Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	LRP2 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3	1.20e-04	749	41	8	GO:0005509
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP2 LRP6	4.85e-04	16	41	2	GO:0005041
GeneOntologyMolecularFunction	nuclear receptor binding	LRP2 PRAMEF7 PRAMEF8 NR0B1	5.75e-04	187	41	4	GO:0016922
GeneOntologyMolecularFunction	kinase inhibitor activity	LRP6 SMO SPRED2	7.31e-04	86	41	3	GO:0019210
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP2 LRP6	8.43e-04	21	41	2	GO:0030228
GeneOntologyBiologicalProcess	negative regulation of developmental process	LRP6 PRAMEF7 SPRY3 HSPG2 SMO LTBP3 SPRED2 IL17D PRAMEF8 FAT3 NOTCH3	1.07e-05	1220	39	11	GO:0051093
GeneOntologyBiologicalProcess	brain development	LRP2 LRP6 HSPG2 SMO CELSR2 AMIGO3 NANOS1 NOTCH3 NR0B1	2.48e-05	859	39	9	GO:0007420
GeneOntologyBiologicalProcess	head development	LRP2 LRP6 HSPG2 SMO CELSR2 AMIGO3 NANOS1 NOTCH3 NR0B1	4.22e-05	919	39	9	GO:0060322
GeneOntologyBiologicalProcess	cell morphogenesis	LRP2 LRP6 SPRY3 HSPG2 SMO CELSR2 DMRT1 FAT3 NTN3 NOTCH3	5.53e-05	1194	39	10	GO:0000902
GeneOntologyBiologicalProcess	central nervous system development	LRP2 LRP6 HSPG2 SMO CELSR2 AMIGO3 SLC45A3 NANOS1 NOTCH3 NR0B1	5.65e-05	1197	39	10	GO:0007417
GeneOntologyBiologicalProcess	neuron development	LRP2 LRP6 SPRY3 HSPG2 SMO CELSR2 AMIGO3 NANOS1 FAT3 NTN3 NOTCH3	5.78e-05	1463	39	11	GO:0048666
GeneOntologyBiologicalProcess	regulation of ERK1 and ERK2 cascade	PRAMEF7 SPRY3 SPRED2 PRAMEF8 P2RY6 NLRP6	7.88e-05	385	39	6	GO:0070372
GeneOntologyBiologicalProcess	neuron projection development	LRP2 LRP6 SPRY3 HSPG2 SMO CELSR2 AMIGO3 FAT3 NTN3 NOTCH3	1.02e-04	1285	39	10	GO:0031175
GeneOntologyBiologicalProcess	ERK1 and ERK2 cascade	PRAMEF7 SPRY3 SPRED2 PRAMEF8 P2RY6 NLRP6	1.24e-04	418	39	6	GO:0070371
GeneOntologyBiologicalProcess	axon guidance	LRP2 HSPG2 SMO NTN3 NOTCH3	1.91e-04	285	39	5	GO:0007411
GeneOntologyBiologicalProcess	neuron projection guidance	LRP2 HSPG2 SMO NTN3 NOTCH3	1.94e-04	286	39	5	GO:0097485
GeneOntologyBiologicalProcess	negative regulation of cell differentiation	LRP6 PRAMEF7 SMO LTBP3 SPRED2 IL17D PRAMEF8 NOTCH3	1.94e-04	875	39	8	GO:0045596
GeneOntologyBiologicalProcess	oogenesis	PRAMEF7 PRAMEF8 DMRT1 NANOS1	2.11e-04	156	39	4	GO:0048477
GeneOntologyBiologicalProcess	positive regulation of cell population proliferation	LRP2 LRP6 PRAMEF7 HSPG2 SMO LTBP3 PRAMEF8 P2RY6 NOTCH3	3.02e-04	1190	39	9	GO:0008284
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	LRP2 LRP6 PRAMEF7 HSPG2 SMO PRAMEF8 FAT3 NTN3 NOTCH3 NR0B1	3.31e-04	1483	39	10	GO:0048646
GeneOntologyBiologicalProcess	thalamus development	LRP6 SMO	4.11e-04	16	39	2	GO:0021794
GeneOntologyBiologicalProcess	male sex determination	DMRT1 NR0B1	4.11e-04	16	39	2	GO:0030238
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	LRP2 HSPG2 SMO CELSR2 FAT3 NTN3 NOTCH3	4.48e-04	748	39	7	GO:0048667
