Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	establishment of planar polarity	TTC8 DVL1 DVL2 PTK7	2.07e-05	44	76	4	GO:0001736
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity involved in neural tube closure	DVL1 DVL2 PTK7	2.12e-05	15	76	3	GO:0090178
GeneOntologyBiologicalProcess	establishment of tissue polarity	TTC8 DVL1 DVL2 PTK7	2.26e-05	45	76	4	GO:0007164
GeneOntologyBiologicalProcess	establishment of planar polarity involved in neural tube closure	DVL1 DVL2 PTK7	2.60e-05	16	76	3	GO:0090177
GeneOntologyBiologicalProcess	establishment of planar polarity of embryonic epithelium	DVL1 DVL2 PTK7	3.77e-05	18	76	3	GO:0042249
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity	DVL1 DVL2 PTK7	4.46e-05	19	76	3	GO:0090175
GeneOntologyBiologicalProcess	convergent extension	DVL1 DVL2 PTK7	4.46e-05	19	76	3	GO:0060026
GeneOntologyBiologicalProcess	neural plate elongation	DVL1 DVL2	8.00e-05	4	76	2	GO:0014022
GeneOntologyBiologicalProcess	convergent extension involved in neural plate elongation	DVL1 DVL2	8.00e-05	4	76	2	GO:0022007
GeneOntologyBiologicalProcess	morphogenesis of a polarized epithelium	TTC8 DVL1 DVL2 PTK7	1.53e-04	73	76	4	GO:0001738
GeneOntologyBiologicalProcess	cochlea morphogenesis	DVL1 DVL2 PTK7	1.64e-04	29	76	3	GO:0090103
GeneOntologyBiologicalProcess	intermembrane lipid transfer	PITPNM2 OSBPL8 PRELID3B	2.65e-04	34	76	3	GO:0120009
GeneOntologyBiologicalProcess	convergent extension involved in organogenesis	DVL1 DVL2	2.78e-04	7	76	2	GO:0060029
GeneOntologyBiologicalProcess	positive regulation of neuron projection arborization	DVL1 DVL2	3.70e-04	8	76	2	GO:0150012
Domain	Dishevelled_fam	DVL1P1 DVL1 DVL2	2.48e-07	4	75	3	IPR008339
Domain	Dishevelled	DVL1P1 DVL1 DVL2	2.48e-07	4	75	3	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1 DVL2	2.48e-07	4	75	3	IPR003351
Domain	DIX	DVL1P1 DVL1 DVL2	2.15e-06	7	75	3	PF00778
Domain	DIX	DVL1P1 DVL1 DVL2	2.15e-06	7	75	3	IPR001158
Domain	DIX	DVL1P1 DVL1 DVL2	2.15e-06	7	75	3	PS50841
Domain	DAX	DVL1P1 DVL1 DVL2	2.15e-06	7	75	3	SM00021
Domain	DVL-1	DVL1P1 DVL1	1.59e-05	2	75	2	IPR008340
Domain	Bromodomain	BPTF BRPF1 ZMYND8 ATAD2	1.60e-05	38	75	4	PF00439
Domain	BROMODOMAIN_2	BPTF BRPF1 ZMYND8 ATAD2	2.17e-05	41	75	4	PS50014
Domain	BROMO	BPTF BRPF1 ZMYND8 ATAD2	2.39e-05	42	75	4	SM00297
Domain	Bromodomain	BPTF BRPF1 ZMYND8 ATAD2	2.39e-05	42	75	4	IPR001487
Domain	-	BPTF BRPF1 ZMYND8 ATAD2	2.39e-05	42	75	4	1.20.920.10
Domain	Spectrin_alpha_SH3	SORBS3 BCAR1 TP53BP2	2.73e-05	15	75	3	IPR013315
Domain	Dsh_C	DVL1 DVL2	4.76e-05	3	75	2	PF12316
Domain	Dishevelled_C-dom	DVL1 DVL2	4.76e-05	3	75	2	IPR024580
Domain	PWWP	BRPF1 ZMYND8 DNMT3A	6.75e-05	20	75	3	SM00293
Domain	DEP	DVL1P1 DVL1 DVL2	9.07e-05	22	75	3	PF00610
Domain	DEP	DVL1P1 DVL1 DVL2	9.07e-05	22	75	3	PS50186
Domain	DEP	DVL1P1 DVL1 DVL2	9.07e-05	22	75	3	SM00049
