Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.44e-06114626GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

2.35e-06124626GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

4.19e-06137626GO:0019783
GeneOntologyMolecularFunctioncysteine-type peptidase activity

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

2.87e-05192626GO:0008234
GeneOntologyMolecularFunctionpeptidase activity

USP17L7 ADAMTS19 USP17L4 USP17L2 USP17L1 PCSK6 ADAMTS16 USP17L3 ADAMTS20 USP17L8

3.06e-056546210GO:0008233
GeneOntologyMolecularFunctionATP-dependent diacylglycerol kinase activity

DGKE DGKD

5.12e-0411622GO:0004143
GeneOntologyBiologicalProcessprotein deubiquitination

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

2.04e-06125626GO:0016579
GeneOntologyBiologicalProcessprotein modification by small protein removal

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

4.65e-06144626GO:0070646
GeneOntologyBiologicalProcesspositive regulation of MDA-5 signaling pathway

USP17L2 DDX60

5.31e-054622GO:1900245
GeneOntologyBiologicalProcesspost-translational protein modification

USP17L7 USP17L4 HIF1A USP17L2 USP17L1 RNF144A USP17L3 BAZ1B RNF213 HERC1 USP17L8 FBXL5

7.21e-0510746212GO:0043687
GeneOntologyBiologicalProcesspositive regulation of clathrin-dependent endocytosis

WASL DGKD

8.84e-055622GO:2000370
GeneOntologyBiologicalProcessregulation of MDA-5 signaling pathway

USP17L2 DDX60

1.85e-047622GO:0039533
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP17L7 USP17L4 HIF1A USP17L2 USP17L1 RNF144A USP17L3 RNF213 HERC1 USP17L8 FBXL5

1.86e-0410096211GO:0070647
GeneOntologyCellularComponentRAVE complex

DMXL2 DMXL1

2.51e-053612GO:0043291
DomainUCH

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.15e-0771616PF00443
DomainUSP_2

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.15e-0771616PS00973
DomainUSP_3

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.25e-0772616PS50235
DomainUSP_dom

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.25e-0772616IPR028889
DomainPeptidase_C19_UCH

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.25e-0772616IPR001394
DomainUSP_CS

