Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3-oxoacyl-[acyl-carrier-protein] synthase activity	FASN OXSM	7.90e-05	2	178	2	GO:0004315
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ADGRB3 GMIP CHM CHML SYDE2 RASA4B DOCK6 AGAP2 RGS12 DENND3 NPRL2 ARHGEF40 RASA4 RAB3IP	1.88e-04	507	178	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ADGRB3 GMIP CHM CHML SYDE2 RASA4B DOCK6 AGAP2 RGS12 DENND3 NPRL2 ARHGEF40 RASA4 RAB3IP	1.88e-04	507	178	14	GO:0030695
GeneOntologyMolecularFunction	GTPase activator activity	ADGRB3 GMIP CHM CHML SYDE2 RASA4B AGAP2 RGS12 NPRL2 RASA4	2.10e-04	279	178	10	GO:0005096
GeneOntologyCellularComponent	IgM immunoglobulin complex, circulating	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	2.82e-09	8	185	5	GO:0071754
GeneOntologyCellularComponent	pentameric IgM immunoglobulin complex	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	2.82e-09	8	185	5	GO:0071756
GeneOntologyCellularComponent	monomeric IgA immunoglobulin complex	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	6.30e-09	9	185	5	GO:0071748
GeneOntologyCellularComponent	polymeric IgA immunoglobulin complex	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	1.25e-08	10	185	5	GO:0071749
GeneOntologyCellularComponent	IgA immunoglobulin complex, circulating	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	1.25e-08	10	185	5	GO:0071746
GeneOntologyCellularComponent	secretory IgA immunoglobulin complex	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	1.25e-08	10	185	5	GO:0071751
GeneOntologyCellularComponent	IgA immunoglobulin complex	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	1.44e-07	15	185	5	GO:0071745
GeneOntologyCellularComponent	IgM immunoglobulin complex	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	1.44e-07	15	185	5	GO:0071753
GeneOntologyCellularComponent	immunoglobulin complex, circulating	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	2.92e-07	17	185	5	GO:0042571
GeneOntologyCellularComponent	immunoglobulin complex	IGLV11-55 IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-7 IGHV3-49	1.76e-05	166	185	9	GO:0019814
GeneOntologyCellularComponent	Rab-protein geranylgeranyltransferase complex	CHM CHML	4.62e-04	4	185	2	GO:0005968
Domain	Ketoacyl-synt_C	FASN OXSM	8.43e-05	2	172	2	PF02801
Domain	PKS_Beta-ketoAc_synthase_dom	FASN OXSM	8.43e-05	2	172	2	IPR020841
Domain	ketoacyl-synt	FASN OXSM	8.43e-05	2	172	2	PF00109
Domain	Rab_escort	CHM CHML	8.43e-05	2	172	2	IPR001738
Domain	PKS_KS	FASN OXSM	8.43e-05	2	172	2	SM00825
Domain	B_KETOACYL_SYNTHASE	FASN OXSM	8.43e-05	2	172	2	PS00606
Domain	Ketoacyl_synth_AS	FASN OXSM	8.43e-05	2	172	2	IPR018201
Domain	Ketoacyl_synth_N	FASN OXSM	8.43e-05	2	172	2	IPR014030
Domain	Ketoacyl_synth_C	FASN OXSM	8.43e-05	2	172	2	IPR014031
Domain	-	APC2 CLASP2 ARMC2 BRAT1 AP3D1 HEATR4 WDFY4 HEATR6 AP4B1	2.22e-04	222	172	9	1.25.10.10
Domain	Ppantetheine_attach_site	NDUFAB1 FASN	2.51e-04	3	172	2	IPR006162
Domain	-	RASA4B RASA4	2.51e-04	3	172	2	4.10.1130.10
Domain	ARM-type_fold	APC2 CLASP2 ARMC2 BRAT1 AP3D1 HEATR4 USP24 WDFY4 HEATR6 RNPEP AP4B1	3.15e-04	339	172	11	IPR016024
Domain	HEAT_REPEAT	CLASP2 BRAT1 AP3D1 HEATR4 HEATR6	4.66e-04	70	172	5	PS50077
Domain	C345C	C4A C4B NTN3	4.75e-04	17	172	3	SM00643
Domain	GDI	CHM CHML	5.00e-04	4	172	2	PF00996
Domain	GDP_dissociation_inhibitor	CHM CHML	5.00e-04	4	172	2	IPR018203
Domain	NTR	C4A C4B NTN3	6.67e-04	19	172	3	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B NTN3	6.67e-04	19	172	3	IPR018933
Domain	NEUZ	NEURL1 NEURL4	8.28e-04	5	172	2	SM00588
Domain	Anaphylatoxin_comp_syst	C4A C4B	8.28e-04	5	172	2	IPR018081
Domain	NHR	NEURL1 NEURL4	8.28e-04	5	172	2	PS51065
Domain	-	NDUFAB1 FASN	8.28e-04	5	172	2	1.10.1200.10
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	8.28e-04	5	172	2	IPR001840
Domain	RDM_domain_RFPL	RFPL4AL1 RFPL4A	8.28e-04	5	172	2	IPR022723
Domain	NHR_dom	NEURL1 NEURL4	8.28e-04	5	172	2	IPR006573
Domain	PHOSPHOPANTETHEINE	NDUFAB1 FASN	8.28e-04	5	172	2	PS00012
Domain	RDM	RFPL4AL1 RFPL4A	8.28e-04	5	172	2	PF11002
Domain	PP-binding	NDUFAB1 FASN	8.28e-04	5	172	2	PF00550
Domain	ACP_DOMAIN	NDUFAB1 FASN	8.28e-04	5	172	2	PS50075
Domain	Neuralized	NEURL1 NEURL4	8.28e-04	5	172	2	PF07177
Domain	ARM-like	APC2 CLASP2 ARMC2 BRAT1 AP3D1 HEATR4 WDFY4 HEATR6 AP4B1	9.14e-04	270	172	9	IPR011989
Domain	NTR	C4A C4B NTN3	1.19e-03	23	172	3	PS50189
Domain	Netrin_domain	C4A C4B NTN3	1.19e-03	23	172	3	IPR001134
Domain	PP-bd_ACP	NDUFAB1 FASN	1.23e-03	6	172	2	IPR009081
Domain	TIMP-like_OB-fold	C4A C4B NTN3	1.71e-03	26	172	3	IPR008993
Domain	ANATO	C4A C4B	1.72e-03	7	172	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	1.72e-03	7	172	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.72e-03	7	172	2	PS01177
Domain	ANATO	C4A C4B	1.72e-03	7	172	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	1.72e-03	7	172	2	IPR000020
Domain	-	CHM CHML MTO1 AIFM1	1.76e-03	56	172	4	3.50.50.60
Domain	FAD/NAD-binding_dom	CHM CHML MTO1 AIFM1	1.88e-03	57	172	4	IPR023753
Pubmed	Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences.	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	3.06e-11	6	194	5	4691517
Pubmed	Primary structures of N-terminal extra peptide segments linked to the variable and constant regions of immunoglobulin light chain precursors: implications on the organization and controlled expression of immunoglobulin genes.	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	3.06e-11	6	194	5	98179
Pubmed	Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions.	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	3.06e-11	6	194	5	99744
Pubmed	The 3' part of the immunoglobulin kappa locus of the mouse.	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15	1.07e-10	7	194	5	9603450
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KIF26A CLASP2 SPPL2B ITGB5 PRR12 FASN A4GALT CACNA1H BRAT1 DOCK6 AP3D1 MRPL21 LRFN1 CDC42BPA SH3RF1 TLNRD1 SEPHS2 ARHGEF40 IGF2R CELSR2 ENTPD2 LRRC14 ESPL1 ATP2A3	1.52e-08	1105	194	24	35748872