Domain	Dsh/Dvl-rel	DVL1 DVL2	9.50e-05	4	75	2	IPR015506
Domain	DEP_dom	DVL1P1 DVL1 DVL2	1.04e-04	23	75	3	IPR000591
Domain	PWWP	BRPF1 ZMYND8 DNMT3A	1.04e-04	23	75	3	PF00855
Domain	PWWP_dom	BRPF1 ZMYND8 DNMT3A	1.04e-04	23	75	3	IPR000313
Domain	PWWP	BRPF1 ZMYND8 DNMT3A	1.18e-04	24	75	3	PS50812
Domain	BROMODOMAIN_1	BPTF BRPF1 ATAD2	4.38e-04	37	75	3	PS00633
Domain	rSAM	TYW1B CDK5RAP1	5.62e-04	9	75	2	IPR007197
Domain	Radical_SAM	TYW1B CDK5RAP1	5.62e-04	9	75	2	PF04055
Domain	Ubiquitin-rel_dom	USP24 DVL1 DVL2 NPLOC4 TP53BP2	8.69e-04	184	75	5	IPR029071
Domain	Zinc_finger_PHD-type_CS	BPTF BRPF1 ZMYND8	2.27e-03	65	75	3	IPR019786
Domain	PDZ	DVL1P1 MAST4 DVL1 DVL2	2.50e-03	141	75	4	PF00595
Domain	Znf_FYVE_PHD	BPTF BRPF1 ZMYND8 DNMT3A	2.90e-03	147	75	4	IPR011011
Domain	PDZ	DVL1P1 MAST4 DVL1 DVL2	2.98e-03	148	75	4	SM00228
Domain	PDZ	DVL1P1 MAST4 DVL1 DVL2	3.20e-03	151	75	4	PS50106
Domain	PDZ	DVL1P1 MAST4 DVL1 DVL2	3.27e-03	152	75	4	IPR001478
Domain	Znf_PHD-finger	BPTF BRPF1 ZMYND8	3.95e-03	79	75	3	IPR019787
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1 DVL2	4.33e-08	4	78	3	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1 DVL2	4.33e-08	4	78	3	9192851
Pubmed	All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.	DVL1 DVL2 DACT2	6.03e-07	8	78	3	21718540
Pubmed	Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.	SLC30A5 SQLE OSBPL8 NDUFA10 NPLOC4 LACTB PTK7	1.03e-06	235	78	7	32614325
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PPP1R10 BPTF GTF2E1 BRPF1 DOT1L ATAD2 MGA SENP7 DNMT3A NCBP3	1.07e-06	608	78	10	36089195
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	TTLL12 BPTF GTF2E1 ZMYND8 DVL2 OSBPL8 HSD17B4 TP53BP2 NCBP3	1.15e-06	472	78	9	38943005
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PPP1R10 BPTF GTF2E1 ZMYND8 DDX42 CDK11A MGA	3.54e-06	283	78	7	30585729
Pubmed	DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.	DOT1L DNMT3A	4.97e-06	2	78	2	27335278
Pubmed	Wnt-mediated relocalization of dishevelled proteins.	DVL1 DVL2	4.97e-06	2	78	2	8856345
Pubmed	The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis.	DDX42 TP53BP2	4.97e-06	2	78	2	19377511
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	4.97e-06	2	78	2	8644734
Pubmed	Epigenetic Reprogramming of Lineage-Committed Human Mammary Epithelial Cells Requires DNMT3A and Loss of DOT1L.	DOT1L DNMT3A	4.97e-06	2	78	2	28781076
Pubmed	The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.	DVL1 DVL2 PTK7	5.95e-06	16	78	3	22771245
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	WDR3 PPP1R10 BPTF ZMYND8 DDX42 PCID2 NCBP3	1.19e-05	341	78	7	32971831
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	WDR3 PPP1R10 ZMYND8 MGA TADA3	1.33e-05	134	78	5	25452129
Pubmed	Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways.	DVL1 DVL2	1.49e-05	3	78	2	15852005
