Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24	3.51e-10	37	155	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24	4.41e-10	38	155	8	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8	1.10e-06	11	155	4	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8	3.29e-06	14	155	4	GO:0003964
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 DICER1 ERVK-8	9.42e-06	37	155	5	GO:0016891
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-7 ERVK-10 DICER1 LACTB2 EXD2 ERVK-8 CNOT1	1.12e-05	136	155	8	GO:0004540
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-10 ERVK-8	1.89e-05	21	155	4	GO:0035613
GeneOntologyMolecularFunction	ATP-dependent activity	LONP2 MYO9A TWNK MSH2 DICER1 ABCA8 MYO5C MMAA ACSL1 AFG3L2 ABCG2 KIFC3 DNAH8 SMC1B ATP5F1B CDK7	2.40e-05	614	155	16	GO:0140657
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 DICER1 ERVK-8	2.80e-05	46	155	5	GO:0016893
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-7 ERVK-10 DICER1 LACTB2 ERVK-8	3.46e-05	79	155	6	GO:0004521
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	EEFSEC LONP2 LRRK2 TWNK MSH2 ABCA8 GSPT1 RHOA MMAA RHOC GSPT2 AFG3L2 ABCG2 DNAH8 SMC1B DNM2 ATP5F1B	1.13e-04	775	155	17	GO:0017111
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 CYP2C19 MATR3 ERVK-7 ERVK-21 ERVK-9 ERVK-10 LCN1 SF1 PIAS4 CUTC LACTB2 EXD2 AFG3L2 ERVK-8 ERVK-5 CYP7B1 ERVK-19 SMPD1 EEA1 DMD ERVK-24	1.31e-04	1189	155	22	GO:0046914
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 LONP2 ADAM7 ERVK-7 ERVK-21 ERVK-9 ERVK-10 THOP1 AFG3L2 ERVK-8 ERVK-19 ERVK-24	1.38e-04	430	155	12	GO:0004175
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ERVK-6 PALD1 PDE6B ERVK-7 ERVK-10 INPP5F UBLCP1 DICER1 PPP1CC LACTB2 EXD2 PAFAH1B2 ERVK-8 SMPD1 PNPLA7 CNOT1 RPAP2	1.82e-04	807	155	17	GO:0016788
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 MATR3 ERVK-7 ERVK-21 ERVK-9 ERVK-10 LCN1 SF1 PIAS4 LACTB2 AFG3L2 ERVK-8 ERVK-5 ERVK-19 SMPD1 EEA1 DMD ERVK-24	1.96e-04	891	155	18	GO:0008270
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8	2.10e-04	38	155	4	GO:0034061
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 TWNK MSH2 ERVK-7 ERVK-10 DICER1 EXD2 ERVK-8 CDK7	2.14e-04	262	155	9	GO:0140097
GeneOntologyMolecularFunction	pyrophosphatase activity	EEFSEC LONP2 LRRK2 TWNK MSH2 ABCA8 GSPT1 RHOA MMAA RHOC GSPT2 AFG3L2 ABCG2 DNAH8 SMC1B DNM2 ATP5F1B	2.87e-04	839	155	17	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	EEFSEC LONP2 LRRK2 TWNK MSH2 ABCA8 GSPT1 RHOA MMAA RHOC GSPT2 AFG3L2 ABCG2 DNAH8 SMC1B DNM2 ATP5F1B	2.91e-04	840	155	17	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	EEFSEC LONP2 LRRK2 TWNK MSH2 ABCA8 GSPT1 RHOA MMAA RHOC GSPT2 AFG3L2 ABCG2 DNAH8 SMC1B DNM2 ATP5F1B	2.91e-04	840	155	17	GO:0016818
GeneOntologyMolecularFunction	lamin binding	PPP1CC PKP1 DMD	4.06e-04	19	155	3	GO:0005521
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ERVK-7 ERVK-10 DICER1 LACTB2 EXD2 ERVK-8 CNOT1	4.55e-04	231	155	8	GO:0004518
GeneOntologyMolecularFunction	short-chain fatty acid transmembrane transporter activity	SLC22A25 SLC22A9	5.90e-04	5	155	2	GO:0015636
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-7 ERVK-10 DICER1 LACTB2 ERVK-8	6.81e-04	136	155	6	GO:0004519
GeneOntologyMolecularFunction	ubiquitin-modified histone reader activity	UIMC1 CCDC38	1.23e-03	7	155	2	GO:0061649
GeneOntologyMolecularFunction	translation termination factor activity	GSPT1 GSPT2	1.23e-03	7	155	2	GO:0008079
GeneOntologyMolecularFunction	translation release factor activity	GSPT1 GSPT2	1.23e-03	7	155	2	GO:0003747
GeneOntologyMolecularFunction	GTPase activator activity	ARHGAP42 MYO9A LRRK2 OPHN1 GRTP1 RAPGEF2 ARHGAP8 MTSS2	1.54e-03	279	155	8	GO:0005096
GeneOntologyMolecularFunction	ATP-dependent peptidase activity	LONP2 AFG3L2	1.63e-03	8	155	2	GO:0004176
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 LONP2 ADAM7 ERVK-7 ERVK-21 ERVK-9 ERVK-10 THOP1 DPEP2 AFG3L2 ERVK-8 ERVK-19 ERVK-24	1.80e-03	654	155	13	GO:0008233
GeneOntologyMolecularFunction	guanyl ribonucleotide binding	EEFSEC LRRK2 GSPT1 RHOA MMAA RANBP17 RHOC GSPT2 RAPGEF2 DNM2	2.31e-03	439	155	10	GO:0032561
GeneOntologyMolecularFunction	guanyl nucleotide binding	EEFSEC LRRK2 GSPT1 RHOA MMAA RANBP17 RHOC GSPT2 RAPGEF2 DNM2	2.31e-03	439	155	10	GO:0019001
GeneOntologyMolecularFunction	ATP hydrolysis activity	LONP2 TWNK MSH2 ABCA8 MMAA AFG3L2 ABCG2 DNAH8 SMC1B ATP5F1B	2.38e-03	441	155	10	GO:0016887
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10 ERVK-8	2.08e-06	13	155	4	GO:0015074
GeneOntologyBiologicalProcess	viral process	ERVK-6 ITCH HS3ST5 ERVK-7 ERVK-21 ERVK-9 ERVK-10 DICER1 ITGB6 ERVK-8 ERVK-5 ERVK-19 SMPD1 ERVK-24	1.13e-05	464	155	14	GO:0016032
