Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cellular response to tumor cell	NOTCH1 NOTCH2	2.41e-05	3	59	2	GO:0071228
GeneOntologyBiologicalProcess	Notch signaling pathway	LLGL2 CBFA2T2 GMDS HIF1AN NOTCH1 NOTCH2	2.98e-05	210	59	6	GO:0007219
GeneOntologyBiologicalProcess	positive regulation of synapse structural plasticity	CAMK1 SHANK3	4.81e-05	4	59	2	GO:0051835
GeneOntologyBiologicalProcess	nuclear migration along microtubule	TRIM58 SUN1	8.00e-05	5	59	2	GO:0030473
GeneOntologyBiologicalProcess	endocardial cell differentiation	SOX17 NOTCH1	1.20e-04	6	59	2	GO:0060956
GeneOntologyBiologicalProcess	regulation of grooming behavior	SHANK3 NMU	1.20e-04	6	59	2	GO:2000821
GeneOntologyBiologicalProcess	nuclear migration	TRIM58 SUN1 DYNC1H1	1.25e-04	34	59	3	GO:0007097
GeneOntologyBiologicalProcess	response to auditory stimulus	USP53 ABHD12 SHANK3	1.61e-04	37	59	3	GO:0010996
GeneOntologyBiologicalProcess	endocardium morphogenesis	SOX17 NOTCH1	1.67e-04	7	59	2	GO:0003160
GeneOntologyBiologicalProcess	common bile duct development	SOX17 NOTCH2	2.23e-04	8	59	2	GO:0061009
GeneOntologyBiologicalProcess	cardiac endothelial cell differentiation	SOX17 NOTCH1	2.23e-04	8	59	2	GO:0003348
GeneOntologyBiologicalProcess	nucleus localization	TRIM58 SUN1 DYNC1H1	2.71e-04	44	59	3	GO:0051647
GeneOntologyBiologicalProcess	positive regulation of neuroblast proliferation	SOX10 NOTCH1 NOTCH2	2.71e-04	44	59	3	GO:0002052
GeneOntologyBiologicalProcess	atrioventricular node development	NOTCH1 NOTCH2	2.86e-04	9	59	2	GO:0003162
GeneOntologyBiologicalProcess	base-excision repair	LIG3 PARG USP47	3.09e-04	46	59	3	GO:0006284
GeneOntologyBiologicalProcess	regulation of Notch signaling pathway	LLGL2 CBFA2T2 HIF1AN NOTCH1	3.19e-04	114	59	4	GO:0008593
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	SOX10 FREM2 LLGL2 MTHFR SOX17 SHANK3 NOTCH1 NOTCH2	3.62e-04	619	59	8	GO:0002009
GeneOntologyBiologicalProcess	regulation of synapse structural plasticity	CAMK1 SHANK3	5.21e-04	12	59	2	GO:0051823
GeneOntologyBiologicalProcess	methionine biosynthetic process	MTHFR MTR	5.21e-04	12	59	2	GO:0009086
GeneOntologyBiologicalProcess	foregut morphogenesis	SOX17 NOTCH1	5.21e-04	12	59	2	GO:0007440
MousePheno	abnormal magnesium level	SLC12A3 GMDS TRRAP KLHL18	2.95e-05	49	51	4	MP:0020883
MousePheno	abnormal circulating magnesium level	SLC12A3 GMDS TRRAP KLHL18	2.95e-05	49	51	4	MP:0001771
MousePheno	abnormal magnesium ion homeostasis	SLC12A3 GMDS TRRAP KLHL18	3.20e-05	50	51	4	MP:0011979
MousePheno	increased testis apoptosis	SUN1 CFAP61 C3orf20	5.81e-05	21	51	3	MP:0013601
MousePheno	abnormal testis apoptosis	SUN1 CFAP61 C3orf20	5.81e-05	21	51	3	MP:0031353
Domain	-	SOX3 SOX10 CCDC124 SOX17 SOX13	8.16e-07	55	59	5	1.10.30.10
Domain	HMG_box_dom	SOX3 SOX10 CCDC124 SOX17 SOX13	1.89e-06	65	59	5	IPR009071
Domain	HMG_box	SOX3 SOX10 SOX17 SOX13	2.34e-05	53	59	4	PF00505
Domain	HMG_BOX_2	SOX3 SOX10 SOX17 SOX13	2.52e-05	54	59	4	PS50118
Domain	HMG	SOX3 SOX10 SOX17 SOX13	2.52e-05	54	59	4	SM00398
Domain	DUF3454	NOTCH1 NOTCH2	2.94e-05	3	59	2	PF11936
Domain	DUF3454_notch	NOTCH1 NOTCH2	2.94e-05	3	59	2	IPR024600
Domain	DUF3454	NOTCH1 NOTCH2	2.94e-05	3	59	2	SM01334
Domain	Notch	NOTCH1 NOTCH2	5.86e-05	4	59	2	IPR008297
Domain	NODP	NOTCH1 NOTCH2	5.86e-05	4	59	2	PF07684
Domain	Notch_NODP_dom	NOTCH1 NOTCH2	5.86e-05	4	59	2	IPR011656
Domain	Notch_NOD_dom	NOTCH1 NOTCH2	5.86e-05	4	59	2	IPR010660
Domain	NOD	NOTCH1 NOTCH2	5.86e-05	4	59	2	PF06816
Domain	NOD	NOTCH1 NOTCH2	5.86e-05	4	59	2	SM01338
Domain	NODP	NOTCH1 NOTCH2	5.86e-05	4	59	2	SM01339
Domain	LNR	NOTCH1 NOTCH2	9.75e-05	5	59	2	PS50258
