO:0045944
GeneOntologyBiologicalProcesspositive regulation of CREB transcription factor activity

CREBBP RPS6KA4

1.09e-0418182GO:0032793
GeneOntologyBiologicalProcessembryo development

CREBBP NCOA6 USP9X MESP2 SMAD4 STRCP1 STRC

1.26e-041437187GO:0009790
GeneOntologyBiologicalProcessneuron development

MTCH1 CREBBP USP9X PRDM8 SMAD4 STRCP1 STRC

1.41e-041463187GO:0048666
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

BCL9L CREBBP USP9X SMAD4

1.77e-04336184GO:0071560
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of sound

STRCP1 STRC

1.80e-0423182GO:0050910
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

BCL9L CREBBP USP9X SMAD4

1.91e-04343184GO:0071559
GeneOntologyBiologicalProcessauditory receptor cell stereocilium organization

STRCP1 STRC

2.31e-0426182GO:0060088
GeneOntologyBiologicalProcessembryonic morphogenesis

CREBBP MESP2 SMAD4 STRCP1 STRC

2.87e-04713185GO:0048598
GeneOntologyBiologicalProcessauditory receptor cell morphogenesis

STRCP1 STRC

3.29e-0431182GO:0002093
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

USP9X PRDM8 SMAD4 STRCP1 STRC

3.58e-04748185GO:0048667
GeneOntologyBiologicalProcesscell morphogenesis

BCL9L USP9X PRDM8 SMAD4 STRCP1 STRC

3.77e-041194186GO:0000902
GeneOntologyBiologicalProcesspositive regulation of cellular response to transforming growth factor beta stimulus

CREBBP SMAD4

4.21e-0435182GO:1903846
GeneOntologyBiologicalProcesspositive regulation of transforming growth factor beta receptor signaling pathway

CREBBP SMAD4

4.21e-0435182GO:0030511
GeneOntologyBiologicalProcessauditory receptor cell development

STRCP1 STRC

5.50e-0440182GO:0060117
GeneOntologyBiologicalProcessneuron projection development

CREBBP USP9X PRDM8 SMAD4 STRCP1 STRC

5.60e-041285186GO:0031175
GeneOntologyBiologicalProcessregulation of transforming growth factor beta receptor signaling pathway

BCL9L CREBBP SMAD4

5.85e-04192183GO:0017015
GeneOntologyBiologicalProcessregulation of cellular response to transforming growth factor beta stimulus

BCL9L CREBBP SMAD4

6.11e-04195183GO:1903844
GeneOntologyBiologicalProcessBMP signaling pathway

USP9X SMPD3 SMAD4

6.30e-04197183GO:0030509
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

BCL9L CREBBP USP9X SMPD3 SMAD4

6.43e-04850185GO:0071363
GeneOntologyBiologicalProcessresponse to growth factor

BCL9L CREBBP USP9X SMPD3 SMAD4

7.64e-04883185GO:0070848
GeneOntologyBiologicalProcessresponse to BMP

USP9X SMPD3 SMAD4

8.12e-04215183GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

USP9X SMPD3 SMAD4

8.12e-04215183GO:0071773
GeneOntologyBiologicalProcessestablishment of protein localization to organelle

NUP98 MTCH1 USP9X AGAP3

8.90e-04515184GO:0072594
GeneOntologyBiologicalProcesshead development

CREBBP NCOA6 USP9X OTP PRDM8

9.16e-04919185GO:0060322
GeneOntologyBiologicalProcessembryonic axis specification

MESP2 SMAD4

9.29e-0452182GO:0000578
GeneOntologyBiologicalProcessinner ear receptor cell stereocilium organization

STRCP1 STRC

9.65e-0453182GO:0060122
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

STRCP1 STRC

1.12e-0357182GO:0050974
GeneOntologyBiologicalProcessextracellular matrix assembly

SMPD3 SMAD4

1.19e-0359182GO:0085029
GeneOntologyBiologicalProcesspositive regulation of epithelial to mesenchymal transition

BCL9L SMAD4

1.36e-0363182GO:0010718
GeneOntologyBiologicalProcessinner ear auditory receptor cell differentiation

STRCP1 STRC

1.54e-0367182GO:0042491
GeneOntologyBiologicalProcesscell-matrix adhesion

COL5A3 STRCP1 STRC

1.56e-03270183GO:0007160
GeneOntologyBiologicalProcessanterior/posterior axis specification

MESP2 SMAD4

1.58e-0368182GO:0009948
GeneOntologyBiologicalProcesspositive regulation of non-canonical NF-kappaB signal transduction