Domain	P-loop_NTPase	EEFSEC LONP2 MYO9A LRRK2 HS3ST5 TWNK MSH2 DICER1 ABCA8 AK7 GSPT1 MYO5C RHOA MMAA RHOC GSPT2 AFG3L2 ABCG2 KIFC3 DNAH8 SMC1B MPP7 DNM2 ATP5F1B	5.52e-08	848	148	24	IPR027417
Domain	-	EEFSEC LONP2 LRRK2 HS3ST5 TWNK MSH2 DICER1 ABCA8 AK7 GSPT1 RHOA MMAA RHOC GSPT2 AFG3L2 ABCG2 DNAH8 SMC1B MPP7 DNM2 ATP5F1B	4.49e-07	746	148	21	3.40.50.300
Domain	G_TR_1	EEFSEC GSPT1 GSPT2	1.32e-04	13	148	3	PS00301
Domain	I-BAR_dom	ARHGAP42 OPHN1 MTSS2	1.32e-04	13	148	3	IPR013606
Domain	AAA	LONP2 ABCA8 MMAA AFG3L2 ABCG2 DNAH8 ATP5F1B	1.51e-04	144	148	7	SM00382
Domain	AAA+_ATPase	LONP2 ABCA8 MMAA AFG3L2 ABCG2 DNAH8 ATP5F1B	1.51e-04	144	148	7	IPR003593
Domain	MITF_TFEB_C_3_N	TFE3 MITF	1.86e-04	3	148	2	PF15951
Domain	MiT/TFE_N	TFE3 MITF	1.86e-04	3	148	2	IPR031867
Domain	EFTu-like_2	EEFSEC GSPT1 GSPT2	3.65e-04	18	148	3	IPR004161
Domain	GTP_EFTU_D2	EEFSEC GSPT1 GSPT2	3.65e-04	18	148	3	PF03144
Domain	G_TR_2	EEFSEC GSPT1 GSPT2	3.65e-04	18	148	3	PS51722
Domain	DUF3371	TFE3 MITF	3.70e-04	4	148	2	PF11851
Domain	MiT/TFE_C	TFE3 MITF	3.70e-04	4	148	2	IPR021802
Domain	-	LRRK2 PSMD1 RANBP17 UNC45B PKP1 IPO13 TAF6 SYMPK	3.98e-04	222	148	8	1.25.10.10
Domain	TF_GTP-bd_dom	EEFSEC GSPT1 GSPT2	4.30e-04	19	148	3	IPR000795
Domain	zf-CCHC	ERVK-6 SF1 ERVK-5	7.69e-04	23	148	3	PF00098
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	4.10e-10	4	158	4	10469592
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10 ERVK-5 ERVK-19	4.10e-10	4	158	4	7983737
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-5 ERVK-19 ERVK-24	5.01e-10	94	158	9	21542922
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19	1.40e-09	12	158	5	14557543
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7 ERVK-21 ERVK-19	2.04e-09	5	158	4	12629516
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	FLNB ITCH GOPC DSG2 MAT2A VPS33A DIDO1 SHOC2 UBLCP1 PPP1CC RHOA THOP1 AFAP1 AFG3L2 SORBS3 TTC17 TTC13 EEA1 MAP2K1 CNOT1 DNM2 CDK7	1.13e-07	1297	158	22	33545068
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLNB ITCH DSG2 MATR3 DIDO1 ACSL1 GSPT2 PAFAH1B2 EEA1 DNM2 CPSF7	8.70e-07	360	158	11	33111431
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7 ERVK-5	9.14e-07	5	158	3	11401426
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATMIN FLNB ITCH MYO9A PSMD1 SUCLA2 CASC2 UBLCP1 DENND2B PCDHB16 PIAS4 RANBP17 THOP1 GTF2I GRTP1 PCNX4 TTC17 PNPLA7 RAPGEF2 ARHGAP8 CNOT1 RPAP2	1.15e-06	1489	158	22	28611215
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	1.19e-06	18	158	4	18664271
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-9 ERVK-19	1.82e-06	6	158	3	15063128
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	DIDO1 SF1 GSPT1 GTF2I ZNF281 CPSF7 SYMPK	2.31e-06	130	158	7	35545047
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FLNB GOPC DSG2 MAT2A MATR3 PSMD1 MSH2 DICER1 ACSL1 THOP1 GTF2I AFG3L2 TTC17 TTC13 DMD MPP7 ATP5F1B	2.38e-06	974	158	17	28675297
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EEFSEC GOPC MAT2A DIDO1 MSH2 COPS3 PRPF18 SF1 GSPT1 RHOA ACSL1 GTF2I TAF6 ZNF281 CNOT1 DNM2 CPSF7 CDK7	3.02e-06	1103	158	18	34189442
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	UIMC1 FLNB ITCH LONP2 TAF1B PSMD1 RRP8 MSH2 COPS3 SUCLA2 DICER1 GTF2I AFG3L2 PKP1 CNOT1 MPP7 RPAP2	3.61e-06	1005	158	17	19615732
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	FLNB MATR3 MSH2 SHOC2 PPP1CC GTF2I CNOT1 SYMPK	4.47e-06	203	158	8	22083510
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEFSEC UIMC1 DSG2 LONP2 PCDHB7 DIDO1 TWNK RRP8 DICER1 PPP1CC TAOK2 RHOA AFAP1 RRP9 EXD2 AFG3L2 TAF6 ZNF281 MPP7 ATP5F1B CDK7	4.61e-06	1497	158	21	31527615
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNB DSG2 MATR3 HAUS5 PSMD1 MSH2 DICER1 SF1 MYO5C RRP9 EXD2 AFG3L2 PKP1 EEA1 CNOT1 ATP5F1B CPSF7	4.62e-06	1024	158	17	24711643
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FLNB ITCH DSG2 MAT2A MATR3 DIDO1 RRP8 MSH2 LRCH1 SF1 PPP1CC AFAP1 GTF2I RRP9 AFG3L2 PKP1 ATP5F1B CPSF7 CDK7	4.77e-06	1257	158	19	36526897
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	MYO9A LRRK2 MSH2 SF1 MYO5C AFG3L2 CNOT1 ATP5F1B	5.34e-06	208	158	8	33230847
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MATR3 HAUS5 DIDO1 INPP5F SHOC2 LRCH1 DICER1 GGA3 TAOK2 AFAP1 IPO13 CNOT1	5.99e-06	529	158	12	14621295
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	UIMC1 LCN1 PRPF18 SF1 PIAS4 GTF2I MITF TAF6 ZNF281 SYMPK CDK7	6.50e-06	444	158	11	34795231
Pubmed	Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.	MYO9A OPHN1 RHOA	7.57e-06	9	158	3	22891260
