Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2M7 OR7C2 OR4K13 FZD3 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1	1.49e-21	884	93	33	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	2.52e-18	431	93	23	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	FLT4 OR2M7 OR7C2 OR4K13 FZD3 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1	6.80e-17	1353	93	34	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR5B12 OR5AN1 OR5A1 OR14C36 OR6K6 OR12D3 OR5J2 OR8B12	1.39e-07	127	93	8	GO:0005549
GeneOntologyMolecularFunction	exoribonuclease II activity	DIS3L HELZ2	6.42e-05	3	93	2	GO:0008859
GeneOntologyMolecularFunction	3'-5'-RNA exonuclease activity	DIS3L2 DIS3L HELZ2	6.78e-04	37	93	3	GO:0000175
GeneOntologyMolecularFunction	RNA exonuclease activity, producing 5'-phosphomonoesters	DIS3L2 DIS3L HELZ2	8.53e-04	40	93	3	GO:0016896
GeneOntologyMolecularFunction	RNA exonuclease activity	DIS3L2 DIS3L HELZ2	1.20e-03	45	93	3	GO:0004532
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	1.32e-18	432	93	23	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	6.69e-18	465	93	23	GO:0007608
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	PDE3B OR2M7 OR7C2 OR4K13 FZD3 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1 GNB3	7.73e-18	1395	93	35	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	1.69e-17	485	93	23	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	9.14e-17	524	93	23	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	2.32e-16	547	93	23	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	8.86e-16	582	93	23	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 NAIP OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	8.78e-15	722	93	24	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	2.63e-10	1072	93	23	GO:0007600
GeneOntologyBiologicalProcess	cellular response to thyroid hormone stimulus	GHSR BRD8 GCLC	7.31e-06	9	93	3	GO:0097067
GeneOntologyBiologicalProcess	locomotion involved in locomotory behavior	GHSR PPP3CB GNB3	5.76e-05	17	93	3	GO:0031987
GeneOntologyBiologicalProcess	response to thyroid hormone	GHSR BRD8 GCLC	1.11e-04	21	93	3	GO:0097066
GeneOntologyBiologicalProcess	regulation of adenylate cyclase activity	P2RY13 TSHR ADRB3 RXFP1	1.46e-04	59	93	4	GO:0045761
GeneOntologyBiologicalProcess	regulation of cyclase activity	P2RY13 TSHR ADRB3 RXFP1	2.68e-04	69	93	4	GO:0031279
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	PDE3B FPR1 OR4M1 TSHR CHRM2 ADRB3 RXFP1	3.14e-04	286	93	7	GO:0007188
GeneOntologyBiologicalProcess	regulation of lyase activity	P2RY13 TSHR ADRB3 RXFP1	3.32e-04	73	93	4	GO:0051339
Domain	GPCR_Rhodpsn_7TM	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1	3.03e-22	670	92	31	IPR017452
Domain	7tm_1	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1	4.12e-22	677	92	31	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1	5.83e-22	685	92	31	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1	7.53e-22	691	92	31	PS50262