Domain	Notch_dom	NOTCH1 NOTCH2	2.04e-04	7	59	2	IPR000800
Domain	Notch	NOTCH1 NOTCH2	2.04e-04	7	59	2	PF00066
Domain	NL	NOTCH1 NOTCH2	2.04e-04	7	59	2	SM00004
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DYNC1H1	8.71e-04	14	59	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DYNC1H1	8.71e-04	14	59	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DYNC1H1	8.71e-04	14	59	2	IPR013602
Domain	DHC_N2	DNAH3 DYNC1H1	8.71e-04	14	59	2	PF08393
Domain	MT	DNAH3 DYNC1H1	8.71e-04	14	59	2	PF12777
Domain	AAA_8	DNAH3 DYNC1H1	8.71e-04	14	59	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH3 DYNC1H1	8.71e-04	14	59	2	IPR011704
Domain	AAA_5	DNAH3 DYNC1H1	8.71e-04	14	59	2	PF07728
Domain	DHC_fam	DNAH3 DYNC1H1	1.00e-03	15	59	2	IPR026983
Domain	Dynein_heavy_dom	DNAH3 DYNC1H1	1.00e-03	15	59	2	IPR004273
Domain	Dynein_heavy	DNAH3 DYNC1H1	1.00e-03	15	59	2	PF03028
Domain	hEGF	NOTCH1 NOTCH2	3.52e-03	28	59	2	PF12661
Domain	Ank_2	POTEH SHANK3 NOTCH1 NOTCH2	4.74e-03	215	59	4	PF12796
Pathway	REACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3	NOTCH1 NOTCH2	9.04e-05	5	43	2	M27411
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	SOX3 SOX17 SOX13	1.23e-04	32	43	3	MM14975
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM	NOTCH1 NOTCH2	1.35e-04	6	43	2	M27068
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	SOX3 SOX17 SOX13	2.79e-04	42	43	3	M27272
Pathway	WP_FOLATEALCOHOL_AND_CANCER_PATHWAY_HYPOTHESES	MTHFR MTR	3.23e-04	9	43	2	M39396
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION	NOTCH1 NOTCH2	4.91e-04	11	43	2	M47865
Pathway	BIOCARTA_HES_PATHWAY	NOTCH1 NOTCH2	5.88e-04	12	43	2	MM1562
Pathway	BIOCARTA_HES_PATHWAY	NOTCH1 NOTCH2	5.88e-04	12	43	2	M22042
Pathway	WP_SPINA_BIFIDA	MTHFR MTR	5.88e-04	12	43	2	M48321
Pathway	REACTOME_SPECIFICATION_OF_PRIMORDIAL_GERM_CELLS	CBFA2T2 SOX17	5.88e-04	12	43	2	M48035
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	NOTCH1 NOTCH2	5.88e-04	12	43	2	M47532
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381	NOTCH1 NOTCH2	5.88e-04	12	43	2	M47533
Pathway	WP_ONECARBON_METABOLISM_AND_RELATED_PATHWAYS	MTHFR MTR PLD1	5.88e-04	54	43	3	MM15848
Pathway	WP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION	SOX10 SOX17 SHANK3 NOTCH1	6.83e-04	132	43	4	M48110
Pathway	KEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY	NOTCH1 NOTCH2	6.94e-04	13	43	2	M47423
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	NOTCH1 NOTCH2	6.94e-04	13	43	2	M47534
Pathway	WP_HYPOXIADEPENDENT_DIFFERENTIATION_OF_MYOBLASTS	HIF1AN NOTCH1	6.94e-04	13	43	2	MM15894
Pathway	WP_TRANSSULFURATION_ONECARBON_METABOLISM_AND_RELATED_PATHWAYS	MTHFR MTR PLD1	1.11e-03	67	43	3	M39710
Pathway	KEGG_ONE_CARBON_POOL_BY_FOLATE	MTHFR MTR	1.20e-03	17	43	2	M12039
Pathway	REACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT	SOX3 SOX17 TRRAP SOX13	1.33e-03	158	43	4	MM14791
Pathway	REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI	NOTCH1 NOTCH2	1.35e-03	18	43	2	M614
Pathway	WP_DISORDERS_OF_FOLATE_METABOLISM_AND_TRANSPORT	MTHFR MTR	1.50e-03	19	43	2	M39777
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	NOTCH1 NOTCH2	1.67e-03	20	43	2	M27881
Pathway	WP_FOLIC_ACID_NETWORK	MTHFR MTR	2.02e-03	22	43	2	MM15955
Pubmed	Spatio-temporal expression of Sox genes in murine palatogenesis.	SOX3 SOX10 SOX17 SOX13	2.00e-08	17	61	4	27241892
Pubmed	Expression of Sox genes in tooth development.	SOX3 SOX10 SOX17 SOX13	2.57e-08	18	61	4	26864488
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	LIG3 ZC3H11A CBFA2T2 CHAF1A PARG DDX39A TRRAP HIF1AN DYNC1H1 NOTCH1 NOTCH2 USP47	2.67e-08	857	61	12	25609649