Pubmed	Immunoglobulin genes of different subgroups are interdigitated within the VK locus.	IGKV3D-11 IGKV3-11 IGKV3-7	1.71e-07	3	194	3	6440122
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PDE3B ATG13 CLASP2 MAST4 SYDE2 DOCK6 CDC42BPA SH3RF1 KIF26B CBX4 INPP5F RGS12 CDC42EP1 FAM171A1 AKAP9 MAP4K1 NEURL1 SRRM2	1.83e-06	861	194	18	36931259
Pubmed	The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line.	IGKV3D-15 IGKV3D-11 IGKV3-11 IGKV3-7	2.11e-06	17	194	4	8223863
Pubmed	IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes.	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGHV3-49	4.76e-06	77	194	6	15608191
Pubmed	Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.	MCC C4A C4B CD70	9.14e-06	24	194	4	11739537
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF26A ADGRB3 PASK MAST4 ZNF608 SULF1 DOCK6 NYAP2 CDC42BPA PHRF1 INPP5F UNK ESPL1	9.71e-06	529	194	13	14621295
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	NAIP ADGRB3 SLC30A3 PRRT3 AGAP2 HSPA4L GRIN2A RAB3IP SRRM2 SNTB2	2.79e-05	347	194	10	17114649
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	3.10e-05	2	194	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	3.10e-05	2	194	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	3.10e-05	2	194	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	3.10e-05	2	194	2	19062096
Pubmed	TWEAK affects keratinocyte G2/M growth arrest and induces apoptosis through the translocation of the AIF protein to the nucleus.	TNFSF12 AIFM1	3.10e-05	2	194	2	22438963
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	3.10e-05	2	194	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	3.10e-05	2	194	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	3.10e-05	2	194	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	3.10e-05	2	194	2	12207352
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	3.10e-05	2	194	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	3.10e-05	2	194	2	22387014
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4B RASA4	3.10e-05	2	194	2	11448776
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	3.10e-05	2	194	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	3.10e-05	2	194	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	3.10e-05	2	194	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	3.10e-05	2	194	2	11726230
Pubmed	Mouse choroideremia gene mutation causes photoreceptor cell degeneration and is not transmitted through the female germline.	CHM CHML	3.10e-05	2	194	2	9175730
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	3.10e-05	2	194	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	3.10e-05	2	194	2	6950384
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	3.10e-05	2	194	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	3.10e-05	2	194	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	3.10e-05	2	194	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	3.10e-05	2	194	2	21345967
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	3.10e-05	2	194	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	3.10e-05	2	194	2	2302180
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	3.10e-05	2	194	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	3.10e-05	2	194	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	3.10e-05	2	194	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	3.10e-05	2	194	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	3.10e-05	2	194	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	3.10e-05	2	194	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	3.10e-05	2	194	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	3.10e-05	2	194	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	3.10e-05	2	194	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	3.10e-05	2	194	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	3.10e-05	2	194	2	2387317
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	3.10e-05	2	194	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	3.10e-05	2	194	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	3.10e-05	2	194	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	3.10e-05	2	194	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	3.10e-05	2	194	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	3.10e-05	2	194	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	3.10e-05	2	194	2	6881182
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	3.10e-05	2	194	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	3.10e-05	2	194	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	3.10e-05	2	194	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	3.10e-05	2	194	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	3.10e-05	2	194	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	3.10e-05	2	194	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	3.10e-05	2	194	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	3.10e-05	2	194	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	3.10e-05	2	194	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	3.10e-05	2	194	2	32691186
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	3.10e-05	2	194	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	3.10e-05	2	194	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	3.10e-05	2	194	2	7373044
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	3.10e-05	2	194	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	3.10e-05	2	194	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	3.10e-05	2	194	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	3.10e-05	2	194	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	3.10e-05	2	194	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	3.10e-05	2	194	2	6559257