Pubmed	Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.	DVL1 DVL2	1.49e-05	3	78	2	18093802
Pubmed	DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.	DVL1 DVL2	1.49e-05	3	78	2	32900645
Pubmed	Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.	DVL1 DVL2	1.49e-05	3	78	2	27744318
Pubmed	The DIX domain targets dishevelled to actin stress fibres and vesicular membranes.	DVL1P1 DVL2	1.49e-05	3	78	2	12384700
Pubmed	Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.	DVL1 DVL2	1.49e-05	3	78	2	27086035
Pubmed	Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.	DVL1 DVL2	1.49e-05	3	78	2	20224554
Pubmed	Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway.	DVL1 DVL2	1.49e-05	3	78	2	10409711
Pubmed	Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.	DVL1 DVL2	1.49e-05	3	78	2	21092292
Pubmed	Mechanism of activation of the Formin protein Daam1.	DVL1 DVL2	1.49e-05	3	78	2	18162551
Pubmed	Genomic organization of mouse Dishevelled genes.	DVL1 DVL2	1.49e-05	3	78	2	8973355
Pubmed	Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.	DVL1 DVL2	1.49e-05	3	78	2	18692936
Pubmed	Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.	DVL1 DVL2	1.49e-05	3	78	2	16116426
Pubmed	beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.	DVL1 DVL2	1.49e-05	3	78	2	11742073
Pubmed	Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.	DVL1 DVL2	1.49e-05	3	78	2	23437169
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TTLL12 TRAF3IP2 SLC30A5 NOA1 CDK5RAP1 HSD17B4 CNOT4 NPLOC4 PTK7	1.52e-05	650	78	9	38777146
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	BPTF ZNF274 ZMYND8 CDK5RAP2 MGA SENP7 NCBP3	1.78e-05	363	78	7	14691545
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	WDR3 SQLE ZMYND8 DDX42 USP24 SECISBP2 CDK5RAP2 DOT1L MAPK10 CNOT4 NPLOC4 DNMT3A	2.01e-05	1242	78	12	30973865
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	BPTF BRPF1 ZMYND8 ATAD2	2.52e-05	75	78	4	25593309
Pubmed	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.	DVL1 DVL2	2.97e-05	4	78	2	24643799
Pubmed	Molecular basis of Wnt activation via the DIX domain protein Ccd1.	DVL1 DVL2	2.97e-05	4	78	2	21189423
Pubmed	Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.	DVL1 DVL2	2.97e-05	4	78	2	19625296
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	2.97e-05	4	78	2	20639201
Pubmed	Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.	DVL1 DVL2	2.97e-05	4	78	2	16571627
Pubmed	Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.	DVL1 DVL2	2.97e-05	4	78	2	12533515
Pubmed	Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.	DVL1 DVL2	2.97e-05	4	78	2	25043421
Pubmed	Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18.	ARSB CSF1R	2.97e-05	4	78	2	8094988
Pubmed	Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.	DVL1 DVL2	2.97e-05	4	78	2	19465938