Domain	GPCR_Rhodpsn	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 FPR1 OR5AN1 OR4F4 OR4M1 P2RY13 OR5A1 OR2M5 TSHR OR2M3 OR14C36 SUCNR1 CHRM2 BDKRB2 OR6K6 OR1F1 OR12D3 GHSR OR4F5 OR5J2 ADRB3 OR10G2 OR2D2 OR4F17 OR8B12 OR4B1 RXFP1	7.86e-22	692	92	31	IPR000276
Domain	Olfact_rcpt	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR2D2 OR4F17 OR8B12 OR4B1	1.72e-17	393	92	22	IPR000725
Domain	RNase_II/R_CS	DIS3L2 DIS3L HELZ2	4.61e-07	4	92	3	IPR022966
Domain	Nck-associated_protein-1	NCKAP1 NCKAP1L	2.40e-05	2	92	2	IPR019137
Domain	Nckap1	NCKAP1 NCKAP1L	2.40e-05	2	92	2	PF09735
Domain	Rrp44_CSD1	DIS3L2 DIS3L	7.18e-05	3	92	2	IPR033771
Domain	RIBONUCLEASE_II	DIS3L2 DIS3L	7.18e-05	3	92	2	PS01175
Domain	Rrp44_CSD1	DIS3L2 DIS3L	7.18e-05	3	92	2	PF17216
Domain	RDM	RFPL1 RFPL3	2.38e-04	5	92	2	PF11002
Domain	RDM_domain_RFPL	RFPL1 RFPL3	2.38e-04	5	92	2	IPR022723
Domain	BIR	NAIP BIRC6	6.59e-04	8	92	2	SM00238
Domain	-	NAIP BIRC6	6.59e-04	8	92	2	1.10.1170.10
Domain	BIR	NAIP BIRC6	6.59e-04	8	92	2	PF00653
Domain	BIR_REPEAT_2	NAIP BIRC6	6.59e-04	8	92	2	PS50143
Domain	BIR_rpt	NAIP BIRC6	6.59e-04	8	92	2	IPR001370
Domain	BIR_REPEAT_1	NAIP BIRC6	6.59e-04	8	92	2	PS01282
Domain	NA-bd_OB-fold	DIS3L2 DIS3L GCLC HELZ2	7.53e-04	83	92	4	IPR012340
Domain	ABC_A	ABCA3 ABCA8	1.53e-03	12	92	2	IPR026082
Domain	ABC_transporter-like	ABCA3 ABCA8 SMC1B	1.92e-03	50	92	3	IPR003439
Domain	RCC1	MYCBP2 HERC4	4.30e-03	20	92	2	PF00415
Domain	RCC1_1	MYCBP2 HERC4	4.74e-03	21	92	2	PS00625
Domain	RCC1_2	MYCBP2 HERC4	4.74e-03	21	92	2	PS00626
Domain	RCC1_3	MYCBP2 HERC4	4.74e-03	21	92	2	PS50012
Domain	Reg_chr_condens	MYCBP2 HERC4	5.20e-03	22	92	2	IPR000408
Domain	-	MYCBP2 HERC4	5.20e-03	22	92	2	2.130.10.30
Domain	AAA+_ATPase	ABCA3 NAIP ABCA8 HELZ2	5.61e-03	144	92	4	IPR003593
Domain	AAA	ABCA3 NAIP ABCA8 HELZ2	5.61e-03	144	92	4	SM00382
Domain	RCC1/BLIP-II	MYCBP2 HERC4	5.68e-03	23	92	2	IPR009091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1	2.09e-17	417	77	23	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR2D2 OR4F17 OR8B12 OR4B1	7.02e-17	389	77	22	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR4F5 OR5J2 OR10G2 OR1P1 OR2D2 OR4F17 OR8B12 OR4B1 GNB3	1.90e-14	636	77	24	M41834
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	OR7C2 OR7C1 FPR1 P2RY13 SUCNR1 CHRM2 BDKRB2 OR1F1 OR12D3 GHSR ADRB3 OR2D2	1.53e-08	260	77	12	M39397
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	FPR1 P2RY13 TSHR SUCNR1 CHRM2 BDKRB2 ADRB3 OR2D2 OR8B12	7.44e-07	186	77	9	MM15994
Pathway	WP_GPCRS_NONODORANT	FZD3 FPR1 P2RY13 TSHR SUCNR1 CHRM2 BDKRB2 GHSR ADRB3 RXFP1	1.74e-06	266	77	10	MM15843
Pathway	BIOCARTA_NO1_PATHWAY	PDE3B FLT4 BDKRB2 SLC7A1	1.53e-05	28	77	4	M4383
Pathway	REACTOME_GPCR_LIGAND_BINDING	FZD3 FPR1 P2RY13 TSHR SUCNR1 CHRM2 BDKRB2 GHSR ADRB3 RXFP1 GNB3	4.02e-05	463	77	11	M507
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	FPR1 P2RY13 TSHR SUCNR1 CHRM2 BDKRB2 GHSR ADRB3 RXFP1	7.53e-05	330	77	9	M18334
Pathway	REACTOME_SIGNALING_BY_GPCR	PDE3B FZD3 FPR1 P2RY13 TSHR SUCNR1 CHRM2 BDKRB2 GHSR ADRB3 PPP3CB RXFP1 GNB3	9.96e-05	702	77	13	M746
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	FPR1 P2RY13 TSHR CHRM2 BDKRB2 GHSR ADRB3 RXFP1	1.15e-04	272	77	8	M13380