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	3.10e-05	2	194	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	3.10e-05	2	194	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	3.10e-05	2	194	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	3.10e-05	2	194	2	26800705
Pubmed	PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.	GCK PASK	3.10e-05	2	194	2	30038292
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	3.10e-05	2	194	2	15390104
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	3.10e-05	2	194	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	3.10e-05	2	194	2	2997024
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	3.10e-05	2	194	2	3624865
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	3.10e-05	2	194	2	21857912
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	3.10e-05	2	194	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	3.10e-05	2	194	2	4514997
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	3.10e-05	2	194	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	3.10e-05	2	194	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	3.10e-05	2	194	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	3.10e-05	2	194	2	30041577
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	3.10e-05	2	194	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	3.10e-05	2	194	2	34358307
Pubmed	Cloning and characterization of the human choroideremia gene.	CHM CHML	3.10e-05	2	194	2	7981670
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	3.10e-05	2	194	2	18360261
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	3.10e-05	2	194	2	26814963
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	3.10e-05	2	194	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	3.10e-05	2	194	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	3.10e-05	2	194	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	3.10e-05	2	194	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	3.10e-05	2	194	2	6167582
Cytoband	2p12	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	7.23e-07	117	194	7	2p12
Cytoband	Ensembl 112 genes in cytogenetic band chr2p11	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 TRABD2A	3.87e-06	213	194	8	chr2p11
Cytoband	8q24.3	ZC3H3 DENND3 SLC45A4 LRRC14 TIGD5	1.24e-04	113	194	5	8q24.3
Cytoband	17p13	TNFSF12 HASPIN NEURL4	4.04e-04	34	194	3	17p13
GeneFamily	Immunoglobulin kappa locus at 2p11.2	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	8.16e-07	83	112	7	351
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.33e-03	9	112	2	1234
GeneFamily	Complement system\|Sushi domain containing	ITGAX C4A C4B	1.42e-03	36	112	3	492
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4B RASA4	1.66e-03	10	112	2	830
Coexpression	GSE29949_MICROGLIA_BRAIN_VS_CD8_POS_DC_SPLEEN_UP	PDE3B LAPTM4B ZNF318 PASK PRDX3 OSER1 INPP5F IGF2R CD6	1.71e-05	199	192	9	M8396
Coexpression	GSE17721_LPS_VS_POLYIC_12H_BMDC_UP	ITGAX USP24 M1AP SEPHS2 HEATR6 IGF2R AIFM1 NAA30 LRRC14	1.78e-05	200	192	9	M3814
Coexpression	GSE30083_SP2_VS_SP4_THYMOCYTE_UP	TTYH1 LAPTM4B ZNF608 GOT1 LRFN1 KIF26B CD6 TENM4 AIFM1	1.78e-05	200	192	9	M5034
ToppCell	Biopsy_IPF-Immune-Plasma_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	IGLV11-55 IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	1.53e-08	196	193	10	a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	C12orf42 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49 WDFY4	1.60e-08	197	193	10	2662138671262b30508c5759038bcdcfe6551696
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 SPACA3	6.89e-08	173	193	9	7e6bfe85f60834f317941b70d6e0dc3bd527d293
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49 SPACA3	8.39e-08	177	193	9	4c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49 SPACA3	8.39e-08	177	193	9	d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49 SPACA3	8.39e-08	177	193	9	fc40918825b7e1eb6861df59dfca944778a64b98
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49 SPACA3	9.23e-08	179	193	9	837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49 SPACA3	9.23e-08	179	193	9	b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	1.02e-07	181	193	9	e47664a264a2c37390d1668ce04eef2e0172f4cb
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGLV11-55 IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 SPACA3	1.11e-07	183	193	9	5ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell	IPF-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	ZNF608 IGKV3D-20 IGKV3D-15 IGKV3D-11 C4A C4B IGKV3-20 IGKV3-15 IGKV3-11	1.28e-07	186	193	9	f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3B KIF26A INPP5D SHE DOCK6 ROBO4 HSPA4L FAM171A1 TLNRD1	1.68e-07	192	193	9	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	1.75e-07	193	193	9	34f6c13884fdf7f8a87f942fcb36a58cfac3f65d
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	1.83e-07	194	193	9	6ef4aeb8d8e35e4df58ff2a8256caa2113291de9
ToppCell	Biopsy_Other_PF-Immune-Plasma_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	IGLV11-55 IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	1.91e-07	195	193	9	d0305c6a68c9e361507b04db94f86873085d49b3
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	INPP5D FCHO1 C12orf42 IGKV3D-11 IGKV3-15 IGKV3-11 WDFY4 MAP4K1 ATP2A3	2.00e-07	196	193	9	fc67d8aad1ec4d7f98ffe44fb103e230b9b42c35
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGLV5-48 C12orf42 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	2.09e-07	197	193	9	9fe1b757f76c2d43d39aa9ac500eaba98723985c
ToppCell	367C-Lymphocytic-Plasma_cell-\|367C / Donor, Lineage, Cell class and subclass (all cells)	IGLV5-48 IGKV3D-20 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGHV3-49 ARSA	7.01e-07	167	193	8	f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell	367C-Lymphocytic-Plasma_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	IGLV5-48 IGKV3D-20 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGHV3-49 ARSA	7.01e-07	167	193	8	5e768cf24699893e05d1bcb1c92dba2336943a64