GeneOntologyBiologicalProcess	cardiac septum morphogenesis	LRP2 LRP6 SMO	6.34e-04	89	39	3	GO:0060411
GeneOntologyBiologicalProcess	diencephalon development	LRP6 SMO NR0B1	6.55e-04	90	39	3	GO:0021536
GeneOntologyBiologicalProcess	retina morphogenesis in camera-type eye	LRP6 FAT3 IMPG2	6.55e-04	90	39	3	GO:0060042
GeneOntologyBiologicalProcess	neuron projection morphogenesis	LRP2 SPRY3 HSPG2 SMO CELSR2 NTN3 NOTCH3	6.78e-04	802	39	7	GO:0048812
GeneOntologyBiologicalProcess	cellular response to cholesterol	LRP6 SMO	7.15e-04	21	39	2	GO:0071397
GeneOntologyBiologicalProcess	negative regulation of ERK1 and ERK2 cascade	SPRY3 SPRED2 NLRP6	7.67e-04	95	39	3	GO:0070373
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	LRP2 SPRY3 HSPG2 SMO CELSR2 NTN3 NOTCH3	7.68e-04	819	39	7	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	LRP2 SPRY3 HSPG2 SMO CELSR2 NTN3 NOTCH3	8.07e-04	826	39	7	GO:0048858
GeneOntologyBiologicalProcess	female gamete generation	PRAMEF7 PRAMEF8 DMRT1 NANOS1	8.13e-04	223	39	4	GO:0007292
GeneOntologyBiologicalProcess	oocyte development	PRAMEF7 PRAMEF8 DMRT1	8.65e-04	99	39	3	GO:0048599
GeneOntologyBiologicalProcess	oocyte differentiation	PRAMEF7 PRAMEF8 DMRT1	9.70e-04	103	39	3	GO:0009994
GeneOntologyCellularComponent	extracellular matrix	SNED1 HSPG2 LTBP3 MEGF6 LRRC24 NTN3 IMPG2	2.20e-04	656	40	7	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	SNED1 HSPG2 LTBP3 MEGF6 LRRC24 NTN3 IMPG2	2.24e-04	658	40	7	GO:0030312
GeneOntologyCellularComponent	acrosomal vesicle	SPACA6 PRAMEF7 PRAMEF8 TMEM190	6.34e-04	206	40	4	GO:0001669
MousePheno	increased Sertoli cell proliferation	DMRT1 NR0B1	1.52e-05	3	32	2	MP:0031407
MousePheno	abnormal Sertoli cell proliferation	DMRT1 NR0B1	1.52e-05	3	32	2	MP:0031405
MousePheno	abnormal testis development	LRP2 DMRT1 NR0B1	6.21e-05	34	32	3	MP:0003830
Domain	EGF_1	LRP2 LRP6 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NTN3 NOTCH3 IMPG2	5.45e-12	255	41	11	PS00022
Domain	EGF-like_CS	LRP2 LRP6 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NTN3 NOTCH3 IMPG2	7.01e-12	261	41	11	IPR013032
Domain	EGF_2	LRP2 LRP6 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NTN3 NOTCH3 IMPG2	8.27e-12	265	41	11	PS01186
Domain	EGF_3	LRP2 LRP6 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3 IMPG2	6.54e-11	235	41	10	PS50026
Domain	EGF-like_dom	LRP2 LRP6 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3 IMPG2	1.16e-10	249	41	10	IPR000742
Domain	EGF_CA	LRP2 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3	2.10e-10	122	41	8	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3	2.39e-10	124	41	8	IPR001881
Domain	EGF	LRP2 LRP6 SNED1 HSPG2 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3	1.67e-09	235	41	9	SM00181
Domain	ASX_HYDROXYL	LRP2 SNED1 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3	1.97e-09	100	41	7	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 SNED1 LTBP3 CELSR2 MEGF6 FAT3 NOTCH3	2.98e-09	106	41	7	IPR000152