CREBBP SMPD3

1.77e-0372182GO:1901224
GeneOntologyBiologicalProcessinner ear receptor cell development

STRCP1 STRC

1.82e-0373182GO:0060119
GeneOntologyBiologicalProcessembryonic digit morphogenesis

CREBBP SMAD4

1.87e-0374182GO:0042733
GeneOntologyBiologicalProcessdetection of mechanical stimulus

STRCP1 STRC

1.92e-0375182GO:0050982
GeneOntologyBiologicalProcessprotein localization to organelle

NUP98 MTCH1 CREBBP USP9X AGAP3

1.97e-031091185GO:0033365
GeneOntologyBiologicalProcesssomitogenesis

MESP2 SMAD4

1.97e-0376182GO:0001756
GeneOntologyBiologicalProcesshair cell differentiation

STRCP1 STRC

2.08e-0378182GO:0035315
GeneOntologyBiologicalProcessembryonic pattern specification

MESP2 SMAD4

2.81e-0391182GO:0009880
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

BCL9L CREBBP USP9X SMPD3 SMAD4

2.85e-031186185GO:0007167
GeneOntologyBiologicalProcesssomite development

MESP2 SMAD4

3.00e-0394182GO:0061053
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

STRCP1 STRC

3.12e-0396182GO:0060113
GeneOntologyBiologicalProcesscellular response to UV

CREBBP AGAP3

3.19e-0397182GO:0034644
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

BCL9L CREBBP SMAD4

3.19e-03347183GO:0090092
GeneOntologyBiologicalProcessintracellular protein transport

NUP98 MTCH1 USP9X AGAP3

3.36e-03740184GO:0006886
GeneOntologyBiologicalProcessprotein localization to nucleus

NUP98 CREBBP AGAP3

3.60e-03362183GO:0034504
GeneOntologyBiologicalProcessmechanoreceptor differentiation

STRCP1 STRC

3.65e-03104182GO:0042490
GeneOntologyCellularComponent9+2 non-motile cilium

STRCP1 STRC

7.08e-0514192GO:0097732
GeneOntologyCellularComponentkinocilium

STRCP1 STRC

7.08e-0514192GO:0060091
GeneOntologyCellularComponentnuclear body

NUP98 CREBBP OTP PRDM8 MAML2 AGAP3

1.07e-04903196GO:0016604
GeneOntologyCellularComponentstereocilium tip

STRCP1 STRC

1.79e-0422192GO:0032426
GeneOntologyCellularComponentnuclear protein-containing complex

NUP98 BCL9L CREBBP NCOA6 PRDM8 SMAD4

1.04e-031377196GO:0140513
GeneOntologyCellularComponentstereocilium

STRCP1 STRC

1.77e-0369192GO:0032420
GeneOntologyCellularComponenttranscription regulator complex

BCL9L CREBBP NCOA6 SMAD4

1.80e-03596194GO:0005667
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

BCL9L CREBBP SMAD4

1.81e-03272193GO:0090575
GeneOntologyCellularComponenthistone methyltransferase complex

NCOA6 PRDM8

2.09e-0375192GO:0035097
GeneOntologyCellularComponentstereocilium bundle

STRCP1 STRC

2.31e-0379192GO:0032421
GeneOntologyCellularComponentmethyltransferase complex

NCOA6 PRDM8

4.27e-03108192GO:0034708
GeneOntologyCellularComponentPML body

CREBBP AGAP3

5.68e-03125192GO:0016605
GeneOntologyCellularComponentfibrillar center

BCL9L OTP

8.71e-03156192GO:0001650
GeneOntologyCellularComponentkinetochore

NUP98 CREBBP

1.16e-02181192GO:0000776
GeneOntologyCellularComponentcondensed chromosome, centromeric region

