Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone modifying activity	MST1 KDM4D KDM5B BRCA2 KDM4E EZH1 KAT6B EZH2	3.11e-06	229	78	8	GO:0140993
GeneOntologyMolecularFunction	histone H3K27 trimethyltransferase activity	EZH1 EZH2	4.51e-05	3	78	2	GO:0140951
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM4D KDM5B KDM4E	1.75e-04	28	78	3	GO:0141052
GeneOntologyMolecularFunction	histone H3K27 methyltransferase activity	EZH1 EZH2	2.24e-04	6	78	2	GO:0046976
GeneOntologyMolecularFunction	histone H3K9me2/H3K9me3 demethylase activity	KDM4D KDM4E	2.24e-04	6	78	2	GO:0140684
GeneOntologyMolecularFunction	histone demethylase activity	KDM4D KDM5B KDM4E	2.38e-04	31	78	3	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM4D KDM5B KDM4E	2.62e-04	32	78	3	GO:0140457
GeneOntologyMolecularFunction	IgG receptor activity	FCGR2C FCGR2B	3.12e-04	7	78	2	GO:0019770
GeneOntologyMolecularFunction	chromatin binding	EBF2 PPARGC1A KDM4D MEIS3 KDM4E EZH1 KAT6B EZH2 ZNF354B MEIS1	5.88e-04	739	78	10	GO:0003682
GeneOntologyMolecularFunction	demethylase activity	KDM4D KDM5B KDM4E	6.77e-04	44	78	3	GO:0032451
GeneOntologyMolecularFunction	IgG binding	FCGR2C FCGR2B	8.10e-04	11	78	2	GO:0019864
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF18A MYO1A DNAH8 DNAH11	1.18e-03	118	78	4	GO:0003774
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM4D KDM4E	1.33e-03	14	78	2	GO:0032454
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR2C FCGR2B	1.33e-03	14	78	2	GO:0019763
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	BRCA2 KAT6B	1.53e-03	15	78	2	GO:0010484
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	EBF2 LHX4 ZNF341 MEIS3 RFX2 MEIS1 MEIS2 MEIS3P1	1.63e-03	566	78	8	GO:0001216
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM4D KDM5B KDM4E	2.10e-03	65	78	3	GO:0016706
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH8 DNAH11	2.21e-03	18	78	2	GO:0008569
GeneOntologyMolecularFunction	microtubule motor activity	KIF18A DNAH8 DNAH11	2.60e-03	70	78	3	GO:0003777
GeneOntologyBiologicalProcess	hepatocyte homeostasis	EZH1 EZH2	1.41e-05	2	78	2	GO:0036333
GeneOntologyBiologicalProcess	positive regulation of chromatin binding	EBF2 KDM4D KDM4E	1.84e-05	14	78	3	GO:0035563
GeneOntologyBiologicalProcess	regulation of mammary gland epithelial cell proliferation	MST1 KDM5B BRCA2	6.59e-05	21	78	3	GO:0033599
GeneOntologyBiologicalProcess	regulation of chromatin binding	EBF2 KDM4D KDM4E	9.94e-05	24	78	3	GO:0035561
GeneOntologyCellularComponent	chromatin	EBF2 PPARGC1A KDM4D DFFB KDM5B LHX4 UBR5 MEIS3 KDM4E EZH1 KAT6B EZH2 RFX2 MEIS1 MEIS2 NUFIP1 FAM111B	2.15e-05	1480	77	17	GO:0000785
GeneOntologyCellularComponent	pericentric heterochromatin	KDM4D KDM4E EZH2	2.21e-04	32	77	3	GO:0005721
GeneOntologyCellularComponent	heterochromatin	KDM4D KDM4E EZH1 EZH2	5.30e-04	101	77	4	GO:0000792
GeneOntologyCellularComponent	axoneme	MAK CFAP276 DNAH8 CFAP46 DNAH11	1.01e-03	207	77	5	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	MAK CFAP276 DNAH8 CFAP46 DNAH11	1.03e-03	208	77	5	GO:0097014
Domain	PKNOX/Meis_N	MEIS3 MEIS1 MEIS2	6.44e-07	5	76	3	IPR032453
Domain	Meis_PKNOX_N	MEIS3 MEIS1 MEIS2	6.44e-07	5	76	3	PF16493
Domain	JmjN	KDM4D KDM5B KDM4E	7.61e-06	10	76	3	SM00545
Domain	JMJN	KDM4D KDM5B KDM4E	7.61e-06	10	76	3	PS51183
Domain	JmjN	KDM4D KDM5B KDM4E	7.61e-06	10	76	3	PF02375
Domain	JmjN	KDM4D KDM5B KDM4E	7.61e-06	10	76	3	IPR003349
Domain	EZH2_WD-Binding	EZH1 EZH2	1.63e-05	2	76	2	PF11616
Domain	EZH1/EZH2	EZH1 EZH2	1.63e-05	2	76	2	IPR021654
Domain	CXC_dom	EZH1 EZH2	1.63e-05	2	76	2	IPR026489
Domain	CXC	EZH1 EZH2	1.63e-05	2	76	2	PS51633
Domain	Homeobox_KN	MEIS3 MEIS1 MEIS2	4.23e-05	17	76	3	PF05920
Domain	Homeobox_KN_domain	MEIS3 MEIS1 MEIS2	4.23e-05	17	76	3	IPR008422
Domain	JmjC	KDM4D KDM5B KDM4E	1.23e-04	24	76	3	PF02373
Domain	Tesmin/TSO1-like_CXC	EZH1 EZH2	2.43e-04	6	76	2	IPR033467
Domain	CXC	EZH1 EZH2	2.43e-04	6	76	2	SM01114
Domain	JMJC	KDM4D KDM5B KDM4E	2.95e-04	32	76	3	PS51184
Domain	JmjC_dom	KDM4D KDM5B KDM4E	2.95e-04	32	76	3	IPR003347
Domain	JmjC	KDM4D KDM5B KDM4E	3.24e-04	33	76	3	SM00558
Domain	DHC_N1	DNAH8 DNAH11	4.50e-04	8	76	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH8 DNAH11	4.50e-04	8	76	2	IPR013594
Domain	Dynein_heavy_chain_D4_dom	DNAH8 DNAH11	1.44e-03	14	76	2	IPR024317
Domain	Dynein_HC_stalk	DNAH8 DNAH11	1.44e-03	14	76	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH8 DNAH11	1.44e-03	14	76	2	IPR013602
Domain	DHC_N2	DNAH8 DNAH11	1.44e-03	14	76	2	PF08393
Domain	MT	DNAH8 DNAH11	1.44e-03	14	76	2	PF12777