Pubmed	Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.	DVL1 DVL2	2.97e-05	4	78	2	23371553
Pubmed	Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.	DVL1 DVL2	2.97e-05	4	78	2	18772438
Pubmed	DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.	DVL1 DVL2	2.97e-05	4	78	2	25557784
Pubmed	Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.	DVL1 DVL2	2.97e-05	4	78	2	17593335
Pubmed	Dishevelled promotes Wnt receptor degradation through recruitment of ZNRF3/RNF43 E3 ubiquitin ligases.	DVL1 DVL2	2.97e-05	4	78	2	25891077
Pubmed	The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors.	DVL1 DVL2	2.97e-05	4	78	2	27599467
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZMYND8 USP24 DVL1 DVL2 NDUFA10 MGA TP53BP2	4.37e-05	418	78	7	34709266
Pubmed	PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation.	DVL2 PTK7	4.94e-05	5	78	2	19439496
Pubmed	Identification of a common protein association region in the neuronal Cdk5 activator.	CDK5RAP1 CDK5RAP2	4.94e-05	5	78	2	10915792
Pubmed	Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.	DVL1 DVL2	4.94e-05	5	78	2	15456783
Pubmed	CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.	DVL1 DVL2	4.94e-05	5	78	2	24469800
Pubmed	The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.	DVL1 DVL2	4.94e-05	5	78	2	22826439
Pubmed	Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor.	CDK5RAP1 CDK5RAP2	4.94e-05	5	78	2	11882646
Pubmed	Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation.	DVL1 DVL2	4.94e-05	5	78	2	21262972
Pubmed	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.	DVL1 DVL2	4.94e-05	5	78	2	25424568
Pubmed	Cloning of three novel neuronal Cdk5 activator binding proteins.	CDK5RAP1 CDK5RAP2	4.94e-05	5	78	2	10721722
Pubmed	Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.	DVL1 DVL2	4.94e-05	5	78	2	11779461
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	WDR3 PPP1R10 BPTF ZMYND8 DDX42 CDK11A NDUFA10 MGA TADA3 NCBP3	5.36e-05	954	78	10	36373674
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BPTF ERCC5 BRPF1 ZMYND8 SORBS3 USP24 CDK11A ATAD2 CCNY	5.92e-05	774	78	9	15302935
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	DDX42 DNAI3 PCID2	6.74e-05	35	78	3	24515614
Pubmed	WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.	USP24 DVL1 DVL2 CDK5RAP1	6.92e-05	97	78	4	25071155
Pubmed	Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.	DVL1 DVL2	7.40e-05	6	78	2	34139860
Pubmed	Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.	DVL1 DVL2	7.40e-05	6	78	2	32579954
Pubmed	Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.	DVL1 DVL2	7.40e-05	6	78	2	21880741
Pubmed	SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.	DVL1 DVL2	7.40e-05	6	78	2	20439735
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PITPNM2 UVSSA OSBPL8 NPLOC4	8.74e-05	103	78	4	10819331