NUP98 CREBBP

1.31e-02193192GO:0000779
GeneOntologyCellularComponentnon-motile cilium

STRCP1 STRC

1.35e-02196192GO:0097730
MousePhenodecreased embryo size

NUP98 BCL9L CREBBP NCOA6 USP9X MESP2 SMAD4

2.32e-06659157MP:0001698
MousePhenoabnormal embryo size

NUP98 BCL9L CREBBP NCOA6 USP9X MESP2 SMAD4

2.71e-05956157MP:0001697
MousePhenoabnormal prenatal growth/weight/body size

NUP98 BCL9L CREBBP NCOA6 USP9X MESP2 SMPD3 SMAD4

5.36e-051493158MP:0004196
MousePhenoabnormal prenatal body size

NUP98 BCL9L CREBBP NCOA6 USP9X MESP2 SMAD4

7.37e-051116157MP:0010866
MousePhenoabnormal neurohypophysis morphology

OTP SMPD3

1.63e-0418152MP:0004164
MousePhenoabnormal cochlear microphonics

STRCP1 STRC

1.63e-0418152MP:0004412
MousePhenoabnormal cochlear potential

STRCP1 STRC

1.82e-0419152MP:0006332
MousePhenoabnormal embryonic growth/weight/body size

NUP98 BCL9L CREBBP NCOA6 USP9X MESP2 SMAD4

1.90e-041295157MP:0002088
MousePhenoabnormal embryo development

NUP98 BCL9L CREBBP NCOA6 USP9X MESP2 SMAD4

2.71e-041370157MP:0001672
MousePhenoabnormal cochlear outer hair cell physiology

STRCP1 STRC

4.00e-0428152MP:0004434
MousePhenoabnormal secretory circumventricular organ morphology

OTP SMPD3

4.29e-0429152MP:0013563
MousePhenoabnormal circumventricular organ morphology

OTP SMPD3

4.91e-0431152MP:0013562
PathwayREACTOME_GASTRULATION

CREBBP MESP2 MAML2 SMAD4

1.12e-05129164M46433
PathwayREACTOME_FORMATION_OF_PARAXIAL_MESODERM

CREBBP MESP2 MAML2

6.00e-0569163M46439
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

CREBBP COL5A3 NCOA6 RPTN MESP2 MAML2 SMAD4 RPS6KA4

6.77e-051432168M509
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP MAML2

1.09e-0414162M27808
PathwayWP_RUBINSTEINTAYBI_SYNDROME_1

CREBBP SMAD4

1.26e-0415162M48323
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP MAML2

1.44e-0416162M27121
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3

CREBBP MAML2 SMAD4

1.61e-0496163M27784
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP SMAD4

1.63e-0417162MM1509
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP NCOA6

1.83e-0418162M26942
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP SMAD4

2.04e-0419162M18933
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP MAML2

2.27e-0420162M27881
PathwayREACTOME_ADIPOGENESIS

CREBBP NCOA6 SMAD4

2.40e-04110163M48259
PathwayWP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX

CREBBP SMAD4

2.50e-0421162M39593
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP SMAD4

2.75e-0422162MM1443
PathwayBIOCARTA_WNT_PATHWAY

CREBBP SMAD4

3.01e-0423162MM1527
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP SMAD4

3.01e-0423162M2821
PathwayBIOCARTA_WNT_PATHWAY

CREBBP SMAD4

3.29e-0424162M16517
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

USP9X SMAD4

3.29e-0424162MM14877
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP MAML2

3.57e-0425162M27880
PathwayREACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION

