Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR2W3 GPR6 OR6V1 GPR61 TRHR AVPR1A OR4D9 MC1R OR4K3 OR4K15 AR OR13J1 OR10D4P

5.32e-068846613GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

TGFBR1 OR2W3 GPR6 OR6V1 GPR61 PTPRF TRHR AVPR1A OR4D9 MC1R OR4K3 OR4K15 AR OR13J1 FCMR OR10D4P

6.09e-0613536616GO:0004888
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR2W3 GPR6 OR6V1 GTF2H2 GPR61 TRHR AVPR1A OR4D9 MC1R DGKQ OR4K3 OR4K15 AR OR13J1 OR10D4P

3.21e-0513956715GO:0007186
GeneOntologyBiologicalProcesssensory perception

OR2W3 OR6V1 PIEZO2 LOXHD1 MYO7A MYO7B OR4D9 CNTN5 MC1R OR4K3 OR4K15 OR13J1 OR10D4P

3.47e-0510726713GO:0007600
DomainsnRNP-assoc_SmB/SmN

SNRPB SNRPN

1.23e-052662IPR017131
DomainGPCR_Rhodpsn_7TM

OR2W3 GPR6 OR6V1 GPR61 TRHR AVPR1A OR4D9 MC1R OR4K15 OR13J1

1.13e-046706610IPR017452
Domain7tm_1

OR2W3 GPR6 OR6V1 GPR61 TRHR AVPR1A OR4D9 MC1R OR4K15 OR13J1

1.24e-046776610PF00001
DomainG_PROTEIN_RECEP_F1_1

OR2W3 GPR6 OR6V1 GPR61 TRHR AVPR1A OR4D9 MC1R OR4K15 OR13J1

1.36e-046856610PS00237
DomainG_PROTEIN_RECEP_F1_2

OR2W3 GPR6 OR6V1 GPR61 TRHR AVPR1A OR4D9 MC1R OR4K15 OR13J1

1.46e-046916610PS50262
DomainGPCR_Rhodpsn

OR2W3 GPR6 OR6V1 GPR61 TRHR AVPR1A OR4D9 MC1R OR4K15 OR13J1

1.48e-046926610IPR000276
DomainMYTH4

MYO7A MYO7B

4.36e-049662PS51016
DomainMyTH4_dom

MYO7A MYO7B

4.36e-049662IPR000857
DomainMyTH4

MYO7A MYO7B

4.36e-049662PF00784
DomainMyTH4

MYO7A MYO7B

4.36e-049662SM00139
DomainAMP-bd_C

ACSF2 ACSS3

1.62e-0317662IPR025110
DomainAMP-binding_C

ACSF2 ACSS3

1.62e-0317662PF13193
DomainLH2

LOXHD1 PKD1L1

1.81e-0318662SM00308
DomainSm

SNRPB SNRPN

2.02e-0319662SM00651
DomainLSM

SNRPB SNRPN

2.02e-0319662PF01423
DomainLSM_dom_euk/arc

SNRPB SNRPN

2.02e-0319662IPR001163
DomainPLAT

LOXHD1 PKD1L1

2.47e-0321662PS50095
Domain-

LOXHD1 PKD1L1

2.47e-03216622.60.60.20
DomainPLAT

LOXHD1 PKD1L1

2.47e-0321662PF01477
DomainPLAT/LH2_dom

LOXHD1 PKD1L1

2.47e-0321662IPR001024
DomainLSM_dom

SNRPB SNRPN

2.71e-0322662IPR010920
DomainAMP-binding_CS

ACSF2 ACSS3

3.78e-0326662IPR020845
DomainAMP_BINDING

ACSF2 ACSS3

4.38e-0328662PS00455
DomainAMP-binding

ACSF2 ACSS3

5.02e-0330662PF00501
DomainAMP-dep_Synth/Lig

ACSF2 ACSS3

5.02e-0330662IPR000873
DomainAlkaline_phosphatase_core

ENPP6 ARSI

5.35e-0331662IPR017850
DomainAlkaline_Pase-like_a/b/a

ENPP6 ARSI

5.35e-0331662IPR017849
Domain-

ENPP6 ARSI

5.35e-03316623.40.720.10
DomainMyosin_head_motor_dom

MYO7A MYO7B

7.97e-0338662IPR001609
DomainMYOSIN_MOTOR

MYO7A MYO7B

7.97e-0338662PS51456
DomainMyosin_head

MYO7A MYO7B

7.97e-0338662PF00063
DomainMYSc

MYO7A MYO7B

7.97e-0338662SM00242
Pubmed

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.