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	LIG3 CHTF18 CHAF1A PARG DDX39A NOTCH1 USP47	3.42e-08	183	61	7	36129980
Pubmed	Expression of Sox transcription factors in the developing mouse pancreas.	SOX3 SOX10 SOX17 SOX13	5.01e-08	21	61	4	12815626
Pubmed	Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.	HIF1AN NOTCH1 NOTCH2	1.02e-07	6	61	3	18299578
Pubmed	SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch.	SOX3 SOX10 NOTCH1 NOTCH2	2.60e-07	31	61	4	19723505
Pubmed	Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.	HIF1AN NOTCH1 NOTCH2	4.28e-07	9	61	3	17573339
Pubmed	From head to toes: the multiple facets of Sox proteins.	SOX3 SOX10 SOX13	6.11e-07	10	61	3	10037800
Pubmed	Notch signaling promotes nephrogenesis by downregulating Six2.	SLC12A3 NOTCH1 NOTCH2	1.12e-06	12	61	3	27633993
Pubmed	Seven new members of the Sox gene family expressed during mouse development.	SOX3 SOX10 SOX13	1.45e-06	13	61	3	8441686
Pubmed	Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.	SOX3 SOX17 SOX13	1.45e-06	13	61	3	12194848
Pubmed	Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth.	SOX10 SOX17 SOX13	1.84e-06	14	61	3	8921394
Pubmed	Differential isoform expression and alternative splicing in sex determination in mice.	SOX3 SOX10 SOX13	2.30e-06	15	61	3	30871468
Pubmed	Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture.	NOTCH1 NOTCH2	3.03e-06	2	61	2	24508387
Pubmed	Methylenetetrahydrofolate reductase and methionine synthase polymorphisms and risk of bladder cancer in a Tunisian population.	MTHFR MTR	3.03e-06	2	61	2	17574963
Pubmed	Notch controls generation and function of human effector CD8+ T cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	23380742
Pubmed	Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects.	MTHFR MTR	3.03e-06	2	61	2	11186937
Pubmed	ANALYSIS OF RELATIONSHIP BETWEEN POLYMORPHISM OF MTHFR (C677T), MTHFR (A1298C), MTR (A2756G) GENES IN THE DEVELOPMENT OF ISCHEMIC STROKE IN YOUNG PATIENTS.	MTHFR MTR	3.03e-06	2	61	2	34749329
Pubmed	Methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma.	MTHFR MTR	3.03e-06	2	61	2	15551285
Pubmed	Differential Notch1 and Notch2 expression and frequent activation of Notch signaling in gastric cancers.	NOTCH1 NOTCH2	3.03e-06	2	61	2	21466361
Pubmed	Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice.	NOTCH1 NOTCH2	3.03e-06	2	61	2	20069650
Pubmed	Testosterone influenced the expression of Notch1, Notch2 and Jagged1 induced by lipopolysaccharide in macrophages.	NOTCH1 NOTCH2	3.03e-06	2	61	2	15625786
Pubmed	Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population.	MTHFR MTR	3.03e-06	2	61	2	12111380
Pubmed	Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan.	MTHFR MTR	3.03e-06	2	61	2	19838916
Pubmed	Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta.	MTHFR MTR	3.03e-06	2	61	2	25277375
Pubmed	Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma.	MTHFR MTR	3.03e-06	2	61	2	11342450
Pubmed	Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.	MTHFR MTR	3.03e-06	2	61	2	19389261
Pubmed	Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.	NOTCH1 NOTCH2	3.03e-06	2	61	2	17261636
Pubmed	Motch A and motch B--two mouse Notch homologues coexpressed in a wide variety of tissues.	NOTCH1 NOTCH2	3.03e-06	2	61	2	8440332
Pubmed	MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study.	MTHFR MTR	3.03e-06	2	61	2	23595572
Pubmed	Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis.	MTHFR MTR	3.03e-06	2	61	2	18815869
Pubmed	Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease.	MTHFR MTR	3.03e-06	2	61	2	19283448