Domain	AAA_8	DNAH8 DNAH11	1.44e-03	14	76	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH8 DNAH11	1.44e-03	14	76	2	IPR011704
Domain	AAA_5	DNAH8 DNAH11	1.44e-03	14	76	2	PF07728
Domain	DHC_fam	DNAH8 DNAH11	1.66e-03	15	76	2	IPR026983
Domain	Dynein_heavy_dom	DNAH8 DNAH11	1.66e-03	15	76	2	IPR004273
Domain	Dynein_heavy	DNAH8 DNAH11	1.66e-03	15	76	2	PF03028
Domain	Pept_cys_AS	BLMH DNAH8	5.77e-03	28	76	2	IPR000169
Pubmed	Identification of a conserved family of Meis1-related homeobox genes.	MEIS3 MEIS1 MEIS2 MEIS3P1	2.59e-11	4	80	4	9049632
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM4D KDM5B KDM4E EZH1 EZH2	9.99e-08	49	80	5	34368113
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM4D KDM5B KDM4E KAT6B EZH2	2.16e-07	57	80	5	18022353
Pubmed	Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.	MEIS3 MEIS1 MEIS2	4.07e-07	7	80	3	17178831
Pubmed	PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.	MEIS3 MEIS1 MEIS2	4.07e-07	7	80	3	12397630
Pubmed	Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis.	MEIS3 MEIS1 MEIS2	9.75e-07	9	80	3	12183364
Pubmed	Identification of a new family of Pbx-related homeobox genes.	MEIS3 MEIS1 MEIS2	1.39e-06	10	80	3	8950991
Pubmed	Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors.	MEIS3 MEIS1 MEIS2	1.91e-06	11	80	3	18787068
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	KDM4D KDM4E EZH2	1.91e-06	11	80	3	19144645
Pubmed	Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.	MEIS3 MEIS1 MEIS2	3.30e-06	13	80	3	16847320
Pubmed	Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.	MEIS3 MEIS1 MEIS2	3.30e-06	13	80	3	17049510
Pubmed	Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.	MEIS3 MEIS1 MEIS2	4.19e-06	14	80	3	15617687
Pubmed	Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice.	KDM4D KDM4E	5.23e-06	2	80	2	30472235
Pubmed	Repressive histone methylation regulates cardiac myocyte cell cycle exit.	KDM4D KDM4E	5.23e-06	2	80	2	29800554
Pubmed	The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma.	EZH1 EZH2	5.23e-06	2	80	2	38309675
Pubmed	Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.	EZH1 EZH2	5.23e-06	2	80	2	32428001
Pubmed	Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.	EZH1 EZH2	5.23e-06	2	80	2	9214638
Pubmed	Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation.	MEIS1 MEIS2	5.23e-06	2	80	2	18408019
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	5.23e-06	2	80	2	2531080
Pubmed	PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.	EZH1 EZH2	5.23e-06	2	80	2	28939884
Pubmed	Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.	MEIS1 MEIS2	5.23e-06	2	80	2	34035267
Pubmed	Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.	EZH1 EZH2	5.23e-06	2	80	2	8921387
Pubmed	Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.	EZH1 EZH2	5.23e-06	2	80	2	25578878
Pubmed	EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation.	EZH1 EZH2	5.23e-06	2	80	2	30522506
Pubmed	The role of EZH1 and EZH2 in development and cancer.	EZH1 EZH2	5.23e-06	2	80	2	36476271
Pubmed	Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.	EZH1 EZH2	5.23e-06	2	80	2	27526204
Pubmed	Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.	FCGR2C FCGR2B	5.23e-06	2	80	2	9516136
Pubmed	EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.	EZH1 EZH2	5.23e-06	2	80	2	21317239
Pubmed	Aberrant differential expression of EZH1 and EZH2 in Polycomb repressive complex 2 among B- and T/NK-cell neoplasms.	EZH1 EZH2	5.23e-06	2	80	2	27311868
Pubmed	The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration.	EZH1 EZH2	5.23e-06	2	80	2	25477280
Pubmed	Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling.	KDM4D KDM4E	5.23e-06	2	80	2	35027670
Pubmed	Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation.	KDM4D KDM4E	5.23e-06	2	80	2	25417163
Pubmed	Kdm4d mutant mice show impaired sperm motility and subfertility.	KDM4D KDM4E	5.23e-06	2	80	2	39034148
Pubmed	Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.	EZH1 EZH2	5.23e-06	2	80	2	9473645
Pubmed	Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas.	EZH1 EZH2	5.23e-06	2	80	2	31747604
Pubmed	The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6.	EZH1 EZH2	5.23e-06	2	80	2	10051331
Pubmed	EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer.	EZH1 EZH2	5.23e-06	2	80	2	30867289
Pubmed	MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease.	MEIS1 MEIS2	5.23e-06	2	80	2	29716922
Pubmed	EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy.	EZH1 EZH2	5.23e-06	2	80	2	27897169
Pubmed	Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice.	EZH1 EZH2	5.23e-06	2	80	2	30689973
