Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	fibrillar center	TXNRD1 FAM111A MAP3K14 KIT STN1	3.51e-05	156	50	5	GO:0001650
GeneOntologyCellularComponent	heteromeric SMAD protein complex	SMAD1 SMAD5	1.56e-04	8	50	2	GO:0071144
GeneOntologyCellularComponent	SMAD protein complex	SMAD1 SMAD5	2.49e-04	10	50	2	GO:0071141
Domain	Dwarfin	SMAD1 SMAD5	1.95e-04	8	50	2	IPR013790
Domain	DWB	SMAD1 SMAD5	1.95e-04	8	50	2	SM00524
Domain	MH2	SMAD1 SMAD5	1.95e-04	8	50	2	PS51076
Domain	MH1	SMAD1 SMAD5	1.95e-04	8	50	2	PS51075
Domain	-	SMAD1 SMAD5	1.95e-04	8	50	2	3.90.520.10
Domain	MAD_homology_MH1	SMAD1 SMAD5	1.95e-04	8	50	2	IPR013019
Domain	MH2	SMAD1 SMAD5	1.95e-04	8	50	2	PF03166
Domain	SMAD_dom_Dwarfin-type	SMAD1 SMAD5	1.95e-04	8	50	2	IPR001132
Domain	MAD_homology1_Dwarfin-type	SMAD1 SMAD5	4.56e-04	12	50	2	IPR003619
Domain	DWA	SMAD1 SMAD5	4.56e-04	12	50	2	SM00523
Domain	MH1	SMAD1 SMAD5	4.56e-04	12	50	2	PF03165
Domain	SMAD_dom-like	SMAD1 SMAD5	8.23e-04	16	50	2	IPR017855
Domain	-	SMAD1 SMAD5	8.23e-04	16	50	2	2.60.200.10
Domain	-	LAMA2 CLSTN2 LRBA	2.10e-03	95	50	3	2.60.120.200
Pathway	REACTOME_REGULATION_OF_TP53_DEGRADATION	PHF20 RICTOR ATM	1.03e-04	36	36	3	MM15339
Pathway	REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION	PHF20 RICTOR ATM	1.12e-04	37	36	3	M27641
Pathway	WP_NEOVASCULARIZATION_PROCESSES	KIT SMAD1 SMAD5	1.12e-04	37	36	3	M39506
Pathway	KEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY	SMAD1 SMAD5	1.32e-04	7	36	2	M47845
Pathway	KEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY	SMAD1 SMAD5	1.76e-04	8	36	2	M47847
Pathway	KEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY	SMAD1 SMAD5	2.26e-04	9	36	2	M47844
Pathway	KEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY	SMAD1 SMAD5	2.26e-04	9	36	2	M47822
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	MAP3K14 RICTOR MAPK10 MAP3K6	3.43e-04	132	36	4	M39338
Pathway	PID_ALK2_PATHWAY	SMAD1 SMAD5	3.44e-04	11	36	2	M203
Pathway	KEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY	SMAD1 SMAD5	3.44e-04	11	36	2	M47848
Pathway	WP_MARKERS_OF_KIDNEY_CELL_LINEAGE	KIT SMAD1 SMAD5	4.51e-04	59	36	3	M46460
Pathway	WP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION	SMAD1 SMAD5	4.86e-04	13	36	2	M39378
Pubmed	mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics.	VANGL2 RICTOR SMAD1 SMAD5	1.84e-07	34	51	4	32866472
Pubmed	Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.	VANGL2 SMAD1 SMAD5	6.47e-07	12	51	3	20962035
Pubmed	The expression and crucial roles of BMP signaling in development of smooth muscle progenitor cells in the mouse embryonic gut.	KIT SMAD1 SMAD5	8.41e-07	13	51	3	19272526
Pubmed	Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.	MAP3K14 SMAD1 SMAD5	8.41e-07	13	51	3	25376721
Pubmed	Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.	KIT SMAD1 SMAD5	1.07e-06	14	51	3	26952187
Pubmed	mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathway.	RICTOR SMAD1 SMAD5	1.99e-06	17	51	3	34052210
Pubmed	BMP signaling dynamics in embryonic orofacial tissue.	SMAD1 SMAD5	2.11e-06	2	51	2	18446813
Pubmed	Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization.	SMAD1 SMAD5	2.11e-06	2	51	2	21723296