ToppCell	Control-Lymphoid-B_Plasma\|Control / Disease state, Lineage and Cell class	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	8.76e-07	172	193	8	61e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCell	COPD-Lymphoid-B_Plasma\|World / Disease state, Lineage and Cell class	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	9.98e-07	175	193	8	d73ee324479172501481b54967a0f3bd870fcf3a
ToppCell	Control-Lymphoid_P-Plasmablast\|Control / Disease group, lineage and cell class	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 SPACA3	1.04e-06	176	193	8	4b4416f342b732d2cc60133838728880326257d8
ToppCell	Control-Lymphoid_P\|Control / Disease group, lineage and cell class	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 SPACA3	1.04e-06	176	193	8	d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCell	IPF-Lymphoid-B_Plasma\|IPF / Disease state, Lineage and Cell class	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	1.04e-06	176	193	8	e4f33f6cd140dd4fa3002bcd65ac8005d27865d1
ToppCell	(2)_Plasma_cells\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	1.09e-06	177	193	8	ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B INPP5D ZNF831 CD6 MAP4K1 CD70 LINC02694 PIK3R5	1.45e-06	184	193	8	6119140287ab4b88e41194bf8d6f77ae264b3b98
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B INPP5D ZNF831 CD6 MAP4K1 CD70 LINC02694 PIK3R5	1.45e-06	184	193	8	6ce9aea2c1c9098f37bdf5135b5e2192ef03b50b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B INPP5D ZNF831 CD6 MAP4K1 CD70 LINC02694 PIK3R5	1.45e-06	184	193	8	895f7492d47c4782809bbb125c258127de04f888
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 SPACA3	1.51e-06	185	193	8	08bc817908076734d66f2805cb954141f2cc5a18
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 SPACA3	1.51e-06	185	193	8	1704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgA_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 SPACA3	1.58e-06	186	193	8	e2c050ba02e1f84f0b7258dc92e7ff6ab349ff67
ToppCell	healthy_donor-Lymphocytic-Plasma_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 SPACA3	1.71e-06	188	193	8	bd53b0371154cff680226897b61c9809a239d1b6
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	1.85e-06	190	193	8	79ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	1.85e-06	190	193	8	18762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCell	control-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PDE3B FBXL13 ITGAX DENND3 SLC45A4 ARHGEF40 IGF2R SLC15A4	1.92e-06	191	193	8	db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCell	Adult-Immune-T_lymphocyte-D175\|Adult / Lineage, Cell type, age group and donor	KRT72 INPP5D ZNF831 TRABD2A CD6 MAP4K1 LINC02694 ATP2A3	1.92e-06	191	193	8	0b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE3B INPP5D ZNF831 PASK AGAP2 TRABD2A CD6 PIK3R5	2.00e-06	192	193	8	92f141d5ac462f652f405efa73ac6ef751f40ea3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DISC1 INPP5D ITGAX FCHO1 C12orf42 WDFY4 MAP4K1 PIK3R5	2.08e-06	193	193	8	3e3d7cb3e7242ec9c9677e07e303835649852b52
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3B DISC1 MCC ZNF608 SHE DOCK6 ROBO4 FAM171A1	2.08e-06	193	193	8	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	2.08e-06	193	193	8	282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B INPP5D ZNF831 ITGAX TRABD2A CD6 ATP2A3 PIK3R5	2.16e-06	194	193	8	4dfc890bacf133cfb6ec7c8b73f084f2491cf78e
ToppCell	LPS_only-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3B MCC MAST4 ZNF608 SHE DOCK6 ROBO4 FAM171A1	2.16e-06	194	193	8	58f069efdefa0366033764446b9d6ffd4a17807e
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE3B MCC MAST4 ZNF608 SHE DOCK6 ROBO4 FAM171A1	2.16e-06	194	193	8	bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCell	COVID-19-lung-CD4+_T_cells_metabolically_active\|lung / Disease (COVID-19 only), tissue and cell type	PDE3B INPP5D ZNF831 CD6 MAP4K1 CD70 LINC02694 ATP2A3	2.16e-06	194	193	8	2a144a1c2d537c8a59aa419206ddd96c23f0aeab
ToppCell	Lung_Parenchyma-Control-Lymphocyte-B\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	INPP5D C12orf42 IGKV3D-20 IGKV3-20 IGKV3-11 CD70 ATP2A3 SPACA3	2.24e-06	195	193	8	c5ed36f649dc43c2811637890bbc5192981c7311
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B DISC1 INPP5D ZNF831 ITGAX WDFY4 CD6 PIK3R5	2.24e-06	195	193	8	7b6c69df943842b566a596e30bb50dbe80dccc83
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGHV3-49	2.24e-06	195	193	8	f3f7f1a77a1edd2b50a8211c76fe289738eb04cf
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_plasma\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	2.33e-06	196	193	8	c38e7f533c619afe008de0e99042f7180c2da918
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7	2.33e-06	196	193	8	fec21383435779bf4c632decd3d29c6ca7baebfb
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-B\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	C12orf42 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 MAP4K1 CD70	2.42e-06	197	193	8	88b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DISC1 INPP5D ZNF831 ITGAX WDFY4 CD6 ATP2A3 PIK3R5	2.42e-06	197	193	8	61ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD4\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3B INPP5D ZNF831 TRABD2A CD6 MAP4K1 LINC02694 PIK3R5	2.71e-06	200	193	8	d8459e45a8396a9ee063666a1928c649162c5727
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HIC1 PDE3B MAST4 ZNF608 DOCK6 ROBO4 CDC42EP1 FAM171A1	2.71e-06	200	193	8	f15fffefe372005c33e31845982e2d2714ac26af
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_TRM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3B INPP5D ZNF831 CD6 MAP4K1 LINC02694 ATP2A3 PIK3R5	2.71e-06	200	193	8	9ef322486e46e4ff05a8cbe06cf8019e996c94b3
ToppCell	metastatic_Lymph_Node-B_lymphocytes-Plasma_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	IGLV5-48 IGKV3D-20 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 IGHV3-49	2.92e-06	142	193	7	5ba3a33c2ee20be8baaed97536ca6e9d1de6752f