Pubmed	Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling.	KDM4D KDM4E	5.23e-06	2	80	2	32094404
Pubmed	Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells.	MEIS3 MEIS1 MEIS2	5.23e-06	15	80	3	23756022
Pubmed	The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.	EZH1 EZH2 MEIS1	1.11e-05	19	80	3	32554463
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM4D KDM5B KDM4E	1.51e-05	21	80	3	27626377
Pubmed	Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.	MEIS1 MEIS2	1.57e-05	3	80	2	18216174
Pubmed	DNA-dependent formation of transcription factor pairs alters their binding specificity.	MEIS1 MEIS2	1.57e-05	3	80	2	26550823
Pubmed	The polycomb-group gene Ezh2 is required for early mouse development.	EZH1 EZH2	1.57e-05	3	80	2	11390661
Pubmed	Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.	EZH1 EZH2	1.57e-05	3	80	2	27630126
Pubmed	Conserved regulation of proximodistal limb axis development by Meis1/Hth.	MEIS1 MEIS2	1.57e-05	3	80	2	10586884
Pubmed	Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells.	MEIS3 MEIS1	1.57e-05	3	80	2	18223676
Pubmed	The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.	ERBB3 EIF2AK3	1.57e-05	3	80	2	32107308
Pubmed	Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.	EZH1 EZH2	1.57e-05	3	80	2	22042701
Pubmed	Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells.	EZH1 EZH2	1.57e-05	3	80	2	23673358
Pubmed	Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.	FCGR2C FCGR2B	1.57e-05	3	80	2	23261299
Pubmed	Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce β-defensin expression.	KDM4D KDM4E	1.57e-05	3	80	2	38905308
Pubmed	Signaling function of PRC2 is essential for TCR-driven T cell responses.	EZH1 EZH2	1.57e-05	3	80	2	29523590
Pubmed	Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.	EZH1 EZH2	1.57e-05	3	80	2	27823969
Pubmed	The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility.	KDM4D KDM4E	1.57e-05	3	80	2	21293030
Pubmed	Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.	EZH1 EZH2	1.57e-05	3	80	2	30396150
Pubmed	Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.	EZH1 EZH2	1.57e-05	3	80	2	26219303
Pubmed	The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice.	KDM4D KDM4E	1.57e-05	3	80	2	21555854
Pubmed	Functional Fcgamma receptor polymorphisms are associated with human allergy.	FCGR2C FCGR2B	1.57e-05	3	80	2	24586589
Pubmed	An autoinhibitory effect of the homothorax domain of Meis2.	MEIS3 MEIS2	1.57e-05	3	80	2	20553494
Pubmed	Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.	FCGR2C FCGR2B	1.57e-05	3	80	2	26133275
Pubmed	The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.	MEIS3 MEIS1 MEIS2	1.75e-05	22	80	3	22748019
Pubmed	Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.	MEIS3 MEIS1 MEIS2	1.75e-05	22	80	3	37823339
Pubmed	Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.	MEIS3 MEIS1 MEIS2	2.01e-05	23	80	3	18691704
Pubmed	Identification and characterization of cellular heterogeneity within the developing renal interstitium.	MEIS3 MEIS1 MEIS2	2.60e-05	25	80	3	32586976
Pubmed	Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death.	MEIS3 MEIS1 MEIS2	2.93e-05	26	80	3	26857994
Pubmed	Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs.	MEIS1 MEIS2	3.13e-05	4	80	2	37272420
Pubmed	DCIS in BRCA1 and BRCA2 mutation carriers: prevalence, phenotype, and expression of oncodrivers C-MET and HER3.	ERBB3 BRCA2	3.13e-05	4	80	2	26496879
Pubmed	Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.	EZH1 EZH2	3.13e-05	4	80	2	23932971
Pubmed	Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.	MEIS1 MEIS2	3.13e-05	4	80	2	27521061
Pubmed	Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.	MEIS3 MEIS1	3.13e-05	4	80	2	21059917
Pubmed	EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.	EZH1 EZH2	3.13e-05	4	80	2	19026780
Pubmed	Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.	EZH1 EZH2	3.13e-05	4	80	2	19026781
Pubmed	TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.	KDM4D KDM4E	3.13e-05	4	80	2	35145029
Pubmed	Regulation of embryonic haematopoietic multipotency by EZH1.	EZH1 EZH2	3.13e-05	4	80	2	29342143
Pubmed	Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.	EZH1 EZH2	3.13e-05	4	80	2	31189531
Pubmed	Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells.	KDM4D KDM4E	3.13e-05	4	80	2	32080306
Pubmed	Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling.	EZH1 EZH2	3.13e-05	4	80	2	37105173
Pubmed	Isolation and characterization of rat skeletal muscle and cytoplasmic actin genes.	KDM4D KDM4E	3.13e-05	4	80	2	6953429