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FLNB DSG2 MAT2A PSMD1 MSH2 GSPT1 PPP1CC GTF2I CNOT1 DNM2 ATP5F1B CPSF7 SYMPK	7.70e-06	638	158	13	33239621
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNB DSG2 MAT2A MATR3 PSMD1 MSH2 COPS3 SUCLA2 CCDC38 DICER1 SF1 GSPT1 RHOA GTF2I RRP9 PKP1 EEA1 CNOT1 ATP5F1B CPSF7	7.88e-06	1425	158	20	30948266
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	ITCH LONP2 MATR3 DIDO1 LCN1 RAPGEF2 CPSF7 SYMPK	8.05e-06	220	158	8	24550385
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-21 ERVK-19	1.08e-05	10	158	3	12970426
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ITCH MAT2A MATR3 PSMD1 MSH2 SF1 GSPT1 PPP1CC RHOA THOP1 GSPT2 AFG3L2 MAP2K1 ZNF281 DNM2 ATP5F1B CPSF7 RPAP2	1.60e-05	1247	158	18	27684187
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	GPR155 FLNB COL6A3 UFC1 LRRK2 IRF6 VPS36 SUCLA2 RHOA RHOC BPI PAFAH1B2 KIFC3 EEA1 DNM2 ATP5F1B	1.71e-05	1016	158	16	19056867
Pubmed	Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling.	MYO9A RHOA	2.05e-05	2	158	2	23870313
Pubmed	RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts.	RHOA RHOC	2.05e-05	2	158	2	21454503
Pubmed	Activation of a bacterial virulence protein by the GTPase RhoA.	RHOA RHOC	2.05e-05	2	158	2	19887681
Pubmed	Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.	GSPT1 GSPT2	2.05e-05	2	158	2	15987998
Pubmed	CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma.	MITF CDK7	2.05e-05	2	158	2	34296805
Pubmed	Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.	RHOA RHOC	2.05e-05	2	158	2	12808121
Pubmed	Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation.	OPHN1 RHOA	2.05e-05	2	158	2	19401298
Pubmed	The identification and functional characterization of a novel mast cell isoform of the microphthalmia-associated transcription factor.	TFE3 MITF	2.05e-05	2	158	2	12039954
Pubmed	Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation.	PDE6B MITF	2.05e-05	2	158	2	11520113
Pubmed	Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.	TFE3 MITF	2.05e-05	2	158	2	16766266
Pubmed	Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers.	RHOA RHOC	2.05e-05	2	158	2	20503409
Pubmed	Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.	RHOA RHOC	2.05e-05	2	158	2	7989340
Pubmed	Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.	RHOA RHOC	2.05e-05	2	158	2	33825439
Pubmed	Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo.	RHOA RHOC	2.05e-05	2	158	2	20828398
Pubmed	Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells.	DICER1 ABCG2	2.05e-05	2	158	2	21878538
Pubmed	Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.	RHOA RHOC	2.05e-05	2	158	2	15668138
Pubmed	Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma.	RHOA RHOC	2.05e-05	2	158	2	17896152
Pubmed	Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning artifacts.	RHOA RHOC	2.05e-05	2	158	2	7835413
Pubmed	The developmental transcription factor IRF6 attenuates ABCG2 gene expression and distinctively reverses stemness phenotype in nasopharyngeal carcinoma.	IRF6 ABCG2	2.05e-05	2	158	2	29111349
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.05e-05	2	158	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.05e-05	2	158	2	9460924
Pubmed	The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.	ARHGAP42 RHOA	2.05e-05	2	158	2	24335996
Pubmed	ABCs of RhoGTPases indicating potential role as oncotargets.	RHOA RHOC	2.05e-05	2	158	2	28508825
Pubmed	Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters.	RHOA RHOC	2.05e-05	2	158	2	19499974
Pubmed	Frequency and impact of DHODH, ABCG2 and CYP2C19 SNPs on the therapeutic efficacy, tolerability and toxicity of leflunomide.	CYP2C19 ABCG2	2.05e-05	2	158	2	34747629
Pubmed	Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum.	EEFSEC MSH2	2.05e-05	2	158	2	11890935
Pubmed	Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton.	GSPT1 GSPT2	2.05e-05	2	158	2	24981173
Pubmed	Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.	RHOA RHOC	2.05e-05	2	158	2	21208644
Pubmed	Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity.	RHOA RHOC	2.05e-05	2	158	2	19642867
Pubmed	RhoA mediates defective stem cell function and heterotopic ossification in dystrophic muscle of mice.	RHOA DMD	2.05e-05	2	158	2	23704088
Pubmed	Lineage-specific transcriptional regulation of DICER by MITF in melanocytes.	DICER1 MITF	2.05e-05	2	158	2	20550935
Pubmed	Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle.	ITGB6 DMD	2.05e-05	2	158	2	24488487
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	UIMC1 FLNB DIDO1 MSH2 PPP1CC PIAS4 GTF2I CPSF7 SYMPK	2.28e-05	332	158	9	32786267