Pubmed	Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.	DVL1 DVL2	1.04e-04	7	78	2	10806215
Pubmed	Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.	DVL1 DVL2	1.04e-04	7	78	2	19008950
Pubmed	Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.	DVL1 DVL2	1.04e-04	7	78	2	17005174
Pubmed	USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling.	DVL1 DVL2	1.04e-04	7	78	2	33786993
Pubmed	Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.	DVL1 DVL2	1.04e-04	7	78	2	10330403
Pubmed	The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.	DVL1 DVL2	1.04e-04	7	78	2	15262978
Pubmed	Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.	DVL1 DVL2	1.04e-04	7	78	2	22841628
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	WDR3 MAST4 BRPF1 DVL2 HSD17B4 MGA CNOT4 PCID2 TP53BP2	1.24e-04	853	78	9	28718761
Pubmed	Identification of APBB1 as a substrate for anaplastic lymphoma kinase.	DVL1 DVL2 PTK7	1.35e-04	44	78	3	39115278
Pubmed	Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.	DVL1 DVL2	1.38e-04	8	78	2	15454084
Pubmed	Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.	DVL1 DVL2	1.38e-04	8	78	2	22773187
Pubmed	M-CSF induces the stable interaction of cFms with alphaVbeta3 integrin in osteoclasts.	CSF1R BCAR1	1.38e-04	8	78	2	16600665
Pubmed	Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.	DVL1 DVL2	1.38e-04	8	78	2	12165471
Pubmed	A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).	DVL1P1 DVL1	1.38e-04	8	78	2	19643732
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	DVL1 DVL2	1.38e-04	8	78	2	19388021
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	WDR91 SLC30A5 TYW1B FIG4 OSBPL8 ATP6V1F HPS3	1.40e-04	504	78	7	34432599
Pubmed	RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.	DVL1 DVL2	1.77e-04	9	78	2	32965059
Pubmed	The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.	DVL2 DACT2	1.77e-04	9	78	2	25825496
Pubmed	Expression of planar cell polarity genes during development of the mouse CNS.	DVL1 DVL2	1.77e-04	9	78	2	16487141
Pubmed	Regulation of the Wnt signaling pathway by disabled-2 (Dab2).	DVL1 DVL2	1.77e-04	9	78	2	12805222
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	BPTF ARSB ZNF460 BRPF1 ZMYND8 DVL2 MGA TADA3 PCID2 SENP7	1.94e-04	1116	78	10	31753913
Pubmed	Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.	DVL1 DVL2	2.21e-04	10	78	2	15143170
Pubmed	Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.	DVL1 DVL2	2.21e-04	10	78	2	15637299
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	PPP1R10 BPTF USP24 DVL1 DOT1L MGA TP53BP2	2.36e-04	549	78	7	38280479
Pubmed	Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.	DVL1 DVL2	2.70e-04	11	78	2	10644691
Pubmed	Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.	DVL1 DVL2	3.23e-04	12	78	2	12421720