Pubmed	The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells.	MEIS1 MEIS2	3.13e-05	4	80	2	16357834
Pubmed	Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.	MEIS3 MEIS1 MEIS2	3.29e-05	27	80	3	11566859
Pubmed	The DNA sequence and analysis of human chromosome 13.	ATP7B BRCA2 PCDH9 ATP4B NUFIP1	4.70e-05	170	80	5	15057823
Pubmed	ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.	MEIS3 MEIS1 MEIS2	5.03e-05	31	80	3	36445780
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KDM5B BRCA2 ZNF608 UBR5 USO1 ZNF318 VCPIP1	5.15e-05	418	80	7	34709266
Pubmed	A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.	EZH1 EZH2	5.20e-05	5	80	2	28320739
Pubmed	Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.	KDM4D KDM4E	5.20e-05	5	80	2	16738407
Pubmed	Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.	MEIS1 MEIS2	5.20e-05	5	80	2	10842069
Pubmed	PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome.	EZH1 EZH2	5.20e-05	5	80	2	32820269
Pubmed	Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.	EZH1 EZH2	5.20e-05	5	80	2	9584197
Pubmed	Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.	MST1 SAV1	5.20e-05	5	80	2	20080689
Pubmed	Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.	MEIS1 MEIS2	5.20e-05	5	80	2	25640223
Pubmed	HOX cofactors expression and regulation in the human ovary.	MEIS1 MEIS2	5.20e-05	5	80	2	18973687
Pubmed	Dental Epithelial Stem Cells Express the Developmental Regulator Meis1.	MEIS1 MEIS2	5.20e-05	5	80	2	30914971
Pubmed	SNPs of Fc-gamma receptor genes and chronic periodontitis.	FCGR2C FCGR2B	5.20e-05	5	80	2	20439936
Pubmed	Copy number, linkage disequilibrium and disease association in the FCGR locus.	FCGR2C FCGR2B	5.20e-05	5	80	2	20508037
Pubmed	Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.	KDM4D KDM4E	5.20e-05	5	80	2	21914792
Pubmed	Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.	FCGR2C FCGR2B	5.20e-05	5	80	2	19309690
GeneFamily	TALE class homeoboxes and pseudogenes	MEIS3 MEIS1 MEIS2 MEIS3P1	1.35e-06	26	58	4	526
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4D KDM5B KDM4E	6.04e-05	24	58	3	485
GeneFamily	Lysine methyltransferases\|Myb/SANT domain containing\|Polycomb repressive complex 2	EZH1 EZH2	1.50e-04	6	58	2	1347
GeneFamily	Non-clustered protocadherins	PCDH12 PCDH9	6.54e-04	12	58	2	21
GeneFamily	Dyneins, axonemal	DNAH8 DNAH11	1.33e-03	17	58	2	536
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	EZH1 EZH2	5.31e-03	34	58	2	487
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF608 ZNF341 FEZF1 ZNF318 ZNF510 ZNF362 ZNF354B	7.83e-03	718	58	7	28
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B-B_naive\|COVID-19_Mild / Disease, condition lineage and cell class	ZNF608 FCGR2B SAV1 ZCCHC7 EIF2AK3 PCDH9 FAM111B	7.45e-08	200	80	7	e6a43eff47195e1d39530ad49ad908fc06a8b038
ToppCell	Ciliated_cells-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	CFAP47 CFAP276 FYB2 CFAP46 TTLL7 DNAH11	5.14e-07	164	80	6	fd30c55d0d75ef8b9396435d836187168095152b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MAK MANBA SAV1 ZNF318 ZNF354B EIF2AK3	1.18e-06	189	80	6	b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF608 FCGR2B SAV1 ZNF318 ZCCHC7 PCDH9	1.21e-06	190	80	6	112706d64ee73b55dcf76f33ca064ab1fc6ce87f
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KIF18A MAK BRCA2 EZH2 MEIS2 CFAP46	1.21e-06	190	80	6	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 ZNF608 FYB2 MEIS2 CFAP46 DNAH11	1.33e-06	193	80	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZNF608 FCGR2B PLAAT2 DNAH8 PCDH9 MEIS1	1.41e-06	195	80	6	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	mild-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZNF608 SAV1 ZNF318 ZCCHC7 EIF2AK3 PCDH9	1.64e-06	200	80	6	222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCell	Control-Control-Lymphocyte-B-B_naive\|Control / Disease, condition lineage and cell class	ZNF608 FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	1.64e-06	200	80	6	15e4b9956b9a0c2e6927a802e86e1cb4bb18b89a
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B\|COVID-19_Mild / Disease, condition lineage and cell class	ZNF608 FCGR2B ZCCHC7 EIF2AK3 PCDH9 FAM111B	1.64e-06	200	80	6	11b51dfca161342d92126e0a83d10864348ba3ef
ToppCell	mild-B_naive\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZNF608 FCGR2B SAV1 ZCCHC7 EIF2AK3 PCDH9	1.64e-06	200	80	6	d0467cab6a42bf780aa49046bf3231ca161dc144