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	UIMC1 MATR3 DIDO1 RRP8 MSH2 SF1 TFE3 PPP1CC GTF2I TINF2 RRP9 AFG3L2 MITF TAF6 ZNF281 ATP5F1B CPSF7 SYMPK	2.60e-05	1294	158	18	30804502
Pubmed	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.	PDE6B DICER1 MITF	3.23e-05	14	158	3	21297615
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNB PSMD1 DIDO1 RRP8 MSH2 DICER1 PPP1CC GTF2I RRP9 CNOT1 DNM2 SYMPK	4.74e-05	653	158	12	22586326
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	PDE6B MATR3 FIS1 SUCLA2 SF1 PPP1CC RHOA PAFAH1B2 DMD ATP5F1B CPSF7	4.81e-05	552	158	11	36293380
Pubmed	A unique role of cohesin-SA1 in gene regulation and development.	PCDHB16 PCDH7 SMC1B	4.93e-05	16	158	3	22415368
Pubmed	Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.	SLC22A25 SLC22A9 ABCG2	4.93e-05	16	158	3	19679677
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	MYO9A MSH2 SHOC2 MYO5C GTF2I IPO13 ZNF281	5.38e-05	211	158	7	17314511
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	EEFSEC DSG2 TAF1B MATR3 DIDO1 RRP8 SUCLA2 DICER1 SF1 PPP1CC TAOK2 CUTC RHOC GTF2I EEA1 CNOT1 ATP5F1B CPSF7	5.50e-05	1371	158	18	36244648
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	UFC1 DIDO1 MSH2 COPS3 PAFAH1B2 MAP2K1	5.52e-05	145	158	6	28846114
Pubmed	Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney.	SLC22A25 SLC22A9	6.13e-05	3	158	2	17079864
Pubmed	RhoA, RhoB and RhoC have different roles in cancer cell migration.	RHOA RHOC	6.13e-05	3	158	2	23488932
Pubmed	C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3.	TFE3 MITF	6.13e-05	3	158	2	20214879
Pubmed	Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading.	FLNB RHOA	6.13e-05	3	158	2	28175289
Pubmed	A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.	RHOA RHOC	6.13e-05	3	158	2	12939257
Pubmed	Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma.	RHOA RHOC	6.13e-05	3	158	2	17018591
Pubmed	RhoA and RhoC differentially modulate estrogen receptor α recruitment, transcriptional activities, and expression in breast cancer cells (MCF-7).	RHOA RHOC	6.13e-05	3	158	2	24096540
Pubmed	Structural and mechanistic insights into the interaction between Rho and mammalian Dia.	RHOA RHOC	6.13e-05	3	158	2	15864301
Pubmed	Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.	RHOA RHOC	6.13e-05	3	158	2	29500478
Pubmed	RhoA, RhoB and RhoC differentially regulate endothelial barrier function.	RHOA RHOC	6.13e-05	3	158	2	28949796
Pubmed	Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and tolerance.	TFE3 MITF	6.13e-05	3	158	2	38444862
Pubmed	Renal expression of organic anion transporter Oat5 in rats and mice exhibits the female-dominant sex differences.	SLC22A25 SLC22A9	6.13e-05	3	158	2	20865662
Pubmed	Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia.	CFAP54 CFAP221	6.13e-05	3	158	2	32704025
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	6.13e-05	3	158	2	9971820
Pubmed	Polypeptide chain release factor eRF3 is a novel molecular partner of survivin.	GSPT1 GSPT2	6.13e-05	3	158	2	23377885
Pubmed	A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.	RHOA RHOC	6.13e-05	3	158	2	21087931
Pubmed	RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication.	RHOA RHOC	6.13e-05	3	158	2	20697357
Pubmed	Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases.	RHOA RHOC	6.13e-05	3	158	2	24447566
Pubmed	Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.	LRRK2 FIS1	6.13e-05	3	158	2	22639965
Pubmed	Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells.	RHOA RHOC	6.13e-05	3	158	2	19477269
Pubmed	RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.	RHOA RHOC	6.13e-05	3	158	2	21757538
Pubmed	Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.	EEFSEC MSH2	6.13e-05	3	158	2	10992298
Pubmed	RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.	RHOA RHOC	6.13e-05	3	158	2	28536953
Pubmed	Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.	SHOC2 PPP1CC	6.13e-05	3	158	2	36175670
Pubmed	The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.	TFE3 MITF	6.13e-05	3	158	2	11818452
Pubmed	LRRK2, GBA and SMPD1 Founder Mutations and Parkinson's Disease in Ashkenazi Jews.	LRRK2 SMPD1	6.13e-05	3	158	2	27449028
Pubmed	Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter.	SLC22A25 SLC22A9	6.13e-05	3	158	2	16150593
Pubmed	Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.	GSPT1 GSPT2	6.13e-05	3	158	2	9712840
Pubmed	Divergence of Rho residue 43 impacts GEF activity.	RHOA RHOC	6.13e-05	3	158	2	22673745
Interaction	SRGAP1 interactions	ARHGAP42 OPHN1 RHOA SORBS3 DMD RAPGEF2 LNX1	5.68e-06	92	150	7	int:SRGAP1
Interaction	CCDC8 interactions	FLNB GOPC DSG2 MATR3 HAUS5 PSMD1 MSH2 DICER1 SF1 MYO5C RHOA EXD2 AFG3L2 PKP1 EEA1 CNOT1 ATP5F1B	8.11e-06	656	150	17	int:CCDC8