Pubmed	Microtubules enable the planar cell polarity of airway cilia.	DVL1 DVL2	3.23e-04	12	78	2	23122850
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	WDR3 PPP1R10 ZNF460 SQLE DDX42 OSBPL8 MGA PCID2 CCNY PTK7	3.52e-04	1203	78	10	29180619
Pubmed	Functional proteomics mapping of a human signaling pathway.	PPP1R10 MAST4 ZMYND8 SECISBP2 IL1RAP MGA TP53BP2	3.68e-04	591	78	7	15231748
Pubmed	Analysis of BCL6-interacting proteins by tandem mass spectrometry.	ERCC5 ZMYND8 SENP7	3.73e-04	62	78	3	16147992
Pubmed	The Hippo pathway regulates Wnt/beta-catenin signaling.	DVL1 DVL2	3.81e-04	13	78	2	20412773
Interaction	POLR1G interactions	WDR3 BPTF GTF2E1 BRPF1 ZMYND8 CDK11A DOT1L MGA TADA3 PCID2 DNMT3A NCBP3	2.76e-07	489	76	12	int:POLR1G
GeneFamily	PWWP domain containing	BRPF1 ZMYND8 DNMT3A	5.65e-05	22	62	3	1147
GeneFamily	Dishevelled segment polarity proteins\|PDZ domain containing	DVL1 DVL2	6.91e-05	4	62	2	505
ToppCell	Control-Myeloid-Neutrophils-Neutrophils\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CSF1R VNN2 CD300A SIGLEC5 IL1RAP	7.36e-06	153	78	5	e3630f2b10f33092a3b6a63dba3a39fbdecbc7bd
ToppCell	Control-Myeloid-Neutrophils\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CSF1R VNN2 CD300A SIGLEC5 IL1RAP	7.36e-06	153	78	5	c33d63b2d1a220bc428e776b157b23faa43ea8ca
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WDR91 TTC8 ARSB CSF1R CD300A	1.16e-05	168	78	5	c3d2d573f21350a4a674faff30b06ff644d00ac3
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDK5RAP2 ATAD2 MGA DNAI3 HPS3	1.19e-05	169	78	5	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERCC5 RELB BCAR1 DNAH8 SENP7	1.33e-05	173	78	5	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERCC5 RELB BCAR1 DNAH8 SENP7	1.33e-05	173	78	5	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	Transverse-T_cell-Tfh\|T_cell / Region, Cell class and subclass	PITPNM2 VNN2 SECISBP2 ARHGAP27 IL1RAP	2.61e-05	199	78	5	33ffea12b8228e0b5bd8942531c3b21d24224725
Disease	neurodegenerative disease (implicated_via_orthology)	DVL1P1 FIG4 DVL1 DVL2 NPLOC4	3.97e-05	145	77	5	DOID:1289 (implicated_via_orthology)
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	6.69e-05	5	77	2	DOID:11198 (is_implicated_in)
Disease	lung cancer (is_marker_for)	ERCC5 CSF1R DNMT3A	1.46e-04	39	77	3	DOID:1324 (is_marker_for)
Disease	atopic dermatitis (implicated_via_orthology)	TRAF3IP2 RELB	3.64e-04	11	77	2	DOID:3310 (implicated_via_orthology)
Disease	lipid metabolism disorder (implicated_via_orthology)	HSD17B4 FADS2B	6.90e-04	15	77	2	DOID:3146 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	BRPF1 ZMYND8	7.88e-04	16	77	2	DOID:0050888 (implicated_via_orthology)
Disease	nicotine dependence	DVL1P1 DVL1 CDH10	1.13e-03	78	77	3	EFO_0003768
Disease	level of Sterol ester (27:1/16:0) in blood serum	USP24 RELB	2.10e-03	26	77	2	OBA_2045191