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP47 MAK FYB2 CFAP46 DNAH11	1.35e-05	169	80	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA2 EZH2 ATP4B TTLL7 FAM111B	1.35e-05	169	80	5	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GABRE PPARGC1A C12orf50 MCF2L MEIS2	1.35e-05	169	80	5	aec97583b23112060437b619cb429dc32f29285f
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 SAV1 ZCCHC7 EIF2AK3 PCDH9	1.47e-05	172	80	5	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GABRE ERBB3 ATP7B MCF2L MEIS1	1.78e-05	179	80	5	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GABRE MCF2L RFX2 EIF2AK3 MEIS2	2.09e-05	185	80	5	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D175\|Adult / Lineage, Cell type, age group and donor	ZNF608 PCDH12 MCF2L MEIS1 MEIS2	2.20e-05	187	80	5	f3548817f2fded5978137bb252cb628ac199e4f6
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF608 FCGR2B SAV1 ZCCHC7 PCDH9	2.20e-05	187	80	5	d01926be1c8846a25fb6706e26b56b808b69f8f0
ToppCell	normal-na-Lymphocytic_B-B_naive-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	ZNF608 SAV1 ZCCHC7 PCDH9 FAM111B	2.25e-05	188	80	5	ec72ba73b10c6f2ff39699b6b46b90a3e95a4c24
ToppCell	NS-critical-d_0-4-Lymphoid-NKT-proliferating\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KIF18A BRCA2 EZH2 PCDH9 FAM111B	2.31e-05	189	80	5	d6bd46abb072b13a6b72f1ca25d19f218cceb1ff
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.31e-05	189	80	5	dc440015949a768188c67661b6be63b1ead1a0f0
ToppCell	Control-Epithelial-Ciliated\|Control / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.31e-05	189	80	5	c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP47 CFAP276 PLAAT2 CFAP46 DNAH11	2.31e-05	189	80	5	a3cd4c2da4feb9bdcd8957f3e344d095da1367b8
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.31e-05	189	80	5	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP47 CFAP276 PLAAT2 CFAP46 DNAH11	2.31e-05	189	80	5	93b1026bb1ba759e5704561c9a5de14a30c08894
ToppCell	COVID_vent-Lymphocytic-B_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	ZNF608 FCGR2B SAV1 ZNF318 PCDH9	2.37e-05	190	80	5	40b5e9e8f8fd8d84cb5b43e67b49267082348e9f
ToppCell	cellseq2-Epithelial-Epithelial_Airway\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP47 CFAP276 PLAAT2 CFAP46 DNAH11	2.37e-05	190	80	5	17829f4de31b3d9e4d71ba4817d18842aa699773
ToppCell	COVID_vent-Lymphocytic-B_cell-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	ZNF608 FCGR2B SAV1 ZNF318 PCDH9	2.37e-05	190	80	5	a37a32dc1b931562a6660074e19d5598efc65284
ToppCell	Control-Lymphoid_B\|Control / Disease group, lineage and cell class	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.43e-05	191	80	5	0a760cd3a48c487ec899adb882fddea8914cfe0c
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.43e-05	191	80	5	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	10x5'-bone_marrow-Lymphocytic_B-Naive_B_cells\|bone_marrow / Manually curated celltypes from each tissue	FCGR2B ZNF318 ZCCHC7 EIF2AK3 PCDH9	2.49e-05	192	80	5	fa99243ff028498c6a67d207a93e02c48e69cd42
ToppCell	Healthy-B_naive\|Healthy / disease group, cell group and cell class	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.49e-05	192	80	5	5fddf679dcc9c0077d6bfe04c1e602863fb959eb
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.49e-05	192	80	5	e5ab932b4c2fed538161281ae07dfcdd82706fdd
ToppCell	IPF-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.49e-05	192	80	5	d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.49e-05	192	80	5	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.49e-05	192	80	5	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.55e-05	193	80	5	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_naive-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.55e-05	193	80	5	95ec708d963e9411e2dcf65650ae71a26e9d0e7f
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-9\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 SAV1 ZCCHC7 PCDH9 FAM111B	2.55e-05	193	80	5	d5d188a314da1b4c8390276d88173c09dd7ce4bf
ToppCell	normal-na-Lymphocytic_B-B_naive-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	FCGR2B ZNF318 ZCCHC7 PCDH9 FAM111B	2.55e-05	193	80	5	dd199163fc13f3d411fe741cf003237064349e22
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_naive\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.55e-05	193	80	5	d0d0835304647758e6ad4348402a4f76a76137a0
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFAP276 PLAAT2 FYB2 CFAP46 DNAH11	2.62e-05	194	80	5	756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell	PBMC-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	b6328575eedb19e0ad7f4d03041672f3dc146da0