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	FPR1 P2RY13 TSHR SUCNR1 CHRM2 BDKRB2 ADRB3 RXFP1	4.55e-04	333	77	8	MM14963
Pathway	REACTOME_GPCR_LIGAND_BINDING	FPR1 P2RY13 TSHR SUCNR1 CHRM2 BDKRB2 ADRB3 RXFP1 GNB3	5.41e-04	430	77	9	MM15160
Pathway	WP_GPCRS_PEPTIDE	FPR1 TSHR BDKRB2 GHSR	5.74e-04	70	77	4	MM15959
Pathway	WP_PEPTIDE_GPCRS	FPR1 TSHR BDKRB2 GHSR	7.46e-04	75	77	4	M39696
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2M7 OR7C2 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR5J2 OR10G2 OR1P1 OR2D2 OR8B12 OR4B1	5.95e-21	343	97	20	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2M7 OR7C2 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR5J2 OR10G2 OR1P1 OR2D2 OR8B12 OR4B1	7.07e-21	346	97	20	14611657
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2M7 OR7C2 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR1F1 OR12D3 OR5J2 OR10G2 OR1P1 OR2D2 OR8B12 OR4B1	1.37e-19	340	97	19	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2M7 OR7C2 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR1F1 OR12D3 OR5J2 OR10G2 OR1P1 OR2D2 OR8B12 OR4B1	1.37e-19	340	97	19	11802173
Pubmed	The human olfactory receptor gene family.	OR2M7 OR7C2 OR4K13 OR7C1 OR5B12 OR5AN1 OR4F4 OR4M1 OR5A1 OR2M5 OR2M3 OR14C36 OR6K6 OR1F1 OR12D3 OR5J2 OR10G2 OR1P1 OR2D2 OR8B12 OR4B1	2.43e-18	541	97	21	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR7C2 OR7C1 OR5B12 OR4F4 OR5A1 OR2M3 OR1F1 OR1P1 OR2D2 OR8B12 OR4B1	2.97e-11	219	97	11	12213199
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR7C2 OR7C1 OR5AN1 OR14C36 OR6K6 OR4B1	6.40e-08	74	97	6	15081110
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M7 OR2M5 OR2M3	8.40e-08	4	97	3	15377787
Pubmed	Association study of adrenergic beta3 receptor (Trp64Arg) and G-protein beta3 subunit gene (C825T) polymorphisms and weight change during clozapine treatment.	ADRB3 GNB3	7.70e-06	2	97	2	15179018
Pubmed	Beta3 adrenoceptors substitute the role of M(2) muscarinic receptor in coping with cold stress in the heart: evidence from M(2)KO mice.	CHRM2 ADRB3	7.70e-06	2	97	2	22222438
Pubmed	Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.	OR4F4 OR4F17	7.70e-06	2	97	2	11689484
Pubmed	Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.	OR4F4 OR4F17	7.70e-06	2	97	2	11689483
Pubmed	Is there an interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms and elite athletic performance?	BDKRB2 GNB3	7.70e-06	2	97	2	21210858
Pubmed	The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis.	NCKAP1 NCKAP1L	7.70e-06	2	97	2	7643388
Pubmed	Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.	PDE3B PPP3CB	2.31e-05	3	97	2	23258544
Pubmed	HELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of the RNB family is expressed from a non-canonical initiation codon.	DIS3L HELZ2	2.31e-05	3	97	2	37602378
Pubmed	Impact of variation in ADRB2, ADRB3, and GNB3 genes on body mass index and waist circumference in a Brazilian population.	ADRB3 GNB3	2.31e-05	3	97	2	16493638