Pubmed	Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro.	SMAD1 SMAD5	2.11e-06	2	51	2	24297369
Pubmed	BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.	SMAD1 SMAD5	2.11e-06	2	51	2	26711875
Pubmed	The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling.	SMAD1 SMAD5	2.11e-06	2	51	2	11451566
Pubmed	Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum.	ACP6 KIT	2.11e-06	2	51	2	12010880
Pubmed	BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development.	SMAD1 SMAD5	2.11e-06	2	51	2	32210087
Pubmed	BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow.	SMAD1 SMAD5	2.11e-06	2	51	2	23387849
Pubmed	Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.	SMAD1 SMAD5	2.11e-06	2	51	2	8799132
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	VANGL2 ESYT2 SEC23IP RICTOR LRBA USP6NL FAM83B	2.65e-06	421	51	7	36976175
Pubmed	Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.	LAMA2 SMAD1 SMAD5	2.83e-06	19	51	3	27234308
Pubmed	Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.	SMAD1 SMAD5	6.32e-06	3	51	2	10652350
Pubmed	Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.	SMAD1 SMAD5	6.32e-06	3	51	2	30953749
Pubmed	Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.	SMAD1 SMAD5	6.32e-06	3	51	2	32720893
Pubmed	TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.	SMAD1 SMAD5	6.32e-06	3	51	2	29376829
Pubmed	Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.	SMAD1 SMAD5	6.32e-06	3	51	2	21381028
Pubmed	Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.	SMAD1 SMAD5	6.32e-06	3	51	2	20371744
Pubmed	BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells.	SMAD1 SMAD5	6.32e-06	3	51	2	15246821
Pubmed	Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling.	ATM SMAD1	6.32e-06	3	51	2	22510377
Pubmed	BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors.	SMAD1 SMAD5	6.32e-06	3	51	2	22964636
Pubmed	TGF-β1, but not bone morphogenetic proteins, activates Smad1/5 pathway in primary human macrophages and induces expression of proatherogenic genes.	SMAD1 SMAD5	6.32e-06	3	51	2	25505291
Pubmed	Fluoride promotes viability and differentiation of osteoblast-like Saos-2 cells via BMP/Smads signaling pathway.	SMAD1 SMAD5	6.32e-06	3	51	2	23918166
Pubmed	Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.	SMAD1 SMAD5	6.32e-06	3	51	2	24023003
Pubmed	Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.	SMAD1 SMAD5	6.32e-06	3	51	2	27848974
Pubmed	Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.	SMAD1 SMAD5	6.32e-06	3	51	2	20522807
Pubmed	Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.	SMAD1 SMAD5	6.32e-06	3	51	2	31127639
Pubmed	Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.	SMAD1 SMAD5	6.32e-06	3	51	2	22897816
Pubmed	TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.	SMAD1 SMAD5	6.32e-06	3	51	2	19096363
Pubmed	BMP9 promotes cutaneous wound healing by activating Smad1/5 signaling pathways and cytoskeleton remodeling.	SMAD1 SMAD5	6.32e-06	3	51	2	33463047
Pubmed	Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.	SMAD1 SMAD5	6.32e-06	3	51	2	21945631
Pubmed	Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins.	SMAD1 SMAD5	6.32e-06	3	51	2	14711801
