Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	radial spoke head	RSPH1 RSPH6A	1.19e-04	5	73	2	GO:0001535
Domain	HECT	SMURF1 HERC2 SMURF2	1.63e-04	27	74	3	PF00632
Domain	HECTc	SMURF1 HERC2 SMURF2	1.63e-04	27	74	3	SM00119
Domain	HECT_dom	SMURF1 HERC2 SMURF2	1.63e-04	27	74	3	IPR000569
Domain	HECT	SMURF1 HERC2 SMURF2	1.63e-04	27	74	3	PS50237
Domain	RRM	RBMXL2 RBMXL3 EIF4B RBM6 SRSF9 HNRNPH3	2.20e-04	217	74	6	SM00360
Domain	Adcy_conserved_dom	ADCY2 ADCY6	2.30e-04	6	74	2	IPR009398
Domain	DUF1053	ADCY2 ADCY6	2.30e-04	6	74	2	PF06327
Domain	RRM_dom	RBMXL2 RBMXL3 EIF4B RBM6 SRSF9 HNRNPH3	2.81e-04	227	74	6	IPR000504
Domain	RRM	RBMXL2 RBMXL3 EIF4B RBM6 SRSF9 HNRNPH3	3.01e-04	230	74	6	PS50102
Domain	-	RBMXL2 RBMXL3 EIF4B RBM6 SRSF9 HNRNPH3	4.12e-04	244	74	6	3.30.70.330
Domain	AC_N	ADCY2 ADCY6	4.27e-04	8	74	2	IPR032628
Domain	Adcy	ADCY2 ADCY6	4.27e-04	8	74	2	IPR030672
Domain	AC_N	ADCY2 ADCY6	4.27e-04	8	74	2	PF16214
Domain	Nucleotide-bd_a/b_plait	RBMXL2 RBMXL3 EIF4B RBM6 SRSF9 HNRNPH3	5.54e-04	258	74	6	IPR012677
Domain	MORN	RSPH1 ALS2CL	1.37e-03	14	74	2	SM00698
Domain	RRM_1	RBMXL2 RBMXL3 EIF4B SRSF9 HNRNPH3	1.41e-03	208	74	5	PF00076
Domain	MORN	RSPH1 ALS2CL	1.57e-03	15	74	2	IPR003409
Domain	MORN	RSPH1 ALS2CL	1.57e-03	15	74	2	PF02493
Domain	A/G_cyclase_CS	ADCY2 ADCY6	2.03e-03	17	74	2	IPR018297
Domain	Nucleotide_cyclase	ADCY2 ADCY6	2.27e-03	18	74	2	IPR029787
Domain	-	ADCY2 ADCY6	2.27e-03	18	74	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY2 ADCY6	2.54e-03	19	74	2	PS00452
Domain	Guanylate_cyc	ADCY2 ADCY6	2.54e-03	19	74	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY2 ADCY6	2.54e-03	19	74	2	PS50125
Domain	A/G_cyclase	ADCY2 ADCY6	2.54e-03	19	74	2	IPR001054
Domain	CYCc	ADCY2 ADCY6	2.54e-03	19	74	2	SM00044
Domain	DEAD/DEAH_box_helicase_dom	BLM DDX3Y DDX3X	3.04e-03	73	74	3	IPR011545
Domain	DEAD	BLM DDX3Y DDX3X	3.04e-03	73	74	3	PF00270
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	GAS1 SMURF1 PSMC2 ADCY2 SMURF2 ADCY6	8.44e-06	137	50	6	MM15182
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	GAS1 SMURF1 PSMC2 ADCY2 SMURF2 ADCY6	1.42e-05	150	50	6	M27440
Pathway	REACTOME_HEDGEHOG_ON_STATE	GAS1 SMURF1 PSMC2 SMURF2	1.91e-04	81	50	4	MM15225
Pathway	REACTOME_HEDGEHOG_ON_STATE	GAS1 SMURF1 PSMC2 SMURF2	2.40e-04	86	50	4	M27497
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	GAS1 SMURF1 SMURF2	4.69e-04	43	50	3	M39706
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	ADCY2 ADCY6 GABBR1	4.69e-04	43	50	3	M954
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	ADCY2 ADCY6 GABBR1	5.02e-04	44	50	3	MM15709
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY2 ADCY6	5.45e-04	10	50	2	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY2 ADCY6	5.45e-04	10	50	2	MM14668
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	CACNA1F MYLK ADCY2 ADCY6	7.25e-04	115	50	4	M9387
Pathway	REACTOME_REGULATION_OF_RUNX3_EXPRESSION_AND_ACTIVITY	SMURF1 PSMC2 SMURF2	8.21e-04	52	50	3	MM15536