Pubmed	Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.	RFPL1 RFPL3	2.31e-05	3	97	2	18656177
Pubmed	Transcriptome sequencing of the anterior cingulate in bipolar disorder: dysregulation of G protein-coupled receptors.	CHRM2 RXFP1	2.31e-05	3	97	2	26238605
Pubmed	Knockdown of FLT4, Nup98, and Nup205 Cellular Genes Effectively Suppresses the Reproduction of Influenza Virus Strain A/WSN/1933 (H1N1) In vitro.	FLT4 NUP205	2.31e-05	3	97	2	35339191
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR7C2 OR7C1 OR1F1	3.58e-05	23	97	3	10706615
Pubmed	IAPs: more than just inhibitors of apoptosis proteins.	NAIP BIRC6	4.60e-05	4	97	2	18414036
Pubmed	[Myocardial hypertrophy in patients with hypertensive disease: the role of genetic polymorphism of beta-adrenoreactive structures].	ADRB3 GNB3	4.60e-05	4	97	2	20144152
Pubmed	Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.	OR4F4 OR4F17	4.60e-05	4	97	2	9384599
Pubmed	Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality.	CHRM2 ADRB3	4.60e-05	4	97	2	18245567
Pubmed	Contribution of several candidate gene polymorphisms in the determination of adiposity changes: results from the Québec Family Study.	ADRB3 GNB3	4.60e-05	4	97	2	17299381
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYCBP2 HECTD4 GRB10 BIRC6 SLC7A1 HEG1 OVOL1 HELZ2 ANKRD11 TP53I13 ATG9A CREB3	5.93e-05	1105	97	12	35748872
Pubmed	Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts.	RFPL1 RFPL3	7.66e-05	5	97	2	10508838
Pubmed	ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancer.	ABCA3 ABCA8	7.66e-05	5	97	2	28468577
Pubmed	The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.	RFPL1 RFPL3	7.66e-05	5	97	2	11850190
Pubmed	An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.	P2RY13 SUCNR1	7.66e-05	5	97	2	11273702
Pubmed	Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA.	DIS3L2 DIS3L	1.15e-04	6	97	2	23756462
Pubmed	SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study.	BDKRB2 GNB3	1.15e-04	6	97	2	20944660
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	MYCBP2 HECTD4 RNF14 HERC4	1.49e-04	95	97	4	29643511
Pubmed	The inhibitors of apoptosis (IAPs) and their emerging role in cancer.	NAIP BIRC6	1.60e-04	7	97	2	9916987
Pubmed	IAP family proteins--suppressors of apoptosis.	NAIP BIRC6	1.60e-04	7	97	2	9990849
Pubmed	The small-subunit processome is a ribosome assembly intermediate.	EMG1 UTP20	2.13e-04	8	97	2	15590835
Pubmed	NFATc1 regulates lymphatic endothelial development.	FLT4 PPP3CB	2.13e-04	8	97	2	19233265
Pubmed	RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.	RFPL1 RFPL3	2.13e-04	8	97	2	12525704
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	P2RY13 TSHR CHRM2 BDKRB2 ADRB3	2.51e-04	200	97	5	18240029
Pubmed	Sensitivity-dependent hierarchical receptor codes for odors.	OR5AN1 OR8B12	2.74e-04	9	97	2	12588732
Pubmed	A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity.	NCKAP1 NCKAP1L	2.74e-04	9	97	2	19015308
Pubmed	Expression of olfactory receptors, G-proteins and AxCAMs during the development and maturation of olfactory sensory neurons in the mouse.	OR5A1 GNB3	3.41e-04	10	97	2	9733924