Interaction	HSBP1 interactions	SLC4A2 TAOK2 KIFC3 EEA1 LNX1 MPP7	8.85e-06	65	150	6	int:HSBP1
Interaction	ECT2 interactions	FLNB SLC22A25 DSG2 MATR3 PSMD1 RRP8 VPS36 MYO5C PPP1CC RHOA ACSL1 RHOC AFAP1 GTF2I RRP9 ABCG2 ADGRF3 KIFC3 CPSF7 RPAP2	9.74e-06	887	150	20	int:ECT2
Interaction	MYO19 interactions	ARHGAP42 FLNB DSG2 FIS1 DENND2B MYO5C PPP1CC RHOA AFAP1 EXD2	1.98e-05	252	150	10	int:MYO19
Interaction	LAMTOR1 interactions	PALD1 ITCH GOPC DSG2 VPS33A INPP5F TFE3 SLC4A2 GGA3 RHOA RHOC AFG3L2 EEA1 DMD PCDH7 MPP7 ATP5F1B	2.77e-05	722	150	17	int:LAMTOR1
Interaction	EGLN3 interactions	GOPC DSG2 HAUS5 PSMD1 MSH2 SUCLA2 LRCH1 DICER1 GSPT1 PPP1CC TAOK2 RHOA ACSL1 GTF2I EXD2 AFG3L2 TTC17 TTC13 LNX1 ZNF281 CNOT1 DNM2 ATP5F1B RPAP2	3.12e-05	1296	150	24	int:EGLN3
Interaction	ARHGAP26 interactions	ARHGAP42 PDE6B OPHN1 RHOA SORBS3 DMD RAPGEF2	3.24e-05	120	150	7	int:ARHGAP26
Interaction	CTTN interactions	FLNB MATR3 SF1 GSPT1 MYO5C GSPT2 TINF2 KIFC3 ARHGAP8 CNOT1 PCDH7 DNM2 CPSF7	3.30e-05	450	150	13	int:CTTN
Interaction	ACTC1 interactions	FLNB MSH2 SF1 TFE3 MYO5C PPP1CC RHOA RHOC AFAP1 GTF2I TTC17 DMD TAF6 ATP5F1B CPSF7 CDK7	6.21e-05	694	150	16	int:ACTC1
Coexpression	GSE43863_NAIVE_VS_LY6C_LOW_CXCR5NEG_CD4_EFF_TCELL_D6_LCMV_UP	MANBA MAT2A LRRK2 TWNK RFFL BCL2A1 ZNF10 SLC22A9 LNX1	1.70e-06	193	149	9	M9720
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSG2 SYT9 HS3ST5 IRF6 ITGB6 MYO5C KIFC3 MPP7	1.96e-07	183	149	8	274483009b309289e4cb84beedf6806430db6ff6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HS3ST5 IRF6 MYO5C CFAP54 ZNF804B MITF DMD MPP7	2.72e-07	191	149	8	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HS3ST5 IRF6 MYO5C CFAP54 ZNF804B MITF DMD MPP7	3.06e-07	194	149	8	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PALD1 LRRK2 BCL2A1 NABP1 ACSL1 DPEP2	1.92e-06	110	149	6	854f21560ce7cb5e1923403b6d04df3d804431e2
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO9A SYT9 HS3ST5 ITGB6 MYO5C KIFC3 MPP7	2.27e-06	177	149	7	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO9A SYT9 HS3ST5 ITGB6 MYO5C KIFC3 MPP7	2.63e-06	181	149	7	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSG2 SYT9 HS3ST5 IRF6 ITGB6 MYO5C KIFC3	3.04e-06	185	149	7	3bef59cc0aa939d2a7e52f0f6c61bc00528fe50b
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSG2 HS3ST5 IRF6 ITGB6 MYO5C RRP9 KIFC3	3.04e-06	185	149	7	0c247a3f394c42e2a6f67fee3d9cf33096fecd13
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSG2 HS3ST5 IRF6 ITGB6 MYO5C RRP9 KIFC3	3.27e-06	187	149	7	ff26a533d310126521efe1d05cf8b9d32e524550
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	LRRK2 DENND2B ITGB6 MYO5C RANBP17 CFAP221 MPP7	3.89e-06	192	149	7	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	MOK IQCH CASC2 AK7 CFAP54 CFAP221 DMD	4.02e-06	193	149	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	IRF6 MYO5C CFAP54 ZNF804B MITF DMD MPP7	4.16e-06	194	149	7	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MOK PALD1 UBD AZIN2 LRRK2 ZNF10	1.11e-05	149	149	6	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MOK PALD1 UBD AZIN2 LRRK2 ZNF10	1.15e-05	150	149	6	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	MOK AZIN2 LRRK2 ZNF10 AFG3L2 IPO13	3.13e-05	179	149	6	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	Control-Epithelial_alveolar-AT_1-AT1-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSG2 SYT9 HS3ST5 IRF6 ITGB6 MYO5C	3.43e-05	182	149	6	a95956ce4adccb34cc0c47ebfa1878ce4617904e
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic-Neutrophil\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LRRK2 BCL2A1 NABP1 ACSL1 ARMH2 BPI	3.43e-05	182	149	6	1932d77491d6d46278f01fd70eb469ef1b356619
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PALD1 MAT2A NABP1 CCDC38 ACSL1 SDS	3.43e-05	182	149	6	16186b7a0c33caa48631962381e3ab7e5d166163
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LRRK2 BCL2A1 NABP1 ACSL1 ARMH2 BPI	3.54e-05	183	149	6	cfbf8539104cef9ca830ad4f6bb278746f7078f7
ToppCell	cellseq2-Immune-Hematopoietic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LRRK2 BCL2A1 NABP1 ACSL1 ARMH2 BPI	3.54e-05	183	149	6	324ec4374b552da7ce03809945b3a0798342d4ba
ToppCell	E12.5-Epithelial-airway_epithelial_cell-club_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DSG2 VPS36 MYO5C ACSL1 ARHGAP8 LNX1	3.65e-05	184	149	6	a69c3c57cd939b2888f548a0fbca3392ad310445
ToppCell	E12.5-Epithelial-airway_epithelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DSG2 VPS36 MYO5C ACSL1 ARHGAP8 LNX1	3.65e-05	184	149	6	3df78b17098b50e1a7f2c8791bf2d0806328330a