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B-Naive_B_cells\|lymph-node_spleen / Manually curated celltypes from each tissue	FCGR2B ZNF318 ZCCHC7 EIF2AK3 PCDH9	2.62e-05	194	80	5	20967afbadb3cf80ba9f4d7ebda4e64389252e70
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FCGR2B PLAAT2 DNAH8 PCDH9 MEIS1	2.62e-05	194	80	5	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	PBMC-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	a8daf73c186a15adb9ea02793d4bd9cb35c66290
ToppCell	mild-Lymphocytic-B_cells_1\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FCGR2B SAV1 ZNF318 ZCCHC7 PCDH9	2.62e-05	194	80	5	fad1986cba9cd23ac68e639d7335fbcd6ae2a4e7
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_naive-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	83554ba6a789750a39af58537fd7044ce20d3f02
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_naive\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	56286db641cfb270e52f33989b8bf7b14d45010a
ToppCell	PBMC-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	39121c7d537ac103f6959271d814fd327be7114f
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZNF608 RIN2 MCF2L MEIS1 MEIS2	2.62e-05	194	80	5	68004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.62e-05	194	80	5	958e648138676d46698090b4046cb484083ae449
ToppCell	PBMC-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	60542304899b99caa38e4abf6b71ba986fa6c399
ToppCell	Control-Lymphoid_B-B_naive\|Control / Disease group, lineage and cell class	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	4f9600960a287cfc020c06b4af3528d4e5797916
ToppCell	COVID-19_Severe-B_naive\|World / disease group, cell group and cell class	ZNF608 FCGR2B ZNF318 ZCCHC7 PCDH9	2.62e-05	194	80	5	d363963a6caeedf4f9e9ad22dcf9b66b85c79a48
ToppCell	PBMC-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	b16b96e42ea9734731342d4c41ff1711bd149462
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 SAV1 ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	287439c51528d7bb13bd235875d85631dc91ed91
ToppCell	PBMC-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.62e-05	194	80	5	ad9a8cc57f54bdec4cd6990b2cace947b7a163c9
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.68e-05	195	80	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	FMNL3 GABRE PCDH12 MCF2L MEIS2	2.68e-05	195	80	5	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.68e-05	195	80	5	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF608 SAV1 ZCCHC7 PCDH9 FAM111B	2.68e-05	195	80	5	b74645072a063732d5be43036ce0e9568eff3d14
ToppCell	severe-Lymphocytic-B_cells_1\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	FCGR2B SAV1 ZNF318 ZCCHC7 PCDH9	2.68e-05	195	80	5	73e39005a597e13aea571ae6ae5824d1c7448b71
ToppCell	10x5'-bone_marrow-Lymphocytic_B\|bone_marrow / Manually curated celltypes from each tissue	FCGR2B ZNF318 ZCCHC7 EIF2AK3 PCDH9	2.68e-05	195	80	5	bcbf0305ca9337a6f3021178dbb47a7fbf1030a4
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.68e-05	195	80	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF608 SAV1 ZCCHC7 PCDH9 FAM111B	2.68e-05	195	80	5	4b882a71f0e02fef5580e9d9bc42245cf9df2e57
ToppCell	mild_COVID-19_(asymptomatic)-B_naive\|World / disease group, cell group and cell class (v2)	ZNF608 SAV1 ZCCHC7 PCDH9 FAM111B	2.68e-05	195	80	5	e763d9a431052c03cc6d514f2736506c6667e2be
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.75e-05	196	80	5	d7e6c89cb49933b4a86d26d15f6772f2481d37ef
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.75e-05	196	80	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.75e-05	196	80	5	fcbfd8c4771d99a45fc53e482ef98edabe8ef591
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.75e-05	196	80	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	2.75e-05	196	80	5	f45cb8f714ae7ac800768df65f299b98a2d42962
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	FMNL3 GABRE PCDH12 MCF2L MEIS2	2.75e-05	196	80	5	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	CFAP47 CFAP276 FYB2 CFAP46 DNAH11	2.75e-05	196	80	5	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	mild-Lymphocytic-B_cells_1\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ZNF608 FCGR2B SAV1 ZCCHC7 PCDH9	2.75e-05	196	80	5	1988088dd7e1ba947339fd1331beed482955e607
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 FCGR2B SAV1 ZCCHC7 PCDH9	2.82e-05	197	80	5	f7a8440d2b8b17d9726c6fe3dd383effbfebab13
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CFAP276 RFX2 CFAP46 DNAH11	2.82e-05	197	80	5	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF608 FCGR2B SAV1 ZCCHC7 PCDH9	2.82e-05	197	80	5	7cae4f3eabfebce101de7bb7defb17d6c5360b58