Disease	selenium measurement	ARSB CMYA5	2.61e-03	29	77	2	EFO_0006331

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLKPPEDEAEHYKIP	TADA3	176	O75528
PAVLEIPSKEHPYDA	ATP6V1F	86	Q16864
GLEPPEEEKNPYKEV	DNMT3A	421	Q9Y6K1
DPLLEVYDVPPSVEK	BCAR1	281	P56945
KPVDPDEVPDYVTVI	ATAD2	1011	Q6PL18
EVPPDYDKHNPEQKQ	CCNY	156	Q8ND76
PYQDHDQPPVLKKER	DOT1L	1156	Q8TEK3
VDHPENEIPYPIKDV	LVRN	811	Q6Q4G3
PPEVPEEQEEYKEHI	DNAI3	131	Q8IWG1
VYHLECVKPPLEEVP	BPTF	411	Q12830
DEEETPYLVKIPVPA	DVL2	21	O14641
PNPEAPHVLDVYLEE	TP53BP2	851	Q13625
EVPLQPDKHDGDKYP	CDK5RAP2	1646	Q96SN8
FKTPPYEDLEIVEPV	RELB	361	Q01201
PEFEKPVYEVLVPES	PCDHB18P	186	Q96TA0
PPPQIYDKQLDEREH	MAPK10	371	P53779
PNPVIREEDKDPVYL	MGA	1216	Q8IWI9
HVVYEKEPGEELLIP	IL1RAP	251	Q9NPH3
DIPVQHYVPEFPEKE	LACTB	186	P83111
PPIDHSEIDYPPFEK	DDX42	201	Q86XP3
PPRSKYIHPDDELVL	POLD2	121	P49005
PHFEYIEQPIIEEKP	KIAA1586	106	Q9HCI6
EDMLSKLPPDYIPHE	DNAH8	4226	Q96JB1
PFDEDYLNHLEPPVK	NPLOC4	146	Q8TAT6
VEYHEELPALKQPRE	NCBP3	371	Q53F19
LELPQAAPPQIYHEK	JOSD1	16	Q15040
DPVPHNEYKTEEDPK	PITPNM2	146	Q9BZ72
PHLVIYIDVPVPEVQ	NDUFA10	201	O95299
DHLEEKIPALQYPPE	PLIN1	96	O60240
EQHVKPNIYPKDPDI	FADS2B	256	A8MWK0
QDDSYIEPEPVEPLK	OSBPL8	361	Q9BZF1
PEEKCQQVLEPPYDE	PCID2	46	Q5JVF3
DDPYPEVLSQEPFHK	CSF1R	451	P07333
IPLHVPDPKYRQDLV	DACT2	251	Q5SW24
EPVLHLDAPKDPYDL	GFY	451	I3L273
ERLKEHDLDPTAPPY	CDH10	716	Q9Y6N8
TPEVIKHLPLPYDEV	FIG4	636	Q92562
PEDLVEALKPEYVAP	HSD17B4	206	P51659
PPYATPEAQEEEIVH	CMYA5	906	Q8N3K9
VEKIYPQIPDHLKEP	SQLE	361	Q14534
LKHEYFRETPLPIDP	CDK11A	706	Q9UQ88
EKLHQLPYQPTPDEL	MAST4	311	O15021
VHEPLQVPEEYLKPY	ARSB	241	P15848
DEEETPYLVKLPVAP	DVL1	11	O14640
KEIVPYNEEDPVDPT	ENAM	646	Q9NRM1
DEEETPYLVKLPVAP	DVL1P1	11	P54792
DAFQKPVPLEQHPDY	ZMYND8	171	Q9ULU4
KLPAEIYQEPQPETE	SAMD15	46	Q9P1V8
EYILDPEPQPTREKQ	NOA1	76	Q8NC60
YEILEPEPTEIPALK	GTF2E1	201	P29083
DYTKPLEHPPVKRNE	TSEN2	131	Q8NCE0
KPSENYHQDPKLPEE	SENP7	341	Q9BQF6
YHQDPKLPEEITTKP	SENP7	346	Q9BQF6
VPEKEGYEPHIPDHL	UVSSA	411	Q2YD98
VDERLIYKPHPQDPE	PRELID3B	106	Q9Y3B1
PEAVIPYANHELKEE	HPS3	916	Q969F9
NDLYVLPPLQEEEKH	ERCC5	141	P28715
VYEVIQDLHVPPPEE	ARHGAP27	201	Q6ZUM4
LDDEILQLETPPKYH	SOCS4	251	Q8WXH5
PGDAPPLEEQKELHY	SIGLEC5	506	O15389
EDGPPALKEKEEPHY	SECISBP2	806	Q96T21
PVPLSEVPDYLDHIK	BRPF1	656	P55201
LQEKPAPPREVEVEY	CD300A	241	Q9UGN4
SQLLKPIPEYSPEEE	TRAF3IP2	26	O43734
QEKLSSEVEDPPPYL	CDK5RAP1	76	Q96SZ6
PEDPAVYKPLSQEEL	CNOT4	61	O95628
HLYSEPQFNVPEKPE	VNN2	181	O95498
HEQILPRVKPYDCPE	ZNF460	186	Q14592
YDQEPDPELPVHQAA	TTC8	36	Q8TAM2
QDTIPEYPELQLDPK	ZNF274	81	Q96GC6
ANYVEVLPADEIPKP	SORBS3	431	O60504
TPEPPAEHYQAILEE	TTLL12	271	Q14166
DPPPAYHEVVDAEKN	USP24	96	Q9UPU5
RLPPEYEKELHIALE	SLC30A5	651	Q8TAD4
AYLQEIEDPEEPDPK	WDR3	221	Q9UNX4
PEEEEALVQHKLPPY	WDR91	216	A4D1P6
ELFLNKESPHEPDPE	PPP1R10	496	Q96QC0
EAPLYVVDKPVPEES	PTK7	676	Q13308
PVAIINLKEYDPDDH	TYW1B	61	Q6NUM6