Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

8.01e-085413GO:0030156
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3C RIMBP3B

4.27e-0536393GO:0007274
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

1.90e-0528393GO:0002177
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

8.44e-0619303MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

1.16e-0521303MP:0008893
MousePhenoabsent zigzag hairs

EDARADD CUX1

2.66e-054302MP:0006366
MousePhenoabsent guard hair

EDARADD CUX1

9.29e-057302MP:0006365
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B

1.11e-0444303MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B

1.19e-0445303MP:0009376
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

2.29e-0456303MP:0009237
MousePhenodecreased circulating calcium level

TCIRG1 ARHGAP22 GNAS DPF3

4.42e-04169304MP:0000195
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3C RIMBP3B

5.22e-0474303MP:0009232
MousePhenoabnormal circulating calcium level

TCIRG1 ARHGAP22 GNAS KDM4C DPF3

5.66e-04323305MP:0001562
MousePhenodecreased calcium level

TCIRG1 ARHGAP22 GNAS DPF3

5.73e-04181304MP:0014538
MousePhenoabnormal guard hair morphology

EDARADD CUX1

5.94e-0417302MP:0000397
MousePhenoabnormal calcium level

TCIRG1 ARHGAP22 GNAS KDM4C DPF3

7.93e-04348305MP:0020879
MousePhenoabnormal zigzag hair morphology

EDARADD CUX1

8.26e-0420302MP:0000402
DomainCABLES1/2

CABLES2 CABLES1

4.03e-062382IPR012388
DomainSpeedy

SPDYE21 SPDYE16

2.19e-0411382IPR020984
DomainSpy1

SPDYE21 SPDYE16

2.19e-0411382PF11357
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B

5.32e-0478383PF14604
DomainFN3

RIMBP3 RIMBP3C RIMBP3B LRFN5

6.95e-04199384PS50853
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

7.08e-0486383IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

7.08e-0486383PF07653
DomainFN3_dom

RIMBP3 RIMBP3C RIMBP3B LRFN5

8.35e-04209384IPR003961
DomainCyclin_N

CABLES2 CABLES1

2.05e-0333382IPR006671
DomainCyclin_N

CABLES2 CABLES1

2.05e-0333382PF00134
Domain-

RIMBP3 RIMBP3C FCRL5 CAMTA1 RIMBP3B LRFN5

2.05e-036633862.60.40.10
DomainCYCLIN

CABLES2 CABLES1

2.71e-0338382SM00385
DomainIg-like_fold

RIMBP3 RIMBP3C FCRL5 CAMTA1 RIMBP3B LRFN5

2.81e-03706386IPR013783
Domain-

CABLES2 CABLES1

2.99e-03403821.10.472.10
DomainCyclin-like

CABLES2 CABLES1

3.45e-0343382IPR013763
DomainCUB

CSMD3 TLL2

4.46e-0349382PF00431
DomainCUB

CSMD3 TLL2

4.64e-0350382SM00042
Domain-

CSMD3 TLL2

5.01e-03523822.60.120.290
DomainCUB

CSMD3 TLL2

5.20e-0353382PS01180
DomainCUB_dom

CSMD3 TLL2

6.00e-0357382IPR000859
DomainRhoGAP

ARHGAP22 STARD8

7.06e-0362382SM00324
DomainRhoGAP

ARHGAP22 STARD8

7.28e-0363382PF00620
DomainTSP_1

ADAMTS12 THSD7B

7.28e-0363382PF00090
DomainRHOGAP

ARHGAP22 STARD8

7.51e-0364382PS50238
DomainRhoGAP_dom

ARHGAP22 STARD8

7.51e-0364382IPR000198
Domain-

ARHGAP22 STARD8

7.51e-03643821.10.555.10
DomainTSP1

ADAMTS12 THSD7B

7.73e-0365382SM00209
DomainTSP1_rpt

ADAMTS12 THSD7B

7.73e-0365382IPR000884
DomainTSP1

ADAMTS12 THSD7B

7.73e-0365382PS50092
DomainSH3

RIMBP3 RIMBP3C RIMBP3B

9.55e-03216383PS50002
DomainSH3

RIMBP3 RIMBP3C RIMBP3B

9.55e-03216383SM00326
DomainSH3_domain

RIMBP3 RIMBP3C RIMBP3B

1.00e-02220383IPR001452
DomainMetalloPept_cat_dom

ADAMTS12 TLL2

1.18e-0281382IPR024079
Domain-

ADAMTS12 TLL2

1.18e-02813823.40.390.10
DomainRho_GTPase_activation_prot

ARHGAP22 STARD8

1.38e-0288382IPR008936
DomainPHD

KDM4C DPF3

1.41e-0289382SM00249
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

6.08e-09441319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

1.52e-08541317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

5.49e-071441317662146
Pubmed

ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways.