ToppCell	LPS_only-Epithelial_alveolar-AT_1-AT1-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSG2 IRF6 ITGB6 MYO5C RRP9 KIFC3	3.76e-05	185	149	6	68f428e169cfb77de970bdfdeea9b9f16f68d2ba
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LRRK2 ITGB6 MYO5C CFAP221 DMD MPP7	3.87e-05	186	149	6	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO9A HS3ST5 ITGB6 MYO5C KIFC3 MPP7	3.87e-05	186	149	6	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO9A SYT9 ITGB6 MYO5C KIFC3 MPP7	3.99e-05	187	149	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	MOK IQCH CASC2 AK7 CFAP54 CFAP221	4.23e-05	189	149	6	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRRK2 ITGB6 MYO5C RANBP17 CFAP221 MPP7	4.36e-05	190	149	6	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LRRK2 ITGB6 MYO5C RANBP17 CFAP221 MPP7	4.49e-05	191	149	6	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LRRK2 ITGB6 MYO5C RANBP17 CFAP221 MPP7	4.49e-05	191	149	6	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	LRRK2 ITGB6 MYO5C RANBP17 CFAP221 MPP7	4.62e-05	192	149	6	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	IRF6 ITGB6 MYO5C MITF DMD LNX1	4.62e-05	192	149	6	c15841f35e24d6ef6ce2a9a6dc62e66efdc3d9d5
ToppCell	COPD-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	MOK IQCH CASC2 AK7 CFAP54 CFAP221	4.62e-05	192	149	6	eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	MOK IQCH CASC2 AK7 CFAP54 CFAP221	4.62e-05	192	149	6	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MOK CASC2 DENND2B CFAP54 CFAP221 PCDH7	4.76e-05	193	149	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	facs-Trachea-3m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DSG2 IRF6 ITGB6 MYO5C ZNF804B ARHGAP8	4.76e-05	193	149	6	c5925b3b5d19098e3987789d68a493d7fd548ac9
ToppCell	facs-Trachea-3m-Epithelial-glandular_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DSG2 IRF6 ITGB6 MYO5C ZNF804B ARHGAP8	4.76e-05	193	149	6	6905de261d90dfe3dd2c2cf5b2e26afb2bcc3d5b
ToppCell	facs-Trachea-3m-Epithelial-glandular_epithelial-lung_secretory_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DSG2 IRF6 ITGB6 MYO5C ZNF804B ARHGAP8	4.76e-05	193	149	6	f73630725f093c646bdaf178c39505c04a16e2c6
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MOK LRRK2 CHI3L2 AK7 CFAP54 CFAP221	4.76e-05	193	149	6	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	LRRK2 BCL2A1 INPP5F ACSL1 EEA1 DNAH8	4.76e-05	193	149	6	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	LRRK2 ITGB6 MYO5C RANBP17 CFAP221 MPP7	4.76e-05	193	149	6	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	MANBA LRRK2 NABP1 ACSL1 MITF SDS	5.04e-05	195	149	6	ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO9A LRRK2 ITGB6 MYO5C RANBP17 CFAP221	5.04e-05	195	149	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP42 DSG2 IRF6 ITGB6 MYO5C PCDH7	5.33e-05	197	149	6	d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP42 DSG2 IRF6 ITGB6 MYO5C PCDH7	5.33e-05	197	149	6	80b05c8ad9c1edc5dea3236079372475431343fe
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LRRK2 ITGB6 MYO5C RANBP17 CFAP221 MPP7	5.64e-05	199	149	6	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO9A ITGB6 MYO5C RANBP17 CFAP221 MPP7	5.64e-05	199	149	6	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO9A ITGB6 MYO5C RANBP17 CFAP221 MPP7	5.64e-05	199	149	6	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT2-2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DSG2 LRRK2 CHI3L2 ITGB6 MYO5C MPP7	5.80e-05	200	149	6	3c251ad03fbbdae91dfd9037880ba43adbb03807
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT2-2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	DSG2 LRRK2 CHI3L2 ITGB6 MYO5C MPP7	5.80e-05	200	149	6	c905451425d1c24773bb0ca69bcf0309b277d2f1
ToppCell	distal-Epithelial\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DSG2 LRRK2 IRF6 CHI3L2 ITGB6 CFAP221	5.80e-05	200	149	6	0a97080f694738bb882787cee21b91a4d5757b7a
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-AT2-2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	DSG2 LRRK2 CHI3L2 ITGB6 MYO5C MPP7	5.80e-05	200	149	6	35c05cae30cd6b323d2662f1396ddeab08bc75fc
ToppCell	droplet-Liver-LIVER_NPC-30m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB UBD LACTB2 PNPLA7 SDS	1.05e-04	139	149	5	e363c69b58cff8571ca75b91a3d052f9cbccac27
Disease	neurodegenerative disease (implicated_via_orthology)	LRRK2 SLC1A7 GGA3 RHOA RHOC AFG3L2 PNPLA7	7.85e-06	145	145	7	DOID:1289 (implicated_via_orthology)
Disease	mismatch repair cancer syndrome (is_implicated_in)	TAF1B MSH2 SLC22A9	2.48e-05	12	145	3	DOID:0112182 (is_implicated_in)
Disease	lysosomal storage disease (implicated_via_orthology)	TFE3 GGA3 MITF	6.21e-05	16	145	3	DOID:3211 (implicated_via_orthology)