Domain	hEGF	SNED1 LTBP3 CELSR2 MEGF6 NOTCH3	3.75e-09	28	41	5	PF12661
Domain	EGF	LRP2 LRP6 SNED1 HSPG2 CELSR2 MEGF6 NOTCH3	9.99e-09	126	41	7	PF00008
Domain	Growth_fac_rcpt_	LRP2 HSPG2 LTBP3 CELSR2 MEGF6 NTN3 NOTCH3	4.39e-08	156	41	7	IPR009030
Domain	EGF_Ca-bd_CS	LRP2 SNED1 LTBP3 MEGF6 FAT3 NOTCH3	6.52e-08	97	41	6	IPR018097
Domain	EGF_CA	LRP2 SNED1 LTBP3 MEGF6 FAT3 NOTCH3	7.36e-08	99	41	6	PS01187
Domain	Laminin_EGF	HSPG2 CELSR2 MEGF6 NTN3	9.96e-07	35	41	4	PF00053
Domain	EGF_Lam	HSPG2 CELSR2 MEGF6 NTN3	9.96e-07	35	41	4	SM00180
Domain	EGF_CA	LRP2 LTBP3 MEGF6 FAT3 NOTCH3	1.21e-06	86	41	5	PF07645
Domain	Laminin_EGF	HSPG2 CELSR2 MEGF6 NTN3	1.40e-06	38	41	4	IPR002049
Domain	EGF_LAM_2	HSPG2 CELSR2 NTN3	3.83e-05	30	41	3	PS50027
Domain	EGF_LAM_1	HSPG2 CELSR2 NTN3	3.83e-05	30	41	3	PS01248
Domain	LAM_G_DOMAIN	HSPG2 CELSR2 FAT3	7.85e-05	38	41	3	PS50025
Domain	Laminin_G_2	HSPG2 CELSR2 FAT3	9.17e-05	40	41	3	PF02210
Domain	LDLR_class-A_CS	LRP2 LRP6 HSPG2	9.17e-05	40	41	3	IPR023415
Domain	SPR	SPRY3 SPRED2	9.81e-05	7	41	2	PS51227
Domain	Sprouty	SPRY3 SPRED2	9.81e-05	7	41	2	IPR007875
Domain	Sprouty	SPRY3 SPRED2	9.81e-05	7	41	2	PF05210
Domain	LamG	HSPG2 CELSR2 FAT3	1.22e-04	44	41	3	SM00282
Domain	Ldl_recept_a	LRP2 LRP6 HSPG2	1.31e-04	45	41	3	PF00057
Domain	-	LRP2 LRP6 HSPG2	1.40e-04	46	41	3	4.10.400.10
Domain	LDLRA_1	LRP2 LRP6 HSPG2	1.59e-04	48	41	3	PS01209
Domain	LDrepeatLR_classA_rpt	LRP2 LRP6 HSPG2	1.69e-04	49	41	3	IPR002172
Domain	LDLa	LRP2 LRP6 HSPG2	1.69e-04	49	41	3	SM00192
Domain	LDLRA_2	LRP2 LRP6 HSPG2	1.69e-04	49	41	3	PS50068
Domain	Laminin_G	HSPG2 CELSR2 FAT3	2.79e-04	58	41	3	IPR001791
Domain	EGF_extracell	LRP2 MEGF6 NOTCH3	3.08e-04	60	41	3	IPR013111
Domain	EGF_2	LRP2 MEGF6 NOTCH3	3.08e-04	60	41	3	PF07974
Domain	SEA	HSPG2 IMPG2	4.21e-04	14	41	2	SM00200
Domain	Ldl_recept_b	LRP2 LRP6	4.21e-04	14	41	2	PF00058
Domain	LDLRB	LRP2 LRP6	4.21e-04	14	41	2	PS51120
Domain	LY	LRP2 LRP6	4.85e-04	15	41	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LRP6	4.85e-04	15	41	2	IPR000033
Domain	-	PRAMEF7 PRAMEF8 AMIGO3 LRRC24 NLRP6	6.56e-04	321	41	5	3.80.10.10
Domain	L_dom-like	PRAMEF7 PRAMEF8 AMIGO3 LRRC24 NLRP6	7.23e-04	328	41	5	IPR032675
Domain	PRAME_family	PRAMEF7 PRAMEF8	7.85e-04	19	41	2	IPR026271
Domain	SEA	HSPG2 IMPG2	1.06e-03	22	41	2	PF01390
Domain	SEA	HSPG2 IMPG2	1.16e-03	23	41	2	PS50024
Domain	SEA_dom	HSPG2 IMPG2	1.16e-03	23	41	2	IPR000082
Domain	-	HSPG2 CELSR2 FAT3	1.18e-03	95	41	3	2.60.120.200
Domain	ConA-like_dom	HSPG2 CELSR2 FAT3 TRIM10	1.33e-03	219	41	4	IPR013320
Domain	cEGF	LRP2 LTBP3	1.48e-03	26	41	2	IPR026823
Domain	cEGF	LRP2 LTBP3	1.48e-03	26	41	2	PF12662
Domain	-	LRP2 LRP6	3.31e-03	39	41	2	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	LRP2 LRP6	4.58e-03	46	41	2	IPR011042
Domain	GPCR_2-like	SMO CELSR2	7.68e-03	60	41	2	IPR017981
Domain	GPCR_2_secretin-like	SMO CELSR2	7.68e-03	60	41	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	SMO CELSR2	7.93e-03	61	41	2	PS50261