CABLES2 CABLES1

4.06e-06341214637168
Pubmed

ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.

CABLES2 CABLES1

1.35e-05541211955625
Pubmed

Genome-wide and candidate gene association study of cigarette smoking behaviors.

BBX CABLES1

1.05e-041341219247474
Pubmed

Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus.

CUX1 KIFC1

2.81e-042141224483844
Pubmed

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

GNAS ZNF831

5.39e-042941221909115
Pubmed

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer.

GNAS PANK4

5.78e-043041234285210
Pubmed

Genome-wide association study of periodontal pathogen colonization.

CAMTA1 CSMD3

6.17e-043141222699663
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

STARD8 GSE1

1.08e-03414128724849
Pubmed

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

GNAS ZNF831

1.13e-034241221909110
Pubmed

OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.

ARHGAP22 TLL2

1.13e-034241226166575
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

1.37e-0411141322q11.21
Cytoband1p36.32

CCDC27 PANK4

1.95e-04234121p36.32
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE21 SPDYE18 SPDYE16

1.84e-03271413chr7q11
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3C RIMBP3B

6.22e-03419413chr22q11
CytobandEnsembl 112 genes in cytogenetic band chr20q13

CABLES2 GNAS ZNF831

6.35e-03422413chr20q13
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP22 STARD8

1.11e-0350182721
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

GRB14 ARHGAP22

1.75e-02206182682
CoexpressionBENPORATH_SUZ12_TARGETS

RIMBP3 RIMBP3C GNAS RIMBP3B CSMD3 DPF3 LRFN5 TLL2 CEMIP

2.04e-051035409M9898
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FCRL5 C2orf81 EDARADD CEMIP

1.18e-0515740429622bac6b16bb39cec4319bf4c4f92d33345e8a
ToppCellfacs-MAT-Fat-24m-Lymphocytic-T_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7B LPCAT2 EDARADD CEMIP

1.54e-0516840422fa707689e8d6ca5154103b7374007d644d61c3
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TCIRG1 DPF3 B4GALT6 CABLES1

1.81e-051754040c6cf88818037bef67211c1a8fcb1e7d47711c1d
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

ADAMTS12 THSD7B ZNF831 CABLES1

2.16e-05183404b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

ADAMTS12 THSD7B ZNF831 CABLES1

2.16e-051834043f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRB14 STARD8 HSPA12B PRRT4

2.40e-05188404db0652f000d459493321b53239326706eace598c
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

UTS2R STARD8 THSD7B HSPA12B

2.40e-05188404c90669b51e1902fe7726555290c91c92a911df83
ToppCelldroplet-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRB14 STARD8 HSPA12B PRRT4

2.45e-051894047b6cb745c0a637d6addc105a79059ed488fced39
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRB14 STARD8 HSPA12B PRRT4

2.50e-0519040452213cd2a6a20772d4f49ba9ac0407abafa528db
ToppCelldroplet-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRB14 STARD8 HSPA12B PRRT4

2.66e-0519340425129080f8a40b2988a5d9dfec36ff9e72c27e61
ToppCelldroplet-Lung-nan-21m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRB14 STARD8 HSPA12B PRRT4

2.66e-05193404ffdcbc5caff7fd4cc2e83dd21a05d43b0593d542
ToppCelldroplet-Lung-nan-18m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRB14 STARD8 HSPA12B PRRT4

2.71e-05194404f35f03412b596b6b570b377ba1a607409d984bb1
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRB14 STARD8 HSPA12B PRRT4

2.77e-05195404cad21edd90bf3e2fefdf5773a59cb1a664a69ddd
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRB14 STARD8 HSPA12B PRRT4

2.77e-051954047e0ef92059ff34e368d2324815f49b50e3ca7332
DiseaseColorectal Carcinoma

STARD8 GNAS GSE1 CSMD3 CUX1 CABLES1 PANK4

1.92e-05702367C0009402
Diseaseplatelet component distribution width

STARD8 GNAS CAMTA1 GSE1 ZNF831 CUX1 CABLES1

3.05e-05755367EFO_0007984
Diseaseirritability measurement

CHADL BBX PANK4

1.38e-0482363EFO_0009594
Diseasemean platelet volume

STARD8 GNAS BBX CAMTA1 GSE1 CUX1 CABLES1

2.00e-041020367EFO_0004584
Diseaseimmature platelet fraction

GNAS CUX1 CABLES1

3.65e-04114363EFO_0009187
Diseaseworry measurement

CHADL BBX CAMTA1

8.77e-04154363EFO_0009589
Diseaselysine measurement

AASS DPF3

9.38e-0437362EFO_0005002
Diseaseresponse to sulfasalazine, Drug-induced agranulocytosis