Pubmed	Differential expression of Notch1 and Notch2 in developing and adult mouse brain.	NOTCH1 NOTCH2	3.03e-06	2	61	2	7609614
Pubmed	Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism.	MTHFR MTR	3.03e-06	2	61	2	11920232
Pubmed	MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis.	MTHFR MTR	3.03e-06	2	61	2	28081209
Pubmed	Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.	NOTCH1 NOTCH2	3.03e-06	2	61	2	33017398
Pubmed	Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	21285514
Pubmed	Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.	NOTCH1 NOTCH2	3.03e-06	2	61	2	18353145
Pubmed	Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation.	NOTCH1 NOTCH2	3.03e-06	2	61	2	22205705
Pubmed	Notch signaling induces cell cycle arrest in small cell lung cancer cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	11306509
Pubmed	Correlation of asymmetric Notch2 expression and mouse incisor rotation.	NOTCH1 NOTCH2	3.03e-06	2	61	2	10704869
Pubmed	Notch signaling is necessary but not sufficient for differentiation of dendritic cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	12907456
Pubmed	Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea.	MTHFR MTR	3.03e-06	2	61	2	26833750
Pubmed	Colorectal cancer and the methylenetetrahydrofolate reductase 677C -> T and methionine synthase 2756A -> G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort.	MTHFR MTR	3.03e-06	2	61	2	15598777
Pubmed	Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration.	NOTCH1 NOTCH2	3.03e-06	2	61	2	23589286
Pubmed	Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.	MTHFR MTR	3.03e-06	2	61	2	27173331
Pubmed	Inhibition of granulocytic differentiation by mNotch1.	NOTCH1 NOTCH2	3.03e-06	2	61	2	8917536
Pubmed	Association of methylenetetrahydrofolate reductase and methionine synthase polymorphisms with breast cancer risk and interaction with folate, vitamin B6, and vitamin B 12 intakes.	MTHFR MTR	3.03e-06	2	61	2	25217320
Pubmed	Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study.	MTHFR MTR	3.03e-06	2	61	2	15117811
Pubmed	Functional conservation of Notch1 and Notch2 intracellular domains.	NOTCH1 NOTCH2	3.03e-06	2	61	2	15897231
Pubmed	Increased surface expression of NOTCH on memory T cells in peripheral blood from patients with asthma.	NOTCH1 NOTCH2	3.03e-06	2	61	2	30296524
Pubmed	Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	12753746
Pubmed	Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia.	MTHFR MTR	3.03e-06	2	61	2	19034339
Pubmed	Impact of methionine synthase gene and methylenetetrahydrofolate reductase gene polymorphisms on the risk of sudden sensorineural hearing loss.	MTHFR MTR	3.03e-06	2	61	2	16778415
Pubmed	Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study.	MTHFR MTR	3.03e-06	2	61	2	21385350
Pubmed	Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL.	NOTCH1 NOTCH2	3.03e-06	2	61	2	26041884
Pubmed	Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis.	MTHFR MTR	3.03e-06	2	61	2	25052622
Pubmed	The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer.	NOTCH1 NOTCH2	3.03e-06	2	61	2	15492845
Pubmed	Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients.	MTHFR MTR	3.03e-06	2	61	2	20445573
Pubmed	Unravelling disparate roles of NOTCH in bladder cancer.	NOTCH1 NOTCH2	3.03e-06	2	61	2	29643502
Pubmed	Low folate status, and MTHFR 677C > T and MTR 2756A > G polymorphisms associated with colorectal cancer risk in Thais: a case-control study.	MTHFR MTR	3.03e-06	2	61	2	31740010
Pubmed	Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk.	MTHFR MTR	3.03e-06	2	61	2	19706843