Pubmed	Molecular Interaction Between Smurfl WW2 Domain and PPXY Motifs of Smadl, Smad5, and Smad6-Modeling and Analysis.	SMAD1 SMAD5	6.32e-06	3	51	2	22670624
Pubmed	Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.	SMAD1 SMAD5	6.32e-06	3	51	2	30367512
Pubmed	Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line.	SMAD1 SMAD5	6.32e-06	3	51	2	25165122
Pubmed	Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage.	SMAD1 SMAD5	6.32e-06	3	51	2	12649288
Pubmed	Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation.	SMAD1 SMAD5	6.32e-06	3	51	2	25880873
Pubmed	Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5.	SMAD1 SMAD5	6.32e-06	3	51	2	16247476
Pubmed	Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.	VANGL2 SMAD1 SMAD5	7.54e-06	26	51	3	23974041
Pubmed	Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps.	CLSTN2 SMAD1 SMAD5	9.48e-06	28	51	3	17698011
Pubmed	Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins.	VANGL2 SMAD1 SMAD5	9.48e-06	28	51	3	19762422
Pubmed	Msx1 is essential for proper rostral tip formation of the mouse mandible.	SMAD1 SMAD5	1.26e-05	4	51	2	36566565
Pubmed	Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus.	SMAD1 SMAD5	1.26e-05	4	51	2	19247629
Pubmed	A crucial role of a high mobility group protein HMGA2 in cardiogenesis.	SMAD1 SMAD5	1.26e-05	4	51	2	18425117
Pubmed	Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.	SMAD1 SMAD5	1.26e-05	4	51	2	23993924
Pubmed	Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6--modeling and analysis.	SMAD1 SMAD5	1.26e-05	4	51	2	17676934
Pubmed	SMAD Signaling Is Required for Structural Integrity of the Female Reproductive Tract and Uterine Function During Early Pregnancy in Mice.	SMAD1 SMAD5	1.26e-05	4	51	2	27335065
Pubmed	The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.	SMAD1 SMAD5	1.26e-05	4	51	2	15557274
Pubmed	The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo.	SMAD1 SMAD5	1.26e-05	4	51	2	23203803
Pubmed	Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.	SMAD1 SMAD5	1.26e-05	4	51	2	15107829
Pubmed	Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice.	SMAD1 SMAD5	1.26e-05	4	51	2	17967875
Pubmed	Silencing of miR-330-5p stimulates osteogenesis in bone marrow mesenchymal stem cells and inhibits bone loss in osteoporosis by activating Bgn-mediated BMP/Smad pathway.	SMAD1 SMAD5	1.26e-05	4	51	2	32374006
Pubmed	Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response.	SMAD1 SMAD5	1.26e-05	4	51	2	26391659
Pubmed	Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin.	SMAD1 SMAD5	1.26e-05	4	51	2	22452883
Pubmed	TGFβ signaling promotes juvenile granulosa cell tumorigenesis by suppressing apoptosis.	SMAD1 SMAD5	1.26e-05	4	51	2	25243859
Pubmed	Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.	SMAD1 SMAD5	1.26e-05	4	51	2	21239498
Pubmed	KMUP-1 Promotes Osteoblast Differentiation Through cAMP and cGMP Pathways and Signaling of BMP-2/Smad1/5/8 and Wnt/β-Catenin.	SMAD1 SMAD5	1.26e-05	4	51	2	25536014
Pubmed	Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.	SMAD1 SMAD5	1.26e-05	4	51	2	28401685
Pubmed	SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors.	SMAD1 SMAD5	1.26e-05	4	51	2	30188920
Pubmed	Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.	SMAD1 SMAD5	1.26e-05	4	51	2	18684712