ToppCell	COVID-19_Severe-CD8+_T_naive\|COVID-19_Severe / disease group, cell group and cell class	KRT72 PDE3B PASK SYDE2 TRABD2A PPEF2 CD6	4.59e-06	152	193	7	e6dbf20504c4fb73d1084b587e040855335b8959
ToppCell	COVID-19_Severe-CD8+_T_naive\|World / disease group, cell group and cell class	KRT72 PDE3B PASK SYDE2 TRABD2A PPEF2 CD6	5.00e-06	154	193	7	b568417d88a78d8c46688847f0f5f4989bd36387
ToppCell	mild_COVID-19_(asymptomatic)-CD8+_T_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	PDE3B FBXL13 PASK SYDE2 TRABD2A LRFN1 CELSR2	5.22e-06	155	193	7	e2c901d5c9e42d25d7702e5e8fc19b06f7c817be
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TSPOAP1 ARMC2 ITGAX SULF1 PRDM10-DT MAMDC4	7.27e-06	107	193	6	410b37beffaf637a2a64c9d0ce7baf81f4bc667c
ToppCell	368C-Epithelial_cells-Epithelial-B_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TSPOAP1 ARMC2 ITGAX SULF1 PRDM10-DT MAMDC4	7.27e-06	107	193	6	5bae4b3aede9bcbf7e88414e3453973cc8b0c3e7
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCK C4A AP3D1 PPEF2 SRRM2 ATP2A3 ZNF445	8.18e-06	166	193	7	66026988509e39e41274fa0de738383219e8ff30
ToppCell	facs-GAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3B FCHO1 FREM3 CD6 RAB3IP FIBCD1 ATP2A3	8.18e-06	166	193	7	3695407e4638f3c18fbff63daba52baa9256c429
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SRARP SLC25A25 CALCA KIF26B ENTPD2 NEURL1 ESPL1	8.50e-06	167	193	7	49d9220f22d10ff06c0512c9c40c26ad51728e4f
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SRARP SLC25A25 CALCA KIF26B ENTPD2 NEURL1 ESPL1	8.50e-06	167	193	7	7ec032a98a13504d15c7e3a4e259278d07f40180
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SRARP SLC25A25 CALCA KIF26B ENTPD2 NEURL1 ESPL1	8.50e-06	167	193	7	5e3588eee73693a996bb4846427cf0038ceafbca
ToppCell	tumor_Lung-B_lymphocytes-Plasma_cells\|tumor_Lung / Location, Cell class and cell subclass	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3-20 IGKV3-15 IGKV3-11 ARSA	9.19e-06	169	193	7	b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INPP5D ADGRB3 ZNF831 MAST4 PPEF2 NEURL1 PIK3R5	9.55e-06	170	193	7	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGLV5-48 IGKV3D-15 IGKV3-20 IGKV3-15 IGKV3-7 IGHV3-49 SPACA3	9.92e-06	171	193	7	13126a3fbee181412c13ffb0c347277b9d8f16f7
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLV5-48 IGKV3D-20 IGKV3-20 IGKV3-15 IGKV3-11 IGKV3-7 IGHV3-49	1.07e-05	173	193	7	0ca2169a275404118038c0489a48062879488765
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	FCHO1 SULF1 A4GALT WT1 GRIN2A ENTPD2 LRRN4	1.07e-05	173	193	7	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	facs-Aorta-Heart-24m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGAX MTO1 GOT1 WDFY4 MAP4K1 ESPL1 PIK3R5	1.07e-05	173	193	7	d0d1c8bcef3d9c28ee9a7c64076624b836cb2580
ToppCell	metastatic_Brain-B_lymphocytes-MALT_B_cells\|metastatic_Brain / Location, Cell class and cell subclass	IGLV5-48 IGKV3D-20 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 ARSA	1.20e-05	176	193	7	50e207403d48ce1b55a78897adb5519a2430a626
ToppCell	VE-plasma\|VE / Condition, Cell_class and T cell subcluster	IGLV11-55 IGLV5-48 IGKV3D-15 IGKV3-20 IGKV3-11 IGHV3-49 SPACA3	1.24e-05	177	193	7	0c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCell	VE-plasma-\|VE / Condition, Cell_class and T cell subcluster	IGLV11-55 IGLV5-48 IGKV3D-15 IGKV3-20 IGKV3-11 IGHV3-49 SPACA3	1.24e-05	177	193	7	3a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	C12orf42 IGKV3D-20 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 CD70	1.29e-05	178	193	7	107dae8b00c4257697a63700e72bb434cdb8406f
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11 SPACA3	1.34e-05	179	193	7	494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCell	cellseq-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGLV5-48 C12orf42 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11	1.38e-05	180	193	7	cd04d7bf92986a5b8a0193c9b92ec47da3929bac
ToppCell	cellseq-Immune-Lymphocytic_B\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGLV5-48 C12orf42 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11	1.38e-05	180	193	7	663a800ab70e7ab7d13183417f9c1ed36907aa5e
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-cDC1\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGAX HESX1 INPP5F WDFY4 RFPL4AL1 RFPL4A MCUR1	1.54e-05	183	193	7	661bfc8f5f683b0f4c12bdd359e67c513b181678
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	ADGRB3 CACNA1H AGAP2 CDC42BPA SH3RF1 DENND3 GUCY1A1	1.54e-05	183	193	7	273db6a3b00a93ca852498471187b642b5368185
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DISC1 INPP5D ITGAX FCHO1 WDFY4 MAP4K1 PIK3R5	1.60e-05	184	193	7	4f4aeef3b821a003e857fe4a195124d44b2d7479
ToppCell	mild-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PDE3B ITGAX DENND3 SLC45A4 IGF2R SLC15A4 ENTPD2	1.60e-05	184	193	7	1a0e8b20b3ac8416d05c2d5934ab4ac80be4cce5
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11	1.65e-05	185	193	7	6ec009e48e50471c28e914c402f500e56a88f8f2
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	INPP5D CRACR2B ZNF831 SLC30A3 A4GALT SHE ROBO4	1.65e-05	185	193	7	fb84fcf7f51f53489bcb3962fa9cb483e48257ed
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGLV5-48 IGKV3D-20 IGKV3D-15 IGKV3D-11 IGKV3-20 IGKV3-15 IGKV3-11	1.65e-05	185	193	7	f49ad6401b2abd089e30eba245b11b5031ea2318
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	ADGRB3 CACNA1H DOCK6 AGAP2 SH3RF1 DENND3 GUCY1A1	1.65e-05	185	193	7	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	Control-T_cells-CD8+_T_cells\|Control / group, cell type (main and fine annotations)	PDE3B INPP5D ZNF831 C12orf42 LINC00612 CD6 PIK3R5	1.65e-05	185	193	7	02ab64c0166c0646d1d4c6ed110ef0b75a1096d0
ToppCell	15-Distal-Immune-Hematopoietic,_T_Cells\|Distal / Age, Tissue, Lineage and Cell class	ZNF831 FCHO1 AGAP2 CD6 MAP4K1 ATP2A3 PIK3R5	1.65e-05	185	193	7	481e3d3b63f2e5b4783088523c3cf70a461aed27