Pubmed	Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.	ADRB3 GNB3	3.41e-04	10	97	2	18426866
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	SRM NT5DC3 NUP205 WDR75 EMG1 UTP20	3.91e-04	340	97	6	29478914
Pubmed	Defining the membrane proteome of NK cells.	DNAJB11 PDE3B MYCBP2 BIRC6 NUP205 SLC7A1 IER3IP1 HELZ2 STAMBPL1 ATG9A NCKAP1L	4.16e-04	1168	97	11	19946888
Pubmed	Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.	OR5AN1 OR8B12	4.17e-04	11	97	2	26361056
Pubmed	Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.	ADRB3 GNB3	4.17e-04	11	97	2	19779464
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DIS3L NDRG2 BIRC6 ABCA8 DENND3 HELZ2 LRRCC1	4.72e-04	493	97	7	15368895
Pubmed	A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.	HECTD4 CD46	4.99e-04	12	97	2	19396169
Pubmed	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	FZD3 BIRC6 ATG9A SMC1B	6.52e-04	140	97	4	20819778
Pubmed	Nucleolar maturation of the human small subunit processome.	WDR75 EMG1 UTP20	7.06e-04	62	97	3	34516797
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ABCA3 TSHR NDRG2 CHRM2 BDKRB2 BRD8 ENTPD6 SDHD	7.55e-04	697	97	8	28298427
Pubmed	CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.	GRB10 TSHR GHSR ADRB3	7.63e-04	146	97	4	29688375
Pubmed	Identification of candidate genes at the corticoseptal boundary during development.	NDRG2 CREB3	7.89e-04	15	97	2	16458080
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	NAIP RFPL1 NDRG2 BIRC6 RNF14 OVOL1 RFPL3 CREB3	8.43e-04	709	97	8	22988430
Pubmed	Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.	BDKRB2 ADRB3 GCLC GNB3	8.86e-04	152	97	4	19578796
Pubmed	Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.	PDE3B P2RY13	9.01e-04	16	97	2	27721240
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	ADRB3 GNB3	9.01e-04	16	97	2	15824464
Pubmed	Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.	EMG1 GNB3	9.01e-04	16	97	2	9445485
Pubmed	Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.	TSHR ADRB3 RXFP1	1.01e-03	70	97	3	12036966
Pubmed	Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study.	ADRB3 GNB3	1.02e-03	17	97	2	19193342
Pubmed	Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study.	BDKRB2 GNB3	1.02e-03	17	97	2	20952631
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PDE3B CAMSAP3 BIRC6 NUP205 UTP20 OR4B1 CHD6 RXFP1	1.07e-03	736	97	8	29676528
Pubmed	Chromosomal mapping of Adam9, Adam15 and Adam21.	ADRB3 PIGH	1.14e-03	18	97	2	10842103
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	DIS3L2 SRM BIRC6 NUP205 SLC7A1 BRD8 PIGH GCLC IER3IP1 ANKRD11 ATG9A	1.18e-03	1327	97	11	32694731
Pubmed	Can we predict top-level sports performance in power vs endurance events? A genetic approach.	ADRB3 GNB3	1.42e-03	20	97	2	20459474
Pubmed	Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.	EMG1 GNB3	1.42e-03	20	97	2	9074930
Pubmed	Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.	FLT4 TSHR	1.56e-03	21	97	2	23707896
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	DIS3L2 HECTD4 HMGCS2 HERC4	1.76e-03	183	97	4	31932471