Pubmed	Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells.	SMAD1 SMAD5	1.26e-05	4	51	2	19244313
Pubmed	Signal transduction of bone morphogenetic protein receptors.	SMAD1 SMAD5	1.26e-05	4	51	2	14687659
Pubmed	Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells.	SMAD1 SMAD5	1.26e-05	4	51	2	17359969
Pubmed	Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.	SMAD1 SMAD5	1.26e-05	4	51	2	28438754
Pubmed	Interaction of TGFβ and BMP signaling pathways during chondrogenesis.	SMAD1 SMAD5	1.26e-05	4	51	2	21297990
Pubmed	Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.	CNTN4 KIT	1.26e-05	4	51	2	23904439
Pubmed	Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK.	SMAD1 SMAD5	1.26e-05	4	51	2	24021264
Pubmed	Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.	SMAD1 SMAD5	1.26e-05	4	51	2	25755279
Pubmed	The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress.	SMAD1 SMAD5	1.26e-05	4	51	2	27483343
Pubmed	Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.	SMAD1 SMAD5	1.26e-05	4	51	2	34719843
Pubmed	Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1.	SMAD1 SMAD5	1.26e-05	4	51	2	28642261
Pubmed	Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.	SMAD1 SMAD5	1.26e-05	4	51	2	38246328
Pubmed	mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development.	RICTOR SMAD1 SMAD5	1.57e-05	33	51	3	29975682
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	VANGL2 ESYT2 EHBP1L1 RICTOR LRBA USP6NL FAM83B	1.88e-05	569	51	7	30639242
Pubmed	Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.	SMAD1 SMAD5	2.10e-05	5	51	2	27188281
Pubmed	Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.	SMAD1 SMAD5	2.10e-05	5	51	2	38703029
Pubmed	SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.	SMAD1 SMAD5	2.10e-05	5	51	2	25870111
Pubmed	Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.	SMAD1 SMAD5	2.10e-05	5	51	2	11121043
Pubmed	Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway.	SMAD1 SMAD5	2.10e-05	5	51	2	27025722
Pubmed	Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo.	SMAD1 SMAD5	2.10e-05	5	51	2	20651281
Pubmed	Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.	SMAD1 SMAD5	2.10e-05	5	51	2	18566469
Pubmed	The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.	SMAD1 SMAD5	2.10e-05	5	51	2	15647271
Pubmed	Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse.	SMAD1 SMAD5	2.10e-05	5	51	2	38300806
Pubmed	The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.	SMAD1 SMAD5	2.10e-05	5	51	2	29934521
Pubmed	Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors.	SMAD1 SMAD5	2.10e-05	5	51	2	19819941
Pubmed	Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells.	SMAD1 SMAD5	2.10e-05	5	51	2	16436528
Pubmed	A crucial role for bone morphogenetic protein-Smad1 signalling in the DNA damage response.	ATM SMAD1	2.10e-05	5	51	2	22588298
Pubmed	Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.	SMAD1 SMAD5	2.10e-05	5	51	2	25141865
Pubmed	The TGFβ pathway is a key player for the endothelial-to-hematopoietic transition in the embryonic aorta.	SMAD1 SMAD5	2.10e-05	5	51	2	29253505
Pubmed	BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.	SMAD1 SMAD5	2.10e-05	5	51	2	26771354