ToppCell	COVID-19_Severe-B_naive\|COVID-19_Severe / disease group, cell group and cell class	ZNF608 FCGR2B ZNF318 ZCCHC7 PCDH9	2.82e-05	197	80	5	b8f18b39435e2229ba3bc07a25eb875d1ec11f6f
ToppCell	distal-Hematologic-Proliferating_Macrophage-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KIF18A LHX4 BRCA2 EZH2 FAM111B	2.89e-05	198	80	5	8afeb1f9bc9d8551482c8fefe4c5f88d9cd13ee2
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-B-B_intermediate\|Leuk-UTI / Disease, condition lineage and cell class	ZNF608 FCGR2B ZCCHC7 PCDH9 FAM111B	2.96e-05	199	80	5	e3edf3bcb381dbcf0092bdc2ee93ba852d32af3f
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ZNF608 UBR5 PCDH12 MCF2L MEIS2	3.03e-05	200	80	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-B-B_naive\|COVID-19_Severe / Disease, condition lineage and cell class	ZNF608 FCGR2B ZNF318 ZCCHC7 PCDH9	3.03e-05	200	80	5	5ba9c541fa356d34f392a63274dcd7bfb844cbb6
ToppCell	severe-B_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FCGR2B SAV1 ZNF318 ZCCHC7 PCDH9	3.03e-05	200	80	5	0e86f52b6e146d9bbc728d8fb176fc2b53696558
ToppCell	Control-Control-Lymphocyte-B\|Control / Disease, condition lineage and cell class	FCGR2B SAV1 ZCCHC7 PCDH9 FAM111B	3.03e-05	200	80	5	d95551392de7316b72eacf1e4a1cb23452991fa0
ToppCell	severe-B_naive\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FCGR2B SAV1 ZNF318 ZCCHC7 PCDH9	3.03e-05	200	80	5	306df1f498ac2188eaf9f2a8d002bb73bdb9642d
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 EIF2AK3 PCDH9 FAM111B	9.98e-05	134	80	4	8707210b2a5d33baa1d204e9e2ed8921181cb309
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 ZNF318 ZCCHC7 PCDH9	1.32e-04	144	80	4	b2a9f3b5dd46d27689467f4a5fd717cd5827821f
ToppCell	Ciliated_cells-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	MAK CFAP276 FYB2 CFAP46	1.50e-04	149	80	4	6399c5a2f06d79f020dece252526f1c0c110d569
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	CFAP47 RFX2 CFAP46 DNAH11	1.58e-04	151	80	4	8216462e723fec2797387929dde095370947e10a
ToppCell	LPS-IL1RA-Epithelial_airway-Ciliated_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CFAP276 FYB2 CFAP46 DNAH11	1.58e-04	151	80	4	81cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCell	LPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CFAP276 FYB2 CFAP46 DNAH11	1.58e-04	151	80	4	9cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCell	Ciliated_cells-A-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	CFAP276 CFAP46 SEMA3E DNAH11	1.71e-04	154	80	4	3b938e23324f7edb56797b4a76fb96ff588142cf
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAK CFAP276 CFAP46 DNAH11	1.71e-04	154	80	4	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAK CFAP276 CFAP46 DNAH11	1.71e-04	154	80	4	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF18A C12orf50 BRCA2 FAM111B	1.79e-04	156	80	4	b3f10cd044f24807576e7d56e51df7064dbf6c50
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 BRCA2 CFAP46 DNAH11	1.84e-04	157	80	4	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF608 FCGR2B ZCCHC7 PCDH9	1.97e-04	160	80	4	8396afbc7d919ba190863d50aa0ef8b9942a9866
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FCGR2B SPECC1 PCDH9 FAM111B	2.02e-04	161	80	4	1670108afc0af90861eb80a84e59995571c0da1b
Disease	restless legs syndrome (implicated_via_orthology)	MEIS3 MEIS1 MEIS2 MEIS3P1	3.14e-09	8	78	4	DOID:0050425 (implicated_via_orthology)
Disease	leukemia (implicated_via_orthology)	MEIS3 MEIS1 MEIS2 MEIS3P1	1.70e-07	19	78	4	DOID:1240 (implicated_via_orthology)
Disease	urate measurement, bone density	FSIP2 PPARGC1A USO1 FEZF1 RC3H1 KAT6B DNAH8 C7orf33 MEIS1 DNAH11	5.36e-06	619	78	10	EFO_0003923, EFO_0004531
Disease	systemic lupus erythematosus (implicated_via_orthology)	FCGR2C FCGR2B RC3H1	2.03e-04	43	78	3	DOID:9074 (implicated_via_orthology)
Disease	plexin-B2 measurement	FCGR2C FCGR2B	2.45e-04	9	78	2	EFO_0021867
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2B	2.45e-04	9	78	2	DOID:12365 (implicated_via_orthology)
Disease	HYPOGONADOTROPIC HYPOGONADISM 7 WITH OR WITHOUT ANOSMIA	FEZF1 SEMA3E	3.74e-04	11	78	2	146110
Disease	Hypogonadotropic hypogonadism 7 with or without anosmia	FEZF1 SEMA3E	3.74e-04	11	78	2	cv:C0342384
Disease	Mammary Carcinoma, Human	MST1 ARHGDIA ERBB3 ATP7B BRCA2 EZH2 MEIS1	4.82e-04	525	78	7	C4704874
Disease	Mammary Neoplasms, Human	MST1 ARHGDIA ERBB3 ATP7B BRCA2 EZH2 MEIS1	4.82e-04	525	78	7	C1257931