LOXHD1 MYO7A MC1R SLC12A7

1.71e-064468427534441
Pubmed

The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein.

SNRPB SNRPN

3.77e-0626828510173
Pubmed

Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells.

ABCC4 AR

3.77e-06268217003774
Pubmed

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine.

TGFBR1 HUWE1

3.77e-06268228931816
Pubmed

Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci.

SNRPB SNRPN

3.77e-06268210556313
Pubmed

A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'.

SNRPB SNRPN

1.13e-0536822522186
Pubmed

Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs.

SNRPB SNRPN

1.13e-0536827744014
Pubmed

Associations between neurochemical receptor genes, 2D:4D, impulsivity and relationship quality.

AVPR1A AR

1.13e-05368230518641
Pubmed

The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.

SNRPB SNRPN

3.75e-05568218362360
Pubmed

Tails of unconventional myosins.

MYO7A MYO7B

7.86e-05768211212352
Pubmed

A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing.

SNRPB SNRPN

7.86e-05768212456665
Pubmed

The human olfactory receptor gene family.

OR2W3 OR6V1 OR4D9 OR4K3 OR4K15 OR13J1 OR10D4P

9.05e-0554168714983052
Pubmed

Multiple protein: protein interactions between the snRNP common core proteins.

SNRPB SNRPN

1.05e-0486829417867
Pubmed

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

RORC AR

1.05e-04868222170608
Pubmed

Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.

ACSF2 ACSS3

1.68e-041068217762044
Pubmed

Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.

SNRPB SNRPN

1.68e-041068215105431
Pubmed

A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.

LOXHD1 MYO7A

1.68e-041068217329413
Pubmed

Association analysis of 15 polymorphisms within 10 candidate genes for antisocial behavioural traits.

AVPR1A AR

1.68e-041068217728669
Pubmed

The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process.

GTF2H2 AR

2.05e-041168221157430
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

TGFBR1 INTS5 PTPRF TOR1A HUWE1 ACSF2 SLC12A7 HIBADH MTCH1

2.17e-04106168933845483
Pubmed

The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.

SNRPB SNRPN

2.45e-041268211713266
Pubmed

A functional interaction between the survival motor neuron complex and RNA polymerase II.

SNRPB SNRPN

2.90e-041368211149922
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

CERS5 GTF2H2 RBL2 RORC TEAD3 RFX4 AR FCMR

3.08e-0487768820211142
Pubmed

Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.

SNRPB SNRPN

3.38e-041468210725331
Pubmed

Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

MYO7A MYO7B

3.38e-04146828022818
Pubmed

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.

FREM2 MYO7A MC1R

3.87e-047268325917818
Pubmed

Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.

MYO7A MC1R

3.89e-041568218715234
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR2W3 OR4K15 OR10D4P

4.20e-047468315081110
Pubmed

Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.

CNTN5 RFX4

4.44e-041668217903297
Pubmed

The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.

MYO7A RBL2

5.65e-041868215843406
Pubmed

Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.

LOXHD1 MYO7A

5.65e-041868233087486
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FREM2 LOXHD1 MYO7A FAM120C HIC2 HUWE1 CPT1B

5.85e-0473668729676528
Pubmed

Identification of genes concordantly expressed with Atoh1 during inner ear development.

MYO7A RORC

6.30e-041968221519551
Pubmed

Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.

MYO7A MYO7B

6.30e-041968234124068
Pubmed

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.

SNRPB SNRPN

8.48e-042268218984161
Pubmed

Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains.

AVPR1A MC1R

1.01e-032468215561968
Pubmed

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.