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCA3 ABCA8	1.87e-03	23	97	2	10708515
Pubmed	Lymphatic function is required prenatally for lung inflation at birth.	FLT4 ABCA3	2.04e-03	24	97	2	24733830
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR7C1 OR4B1	2.04e-03	24	97	2	9119360
Pubmed	Gene expression analysis of the embryonic subplate.	GRB10 LRRTM3 ABCA8 HEG1	2.25e-03	196	97	4	21862448
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NCKAP1 MYCBP2 BIRC6 NUP205 WDR75 HELZ2 UTP20	2.38e-03	653	97	7	22586326
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	NUP205 WDR75 HELZ2 EMG1 UTP20	2.42e-03	332	97	5	25693804
Pubmed	A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.	ABCA3 NDRG2	2.78e-03	28	97	2	25912685
Pubmed	Distribution of olfactory receptor genes in the human genome.	OR7C2 OR1F1	2.78e-03	28	97	2	9500546
Cytoband	1q44	OR2M7 OR2M5 OR2M3 OR14C36 LYPD8	3.90e-06	110	97	5	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2M7 OR2M5 OR2M3 OR14C36 LYPD8	8.17e-06	128	97	5	chr1q44
Cytoband	14q11.2	OR4K13 OR4M1 NDRG2 OR10G2	5.96e-04	180	97	4	14q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q32	NCKAP1 FSIP2 WDR75	1.68e-03	110	97	3	chr2q32
Cytoband	10q21.3	LRRTM3 HERC4	2.37e-03	34	97	2	10q21.3
GeneFamily	Olfactory receptors, family 4	OR4K13 OR4F4 OR4M1 OR4F5 OR4F17 OR4B1	9.74e-06	129	69	6	151
GeneFamily	Ring finger proteins\|Baculoviral IAP repeat containing\|Caspase recruitment domain containing	NAIP BIRC6	3.96e-04	8	69	2	419
GeneFamily	Olfactory receptors, family 5	OR5B12 OR5AN1 OR5A1 OR5J2	8.85e-04	112	69	4	152
GeneFamily	Olfactory receptors, family 2	OR2M7 OR2M5 OR2M3 OR2D2	9.15e-04	113	69	4	149
GeneFamily	ATP binding cassette subfamily A	ABCA3 ABCA8	1.27e-03	14	69	2	805
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT4 GRB10 HEG1 PLA1A IER3IP1 RXFP1	1.91e-06	169	97	6	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FPR1 NAIP P2RY13 SUCNR1 DENND3 PLA1A	3.03e-06	183	97	6	614a1c08cf6d01a4f1ed2fb816cd1a6e0c3207ce
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FPR1 NAIP P2RY13 SUCNR1 NDRG2 ADRB3	5.05e-06	200	97	6	f0e7c2f07a7065511bf0b6521ce2e74e04e48544
Disease	uric acid measurement	FLT4 HECTD4 GRB10 TSHR HMGCS2 BIRC6 OVOL1 UMOD HERC4	6.03e-05	610	84	9	EFO_0004761
Disease	sensory perception of smell	OR2M7 OR5A1 OR14C36	7.71e-05	29	84	3	GO_0007608
Disease	forced expiratory volume, body mass index	DIS3L2 HECTD4	4.33e-04	11	84	2	EFO_0004314, EFO_0004340
Disease	Cystic Kidney Diseases	DNAJB11 UMOD	4.33e-04	11	84	2	C1691228
Disease	cystatin C measurement	HECTD4 SRM OVOL1 ENTPD6 ANKRD11 UMOD	1.02e-03	402	84	6	EFO_0004617
Disease	Hypertensive disease	BDKRB2 GCLC UMOD GNB3	2.15e-03	190	84	4	C0020538

Protein segments in the cluster

Peptide	Gene	Start	Entry
RELPMASAYCNDSIF	NAIP	261	Q13075
IASFMAYSNSCLNPL	BDKRB2	316	P30411
PFSACTMLLDSEVYN	ANKRD11	2551	Q6UB99
ANLLQTCAALLMSPY	BIRC6	3356	Q9NR09
SEVAYLMEPLCISSN	BRD8	951	Q9H0E9
SLLAACALMAGALYP	CCDC171	726	Q6TFL3
LLAINYSSELFDDPM	ABCA3	941	Q99758
ACADLIIGVFSMNLY	CHRM2	66	P08172
CAFASNMPYVLLSSS	ADRB3	196	P13945