Pathway	REACTOME_REGULATION_OF_RUNX3_EXPRESSION_AND_ACTIVITY	SMURF1 PSMC2 SMURF2	9.67e-04	55	50	3	M27809
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY2 ADCY6	1.09e-03	14	50	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY2 ADCY6	1.09e-03	14	50	2	M750
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	ADCY2 ADCY6 GABBR1	1.25e-03	60	50	3	MM15708
Pathway	REACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS	SMURF1 PSMC2 SMURF2	1.25e-03	60	50	3	MM15150
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	ADCY2 ADCY6 GABBR1	1.25e-03	60	50	3	M976
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY2 ADCY6	1.26e-03	15	50	2	M47794
Pathway	PID_LPA4_PATHWAY	ADCY2 ADCY6	1.26e-03	15	50	2	M56
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6	1.26e-03	15	50	2	M47504
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6	1.43e-03	16	50	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6	1.43e-03	16	50	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY2 ADCY6	1.43e-03	16	50	2	MM14492
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY2 ADCY6	1.43e-03	16	50	2	M39849
Pathway	BIOCARTA_EFP_PATHWAY	SMURF1 SMURF2	1.43e-03	16	50	2	M22011
Pathway	REACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS	SMURF1 PSMC2 SMURF2	1.50e-03	64	50	3	M27396
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY2 ADCY6	1.62e-03	17	50	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY2 ADCY6	1.62e-03	17	50	2	M47544
Pathway	REACTOME_G2_M_CHECKPOINTS	BLM NSD2 PSMC2 HERC2	1.63e-03	143	50	4	MM15383
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	NSD2 EIF4B ZRANB2 PSMC2 SRSF9 PRRC2A HNRNPH3 DDX3X KHSRP	4.17e-07	441	74	9	31239290
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	BLM GALC ZC3H4 NSD2 ZRANB2 SMURF1 MKX RBM6 DDX3Y SRSF9 HNRNPH3 DDX3X KHSRP	4.29e-07	1082	74	13	38697112
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC71L PRR12 CELSR1 TNRC18 ABCA2 PLOD3 NSD2 KHNYN HERC2 SMURF2 C8orf58 PLEKHH3 MAPK8IP3	5.44e-07	1105	74	13	35748872
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	PLOD3 STX18 ZC3H4 EIF4B GAS1 PSMC2 HERC2 SRSF9 PRRC2A HNRNPH3 DDX3X KHSRP	5.44e-07	922	74	12	27609421
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BLM RBMXL2 ZC3H4 EIF4B ZRANB2 RBM6 SRSF9 PRRC2A ADCY6 MEF2D MAPK8IP3	7.22e-07	774	74	11	15302935
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	BLM ZC3H4 NSD2 EIF4B RBM6 DDX3Y SRSF9 PRRC2A MEF2D HNRNPH3 DDX3X KHSRP	7.79e-07	954	74	12	36373674
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	EIF4B RBM6 SRSF9 PRRC2A HNRNPH3 DDX3X KHSRP	1.34e-06	258	74	7	37794589
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ABCA2 ZC3H4 NSD2 ADCY2 MAPK8IP3	2.97e-06	104	74	5	10470851
Pubmed	Proteomic analysis reveals that MAEL, a component of nuage, interacts with stress granule proteins in cancer cells.	EIF4B DDX3X KHSRP	4.13e-06	15	74	3	24189637