Pubmed	Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.	SMAD1 SMAD5	2.10e-05	5	51	2	27612439
Pubmed	Histone methyltransferase Setdb1 is indispensable for Meckel's cartilage development.	SMAD1 SMAD5	2.10e-05	5	51	2	27890611
Pubmed	Effect of stimulated erythropoiesis on liver SMAD signaling pathway in iron-overloaded and iron-deficient mice.	SMAD1 SMAD5	2.10e-05	5	51	2	30958854
Pubmed	Impaired SMAD1/5 Mechanotransduction and Cx37 (Connexin37) Expression Enable Pathological Vessel Enlargement and Shunting.	SMAD1 SMAD5	2.10e-05	5	51	2	32078368
Pubmed	The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.	SMAD1 SMAD5	2.10e-05	5	51	2	21246655
GeneFamily	SMAD family	SMAD1 SMAD5	1.01e-04	8	35	2	750
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K14 MAP3K6	9.78e-04	24	35	2	654
Coexpression	MATZUK_EMBRYONIC_GERM_CELL	KIT SMAD1 SMAD5	6.19e-06	19	50	3	M1821
ToppCell	Differ-Basal\|World / shred by cell class for mouse tongue	ALDH3A1 FUT2 KIT MAP3K6 USP6NL	2.83e-06	194	51	5	851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	TXNRD1 CNTN4 LAMA2 CLSTN2 MAPK10	2.98e-06	196	51	5	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EHBP1L1 LAMA2 MCF2 HEPH	3.72e-05	164	51	4	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-6\|TCGA-Liver / Sample_Type by Project: Shred V9	CNTN4 LAMA2 CLSTN2 HEPH	4.18e-05	169	51	4	e992530776cab922d0360b275fb9cb8bd0017b06
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1D LAMA2 MCF2 HEPH	4.28e-05	170	51	4	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1D LAMA2 MCF2 HEPH	4.28e-05	170	51	4	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	severe_influenza-Plasmablast\|severe_influenza / disease group, cell group and cell class (v2)	MYO1D IGHG1 CAMSAP3 CCDC148	4.69e-05	174	51	4	8c6c4d794373e774ecb3382cb7163b4246b98780
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH3A1 KIT MAP3K6 USP6NL	4.79e-05	175	51	4	31f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CNTN4 MAPK10 FAM83B CCDC148	5.58e-05	182	51	4	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CNTN4 LAMA2 CLSTN2 KIT	5.82e-05	184	51	4	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	Healthy-multiplets\|Healthy / disease group, cell group and cell class	MYO1D IGHG1 CLSTN2 KIT	6.07e-05	186	51	4	2ec999b97e95afb898f8083042b0f188d3d234bc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ESYT2 MYO1D FAM83B CCDC148	6.20e-05	187	51	4	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ESYT2 MYO1D FAM83B CCDC148	6.20e-05	187	51	4	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ESYT2 MYO1D FAM83B CCDC148	6.20e-05	187	51	4	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ESYT2 MYO1D FAM83B CCDC148	6.20e-05	187	51	4	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	COVID-19-Epithelial-Ionocytes\|COVID-19 / Condition, Lineage and Cell class	VANGL2 FUT2 KIT FAM83B	6.33e-05	188	51	4	a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KLHL2 EHBP1L1 DRAM1 IGHG1	6.59e-05	190	51	4	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	TXNRD1 LAMA2 CLSTN2 MAPK10	6.87e-05	192	51	4	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	LA\|World / Chamber and Cluster_Paper	CNTN4 MYO1D CLSTN2 MAPK10	7.01e-05	193	51	4	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	TXNRD1 LAMA2 CLSTN2 MAPK10	7.29e-05	195	51	4	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm\|1m / Sample Type, Dataset, Time_group, and Cell type.	EHBP1L1 DRAM1 BEND3 FUT2	8.04e-05	200	51	4	c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