USP17L7 USP17L2 USP17L1 USP17L3 USP17L8

2.41e-0666615IPR018200
DomainUSP_1

USP17L7 USP17L4 USP17L2 USP17L3 USP17L8

3.23e-0670615PS00972
DomainRav1p_C

DMXL2 DMXL1

1.05e-052612IPR022033
DomainRav1p_C

DMXL2 DMXL1

1.05e-052612PF12234
DomainPLAC

ADAMTS19 PCSK6 ADAMTS16

1.18e-0514613PF08686
DomainHABP4_PAI-RBP1

USP17L7 USP17L2 USP17L3

1.80e-0516613PF04774
DomainHABP4_PAIRBP1-bd

USP17L7 USP17L2 USP17L3

1.80e-0516613IPR006861
DomainPLAC

ADAMTS19 PCSK6 ADAMTS16

3.09e-0519613PS50900
DomainPLAC

ADAMTS19 PCSK6 ADAMTS16

3.09e-0519613IPR010909
DomainTSP_1

CCN6 ADAMTS19 ADAMTS16 ADAMTS20

5.31e-0563614PF00090
DomainADAM_spacer1

ADAMTS19 ADAMTS16 ADAMTS20

5.60e-0523613IPR010294
DomainADAM_spacer1

ADAMTS19 ADAMTS16 ADAMTS20

5.60e-0523613PF05986
DomainTSP1

CCN6 ADAMTS19 ADAMTS16 ADAMTS20

6.01e-0565614SM00209
DomainTSP1_rpt

CCN6 ADAMTS19 ADAMTS16 ADAMTS20

6.01e-0565614IPR000884
DomainTSP1

CCN6 ADAMTS19 ADAMTS16 ADAMTS20

6.01e-0565614PS50092
DomainPeptidase_M12B_ADAM-TS

ADAMTS19 ADAMTS16 ADAMTS20

6.39e-0524613IPR013273
DomainAnk_2

POTEB3 POTEM POTEG POTEI POTEH POTEC

7.11e-05215616PF12796
Domain-

POTEB3 POTEM POTEG POTEI POTEH POTEC

1.56e-042486161.25.40.20
DomainANK

POTEB3 POTEM POTEG POTEI POTEH POTEC

1.66e-04251616SM00248
DomainANK_REPEAT

POTEB3 POTEM POTEG POTEI POTEH POTEC

1.73e-04253616PS50088
DomainAnkyrin_rpt-contain_dom

POTEB3 POTEM POTEG POTEI POTEH POTEC

1.77e-04254616IPR020683
DomainANK_REP_REGION

POTEB3 POTEM POTEG POTEI POTEH POTEC

1.77e-04254616PS50297
DomainAnkyrin_rpt

POTEB3 POTEM POTEG POTEI POTEH POTEC

2.09e-04262616IPR002110
DomainPeptidase_M12B_N

ADAMTS19 ADAMTS16 ADAMTS20

2.79e-0439613IPR002870
DomainPep_M12B_propep

ADAMTS19 ADAMTS16 ADAMTS20

2.79e-0439613PF01562
DomainDISINTEGRIN_1

ADAMTS19 ADAMTS16 ADAMTS20

3.00e-0440613PS00427
DomainReprolysin

ADAMTS19 ADAMTS16 ADAMTS20

3.00e-0440613PF01421
DomainADAM_MEPRO

ADAMTS19 ADAMTS16 ADAMTS20

3.00e-0440613PS50215
DomainDISINTEGRIN_2

ADAMTS19 ADAMTS16 ADAMTS20

3.00e-0440613PS50214
DomainPeptidase_M12B

ADAMTS19 ADAMTS16 ADAMTS20

3.00e-0440613IPR001590
DomainDisintegrin_dom

ADAMTS19 ADAMTS16 ADAMTS20

3.23e-0441613IPR001762
DomainDAGK_acc

DGKE DGKD

4.64e-0410612PF00609
DomainDiacylglycerol_kin_accessory

DGKE DGKD

4.64e-0410612IPR000756
DomainDAGKa

DGKE DGKD

4.64e-0410612SM00045
Domain-

MAEA BAZ1B KMT2A RNF213 PHF14 SCAF11 RNF145

6.30e-044496173.30.40.10
DomainZnf_RING/FYVE/PHD

MAEA BAZ1B KMT2A RNF213 PHF14 SCAF11 RNF145

7.18e-04459617IPR013083
DomainC1_1

STAC2 DGKE DGKD

8.56e-0457613PF00130
DomainAnk

POTEM POTEG POTEI POTEH POTEC

8.85e-04228615PF00023
DomainDAGKc

DGKE DGKD

9.31e-0414612SM00046
DomainDiacylglycerol_kinase_cat_dom

DGKE DGKD

1.07e-0315612IPR001206
DomainDAGK_cat

DGKE DGKD

1.07e-0315612PF00781
DomainDAGK

DGKE DGKD

1.07e-0315612PS50146
DomainZF_DAG_PE_1

STAC2 DGKE DGKD

1.20e-0364613PS00479
DomainZF_DAG_PE_2

STAC2 DGKE DGKD

1.20e-0364613PS50081
DomainC1

STAC2 DGKE DGKD

1.25e-0365613SM00109
DomainPE/DAG-bd

STAC2 DGKE DGKD

1.31e-0366613IPR002219
DomainNAD/diacylglycerol_kinase

DGKE DGKD

1.38e-0317612IPR016064
DomainPHD

BAZ1B KMT2A PHF14

1.89e-0375613PF00628
DomainZnf_PHD-finger

BAZ1B KMT2A PHF14

2.20e-0379613IPR019787
DomainEPHD

KMT2A PHF14

2.32e-0322612PS51805
DomainMetalloPept_cat_dom

ADAMTS19 ADAMTS16 ADAMTS20

2.36e-0381613IPR024079
Domain-

ADAMTS19 ADAMTS16 ADAMTS20