ToppCell	COPD-Lymphoid-B\|World / Disease state, Lineage and Cell class	INPP5D SREBF2 C12orf42 WDFY4 MAP4K1 CD70 ATP2A3	1.65e-05	185	193	7	22891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B INPP5D ZNF831 TRABD2A CD6 MAP4K1 PIK3R5	1.71e-05	186	193	7	9d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B INPP5D ZNF831 TRABD2A CD6 MAP4K1 PIK3R5	1.71e-05	186	193	7	bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	INPP5D CRACR2B ZNF831 SLC30A3 A4GALT SHE ROBO4	1.71e-05	186	193	7	9d250d5ae7cf9129be05b41d70cb6c3a046c5f1e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B DISC1 INPP5D ITGAX C12orf42 WDFY4 PIK3R5	1.71e-05	186	193	7	e152bdd837366e3e0b8bcfdb4d53f0685f2e803a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B INPP5D ZNF831 TRABD2A CD6 MAP4K1 PIK3R5	1.71e-05	186	193	7	924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	ADGRB3 CACNA1H AGAP2 CDC42BPA SH3RF1 DENND3 GUCY1A1	1.77e-05	187	193	7	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	MCC MAST4 SHE DOCK6 TRABD2A SLC45A4 FAM171A1	1.83e-05	188	193	7	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-B_lymphocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IGKV3D-20 IGKV3D-15 IGKV3D-11 C4B IGKV3-20 IGKV3-15 IGKV3-11	1.83e-05	188	193	7	c3cae529fdbeb233d2b32bcc3537a8aba26a7dc2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B DISC1 INPP5D ITGAX C12orf42 WDFY4 PIK3R5	1.83e-05	188	193	7	0d7296ad26e97ad91c6927a6cfe4e6e70a74c5a6
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|368C / Donor, Lineage, Cell class and subclass (all cells)	INPP5D PRR12 OXSM TRABD2A PPP1R3D FLVCR1-DT SLC15A4	1.90e-05	189	193	7	610d7cc1fc923dbd67d3b71f94d529a658982f87
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE3B INPP5D ZNF831 PASK TRABD2A CD6 PIK3R5	1.96e-05	190	193	7	2a8de1cf27a9ebc3825cf9e7a489ecd064dfc7f9
Disease	Autistic Disorder	DISC1 MCC PASK CACNA1H C4B ROBO4 CALCA GRIN2A WDFY4	3.17e-05	261	178	9	C0004352
Disease	choroideremia (implicated_via_orthology)	CHM CHML	3.62e-05	2	178	2	DOID:9821 (implicated_via_orthology)
Disease	complex cortical dysplasia with other brain malformations (is_implicated_in)	KIF26A APC2	2.15e-04	4	178	2	DOID:0090131 (is_implicated_in)
Disease	platelet crit	ANKRD31 HIC1 TNFSF12 KIF26A ZNF318 NDUFAB1 ITGAX MAST4 A4GALT PMS2P1 NYAP2 HEATR4 OSER1 SLC45A4 ARHGEF40 LINC02694	2.26e-04	952	178	16	EFO_0007985
Disease	triglycerides in LDL measurement	NYAP2 IGF2R CELSR2 PCCB	3.68e-04	56	178	4	EFO_0022320
Disease	free cholesterol to total lipids in medium VLDL percentage	ANKRD31 NYAP2 RGS12 CELSR2	3.94e-04	57	178	4	EFO_0022284
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	ANKRD31 DOCK6 NYAP2 USP24 IGF2R TENM4 CELSR2 PCCB	4.08e-04	291	178	8	EFO_0008317, EFO_0020946
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	ANKRD31 NYAP2 USP24 RGS12 IGF2R CELSR2 PCCB	4.17e-04	222	178	7	EFO_0008317, EFO_0020943
Disease	free cholesterol to total lipids in very large VLDL percentage	ANKRD31 NYAP2 RGS12 CELSR2	4.50e-04	59	178	4	EFO_0022289
Disease	phospholipids:total lipids ratio	ANKRD31 DOCK6 NYAP2 USP24 IGF2R CELSR2 PCCB	4.77e-04	227	178	7	EFO_0020946
Disease	total lipids in VLDL measurement	NYAP2 IGF2R CELSR2 PCCB	4.80e-04	60	178	4	EFO_0022314
Disease	triglycerides in medium LDL measurement	NYAP2 IGF2R CELSR2 PCCB	5.44e-04	62	178	4	EFO_0022322
Disease	triglycerides to total lipids in medium VLDL percentage	ANKRD31 NYAP2 RGS12 CELSR2	5.78e-04	63	178	4	EFO_0022335
Disease	cholesterol to total lipids in medium VLDL percentage	ANKRD31 NYAP2 RGS12 CELSR2	5.78e-04	63	178	4	EFO_0022239
Disease	cholesterol in large VLDL measurement	NYAP2 IGF2R CELSR2 PCCB	6.51e-04	65	178	4	EFO_0021902
Disease	cholesterol in very large VLDL measurement	NYAP2 IGF2R CELSR2 PCCB	6.51e-04	65	178	4	EFO_0022230
Disease	total lipids in small VLDL	ANKRD31 IGF2R CELSR2 PCCB	7.30e-04	67	178	4	EFO_0022148
Disease	free cholesterol in large VLDL measurement	ANKRD31 NYAP2 CELSR2 PCCB	7.72e-04	68	178	4	EFO_0022265
Disease	Lupus Erythematosus, Systemic	C4A C4B PHRF1 SLC15A4	9.08e-04	71	178	4	C0024141
Disease	waist circumference, sexual dimorphism	DACT2 NYAP2	9.89e-04	8	178	2	EFO_0004342, EFO_0005951
Disease	HMG CoA reductase inhibitor use measurement	DOCK6 NYAP2 RGS12 CELSR2 GUCY1A1 PCCB	1.04e-03	189	178	6	EFO_0009932
Disease	esterified cholesterol measurement	ANKRD31 DOCK6 NYAP2 IGF2R CELSR2	1.10e-03	128	178	5	EFO_0008589
Disease	myocardial infarction	ANKRD31 ZNF831 FCHO1 AP3D1 NYAP2 CELSR2 GUCY1A1 PCCB	1.35e-03	350	178	8	EFO_0000612
Disease	fatty acid measurement	ANKRD31 GCK GMIP DOCK6 NYAP2 RGS12 IGF2R CELSR2 PCCB	1.39e-03	436	178	9	EFO_0005110
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	GCK DOCK6 NYAP2 IGF2R TENM4 CELSR2 PCCB	1.43e-03	274	178	7	EFO_0004530, EFO_0004612
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	MOSPD3 NYAP2 USP24 IGF2R CELSR2	1.49e-03	137	178	5	EFO_0004611, EFO_0008591
Disease	valine measurement	ARMC2 NYAP2 PCCB	1.81e-03	40	178	3	EFO_0009792
Disease	systemic lupus erythematosus (implicated_via_orthology)	INPP5D C4A C4B	2.23e-03	43	178	3	DOID:9074 (implicated_via_orthology)
Disease	spleen volume	HIC1 NYAP2 LINC02694	2.23e-03	43	178	3	EFO_0600047
Disease	triglycerides in large LDL measurement	IGF2R CELSR2 PCCB	2.23e-03	43	178	3	EFO_0022319
Disease	sleep duration, low density lipoprotein cholesterol measurement	ANKRD31 USP24 IGF2R CELSR2	2.27e-03	91	178	4	EFO_0004611, EFO_0005271
Disease	low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	ANKRD31 DOCK6 NYAP2 IGF2R CELSR2	2.41e-03	153	178	5	EFO_0004611, EFO_0020944
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	GCK ARMC2 NYAP2 IGF2R CELSR2 PCCB	2.46e-03	224	178	6	EFO_0004530, EFO_0008317
Disease	fibrinogen measurement, coronary artery disease	FCHO1 IGF2R ARSA CELSR2 GUCY1A1	2.48e-03	154	178	5	EFO_0001645, EFO_0004623