CREBBP NCOA6

4.17e-0427162M26943
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

CREBBP MAML2

4.49e-0428162M6177
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

USP9X SMAD4

5.51e-0431162M669
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

USP9X SMAD4

9.65e-0441162MM14876
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

CREBBP MAML2

1.01e-0342162M17541
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

CREBBP NCOA6

1.01e-0342162M27172
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

CREBBP MAML2

1.27e-0347162M7946
PathwayPID_HES_HEY_PATHWAY

CREBBP MAML2

1.32e-0348162M288
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP MAML2

1.32e-0348162M611
PathwayREACTOME_HEME_SIGNALING

CREBBP NCOA6

1.38e-0349162M41832
PathwayREACTOME_SIGNALING_BY_NOTCH3

CREBBP MAML2

1.38e-0349162M618
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

USP9X SMAD4

1.49e-0351162M665
PathwayWP_TGFBETA_SIGNALING_PATHWAY

CREBBP SMAD4

1.61e-0353162MM15880
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

CREBBP SMAD4

1.73e-0355162M39351
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS

CREBBP NCOA6

1.73e-0355162M27145
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

CREBBP NCOA6

1.73e-0355162M27001
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

CREBBP MAML2

1.92e-0358162M29616
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

CREBBP SMAD4

1.99e-0359162M39886
PathwayREACTOME_CYTOPROTECTION_BY_HMOX1

CREBBP NCOA6

2.06e-0360162M41830
PathwayPID_HIF1_TFPATHWAY

CREBBP SMAD4

2.48e-0366162M255
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION

CREBBP SMAD4

2.48e-0366162M27938
PathwayREACTOME_CIRCADIAN_CLOCK

CREBBP NCOA6

2.79e-0370162M938
PathwayKEGG_ADHERENS_JUNCTION

CREBBP SMAD4

3.03e-0373162M638
PathwayREACTOME_SIGNALING_BY_NOTCH1

CREBBP MAML2

3.11e-0374162M616
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3

MAML2 SMAD4

3.28e-0376162MM15520
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

USP9X SMAD4

3.36e-0377162MM14670
PathwayPID_MYC_ACTIV_PATHWAY

CREBBP SMAD4

3.54e-0379162M66
PathwayREACTOME_SIGNALING_BY_NOTCH4

CREBBP MAML2

3.80e-0382162M594
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

MAML2 SMAD4

3.80e-0382162MM15922
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

CREBBP SMAD4

3.80e-0382162M2
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

CREBBP NCOA6

3.99e-0384162M1008
PathwayKEGG_TGF_BETA_SIGNALING_PATHWAY

CREBBP SMAD4

4.18e-0386162M2642
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9L CREBBP

4.66e-0391162M27101
PathwayWP_ANDROGEN_RECEPTOR_SIGNALING

CREBBP SMAD4

4.66e-0391162M39700
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRCP1 STRC

3.14e-07220234910522
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRCP1 STRC

3.14e-07220211687802
Pubmed

Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock.

CREBBP NCOA6

9.42e-07320214960326
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRCP1 STRC

9.42e-07320230801007
Pubmed

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity.

NUP98 CREBBP

9.42e-0732029858599
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

STRCP1 STRC

1.88e-06420218849963
Pubmed

Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation.

CREBBP SMAD4

1.88e-06420212857787
Pubmed

Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats.

NUP98 CREBBP

1.88e-06420216651408
Pubmed

Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.

CREBBP NCOA6

3.14e-06520211912212
Pubmed

Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis.

USP9X SMAD4

3.14e-06520228115363
Pubmed

Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling.

CREBBP SMAD4

3.14e-06520217283070
Pubmed

The Kaposi's sarcoma-associated herpesvirus K-bZIP protein represses transforming growth factor beta signaling through interaction with CREB-binding protein.

CREBBP SMAD4

3.14e-06520215467747
Pubmed

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300.

CREBBP SMAD4

3.14e-0652029679056
Pubmed

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.

BCL9L SMAD4

3.14e-06520219328798
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

STRCP1 STRC

3.14e-06520224920589
Pubmed

Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.

CREBBP NCOA6

4.71e-06620215150259
Pubmed

A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

CREBBP SMAD4

4.71e-06620210887155
Pubmed

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

USP9X SMAD4

4.71e-06620219135894
Pubmed

Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.

CREBBP SMAD4

4.71e-06620215849193
Pubmed

Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.

CREBBP MAML2

4.71e-06620215961999
Pubmed

Functional interaction between Smad, CREB binding protein, and p68 RNA helicase.

CREBBP SMAD4

6.59e-06720215464984
Pubmed

Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses.

CREBBP SMAD4

6.59e-06720225514493
Pubmed

Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.

CREBBP NCOA6

8.78e-06820218552123
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

STRCP1 STRC

8.78e-06820221165971
Pubmed

CREB is a regulatory target for the protein kinase Akt/PKB.

CREBBP RPS6KA4

8.78e-0682029829964
Pubmed

Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3).

CREBBP SMAD4

8.78e-06820214691252
Pubmed

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.

CREBBP SMAD4

1.41e-051020216751102
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

STRCP1 STRC

1.72e-051120231776257
Pubmed

Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.

STRCP1 STRC

1.72e-051120231448880
Pubmed

A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein.

CREBBP NCOA6

2.07e-051220210866662
Pubmed

Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.

CREBBP NCOA6

2.07e-051220211158331
Pubmed

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

CREBBP NCOA6

2.07e-051220212189208
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

CREBBP NCOA6

2.85e-051420212482968
Pubmed

A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

CREBBP NCOA6

3.28e-051520210567404
Pubmed

Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.

CREBBP NCOA6

4.25e-051720228291835
Pubmed

Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.

STRCP1 STRC

4.25e-051720220856818
Pubmed

Interaction network of human early embryonic transcription factors.

NUP98 BCL9L CREBBP NCOA6

4.35e-0535120438297188
Pubmed

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation.

MESP2 SMAD4

5.34e-051920221822279
Pubmed

Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.

CREBBP NCOA6

5.34e-051920222982455
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

CREBBP NCOA6

5.93e-052020211877444
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

CREBBP NCOA6

6.55e-052120219596656
Pubmed

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.