2.36e-03816133.40.390.10
DomainPHD

BAZ1B KMT2A PHF14

3.08e-0389613SM00249
DomainRING

RNF144A BAZ1B RNF213 SCAF11 RNF145

3.17e-03305615SM00184
DomainZnf_PHD

BAZ1B KMT2A PHF14

3.28e-0391613IPR001965
DomainZF_PHD_2

BAZ1B KMT2A PHF14

3.71e-0395613PS50016
DomainZF_PHD_1

BAZ1B KMT2A PHF14

3.82e-0396613PS01359
DomainZINC_PROTEASE

ADAMTS19 ADAMTS16 ADAMTS20

4.04e-0398613PS00142
DomainZnf_RING

RNF144A BAZ1B RNF213 SCAF11 RNF145

4.20e-03326615IPR001841
DomainCYSTEINE_SWITCH

ADAMTS19 ADAMTS16

7.93e-0341612PS00546
DomainBROMODOMAIN_2

BAZ1B KMT2A

7.93e-0341612PS50014
PathwayREACTOME_RAS_PROCESSING

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

4.82e-0945446MM15671
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L7 USP17L4 HIF1A USP17L2 USP17L1 USP17L3 USP17L8

1.88e-06191447MM15289
PathwayREACTOME_DEUBIQUITINATION

USP17L7 USP17L4 HIF1A USP17L2 USP17L1 USP17L3 USP17L8

1.51e-05262447MM15286
PathwayREACTOME_UB_SPECIFIC_PROCESSING_PROTEASES

USP17L4 HIF1A USP17L2 USP17L1 USP17L3 USP17L8

5.95e-05221446M27578
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS19 ADAMTS16 ADAMTS20

2.40e-0439443M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS19 ADAMTS16 ADAMTS20

2.40e-0439443MM15165
PathwayREACTOME_DEUBIQUITINATION

USP17L4 HIF1A USP17L2 USP17L1 USP17L3 USP17L8

3.10e-04299446M27574
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

4.31e-04318446MM15278
PathwayWP_HYPOXIADEPENDENT_DIFFERENTIATION_OF_MYOBLASTS

MYF5 HIF1A

7.27e-0413442MM15894
PathwayREACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION

USP17L7 ADAMTS19 USP17L4 HIF1A USP17L2 USP17L1 RNF144A ADAMTS16 USP17L3 ADAMTS20 USP17L8 FBXL5

8.45e-0413894412MM15307
PathwayWP_HYPOXIADEPENDENT_SELFRENEWAL_OF_MYOBLASTS

MYF5 HIF1A

8.46e-0414442MM15832
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS19 ADAMTS16 ADAMTS20

1.23e-0368443M27303
Pubmed

High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

5.23e-151062624207026
Pubmed

Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

2.29e-141262624695638
Pubmed

ES cell neural differentiation reveals a substantial number of novel ESTs.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

7.43e-141462611793228
Pubmed

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

6.67e-131962628067227
Pubmed

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.33e-12216268622927
Pubmed

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.33e-122162614583620
Pubmed

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.33e-122162611468161
Pubmed

The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.33e-12216268756639
Pubmed

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.33e-122162612447969
Pubmed

DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.33e-122162618980247
Pubmed

JAK2 is required for induction of the murine DUB-1 gene.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.83e-12226269154835
Pubmed

DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.29e-12246268995226
Pubmed

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

4.32e-122562621115691
Pubmed

Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

5.60e-122662635816173
Pubmed

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.15e-112962632527007
Pubmed

Cdc25A and Dub3 in a high-stakes balancing act.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