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	ANKRD31 NYAP2 USP24 RGS12 IGF2R CELSR2	2.52e-03	225	178	6	EFO_0008317, EFO_0020947
Disease	optic disc area measurement	ASB7 CDC42BPA CDC42EP1	2.54e-03	45	178	3	EFO_0006937
Disease	cholesterol to total lipids in large VLDL percentage	ANKRD31 NYAP2 CELSR2	2.54e-03	45	178	3	EFO_0022236
Disease	smoking status measurement, systolic blood pressure	TNFSF12 ZNF318 ZNF831 TENM4 GUCY1A1	2.62e-03	156	178	5	EFO_0006335, EFO_0006527
Disease	selective IgA deficiency disease	FASN MAST4 FAM171A1	2.71e-03	46	178	3	EFO_1001929
Disease	birth weight	TNFSF12 NFILZ SREBF2 ARMC2 NYAP2 WT1 SLC45A4 TENM4	3.03e-03	399	178	8	EFO_0004344
Disease	nephroblastoma (is_implicated_in)	WT1 IGF2R	3.14e-03	14	178	2	DOID:2154 (is_implicated_in)
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	GCK NYAP2 IGF2R CELSR2 PCCB	3.42e-03	166	178	5	EFO_0004530, EFO_0004611
Disease	triglycerides to total lipids in medium LDL percentage	NYAP2 CELSR2 PCCB	3.44e-03	50	178	3	EFO_0022334
Disease	lysophosphatidylcholine 14:0 measurement	SLC30A3 ARMC2	3.61e-03	15	178	2	EFO_0010356
Disease	superior parietal cortex volume measurement	ADGRB3 SHC3	3.61e-03	15	178	2	EFO_0010330
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	ANKRD31 SLC30A3 CELSR2	3.63e-03	51	178	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	triglycerides to total lipids in large LDL percentage	NYAP2 CELSR2 PCCB	3.63e-03	51	178	3	EFO_0022331
Disease	cholesterol to total lipids in small VLDL percentage	ANKRD31 NYAP2 CELSR2	3.63e-03	51	178	3	EFO_0022242
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	DOCK6 NYAP2 RGS12 IGF2R CELSR2 PCCB	3.67e-03	243	178	6	EFO_0004612, EFO_0020944
Disease	triglycerides to total lipids in very large VLDL percentage	ANKRD31 NYAP2 CELSR2	4.05e-03	53	178	3	EFO_0022340
Disease	free cholesterol to total lipids in small LDL percentage	NYAP2 CELSR2 PCCB	4.05e-03	53	178	3	EFO_0022286
Disease	Agents acting on the renin-angiotensin system use measurement	ZNF318 ZNF831 NYAP2 RGS12 CELSR2 GUCY1A1 PCCB	4.37e-03	335	178	7	EFO_0009931
Disease	RS-10-hydroxywarfarin to RS-warfarin ratio measurement	ASB7 PHRF1 TENM4 CD70	4.50e-03	110	178	4	EFO_0803335
Disease	triglyceride measurement, intermediate density lipoprotein measurement	NYAP2 IGF2R CELSR2 PCCB	4.65e-03	111	178	4	EFO_0004530, EFO_0008595
Disease	response to statin	DISC1 ADGRB3 CELSR2	4.73e-03	56	178	3	GO_0036273
Disease	cholesteryl esters to total lipids in large VLDL percentage	ANKRD31 NYAP2 CELSR2	4.73e-03	56	178	3	EFO_0022250
Disease	cholesteryl ester measurement	ANKRD31 DOCK6 NYAP2 IGF2R CELSR2 PCCB	4.82e-03	257	178	6	EFO_0010351
Disease	factor VIII measurement, coronary artery disease	FCHO1 IGF2R CELSR2 GUCY1A1	4.95e-03	113	178	4	EFO_0001645, EFO_0004630
Disease	total lipids in large LDL	ANKRD31 IGF2R CELSR2	4.97e-03	57	178	3	EFO_0022163
Disease	cholesterol in large LDL measurement	ANKRD31 IGF2R CELSR2	4.97e-03	57	178	3	EFO_0021901
Disease	very low density lipoprotein cholesterol measurement	ANKRD31 NYAP2 RGS12 IGF2R CELSR2 PCCB	5.09e-03	260	178	6	EFO_0008317
Disease	total cholesterol measurement, low density lipoprotein cholesterol measurement	ANKRD31 MOSPD3 IGF2R CELSR2	5.10e-03	114	178	4	EFO_0004574, EFO_0004611
Disease	migraine disorder, systolic blood pressure	HIC1 ITGB5	5.20e-03	18	178	2	EFO_0006335, MONDO_0005277
Disease	level of Sphingomyelin (d34:1) in blood serum	BTC USP24	5.20e-03	18	178	2	OBA_2045175
Disease	triglycerides in IDL measurement	IGF2R CELSR2 PCCB	5.22e-03	58	178	3	EFO_0022149
Disease	triglycerides to total lipids in small VLDL percentage	ANKRD31 NYAP2 CELSR2	5.22e-03	58	178	3	EFO_0022338
Disease	factor XI measurement, coronary artery disease	FCHO1 IGF2R CELSR2 GUCY1A1	5.26e-03	115	178	4	EFO_0001645, EFO_0004694
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	ANKRD31 NYAP2 USP24 IGF2R CELSR2 PCCB	5.48e-03	264	178	6	EFO_0008317, EFO_0020944
Disease	triglycerides to total lipids in small LDL percentage	NYAP2 CELSR2 PCCB	5.48e-03	59	178	3	EFO_0022337
Disease	cholesterol in medium HDL measurement	DOCK6 NYAP2 CELSR2	5.48e-03	59	178	3	EFO_0021903
Disease	phospholipids in VLDL measurement	IGF2R CELSR2 PCCB	5.48e-03	59	178	3	EFO_0022301
Disease	linoleic acid measurement	MAST4 DOCK6 NYAP2 IGF2R CELSR2	5.52e-03	186	178	5	EFO_0006807
Disease	triglycerides to total lipids in large HDL percentage	NYAP2 RGS12 PCCB	5.74e-03	60	178	3	EFO_0022330
Disease	Congenital hernia of foramen of Morgagni	WT1 IGF2R	5.78e-03	19	178	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	WT1 IGF2R	5.78e-03	19	178	2	C0265700
Disease	free cholesterol in very large VLDL measurement	ANKRD31 NYAP2 PCCB	6.01e-03	61	178	3	EFO_0022274
Disease	free cholesterol in VLDL measurement	IGF2R CELSR2 PCCB	6.01e-03	61	178	3	EFO_0022276
Disease	phospholipids in HDL measurement	DOCK6 NYAP2 CELSR2	6.01e-03	61	178	3	EFO_0022293

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSAGALATALCSLPR	TTYH1	401	Q9H313
GTLSRGVSPCLTLAS	nan	136	Q6ZRM9
LSSTRPDEGLASIIC	NAIP	506	Q13075
AALRSPTLREAASSC	MAMDC4	126	Q6UXC1
TVLRLCDGSAAPASS	BRAT1	396	Q6PJG6
SPSTSCGSLTERLLR	AKAP9	3576	Q99996
ARLGEKICTRSSSSP	ATG13	31	O75143
RLSTCLLSAPSGIQR	ARHGEF40	161	Q8TER5
LAVSISISGSSRPCL	ASB7	251	Q9H672
TFVTPCLLAGDRSLA	RNPEP	306	Q9H4A4
GAPSKSRLLATLCSA	C4B	1571	P0C0L5
SLAESRACRGVTTLP	A4GALT	266	Q9NPC4
PCRAATITGTLSRIS	ADGRB3	1206	O60242
CLIATGGTPRSLSAI	AIFM1	256	O95831
ARASSCPSSSDLSRL	ARMC2	231	Q8NEN0
LTLSPRLECSGAISA	CCDC28A-AS1	56	A0A096LPI5
LAVARPLSTALCSAG	NDUFAB1	26	O14561
PLSTALCSAGTQTRL	NDUFAB1	31	O14561
RVKGPLLAACSSESR	AP4B1	276	Q9Y6B7
RNLARALSTDCTPSG	AGAP2	801	Q99490
SSLLRLPLEQCTGSS	CELSR2	2851	Q9HCU4
PRNSSLRLTDTAGCR	DENND3	486	A2RUS2
CGLDSRGLLVRSPVS	DISC1	86	Q9NRI5
GICSPASRSISLLRL	CD70	131	P32970
SDTLRCLALATRDAP	ATP2A3	556	Q93084
EVFCSVPGRLSLLSS	TFAP2E	216	Q6VUC0
ALTGLSCFVTPDLAR	AP3D1	131	O14617
TGLPESIIAAACSRS	CHM	16	P24386
TGLPESILAAACSRS	CHML	16	P26374