RPTN SMPD3

7.21e-052220216949565
Pubmed

Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.

OTP PRDM8

7.21e-052220238160393
Pubmed

Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation.

RPTN SMPD3

8.61e-052420227208706
Pubmed

Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.

CREBBP SMAD4

1.01e-042620217177285
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NUP98 BCL9L CREBBP NCOA6

1.21e-0445720432344865
Pubmed

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

BCL9L CREBBP

1.74e-043420230894540
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

NUP98 CREBBP USP9X AGAP3

2.17e-0453320425544563
Pubmed

A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.

STRCP1 STRC

2.18e-043820238346162
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

NCOA6 SMAD4

3.49e-044820227703004
Pubmed

Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis.

BCL9L SMAD4

4.25e-045320224982181
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

BCL9L CREBBP NCOA6

4.68e-0426820333640491
InteractionNUAK2 interactions

USP9X SMAD4 AGAP3

1.91e-0556193int:NUAK2
InteractionPDE6D interactions

NCOA6 OTP SMAD4

3.13e-0566193int:PDE6D
InteractionPBX1 interactions

CREBBP USP9X SMAD4

6.68e-0585193int:PBX1
InteractionSMAD1 interactions

CREBBP NCOA6 USP9X SMAD4

6.93e-05243194int:SMAD1
InteractionMAML2 interactions

CREBBP MAML2

1.14e-0417192int:MAML2
InteractionKDM6B interactions

CREBBP USP9X SMAD4

1.22e-04104193int:KDM6B
InteractionNOTCH4 interactions

MAML2 SMAD4

1.75e-0421192int:NOTCH4
InteractionCREBBP interactions

NUP98 CREBBP NCOA6 MAML2 SMAD4

1.88e-04599195int:CREBBP
Cytoband15q15.3

STRCP1 STRC

5.38e-052520215q15.3
CytobandEnsembl 112 genes in cytogenetic band chr15q15

STRCP1 STRC

1.86e-03147202chr15q15
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nfib-Inhibitory_Neuron.Gad1Gad2.Nfib-Satb1_(Supramammillary_Nucleus_(SuM))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

OTP MESP2 STRC

3.38e-0666203f7d1d272ae723d8100b8c252b3d894dae5297fe4
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nfib|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

OTP MESP2 STRC

3.38e-06662032180e189dad1347ad77733ea95a934d70be97ee4
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Nfib-Inhibitory_Neuron.Gad1Gad2.Nfib-Satb1_(Supramammillary_Nucleus_(SuM))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

OTP MESP2 STRC

3.38e-0666203412c95c708344fd1726351389bb8a3d376f54fe4
ToppCelldroplet-Bladder-nan-24m-Epithelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3 KCNA6

6.72e-051792033d6bb3cfe89d60f2f00aead9341f9967e5313763
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3 KCNA6

7.41e-05185203ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL5A3 SMPD3 KCNA6

7.65e-051872038e8b147258982b359447add5027318f5b6d51963
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-mesenchymal_stem_cell_of_adipose|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8 SMPD3

7.77e-05188203e54e09d34e263d5709c337914809e61e74e20591
ToppCelldroplet-Fat-Scat-21m-Mesenchymal|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8 SMPD3

7.77e-051882037fc9810ab14354cb512e2b1285562009c10203f5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron|GW26 / Sample Type, Dataset, Time_group, and Cell type.

PRDM8 SMPD3 AGAP3

9.33e-052002035b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))-|Thalamus / BrainAtlas - Mouse McCarroll V32

OTP MESP2

8.01e-0494202be1dcfe287f58d608ccdb47cf9c1d12b5e3aa60d
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6|Thalamus / BrainAtlas - Mouse McCarroll V32

OTP MESP2

8.01e-0494202576c37fa53fab679f5e8786f5c798e18998186e9
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Slc17a6-Inhibitory_Neuron.Slc17a6-Gad1Gad2.Asb4_(Periventricular_Fiber_System_(Pv))|Thalamus / BrainAtlas - Mouse McCarroll V32

OTP MESP2

8.01e-049420282e9178c848468497295c4cc59c662b9279208a1
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PRDM8 STRC

1.09e-031102023639fb5fc02eca509cb220295bc3e6064c23baab
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.Zbtb20_(Ventral_Hippocampus)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PRDM8 STRC

1.09e-03110202ff196c71aa2a21cdd812958bd163fa6b91bd2352
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.Zbtb20_(Ventral_Hippocampus)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PRDM8 STRC