Pubmed	Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.	RBMXL2 RBMXL3	4.47e-06	2	74	2	18562473
Pubmed	Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.	DDX3Y DDX3X	4.47e-06	2	74	2	34437837
Pubmed	Characterization of D1Pas1, a mouse autosomal homologue of the human AZFa region DBY, as a nuclear protein in spermatogenic cells.	DDX3Y DDX3X	4.47e-06	2	74	2	11591417
Pubmed	Structural characterization and expression studies of Dby and its homologs in the mouse.	DDX3Y DDX3X	4.47e-06	2	74	2	16728723
Pubmed	An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.	RBMXL2 RBMXL3	4.47e-06	2	74	2	30674417
Pubmed	The functions and regulation of Smurfs in cancers.	SMURF1 SMURF2	4.47e-06	2	74	2	31899247
Pubmed	Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.	SMURF1 SMURF2	4.47e-06	2	74	2	18927080
Pubmed	An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility.	DDX3Y DDX3X	4.47e-06	2	74	2	30613052
Pubmed	Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation.	DDX3Y DDX3X	4.47e-06	2	74	2	35588748
Pubmed	Gene structure of the human DDX3 and chromosome mapping of its related sequences.	DDX3Y DDX3X	4.47e-06	2	74	2	11710523
Pubmed	SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.	SMURF1 SMURF2	4.47e-06	2	74	2	33090007
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZC3H4 EIF4B ZRANB2 RBM6 SRSF9 PRRC2A HNRNPH3 PURG DDX3X KHSRP	8.05e-06	807	74	10	22681889
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	HDAC11 STX18 EIF4B DUSP9 RBM6 BCL2L2 ZCCHC2 ADCY6 HNRNPH3 GABBR1 DDX3X	1.02e-05	1021	74	11	26760575
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	FGA ABLIM2 PRRC2A GABBR1 PURG MAPK8IP3	1.02e-05	231	74	6	16452087
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	BLM ZC3H4 RBM6 TXLNG SRSF9 PRRC2A MEF2D KHSRP	1.18e-05	503	74	8	16964243
Pubmed	Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.	SMURF1 SMURF2	1.34e-05	3	74	2	37537194
Pubmed	The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.	SMURF1 SMURF2	1.34e-05	3	74	2	23475958
Pubmed	Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.	SMURF1 SMURF2	1.34e-05	3	74	2	25051198
Pubmed	USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.	SMURF1 SMURF2	1.34e-05	3	74	2	30244169
Pubmed	Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.	SMURF1 SMURF2	1.34e-05	3	74	2	15173588
Pubmed	HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN.	BLM HERC2	1.34e-05	3	74	2	33432007
Pubmed	Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.	SMURF1 SMURF2	1.34e-05	3	74	2	24925320
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ABCA2 STX18 RSPH1 IQSEC2 HERC2 TXLNG PRRC2A SMURF2 MSTO1 DDX3X CREBZF MAPK8IP3	1.62e-05	1285	74	12	35914814
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PRR12 TNRC18 ZBTB39 EIF4B ZRANB2 BCL2L2 TXLNG PRRC2A MEF2D DDX3X KHSRP	2.09e-05	1103	74	11	34189442
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	SMURF1 HERC2 SMURF2	2.32e-05	26	74	3	26949039