NPCSAMDYSLAAALT	SDHD	86	O14521
LSEAMCFLAPDNSLL	DENND3	541	A2RUS2
MALYFCSGLLQDPAQ	DIS3L2	671	Q8IYB7
CLKDPMSVADSLYNL	CAMSAP3	256	Q9P1Y5
LALLAYACMANPSLT	TP53I13	81	Q8NBR0
YACMANPSLTPDFSL	TP53I13	86	Q8NBR0
MAFTLYSLLQAALLC	IER3IP1	1	Q9Y5U9
AVNLALLMALLYCFD	NUP205	266	Q92621
YLLHCMPTDSQDSLF	NUP205	1911	Q92621
LAAMVLLLYSFSDAC	CD46	21	P15529
LYELCALMPPFTAFS	NEK2	206	P51955
PLLTCIYDMLLSSEN	FSIP2	1356	Q5CZC0
TLDDLQYMIFHTPFC	HMGCS2	291	P54868
PMYFFLRNLSILDAC	OR14C36	56	Q8NHC7
SLLGSECFLLAVMAY	OR2M3	106	Q8NG83
SLLGSECFLLAVMSY	OR2M5	106	A3KFT3
SLLGSECFLLAVMSY	OR2M7	106	Q8NG81
PMYFLLANLSLIDLS	OR4F5	51	Q8NH21
HTPMYFLLSNLSCID	OR4K13	56	Q8NH42
TSPMYFLLANLALLD	OR4M1	56	Q8NGD0
FIDICYSSAVAPNML	OR5A1	71	Q8NGJ0
CLSSNIPALELMALY	PDE3B	801	Q13370
FYLTLPECPLMSDSN	HERC4	506	Q5GLZ8
MNFYLLLASSILCAL	CT83	1	Q5H943
YDQLATICPIVMALS	GCLC	266	P48506
ALTFPSLQRLVYSMC	NSUN5P2	161	Q63ZY6
SSFLTLDMLESCFPY	NCKAP1L	1096	P55160
DCMSLAVSPDFNLFI	GNB3	186	P16520
ITKTLNMCFSALPSY	HEG1	1096	Q9ULI3
PMYFLLANLSLIDLS	OR4F17	51	Q8NGA8
PLLTLSCSDNYISEM	OR5B12	181	Q96R08
HTPMYFLLSCLSFVD	OR5J2	56	Q8NH18
ACYSSAIAPKMLVNL	OR5J2	71	Q8NH18
PAASSCLRYLMAVQN	HECTD4	441	Q9Y4D8
DMPQLLILSCTDTFF	OR5AN1	181	Q8NGI8
ALSELCFSINYVPNM	NCKAP1	681	Q9Y2A7
SCPLALNMSLRDSSY	OVOL1	56	O14753
LLMAPLSFCADNAIT	OR1F1	161	O43749
PMYFFLGNLSCLDIS	OR12D3	56	Q9UGF7
HTPMYFFLCNLSLAD	OR2D2	56	Q9H210
AATNICMDPLIYIFL	P2RY13	306	Q9BPV8
LPLLELSCNSSYMNE	OR8B12	181	Q8NGG6
SFGCLDNLLLTVMAY	OR7C1	106	O76099
YLSSMAFSDLLIFLC	GHSR	81	Q92847
TDCYIMNDPQLSFLD	CHD6	1596	Q8TD26
YDMLPSVLSADLCSL	DIS3L	536	Q8TF46
ASKYMNCFLSPLLTL	ATG9A	361	Q7Z3C6
SAPLFMLDLYNALSA	BMP6	131	P22004
MAPQNLSTFCLLLLY	DNAJB11	1	Q9UBS4
SLETPVRLYQNMFCS	LYPD8	56	Q6UX82
ITLRMCQDLPYNTTF	FZD3	31	Q9NPG1
LYSACSMQSDTVPLL	GRB10	66	Q13322
LQPLELSYEACMSLS	CA7	46	P43166
QMLECEALTPLAYAS	HELZ2	671	Q9BYK8
VSFCLLLVPAMYSSD	CREB3	236	O43889
ACMEAFDSLPLAALL	PPP3CB	186	P16298
LAMAPFDVACTRLYN	SLC25A35	221	Q3KQZ1
VAASCFMLILLSYAN	OR10G2	211	Q8NGC3
AFGCLDNLLLTMTAY	OR7C2	106	O60412
SNYRSLLFPFLCSQM	OR6K6	11	Q8NGW6
TPMYFFLASLSCADI	OR1P1	71	Q8NH06
PMYFFLSCLSLVEIS	OR4B1	56	Q8NGF8
PMYFLLANLSLIDLS	OR4F4	51	Q96R69
FFIPLCLMTINDDSA	UTP20	2326	O75691
LCTFPLAVDMAALFQ	RFPL1	21	O75677
SPFSCMDLTYVSLLL	ENTPD6	426	O75354
CEIPLSMNVSTFLAY	LRRTM3	511	Q86VH5
DMIPCVLQYLNFSTI	NDRG2	126	Q9UN36
LPEMTLLSCVNEYFL	NT5DC3	221	Q86UY8
TSALAFFNSCLNPML	FPR1	286	P21462
AYCFELLSMVLALSG	MYCBP2	4011	O75592
TNFMLAFDTCLYLAL	ABCA8	401	O94911
LYISALENSCPLMAF	PLA1A	266	Q53H76
LQSSLDLMADVVYCP	RNF14	296	Q9UBS8
LMCNLDFTPNAYLAR	ZNF815P	81	A8K554
INFACSYPLDMKVSL	UMOD	421	P07911
LSRFALLMTNCYATP	UMOD	496	P07911
CMFSRVLTLDLSQYP	SMC1B	1206	Q8NDV3
SLYLCLVMEFNELSF	STKLD1	101	Q8NE28
LPSAAFLCSMFVNSL	WDR75	741	Q8IWA0
AALTLMMPYFCLDNN	SLC7A1	306	P30825
SYQLMLPEAIAIVCS	STAMBPL1	366	Q96FJ0
LSPLTMEDLVCYSFQ	FLT4	1006	P35916
AAYGLFTLCENSMIL	PIGH	51	Q14442
DLFTYPCEMSLISQS	RXFP1	736	Q9HBX9
LCTFPLAVDMAALFQ	RFPL3	21	O75679
EFSYQEMIANLPLCS	SRM	76	P19623
AFLCTLPMLIRSYAN	SUCNR1	71	Q9BXA5
MVSISNYPLSAALTC	EMG1	216	Q92979
MIAPLLCILSYNFNT	ZBED5	1	Q49AG3
CMAPISFYALSAILN	TSHR	636	P16473
KELYVSSSLANCPML	LRRCC1	386	Q9C099