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	LRP6 PRAMEF7 SMO PRAMEF8 NOTCH3 NR0B1	1.32e-05	424	43	6	21731673
Pubmed	Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.	CELSR2 MEGF6	5.35e-05	9	43	2	9693030
Pubmed	Nonsyndromic Disorders of Testicular Development Overview	DMRT1 NR0B1	6.68e-05	10	43	2	20301714
Pubmed	Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes.	NOTCH3 NR0B1	6.68e-05	10	43	2	10198174
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP2 LRP6	8.15e-05	11	43	2	24639464
Pubmed	Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.	HSPG2 NTN3	8.15e-05	11	43	2	15186747
Pubmed	A forward genetic screen in mice identifies mutants with abnormal cortical patterning.	LRP2 LRP6	8.15e-05	11	43	2	23968836
Pubmed	Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.	SPRY3 SPRED2	9.78e-05	12	43	2	17974561
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP2 LRP6	1.35e-04	14	43	2	17389516
Pubmed	LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.	LRP2 SMO	1.55e-04	15	43	2	22340494
Pubmed	Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome.	LRP2 SMO	1.77e-04	16	43	2	15005800
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF8	2.01e-04	17	43	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF8	2.01e-04	17	43	2	37781892
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF8	2.26e-04	18	43	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF8	2.26e-04	18	43	2	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF8	2.26e-04	18	43	2	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF8	2.26e-04	18	43	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF8	2.26e-04	18	43	2	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF8	2.52e-04	19	43	2	28604677
Pubmed	The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification.	LRP6 NOTCH3 NR0B1	2.62e-04	100	43	3	24859004
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP2 NOTCH3 IMPG2	2.70e-04	101	43	3	23382219
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF8	2.80e-04	20	43	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF8	2.80e-04	20	43	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF8	2.80e-04	20	43	2	21425410
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP2 LRP6	3.09e-04	21	43	2	21337463
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF8	3.40e-04	22	43	2	31729367
Pubmed	Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.	SPRY3 SPRED2	3.72e-04	23	43	2	20934536
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	HSPG2 SMO	3.72e-04	23	43	2	30814516
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF8	3.72e-04	23	43	2	19480014
Pubmed	Primary cilia in murine palatal rugae development.	SMO CELSR2	3.72e-04	23	43	2	31226309
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 LTBP3 SPRED2 CELSR2 MEGF6 LRRC24 SLC45A3	3.80e-04	1105	43	7	35748872