Pubmed	Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women.	MTHFR MTR	3.03e-06	2	61	2	11584084
Pubmed	Interaction of MTHFR C677T and A1298C, and MTR A2756G gene polymorphisms in breast cancer risk in a population in Northeast Brazil.	MTHFR MTR	3.03e-06	2	61	2	23155246
Pubmed	Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro.	NOTCH1 NOTCH2	3.03e-06	2	61	2	31316119
Pubmed	Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer.	MTHFR MTR	3.03e-06	2	61	2	25366783
Pubmed	A role for notch signaling in human corneal epithelial cell differentiation and proliferation.	NOTCH1 NOTCH2	3.03e-06	2	61	2	17652726
Pubmed	Clinical role of Notch signaling pathway in intraductal papillary mucinous neoplasm of the pancreas.	NOTCH1 NOTCH2	3.03e-06	2	61	2	25041344
Pubmed	Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	25866967
Pubmed	Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking.	NOTCH1 NOTCH2	3.03e-06	2	61	2	32423029
Pubmed	The allele frequencies of three polymorphisms in genes involved in homocysteine metabolism in a group of unrelated healthy Singaporeans.	MTHFR MTR	3.03e-06	2	61	2	21045271
Pubmed	Notch2 signaling is required for potent antitumor immunity in vivo.	NOTCH1 NOTCH2	3.03e-06	2	61	2	20351182
Pubmed	Polymorphisms in one-carbon metabolism pathway genes, urinary arsenic profile, and urothelial carcinoma.	MTHFR MTR	3.03e-06	2	61	2	20532609
Pubmed	Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: A study from Jammu region.	MTHFR MTR	3.03e-06	2	61	2	27316508
Pubmed	Involvement of Notch in activation and effector functions of γδ T cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	24489102
Pubmed	Association between MTHFR C677T, MTHFR A1298C and MS A2756G polymorphisms and risk of cervical intraepithelial neoplasia II/III and cervical cancer: a meta-analysis.	MTHFR MTR	3.03e-06	2	61	2	23864153
Pubmed	Genetic polymorphism of folate and methionine metabolizing enzymes and their susceptibility to malignant lymphoma.	MTHFR MTR	3.03e-06	2	61	2	16799656
Pubmed	Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.	MTHFR MTR	3.03e-06	2	61	2	17339646
Pubmed	Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level.	MTHFR MTR	3.03e-06	2	61	2	24103477
Pubmed	The Notch pathway in podocytes plays a role in the development of glomerular disease.	NOTCH1 NOTCH2	3.03e-06	2	61	2	18311147
Pubmed	Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan.	MTHFR MTR	3.03e-06	2	61	2	15790587
Pubmed	Recurrent mutations of NOTCH genes in follicular lymphoma identify a distinctive subset of tumours.	NOTCH1 NOTCH2	3.03e-06	2	61	2	25141821
Pubmed	"Association of MTHFR and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case-control study encompassing meta-analysis and trial sequential analysis".	MTHFR MTR	3.03e-06	2	61	2	35468734
Pubmed	Methylene tetrahydrofolate reductase and methionine synthase gene polymorphisms as genetic determinants of pre-eclampsia.	MTHFR MTR	3.03e-06	2	61	2	32120336
Pubmed	DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR.	MTHFR MTR	3.03e-06	2	61	2	19240236
Pubmed	Low frequency of mutated methylenetetrahydrofolate reductase 677C-->T and 1298A-->C genetics single nucleotide polymorphisms (SNPs) in Sub-Saharan populations.	MTHFR MTR	3.03e-06	2	61	2	12964809
Pubmed	Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis.	NOTCH1 NOTCH2	3.03e-06	2	61	2	26933171
Pubmed	Association of MTHFR 677C > T, 1298A > C and MTR 2756A > G Polymorphisms with Susceptibility to Childhood Retinoblastoma: A Systematic Review and Met-Analysis.	MTHFR MTR	3.03e-06	2	61	2	32064992