2.67e-113362620228807
Pubmed

The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462620403174
Pubmed

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462617109758
Pubmed

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462620388806
Pubmed

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462614699124
Pubmed

Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462620715989
Pubmed

Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-11346269806828
Pubmed

The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462620368735
Pubmed

The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462615780755
Pubmed

USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462619188362
Pubmed

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462611941478
Pubmed

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462610936051
Pubmed

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.24e-113462621448158
Pubmed

Cytokine-regulated protein degradation by the ubiquitination system.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.90e-113562616611142
Pubmed

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.90e-113562621239494
Pubmed

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

4.68e-113662620147298
Pubmed

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

5.57e-113762620228808
Pubmed

Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.

POTEM POTEG POTEH POTEC

1.37e-10662417171436
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

3.74e-105062631806660
Pubmed

Human and mouse proteases: a comparative genomic approach.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

7.32e-098162612838346
Pubmed

Identification and characterization of TSAP, a novel gene specifically expressed in testis during spermatogenesis.

POTEM POTEH POTEC

2.16e-08462317342726
Pubmed

DNA sequence and analysis of human chromosome 8.

USP17L7 USP17L4 USP17L1 USP17L3 USP17L8

2.46e-084862516421571
Pubmed

Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths.

POTEB3 POTEG POTEH

1.88e-07762315276201
Pubmed

POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.

POTEB3 POTEH POTEC

3.00e-07862312475935
Pubmed

The Vertebrate Genome Annotation browser 10 years on.

POTEB3 POTEM POTEG POTEI POTEH POTEC

4.78e-0716362624316575
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEM POTEG POTEI

2.42e-061562316824795
Pubmed

Exogenous proline stimulates type I collagen and HIF-1α expression and the process is attenuated by glutamine in human skin fibroblasts.

HIF1A COL1A1

3.13e-06262228526934
Pubmed

MLL1 promotes myogenesis by epigenetically regulating Myf5.

MYF5 KMT2A

3.13e-06262231840352
Pubmed

Hypoxia inducible factor 1 alpha down-regulates type i collagen through Sp3 transcription factor in human chondrocytes.

HIF1A COL1A1

9.37e-06362227521280
Pubmed

Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia.

HIF1A KMT2A

9.37e-06362228756022
Pubmed

Effects of individual control of pH and hypoxia in chondrocyte culture.

HIF1A COL1A1

9.37e-06362219813243
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

CCN6 ADAMTS19 ADAMTS16 ADAMTS20

1.01e-057562420637190
Pubmed

Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated transformation.

KMT2A COL1A1

1.87e-05462225456127
Pubmed

FBXL5 modulates HIF-1α transcriptional activity by degradation of CITED2.

HIF1A FBXL5

1.87e-05462225956243
Pubmed

Indomethacin-induced intestinal epithelial cell damage is mediated by pVHL activation through the degradation of collagen I and HIF-1α.

HIF1A COL1A1

1.87e-05462226551465
Pubmed

ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.

ADAMTS19 ADAMTS16

1.87e-05462228088271
Pubmed

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.

HIF1A KMT2A

1.87e-05462226642852
Pubmed

Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein.

MYF5 HIF1A

3.12e-05562226468276
Pubmed

Personalized copy number and segmental duplication maps using next-generation sequencing.

POTEB3 USP17L2

3.12e-05562219718026
Pubmed

The efficiency of murine MLL-ENL-driven leukemia initiation changes with age and peaks during neonatal development.

KMT2A COL1A1

3.12e-05562231405949
Pubmed

Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.

KMT2A COL1A1

4.67e-05662225866973
Pubmed

The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.

POLR1A BAZ1B

4.67e-05662216514417
Pubmed

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.

HIF1A COL1A1

4.67e-05662233951475
Pubmed

Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.

HIF1A CIDEC

4.67e-05662232958928
Pubmed

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis.

MYF5 KMT2A

6.53e-0576229724755
Pubmed

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

ADAMTS19 ADAMTS16

6.53e-05762211867212
Pubmed

Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.