Pubmed	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	HS3ST6 HSPG2	4.05e-04	24	43	2	34653670
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	HSPG2 LTBP3 MEGF6	4.26e-04	118	43	3	21078624
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF8	4.40e-04	25	43	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF8	4.40e-04	25	43	2	12620990
Pubmed	LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli.	LRP2 SMO	4.76e-04	26	43	2	26439398
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF8	4.76e-04	26	43	2	18500982
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	LRP6 CELSR2	4.76e-04	26	43	2	37228654
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF8	5.53e-04	28	43	2	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF8	6.35e-04	30	43	2	38786026
Pubmed	Functional analysis of secreted and transmembrane proteins critical to mouse development.	LRP6 NOTCH3	6.79e-04	31	43	2	11431694
Pubmed	ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.	HSPG2 NOTCH3	6.79e-04	31	43	2	22274697
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF7 PRAMEF8	7.23e-04	32	43	2	37889087
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	AMIGO3 LRRC24	8.17e-04	34	43	2	18848646
Pubmed	The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.	DMRT1 NR0B1	8.17e-04	34	43	2	20007774
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF7 PRAMEF8	8.66e-04	35	43	2	19389355
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	LRP2 CELSR2	8.66e-04	35	43	2	30940800
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	LRP2 HSPG2 ZBTB32 MEGF6 NR0B1	8.93e-04	608	43	5	16713569
Pubmed	Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.	SMO NOTCH3	9.67e-04	37	43	2	26697723
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF7 HSPG2 SMO PRAMEF8	1.04e-03	363	43	4	14691545
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	ZBTB32 PRAMEF8	1.13e-03	40	43	2	25011449
Cytoband	8q24.3	LYPD2 WDR97 LRRC24	1.67e-04	113	43	3	8q24.3
Cytoband	1p36.21	PRAMEF7 PRAMEF8	1.61e-03	63	43	2	1p36.21
Cytoband	2q37.3	SNED1 ANKMY1	2.40e-03	77	43	2	2q37.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	PRAMEF7 HSPG2 PRAMEF8 MEGF6	3.75e-03	681	43	4	chr1p36
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	LYPD2 WDR97 LRRC24	4.50e-03	355	43	3	chr8q24
GeneFamily	Low density lipoprotein receptors	LRP2 LRP6	2.34e-04	13	32	2	634
GeneFamily	PRAME family	PRAMEF7 PRAMEF8	8.17e-04	24	32	2	686
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ANKMY1 FAT3 NR0B1	1.51e-05	155	43	4	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	cellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HS3ST6 NANOS1 FAT3 RUFY4	1.71e-05	160	43	4	9049707a4487f2337a17976ceb5fbd8815ab9e1d
ToppCell	cellseq2-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HS3ST6 NANOS1 FAT3 RUFY4	1.71e-05	160	43	4	f2cfec54cf48a655f473b830be7d141c54b521ff