Pubmed	Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.	SMURF1 SMURF2	2.67e-05	4	74	2	30566427
Pubmed	Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.	SMURF1 SMURF2	2.67e-05	4	74	2	34370213
Pubmed	Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.	SMURF1 SMURF2	2.67e-05	4	74	2	16373342
Pubmed	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation.	SMURF1 SMURF2	2.67e-05	4	74	2	27086113
Pubmed	The WW1 Domain Enhances Autoinhibition in Smurf Ubiquitin Ligases.	SMURF1 SMURF2	2.67e-05	4	74	2	31628949
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	PLOD3 RBM6 PRRC2A HNRNPH3 DDX3X KHSRP	2.68e-05	274	74	6	34244482
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BLM ZC3H4 PAXX ZRANB2 DDX3X KHSRP	3.21e-05	283	74	6	30585729
Pubmed	USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.	EIF4B DDX3Y SRSF9 DDX3X	3.36e-05	85	74	4	29228324
Pubmed	Mammalian adenylyl cyclase family members are randomly located on different chromosomes.	ADCY2 ADCY6	4.45e-05	5	74	2	7959689
Pubmed	An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.	SMURF1 SMURF2	4.45e-05	5	74	2	28839186
Pubmed	Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.	SMURF1 SMURF2	4.45e-05	5	74	2	14722617
Pubmed	Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.	SMURF1 SMURF2	4.45e-05	5	74	2	21402695
Pubmed	NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.	SMURF1 SMURF2	4.45e-05	5	74	2	28798345
Pubmed	RSPH6A is required for sperm flagellum formation and male fertility in mice.	RSPH1 RSPH6A	4.45e-05	5	74	2	30185526
Pubmed	Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.	SMURF1 SMURF2	4.45e-05	5	74	2	20937913
Pubmed	Inhibition of HECT E3 ligases as potential therapy for COVID-19.	SMURF1 SMURF2	4.45e-05	5	74	2	33762578
Pubmed	Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals.	DDX3Y DDX3X	4.45e-05	5	74	2	8144024
Pubmed	Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.	ADCY2 ADCY6	4.45e-05	5	74	2	21228062
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	BLM ZC3H4 EIF4B ZRANB2 RBM6 PSMC2 SRSF9 HNRNPH3 DDX3X KHSRP	4.57e-05	989	74	10	36424410
Pubmed	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.	SMURF1 SMURF2	6.66e-05	6	74	2	21897371
Pubmed	ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.	SMURF1 SMURF2	6.66e-05	6	74	2	28049720
Pubmed	Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.	SMURF1 SMURF2	6.66e-05	6	74	2	19318350
Pubmed	Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.	SMURF1 SMURF2	6.66e-05	6	74	2	22921829
Pubmed	Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM.	RSPH1 RSPH6A	6.66e-05	6	74	2	34871179
Pubmed	Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.	ADCY2 ADCY6	6.66e-05	6	74	2	7766992
Pubmed	Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.	SMURF1 SMURF2	6.66e-05	6	74	2	32361710
Pubmed	Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.	ADCY2 ADCY6	6.66e-05	6	74	2	11549699