MYF5 COL1A1

6.53e-05762223666760
Pubmed

The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.

MYF5 COL1A1

6.53e-05762225087979
Pubmed

The actin regulator N-WASp is required for muscle-cell fusion in mice.

MYF5 WASL

6.53e-05762222736793
Pubmed

The Lin28/let-7 axis regulates glucose metabolism.

MYF5 COL1A1

6.53e-05762221962509
Pubmed

MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells.

MYF5 COL1A1

6.53e-05762221425413
Pubmed

The involvement of cytokine-like 1 (Cytl1) in chondrogenesis and cartilage metabolism.

HIF1A COL1A1

8.69e-05862232736681
Pubmed

Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer.

CCN6 HIF1A

8.69e-05862220403915
Pubmed

Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.

ADAMTS19 COL1A1

1.12e-04962231844321
Pubmed

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

POTEM POTEI

1.12e-04962216364570
Pubmed

Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice.

HIF1A COL1A1

1.39e-041062235021856
Pubmed

TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis.

MYF5 COL1A1

1.39e-041062220193675
Pubmed

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.

DGKE DGKD

1.70e-041162217021016
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 EPB41L4A USP17L8

1.94e-0467462737196079
Pubmed

Noggin Overexpression Impairs the Development of Muscles, Tendons, and Aponeurosis in Soft Palates by Disrupting BMP-Smad and Shh-Gli1 Signaling.

MYF5 COL1A1

2.41e-041362234557486
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DMXL2 RNF144A ADAMTS16 RNF213 PHF14 DGKD

2.47e-0449362615368895
Pubmed

Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.

ADAMTS16 COL1A1

3.23e-041562238018454
Pubmed

A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development.

MYF5 COL1A1

3.69e-041662222438570
Pubmed

The transcription factors Foxf1 and Foxf2 integrate the SHH, HGF and TGFβ signaling pathways to drive tongue organogenesis.

MYF5 COL1A1

3.69e-041662236227576
Pubmed

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.

MYF5 CIDEC

4.18e-041762226963625
Pubmed

SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice.

HIF1A COL1A1

4.18e-041762222318228
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

WASL POLR1A KMT2A SCAF11

4.73e-0420262424639526
Pubmed

PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis.

MYF5 COL1A1

5.24e-041962228049691
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF224 ZNF112

5.82e-042062212743021
Pubmed

Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.

RNF144A FHOD3

6.42e-042162220195266
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

BAZ1B KMT2A PHF14

8.40e-0410362332744500
Pubmed

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development.

MYF5 COL1A1

9.89e-042662219590010
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

LENG8 BAZ1B KMT2A SCAF11

1.06e-0325162431076518
Pubmed

Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.

DMXL2 DMXL1

1.07e-032762226442671
Pubmed

Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.

HIF1A COL1A1

1.15e-032862228847650
Pubmed

Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature.

MYF5 COL1A1

1.15e-032862231719045
Pubmed

Maternal diabetes alters transcriptional programs in the developing embryo.

HIF1A BAZ1B

1.50e-033262219538749
Pubmed

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.

MYF5 COL1A1

1.59e-033362218424556
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

HIF1A PCSK6 BAZ1B KMT2A PHF14 RNF145

1.64e-0370962622988430
InteractionPOTEG interactions

POTEG POTEH POTEC

4.89e-0612583int:POTEG
InteractionPOTEC interactions

POTEB3 POTEG POTEC

6.34e-0613583int:POTEC
InteractionPOTEH interactions

POTEG POTEH

8.14e-062582int:POTEH
InteractionPOTED interactions

POTEB3 POTEC

4.87e-054582int:POTED
InteractionADAMTS19 interactions

ADAMTS19 ADAMTS16

8.10e-055582int:ADAMTS19
Cytoband8p23.1

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

6.80e-081546268p23.1
CytobandEnsembl 112 genes in cytogenetic band chr8p23

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

7.96e-07234626chr8p23
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEM POTEG POTEI POTEH POTEC