Pubmed	A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.	NOTCH1 NOTCH2	3.03e-06	2	61	2	21693515
Pubmed	Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.	MTHFR MTR	3.03e-06	2	61	2	15820491
Pubmed	Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma.	MTHFR MTR	3.03e-06	2	61	2	12648076
Pubmed	Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis.	NOTCH1 NOTCH2	3.03e-06	2	61	2	27564686
Pubmed	Notch down-regulation in regenerated epidermis contributes to enhanced expression of interleukin-36α and suppression of keratinocyte differentiation during wound healing.	NOTCH1 NOTCH2	3.03e-06	2	61	2	25982147
Pubmed	Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.	NOTCH1 NOTCH2	3.03e-06	2	61	2	19701457
Pubmed	Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.	NOTCH1 NOTCH2	3.03e-06	2	61	2	28820917
Pubmed	Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.	NOTCH1 NOTCH2	3.03e-06	2	61	2	22006338
Pubmed	Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cells.	NOTCH1 NOTCH2	3.03e-06	2	61	2	19339697
Pubmed	Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians.	MTHFR MTR	3.03e-06	2	61	2	27097558
Pubmed	Interaction between maternal 5,10-methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene variants to increase the risk of fetal neural tube defects in a Shanxi Han population.	MTHFR MTR	3.03e-06	2	61	2	23489792
Interaction	PPP1R12B interactions	GMDS ACAD10 HIF1AN NOTCH1 NOTCH2 USP47	5.65e-08	68	61	6	int:PPP1R12B
Interaction	NOTCH3 interactions	CBFA2T2 HIF1AN SHANK3 NOTCH1 NOTCH2	2.35e-05	113	61	5	int:NOTCH3
Interaction	CCN6 interactions	NOTCH1 NOTCH2 NMU	2.47e-05	19	61	3	int:CCN6
GeneFamily	SRY-boxes	SOX3 SOX10 SOX17 SOX13	1.26e-07	19	45	4	757
ToppCell	PND07-28-samps-Endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SOX17 SOX13 DENND2B SHANK3 NOTCH1	6.10e-06	189	61	5	eb2f8c8a90e5e9f6697a2d13274c94f40e1973e4
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SOX17 SOX13 DENND2B SHANK3 NOTCH1	6.10e-06	189	61	5	d4a25d59d88325d3b20f4287e9b1160c82961a96
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX3 SOX10 CHTF18 ACAD10	2.46e-05	123	61	4	e0eb95f1da12687230b47f0a7367b6138bc7ff1a
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX3 SOX10 CHTF18 ACAD10	2.46e-05	123	61	4	356e2b1b47fdfc2bb2fcd45e44b452fe811f0fd8
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX3 SOX10 CHTF18 ACAD10	2.46e-05	123	61	4	15f951b4eb2f39888e51e1af18c329953d253f7f
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1-Polydendrocyte.Tnr.Tnr_(Tnr)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX3 SOX10 CHTF18 ACAD10	2.46e-05	123	61	4	b06a38d1081b4485b519853d8c9a2cddfb1e9e75
ToppCell	Cerebellum-Macroglia-POLYDENDROCYTE-P1-P1_1-Polydendrocyte.Tnr.Tnr_(Tnr)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SOX3 SOX10 CHTF18 ACAD10	2.46e-05	123	61	4	f60c1dd89da0e204f73772fe0c319eeca82e7e8a
Computational	Neighborhood of MSH2	CHAF1A PARG DDX39A TRRAP	6.00e-05	61	38	4	MORF_MSH2
Drug	AC1NRBPT	SOX3 SOX10 MTHFR MTR PLD1 CIT	4.31e-06	162	60	6	CID005288571
Disease	obsolete_red blood cell distribution width	ZC3H11A POLR1A GALNT2 TRIM58 MTHFR CBFA2T2 CHAF1A SUN1 PLD1 EXOC3L2 CIT DENND2B NOTCH1 USP47	1.94e-07	1347	57	14	EFO_0005192
Disease	Lymphoma	MTHFR MTR NOTCH1 NOTCH2	1.09e-06	40	57	4	C0024299
Disease	Peripheral demyelinating neuropathy	SOX10 ABHD12	3.67e-06	2	57	2	C0270922
Disease	Malnutrition	MTHFR MTR	1.10e-05	3	57	2	C0162429
Disease	hyperhomocysteinemia (is_implicated_in)	MTHFR MTR	1.10e-05	3	57	2	DOID:9279 (is_implicated_in)