ToppCell	cellseq2-Epithelial-Epithelial_Neuro-Secretory\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HS3ST6 NANOS1 FAT3 RUFY4	1.71e-05	160	43	4	0eb50b3c494e1b65d40104b3b5411b57bb72b959
ToppCell	3'_v3-blood-Lymphocytic_B-ABC_aged-B_memory\|blood / Manually curated celltypes from each tissue	ZBTB32 WDR97 NANOS1 IMPG2	2.07e-05	168	43	4	2ce1a30feb2704a9516d1dab161a26cb0555abb5
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	LYPD2 HSPG2 LTBP3 CALHM4	2.48e-05	176	43	4	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LYPD2 SPRY3 SMO P2RY6	2.53e-05	177	43	4	709235694cc711b9b79690e23c94577b2ae06811
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LYPD2 SPRY3 SMO P2RY6	2.53e-05	177	43	4	7f9c2a45a994b32f15e5693f7cb873716a4eb568
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LYPD2 HSPG2 LTBP3 CALHM4	2.65e-05	179	43	4	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-G_(Club-Clara_cells)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	HS3ST6 LYPD2 SPRY3 NOTCH3	3.48e-05	192	43	4	c7c232545fad8ad327ab94bd0def8dc5daacd03d
Disease	aortic stenosis	SPRED2 CELSR2 NLRP6	7.96e-06	31	37	3	EFO_0000266
Disease	Hypodontia	LRP6 LTBP3	1.38e-04	14	37	2	C0020608
Disease	Osteoarthritis of hip	SMO LTBP3	2.87e-04	20	37	2	C0029410
Disease	Craniofacial Abnormalities	LRP2 HSPG2 LTBP3	9.87e-04	156	37	3	C0376634
Disease	Stevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine	LTBP3 IL17D	9.91e-04	37	37	2	EFO_0004276, EFO_0004775, EFO_0006997

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLRCCGPPFCLKEAY	ABCA13	4051	Q86UQ4
LCYSRPCGPHGRCRS	CELSR2	1291	Q9HCU4
YLFAPPCRCCRRACR	AMIGO3	401	Q86WK7
CRPCPCPYIDASRRF	HSPG2	811	P98160
LCQRCGLPAPEYRAG	FER1L4	1376	A9Z1Z3
CPVLRRYTCPLCGAS	NANOS1	241	Q8WY41
RFLCSCPPGYQGRSC	NOTCH3	141	Q9UM47
LPLRAAGCPAACRCY	LRRC24	16	Q50LG9
HLCLYRPQGLRCACP	LRP6	601	O75581
PRYLPEAYCLCRGCL	IL17D	106	Q8TAD2
LCLLRPGGYSCACPQ	LRP2	4341	P98164
CGELAPALRCYVCPE	LYPD2	16	Q6UXB3
PGGRPVALLYRCCFC	NR0B1	121	P51843
DAACGCPRLLPGRRY	NTN3	511	O00634
LGCVLYPDACKRSPC	FAT3	4016	Q8TDW7
YCCSCAPPYRRISPL	CALHM4	81	Q5JW98
LLPCPRCYGILTCSK	ANKMY1	891	Q9P2S6
RCVNLPGSYRCECRP	LTBP3	1096	Q9NS15
FCTVPCPRCGIRASY	PRAMEF8	451	Q5VWM4
GCYSRVCDLPLDCPV	SPACA6	141	W5XKT8
YCVRCCPAGQALRLI	NLRP6	661	P59044
PRLPKCARCRNHGYA	DMRT1	71	Q9Y5R6
AYCLCALPGRCPPAA	HS3ST6	41	Q96QI5
PLCIPRCRAAFPQCY	PRR23D1	201	E9PI22
CYCLLACRLCRQDGP	P2RY6	211	Q15077
RGRCHRLYGACLCDP	MEGF6	616	O75095
FSRRYPCRLCGGLLC	RUFY4	531	Q6ZNE9
CRCFPGYLSVEERPC	IMPG2	1036	Q9BZV3
YCCSCLRLRPLSDGP	PNPT1	6	Q8TCS8
PLCIPRCRAAFPQCY	PRR23D2	201	P0DMB1
FLPCLCCYLPTRGCL	SPRY3	231	O43610
CCPCRARLAFRNLGA	SLC45A3	241	Q96JT2
CRNLPGAYVCRCPAG	SNED1	806	Q8TER0
PPLCRAFACRGCQLA	COA8	26	Q96IL0
FCTVPCPRCGIRASY	PRAMEF7	451	Q5VXH5
SPNLCLRLRCCYRNG	TMEM190	51	Q8WZ59
CCYPAVALCALGRRV	WDR97	641	A6NE52
GCPCNYRAPSCKVTR	SPATA31D1	1456	Q6ZQQ2
FLAPCMCCYLPLRAC	SPRED2	386	Q7Z698
RAAPCEPLRYNVCLG	SMO	66	Q99835
PPYLACRLLAAACIC	SLC7A6	161	Q92536
CRACLTRYCEIPGPD	TRIM10	36	Q9UDY6
APYRCSLCGAGCPSL	ZBTB32	426	Q9Y2Y4