1.08e-1013465685
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS19 ADAMTS16 ADAMTS20

1.45e-051946350
GeneFamilyEF-hand domain containing|Diacylglycerol kinases

DGKE DGKD

2.81e-04104621178
GeneFamilyAnkyrin repeat domain containing

POTEM POTEG POTEI POTEH POTEC

3.61e-04242465403
GeneFamilyPHD finger proteins

BAZ1B KMT2A PHF14

1.55e-039046388
GeneFamilyRing finger proteins

RNF144A RNF213 SCAF11 RNF145

5.18e-0327546458
CoexpressionMADAN_DPPA4_TARGETS

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

5.02e-0886616MM1312
CoexpressionGRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

2.44e-07112616MM1095
CoexpressionGERY_CEBP_TARGETS

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

1.98e-06160616MM1155
CoexpressionGSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_CD4_TCELL_UP

DMXL2 DDX60 TPPP CD163 FBXL5

4.93e-05171615M6746
CoexpressionDARWICHE_PAPILLOMA_PROGRESSION_RISK

SLC38A10 POTEM POTEH POTEC

6.36e-0592614MM503
CoexpressionNOTCH_DN.V1_UP

MYF5 EFNA3 TPPP DGKE ZNF112

7.35e-05186615M2789
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

MYF5 HIF1A USP17L2 POTEM POTEH POTEC

8.23e-05309616MM1244
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_top-relative-expression-ranked_1000

WASL DMXL2 PCSK6 TAFA1 ADAMTS16 RNF213 SCAF11 HERC1 RNF145 DMXL1

1.23e-057705110gudmap_developingGonad_P2_ovary_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000

WASL DMXL2 PCSK6 ADAMTS16 RNF213 DGKD SCAF11 HERC1 RNF145 DMXL1

1.35e-057785110gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#5_top-relative-expression-ranked_1000

HIF1A ADAMTS16 RNF213 HERC1 DMXL1

1.99e-05138515gudmap_developingGonad_e12.5_epididymis_k5_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_500

ADAMTS16 HERC1 RNF145 DMXL1

2.02e-0567514gudmap_developingGonad_e18.5_epididymis_500_k3
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_500

DMXL2 PCSK6 ADAMTS16 RNF213 HERC1 RNF145 DMXL1

3.67e-05387517gudmap_developingGonad_e16.5_ovary_500
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_500

ADAMTS16 SCAF11 LTBP2 HERC1 RNF145 DMXL1 COL1A1

4.82e-05404517gudmap_developingGonad_e18.5_epididymis_500
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_k-means-cluster#4_top-relative-expression-ranked_1000

DMXL2 ADAMTS16 RNF213 HERC1 DMXL1

5.11e-05168515gudmap_developingGonad_P2_ovary_1000_k4
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000

DMXL2 HIF1A ADAMTS16 TPPP RNF213 DGKD HERC1 RNF145 DMXL1

8.51e-05776519gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

DMXL2 HIF1A PCSK6 ADAMTS16 RNF213 SCAF11 HERC1 RNF145 DMXL1

1.02e-04795519gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#3_top-relative-expression-ranked_500

ADAMTS16 RNF213 HERC1 DMXL1

1.57e-04113514gudmap_developingGonad_e16.5_ovary_500_k3
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#3_top-relative-expression-ranked_500

ADAMTS16 HERC1 DMXL1

1.72e-0445513gudmap_developingGonad_e16.5_epididymis_500_k3
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#5_top-relative-expression-ranked_1000

HIF1A ADAMTS16 RNF213 HERC1 DMXL1

1.78e-04219515gudmap_developingGonad_e16.5_ovary_1000_k5
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#5_top-relative-expression-ranked_1000

DMXL2 ADAMTS16 RNF213 HERC1 DMXL1

2.23e-04230515gudmap_developingGonad_e18.5_ovary_1000_k5
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_1000