Pubmed	Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.	SMURF1 SMURF2	6.66e-05	6	74	2	23781096
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BLM PRR12 CELSR1 PLOD3 STX18 TBC1D30 NSD2 EIF4B ZRANB2 RBM6 HERC2 PRRC2A	7.16e-05	1497	74	12	31527615
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	ECM2 AGPAT1 ZRANB2 RBM6 SRSF9 PRRC2A HNRNPH3	9.08e-05	496	74	7	31343991
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BLM PLOD3 ZC3H4 PAXX EIF4B DUSP9 FGA	9.19e-05	497	74	7	36774506
Pubmed	CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.	SMURF1 SMURF2	9.31e-05	7	74	2	14701756
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	SMURF1 SMURF2	9.31e-05	7	74	2	30587574
Pubmed	SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.	SMURF1 SMURF2	9.31e-05	7	74	2	27292644
Pubmed	The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.	SMURF1 SMURF2	9.31e-05	7	74	2	28169289
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY2 ADCY6	9.31e-05	7	74	2	12613887
Pubmed	Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.	ZRANB2 HAPLN4 RBM6	1.00e-04	42	74	3	32738194
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	SMURF1 SMURF2	1.24e-04	8	74	2	19307600
Pubmed	Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.	SMURF1 SMURF2	1.24e-04	8	74	2	28881580
Pubmed	Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.	SMURF1 SMURF2	1.24e-04	8	74	2	20484049
Pubmed	Identification of NPM-ALK interacting proteins by tandem mass spectrometry.	MYLK EIF4B MAPK8IP3	1.40e-04	47	74	3	14968112
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY2 ADCY6	1.59e-04	9	74	2	17229090
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY2 ADCY6	1.59e-04	9	74	2	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY2 ADCY6	1.59e-04	9	74	2	12503609
Pubmed	Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella.	RSPH1 RSPH6A	1.59e-04	9	74	2	36417862
Pubmed	Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.	SMURF1 SMURF2	1.59e-04	9	74	2	29659741
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	ZC3H4 EIF4B PSMC2 PRRC2A HNRNPH3 DDX3X KHSRP	1.74e-04	551	74	7	34728620
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	PLOD3 FGA DDX3Y SRSF9 HNRNPH3 KHSRP	1.86e-04	390	74	6	17643375
Pubmed	Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).	SMURF1 SMURF2	1.99e-04	10	74	2	15221015
Pubmed	TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.	DDX3Y DDX3X	1.99e-04	10	74	2	18632687
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	SMURF1 SMURF2	1.99e-04	10	74	2	25092867
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY2 ADCY6	1.99e-04	10	74	2	8663304
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY2 ADCY6	1.99e-04	10	74	2	11884542
Pubmed	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.	SMURF1 SMURF2	1.99e-04	10	74	2	15138260
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY2 ADCY6	1.99e-04	10	74	2	16615126