Disease	X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance (implicated_via_orthology)	ARHGAP42 OPHN1	1.43e-04	4	145	2	DOID:0080311 (implicated_via_orthology)
Disease	Lynch syndrome (is_implicated_in)	TAF1B MSH2 SLC22A9	2.18e-04	24	145	3	DOID:3883 (is_implicated_in)
Disease	melanoma	IQCH GOPC HS3ST5 JAKMIP2 SF1 MITF MAP2K1	2.35e-04	248	145	7	C0025202
Disease	ovarian carcinoma (is_marker_for)	RHOA RHOC MAP2K1	3.48e-04	28	145	3	DOID:4001 (is_marker_for)
Disease	ulcerative colitis (implicated_via_orthology)	RHOA RHOC	4.96e-04	7	145	2	DOID:8577 (implicated_via_orthology)
Disease	blood pressure, chronic obstructive pulmonary disease	ARHGAP42 EEFSEC GTF2I	5.19e-04	32	145	3	EFO_0000341, EFO_0004325
Disease	peroxisomal biogenesis disorder (implicated_via_orthology)	RHOA RHOC	6.59e-04	8	145	2	DOID:0080377 (implicated_via_orthology)
Disease	RASopathy (implicated_via_orthology)	SHOC2 MAP2K1	8.44e-04	9	145	2	DOID:0080690 (implicated_via_orthology)
Disease	Mitochondrial DNA Deletion Syndromes	TWNK SUCLA2	8.44e-04	9	145	2	cv:CN043632
Disease	descending aortic diameter	FLNB COL6A3 AFAP1 LNX1	9.47e-04	88	145	4	EFO_0021788
Disease	valine measurement	MOK BPI ABCG2	1.01e-03	40	145	3	EFO_0009792
Disease	estrogen measurement	SLC22A25 SLC22A9	1.05e-03	10	145	2	EFO_0011007
Disease	Secondary Biliary Cholangitis	UBD SLC4A2 ABCG2	1.16e-03	42	145	3	C0238065
Disease	Biliary cirrhosis	UBD SLC4A2 ABCG2	1.16e-03	42	145	3	C0023892
Disease	Biliary Cirrhosis, Primary, 1	UBD SLC4A2 ABCG2	1.16e-03	42	145	3	C4551595
Disease	hereditary spastic paraplegia (implicated_via_orthology)	AFG3L2 PNPLA7 DNM2	1.24e-03	43	145	3	DOID:2476 (implicated_via_orthology)
Disease	Noonan Syndrome 1	SHOC2 MAP2K1	1.28e-03	11	145	2	C4551602
Disease	Turner Syndrome, Male	SHOC2 MAP2K1	1.28e-03	11	145	2	C0041409
Disease	Female Pseudo-Turner Syndrome	SHOC2 MAP2K1	1.28e-03	11	145	2	C1527404
Disease	cleft palate (is_implicated_in)	FLNB IRF6	1.53e-03	12	145	2	DOID:674 (is_implicated_in)
Disease	Primary biliary cirrhosis	UBD SLC4A2 ABCG2	1.61e-03	47	145	3	C0008312
Disease	corneal resistance factor	COL6A3 IQCH ABCA8 RHOA RANBP17 AFAP1 LNX1 DNM2	1.80e-03	451	145	8	EFO_0010067
Disease	fatty acid measurement, fetal genotype effect measurement, breast milk measurement	FAM135B ZNF804B	1.81e-03	13	145	2	EFO_0005110, EFO_0007959, EFO_0009092
Disease	fatty acid measurement, breast milk measurement, parental genotype effect measurement	FAM135B ZNF804B	2.10e-03	14	145	2	EFO_0005110, EFO_0005939, EFO_0009092
Disease	cancer (implicated_via_orthology)	VPS36 MSH2 ITGB6 PPP1CC GRTP1 MAP2K1	2.16e-03	268	145	6	DOID:162 (implicated_via_orthology)
Disease	coronary artery disease	ARHGAP42 COL6A3 UBD MAT2A CNPY4 ZC2HC1C DENND2B ABCA8 OPHN1 RHOA MITF ABCG2 RAPGEF2 LNX1	2.32e-03	1194	145	14	EFO_0001645
Disease	RASopathy	SHOC2 MAP2K1	2.41e-03	15	145	2	cv:C5555857
Disease	response to radiation, Urinary retention	COL6A3 DNM2	3.11e-03	17	145	2	GO_0009314, HP_0000016
Disease	migraine disorder, type 2 diabetes mellitus	RANBP17 AFAP1 GTF2I	3.24e-03	60	145	3	MONDO_0005148, MONDO_0005277
Disease	creatinine measurement	EEFSEC MANBA PSMD1 SLC1A7 FAM135B RHOA CUTC GRTP1 MITF ABCG2 PNPLA7 UNC80	3.79e-03	995	145	12	EFO_0004518
Disease	Noonan-Like Syndrome With Loose Anagen Hair	SHOC2 MAP2K1	3.88e-03	19	145	2	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	SHOC2 MAP2K1	3.88e-03	19	145	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	SHOC2 MAP2K1	3.88e-03	19	145	2	C1275081
Disease	Costello syndrome (disorder)	SHOC2 MAP2K1	3.88e-03	19	145	2	C0587248
Disease	susceptibility to mononucleosis measurement	DMD DNAH8 PCDH7	4.81e-03	69	145	3	EFO_0008403
Disease	renal cell carcinoma (is_implicated_in)	TFE3 ABCG2 MAP2K1	4.81e-03	69	145	3	DOID:4450 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PKIQEVKEQRVTGLL	SLC4A2	1081	P04920
PAEKRQALLGVIKAL	ADGRF3	961	Q8IZF5
LINVKRNKGLIFPLE	CFAP54	536	Q96N23
LVQKGVKVDLGIPLE	CNPY4	126	Q8N129
LVERKQPLRGIGILK	COPS3	111	Q9UNS2
QPLRGIGILKQAIDK	COPS3	116	Q9UNS2
RVIGGLEKKTQVLQP	AFG3L2	551	Q9Y4W6
ILGVEGQQLVRPKKL	ADAM7	21	Q9H2U9
EGVENKLIPGLKIIV	ACSL1	211	P33121
INLGLKKEPNVARVG	SMPD1	101	P17405
PIEKRAQAAQKIGLL	ARMH2	71	H3BNL8
IIAKKEVLLDQPGRE	AZIN2	291	Q96A70
VNAGRKPQAILEEKL	AFAP1	601	Q8N556
RKPVEKEILSNINGI	ABCG2	56	Q9UNQ0
EGILIKKLLRQQIAP	BCL2A1	96	Q16548
LKGAKITRLQDQQVP	CHI3L2	311	Q15782
EQVKLLVEELPLRQG	DMD	2251	P11532
LVEELPLRQGILKQL	DMD	2256	P11532
VLNRLIKEAGKQDPE	DICER1	456	Q9UPY3
QKIEQVLKEQPGRGL	DENND2B	286	P78524
LVPLKETIKGFQQIL	ATP5F1B	481	P06576
LDQVLKKAGRIPEQI	MAP2K1	151	Q02750
LIKGVKRILENPQGL	RANBP17	306	Q9H2T7
LLELLPGKVLNGEKV	CPSF7	141	Q8N684