DMXL2 HIF1A RNF213 HERC1 DMXL1

2.37e-04233515gudmap_developingGonad_e12.5_ovary_k5_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#1_top-relative-expression-ranked_500

DMXL2 ADAMTS16 HERC1 DMXL1

3.01e-04134514gudmap_developingGonad_e18.5_ovary_500_k1
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_500

DMXL2 PCSK6 ADAMTS16 HERC1 RNF145 DMXL1

3.18e-04387516gudmap_developingGonad_e18.5_ovary_500
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500

HIF1A ADAMTS16 SCAF11 HERC1 RNF145 DMXL1

3.94e-04403516gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlasgeo_heart_top-relative-expression-ranked_1000_k-means-cluster#5

B3GALT2 MYLK3 UNC45B CIDEC TPPP FHOD3

5.15e-04424516geo_heart_1000_K5
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_top-relative-expression-ranked_200

LTBP2 RNF145 DMXL1 COL1A1

5.49e-04157514gudmap_developingGonad_P2_epididymis_200
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_top-relative-expression-ranked_1000

POLR1A ADAMTS16 SCAF11 LTBP2 HERC1 RNF145 DMXL1 COL1A1

5.79e-04797518gudmap_developingGonad_P2_epididymis_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#4_top-relative-expression-ranked_100

RNF145 DMXL1

5.82e-0415512gudmap_developingGonad_e18.5_epididymis_100_k4
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000

DMXL2 HIF1A RNF213 SCAF11 HERC1 RNF145 RFX3 DMXL1

6.13e-04804518gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

HIF1A POLR1A ADAMTS16 RNF213 SCAF11 HERC1 RNF145 DMXL1

6.24e-04806518gudmap_developingGonad_e12.5_epididymis_1000
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

HIF1A DDX60 RNF213 RFX3 DMXL1

7.69e-06195625b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KMT2A RNF213 DGKE HERC1 RFX3

8.08e-0619762557ebd552f10d6278623b52a3d484d4b91ae1d028
Diseasecongenital heart disease (implicated_via_orthology)

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 KMT2A USP17L8

4.54e-1169547DOID:1682 (implicated_via_orthology)
Diseaseprimary ovarian insufficiency (implicated_via_orthology)

USP17L7 USP17L4 USP17L2 USP17L1 USP17L3 USP17L8

2.50e-1046546DOID:5426 (implicated_via_orthology)
Diseasebladder neck obstruction (biomarker_via_orthology)