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ZBTB45 EIF4B RBM6 PSMC2 TXLNG SRSF9 DDX3X KHSRP	2.01e-04	754	74	8	35906200
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	ZC3H4 DDX3Y HNRNPH3 KHSRP	2.08e-04	136	74	4	26979993
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BLM NSD2 RBM6 HERC2 TXLNG SRSF9 PRRC2A HNRNPH3	2.10e-04	759	74	8	35915203
Pubmed	Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.	EIF4B PRRC2A DDX3X	2.12e-04	54	74	3	25631074
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	ZC3H4 EIF4B ZRANB2 PSMC2 SRSF9 PRRC2A HNRNPH3 DDX3X KHSRP	2.16e-04	971	74	9	33306668
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	SMURF1 SMURF2	2.43e-04	11	74	2	17996703
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY2 ADCY6	2.43e-04	11	74	2	10089566
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	SMURF1 SMURF2	2.43e-04	11	74	2	22773947
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY2 ADCY6	2.43e-04	11	74	2	10808179
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY2 ADCY6	2.43e-04	11	74	2	11299302
Pubmed	Regulation of alternative splicing by SRrp86 and its interacting proteins.	ZRANB2 SRSF9 DDX3X	2.49e-04	57	74	3	14559993
Interaction	PTCH1 interactions	CELSR1 ABCA2 AGPAT1 ZRANB2 SMURF1 PSMC2 PRRC2A SMURF2	7.12e-06	273	74	8	int:PTCH1
Interaction	TOP3B interactions	CCDC71L PRR12 CELSR1 TNRC18 ABCA2 PLOD3 NSD2 KHNYN HERC2 TXLNG SRSF9 PRRC2A SMURF2 C8orf58 DDX3X PLEKHH3 MAPK8IP3	1.81e-05	1470	74	17	int:TOP3B
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	CCDC71L PLOD3 SMURF1 PSMC2	4.46e-04	219	74	4	chr7q22
Cytoband	3p21.3	CSPG5 RBM6	4.13e-03	59	74	2	3p21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	ZBTB39 EIF4B TAMALIN ADCY6	4.92e-03	423	74	4	chr12q13
Cytoband	12q13.13	EIF4B TAMALIN	5.30e-03	67	74	2	12q13.13
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	STX18 NSD2 ABLIM2	5.62e-03	222	74	3	chr4p16
Cytoband	17q21.2	KRT24 PLEKHH3	5.77e-03	70	74	2	17q21.2
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	MEF2D MSTO1	5.93e-03	71	74	2	chr1q22
GeneFamily	RNA binding motif containing	RBMXL2 RBMXL3 EIF4B RBM6 SRSF9 HNRNPH3	2.57e-05	213	50	6	725
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY2 ADCY6	3.33e-04	10	50	2	53
Drug	Thalidomide [50-35-1]; Up 200; 15.4uM; MCF7; HT_HG-U133A	HDAC11 CABP2 ABCA2 MYLK FGA ADCY6 DDX3X	3.25e-06	194	74	7	2258_UP
Drug	Bgs	BLM GALC GAS1 DDX3X	7.76e-06	39	74	4	CID009549182
Disease	childhood medulloblastoma (implicated_via_orthology)	DDX3Y DDX3X	5.39e-06	2	69	2	DOID:3869 (implicated_via_orthology)
Disease	Sertoli cell-only syndrome (implicated_via_orthology)	DDX3Y DDX3X	3.22e-05	4	69	2	DOID:0050457 (implicated_via_orthology)
Disease	disks large homolog 3 measurement	CCDC71L MEF2D	3.50e-04	12	69	2	EFO_0802472
Disease	noggin measurement	CCDC71L MEF2D	8.05e-04	18	69	2	EFO_0021995
Disease	Neurodevelopmental Disorders	ZC3H4 IQSEC2 DDX3X	1.37e-03	93	69	3	C1535926