Drug	Xamoterol hemifumarate [73210-73-8]; Up 200; 5uM; HL60; HT_HG-U133A	KCNE2 PHF20 MCF2 ABHD8 MAP3K6 HEPH	4.37e-06	196	50	6	3064_UP
Disease	marginal zone B- and B1-cell-specific protein measurement	DNAH12 IGHG1	1.68e-05	4	50	2	EFO_0802730
Disease	Small Lymphocytic Lymphoma	IGHG1 ATM	1.26e-04	10	50	2	C0855095
Disease	B-CELL MALIGNANCY, LOW-GRADE	IGHG1 ATM	1.26e-04	10	50	2	C1868683
Disease	juvenile polyposis syndrome (implicated_via_orthology)	SMAD1 SMAD5	2.17e-04	13	50	2	DOID:0050787 (implicated_via_orthology)
Disease	Dyskeratosis Congenita	USB1 STN1	3.33e-04	16	50	2	C0265965
Disease	Pseudoaphakia	ATM ALDH3A1	7.58e-04	24	50	2	C0524524
Disease	Lens Opacities	ATM ALDH3A1	7.58e-04	24	50	2	C1510497
Disease	melanoma	ATM MAGEC1 KIT USP6NL	8.28e-04	248	50	4	C0025202
Disease	lung small cell carcinoma (is_implicated_in)	RICTOR ATM	1.03e-03	28	50	2	DOID:5409 (is_implicated_in)
Disease	triacylglycerol 54:7 measurement	CNTN4 MAGEC1	1.03e-03	28	50	2	EFO_0010425
Disease	refractive error, self reported educational attainment	DIS3L LAMA2	1.52e-03	34	50	2	EFO_0004784, MONDO_0004892

Protein segments in the cluster

Peptide	Gene	Start	Entry
VAVWILEKYYHDFPV	VANGL2	271	Q9ULK5
PKWNEVYEALVYEHP	ESYT2	436	A0FGR8
EEDHWIYQAILDQYP	CCDC148	261	Q8NFR7
DPDYWEKLLRHHYEQ	CHD5	1316	Q8TDI0
HEWTYEEQFKQLYEL	ARID3C	96	A6NKF2
DLHKNEWNAYYEEVV	ALDH3A1	51	P30838
YEVKYWRHEDKEENA	CNTN4	836	Q8IWV2
YVEELHKWRCPDYYE	ACTR5	256	Q9H9F9
DKEWHYYVINVEFPV	CLSTN2	451	Q9H4D0
LWEPFYTDQYAQEHV	CAMSAP3	56	Q9P1Y5
YWPEGDEVYHAELTV	ABHD8	346	Q96I13
AVYPVEKMEEVWHYE	BEND3	786	Q5T5X7
LEWNPREKDYVYHVV	DRAM1	186	Q8N682
NPVDWKEQYIHENYS	PLOD3	536	O60568
KVWVQEHYLEYREVP	MAGEC1	1046	O60732
HPYINVWYDPAEVEA	MAPK10	356	P53779
EYEAFPKPEHQQWIY	KIT	336	P10721
EPHYKEWYRVAIDIL	FAM83B	21	Q5T0W9
EQAYHWYRKAFDVEP	MAP3K6	376	O95382
HIYEWREIYDSKEPH	DNAH12	2416	Q6ZR08
RDPHVDQYEAKEWTF	EHBP1L1	86	Q8N3D4
ERYESWEDDQVPKFH	LRBA	2286	P50851
VEYKPWQYHAVTDTE	LAMA2	161	P24043
NDPYHQYIVEDWQEK	KCNE2	81	Q9Y6J6
WHREYNSKYVDLIEE	RICTOR	831	Q6R327
QEAEYHYLEAQEWKA	IFT172	1046	Q9UG01
VQAEYWHDPIKEDVY	PPT1	181	P50897
YENKDWCPELEELHY	ATM	2086	Q13315
DWMEEEYRHIPGEYV	FUT2	131	Q10981
THYVIPDWKVVQDYL	DIS3L	56	Q8TF46
FVEPWFEIHNEELDY	FAM111A	426	Q96PZ2
FEIWYGEKEEVYIVQ	MCF2	776	P10911
HEDPEVKFNWYVDGV	IGHG1	151	P01857
LKPVDYEYREEVHWA	MAP3K14	386	Q99558
KNWYPAHIEDIDYEE	PHF20	26	Q9BVI0
EIHATTYYKVDDPVW	STN1	146	Q9H668
QYFIEAHEIQWDYGP	HEPH	381	Q9BQS7
YEPVQPHWFYCKEVE	SEC23IP	266	Q9Y6Y8
EEPKHWCSIVYYELN	SMAD5	266	Q99717
EEPKHWCSIVYYELN	SMAD1	266	Q15797
EENIEVYHSYFWPLE	TXNRD1	546	Q16881
IEPWEDADYLVYKVT	USP6NL	31	Q92738
GNEVYVWIYDPVHFK	SEC62	181	Q99442
AAKEWPDVYYVGADV	THUMPD2	316	Q9BTF0
EWFVQLYYHGKEQVP	ACP6	371	Q9NPH0
WATHVYVPYEAKEEF	USB1	81	Q9BQ65
HSTPIEWYLDYEVEA	TSPY8	231	P0CW00
YVWNVEVYPEFEDQR	WDR62	406	O43379
PDTKEEWEQHYSQLY	TGS1	231	Q96RS0
YDFKEERWHQVAELP	KLHL2	326	O95198
EEYQREGIPWKHIDY	MYO1D	421	O94832