RNF167 PTPRF

1.19e-032668236178190
Pubmed

The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.

AP1G1 HUWE1

1.91e-033368226296893
Pubmed

Genome-wide association scan of dental caries in the permanent dentition.

PIEZO2 RBMS3

1.91e-033368223259602
InteractionFKBP4 interactions

NPHP1 LOXHD1 AP1G1 FAM120C GLE1 HIBADH MTCH1 AR

2.86e-06285638int:FKBP4
GeneFamilyA-kinase anchoring proteins|Myosins, class VII|Deafness associated genes|FERM domain containing

MYO7A MYO7B

6.33e-0624621102
GeneFamilyAcyl-CoA synthetase family

ACSF2 ACSS3

1.98e-032646240
GeneFamilyOlfactory receptors, family 4

OR4D9 OR4K3 OR4K15

4.31e-03129463151
GeneFamilyNuclear hormone receptors

RORC AR

6.90e-034946271
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO7A MYO7B

7.18e-03504621293
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PTPRF CNTN5 MDGA2

7.95e-03161463593
GeneFamilyImmunoglobulin like domain containing

CNTN5 MDGA2 FCMR

1.30e-02193463594
GeneFamilyG protein-coupled receptors, Class A orphans

GPR6 GPR61

1.68e-0278462262
GeneFamilySolute carriers

SLC6A7 SLC12A7 MTCH1 SLC25A45

1.78e-02395464752
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 PIEZO2 LOXHD1 MYO7B MDGA2

8.52e-061846752cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 PIEZO2 LOXHD1 MYO7B MDGA2

8.52e-06184675ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 PIEZO2 LOXHD1 MYO7B MDGA2

8.52e-061846752b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

RBMS3 RBL2 CPT1B SNRPN SLC25A45

1.27e-05200675a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
Diseasesleep quality

ENPP6 TRHR RBMS3 RFX4

1.06e-04118614EFO_0005272
Diseasetauopathy (implicated_via_orthology)