Disease	brain cancer (implicated_via_orthology)	LLGL2 NOTCH1 NOTCH2	1.72e-05	26	57	3	DOID:1319 (implicated_via_orthology)
Disease	Neural tube defects, folate-sensitive	MTHFR MTR	2.19e-05	4	57	2	cv:C1866558
Disease	Neural tube defect, folate-sensitive	MTHFR MTR	2.19e-05	4	57	2	C1866558
Disease	NEURAL TUBE DEFECTS, FOLATE-SENSITIVE	MTHFR MTR	2.19e-05	4	57	2	601634
Disease	cervical cancer	MTHFR NOTCH1 NOTCH2	3.92e-05	34	57	3	C4048328
Disease	Uterine Cervical Neoplasm	MTHFR NOTCH1 NOTCH2	4.28e-05	35	57	3	C0007873
Disease	red blood cell density measurement	POLR1A TRIM58 MTHFR ZC3H11B GMDS ACAD10 EXOC3L2 DENND2B ITIH3	4.47e-05	880	57	9	EFO_0007978
Disease	spina bifida (is_implicated_in)	MTHFR MTR	5.47e-05	6	57	2	DOID:0080016 (is_implicated_in)
Disease	adenocarcinoma (implicated_via_orthology)	NOTCH1 NOTCH2	7.65e-05	7	57	2	DOID:299 (implicated_via_orthology)
Disease	central nervous system cancer (implicated_via_orthology)	NOTCH1 NOTCH2	7.65e-05	7	57	2	DOID:3620 (implicated_via_orthology)
Disease	Hematological Disease	MTHFR MTR	1.02e-04	8	57	2	C0018939
Disease	mean reticulocyte volume	POLR1A TRIM58 MTHFR CHTF18 CHAF1A SNX10 EXOC3L2 TRRAP	1.43e-04	799	57	8	EFO_0010701
Disease	Leukoencephalopathy	MTHFR MTR	1.99e-04	11	57	2	C0270612
Disease	open-angle glaucoma (is_implicated_in)	MTHFR GMDS	2.39e-04	12	57	2	DOID:1067 (is_implicated_in)
Disease	Gastrointestinal Diseases	MTHFR MTR	2.39e-04	12	57	2	C0017178
Disease	Functional Gastrointestinal Disorders	MTHFR MTR	2.39e-04	12	57	2	C0559031
Disease	Cholera Infantum	MTHFR MTR	2.39e-04	12	57	2	C1565321
Disease	Childhood Ataxia with Central Nervous System Hypomyelinization	MTHFR MTR	3.29e-04	14	57	2	C1858991
Disease	Lymphoma, Large-Cell, Follicular	MTHFR MTR	3.79e-04	15	57	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	MTHFR MTR	3.79e-04	15	57	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	MTHFR MTR	3.79e-04	15	57	2	C0079758
Disease	Neoplasm of uncertain or unknown behavior of bladder	NOTCH1 NOTCH2	3.79e-04	15	57	2	C0496930
Disease	Lymphoma, Follicular, Grade 2	MTHFR MTR	3.79e-04	15	57	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	MTHFR MTR	3.79e-04	15	57	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	MTHFR MTR	3.79e-04	15	57	2	C1956130
Disease	Benign neoplasm of bladder	NOTCH1 NOTCH2	3.79e-04	15	57	2	C0154017
Disease	Carcinoma in situ of bladder	NOTCH1 NOTCH2	3.79e-04	15	57	2	C0154091
Disease	response to acetylsalicylate	KIF9 KLHL18	4.32e-04	16	57	2	GO_1903492
Disease	Vascular Diseases	SLC12A3 MTHFR	4.89e-04	17	57	2	C0042373
Disease	Mammary Carcinoma, Human	ZC3H11A LLGL2 MTHFR MTR NOTCH1 NOTCH2	5.19e-04	525	57	6	C4704874
Disease	Mammary Neoplasms, Human	ZC3H11A LLGL2 MTHFR MTR NOTCH1 NOTCH2	5.19e-04	525	57	6	C1257931
Disease	Mammary Neoplasms	ZC3H11A LLGL2 MTHFR MTR NOTCH1 NOTCH2	5.29e-04	527	57	6	C1458155
Disease	Carcinoma of bladder	NOTCH1 NOTCH2	5.50e-04	18	57	2	C0699885
Disease	Schizophrenia	MTHFR SHANK3	5.50e-04	18	57	2	cv:C0036341
Disease	Breast Carcinoma	ZC3H11A LLGL2 MTHFR MTR NOTCH1 NOTCH2	5.90e-04	538	57	6	C0678222
Disease	Lymphoma, Follicular	MTHFR MTR	6.81e-04	20	57	2	C0024301
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	LLGL2 GALNT2 ZC3H11B ITIH3	9.32e-04	224	57	4	EFO_0004530, EFO_0008317
Disease	Cerebral Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0750935
Disease	Intracranial Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0750936
Disease	Pilocytic Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0334583
Disease	Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0280783