1.09e-0311020246635a130453c2fa304f0e09561b2a267c9ceb31
ToppCellEntopeduncular-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PRDM8 STRC

1.09e-03110202438bf761ab0a25e3dc9244c23ae2c2d68a169c7f
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MESP2 STRC

1.21e-03116202685484ea4cbefb5aff5f0cd999fdfadc5a5676e1
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MESP2 STRC

1.21e-031162021bfd3b0ec4cb5a04c6dfe7861a544eb277e473a3
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MESP2 STRC

1.21e-03116202a3dcd18807d14e207438f321be62797384fd3907
ToppCell(05)_Ciliated-(2)_48hpi|(05)_Ciliated / shred by cell type and Timepoint

RPS6KA4 STRC

1.39e-03124202fc8cce8c1809edafbc4e69e501dd4f016f5dfc0b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRDM8 SMPD3

1.86e-03144202f501e11b1d051ca67124137017a79a2d5bb6ae87
ToppCellBronchial_Biopsy-Epithelial-Goblet_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

RPTN C1orf167

1.89e-03145202e932361734839c14ffa0c1e028dcef9c833f884f
ToppCellBronchial_Biopsy-Epithelial-Goblet_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

RPTN C1orf167

1.91e-03146202a4f2e3ea79e7154873c01739672ec6454547e6a6
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

SMPD3 AGAP3

1.94e-031472028f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell(07)_Ionocytes-(1)_GFP|(07)_Ionocytes / shred by cell type by condition

STRC KCNA6

1.94e-03147202d398f49553ece2786c51e16e4bee028fb3833149
ToppCellP15-Epithelial-epithelial_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL5A3 KCNA6

2.07e-0315220200d5503d462cfa009fb4cac79ecee11725a18b9a
ToppCell356C-Myeloid-Dendritic-pDC|356C / Donor, Lineage, Cell class and subclass (all cells)

SMPD3 RPS6KA4

2.18e-03156202d9d87368e43b24952e70f31f38425e15b716ff5b
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL5A3 STRC

2.23e-031582027f5426585d0d299d2b48e5fcb349950feffdef33
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1|E18.5-samps / Age Group, Lineage, Cell class and subclass

BCL9L NCOA6

2.26e-03159202b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A3 SMPD3

2.26e-031592022607b562903228274fbd96168ba826782fab0b53
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A3 SMPD3

2.26e-03159202e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SMPD3 RPS6KA4

2.29e-0316020261f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SMPD3 RPS6KA4

2.29e-0316020234b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMPD3 RPS6KA4

2.35e-03162202f12c08d0d4406f9560ecfc3bc2ff38c3bc58f184
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.37e-031632027a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMPD3 RPS6KA4

2.37e-031632023087224d3f16f5d3aecc3e1e4366220231afe31f
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|metastatic_Brain / Location, Cell class and cell subclass

SMPD3 RPS6KA4

2.40e-0316420206db4cc064f0765c481ce880207823872c27bfa9
ToppCell356C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SMPD3 RPS6KA4

2.40e-03164202fed26f4ac36a2b0722bc7b9f91659c5e0cf4d53a
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1orf167 MAML2

2.40e-03164202d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCelldroplet-Fat-Scat-21m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.43e-031652023f0c2486ea357d10dad0b703cf75cc29bdd5b5cf
ToppCellNS-critical-d_07-13-Myeloid-pDC|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SMPD3 RPS6KA4

2.43e-0316520217d5c4a111d9b5400780bc5e7b93ce2f5d69ceb7
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-pDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SMPD3 RPS6KA4

2.46e-031662029fa90d9d484563d44738bb2c6eb0775dffc4d549
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPTN MESP2

2.49e-031672023dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPTN MESP2

2.49e-031672029480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.49e-03167202528493896aebe7d03d4b6ad2341b12927859e2e4
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPTN MESP2

2.49e-0316720295b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.49e-03167202a82e85caf79395baa48380786d9df32a86dfd1ce
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

SMPD3 RPS6KA4

2.52e-03168202dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCellNS-moderate-d_07-13-Myeloid-pDC|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SMPD3 RPS6KA4

2.52e-03168202d03e91f0e0518b33555c0ec98124fc5ed0f11be5
ToppCell10x5'-lymph-node_spleen-Myeloid_Dendritic-pDC|lymph-node_spleen / Manually curated celltypes from each tissue