SNRPB SNRPN

1.87e-0410612DOID:680 (implicated_via_orthology)
DiseaseYu-Zhi constitution type

FREM2 PIEZO2

4.34e-0415612EFO_0007638
Diseasedental caries

MTMR4 PIEZO2 RBMS3 ACSS3

6.15e-04187614EFO_0003819
Diseaseperiodontal measurement

RBMS3 SNRPN

1.13e-0324612EFO_0007780
Diseasedigestive system infectious disorder

RBMS3 CNTN5

1.32e-0326612MONDO_0043424
Diseaseblood viscosity

PTPRF MDGA2

1.88e-0331612EFO_0004301

Protein segments in the cluster

PeptideGeneStartEntry
GNVARRKYAAMVTCM

ARSI

256

Q5FYB1
LVEVAMGCRHVQRTM

DGKQ

446

P52824
CVRMYELVHRMKGTE

GLE1

131

Q53GS7
MAVYVGMLRLGRLCA

ACSF2

1

Q96CM8
ICLMIGMAHVLVVYR

ANO9

341

A1A5B4
SYINNMVRVGTLIMC

CERS5

231

Q8N5B7
MIRNILLMHAGRYGC

CNTN5

636

O94779
RIMILHQLLCQYMTA

RBMS3

356

Q6XE24
FIMMYRTHCQRILDT

RFX4

201

Q33E94
QGHRVLIYSQMTRMI

INO80

1116

Q9ULG1
LTMEYRLSQACMRGH

HIBCH

326

Q6NVY1
VLMAVLYVHMLARAC

MC1R

201

Q01726
RHLDQLLMCAIYVMA

RBL2

886

Q08999
RCRNVAKLLYMHMLG

AP1G1

46

O43747
FCMRVMVGVIILYDH

CYRIA

251

Q9H0Q0
TVIMNHRVCFMLATG

OR10D4P

131

Q8NGN7
VVYCSMFRVARVAAM

GPR61

226

Q9BZJ8
MVFGIMLHLYVRICQ

GPR6

236

P46095
SVRCYTRQGSAQVMM

FREM2

2161

Q5SZK8
VRRIMGMARYHVTVC

LOXHD1

546

Q8IVV2
HYMVIMNPRLCRGLV

OR2W3

131

Q7Z3T1
HYLTIMSRRMCVGLV

OR4K3

131

Q96R72
ICKPLHYMTVMSRRV

OR4K15

126

Q8NH41
HYMTVMSRRVCVVLV

OR4K15

131

Q8NH41
HMIYMRALQIVYGIR

NUF2

46

Q9BZD4
RRILIGMYNCAHEML

NCKAP1L

151

P55160
MYSQCVRMRHLSQEF

AR

781

P10275
RYHVLMSHRLCVLLM

OR13J1

131

Q8NGT2
AYIMMFVHTCRVGQS

HUWE1

901

Q7Z6Z7
YVHLVCQMRMTGAIR

HUWE1

4206

Q7Z6Z7
RIVNVSREMSGMYRC

MDGA2

501

Q7Z553
CEVVFMGMANIHAIR

MTMR4

336

Q9NYA4
HYMTIMSRGRCTGLI

OR4D9

131

Q8NGE8
HPLRYGTLMSRAMCV

OR6V1

126

Q8N148
FYHVQCAGMRLRVAM

ABCC4

156

O15439
LRVAMCHMIYRKALR

ABCC4

166

O15439
CHMIYRKALRLSNMA

ABCC4

171

O15439
THLLLMCCVLRYMVQ

FAM120C

761

Q9NX05
TRRHLCMVMEYVEGG

MAST3

436

O60307
YTLMTGRHCEVHQMI

ENPP6

76

Q6UWR7
AMLHNMRVYGTCTLV

SLC12A7

246

Q9Y666
IHLCVQLYRMMDKGV

PKD1L1

2536

Q8TDX9
AARLGNIIHAMIMYR

CPT1B

271

Q92523
HVSFCYLIVLMRNRM

NPHP1

266

O15259
IYGHVTCMRSQRNYM

PTPRF

1576

P10586
CGMRFTRQYRLTEHM

HIC2

566

Q96JB3
HVISMRCMVQFVGRE

MTCH1

216

Q9NZJ7
GQVRLGMMRHLYVVV

GTF2H2C;

51

Q6P1K8
YHQVRCMMAILFLIG

PUS3

276

Q9BZE2
SSKMLQHIDYRMRCI

SNRPN

6

P63162
MRTKHMRTPTNCYLV

TRHR

51

P34981
MSDTRVHMSLRRYCQ

NTN5

351

Q8WTR8
LAMGAVMIARCIQHR

RNF167

186

Q9H6Y7
SSKMLQHIDYRMRCI

SNRPB

6

P14678
MGCRATRTLMDIYVQ

INTS5

181

Q6P9B9
VYGIQRFCRDIHMML

SLC6A7

476

Q99884
LMLMVYICHNRTVIH

TGFBR1

141

P36897
LLGSLAHQIYRMMCA

HIBADH

301

P31937
AMYTMLACARIGAIH

ACSS3

181

Q9H6R3
HLKMCIRVEMQSRGY

TOR1A

276

O14656
GAMEVVLVRMCRAYN

RORC

356

P51449
RRVYQGMLDCMVSSI

SLC25A45

236

Q8N413
GQVRLGMMRHLYVVV

GTF2H2

51

Q13888
RIHRSPMCEYMINFI

TEAD3

361

Q99594
VMHLGIRSARCVLGM

THEMIS2

136

Q5TEJ8
EMHVRIYLCREMAGS

FCMR

41

O60667
RSEMVCYFVIILNHM

PIEZO2

1921

Q9H5I5
RFRMKCHLCVNYIEM

YJU2B

86

P13994
MLVVMTADRYIAVCH

AVPR1A

141

P37288
IDMICRAHQLVMEGY

PPP4C

231

P60510
VGMPVMHRNVRYNCR

NADSYN1

86

Q6IA69
LCVRQLRYSGMMETI

MYO7A

651

Q13402
CLRQLRYSGMMETVH

MYO7B

671

Q6PIF6