Disease	Malignant neoplasm of breast	HK3 NSD2 HAPLN4 HERC2 ALS2CL PRRC2A PURG DDX3X	3.52e-03	1074	69	8	C0006142
Disease	hepatocyte growth factor-like protein measurement	RBM6 ALS2CL	3.59e-03	38	69	2	EFO_0008154

Protein segments in the cluster

Peptide	Gene	Start	Entry
GQRSGYGIEEDGDRG	ALS2CL	466	Q60I27
YGIEEDGDRGERYIG	ALS2CL	471	Q60I27
DYFEGLDGEGRGADL	CSPG5	211	O95196
GDYEVEPGRGGERNA	ADCY6	526	O43306
YNAGTDILEGDRLGG	HDAC11	256	Q96DB2
YGDGALEEARRLREG	BCL2L2	151	Q92843
AGDRQSYGEGDQDDR	ABLIM2	341	Q6H8Q1
RAFAVDGRDGAGEGL	C8orf58	6	Q8NAV2
RLLYTFQGGDDGDGD	CELSR1	926	Q9NYQ6
GEESGEGDRGGFNLY	PAXX	26	Q9BUH6
SGGRHEDSRLAGGYE	PLOD3	591	O60568
EEGAAGEGYLGRSSG	CACNA1F	1856	O60840
FDDRGRSDYDGIGSR	DDX3X	96	O00571
RSDYDGIGSRGDRSG	DDX3X	101	O00571
VGADGGGSDRYGSLR	MYLK	836	Q15746
LGAGEGLGERCYSEA	LRP10	321	Q7Z4F1
SGGEGYIDFRIGDGE	MAPK8IP3	1286	Q9UPT6
GKGRYGRLGHSDSED	HERC2	4116	O95714
GGGGRSGVRLEDFNY	GABBR1	486	Q9UBS5
RGQDGYSGETDAGGD	KATNIP	951	O60303
EDTYGAGDGLKRGAL	IQSEC2	1126	Q5JU85
EDGGASERERGGRPY	MKX	16	Q8IYA7
DGEAGRLEAFGQGES	MSTO1	186	Q9BUK6
EGDRGSRYQGVRGIG	NSD2	941	O96028
YDQGGGRRRRGEAEA	DUSP9	81	Q99956
EIETYRRLLDGEGGG	KRT24	441	Q2M2I5
YGNDGFDDRMRDGRG	HNRNPH3	161	P31942
DEDYDDEQRTGGAGG	GAS1	266	P54826
DGSERGDFLALDLGG	HK3	531	P52790
GGARRARGDADDAVY	TAMALIN	271	Q7Z6J2
GERDAGALGGAEDSL	NKX3-2	56	P78367
YLRDRSEEAAGGGDG	ADCY2	11	Q08462
EGYYQESGRAGRDGE	BLM	971	P54132
AGCGRGGDDYSEDEG	HAUS7	6	Q99871
ARGDEGAGYTDVYGD	ABCA2	1381	Q9BZC7
QGQLYSEGDSRGGDR	ECM2	236	O94769
DYKRGFGSLNDEGEG	FGA	691	P02671
ESEAGAGGERERRGA	MARCHF11	121	A6NNE9
RGARGDTYAVEKEGG	KHNYN	246	O15037
SYRGRAELQGDGPGD	HAPLN4	111	Q86UW8
RGGDFRAEDGAGLEA	CCDC71L	21	Q8N9Z2
DDRGRSDYDGIGNRE	DDX3Y	96	O15523
SDYDGIGNRERPGFG	DDX3Y	101	O15523
DDSDGLGREFDGIGA	GALC	46	P54803
DRDRDGYIGCRELGA	CABP2	91	Q9NPB3
GSYETGDRDDGRGDF	MEF2D	476	Q14814
EDYGEGDIEERRGGD	PURG	241	Q9UJV8
FGSGYRRDDDYRGGG	EIF4B	281	P23588
RDQGGFGDRNEYGSR	KHSRP	306	Q92945
FGDRNEYGSRIGGGI	KHSRP	311	Q92945
EGDEEEEGGAGRDSY	RSPH6A	506	Q9H0K4
EIDAIGGARFDDGAG	PSMC2	276	P35998
RGGDGTSMDYRGREA	RBM6	136	P78332
GSRGALGEKEDRGEY	SOX7	151	Q9BT81
HRDYGDGELSGDGDE	PLEKHH3	21	Q7Z736
DERGGEGDGRIYVGN	SRSF9	6	Q13242
SYREFRGDDGRGGGT	PRRC2A	1056	P48634
DIGEYEGGRNEAGER	RSPH1	16	Q8WYR4
GESGGEGIFRERDEF	PRR12	1566	Q9ULL5
DGYGGRDRDYGDHLS	RBMXL2	261	O75526
KFRGEEGLDYGGVAR	SMURF1	431	Q9HCE7
RAARGEGSRGGAEDE	ZCCHC2	206	Q9C0B9
FRGEEGLDYGGVARE	SMURF2	426	Q9HAU4
LEEEDEASGGGYRLG	TNRC18	1836	O15417
GLADYSGAGRDFLRG	ZBTB45	261	Q96K62
GGGRYEEYRGRSLDA	RBMXL3	626	Q8N7X1
DGGYELGDLARGFRG	PLPPR3	616	Q6T4P5
VFREISTDGRGGGDY	AGPAT1	261	Q99943
AVGGGVDGSRDELFR	STX18	26	Q9P2W9
EREEDYGREGGSAEA	STYXL2	281	Q5VZP5
YGREGGSAEAEEGEG	STYXL2	286	Q5VZP5
QFGDEGELEAGRGSR	CREBZF	56	Q9NS37
ELEFRGGGGEARLES	TBC1D30	16	Q9Y2I9
EDMGDGGGGSYRSRD	ZC3H4	366	Q9UPT8
LGELRGGGDYLGADR	ZBTB39	156	O15060
LEERTGYGGGFNERE	ZRANB2	96	O95218
LGDRLPAGDDGYSGA	ZNF648	141	Q5T619
EEAARGRGGGAEEAT	TXLNG	6	Q9NUQ3
DGGANRLYDITEGER	TPK1	46	Q9H3S4