SMPD3 RPS6KA4

2.52e-03168202cfed36fece51871a5abbcde71f6bd5e7212357ff
ToppCell390C-Myeloid-Dendritic-pDC|390C / Donor, Lineage, Cell class and subclass (all cells)

SMPD3 RPS6KA4

2.52e-031682025a2e7a52b7330dce30823695a7b9b26bc47a69ce
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.55e-03169202bb43abad2c049b7f4d307737347290e01b3339a3
ToppCellfacs-Heart-LV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.55e-03169202849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

COL5A3 MAML2

2.55e-031692026373562ab3b1765060212a6a53d6543e7e942e80
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.55e-031692025f18e3f40a5b1b167903f37516ec8181e889c7c5
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.55e-031692028bfa2d3bb541d02f55d7c95b8fd156c8403befca
ToppCellfacs-Heart-RV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.58e-03170202d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCellmetastatic_Lymph_Node-Myeloid_cells-pDCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

SMPD3 RPS6KA4

2.61e-031712021f8e66073088fc1969782e443bf00f8c1877ea91
ToppCellHealthy/Control-MAIT|World / Disease group and Cell class

COL5A3 PRDM8

2.61e-0317120261515114b17816a8f9ef6a57262eb9e977b6ede4
ToppCell390C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SMPD3 RPS6KA4

2.64e-031722023f894c74916d49a995b2d4651ca1c6733c14ce9c
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL5A3 KCNA6

2.64e-031722028d6a2a0d5f63b09a5a304a77e600a647f87e9de4
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMPD3 RPS6KA4

2.64e-031722023aed10e6db48254f4cae12fbe52d1a1fc6cf2dce
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

SMPD3 RPS6KA4

2.64e-03172202200b2e63313b110b8ca59ee5b72c02cc8ed907cd
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMPD3 RPS6KA4

2.64e-03172202b84610f1e5889a655652800c2b3270d264bfe1a9
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPD3 KCNA6

2.67e-0317320285fa5918e9c1f6bb4757e3350cfc71ee75c55640
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMPD3 KCNA6

2.67e-03173202e944ea3a0a368f856efacbda4600605cf751dd9c
ToppCellwk_15-18-Hematologic-Myeloid-pDC|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SMPD3 RPS6KA4

2.67e-03173202b571970e3ba88afc07041c5692ccfd85fc39e796
ToppCellHealthy/Control-MAIT|Healthy/Control / Disease group and Cell class

COL5A3 PRDM8

2.67e-0317320256247c1e07477a8922fe2e3950ae05e2217fd77c
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PRDM8 SMPD3

2.67e-031732024968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MTCH1 SMPD3

2.70e-03174202a1f745962a104c6f4b86b7e482da8755384c773a
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.70e-0317420268a6ed81e7e1f95b61f7ee20403980fa3a8db4d0
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL5A3 RPS6KA4

2.70e-031742021d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

NUP98 CREBBP

2.73e-03175202c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

MTCH1 SMPD3

2.73e-0317520278a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.76e-03176202c0a084f7a8645262d61971f094689e02bf15b113
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.76e-03176202f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCellB_cells-pDCs|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SMPD3 RPS6KA4

2.76e-03176202ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.76e-03176202cccf9201f6e2da7524b911a5961d3b227edab222
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL5A3 KCNA6

2.76e-03176202792f414f5092aba14260b8e16378e793a822498e
ToppCellCF-Lymphoid-pDC|CF / Disease state, Lineage and Cell class

SMPD3 RPS6KA4

2.76e-03176202dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.76e-03176202fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-pDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SMPD3 RPS6KA4

2.79e-03177202e36c2005be74ee8ff03c2052504cb496faf86009
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL5A3 KCNA6

2.79e-031772026b4fe717928814dafcd13090b1c90ea973938c6d
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL5A3 SMPD3

2.82e-03178202c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 SMPD3

2.82e-031782025fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMPD3 RPS6KA4

2.82e-03178202b7d1d8f76c1c2467b1a39a9b4150ed4a47144a15
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMPD3 RPS6KA4

2.85e-031792024808469096cd6bec2bdfcf4fc55aa324757600c3
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 KCNA6

2.85e-03179202c7c74e26bbf86c5326ee38bac7de111d5414f46b
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MESP2 SMPD3

2.85e-03179202adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-pDC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SMPD3 RPS6KA4

2.85e-03179202bbd4f8e988ef3f343aaedbc992b70f2bb6aff5f6
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMPD3 RPS6KA4

2.85e-031792024d55718c6afd8a038d93cc77b9b08171dab9976f
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRDM8 SMPD3