Disease	Diffuse Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0280785
Disease	Grade I Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0205768
Disease	Mixed oligoastrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0547065
Disease	Childhood Cerebral Astrocytoma	NOTCH1 NOTCH2	1.07e-03	25	57	2	C0338070
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement, age at assessment	SNX10 ZC3H11B NMU	1.11e-03	105	57	3	EFO_0007788, EFO_0008007, EFO_0008343
Disease	Kallmann Syndrome	SOX3 SOX10	1.16e-03	26	57	2	C0162809
Disease	Gemistocytic astrocytoma	NOTCH1 NOTCH2	1.16e-03	26	57	2	C0334581
Disease	Protoplasmic astrocytoma	NOTCH1 NOTCH2	1.16e-03	26	57	2	C0334580
Disease	Fibrillary Astrocytoma	NOTCH1 NOTCH2	1.16e-03	26	57	2	C0334582
Disease	fibrinogen measurement	GALNT2 ACAD10 SHANK3	1.24e-03	109	57	3	EFO_0004623
Disease	Anaplastic astrocytoma	NOTCH1 NOTCH2	1.25e-03	27	57	2	C0334579
Disease	pancreatic cancer (is_implicated_in)	LIG3 MTHFR MTR	1.34e-03	112	57	3	DOID:1793 (is_implicated_in)
Disease	body surface area	TRIM66 POLR1A ZC3H11B GMDS ACAD10 HIF1AN	1.48e-03	643	57	6	EFO_0022196
Disease	colorectal cancer (implicated_via_orthology)	NOTCH1 NOTCH2	1.54e-03	30	57	2	DOID:9256 (implicated_via_orthology)
Disease	intestinal cancer (implicated_via_orthology)	NOTCH1 NOTCH2	1.75e-03	32	57	2	DOID:10155 (implicated_via_orthology)
Disease	Alcoholic Intoxication	MTHFR MTR	1.75e-03	32	57	2	C0001969

Protein segments in the cluster

Peptide	Gene	Start	Entry
QRVERFHENPAVREM	EXOC3L2	101	Q2M3D2
HIMRRAAREEQPEKD	CHTF18	901	Q8WVB6
RKARVEDHDDLMPIF	CFAP61	186	Q8NHU2
GERKFHRIIMEDERI	CXorf58	151	Q96LI9
MRRDVQEIFRLTPHE	DDX39A	206	O00148
EVRFEHVRVPKENMV	ACAD10	886	Q6JQN1
FEIKEHMVLAPRRRT	CHAF1A	471	Q13111
LRRPMDSRLEHVDFE	DENND2B	861	P78524
PEEFSRRLKERMHHN	CIT	1346	O14578
MRKRTEPVALEHERC	ABHD12	1	Q8N2K0
MDDPKSEQQRILRRH	OTUD6A	1	Q7L8S5
RDITDHMDRLPRDVA	NOTCH2	2036	Q04721
GLDPERHERLREKMR	MTHFR	36	P42898
DHMDRLPRDIAQERM	NOTCH1	2091	P46531
QRLPEEARHRRVFEM	LLGL2	176	Q6P1M3
VPHLHERRMKRFRVD	NMU	131	P48645
KPRVAFDELVREMVH	GMDS	346	O60547
PRSNREEMKFHEFVE	HIF1AN	116	Q9NWT6
REMREAFTVHLKPDE	FREM2	2331	Q5SZK8
KLRMDRAIPDTRHDQ	GALNT2	111	Q10471
ERPKMFEELGQRLQH	HSPH1	711	Q92598
REPNKMLEHREVRDR	CBFA2T2	306	O43439
TDHFMRLPKAEDRRK	PARG	411	Q86W56
VRVKPTDDFAHEMIR	KIF9	11	Q9HAQ2
MDRPLCERRKFLHDN	LIG3	606	P49916
CERRKFLHDNMVEIP	LIG3	611	P49916
DFIRHLMEKDPEKRF	CAMK1	251	Q14012
LVDEAKDYHLMPERR	KLHL18	256	O94889
MKRIRERFINHPEFQ	DNAH3	2856	Q8TD57
EEEFVRFKMRSRTHP	C3orf20	576	Q8ND61
HKDIQMPDGIRREEF	DYNC1H1	4291	Q14204
RHREPQEDLRKELMD	IGFN1	131	Q86VF2
SEALVDPERRDHRMN	FAM183BP	96	Q6ZVS7
PAEHVERFFEKMDRN	KCNIP3	211	Q9Y2W7
VAEEAADRHPERRMR	CCDC124	156	Q96CT7
PFVEEAERLRVQHMQ	SOX17	116	Q9H6I2
RPFIDEAKRLRAVHM	SOX3	186	P41225
EAMERRVQAVREIHP	POLR1A	1496	O95602
HTFRRQNVREEPREM	PLD1	146	Q13393
SMLNKAREEHRIPER	ITIH3	371	Q06033
DRLHLFPEENTRMRK	FSD2	31	A1L4K1
HLIPFMEKEREETRV	MTR	746	Q99707
FVKRQIEDMDDHRPF	RHBDF1	391	Q96CC6
EREHRRPVKENFLHM	TGM4	461	P49221
NEVERMLERHERFKP	USP53	191	Q70EK8
KDERRKILQAFPDMH	SOX13	436	Q9UN79
EEVQMRQHDTRPETR	SHANK3	526	Q9BYB0
MEERKVNLHLPRFEV	SERPINB13	276	Q9UIV8
RFRHMEIDKKRSEIP	ZC3H11A	51	O75152
RPFIEEAERLRMQHK	SOX10	151	P56693
HRIKLNDRMTFPEEL	USP47	401	Q96K76
DFRKAVMVLPDENHR	MYCBPAP	726	Q8TBZ2
EHTKRFEDMIAPFRL	SLC12A3	906	P55017
IHKFALMNRRFPEED	SNX10	146	Q9Y5X0
RFRHMEIDKKRSEIP	ZC3H11B	51	A0A1B0GTU1
KRKHDDDRRFMCPVE	ZXDA	471	P98168
MHRTQRVDDPQDVFK	SUN1	326	O94901
DMRDERKERRGPEAH	TCHHL1	386	Q5QJ38
EGIQPKRRRRHMENE	TRIM66	1186	O15016
MEPRYHVRREDLDKL	POTEH	166	Q6S545
FAMVTHVKQEPRERE	TRRAP	2536	Q9Y4A5
EMQRQRFRLEFEKHR	TRIM58	176	Q8NG06
REVVDSRPRHRMFEQ	ZMAT1	256	Q5H9K5