GNAS GSE1

9.38e-0437362EFO_0008324, HP_0012235
Diseasedimethylglycine measurement

CSMD3 DPF3

1.45e-0346362EFO_0010476
DiseaseHypermetropia, Myopia

ARHGAP22 KDM4C DPF3

1.58e-03189363HP_0000540, HP_0000545
Diseasecomparative body size at age 10, self-reported

SPDYE18 GNAS CAMTA1 KDM4C

1.66e-03420364EFO_0009819
Diseasealcohol use disorder measurement

THSD7B CSMD3 LRFN5

2.25e-03214363EFO_0009458
Diseasetuberculosis

LPCAT2 KDM4C DPF3

2.31e-03216363MONDO_0018076
Diseasemelanoma

ZNF831 KDM4C CUX1

3.41e-03248363C0025202
Diseasealcohol consumption measurement

THSD7B CAMTA1 CSMD3 KDM4C LRFN5 CUX1

3.62e-031242366EFO_0007878

Protein segments in the cluster

PeptideGeneStartEntry
RSADRCAKKPWRSGP

GNAS

581

P84996
LPKCSSLPKERHRWN

CAMTA1

61

Q9Y6Y1
GVGKRPKRKCLQWHP

BBX

16

Q8WY36
AKESKPWEPGKRRCA

CSMD3

11

Q7Z407
PWEPGKRRCAKCGRL

CSMD3

16

Q7Z407
ARPKPWHKLSLKGRE

CUX1

1166

P39880
LRKCLALPAMHWPRG

GSE1

1196

Q14687
WERRAPLAPKHIKGI

AASS

36

Q9UDR5
RLLTSWHKCKPPLRL

CALHM1

301

Q8IU99
LWKAHPGKICNRPID

CEMIP

346

Q8WUJ3
PAKRCHLRPCAGWKV

ADAMTS12

1356

P58397
RDARCPEWKPHQKPR

CCDC27

76

Q2M243
RDPQKALCDLHPSWK

RIMBP3B

676

A6NNM3
RDPQKALCDLHPSWK

RIMBP3C

676

A6NJZ7
LRCKARGDPEPAIHW

LRFN5

306

Q96NI6
ARCWRKKRRLHPPED

DPF3

76

Q92784
PSKRPAWDLKGQLCD

KIFC1

131

Q9BW19
CWLSRKAGRKPASDP

FCRL5

871

Q96RD9
WALPTKPRCLHLEKG

PDZD3

321

Q86UT5
AHRAGLAKVIPPKEW

KDM4C

41

Q9H3R0
WACILRRKTPRHKQP

C6orf223

21

Q8N319
HPPEKLLVRDGRRWC

HSPA12B

556

Q96MM6
WLQRLKGPPHKCALI

PANK4

606

Q9NVE7
CPEKLTHPITGWRRK

LPCAT2

91

Q7L5N7
IEPGGHWRPKDCKPR

B4GALT6

141

Q9UBX8
LLDDPQWPCGKHKRV

CABLES1

461

Q8TDN4
RIKLDPCHPTVKNWR

EDARADD

126

Q8WWZ3
NVHWGPPCSRDIKRK

GPATCH2L

401

Q9NWQ4
WRKKGCLRLGTHGSP

GRB14

406

Q14449
KRLDPARLPCHWVRP

C2orf81

341

A6NN90
DCPGWAARKAKRTPA

CHADL

721

Q6NUI6
NLLDDPQWPCGKHKR

CABLES2

306

Q9BTV7
RDPQKALCDLHPSWK

RIMBP3

676

Q9UFD9
CRKAPDGHPLRLWKA

STARD8

851

Q92502
CPHRLGPVLKAGWLK

ARHGAP22

31

Q7Z5H3
DPSPPHRSFCWKRKR

SPDYE16

91

A6NNV3
DPSPPHRSFCWKRKR

SPDYE18

131

P0DV79
DPSPPHRSFCWKRKR

SPDYE21

131

A0A494C086
WRKAPLLGRFCGDKI

TLL2

416

Q9Y6L7
PRCWAKLFRLSPGHA

PRRT4

631

C9JH25
KSLCLPAWGPRAHRA

UTS2R

196

Q9UKP6
DPSPPHRSFCWKRKR

nan

91

A6NJR5
FSLKVGPWSKCRLPH

THSD7B

241

Q9C0I4
GPWSKCRLPHLKEIN

THSD7B

246

Q9C0I4
PWDAKAPEGRLRKCE

ZNF831

326

Q5JPB2
PHKAPALERLLWRAC

TCIRG1

176

Q13488