2.88e-03180202c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCellmild-Myeloid-pDC|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SMPD3 RPS6KA4

2.88e-0318020238614155fa537d0defda914c531c697be0ef06d8
ToppCellmoderate-Myeloid-pDC|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SMPD3 RPS6KA4

2.88e-03180202a0751ad5e42a21cb107d900abfa9ee967a0069fc
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SMPD3 RPS6KA4

2.88e-031802026a2366d76276452141db1bd93013a9503525f574
ToppCelltumor_Lung-Myeloid_cells-pDCs|tumor_Lung / Location, Cell class and cell subclass

SMPD3 RPS6KA4

2.92e-03181202c864ffeb9234b8c29754afc91c85a972889617f4
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.92e-03181202cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCellfacs-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 PRDM8

2.92e-03181202269b39ac65790061d54eab47a8eeb024403f0348
ToppCellwk_20-22-Hematologic-Myeloid-pDC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SMPD3 RPS6KA4

2.92e-0318120260607c5ff6d5b1cb416adc034491dca31c41e988
ToppCellSevere-Lymphoid-pDC-|Severe / Condition, Lineage, Cell class and cell subclass

SMPD3 RPS6KA4

2.92e-03181202277ce4c49121da0990a5933b19d2c6af9bbe253e
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRCP1 STRC

4.36e-072202DOID:0110471 (implicated_via_orthology)
Diseaseosteogenesis imperfecta (implicated_via_orthology)

SMPD3 SMAD4

4.36e-065202DOID:12347 (implicated_via_orthology)
Diseaseacute myeloid leukemia (implicated_via_orthology)

NUP98 CREBBP

2.87e-0512202DOID:9119 (implicated_via_orthology)
Diseasechronic obstructive pulmonary disease (biomarker_via_orthology)

SMPD3 SMAD4

1.63e-0428202DOID:3083 (biomarker_via_orthology)
Diseasepulse pressure measurement, alcohol drinking

PRDM8 C1orf167

1.03e-0370202EFO_0004329, EFO_0005763
Diseasedilated cardiomyopathy (implicated_via_orthology)

MTCH1 NCOA6

1.34e-0380202DOID:12930 (implicated_via_orthology)
Diseasediastolic blood pressure, alcohol drinking

PRDM8 C1orf167

2.87e-03118202EFO_0004329, EFO_0006336
Diseasesystolic blood pressure, alcohol drinking

PRDM8 C1orf167

3.37e-03128202EFO_0004329, EFO_0006335
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

NCOA6 SMAD4

4.42e-03147202DOID:9352 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GGGQSPQQQQQLAGG

AGAP3

6

Q96P47
GAVGQAQGQQEQGRG

C1orf167

761

Q5SNV9
QQGLGGQAQGQPNSA

CREBBP

96

Q92793
FGTNPGGLFGQQNQQ

NUP98

266

P52948
QAEGQGQGQGQGQGQ

MESP2

176

Q0VG99
GQGQGQGQGQGQGQG

MESP2

181

Q0VG99
QGQGQGQGQGQGQGQ

MESP2

186

Q0VG99
GQGQGQGQGQGQGQG

MESP2

191

Q0VG99
QGQGQGQGQGRRPGL

MESP2

196

Q0VG99
QVPFQGASGQGGQSQ

RPS6KA4

606

O75676
AGGGPRGQTPNHNQQ

SMPD3

271

Q9NY59
SSNNGGSGGINGEQQ

MAML2

141

Q8IZL2
ANQNVQHAGGQGAGP

NCOA6

551

Q14686
VQQQEQQPASGGGGQ

KCNA6

316

P17658
QQPASGGGGQNGQQA

KCNA6

321

P17658
FPNQGQQGFSGGQGP

BCL9L

841

Q86UU0
GQQGNHGSQGLPGPQ

COL5A3

641

P25940
LGGQQSQPSAGDGNQ

PRH1;

51

P02810
PQGGPNPSQAGQQQG

OTP

86

Q5XKR4
GGLGNDQNPGSQFSQ

MTCH1

291

Q9NZJ7
GGNDNQGQAPDGQSQ

USP9X

11

Q93008
GGGGKDQQQQQQEAP

PRDM8

206

Q9NQV8
ASGPQPGQQQNGFTG

SMAD4

241

Q13485
GQPEPDTNGQCQGGN

STRC

271

Q7RTU9
GQPEPDTNGQCQGGN

STRCP1

271

A6NGW2
QQTPGQEGYQNQGQG

RPTN

621

Q6XPR3