EVKIKGNNLVALLPE	IQCH	316	Q86VS3
LLIKPLENFRKEQIG	OPHN1	111	O60890
QGVGPIRKVLLLKED	GOPC	281	Q9HD26
LGNIGLIVIIKINPK	OR5D18	41	Q8NGL1
VVLENQKKLEGIRPE	PALD1	391	Q9ULE6
DPLRTGKIKIQDILA	PPP2R3C	231	Q969Q6
GNNVEKPLELRIKVL	DSG2	136	Q14126
RNKGEKPEALIVALQ	JAKMIP2	6	Q96AA8
PLLVRQIEGLKLLQK	LONP2	216	Q86WA8
VLRIPNRGIDLLKKD	MATR3	576	P43243
QNKIKIVGLGLLRVL	GPR155	201	Q7Z3F1
RGLEKAKVIQPDGVL	MTO1	366	Q9Y2Z2
LEIVKKNFDLRPGVI	MAT2A	346	P31153
LIGEILGQLDVKLLK	BPIFA3	211	Q9BQP9
QKLLRKFGEDLPIQL	EXD2	606	Q9NVH0
APGENLKIRLKGIEE	GSPT2	486	Q8IYD1
IRKGIVLLEELLPKG	FIS1	51	Q9Y3D6
LLAVQITDQEGKPKR	FLNB	1551	O75369
LVQQLPKAIIIGVRK	HS3ST5	86	Q8IZT8
ELLIQVGKLNPEAVR	PCNX4	1101	Q63HM2
QVEILKNKPLSVGRQ	ITGB6	81	P18564
IKKLPRNPQREEIIG	LACTB2	101	Q53H82
RKELLGKGDLQPQLD	MTSS2	151	Q765P7
KQPQLIVKGALDREQ	PCDH7	256	O60245
ELGVVRKFQIPQEVL	PDE6B	526	P35913
EVLPLKANLAKQEGR	DNAH8	3286	Q96JB1
PVGVGLNELKRKLLI	MPP7	376	Q5T2T1
VKLVGRDPKNNLEAL	LCN1	131	P31025
EQLGIKLVRKVDEPG	LNX1	391	Q8TBB1
KLGSLPEEIGQLKQL	LRCH1	176	Q9Y2L9
FKIRDQLVVGQLIPD	LRRK2	1511	Q5S007
REQIPLLEQKVLIGA	MMAA	386	Q8IVH4
KLPGQERLLEEVEKL	GOLGA6L9	241	A6NEM1
INKELEGPQIAVRLL	GGA3	36	Q9NZ52
PENILIKQDVLKLGD	MOK	131	Q9UQ07
VLILQDRKLVTGPGK	TWNK	586	Q96RR1
KLLKQALERIPELQG	HAUS5	576	O94927
LNKKRAIPNQGEILV	DNM2	506	P50570
VAPGENLKIRLKGIE	GSPT1	356	P15170
IRKQILEELEKPGAG	PNPLA7	361	Q6ZV29
AKQRLVVLVKDNGEP	PCDHB16	636	Q9NRJ7
RILNKPVGLKDLESI	ITCH	666	Q96J02
AKQRLVVLVKDNGEP	PCDHB7	636	Q9Y5E2
ELKQAGRKGNIIPLT	ERVK-10	66	P87889
ELKQAGRKGNIIPLT	ERVK-19	66	Q9YNA8
ELKQAGRKGNIIPLT	ERVK-21	66	P62683
ELKQAGRKGNIIPLT	ERVK-24	66	P63145
ELKQAGRKGNIIPLT	ERVK-5	66	Q9HDB9
ELKQAGRKGNIIPLT	ERVK-6	66	Q7LDI9
ELKQAGRKGNIIPLT	ERVK-7	66	P63130
ELKQAGRKGNIIPLT	ERVK-8	66	P62685
ELKQAGRKGNIIPLT	ERVK-9	66	P63126
ELKQAGRKGNIIPLT	HERVK_113	66	P62684
VIQDLKTELLQRPGI	EEA1	206	Q15075
LQDGIVNPTIRKDLK	ATMIN	111	O43313
LPVIGNILQIDIKDV	CYP2C19	36	P33261
KKNPIVFIRGILQAL	SLC1A7	321	O00341
RTEALEQGGLPKKLI	CDK7	331	P50613
PILVLPRVNEKLQKG	BPI	441	P17213
QEVLGELVRAKLPAV	GRTP1	201	Q5TC63
VNLLEKLPIGTQQIR	COL6A3	266	P12111
QVPDLVKKEVQRILG	GPAT2	136	Q6NUI2
DNKKLPQGIIIVFRL	CASC2	36	Q8IU53
RPNIILGLVICQKIK	DIDO1	1186	Q9BTC0
IELQPGKRIVELFVN	MANBA	266	O00462
DGLNPIQKLVKVESR	CCDC38	451	Q502W7
GLPLIKRLIEQAKGR	CUTC	181	Q9NTM9
LKPDLKQRLRQQLVG	DND1	216	Q8IYX4
PDDILQLLKKNGGVV	DPEP2	296	Q9H4A9
PIELLGNVKSIREKI	CYP7B1	231	O75881
KGLNLKIPRVIALEN	FAM135B	876	Q49AJ0
LAREQINGIIEVPAK	GRIK5	46	Q16478
IPRLEKIIQVGNRIK	GTF2I	521	P78347
IRLEPLLQKVVEKGA	PNMA1	266	Q8ND90
LIINNKPEEGLKELR	SLC22A25	286	Q6T423
VIQKLQLEGNLRTPL	SDS	281	P20132
ILIRQKALVGKLPGD	INPP5F	66	Q9Y2H2
KLIPLVLGLQEQLRQ	IPO13	281	O94829
RPAILEKGQGRIILK	MSH2	621	P43246
QAKIIVLGLLPRGEK	PAFAH1B2	131	P68402
PIILVGNKKDLRQDE	RHOC	111	P08134
DGKPLERKLILVQVI	IRF6	381	O14896
KLVNNKVIQARPGII	CFAP221	51	Q4G0U5
GLKEKGLPQIARLLQ	PKP1	591	Q13835
LQKQEQLTGIGRIKP	SYT9	186	Q86SS6
DVIKTLILPRLQQEG	TAF6	386	P49848
GKIPQELEKQLVALI	TMEM106A	66	Q96A25
PIILVGNKKDLRNDE	RHOA	111	P61586
IRDIKPGLKNLNVVF	NABP1	11	Q96AH0
PLEVVKTRLQLQGEL	SLC25A34	26	Q6PIV7
VLIAPLEKFRKEQIG	ARHGAP42	111	A6NI28
KEELVLLVLGQQPVI	RFFL	126	Q8WZ73
LIINNKPEEGLKELR	SLC22A9	286	Q8IVM8
LKNLGVGPELKNDVL	TAF1B	91	Q53T94
VLRDLLGKEPQEKLE	KIFC3	581	Q9BVG8
GEKKPIDQRLEGIVN	PSMD1	121	Q99460
SIRENKIKQLPAEIG	SHOC2	221	Q9UQ13
ILGKEGATLEPKQQR	TAOK2	801	Q9UL54
KDLEIKIPVVVRLQG	SUCLA2	396	Q9P2R7
ELKQAGRKGNIIPLT	ERVK-9	66	P63128
KGILPQEVDKEIQRV	ABCA8	586	O94911
QIRLKVGGVDPKQLA	CNOT1	1556	A5YKK6
GVIKQRRLPDQLSKL	RAPGEF2	661	Q9Y4G8
NGLRKILKVVGQVPD	UNC45B	326	Q8IWX7
QDQVLLLGSKILKPR	UBD	46	O15205
LAVEIPDLIQKGVIQ	UFC1	146	Q9Y3C8
LVVVLNKIDLLPEGK	EEFSEC	141	P57772
NKIDLLPEGKRQAAI	EEFSEC	146	P57772
NPKGLLEVREALEKV	TTC13	636	Q8NBP0
KAPRVAIEKQLQQGI	ZNF804B	136	A4D1E1
LKILQNLAGEPRVIA	UNC80	2511	Q8N2C7
AKQLAGILQVPLEER	VPS36	246	Q86VN1
NINDRIKELGTLIPK	MITF	326	O75030
NINDRIKELGTLIPK	TFE3	361	P19532
GRLQKLVAKEIQAPA	RRP9	121	O43818
QVCPEVGKRNLLKVL	RPAP2	356	Q8IXW5
LDIKPINERLRELKG	SMC1B	576	Q8NDV3
LKAKVVVELILQGRP	TINF2	61	Q9BSI4
IGTGIDELQKRVPKL	ZNF281	451	Q9Y2X9
LQELETGQRPKKPLV	SORBS3	246	O60504
EEANRVLKPGGLLKV	RRP8	376	O43159
RLDLQGIRVLKKGPQ	TTC17	801	Q96AE7
LLEVRGSKPGKNVQL	PPP1CC	16	P36873
ELQPGVKAVQVVLRI	PIAS4	181	Q8N2W9
LIPVLNGLEKKEVIQ	SYMPK	891	Q92797
LKDKNQGELIPPVLR	ARHGAP8	231	P85298
KENENGELQKIILPR	ZC2HC1C	256	Q53FD0
QLTKPDVILRLEKGE	ZNF10	56	P21506
TGVLPERQKLLGLKV	UBLCP1	36	Q8WVY7
LKGNRLPAADVKNII	VPS33A	66	Q96AX1
REKGDPTEKQLQIIL	TBX19	31	O60806
KLKPLGEQERAVILE	THOP1	301	P52888
KIEILTPEVNKGLRN	PRPF18	111	Q99633
QRQLLNKKGFGEPVL	UIMC1	311	Q96RL1
LIGPRGNTLKNIEKE	SF1	156	Q15637
KQELGKGPQLIIDIR	TRAV13-1	56	A0A0B4J241
LAIKQLIKEIGEPRN	AK7	596	Q96M32
QNLILDLKPRGVVVN	MYO5C	1376	Q9NQX4
LRETKPEVGLVNIKG	MYO9A	1166	B2RTY4