Disease	Mammary Neoplasms	MST1 ARHGDIA ERBB3 ATP7B BRCA2 EZH2 MEIS1	4.93e-04	527	78	7	C1458155
Disease	Malignant neoplasm of breast	MST1 ARHGDIA ERBB3 ATP7B BRCA2 ZNF318 KAT6B EZH2 RFX2 MEIS1	5.22e-04	1074	78	10	C0006142
Disease	Breast Carcinoma	MST1 ARHGDIA ERBB3 ATP7B BRCA2 EZH2 MEIS1	5.57e-04	538	78	7	C0678222
Disease	Chromosome Breaks	DFFB EZH2	6.15e-04	14	78	2	C0333704
Disease	Chromosome Breakage	DFFB EZH2	6.15e-04	14	78	2	C0376628
Disease	breast cancer (is_implicated_in)	KDM5B BRCA2 UBR5 KAT6B	6.83e-04	150	78	4	DOID:1612 (is_implicated_in)
Disease	Benign neoplasm of stomach	ERBB3 UBR5	9.14e-04	17	78	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB3 UBR5	9.14e-04	17	78	2	C0496905
Disease	respiratory symptom change measurement, response to placebo	EBF2 PPARGC1A	9.14e-04	17	78	2	EFO_0008344, EFO_0010068
Disease	Carcinoma in situ of stomach	ERBB3 UBR5	9.14e-04	17	78	2	C0154060
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2B	9.14e-04	17	78	2	EFO_0021969
Disease	Idiopathic hypogonadotropic hypogonadism	FEZF1 SEMA3E	1.03e-03	18	78	2	C0342384
Disease	gut microbiome measurement, bone density	PPARGC1A FCGR2C FCGR2B	1.17e-03	78	78	3	EFO_0003923, EFO_0007874
Disease	nose morphology measurement, mouth morphology measurement	MEIS3 MEIS3P1	1.40e-03	21	78	2	EFO_0007843, EFO_0007955
Disease	Stomach Carcinoma	ERBB3 UBR5	1.40e-03	21	78	2	C0699791
Disease	Dyslipidemias	ATP7B DNAH11	1.83e-03	24	78	2	C0242339
Disease	Dyslipoproteinemias	ATP7B DNAH11	1.83e-03	24	78	2	C0598784
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2B	1.99e-03	25	78	2	EFO_0021970
Disease	chronotype measurement	FEZF1 ZNF318 ZCCHC7 EZH2 DUS3L EIF2AK3 MEIS1 MEIS2	2.29e-03	882	78	8	EFO_0008328

Protein segments in the cluster

Peptide	Gene	Start	Entry
VNNKHDDRYTPLPSN	PLAAT2	76	Q9NWW9
NKLTFQLEPNPHTKY	ERBB3	266	P21860
FRHDYVLNVQAKPKP	CA5B	296	Q9Y2D0
VVQYFKHKNLPPTNS	CPNE2	531	Q96FN4
DHPPKLYHSALNRQK	CFAP97	416	Q9P2B7
LDNPHYNKNIRKKDP	EIF2AK3	501	Q9NZJ5
QRYFPNPNKHISQTE	ATP7B	951	P35670
IPTHTQPSYRFKANN	FCGR2B	91	P31994
AAPFIKSHVPQKYRQ	CFAP46	201	Q8IYW2
AHFEKQPPSNLRKSN	EBF2	51	Q9HAK2
PAHIPYQELNSQEKK	SPECC1	1006	Q5M775
KLANPHYKPELQAQT	DNAH11	3586	Q96DT5
THKLNCDPSRIYKPQ	DFFB	311	O76075
KHRQPLQQKPYNNHS	DCP2	291	Q8IU60
QNKGRPHVKPTNYDK	DUS3L	106	Q96G46
KAQPHYSNPLVAAKL	ATP4B	236	P51164
SYATGRHKKPNPHQN	C7orf33	61	Q8WU49
SKKLPYKNPTHLAQQ	CFAP276	26	Q5T5A4
KGADQQQPPQHSKYK	RC3H1	401	Q5TC82
ESTYRQQPKRPQKHI	PCDH12	756	Q9NPG4
PAKVQSKNKYLHSPE	KAT6B	1036	Q8WYB5
THPYPSEEQKKQLAQ	MEIS1	296	O00470
HEVPLQERKNYKSSP	RELCH	231	Q9P260
PQINYKLSVEHKQRP	FLII	741	Q13045
NDPHFIIYLPKSQKN	ITIH2	701	P19823
KSPNYIRCIKPNEHQ	MYO1A	581	Q9UBC5
ADSKRKNQHIPYRNS	KIF18A	296	Q8NI77
HPYPSEEQKKQLAQD	MEIS2	301	O14770
PRNYAKLPAKHTSHN	MFI	101	Q8NCR3
PNKHSLSSLPIYNTK	FSIP2	2961	Q5CZC0
SKETTRYNHPKPNLL	GPATCH4	91	Q5T3I0
LHPFHATPNTYKRKN	EZH2	296	Q15910
IPTHTQPSYRFKANN	FCGR2C	91	P31995
NSPDLAKHYKSASPQ	PCDH9	931	Q9HC56
DYQLHPRKPNRSQSS	CSNKA2IP	691	A0A1B0GTH6
KLYHSQKDDPPLARN	DNAH8	496	Q96JB1
NSKKYQTPPHQNFED	KDM4D	106	Q6B0I6
LANSKKYQTPPHQNF	KDM4E	101	B2RXH2
SHPYPSEEQKKQLAQ	MEIS3	286	Q99687
TLKNAYKNSPKPARH	LHX4	171	Q969G2
YNQTKAHASPKLRHP	GABRE	366	P78334
KEYKPHDIPQRQSVQ	KDM5B	206	Q9UGL1
PHKANQDNPFRASPK	PPARGC1A	301	Q9UBK2
KTQTNQRGPPLYTKH	CEFIP	401	Q711Q0
EHKNNNYEPNLFKTP	BRCA2	51	P51587
DEHSVNYKPPAQKSI	ARHGDIA	21	P52565
ERFQVKNPPHTYIQK	FMNL3	71	Q8IVF7
KNPPHTYIQKLQSFL	FMNL3	76	Q8IVF7
PKQAPYSRNKALANS	GALNT12	366	Q8IXK2
VNDPRPQHKYNKLYT	BLMH	271	Q13867
YRQKALSCHPDKNPD	DNAJC17	31	Q9NVM6
KTKYAFSPRNSLPQH	IL10RB	251	Q08334
KRPTASQALKHPYFQ	MAK	271	P20794
AAQQSKAHTRYQVPP	MANBA	151	O00462
NSYSSPQRPNEAKKE	MCF2L	16	O15068
HKFPNDHKYTPTLRN	MST1	136	P26927
PPQDLSHYIKDKTRQ	FAM111B	326	Q6SJ93
KIKHARVYNNSPEPI	CFAP47	266	Q6ZTR5
HLYQHQDPDPKKASR	OR6A2	311	O95222
HPYPSEEQKKQLAQD	MEIS3P1	186	A6NDR6
KHELYSRASQKPQPN	USO1	586	O60763
HQKPRYRPAQKTDSL	RFX2	296	P48378
HPQPKTYLAERNKLV	FEZF1	191	A0PJY2
NGKPLSSNHKQRTPY	FYB2	51	Q5VWT5
APRPQNKMSYHRNNK	C12orf50	311	Q8NA57
AEHKKLPQPYNSLQE	XIRP2	2706	A4UGR9
TNKKAQYRHPCAPSV	SAV1	256	Q9H4B6
TYPQKIKAELHSRPQ	RIN2	851	Q8WYP3
SLLPQHSPKKDNAVY	ZNF341	526	Q9BYN7
RFPRHQKSFNPAVKN	NUFIP1	126	Q9UHK0
KTQQYHKEREQPPRF	PSPC1	251	Q8WXF1
PFHATPNVYKRKNKE	EZH1	311	Q92800
PQHPELQKYEKTNTF	USP29	686	Q9HBJ7
ILHQTAKKNPDDYTP	VCPIP1	651	Q96JH7
AKLHSAIYQNVPAKP	USP20	486	Q9Y2K6
QHANQYRSKSPAPVE	ZNF608	1421	Q9ULD9
SKLPYIKAANENPHH	ZCCHC7	411	Q8N3Z6
HQRQHNKDKPYKCPN	ZNF362	331	Q5T0B9
NYNENLPKHPKFQTL	ZNF510	236	Q9Y2H8
YANPQEKKLRSKPEH	SEMA3E	751	O15041
AQENPHKYNPGRKAS	ZNF354B	321	Q96LW1
HNKKHTQTLDPYNRP	ZNF318	1086	Q5VUA4
YNLKPSNHYKLIQQP	TTLL7	581	Q6ZT98
SEKLNKYNLNSHPPL	UBR5	26	O95071