GALLSALSRSVRACP	RASA4	421	O43374
SLSGSHSCLLRPRSL	NFILZ	131	A0A5F9ZHS7
GALLSALSRSVRACP	RASA4B	421	C9J798
SSPRRLNCAEISSIS	RAB3IP	86	Q96QF0
ALTSRGSSDPLRCCL	TSPOAP1	861	O95153
LRSLHLTCDSAPVGS	ITGAX	841	P20702
ILSTLGLRPSTTDCD	GCK	351	P35557
LSLSPGERATLSCRA	IGKV3D-11	31	A0A0A0MRZ8
ERLPVRLTNGSSSCS	CD6	41	P30203
CEPSSLTLSSLRNGL	ANKRD31	781	Q8N7Z5
TDSCISPLSLAGFSR	OXSM	236	Q9NWU1
LRCSAPSSEGACSLV	PCDHA7	721	Q9UN72
SCLDLSSGVAPRLSR	RSPH10B	351	P0C881
SCLDLSSGVAPRLSR	RSPH10B2	351	B2RC85
CPLTRSNGDLSRSLS	FCHO1	571	O14526
PRGSVSCCSLLRGLS	PASK	101	Q96RG2
SALRCLLEGSSRRSG	FAM171A1	811	Q5VUB5
SRCQTPSFLSRSRGL	KRT40	41	Q6A162
PSFLSRSRGLTGCLL	KRT40	46	Q6A162
PCSTRGLLSSGEVRF	LEXM	141	Q3ZCV2
PGGSETSARRCLSAL	MCUR1	31	Q96AQ8
TSARRCLSALSDGLG	MCUR1	36	Q96AQ8
PALVSCRRELSLSAG	MCUR1	131	Q96AQ8
RLLCPSLLAGTADGS	M1AP	266	Q8TC57
LSLSPGERATLSCGA	IGKV3D-20	31	A0A0C4DH25
VPVCRGRSFTALRSS	MCM8	266	Q9UJA3
RAASAIPVTCLLDSG	GMIP	726	Q9P107
ASERRCSPLCGLDLS	HIC1	231	Q14526
AATAAARCGSRTLLL	MTO1	51	Q9Y2Z2
RSLGGSATSLCLLPS	LRFN1	641	Q9P244
DCSARALASGSRPVS	KIF26B	1216	Q2KJY2
LSGSSDPHLCRDLVS	ENTPD2	301	Q9Y5L3
TARLPCTLSSDLSVG	IGLV11-55	36	A0A075B6I3
DRESLCGASTSCLLP	PCDHGC5	91	Q9Y5F6
PRRRSSCVSLGETAA	PDE3B	291	Q13370
SRDTGLPGCQSSLLR	TCF12	121	Q99081
RLCALRPDDSSSART	HEATR6	36	Q6AI08
PSTCSFSIERILGLD	HESX1	16	Q9UBX0
IPSACISRLTGREGT	PHRF1	706	Q9P1Y6
TLLKTCARARATAPG	LAPTM4B	76	Q86VI4
PQALRCGSTRRCSSL	FAM161B	121	Q96MY7
RNSRPSVVSLLRGSC	FLVCR1-DT	71	Q8TAF5
CSLRALASGSRPVSI	KIF26A	1061	Q9ULI4
LSVSPGERATLSCRA	IGKV3D-15	31	A0A087WSY6
VSLCTPSRAALLTGR	ARSA	66	P15289
TALCVLGTPRFTSGR	RFPL4A	136	A6NLU0
AVRCALIGPGSLTSR	PMS2P1	126	A4D2B8
CRATVRGLATFPATA	EPHA10	211	Q5JZY3
SRLGRCSVSPTLLAG	NYAP2	591	Q9P242
ISLRLRCSSRPATEG	PCDHGB3	711	Q9Y5G1
VQPGRSLRLSCTASG	IGHV3-49	31	A0A0A0MS15
SPRSITSRCDLRANL	ITGB5	56	P18084
ANSLGPSDRTLVLCS	MEIOSIN	16	C9JSJ3
ADPRTCLSLLSLGTC	IKBIP	41	Q70UQ0
VQTGSSSPCLDLSRL	PANK4	691	Q9NVE7
VLASGLRAAVRSLCS	PCCB	16	P05166
REVLASSTCGRPATR	NTN3	51	O00634
SPRSLSLIANLSGCT	PXDNL	696	A1KZ92
SLIANLSGCTARRPL	PXDNL	701	A1KZ92
SPSLAELLNRISGTC	CCNYL3	321	P0C7X3
PLVLSRCSSVSSLGS	APC2	1156	O95996
ASPALSLAELRTTCS	MCC	701	P23508
RGSSSGLLSPQRALC	ESPL1	236	Q14674
CLPRERLTTATAALS	IGSF10	1066	Q6WRI0
RRALPGCTSLTGETT	BRME1	381	Q0VDD7
LSGLTSDPRELCSCL	BABAM1	156	Q9NWV8
STVEISARARLASCP	DACT2	611	Q5SW24
SRRCSSSLGVPLTEV	DOCK6	36	Q96HP0
ALCSRPLRAALDTLG	C6orf47	196	O95873
GSSCRKALTTARLPG	CRACR2B	361	Q8N4Y2
TCATAALERPRIATS	HEATR4	501	Q86WZ0
LDSGFCTISRLPRSE	CDC42EP1	156	Q00587
KRLTARSISTPTCLG	CBX4	426	O00257
RSCASRLALGDDSPA	GOT1	81	P17174
CKGITDSSLRSLSPL	FBXL13	436	Q8NEE6
SSLARACPEGALSRV	FAM43A	36	Q8N2R8
SLSGSLLSECSNRPV	HASPIN	411	Q8TF76
ELSLPRRGSFCRTSN	MAST4	216	O15021
ATGSRPRDCLDVLLS	FIBCD1	236	Q8N539
DLSLAPRISGTVCLS	KHDC1	201	Q4VXA5
ASCVSLLCRPASSRL	KRTAP10-11	271	P60412
LSLSPGERATLSCRA	IGKV3-11	31	P04433
LSVSPGERATLSCRA	IGKV3-15	31	P01624
LSLSPGERATLSCRA	IGKV3-20	31	P01619
LSLSPGERVTLSCRA	IGKV3-7	31	A0A075B6H7
RGPSIALDTACSSSL	FASN	151	P49327
RCSGASSLPLLLALA	BTC	6	P35070
GGSTTLRRRTPSCEA	CACNA1H	2211	O95180
PATRAALCGSARLLN	SLC15A4	126	Q8N697
SCGIIASAPRLGSRS	INPP5F	891	Q9Y2H2
PRRLVSCLSSQSSAL	SPACA3	26	Q8IXA5
DDAGSSLLRGRCRSL	PRRT3	861	Q5FWE3
PRTGRLVSLSACGRT	NEURL4	46	Q96JN8
GAPSKSRLLATLCSA	C4A	1571	P0C0L4
GCLPRTLRSLDASHN	LRRN4	71	Q8WUT4
RSSSIPCSGSLDGRE	PPEF2	371	O14830
LEFLERCSSPLTRSS	PHF20L1	591	A8MW92
ASPGASARLTCTLRS	IGLV5-48	31	A0A075B6I7
TFRLLGSPRLECSGT	MAP4K1	791	Q92918
CLLLSRPALQGRASS	FREM3	21	P0C091
PLGCSERASICRRTT	IGF2R	2036	P11717
PSCSRSLESLRVGAK	SYDE2	81	Q5VT97
TALCVLGTPRFTSGR	RFPL4AL1	136	F8VTS6
RLESECSCGSSSPLR	SRRM3	186	A6NNA2
ARATLPLCRGSVASA	SRARP	106	Q8NEQ6
SRLSLRRSLSGSSPC	SRRM2	771	Q9UQ35
FSRSALSICASPRAG	TMEM151B	446	Q8IW70
RCESLLGLDPATGSR	LINC00869	121	P0C866
SSPILDLSESGLCRL	LRRC27	46	Q9C0I9
RAGARLSGSCSAPSL	SHC3	91	Q92529
PRLRSFTCSSSAEGR	INPP5D	1081	Q92835
ATAALRPAACGRTSL	PRDX3	26	P30048
LLSSGLRLCASARGS	OXCT1	6	P55809
CSLSPGTTVRDLIGR	NPRL2	286	Q8WTW4
SSCRSRPALSPLGDI	PRR12	1126	Q9ULL5
SDRSCLRVTAGPTSL	CDC42BPA	411	Q5VT25
LHARTLSGSPRSCSE	OSER1	241	Q9NX31
RGFRVLASCLTPSGA	RDH5	51	Q92781
SDSLCSRRGLSSPRL	ROBO4	621	Q8WZ75
ARISELSGLSCSAPS	SH3RF1	341	Q7Z6J0
CTSRSSGDTLPRLNR	SESTD1	571	Q86VW0
LRPAAGSFAAVCSRS	HIBADH	21	P31937
SLDSPRSKRCGNLST	CALCA	76	P01258
SRSCSAAAARPSLLQ	LINC00612	166	Q8N6U2
GSAARPSTAIGLCRR	C12orf42	211	Q96LP6
GCSREASPSRLSVAR	CLASP2	501	O75122
LRATPNTRGSARLLC	C15orf40	11	Q8WUR7
TRRRACQSLLSDPLG	LINC02694	156	Q8NAA6
LASARPATDCLRSGL	PRDM10-DT	96	Q96N53
NLSCRRASDSLSARP	ATP11C	1101	Q8NB49
FTPLIGSASDRCTLS	SLC45A4	101	Q5BKX6
AGAVSRTCTAPLDRL	SLC25A25	196	Q6KCM7
GLGLSPDLIVCRSST	CTPS2	206	Q9NRF8
TSAETSGGLLICLPR	SEPHS2	366	Q99611
LLALTSSDLGCQPSR	TMEM192	256	Q8IY95
RLDPAGSCSRSLASR	ZC3H3	636	Q8IXZ2
GLLARCGSRQLPSSV	nan	96	Q8N377
AGSLDLSEACRTLAP	RGS12	941	O14924
CPTRTGLLATLTRDS	MIOS	276	Q9NXC5
SALGSRLSDPLLSTC	NEURL1	471	O76050
SSDTALPLRRAGSLC	PIK3R5	446	Q8WYR1
NLSGAGISCRSTRDL	SAGE1	701	Q9NXZ1
SDRCTPACISLGSRT	HSPA4L	31	O95757
TASLLCSAADLPARG	SPPL2B	71	Q8TCT7
RALPTSRLDLACSLS	SREBF2	606	Q12772
TGTALRFRVLCTAPA	MOSPD3	61	O75425
LASPSLRTRFRDGLC	WDFY4	1651	Q6ZS81
TDSCTGSQALLLRTP	WT1	206	P19544
SRKLGPRSLSCLSDL	PPP1R3D	16	O95685
LLGSNDLTSARPLSC	TENM4	1381	Q6N022
GCTLLSQALRERSSP	TLNRD1	336	Q9H1K6
TLCLLPTGAASRRGA	TRABD2A	11	Q86V40
GRLASACSHSILRPS	MRPL21	11	Q7Z2W9
CALGSTAPTLRDVLR	SLC30A3	276	Q99726
SSGPLETLSRLRELC	ZNF445	66	P59923
LCPAGIRNRLSSSGS	USP24	1361	Q9UPU5
PSIGSASRLECSTLV	ZNF608	896	Q9ULD9
SATAASSLGPQLRLC	TNFSF12	196	O43508
RLGCRSGLSSTDVPS	ZNF831	541	Q5JPB2
TALCAAAALRGPRAS	TMEM70	21	Q9BUB7
RELLRLAVSCASGSP	TIGD5	431	Q53EQ6
ASSLACSTAPTLLGR	SHE	16	Q5VZ18
CRSPSLGSDLTFATR	SNTB2	391	Q13425
LSALLCRNSSLGSPS	UNK	366	Q9C0B0
ELLGSLCSTVRSPRF	SULF1	16	Q8IWU6
GSRRRSPGLCSDSLE	ZNF318	131	Q5VUA4
AALGCPARTLRVLSA	XRCC3	306	O43542
SRTCSRILGLSLGTA	TM4SF19	11	Q96DZ7
SSAILFLGSPCVDRL	GUCY1A1	376	Q02108
CLGGSRSLALSAAAR	KRT72	51	Q14CN4
RSSVGSPLRLCCRDL	LRRC14	186	Q15048
LLSSSLTADCSLRSP	NAA30	186	Q147X3
LTADCSLRSPSGREV	NAA30	191	Q147X3
GVCSDRPGLLFSISR	GRIN2A	851	Q12879