HIF1A COL1A1

1.17e-049542DOID:13948 (biomarker_via_orthology)
DiseaseVaricose veins

STAC2 PCSK6 KMT2A FHOD3

4.35e-04193544HP_0002619
Diseaseresponse to perphenazine

RNF144A FHOD3

1.04e-0326542GO_0097334
Diseasesevere acute respiratory syndrome, COVID-19

PCSK6 TAFA1 OSBPL11 PHF14 LTBP2

1.34e-03447545EFO_0000694, MONDO_0100096

Protein segments in the cluster

PeptideGeneStartEntry
IKWDMSAENARCKVC

BAZ1B

1176

Q9UIG0
KCVWQCKTSVSVHLM

DMXL2

161

Q8TDJ6
CIWHCKTASQVHLMK

DMXL1

161

Q9Y485
LWCHRIGRKCETKFM

ADAMTS16

541

Q8TE57
CMHLWCTSTEKLHKG

ADAMTS20

506

P59510
QEMQHVICTGLWCKV

ADAMTS19

581

Q8TE59
HCLMWACKACKRKST

MYF5

66

P13349
WCHDNKSRLRKMKSC

MAEA

181

Q7L5Y9
HRWCCNKKNAVVMDQ

KIR2DL3

266

P43628
TMNIKSATWKVLHCT

HIF1A

181

Q16665
VAVLKKSLCMVKCHW

LENG8

576

Q96PV6
AHQNRVMTCVWCNKK

HERC1

3426

Q15751
MVGLTACLKAWKEHC

DDX60

641

Q8IY21
KKWTAVPSQHMCVAA

PCSK6

491

P29122
GRWKACNTCASHLMV

OR5A1

236

Q8NGJ0
SCRMSATQCLKHEWL

MYLK3

756

Q32MK0
WSSQKMDHILICCVC

PHF14

311

O94880
KACRMEFCSTCKASW

RNF144A

136

P50876
MKTLRSKMGKWCCHC

POTEB3

91

A0JP26
RRHCCFAKMTWNAKR

B3GALT2

6

O43825
KWKMLWITSCVCQRN

CCN6

326

O95389
KACTSICQWVRAMHK

DNAH1

3031

Q9P2D7
WKCLRMKVFVCCAST

EFNA3

156

P52797
CQMERRCKASWDHLK

FHOD3

1166

Q2V2M9
CLSWMSLKWTQAVHC

BCE1

51

O60756
IHMDICWKKVTNDVC

LTBP2

1581

Q14767
HKTNIKMRCEFLACW

CSAG2

26

Q9Y5P2
RCLWCKAMVHTSCKE

DGKD

266

Q16760
MQCGKCDRWVHSKCE

KMT2A

1586

Q03164
CRCSQVSMKWSQLTK

FBXL5

226

Q9UKA1
CIWCQKTVHDECMKN

DGKE

156

P52429
MKCNGKESRIWQCHS

CD163

786

Q86VB7
RSKTACKHLWKCSVE

EPB41L4A

276

Q9HCS5
HVFCMTCILKWAETL

SCAF11

61

Q99590
CSWMTHQSCMFLVKS

SLC38A10

46

Q9HBR0
ECTERKMCVNAHVWT

OSBPL11

521

Q9BXB4
MKTLRSKMGKWCCHC

POTEC

91

B2RU33
WMCATGNKIKTTRIH

TAFA1

116

Q7Z5A9
WKAHMNAKRCPHCKT

POLR1A

196

O95602
ITLCKHESILKWMCN

RFX3

416

P48380
MKTLRSKMGKWCCHC

POTEI

91

P0CG38
THQCWKALLMKKCNG

PPA2

271

Q9H2U2
HCCGAKRIMKEAFRW

CIDEC

176

Q96AQ7
ARTCRDLKMCHSDWK

COL1A1

1256

P02452
RKSVVHCSKIWSCRK

RNF213

4731

Q63HN8
KCCMLCTMQAHITWA

USP17L3

121

A6NCW0
AKQCRKWLCNMSIDT

UNC45B

511

Q8IWX7
KCCMLCTMQAHITWA

USP17L4

121

A6NCW7
CKMCKVSVHLWCSEE

STAC2

141

Q6ZMT1
KCCMLCTMQAHITWA

USP17L1

121

Q7RTZ2
CVHSHWTVCGQKMSK

MARS2

336

Q96GW9
ISMKNHFCKCDSVSW

ZNF112

201

Q9UJU3
MHGKNWSKLCKDCQV

TPPP

71

O94811
KCCMFCTMQAHITWA

USP17L7

121

P0C7H9
KCCMLCTMQAHITWA

USP17L8

121

P0C7I0
VRGIQVRMKWCATCH

ZDHHC8

96

Q9ULC8
ADRNCMWSKKCSGVA

WASL

51

O00401
QRVHMGEKTWKCREC

ZNF224

671

Q9NZL3
LCSCVMKTKQIWLFS

RNF145

136

Q96MT1
MKTLRSKMGKWCCHC

POTEG

91

Q6S5H5
MKTLRSKMGKWCCHC

POTEH

91

Q6S545
MKTLRSKMGKWCCHC

POTEM

91

A6NI47
KCCMLCTMQAHITWA

USP17L2

121

Q6R6M4